Seminal transforming growth factor-beta in normal and infertile men. (1/241)
Transforming growth factor-beta (TGFbeta) is a cytokine with autocrine and paracrine action in the testis and potent immunoregulatory and anti-inflammatory activities. In the present study, we examined the concentration of latent (acid-activatable) and free (active) TGFbeta in seminal plasma from normal subjects (n = 23) and infertile (n = 40) patients, by using a TGFbeta specific immunoenzymological assay, and a bioassay (CCL64 cell line growth inhibition) detecting any form of TGFbeta. Free TGFbeta1 was present in normal subjects at a concentration (1.82 +/- 1.06 ng/ml) close to that known to give maximal stimulation in vitro. In pathological groups, the mean concentrations were not significantly different from the normal ones. Latent TGFbeta1 was present in normal seminal plasma at a high concentration (92.4 +/- 29.2 ng/ml). In subjects with pathologies of both testis and genital apparatus, or with epididymal occlusion, mean latent TGFbeta1 concentrations were normal, whereas transferrin concentrations were lower. The concentrations found in the epididymal occlusion group indicate that TGFbeta1 is, for a large part, secreted by the genital tract. In the testicular pathology group, TGFbeta1 concentrations were 130.7 +/- 61.2 ng/ml, a mean not statistically different from normal, although higher. No differences were found between patients with high and normal blood plasma follicle stimulating hormone, and this is consistent with the notion that most TGFbeta1 in seminal plasma is not of testicular origin. The TGFbeta bioassay ensured that immunologically detected TGFbeta was present in a bioactive or bioactivatable form. Furthermore, the values found in normal and pathological seminal plasmas were usually higher than those detected by the immunoassay, suggesting that other forms of TGFbeta might be present. Together, the present data show that very large amounts of TGFbeta are present in human seminal plasma. The TGFbeta ligand assay in the seminal plasma appears to indicate no differences between normal and infertile subjects. (+info)Absence of testicular DAZ gene expression in idiopathic severe testiculopathies. (2/241)
Deletions of the DAZ (deleted in azoospermia) gene family are frequently responsible for male infertility and are generally assessed by analyses of genomic DNA extracted from peripheral leukocytes. The multicopy nature of this gene prevents the distinction of intragenic deletions or deletions not involving the whole DAZ gene cluster. Thus it is still unclear whether each DAZ copy is effectively expressed in the testis. We analysed, by reverse transcription-polymerase chain reaction (RT-PCR), the expression of DAZ, RBM and SRY genes, in testicular cells from infertile men affected by idiopathic severe hypospermatogenesis, obstructive azoospermia and Sertoli cell-only syndrome. Normal mRNA for DAZ, RBM and SRY were observed in obstructive azoospermia, whereas only SRY transcripts were detected when only Sertoli cells were present. Nine out of 10 patients affected by idiopathic severe hypospermatogenesis had normal expression of SRY, RBM and DAZ, while in one patient no DAZ transcript was detected, suggesting that his testiculopathy was related to the absence of DAZ expression. The lack of DAZ mRNA in testicular cells with an apparently normal DAZ gene constitution on DNA extracted from leukocytes may be explained by different hypotheses: (i) not all the copies of the DAZ gene cluster are transcribed in the germ cells and the reported patient had a small deletion involving only the active ones; (ii) the patient may be mosaic for the DAZ gene having a normal constitution in leukocytes and be deleted for DAZ gene in the testis; (iii) abnormalities of DAZ transcription may exist. These findings highlight the intrinsic interpretative difficulties of normal PCR analysis for DAZ and RBM on leukocytes and suggest caution in the use of germ cells for assisted reproductive techniques in these cases to avoid transmission of genetic abnormalities to male offspring. (+info)Testicular adrenal rests: evidence for luteinizing hormone receptors and for distinct types of testicular nodules differing for their autonomization. (3/241)
We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonadotropin (hCG) and later on with orchidopexy. He was treated with oral dexamethasone (0.625 mg per day) for the following 13 years. After one year, there was a marked reduction in steroid hormone levels (17-hydroxyprogesterone (17-OH P) from 27.2 to 1.2 nmol/l, testosterone from >104 to 4.8 nmol/l, estradiol (E(2)) from 481 to 33 pmol/l). After the same period of time, both testicular volume and nodularity decreased: from 45 to 18 ml and from numerous to four nodules in the right testis, and from 40 to 13 ml and from numerous to three nodules in the left testis. At the third year, there were transient increases in serum gonadotropins, testicular volume (right testis = 25 ml, left testis = 20 ml) and steroid hormones, including cortisol (serum ACTH and dehydroepiandrosterone sulfate remained suppressed). At the fourth year of follow-up, there were still four nodules in the right testis and three in the left testis. The LH-dependency (which implies possession of LH/hCG receptors) of these nodules was also substantiated by their steroidogenic response to an acute i.m. hCG test. An exogenous ACTH stimulation test increased serum 17-OH P and cortisol. Since these nodules, unlike the majority of those present initially, were not suppressed by the corticosteroid therapy and since they were not detected when the patient returned for control at 23 years of age, they had partial autonomy from ACTH. At 23 years of age, the patient had a single nodule in the right testis (right testis volume = 13 ml, left testis volume = 10 ml), which should have accounted for the consistent difference in size between the two gonads. Serum LH was about 7 mU/l and FSH about 23 mU/l. The responsiveness of plasma steroid hormones to hCG had changed quantitatively and qualitatively. Secretion of cortisol was absent, secretion of 17-OH P and testosterone was reduced, and secretion of E(2) was much increased. The ACTH stimulation test showed that serum cortisol did not respond, while the other steroids responded in the order of 17-OH P>E(2)> testosterone. We conclude that there were three different groups of TAR when the patient was already 10 years old: (i) ACTH-sensitive (the majority), (ii) partially ACTH-insensitive but LH/hCG-sensitive (three nodules in the left testis and three in the right testis), (iii) almost entirely ACTH-insensitive and partially hCG-insensitive (a single nodule in the right testis). Probably, the never suppressed gonadotropin levels (presumably due to the bilateral testicular damage subsequent to the cryptorchid state) and the hCG therapy were major etiological factors for the appearance of the second and third population of TAR. (+info)Unusual sonographic appearance of an epidermoid cyst of the testis. (4/241)
Epidermoid cyst of the testis is a rare benign testicular tumor with varied sonographic appearances. We present a case in which two specific ultrasonographic patterns were seen: (1) an "onion ring" configuration of alternating hyperechoic and hypoechoic regions, described previously as being characteristic of this lesion, and (2) a heterogeneous region with multiple punctate hyperechoic foci. (+info)Specific expression of heat shock protein HspA2 in human male germ cells. (5/241)
In the mouse, the heat shock protein 70-2 (Hsp70-2) has been found to play a critical role in spermatogenesis. The HspA2 gene is the human homologue of the murine Hsp70-2 gene with 91.7% identity in the nucleotide coding sequence. We examined the expression of HspA2 in human tissues. To detect HspA2 expression, antiserum 2A that was raised against mouse Hsp70-2 and that cross-reacted with human HspA2 protein expressed in Escherichia coli was used. The results of Western blotting indicate that significant HspA2 expression occurs in testes with normal spermatogenesis, whereas only a low amount of HspA2 was expressed in testis with Sertoli cell-only syndrome. Only a small amount of HspA2 was detected in breast, stomach, prostate, colon, liver, ovary, and epididymis. Immunoreactivity to HspA2 was present in spermatocytes and spermatids in the testes with normal spermatogenesis, while immunoreactivity to HspA2 in testis with Sertoli cell-only syndrome was remarkably decreased or inconspicuous over the entire cell. These results demonstrate that the HspA2 protein is highly expressed in human male specific germ cells, suggesting that HspA2 protein may play a specific role during meiosis in human testes as found in the murine model. (+info)Highly sensitive quantitative telomerase assay of diagnostic testicular biopsy material predicts the presence of haploid spermatogenic cells in therapeutic testicular biopsy in men with Sertoli cell-only syndrome. (6/241)
The role of a telomerase assay in the recognition of Sertoli cell-only syndrome with testicular foci of haploid cells was evaluated. Men with Sertoli cell-only syndrome (n = 23) were given a new diagnostic testicular biopsy. Part of the biopsy was stained and the remainder was processed for the quantitative telomerase assay. After 3-13 months, a therapeutic testicular biopsy was performed. This material was minced and then examined using confocal laser scanning microscopy and fluorescent in-situ hybridization. Histology of diagnostic testicular biopsy material confirmed the diagnosis of Sertoli cell-only syndrome in all the participants. All seven men with a telomerase assay value in their diagnostic testicular biopsy of >42 total product generated (TPG) U/microg protein had haploid cells (i.e. spermatozoa and/or spermatids) in their therapeutic testicular biopsy. Among participants with telomerase assay values <42 TPG U/microg protein, only one man had haploid cells in his therapeutic testicular biopsy. Thus, telomerase assay values >42 TPG U/microg protein in the diagnostic biopsy identified 87.5% of the Sertoli cell-only syndrome men with haploid cells in their therapeutic testicular biopsy. Significantly higher values of the telomerase assay were found in men with testicular foci of haploid cells than in men without these foci. The use of a quantitative telomerase assay biopsy appears to be important for identifying those men with Sertoli cell-only syndrome who have foci of haploid cells and can be candidates for assisted reproduction techniques. (+info)Ultrasonography of intratesticular lesions: its role in clinical management. (7/241)
Ultrasound is the primary imaging modality in the investigation of patients with symptoms related to the scrotum, and is pivotal to the diagnosis of suspected testicular malignancy. This retrospective study analysed the results of testicular ultrasound at a large teaching hospital over a five year period. We wished to examine the clinical consequences for patients in whom ultrasound findings were suspicious of testicular cancer, and the accuracy of the ultrasound diagnosis. Real time ultrasound examinations were performed, providing multiplanar imaging of the testis and para testicular tissues. Over a five year period 661 examinations were carried out. An intratesticular lesion was identified in 44 patients; nineteen of these patients were shown to have testicular malignancy following tissue diagnosis. When ultrasound was used to identify testicular malignancy in those patients with an intratesticular lesion, it had a sensitivity of 94.7% and a specificity of 59.1%. A tissue diagnosis was obtained in 93% of those patients thought likely to have a testicular malignancy on sonographic assessment, and in 40% of those in whom a diagnosis of malignancy was possible, but less likely. Our study shows that this modality can be used to aid the clinician in deciding which patients should undergo orchidectomy, invasive biopsy or clinical surveillance. (+info)Halicephalobus gingivalis (H. deletrix) infection in two horses in southern California. (8/241)
Two horses, a 16-year-old male Holsteiner and a 5-year-old male miniature horse, were diagnosed with halicephalobiasis at the California Veterinary Diagnostic Laboratory System, San Bernardino Branch, in April and June of 1998. Over a period of 4 weeks, the Holsteiner horse developed renal dysfunction, blepharospasm, and blindness in the right eye. A 15-cm-diameter mass was detected on ultrasound examination in the right kidney. Terminally, the animal developed seizures and was euthanized. The miniature horse had a 6-week-long illness characterized by testicular enlargement and uveitis. This animal developed ataxia and died. Necropsy examination revealed bilateral enlargement of the kidneys in both horses, petechial hemorrhages of the optic nerve (Holsteiner), and a diffusely firm and enlarged left testicle (miniature horse). Microscopic evaluation of tissues revealed granulomatous nephritis, optic neuritis, retinitis, and encephalitis in both horses and orchitis in only the miniature horse with intralesional rhabditiform nematodes. Halicephalobus gingivalis was found in the urine sediment of both animals and in semen of the Holsteiner horse. (+info)Testicular diseases refer to a range of medical conditions that affect the testes, including inflammation, infection, tumors, trauma, and congenital abnormalities, which can impact fertility, hormone production, and overall reproductive health.
Testicular diseases refer to a range of conditions that affect the testicles, the male reproductive organs located in the scrotum. These diseases can affect either one or both testicles and may cause pain, swelling, or impact fertility. Here are some examples of testicular diseases:
1. Testicular cancer: A malignant tumor that develops in the testicle. It is a relatively rare cancer but is highly treatable if detected early.
2. Testicular torsion: A surgical emergency that occurs when the spermatic cord, which supplies blood to the testicle, becomes twisted, cutting off the blood flow.
3. Epididymitis: An infection or inflammation of the epididymis, a coiled tube that stores and carries sperm from the testicle.
4. Orchitis: An infection or inflammation of the testicle itself. It can occur on its own or as a complication of mumps.
5. Hydrocele: A fluid-filled sac that forms around the testicle, causing swelling.
6. Varicocele: Enlarged veins in the scrotum that can cause pain and affect fertility.
7. Inguinal hernia: A condition where a portion of the intestine or fat protrudes through a weakened area in the abdominal wall, often appearing as a bulge in the groin or scrotum.
8. Testicular trauma: Injury to the testicle, which can result from accidents, sports injuries, or other causes.
9. Undescended testicles: A condition where one or both testicles fail to descend from the abdomen into the scrotum before birth.
It is essential for men to perform regular self-examinations to check for any unusual lumps, swelling, or pain in the testicles and seek medical attention if they notice any changes.
Testicular Cancer | GreenMedInfo | Disease | Natural Medicine
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Dirofilaria repens Testicular Infection in Child, Italy. Emerging Infectious Diseases. 2022;28(12):2569-2572. doi:10.3201/ ... Our case highlights that testicular dirofilariasis might mimic a testicular tumor and lead to unnecessary orchiectomy because ... Testicular Dirofilaria repens infection was identified and confirmed by sequence analysis in a child in northeastern Italy. ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
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Testicular cancer mainly affects young men between the ages of 20 and 39. You can get cancer in one or both testicles. Know ... ClinicalTrials.gov: Genital Diseases, Male (National Institutes of Health) * ClinicalTrials.gov: Testicular Diseases (National ... Testicular Injuries (Nemours Foundation) Also in Spanish * Testicular Torsion (For Parents) (Nemours Foundation) Also in ... Testicular torsion repair - series (Medical Encyclopedia) Also in Spanish * Varicocele Embolization (American College of ...
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Testicular cancer causes autoimmune disease, for them scientists resort to the staining pattern, the test is performed on the ... Scientists Discover New Autoimmune Disease Developed By Testicular Cancer. At the University of California, San Francisco, ... scientists discovered that testicular cancer can cause a neurodegenerative disease. This happens because it damages the immune ... Testicular cancer. Photo: Pixabay. Faced with this pattern, the scientists set out to investigate which is the antibody that ...
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... testicular cancer is the most common solid tumor cancer diagnosed in young men. ... However, testicular cancer is considered a "young mans disease" because people under 45 are at the greatest risk. ... Testicular cancer is highly treatable Dr. Bradley Leibovich discusses testicular cancer symptoms and explains that a cure is ... Broadly, there are two categories of testicular cancer:. *Seminoma. These testicular cancers tend to happen at an older age. ...
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Testicular Torsion: Causes, Symptoms, Diagnosis & Treatment
Testicular torsion causes your testicle to twist and cuts off its blood supply. It causes severe pain and requires emergency ... How common is testicular torsion?. Testicular torsion is rare. It affects about one in 4,000 men and people AMAB under age 25. ... Can I have testicular torsion in both testicles?. Yes, you can have testicular torsion in both testicles. But its rare. Only ... What is testicular torsion?. Testicular torsion is a serious and painful condition that affects your testicle(s). If you ...
Testicular Seminoma - My Cancer Genome
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Testicular Torsion: Definition, Symptoms, and Treatment
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Developing testicular cancerDiagnosed with testicular cancerSeminomaTestesCancersPatients with testicularThyroid diseaseCause of testicular cancerIncidenceContralateral Testicular CancerChemotherapyScrotumTypes of testicularTumorCases of testicularSymptomsNonseminomaMalignancyTreatableSperm2020CryptorchidismTesticleCenters for DiseasCurableTesticlesDiagnosisSelf-examinationDisordersTestosteroneTorsion diagnosedMalignantClinicalMetastaticEndocrineKidneyOccursEmbryonal carcinomaTumorsBilateralTestisParenchymaTreatmentInflammationRisk of cardiovascular diseasePrimaryOrchiectomyOccurInguinalVasectomyProstate cancerMortalityDevelopsSurgery
Developing testicular cancer1
- by age 3 have a greater chance of developing testicular cancer than do men whose testes descended by that age. (msdmanuals.com)
Diagnosed with testicular cancer3
- Drs. Lance Pagliaro and Bradley Leibovich explain what people diagnosed with testicular cancer need to know about life after treatment. (mayoclinic.org)
- But the average age for men diagnosed with testicular cancer is 33 years old. (aia.com)
- The American Cancer Society estimates that in 2023 about 9,190 men will be diagnosed with testicular cancer, and there will be about 470 deaths. (msdmanuals.com)
Seminoma5
- Patients with stage II or III seminoma are considered to have good risk, with the exception of patients who have stage III disease with nonpulmonary visceral metastases, who are classified as intermediate-risk patients. (medscape.com)
- Seminoma: This is a slow-growing form of testicular cancer found in men in their 40s and 50s. (mountsinai.org)
- There are 2 clinical trials for testicular seminoma, of which 2 are open and 0 are completed or closed. (mycancergenome.org)
- Of the trials that contain testicular seminoma as an inclusion criterion, 1 is phase 3 (1 open) and 1 is no phase specified (1 open). (mycancergenome.org)
- Observation and surgery are the most common interventions in testicular seminoma clinical trials. (mycancergenome.org)
Testes6
- Oxidative stress and reactive oxygen species (ROS), which are majorly sourced from macrophages [ 5 ], may be the major contributory factors leading to testicular cell apoptosis and acute inflammation of testes [ 6 ]. (hindawi.com)
- Testicular mesothelioma, a rare form of the disease, affects the tunica vaginalis in the testes and accounts for less than 5% of all cases. (pleuralmesothelioma.com)
- Testicular mesothelioma forms on the membrane that lines the testes called the tunica vaginalis. (pleuralmesothelioma.com)
- Early-stage disease indicates that cancer is localized and tumors have not formed outside of the testes. (pleuralmesothelioma.com)
- Testicular cancer occurs in the testes, the 2 small organs in males that make sperm. (msdmanuals.com)
- Through an in vitro experiment exposing VERO cells to testicular macerates, we observed viral content in all samples, and the subgenomic RNA's presence reinforced the replicative activity of SARS-CoV-2 in testes of the severe COVID-19 patients. (bvsalud.org)
Cancers6
- These testicular cancers tend to happen at an older age. (mayoclinic.org)
- These testicular cancers tend to happen earlier in life. (mayoclinic.org)
- They've been linked to kidney and testicular cancers, thyroid disease, high cholesterol, pre-eclampsia and ulcerative colitis. (superlawyers.com)
- Research has shown they're linked to serious health effects that include increased risk of kidney and testicular cancers, thyroid disease and fertility issues. (wpr.org)
- Vinblastine is a major chemotherapy drug used to treat cancers such as Hodgkin's disease, testicular and breast cancers. (science.ca)
- Most testicular cancers develop in men younger than age 40. (msdmanuals.com)
Patients with testicular2
- But patients with testicular tumours overlook their condition precisely because there is no pain, further delaying a doctor's visit. (aia.com)
- Almost half of the patients with testicular mesothelioma survive for five or more years after diagnosis, while 33% survive at least 10 years. (pleuralmesothelioma.com)
Thyroid disease3
- PFAS are known to causes kidney cancer, testicular cancer and thyroid disease. (nationofchange.org)
- Numerous studies have linked the chemicals to health issues, such as thyroid disease and testicular cancer. (waff.com)
- Dr. Hershman is here to make his presentation because issues of thyroid disease and I-131 exposures are significant issues to the Subcommittee. (cdc.gov)
Cause of testicular cancer1
- The exact cause of testicular cancer is poorly understood. (mountsinai.org)
Incidence8
- [ 5 ] The overall incidence of choriocarcinoma of the testis is approximately 0.8 cases per year per 100,000 male population in countries with the highest frequency of testicular cancer. (medscape.com)
- Other features may include mild testicular enlargement and evidence of metastatic disease due to the high incidence of vascular invasion. (medscape.com)
- The average incidence of testicular cancer globally is 1.5 cases per 100,000 people. (aia.com)
- Testicular cancer, the 20th leading cancer type, had the highest incidence observed in Europe (7.2 - 8.7), followed by North America (5 - 5.6) and the lowest in Asia (0.4 - 1.7) and Africa (0.3 - 0.6). (aia.com)
- Neutering eliminates testicular cancer and decreases the incidence of prostrate disease. (siloamsprings.com)
- 1999) Incidence of testicular cancer in the United States: has the epidemic begun to abate? (medscape.com)
- Prostate cancer mortality and incidence and testicular cancer incidence were significantly elevated. (cdc.gov)
- A new study conducted by researchers from the International Agency for Research on Cancer (IARC) and collaborators quantifies the future number of new cases of testicular cancer in 28 European countries up to 2035, taking into account recent trends in incidence rates as well as demographic projections. (who.int)
Contralateral Testicular Cancer1
- 2005) Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men. (medscape.com)
Chemotherapy4
- Given that relapse after chemotherapy is quite rare in testicular cancer, a large number of recruiting centres are required to efficiently accrue patients into the study. (movember.com)
- Chemotherapy, retroperitoneal lymph node dissection, and targeted treatment of distant metastases make even widely disseminated disease treatable. (urotoday.com)
- Since the discovery of platinum-based chemotherapy, testicular germ cell tumors are a highly curable disease. (urotoday.com)
- As previously reported by Medscape Medical News, survivors of testicular cancer face a worrisome risk of developing certain metabolic effects, such as hypertension, that are tied to platinum-based chemotherapy. (medscape.com)
Scrotum1
- Testicular torsion can also occur after an injury to your testicle or scrotum. (clevelandclinic.org)
Types of testicular1
- Due to the similarity of symptoms with other types of testicular disease, diagnosing mesothelioma of the tunica vaginalis can be difficult. (pleuralmesothelioma.com)
Tumor7
- Spontaneous regression as a 'burned-out' non-seminomatous testicular germ cell tumor. (greenmedinfo.com)
- Spontaneous regression of metastatic testicular carcinoma in a patient with bilateral sequential testicular tumor. (greenmedinfo.com)
- In certain cases in which metastatic disease is uncovered, the primary tumor may no longer be visible and only a scar is seen within the testis. (medscape.com)
- The bad news is that testicular cancer is the most common solid tumor cancer diagnosed in young men. (mayoclinic.org)
- The International Germ Cell Cancer Consensus Group (IGCCCG) developed a classification system based on identifying clinically independent prognostic features, including extent of disease and levels of serum tumor markers. (medscape.com)
- A stromal tumor is a rare type of testicular tumor. (mountsinai.org)
- Increasing evidences indicate that the imbalance among these pro- and anti-inflammatory molecules, such as interleukin-1 β (IL-1 β ), IL-6, tumor necrosis factor- α (TNF- α ), and IL-10, in testicular cells can result in orchitis [ 3 , 4 ]. (hindawi.com)
Cases of testicular1
- However, 65% of all cases of testicular torsion occur in men and people AMAB between the ages of 12 and 18. (clevelandclinic.org)
Symptoms8
- Dr. Bradley Leibovich discusses testicular cancer symptoms and explains that a cure is possible for most people diagnosed with the disease. (mayoclinic.org)
- What are the symptoms of testicular torsion? (clevelandclinic.org)
- Knowing that others in your family have experienced testicular torsion can help you request emergency treatment immediately if its symptoms affect you or someone in your family. (healthline.com)
- Pain and swelling of the scrotal sac are the main symptoms of testicular torsion. (healthline.com)
- Malignant mesothelioma of the tunica vaginalis does not have a unique set of symptoms and presents similarly to more common testicular diseases. (pleuralmesothelioma.com)
- Rarely, the first symptoms of people with testicular cancer that has spread widely (metastatic cancer) are abdominal pain, low back pain, confusion or headaches, shortness of breath, and/or chest pain. (msdmanuals.com)
- Clinical and genetic factors can increase the risk for hypogonadism, and providers should screen testicular cancer survivors for hypogonadism and treat those with symptoms," he said. (medscape.com)
- Our findings underscore the need for clinicians to assess testicular cancer for physical signs or symptoms of hypogonadism and to measure testosterone in those who do," he concluded. (medscape.com)
Nonseminoma2
- Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. (mountsinai.org)
- Treatment protocols for nonseminoma testicular cancer are provided below, including recommendations for treatment of stage I-III disease, second-line recommendations for metastatic disease, and recommendations for persistent or recurrent disease. (medscape.com)
Malignancy3
- Testicular lymphoma may either represent secondary involvement by systemic disease or primary malignancy. (intechopen.com)
- 2006) Value of frozen section analysis with suspected testicular malignancy. (medscape.com)
- one study found a 64% association of testicular torsion with testicular malignancy. (medscape.com)
Treatable4
- Testicular cancer is rare and highly treatable. (medlineplus.gov)
- Testicular Cancer is a highly treatable disease. (movember.com)
- Testicular cancer is curable in its early stages, and is treatable. (mh.co.za)
- This reinforces the need to ensure the provision of effective treatment for this highly treatable disease. (who.int)
Sperm2
- Studies show that 1 in 3 people have a lower sperm count after testicular torsion. (clevelandclinic.org)
- Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
20201
- Moreover, according to research published in the International Journal of Cancer, it can strike even in the teenage years: testicular cancer was the most common cancer in men ages 15 to 44 in 62 countries worldwide in 2020. (aia.com)
Cryptorchidism1
- Correcting cryptorchidism decreases the risk of testicular cancer. (msdmanuals.com)
Testicle12
- Diagnostic evaluation of Dirofilaria repens testicular infection in a child from Italy, a boy 13 years of age who had a 5-month history of swelling in the left testicle. (cdc.gov)
- Testicular cancer usually develops in one testicle, but also can develop in both. (mayoclinic.org)
- Testicular torsion is a painful condition where your testicle twists and loses its blood supply. (clevelandclinic.org)
- A testicular torsion occurs when your spermatic cord twists, cutting off blood supply to your testicle. (clevelandclinic.org)
- Testicular torsion is a serious and painful condition that affects your testicle(s) . (clevelandclinic.org)
- If you experience testicular torsion, the spermatic cord twists and cuts off blood flow to your testicle. (clevelandclinic.org)
- In most people, testicular torsion feels like a sudden, intense pain in your testicle that sometimes extends to your stomach or makes you feel like you're going to throw up. (clevelandclinic.org)
- In others, testicular torsion is an intense pain in your testicle that goes away and comes back. (clevelandclinic.org)
- Testicular torsion usually occurs in only one testicle. (healthline.com)
- Most young adult males think testicular cancer, which develops in the testicle or testis, will develop in their 60s (if at all), like prostate cancer. (aia.com)
- Testicular torsion refers to the torsion of the spermatic cord structures and subsequent loss of the blood supply to the ipsilateral testicle. (medscape.com)
- Testicular torsion is caused by twisting of the spermatic cord and the blood supply to the testicle (see the image below). (medscape.com)
Centers for Diseas5
- Centers for Disease Control and Prevention. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- The MMWR series of publications is published by the Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30329-4027. (cdc.gov)
- Seeking to address this critical health issue, a multidisciplinary group of experts convened by The Endocrine Society and the US Centers for Disease Control and Prevention just issued recommendations for improving and standardizing testosterone testing in a consensus statement to be published in the October 2010 issue of The Endocrine Society's Journal of Clinical Endocrinology & Metabolism ( JCEM ). (scienceblog.com)
- Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
Curable3
- Overall, testicular cancer is highly curable. (mayoclinic.org)
- Testicular cancer is most common among young men but usually curable. (msdmanuals.com)
- Testicular cancer occurs at a young age and is highly curable, and patients can expect to live for 40 years after their diagnosis, but there is a long-term risk for late complications from treatment," said lead study author Mohammad Issam Abu Zaid, MBBS, an assistant professor of medicine at the Indiana University School of Medicine in Indianapolis. (medscape.com)
Testicles6
- Testicular cancer is the abnormal growth of cells in the testicles, which are located in the loose bag of skin underneath the penis. (mayoclinic.org)
- Testicular cancer is cancer that starts in the testicles. (mountsinai.org)
- Can I have testicular torsion in both testicles? (clevelandclinic.org)
- Only about 2% of testicular torsion cases affect both testicles. (clevelandclinic.org)
- The main symptom of testicular torsion is sudden, severe pain in one of your testicles. (clevelandclinic.org)
- Testicular torsion can affect anyone who has testicles. (clevelandclinic.org)
Diagnosis3
- Because human dirofilariasis is emerging in southern and eastern Europe, this parasitic infection should be considered in the differential diagnosis of scrotal swelling in disease-endemic countries to avoid unnecessary interventions, such as orchiectomy. (cdc.gov)
- These recommendations complement CDC's Sexually Transmitted Diseases Treatment Guidelines, 2015 (hereafter referred to as the STD Guidelines ) , a comprehensive, evidence-based reference for prevention, diagnosis, and treatment of STDs. (cdc.gov)
- Diagnosis of testicular torsion is clinical, and diagnostic testing should not delay treatment. (medscape.com)
Self-examination1
- Testicular self-examination: a public awareness program. (cdc.gov)
Disorders1
- Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73725/9.0/Testicular_Cancer. (unboundmedicine.com)
Testosterone4
- Chevy Chase, MD - The use of testosterone assays for patient care and research is on the rise as new research links testosterone to a variety of diseases and conditions. (scienceblog.com)
- Peyronie's disease, low testosterone, testicular pain and other problems involving men's genitalia. (mhs.net)
- CHICAGO - A substantial percentage of testicular cancer survivors have low testosterone levels, which in turn puts them at risk for a plethora of chronic health conditions, including hypertension , diabetes, erectile dysfunction , anxiety , and depression , according to findings from a large multicenter study. (medscape.com)
- Although it's been known for some time that low testosterone levels occur in a significant proportion of survivors of testicular cancer, the current study is one of the first to examine its relationship with long-term health complications in North American patients. (medscape.com)
Torsion diagnosed1
- How is testicular torsion diagnosed? (clevelandclinic.org)
Malignant1
- Regarding primary testicular lymphoma (PTL), it is a rare form of extranodal lymphoma and the most frequent malignant testicular neoplasm in men over the age of 60 years. (intechopen.com)
Clinical5
- Learn more about testicular cancer and find a testicular cancer clinical trial at Mayo Clinic. (mayoclinic.org)
- The TIGER trial is a very large multinational clinical trial investigating which of the two current and commonly used treatments is more effective in preventing death in men who show a relapse of testicular cancer. (movember.com)
- This report (hereafter referred to as STD QCS ) provides CDC recommendations to U.S. health care providers regarding quality clinical services for sexually transmitted diseases (STDs) for primary care and STD specialty care settings. (cdc.gov)
- Study supports the role of PSMA PET for risk stratifying patients with clinically node-positive disease before radical prostatectomy, along with mpMRI and clinical parameters. (renalandurologynews.com)
- 2003) Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: the Memorial Sloan Kettering Cancer Center experience 1950 to 2001. (medscape.com)
Metastatic3
- A case of spontaneous regression of metastatic testicular teratoma. (greenmedinfo.com)
- CT scanning has been shown to be the most sensitive method of assessing metastatic disease within the thorax, abdomen, and pelvis. (medscape.com)
- Positron emission tomography (PET) scanning is an emerging diagnostic imaging technique used to assess for metastatic disease. (medscape.com)
Endocrine1
- however, endocrine factors of the hypothalamic-pituitary-testicular axis also play a major role in this process. (medscape.com)
Kidney1
- Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
Occurs1
- Choriocarcinoma occurs within the testicular parenchyma, with no predilection to a particular site. (medscape.com)
Embryonal carcinoma1
- Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. (greenmedinfo.com)
Tumors6
- Choriocarcinoma is extremely rare in its pure form, constituting less than 1% of testicular tumors. (medscape.com)
- Testicular germ cell tumors make up 0.5% of pediatric malignancies, and 14% of adolescent malignancies. (urotoday.com)
- 2002) Bilateral testicular germ cell tumors. (medscape.com)
- 2005) Management and outcome of bilateral testicular germ cell tumors: twenty-five year experience in Munich. (medscape.com)
- 1988) Simultaneous bilateral testicular germ cell tumors with dissimilar histology: case report and review of the literature. (medscape.com)
- 1995) A conservative approach to bilateral testicular germ cell tumors. (medscape.com)
Bilateral2
- 1995) Bilateral synchronous testicular germ cell cancer. (medscape.com)
- 2006) Management of bilateral testicular germ cell tumours-experience of the German Testicular Cancer Study Group (GTCSC) [abstract]. (medscape.com)
Testis5
- Guidelines for the Implementation of a Testis-sparing Approach to Testicular Cancer. (medscape.com)
- Testicular cancer may cause an enlarged testis or a lump. (msdmanuals.com)
- Although testicular cancer is usually painless, the testis or lump may hurt when lightly touched and may even hurt without being touched. (msdmanuals.com)
- The initial treatment for testicular cancer is surgical removal of the entire affected testis (radical orchiectomy). (msdmanuals.com)
- RESULTS: We found that SARS-CoV-2 testicular tropism is higher than previously thought and that reliable viral detection in the testis requires sensitive nanosensors or RT-qPCR using a specific methodology. (bvsalud.org)
Parenchyma1
- Moreover, we showed infiltrative infected monocytes migrating into the testicular parenchyma. (bvsalud.org)
Treatment7
- Polyunsaturated fatty acids may have a preventive and thereapeutic role in the treatment of testicular cancer. (greenmedinfo.com)
- Before treatment for testicular cancer, a patient should discuss fertility with their health care team. (mayoclinic.org)
- Despite being the 2nd most common cancer in young men, testicular cancer is often a forgotten cancer due to early detection and treatment. (movember.com)
- Therefore, methane exerts therapeutic effects on acute orchitis and might be a new and convenient strategy for the treatment of inflammation-related testicular diseases. (hindawi.com)
- However, determining how far the disease has progressed is an essential step in developing a treatment plan. (pleuralmesothelioma.com)
- Peyronie disease may resolve over several months without treatment. (merckmanuals.com)
- In view of this newly identified Dmrt1- Spry1-NF-κB axis mechanism in the regulation of testicular immune homeostasis, our study opens new avenues for the prevention and treatment of male reproductive diseases in humans and livestock. (bvsalud.org)
Inflammation1
- Additionally, it has been shown that the PK2/PKR1 pathway contributes to the development of testicular inflammation [ 7 - 9 ]. (hindawi.com)
Risk of cardiovascular disease2
- Kathrine Rugbjerg, PhD, of the Danish Cancer Society, discusses her findings on the risk of cardiovascular disease and hospitalizations in Danish survivors of cancer during their adolescence and young adulthood. (ascopost.com)
- The risk of cardiovascular disease and of diseases associated with alcohol and tobacco use were significantly decreased. (cdc.gov)
Primary1
- Primary testicular disease often shows a hypoechoic pattern on ultrasonograms. (medscape.com)
Orchiectomy2
- In testicular cancer post-orchiectomy, markers are used to determine risk classification. (medscape.com)
- 1999) Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. (medscape.com)
Occur2
- Most testicular torsion cases occur in people who have a "bell clapper" deformity. (clevelandclinic.org)
- Testicular torsion can occur when you're sleeping or engaging in physical activity. (healthline.com)
Inguinal1
- This rare form of cancer can be mistaken for more common conditions such as an inguinal hernia or testicular adenocarcinoma. (pleuralmesothelioma.com)
Vasectomy1
- There is no link between vasectomy and testicular cancer. (mountsinai.org)
Prostate cancer1
- The author notes that a possible recommendation from these findings would be to include screening of male pesticide applicators for testicular and prostate cancer, and screening of female pesticide applicators for cervical cancer, as well as providing specific risk avoidance instruction for aerial applicators. (cdc.gov)
Mortality1
- Cancer is globally a disease of significant public health concern owing to its prevalence, and association with morbidity and mortality. (researchgate.net)
Develops2
- It's unclear why testicular cancer develops. (mayoclinic.org)
- Testicular mesothelioma develops as hard yellowish lesions on the surface of the tunica vaginalis. (pleuralmesothelioma.com)
Surgery2
- Doctors often diagnose the disease incidentally after an examination or surgery for another indication. (pleuralmesothelioma.com)
- Surgery is not recommended unless the disease has progressed and the curvature has become too severe for successful intercourse. (merckmanuals.com)