A disease of the scalp that may affect the glabrous skin and the nails and is recognized by the concave sulfur-yellow crusts that form around loose, wiry hairs. Atrophy ensues, leaving a smooth, glossy, thin, paper-white patch. This type of disease is rare in the United States and more frequently seen in the Middle East, Africa, Southeastern Europe, and other countries bordering the Mediterranean Sea. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p319)
Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.
Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.
Ringworm of the scalp and associated hair mainly caused by species of MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON, which may occasionally involve the eyebrows and eyelashes.
A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions, and is caused by Pityrosporon orbiculare. (Dorland, 27th ed)
A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair.
A fungal genus which grows in the epidermis and is the cause of TINEA.
An antifungal agent used in the treatment of TINEA infections.

Tinea capitis favosa due to Trichophyton schoenleinii. (1/3)

A case of a tinea capitis caused by Trichophyton schoenleinii is presented. It involves a 6-year old Tunisian boy that had presented with diffuse scaling of the scalp misdiagnosed as psoriasis and was treated unsuccessfully with keratolytic shampoos for two years. Tinea favosa due to Trichophyton schoenleinii was confirmed by mycological examination. He was successfully treated with griseofulvin for 6 weeks and topical application of imidazole. Trichophyton schoenleinii is an important anthropophilic dermatophyte that causes tinea favosa. It is transmitted by contagion between humans and is currently endemic in Africa. Ringworm is still frequent in Tunisia, but favus is becoming exceptional due to improvements in living conditions and hygiene.  (+info)

Morphology of griseofulvin-resistant isolates of Mongolian variant of Trichophyton schoenleini. (2/3)

Clinical, experimental and electronmicroscopic observations, and computer-enhanced images were made on 5 patients with tinea favosa resistant to griseofulvin. The pathologic fungus was identified as the Mongolian variant of Trichophyton schoenleini. The results of physical examinations, routine tests of blood, urine and stool, liver and immunologic function examinations were normal in all of the 5 patients. Under scanning electron microscopy, the surface of the spore showed pineapple-like form, the cluster of the acrogenous spores presented flower shape, and the antler-like hyphae appeared twisted in the culture. They were observed by transmission electron microscope and the images were processed by microcomputer. It was found that the cell walls of the fungi consisted of 8 layers, among which the inner layer was loose and contained cytoplasm. It was also found that all structures within the cytoplasm possessed a 1-3 layer intact envelope and there was chromatin in the nucleus. These may be contributing factors in the development of resistance to griseofulvin. This multiple-layered thick cell wall may act as a barrier responsible for the impermeability of the cell of fungi to griseofulvin.  (+info)

Experimental investigations into the therapeutic effect of griseogulvin in favus caused by Trichophyton schoenleinii. (3/3)

Experimental investigations have been carried out in 32 children on the therapeutic effect of griseofulvin in favus caused by Trichophyton schoenleinii and to determine the optimal treatment schedule.It was found that, while daily doses of 3.12 mg, 6.25 mg or 12.50 mg griseofulvin per kg of body-weight did bring about a measurable degree of inhibition of the fungal hyphae in infected hairs, a dose of 25 mg/kg daily for some 28 days was required to effect complete cure. The advantages of greater daily doses (50 mg/kg) were not sufficiently pronounced to justify the extra cost involved. Administration of doses under 50 mg/kg on alternate days is unsatisfactory, as it allows for the re-establishment of the hyphae in newly formed keratin.Another favourable schedule is the administration of 50 mg/kg daily for five days, thus setting up a stable and impenetrable griseofulvin barrier, followed for about 28 days by daily doses of 6.25 mg/kg that would otherwise be subtherapeutic but in this case prevent the reintroduction of infection from extrapilar fungi.  (+info)

Tinea favosa, also known as "black dot ringworm," is a chronic and severe form of tinea capitis (ringworm of the scalp). It is caused by the fungus Trichophyton schoenleinii. The name "black dot" refers to the appearance of hair shafts that become broken off at the skin surface, leaving small black dots on the scalp.

The infection often affects children and can cause scaling, alopecia (hair loss), and formation of kerion (a severely inflamed and pustular lesion). The condition is highly contagious and can spread through contact with infected individuals or contaminated objects such as combs, brushes, hats, and towels.

Tinea favosa can be challenging to treat due to its chronic nature and the development of extensive scarring and permanent hair loss if left untreated. Treatment typically involves oral antifungal medications for an extended period, along with proper hygiene measures to prevent the spread of infection.

Tinea is a common fungal infection of the skin, also known as ringworm. It's called ringworm because of its characteristic red, circular, and often scaly rash with raised edges that can resemble a worm's shape. However, it has nothing to do with any kind of actual worm.

The fungi responsible for tinea infections belong to the genus Trichophyton, Microsporum, or Epidermophyton. These fungi thrive in warm, damp environments and can be contracted from infected people, animals, or contaminated soil. Common types of tinea infections include athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm of the scalp (tinea capitis).

Treatment for tinea typically involves antifungal medications, either topical or oral, depending on the location and severity of the infection. Proper hygiene and avoiding sharing personal items can help prevent the spread of this contagious condition.

Tinea Pedis, also known as athlete's foot, is a fungal infection that affects the skin on the feet, particularly between the toes. The causative agents are dermatophytes, which thrive in warm and damp environments. Common symptoms include itching, burning, cracked, blistered, or scaly skin, and sometimes painful peeling or cracking of the skin. It is contagious and can spread to other parts of the body or to other people through direct contact or via contaminated surfaces. Proper hygiene, keeping the feet dry, and using antifungal medications are common methods of preventing and treating this condition.

Tinea capitis is a dermatophyte infection, primarily affecting the scalp and hair. It is commonly known as "ringworm of the scalp." The term "ringworm" is a misnomer because it has nothing to do with worms; instead, it refers to the ring-like appearance of the rash caused by these fungi.

The infection is more prevalent in children than adults and can spread through direct contact with an infected person or animal (like pets), or via contaminated objects such as combs, brushes, hats, etc. The causative agents are typically mold-like fungi called dermatophytes, which belong to the genera Microsporum or Trichophyton.

Symptoms of tinea capitis include itchiness, scaling, hair loss (in patches), and the presence of black dots on the scalp where broken hairs remain. In some cases, inflammation and pustules may occur. Diagnosis is usually confirmed through microscopic examination of hair or scale samples, and sometimes by culture.

Treatment typically involves oral antifungal medications like griseofulvin, terbinafine, itraconazole, or fluconazole for several weeks to ensure complete eradication of the fungus. Topical antifungals are often used in conjunction with oral therapy. Good hygiene practices and avoiding sharing personal items can help prevent transmission.

Tinea versicolor is a superficial fungal infection of the skin, caused by the pathogen Malassezia furfur (previously known as Pityrosporum ovale). It is characterized by the appearance of multiple round or oval patches that are hypopigmented (lighter than the surrounding skin) or hyperpigmented (darker than the surrounding skin), scaly, and can be pruritic (itchy). The lesions typically appear on the trunk and proximal extremities, often in a symmetrical pattern. Tinea versicolor is more common in warm, humid climates and in individuals with oily skin or weakened immune systems. It is usually diagnosed based on the clinical presentation and can be confirmed by microscopic examination of skin scrapings or fungal cultures. Treatment typically involves topical antifungal medications, such as clotrimazole, miconazole, or selenium sulfide, but oral medication may be necessary for severe or widespread infections.

Trichophyton is a genus of fungi that are primarily responsible for causing various superficial and cutaneous infections in humans and animals. These infections, known as dermatophytoses or ringworm, typically involve the skin, hair, and nails. Some common examples of diseases caused by Trichophyton species include athlete's foot (T. rubrum), jock itch (T. mentagrophytes), and scalp ringworm (T. tonsurans).

The fungi in the Trichophyton genus are called keratinophilic, meaning they have a preference for keratin, a protein found in high concentrations in skin, hair, and nails. This characteristic allows them to thrive in these environments and cause infection. The specific species of Trichophyton involved in an infection will determine the clinical presentation and severity of the disease.

In summary, Trichophyton is a medical term referring to a group of fungi that can cause various skin, hair, and nail infections in humans and animals.

'Epidermophyton' is a genus of fungi that can cause skin and nail infections in humans. These types of infections are known as dermatophytoses or ringworm infections. The most common species that infect humans is Epidermophyton floccosum, which tends to cause infections of the feet (athlete's foot), nails, and groin (jock itch).

Epidermophyton fungi thrive on keratin, a protein found in skin, hair, and nails. They invade the dead outer layers of the skin or nails, causing inflammation, itching, scaling, and other symptoms. The infections can be spread through direct contact with an infected person or contaminated objects like towels, shoes, or floors.

To diagnose an Epidermophyton infection, a healthcare professional may collect a sample from the affected area and examine it under a microscope for the presence of fungal elements. The diagnosis can also be confirmed through culture methods, where the sample is grown on specialized media to identify the specific fungal species.

Treatment for Epidermophyton infections typically involves topical or oral antifungal medications, depending on the severity and location of the infection. Preventive measures such as keeping the skin clean and dry, avoiding sharing personal items, and wearing breathable footwear can help reduce the risk of contracting and spreading these types of infections.

Griseofulvin is an antifungal medication used to treat various fungal infections, including those affecting the skin, hair, and nails. It works by inhibiting the growth of fungi, particularly dermatophytes, which cause these infections. Griseofulvin can be obtained through a prescription and is available in oral (by mouth) and topical (on the skin) forms.

The primary mechanism of action for griseofulvin involves binding to tubulin, a protein necessary for fungal cell division. This interaction disrupts the formation of microtubules, which are crucial for the fungal cell's structural integrity and growth. As a result, the fungi cannot grow and multiply, allowing the infected tissue to heal and the infection to resolve.

Common side effects associated with griseofulvin use include gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea), headache, dizziness, and skin rashes. It is essential to follow the prescribing physician's instructions carefully when taking griseofulvin, as improper usage may lead to reduced effectiveness or increased risk of side effects.

It is important to note that griseofulvin has limited use in modern medicine due to the development of newer and more effective antifungal agents. However, it remains a valuable option for specific fungal infections, particularly those resistant to other treatments.

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