Testicular Neoplasms
Dysgerminoma
Seminoma
Pancreatic Neoplasms
Neoplasms
Incidence and occupational pattern of leukaemias, lymphomas, and testicular tumours in western Ireland over an 11 year period. (1/2042)
STUDY OBJECTIVE: To determine incidence of the following malignancies, testicular tumours, all leukaemias and all lymphomas in the West of Ireland in an 11 year period. Secondly, to examine the relation between disease patterns and available occupational data in male subjects of working age. DESIGN: A census survey of all cases occurring in the three counties in the Western Health Board (WHB) area, Galway, Mayo and Roscommon, for the 11 year period 1980 to 1990 inclusive. Average annual age standardised incidence rates for the period were calculated using the 1986 census data. Rates for the area are compared with rates from the southern region of Ireland, which had a tumour registry. Trends over the time period are evaluated. All male subjects for whom occupational data were available were categorised using the Irish socioeconomic group classification and incidence rates by occupation were compared using the standardised incidence ratio method. In one of the counties, Galway, a detailed occupational history of selected cases and an age matched control group was also elicited through patients' general practitioners. SETTING: All available case records in the West of Ireland. RESULTS: There are no national incidence records for the period. Compared with data from the Southern Tumour Registry, the number of cases of women with myeloid leukaemias was significantly lower. Male leukaemia rates were significantly lower as a group (SIR 84 (95% CI 74, 95) but not when considered as individual categories. Regression analysis revealed an increasing trend in the number of new cases of non-Hodgkin's lymphoma among both men (r = 0.47, p = 0.02) and women (r = 0.90, p = 0.0001) and of chronic lymphocytic leukaemia in men (r = 0.77, p = 0.005) and women (r = 0.68 p = 0.02) in the WHB region over the last decade. Four hundred and fifty six male cases over the age of 15 years were identified and adequate occupational information was available for 74% of these. Standardised incidence ratios of testicular tumours 100, 938) and agriworkers other than farmers (SIR 377, 95% CI 103, 967). There were also significantly increased incidence ratios for both non-Hodgkin's lymphoma (SIR 169, 95% CI 124, 266) and three categories of leukaemias among farmers. Hodgkin's disease and acute myeloid leukaemias were significantly increased among semi-skilled people. Interview data with 90 cases and 54 controls of both sexes revealed that among farmers, cases (n = 31) were significantly less likely than controls (n = 20) to use tractor mounted spraying techniques (OR = 0.19 (95% CI 0.04, 0.80)) and less likely to wear protective masks (OR 0.22 (95% CI 0.05, 0.84)). CONCLUSIONS: Trends of increase in non-Hodgkin's lymphoma and some leukaemias are consistent with studies elsewhere. The study provides further evidence of the relation between agricultural work and certain lymphoproliferative cancers. The possible carcinogenic role of chemicals used in agricultural industries must be considered as an explanation. (+info)Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. (2/2042)
The Mdm2 protein is frequently overexpressed in human non-seminomatous germ cell tumours and transitional carcinoma of the bladder where it may contribute to tolerance of wtp53. Mdm2 forms an autoregulatory feedback loop with p53; the Mdm2 gene is responsive to transactivation by p53 and once synthesized the Mdm2 protein terminates the p53 response. We show here that the topoisomerase poison etoposide, like ultra violet irradiation, inhibits Mdm2 synthesis. Cytotoxic concentrations of etoposide (IC90 for > 3 h) result in inhibition of Mdm2 induction at both the RNA and protein level. Rapid apoptosis ensues. Global transcription is not inhibited: p21waf-1/cip1 and GADD45 expression increase in a dose dependent manner. Inhibition of Mdm2 synthesis depends on the continuous presence of etoposide, suggesting the DNA damage may prevent transcription. Downregulation of Mdm2 transcript occurs in cells expressing HPV16-E6 suggesting that inhibition of Mdm2 transcription is p53-independent. When cells are -treated with a pulse (1 h) of etoposide and reincubated in drug free medium, Mdm2 synthesis commences immediately after damage is repaired (3 h) and the p53 response is attenuated. Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment conditions. This is the first observation of inhibition of Mdm2 transcription following treatment with topoisomerase (topo II) poisons, a feature that may be useful in tumour types where p53 is tolerated by overexpression of Mdm2. (+info)Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. (3/2042)
Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to environmental carcinogens. To test the importance of nucleotide excision repair in protection against chemical carcinogenesis in internal organs, we treated XPC mutant (XPC-/-) mice with 2-acetylaminofluorene and NOH-2-acetylaminofluorene. We observed a significantly higher incidence of chemically induced liver and lung tumors in XPC-/- mice compared with normal and heterozygous littermates In addition, the progression of liver tumors in XPC-/- Trp53+/- mice is accelerated compared with XPC-/- Trp53+/+ animals. Finally, we demonstrate a higher incidence of spontaneous testicular tumors in XPC-/- TrpS3-/- double mutant mice compared with XPC+/+ Trp53-/- mice. (+info)Risk of testicular cancer in subfertile men: case-control study. (4/2042)
OBJECTIVE: To evaluate the association between subfertility in men and the subsequent risk of testicular cancer. DESIGN: Population based case-control study. SETTING: The Danish population. PARTICIPANTS: Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated. OUTCOME MEASURE: Occurrence of testicular cancer. RESULTS: A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors. CONCLUSION: These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors. (+info)Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis. (5/2042)
Testicular germ cell tumours are hypersentive to chemotherapy and cell lines derived from these tumours are chemosensitive in vitro. We have previously shown that these cell lines express undetectable levels of the suppressor of apoptosis Bcl-2 and relatively high levels of the apoptosis inducer Bax (Chresta et al., 1996). To determine whether the absence of Bcl-2 in these cell lines makes them highly susceptible to drug-induced apoptosis, Bcl-2 was expressed ectopically in the 833K testicular germ cell tumour cell line. Stable overexpressing clones were isolated and three clones were studied further. Surprisingly, Bcl-2 overexpressing cells were sensitized to chemotherapy-induced apoptosis compared to the parental and vector control cells. Analysis of potential mechanisms of sensitization revealed there was a reciprocal downregulation of the endogenously expressed Bcl-X(L) in the Bcl-2 overexpressing clones. Downregulation of Bcl-X(L) to the same extent using antisense oligonucleotides enhanced etoposide-induced apoptosis by twofold. Our results indicate that Bcl-2 and Bcl-X(L) have different abilities to protect against chemotherapy-induced apoptosis in testicular germ cell tumours. In contrast to findings in some tumour cell types, Bcl-2 did not act as a gatekeeper to prevent entry of p53 to the nucleus. (+info)Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia. (6/2042)
In addition to their role in steroidogenesis in the male, testicular Leydig cells constitutively express large amounts of the peptide relaxin-like factor (RLF), also known as Ley-IL. The Leydig cell-derived RLF belongs to the insulin-like superfamily, which also includes relaxin, insulin and the insulin-like growth factors, and within the testis is a specific marker of Leydig cells. Little information is available either on the regulation of gene expression or on the function of this Leydig cell-derived peptide. In the present study we have investigated the expression pattern of human RLF in patients with rare Leydig cell hyperplasia and adenoma. The expression of both mRNA and protein appear to be decreased in hyperplastic Leydig cells, whereas in the Leydig cell adenomas studied, large central areas of the adenoma were devoid of RLF mRNA and protein. Only Leydig cells located at the periphery of the adenoma displayed expression of RLF, with full agreement between in-situ hybridization and immunohistochemistry. It thus appears that the expression of the RLF gene and its products are down-regulated in Leydig cell hyperplasia and adenoma, consistent with a concomitant dedifferentiation of these cells. (+info)Testicular cancer: an oncological success story. (7/2042)
Testicular cancer has become a model for a curable neoplasm. Our studies with cisplatin combination chemotherapy allow us to conclude that: (a) short-duration intensive induction therapy with the most active agents in optimal dosage is more important than maintenance therapy; (b) modest dose escalation increases toxicity without improving therapeutic efficacy; (c) it is possible to develop curative salvage therapy for refractory germ cell tumors; and (d) preclinical models predicting synergism, such as vinblastine + bleomycin or cisplatin + etoposide have clinical relevance. Finally, testicular cancer has also become a model for new drug development. Cisplatin was approved by the Food and Drug Administration for testis and ovarian cancer, and etoposide and ifosfamide were approved for refractory germ cell tumors. The success of these studies confirms the importance of the continued search for new investigational drugs in all solid tumors. (+info)Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. (8/2042)
PURPOSE: To obtain information about preorchiectomy gonadal function in patients with testicular germ cell cancer to improve the clinical management of fertility and other andrologic aspects in these men. PATIENTS AND METHODS: In group 1, a group of 83 consecutive patients with testicular germ cell cancer (TGCC) investigated before orchiectomy, semen analysis was carried out in 63 patients and hormonal investigations, including measurement of follicle-stimulating hormone, luteinizing hormone (LH), testosterone, estradiol, sex hormone-binding globulin (SHBG), inhibin B, and human chorionic gonadotropin (hCG), in 71 patients. Hormone levels in patients with elevated hCG (n = 41) were analyzed separately. To discriminate between general cancer effects and specific effects associated with TGCC, the same analyses were carried out in a group of 45 consecutive male patients with malignant lymphoma (group 2). Group 3 comprised 141 men employed in a Danish company who served as controls in the comparison of semen parameters. As a control group in hormone investigations, 193 men were selected randomly from the Danish National Personal Register to make up group 4. RESULTS: We found significantly lower sperm concentration (median, 15 x 10(6)/mL; range, 0 to 128 x 10(6)/mL) and total sperm count (median, 29 x 10(6)/mL; range, 0 to 589 x 10(6)) in patients with testicular cancer than in patients with malignant lymphomas (sperm concentration: median, 48 x 10(6)/mL; range, 0.04 to 250 x 10(6)/mL; sperm count: median, 146 x 10(6); range, 0.05 to 418 x 10(6)) (P < .001 and P < .001) and healthy men (sperm concentration: median, 48 x 10(6)/mL; range, 0 to 402 x 10(6)/mL; sperm count: median, 162 x 10(6); range, 0 to 1253 x 10(6)) (P < .001 and P < .001). FSH levels were increased in men with testicular cancer (median, 5.7 IU/L; range, 2.0 to 27 IU/L) compared with both men with malignant lymphomas (median, 3.3 IU/L; range, 1.01 to 12.0 IU/L) and healthy controls (median, 4.1 IU/L; range, 1.04 to 21 IU/L)(P = .001 and P = .007, respectively). Surprisingly, we found significantly lower LH in the group of men with TGCC (median, 3.6 IU/L; range, 1.12 to 11.9 IU/L) than in healthy men (median, 4.7 IU/L; range, 1.3 to 11.9 IU/L) (P = .01). We could not detect any differences between men with testicular cancer and men with malignant lymphomas and healthy men with regard to serum levels of testosterone, SHBG, and estradiol. Men with testicular cancer who had increased hCG levels had significantly lower LH and significantly higher testosterone and estradiol than those without detectable hCG levels. CONCLUSION: Spermatogenesis is already impaired in men with testicular cancer before orchiectomy. Neither local suppression of spermatogenesis by tumor pressure nor a general cancer effect seems to fully explain this impairment. The most likely explanation is preexisting impairment of spermatogenesis in the contralateral testis in men with testicular cancer. The question of whether also a pre-existing Leydig cell dysfunction is present in men with testicular cancer could not be answered in this study because the tumor seems to have a direct effect on the Leydig cells. Men with testicular cancer had low LH values as compared with controls. We speculate that increased intratesticular level of hCG also in men without measurable serum hCG may play a role by exerting LH-like effects on the Leydig cells, causing increased testosterone and estrogen levels and low LH values in the blood. (+info)Testicular neoplasms are abnormal growths or tumors in the testicle that can be benign (non-cancerous) or malignant (cancerous). They are a type of genitourinary cancer, which affects the reproductive and urinary systems. Testicular neoplasms can occur in men of any age but are most commonly found in young adults between the ages of 15 and 40.
Testicular neoplasms can be classified into two main categories: germ cell tumors and non-germ cell tumors. Germ cell tumors, which arise from the cells that give rise to sperm, are further divided into seminomas and non-seminomas. Seminomas are typically slow-growing and have a good prognosis, while non-seminomas tend to grow more quickly and can spread to other parts of the body.
Non-germ cell tumors are less common than germ cell tumors and include Leydig cell tumors, Sertoli cell tumors, and lymphomas. These tumors can have a variety of clinical behaviors, ranging from benign to malignant.
Testicular neoplasms often present as a painless mass or swelling in the testicle. Other symptoms may include a feeling of heaviness or discomfort in the scrotum, a dull ache in the lower abdomen or groin, and breast enlargement (gynecomastia).
Diagnosis typically involves a physical examination, imaging studies such as ultrasound or CT scan, and blood tests to detect tumor markers. Treatment options depend on the type and stage of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these modalities. Regular self-examinations of the testicles are recommended for early detection and improved outcomes.
Testicular diseases refer to a range of conditions that affect the testicles, the male reproductive organs located in the scrotum. These diseases can affect either one or both testicles and may cause pain, swelling, or impact fertility. Here are some examples of testicular diseases:
1. Testicular cancer: A malignant tumor that develops in the testicle. It is a relatively rare cancer but is highly treatable if detected early.
2. Testicular torsion: A surgical emergency that occurs when the spermatic cord, which supplies blood to the testicle, becomes twisted, cutting off the blood flow.
3. Epididymitis: An infection or inflammation of the epididymis, a coiled tube that stores and carries sperm from the testicle.
4. Orchitis: An infection or inflammation of the testicle itself. It can occur on its own or as a complication of mumps.
5. Hydrocele: A fluid-filled sac that forms around the testicle, causing swelling.
6. Varicocele: Enlarged veins in the scrotum that can cause pain and affect fertility.
7. Inguinal hernia: A condition where a portion of the intestine or fat protrudes through a weakened area in the abdominal wall, often appearing as a bulge in the groin or scrotum.
8. Testicular trauma: Injury to the testicle, which can result from accidents, sports injuries, or other causes.
9. Undescended testicles: A condition where one or both testicles fail to descend from the abdomen into the scrotum before birth.
It is essential for men to perform regular self-examinations to check for any unusual lumps, swelling, or pain in the testicles and seek medical attention if they notice any changes.
Dysgerminoma is a type of germ cell tumor that develops in the ovaries. It is a malignant (cancerous) tumor that primarily affects girls and women of reproductive age, although it can occur at any age. Dysgerminomas are composed of large, round, or polygonal cells with clear cytoplasm and distinct cell borders, arranged in nests or sheets. They may also contain lymphoid aggregates and may produce hormones such as estrogen or testosterone.
Dysgerminomas are usually unilateral (affecting one ovary), but they can be bilateral (affecting both ovaries) in about 10-15% of cases. They tend to grow and spread rapidly, so early detection and treatment are crucial for a favorable prognosis.
The standard treatment for dysgerminoma is surgical removal of the affected ovary or ovaries, followed by chemotherapy with agents such as bleomycin, etoposide, and cisplatin (BEP). With appropriate treatment, the five-year survival rate for patients with dysgerminoma is high, ranging from 80% to 95%.
Seminoma is a type of germ cell tumor that develops in the testicle. It is a malignant tumor, meaning it can spread to other parts of the body if left untreated. Seminomas are typically slow-growing and tend to remain localized to the testicle for a longer period compared to other types of testicular cancer. They usually occur in men between the ages of 25 and 45 but can develop at any age.
Seminomas can be classified into two main subtypes: classical seminoma and spermatocytic seminoma. Classical seminoma is more common and typically responds well to treatment, while spermatocytic seminoma is rarer and tends to have a better prognosis with a lower risk of spreading.
Seminomas are usually treated with surgery to remove the affected testicle (orchiectomy), followed by radiation therapy or chemotherapy to kill any remaining cancer cells. The prognosis for seminoma is generally good, especially when caught and treated early. Regular self-examinations of the testicles can help detect any lumps or abnormalities that may indicate the presence of a seminoma or other type of testicular cancer.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.
Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.
Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.
Neoplasms: Neoplasms refer to abnormal growths of tissue that can be benign (non-cancerous) or malignant (cancerous). They occur when the normal control mechanisms that regulate cell growth and division are disrupted, leading to uncontrolled cell proliferation.
Cystic Neoplasms: Cystic neoplasms are tumors that contain fluid-filled sacs or cysts. These tumors can be benign or malignant and can occur in various organs of the body, including the pancreas, ovary, and liver.
Mucinous Neoplasms: Mucinous neoplasms are a type of cystic neoplasm that is characterized by the production of mucin, a gel-like substance produced by certain types of cells. These tumors can occur in various organs, including the ovary, pancreas, and colon. Mucinous neoplasms can be benign or malignant, and malignant forms are often aggressive and have a poor prognosis.
Serous Neoplasms: Serous neoplasms are another type of cystic neoplasm that is characterized by the production of serous fluid, which is a thin, watery fluid. These tumors commonly occur in the ovary and can be benign or malignant. Malignant serous neoplasms are often aggressive and have a poor prognosis.
In summary, neoplasms refer to abnormal tissue growths that can be benign or malignant. Cystic neoplasms contain fluid-filled sacs and can occur in various organs of the body. Mucinous neoplasms produce a gel-like substance called mucin and can also occur in various organs, while serous neoplasms produce thin, watery fluid and commonly occur in the ovary. Both mucinous and serous neoplasms can be benign or malignant, with malignant forms often being aggressive and having a poor prognosis.
Leydig cell hypoplasia
Plicamycin
Maurice Chevassu
Testicular sarcoidosis
Splenogonadal fusion
Transillumination
Dactinomycin
List of MeSH codes (C19)
List of MeSH codes (C12)
Testicle
Henry Harrington Janeway
Hematospermia
Urogenital neoplasm
Gynecomastia
Adenomatoid tumor
Primordial germ cell migration
GPER
Seminoma
Rete tubular ectasia
Endodermal sinus tumor
Small supernumerary marker chromosome
Turner syndrome
Primrose syndrome
H19 (gene)
Oligospermia
Laboratory rat
Adjuvant therapy
IGF2BP2
Spermatocele
Male infertility
Researchers interested in Testicular Neoplasms | Yale School of Medicine
PGS Catalog - testicular neoplasm [EFO:0004281] (Polygenic Trait)
Testicular cancer: MedlinePlus Medical Encyclopedia
Leydig cell hypoplasia - Wikipedia
Testicular Cancer | Testicular Cancer Symptoms | MedlinePlus
Prepubertal Testicular and Paratesticular Tumors: Practice Essentials, Pathophysiology, Etiology
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT)
Pathology Case Reports, Elsevier E-Book on VitalSource, 1st Edition - 9780323754927
Vinblastine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
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Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an...
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Simultaneously Detected Bilateral Testicular Cancer of Different Histopathological Origin
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Seminoma | Harvard Catalyst Profiles | Harvard Catalyst
Giant Sertoli cell nodule of the testis: distinction from other Sertoli cell lesions | Journal of Clinical Pathology
Fetal Age & Pregnancy Test In Charlotte | Any Lab Test Now
Testicular teratoma presenting as a transilluminating scrotal mass - Fingerprint - Penn State
Tumors28
- Mithramycin (NSC 24559) therapy of testicular tumors. (nih.gov)
- Chemotherapy of testicular tumors. (nih.gov)
- Chemotherapeutic treatment regimens for germinal testicular tumors]. (nih.gov)
- Radical orchiectomy has been the gold standard for testicular cancer, but partial orchiectomy has become an accepted approach to benign prepubertal testicular tumors. (medscape.com)
- The 2021 European Association of Urology (EAU) guidelines on pediatric urology recommended a partial orchiectomy as the primary approach to prepubertal testicular tumors with a favorable preoperative diagnosis on ultrasonography (US). (medscape.com)
- Routine dissection of the retroperitoneal lymph nodes is not performed to manage prepubertal testicular tumors. (medscape.com)
- The incidence of metastases to the retroperitoneal lymph nodes is lower for these tumors than for postpubertal testicular tumors. (medscape.com)
- 3. Synchronous bilateral testicular tumors. (nih.gov)
- 11. Best cases from the AFIP: bilateral testicular tumors: seminoma and mixed germ cell tumor. (nih.gov)
- Testicular germ cell tumors arise in the absence of sex-specific differentiation. (nih.gov)
- Testicular tumors may arise in males of nearly any age but are most often seen in men 20-34 years old. (medscape.com)
- Of the three main types of testicular cancer, nonseminomatous germ cell tumors (NSGCTs) are second only to seminomas in terms of frequency. (medscape.com)
- Tumor histology (see Histologic Findings ) and tumor stage (see Staging ) are of primary importance in determining the prognosis for patients with testicular tumors. (medscape.com)
- Germ cell tumors ( GERMINOMA ) of the testis constitute 95% of all testicular neoplasms. (bvsalud.org)
- Adenomatoid tumors represent 30% of the tumors of the testicular adnexa and 60% of benign tumors of these structures. (medscape.com)
- on rare occasions, it may extend to the testicular parenchyma (most often tumors of the upper pole). (medscape.com)
- We investigated the prevalence, magnitude and phenotype of CTAg-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). (birmingham.ac.uk)
- Comparative genomic hybridization (CGH) was carried out on 15 primary testicular germ cell tumors (TGCT) of adolescents and adults and two metastatic residual tumors after chemotherapeutic treatment. (prinsesmaximacentrum.nl)
- Two cases of plasmacytoma of the testis presenting as primary testicular tumors are presented. (houstonmethodist.org)
- Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors. (nih.gov)
- Testicular tumors are considered one of the most common tumors in older intact (unneutered) male dogs. (furrycritter.com)
- Sertoli cell tumors show symptoms of swelling of the testicular and scrotal area. (furrycritter.com)
- Testicular tumors are most common in intact (unneutered) older male dogs. (furrycritter.com)
- The current cause of testicular tumors is unknown. (furrycritter.com)
- The prognosis for testicular tumors that have metastasized is more guarded and the outcome varies widely depending on location, type, and treatment. (furrycritter.com)
- However, cryptorchidism, which is a well-known risk factor of testicular germ cell tumors, are the most frequent malformations associated with SGF. (bvsalud.org)
- Retroperitoneal lymph node dissection (RPLND) is an established treatment for testicular germ cell tumors with minimal late morbidity although little data exist on its efficacy in early metastatic seminoma. (bvsalud.org)
- Hopps CV, Goldstein M. Ultrasound guided needle localization and microsurgical exploration for incidental nonpalpable testicular tumors. (sbvjournals.com)
Primary testicular2
- Most primary testicular neoplasm in dogs are benign. (asiahomes.com)
- Follow-up of patients with prior primary testicular neoplasms, leukemia, or lymphoma. (medscape.com)
Metastasis3
- This entity is described as the retroperitoneal metastasis of a burned-out testicular tumor. (tjtes.org)
- Dogs suspected of a testicular tumor should also have abdominal and chest x-rays to check for metastasis as well as a chemical panel and a blood count. (furrycritter.com)
- Because of the success of testicular removal and the low rate of metastasis, castration is often the only treatment needed. (furrycritter.com)
Chemotherapy8
- There's also an increased risk of leukemia and myelodysplastic syndrome (MDS) after chemotherapy for testicular cancer. (cancer.org)
- Because of advances in diagnostic procedures, sophisticated radiation techniques and especially the introduction of cisplatin based chemotherapy protocols together with advanced postchemotherapy surgical techniques, curability is expected in about 95% of all patients diagnosed with testicular cancer and over 70% of patients with advanced disease. (nih.gov)
- This study is a retrospective analysis of testicular cancer patients from 2014 to 2020 who have received salvage chemotherapy treatment at Tata Memorial Centre. (ecancer.org)
- A total of 46 testicular cancer patients from 2014 to 2020, who received second-line chemotherapy, were analysed from the database maintained at our hospital. (ecancer.org)
- Second-line chemotherapy in testicular germ cell tumours can result in long-term disease control and all patients who are fit to tolerate second-line therapy should be offered it. (ecancer.org)
- Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)
- PURPOSE: The long-term toxicities of chemotherapy and radiotherapy can represent a significant burden to testicular cancer survivors. (bvsalud.org)
- This includes when the female partner is over age 35, when there has been a history of infertility in a prior relationship or when there are other risk factors which may cause fertility problems (e.g. cryptorchidism, testicular neoplasm, chemotherapy, radiation therapy). (weillcornell.org)
Patients with testicular3
- Spontaneous T-cell immunity against CTAg proteins therefore develops in many patients with testicular cancer and may play an important role in the excellent clinical outcome of patients with this tumor subtype. (birmingham.ac.uk)
- MRI excluded focal abnormalities in 10 patients with testicular microlithiasis, in 3 with chronic orchitis, and in 4 with atrophic involution. (medscape.com)
- PATIENTS AND METHODS: Twelve sites in the United States and Canada prospectively enrolled adult patients with testicular seminoma and isolated retroperitoneal lymphadenopathy (1-3 cm). (bvsalud.org)
Scrotum7
- Trans-scrotal biopsy or a scrotal approach to orchiectomy should never be performed in cases of suspected neoplasm, as it can cause contamination of the scrotum and alter patterns of lymphatic spread of tumor as well as complicate subsequent management. (medscape.com)
- Testicular trauma is uncommon because of its anatomic location and the mobility of testes within the scrotum. (medscape.com)
- Penetrating injuries to the scrotum should undergo surgical exploration, as over 50% of cases will have testicular rupture. (medscape.com)
- In a retrospective study of 298 boys with acute scrotum suggesting testicular torsion, color Doppler ultrasonography had a 96.8% sensitivity, 97.9% specificity, 92.1% positive predictive value, and 99.1% negative predictive value for testicular torsion. (medscape.com)
- According to Waldert et al, approximately 20% of boys who present with acute scrotum have testicular torsion, and color Doppler is a reliable modality for making the diagnosis. (medscape.com)
- High resolution real time etiologies of painful scrotum (spermatic ultrasound equipment appears to be the cord torsion vs. acute epididymoorchitis [3] best for optimal imaging of superficial and determining testicular integrity in small parts like scrotum. (gotomydoctor.com)
- Ultrasonography (USG) is was done on Toshiba equipment using 9 also helpful in determining testicular size, and 11 MHz high resolution linear transducer for scrotum 3.5 MHz transducer demonstrating occult testicular neoplasm. (gotomydoctor.com)
Cryptorchidism2
Linked with Testicular Cancer1
- Testicular Microlithiasis: Is It Linked with Testicular Cancer? (medlineplus.gov)
Tumours2
Retroperitoneal1
- Surgery in early metastatic seminoma is a prospective phase II single-arm, multi-institutional trial of RPLND as first-line treatment for testicular seminoma with clinically low-volume retroperitoneal lymphadenopathy. (bvsalud.org)
Disease5
- Testicular ultrasonography (also called scrotal ultrasonography) is the primary diagnostic modality for the evaluation of testicular and scrotal disease. (medscape.com)
- Evaluation of scrotal pain, including but not limited to testicular trauma, ischemia/torsion, and infectious or inflammatory scrotal disease. (medscape.com)
- Conclusion Testicular cancer is a rare disease which mainly affects young Malay males. (usm.my)
- Young men with back pain should be examined for testicular disease and should also be asked about past testicular abnormalities. (ox.ac.uk)
- USG is also helpful for follow up After explaining the procedure to patients in their vernacular language and orchidectomy for recurrent testicular obtaining consent from them, procedure neoplasm, staging the malignant disease were started. (gotomydoctor.com)
Therapy in testicular1
- Mithramycin therapy in testicular cancer. (nih.gov)
Cases with testicular2
- In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. (nih.gov)
- Three cases with testicular rupture were diagnosed accurately, with interruption of the dark signal intensity line of the tunica albuginea being pathognomonic for the diagnosis of testicular rupture. (medscape.com)
Evaluation of testicular1
- The American Institute of Ultrasound in Medicine has published guidelines (in association with the American College of Radiology, Society for Pediatric Radiology, and Society of Radiologists in Ultrasound) on the evaluation of testicular and extratesticular structures. (medscape.com)
Germ Cell Cancer2
Modality of choice1
- According to all major guidelines, ultrasonography (US) is the imaging modality of choice for the diagnosis of testicular trauma. (medscape.com)
Benign1
- An adenomatoid tumor is a benign neoplasm of mesothelial origin that can be found in both female and male genital tracts, but it is more commonly found in the male adnexa, where it is the most common benign neoplasm. (medscape.com)
Scrotal4
- Scrotal skin lymphatics are different from testicular lymphatics and drain into the inguinal nodes. (medscape.com)
- [ 5 ] Testicular ultrasonography has a wide range of applications, varying from acute scrotal pain to more chronic and nonspecific symptoms. (medscape.com)
- Typically, scrotal and testicular ultrasonography are not associated with any complications. (medscape.com)
- Although scrotal examination combined with testis tumor marker assessments is essential for optimal patient management, the possibility of a burned-out testicular tumor with normal scrotal examination should always be kept in mind. (tjtes.org)
Epithelial Neoplasms2
- The epithelial neoplasms have occurred in older dogs compared to those of other histogenic origins (mesenchymal and other origins/round cells). (bvsalud.org)
- The frequency was 48% of epithelial neoplasms, 32% of mesenchymal neoplasms, and 10% of neoplasms with other origins and round cells. (bvsalud.org)
Prognosis1
- The prognosis for dogs with treated testicular cancer is usually very good. (furrycritter.com)
Spermatic cord1
- Testicular lymphatics follow the vessels of the spermatic cord through the inguinal canal and into the retroperitoneum. (medscape.com)
Seminoma or nonseminoma1
- No consistent different risk pattern was found for seminoma or nonseminoma testicular cancer. (nih.gov)
Neoplasia1
- 6. [Bilateral and synchronic testicular neoplasia. (nih.gov)
Inguinal1
- Evaluation of palpable inguinal, intrascrotal, or testicular masses. (medscape.com)
Incidence2
- Testicular cancer incidence rate has risen globally over the past several decades, with the average increase in the incidence of testicular cancer in Croatia of 7% per annum from the year 1983 to 2007. (nih.gov)
- An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. (nih.gov)
20171
- 17. Appendix 9: Testicular seminoma and non-seminoma: eUpdate published online 29 June 2017 (www.esmo.org/Guidelines/Genitourinary-Cancers). (nih.gov)
Leydig1
- This results in hypoplasia or absence of Leydig cells, testicular atrophy, and lower than normal androgen levels. (wikipedia.org)
Malignancy1
- Background Testicular cancer is a rare malignancy worldwide, especially among Asians. (usm.my)
Cancers2
- Treatment with radiation is linked to some second cancers after testicular cancer. (cancer.org)
- Malignant testicular neoplasms constitute about 1% of all cancers in males. (ecancer.org)
Adenocarcinoma2
- 14. Coexistence of 2 malignant urogenital neoplasms: a testicular seminoma and adenocarcinoma of the prostate gland in a patient 1 year after kidney transplantation. (nih.gov)
- The neoplasms most frequently observed, in decreasing order of frequency, were: adenocarcinoma (9/50), squamous cell carcinoma (9/50), transmissible venereal tumor (5/50), osteosarcoma (5/50), chondrosarcoma (4/50), and undifferentiated sarcoma (4/50). (bvsalud.org)
TGCT1
- Overall, the CGH analyses confirmed gains and losses of certain chromosomal regions in TGCT as observed by karyotyping, and thus support their role in the development of these neoplasms. (prinsesmaximacentrum.nl)
Left rena1
- The right testicular vein drains into the inferior vena cava and the left testicular vein drains into the left renal vein. (freezingblue.com)
Teratomas1
- Here, using the 129.MOLF-Chr19 mouse model of testicular teratomas and a NANOS2 reporter allele, we report that the developmental phenotypes required for tumorigenesis, including failure to enter mitotic arrest, retention of pluripotency and delayed sex-specific differentiation, were exclusive to a subpopulation of germ cells failing to express NANOS2. (nih.gov)
Cancer survivors2
- The most common cancer seen in testicular cancer survivors is a second testicular cancer. (cancer.org)
- Compared with most men in the general population, testicular cancer survivors are up to twice as likely to develop a new cancer outside the testicle. (cancer.org)
Diagnosis1
- Time to correct diagnosis from first visit to a doctor was significantly longer in those with back pain than in those with testicular symptoms. (ox.ac.uk)
Intrascrotal1
- MRI identified 3 intraparenchymal hematomas, 1 intrascrotal cavernous body rupture, 1 testicular abscess with intrascrotal fistula, 2 testicular infarctions, and 15 neoplasms. (medscape.com)
Histological2
- This study aimed to quantify nasosinusal neoplasms diagnosed in dogs in 20 years (2000-2019) and characterize the main clinical, macroscopic, and histological aspects of these neoplasms. (bvsalud.org)
- Through this study, it was possible to establish the frequency of these neoplasms in 20 years and their clinical, macroscopic, and histological characteristics. (bvsalud.org)
Symptoms1
- What are the symptoms of testicular cancer? (medlineplus.gov)
Adult1
- Testicular ultrasonography is a useful noninvasive tool in both adult and pediatric patient groups. (medscape.com)
Ultrasonography2
- In the clinical setting of testicular torsion , ultrasonography should not delay manual or surgical reduction. (medscape.com)
- [ 10 ] In animal studies of acute testicular ischemia, pulse-wave spectral Doppler ultrasonography has been shown to assess perfusion better than conventional color flow Doppler or power Doppler methods. (medscape.com)
Radiation therapy1
- In recent years, radiation therapy for testicular cancer has changed. (cancer.org)
Ultrasound3
- Dell'atti reported a case diagnosed with testicular ultrasound. (medscape.com)
- Ultrasound may confirm or imply testicular rupture, which should prompt exploration and attempt at repair. (medscape.com)
- 29] In the study, Doppler ultrasound revealed an inflammatory process in 277 patients, testicular trauma in 112, funicular torsion or torsion of the vestigial remnant in 44, and testicular neoplasm findings in 35. (medscape.com)
Testes1
- 10] Testicular rupture is a urologic emergency, and more than 80% of ruptured testes can be saved if surgery is performed within 72 hours. (medscape.com)