A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in children. It is characterized by the multiple small reddish-brown pigmented pruritic macules and papules.
Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Infection with roundworms of the genus ANISAKIS. Human infection results from the consumption of fish harboring roundworm larvae. The worms may cause acute NAUSEA; VOMITING; or penetrate into the wall of the DIGESTIVE TRACT where they give rise to EOSINOPHILIC GRANULOMA in the STOMACH; INTESTINES; or the OMENTUM.
An absence of warmth or heat or a temperature notably below an accustomed norm.
A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

Repeated hand urticaria due to contact with fishfood. (1/402)

BACKGROUND: The etiology of urticaria is often difficult to determine. However, in case of repeated circumstance-connected urticaria, the reason may be easily clarifyable. CASE: A 51-year-old healthy woman repeatedly experienced occupational hand urticaria when handling fish food. An unexpected reason for the urticaria was found in that the fishfood contained histamine as a "contaminant". CONCLUSIONS: In fishfood batches, biological degradation can produce histamine and possibly other toxic substances that can lead to occupational health problems.  (+info)

Genetic linkage of the Muckle-Wells syndrome to chromosome 1q44. (2/402)

The Muckle-Wells syndrome (MWS) is a hereditary inflammatory disorder characterized by acute febrile inflammatory episodes comprising abdominal pain, arthritis, and urticaria. Progressive nerve deafness develops subsequently, and, after several years, the disease is complicated by multiorgan AA-type amyloidosis (i.e., amyloidosis derived from the inflammatory serum amyloid-associated protein) (MIM 191900) with renal involvement and end-stage renal failure. The mode of inheritance is autosomal dominant, but some sporadic cases have also been described. No specific laboratory findings have been reported. The genetic basis of MWS is unknown. Using a genomewide search strategy in three families, we identified the locus responsible for MWS, at chromosome 1q44. Our results indicate that the gene is located within a 13.9-cM region between markers D1S2811 and D1S2882, with a maximum two-point LOD score of 4. 66 (recombination fraction.00) at D1S2836 when full penetrance is assumed. Further identification of the specific gene that is responsible for MWS will therefore provide the first biological element for characterizing MWS, other than doing so on the basis of its variable clinical expression.  (+info)

Acquired lipoprotein lipase deficiency associated with chronic urticaria. A new etiology for type I hyperlipoproteinemia. (3/402)

Type I hyperlipoproteinemia (type I HLP) is a rare disorder of lipid metabolism characterized by fasting chylomicronemia and reduced postheparin plasma lipoprotein lipase (LPL) activity. Most cases of type I HLP are due to genetic defects in the LPL gene or in its activator, the apolipoprotein CII gene. Several cases of acquired type I HLP have also been described in the course of autoimmune diseases due to the presence of circulating inhibitors of LPL. Here we report a case of type I HLP due to a transient defect of LPL activity during puberty associated with chronic idiopathic urticaria (CIU). The absence of any circulating LPL inhibitor in plasma during the disease was demonstrated. The LPL genotype showed that the patient was heterozygous for the D9N variant. This mutation, previously described, can explain only minor defects in the LPL activity. The presence of HLP just after the onset of CIU, and the elevation of the LPL activity with remission of the HLP when the patient recovered from CIU, indicate that type I HLP was caused by CIU. In summary, we report a new etiology for type I HLP - a transient decrease in LPL activity associated with CIU and with absence of circulating inhibitors. This is the first description of this association, which suggests a new mechanism for type I HLP.  (+info)

Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans. (4/402)

Bradykinin is a nonapeptide that contributes to the cardioprotective effects of angiotensin-converting enzyme (ACE) inhibitors. During ACE inhibition, an increased proportion of bradykinin is degraded through non-ACE pathways. Studies in animals suggest that aminopeptidase P (EC 3.4.11.9) may contribute to the metabolism of bradykinin. The purpose of the present study was to determine the contribution of aminopeptidase P to the degradation of bradykinin in humans in the presence and absence of ACE inhibition. To do this, we measured the wheal response to intradermal injection of bradykinin (0, 1, or 10 nicrog) in the presence or absence of intradermal administration of the specific aminopeptidase P inhibitor apstatin (5 or 10 microg) and oral administration of the ACE inhibitor quinapril (10 mg) in six healthy subjects. Both bradykinin (ANOVA; F = 101.18, P <.001) and apstatin alone (F = 7.01, P =.049) caused a wheal of dose-dependent size. There was no significant interaction between apstatin and bradykinin (F = 4.94, P =.175). Pretreatment with 10 mg of quinapril significantly shifted the dose-response curve for bradykinin to the left (effect of quinapril; F = 77.96, P <.001) and there was significant interaction between quinapril and bradykinin (F = 7.82, P =.041). The effect of quinapril was significantly potentiated by coinjection of 10 microg of apstatin (effect of apstatin; F = 21.60, P =.006), such that there was significant interactive effect of quinapril and apstatin (F = 20.83, P =.006) on the wheal response to bradykinin. Collectively, these data suggest that aminopeptidase P plays a minor role in the degradation of bradykinin in human skin in the absence of ACE inhibition but contributes significantly to the degradation of bradykinin in the presence of ACE inhibition.  (+info)

Pharmacodynamic interaction of eltanolone and alfentanil during lower abdominal surgery in female patients. (5/402)

We have studied the influence of eltanolone on intraoperative alfentanil requirements in 18 female patients undergoing lower abdominal surgery receiving target-controlled infusions of eltanolone and alfentanil. While target concentrations of eltanolone were maintained constant, target concentrations of alfentanil changed in response to the presence or absence of responses. With serum eltanolone concentrations increasing from 500 to 2000 ng ml-1, the EC50 of alfentanil for suppression of responses to surgical stimulation decreased from 233 to 9 ng ml-1. The findings suggest that the interaction between eltanolone and alfentanil is synergistic.  (+info)

Additive-induced urticaria: experience with monosodium glutamate (MSG). (6/402)

In patients with chronic urticaria, the incidence of reactions to any additives, including monosodium glutamate (MSG), is unknown. Although many studies have investigated the association of additives and urticaria, most have been poorly designed. This study sought to determine the prevalence of reactions to additives, including MSG, in patients with chronic urticaria using a rigorous protocol. We studied 65 subjects (44 women, 21 men; ages 14-67). All had urticaria for >6 wk without discernible etiology. Subjects with active urticaria were studied while they were taking the lowest effective dose of antihistamine. Screening challenges to the 11 additives most commonly associated with exacerbations of chronic idiopathic urticaria were performed in a single-blind fashion. The dose of MSG given was 2500 mg. Skin scores were obtained to determine a positive reaction in an objective manner. Subjects with a positive screening challenge were rechallenged (at least 2 wk later) with a double-blind, placebo-controlled protocol as in-patients in our General Clinical Research Center. Two subjects had positive single-blind, placebo-controlled challenges, but neither had a positive double-blind, placebo-controlled challenge. We conclude, with 95% confidence, that MSG is an unusual (<3% at most) exacerbant of chronic idiopathic urticaria.  (+info)

Identification of a locus on chromosome 1q44 for familial cold urticaria. (7/402)

Familial cold urticaria (FCU) is a rare autosomal dominant inflammatory disorder characterized by intermittent episodes of rash with fever, arthralgias, conjunctivitis, and leukocytosis. These symptoms develop after generalized exposure to cold. Some individuals with FCU also develop late-onset reactive renal amyloidosis, which is consistent with Muckle-Wells syndrome. By analyzing individuals with FCU from five families, we identified linkage to chromosome 1q44. Two-point linkage analysis revealed a maximum LOD score (Zmax) of 8.13 (recombination fraction 0) for marker D1S2836; multipoint linkage analysis identified a Zmax of 10. 92 in the same region; and haplotype analysis defined a 10.5-cM region between markers D1S423 and D1S2682. Muckle-Wells syndrome was recently linked to chromosome 1q44, which suggests that the two disorders may be linked to the same locus.  (+info)

Medical surveillance of allergy in laboratory animal handlers. (8/402)

Allergic disease is a serious occupational health concern for individuals who have contact with laboratory animals. The principal respiratory symptoms include allergic rhinitis, conjunctivitis, and asthma. Urticaria (" hives") is the most common skin manifestation. The overall prevalence of allergic disease among laboratory animal handlers is about 23%, and respiratory allergy is much more common than skin allergy. Various studies have found annual incidence rates ranging from 2% to 12%. Prevention of animal allergy depends on control of allergenic material in the work environment. Personal protective equipment such as air filtering respirators should be used in addition to the other exposure control technologies where conditions require. Pre-placement evaluation and periodic medical surveillance of workers are important pieces of the overall occupational health program. The emphasis of these medical evaluations should be on counseling and early disease detection. The article gives recommendations for the content of the medical evaluations.  (+info)

Urticaria, also known as hives, is an allergic reaction that appears on the skin. It is characterized by the rapid appearance of swollen, pale red bumps or plaques (wheals) on the skin, which are often accompanied by itching, stinging, or burning sensations. These wheals can vary in size and shape, and they may change location and appear in different places over a period of hours or days. Urticaria is usually caused by an allergic reaction to food, medication, or other substances, but it can also be triggered by physical factors such as heat, cold, pressure, or exercise. The condition is generally harmless, but severe cases of urticaria may indicate a more serious underlying medical issue and should be evaluated by a healthcare professional.

Urticaria pigmentosa is a rare mast cell disorder, characterized by the development of brownish-red, raised lesions (maculopapules) on the skin. These lesions are often found on the trunk and proximal extremities, but can occur anywhere on the body. They are typically asymptomatic, but may become itchy or even painful when subjected to friction, heat, or emotional stress. In some cases, these lesions may also release histamine, leading to symptoms such as flushing, headache, and hypotension. Urticaria pigmentosa is more common in children than adults, and typically resolves on its own over time. However, in some cases it can persist into adulthood or even progress to systemic mastocytosis, a more severe form of the disorder that can affect internal organs.

Angioedema is a medical condition characterized by rapid swelling of the skin, mucous membranes, and submucosal tissues. The swelling typically occurs in the face, lips, tongue, larynx, and extremities, and can also affect the gastrointestinal tract. Angioedema can be caused by a variety of factors, including allergic reactions, hereditary genetic mutations, and certain medications.

In medical terms, angioedema is defined as a self-limiting episode of localized edema in the deep dermis, subcutaneous tissue, or mucous membranes, characterized by well-circumscribed, nonpitting, nondependent swelling. The swelling can occur suddenly and may persist for up to 72 hours. In severe cases, angioedema can cause airway obstruction and be life-threatening if not treated promptly.

Angioedema can be classified into two main types: allergic or non-allergic. Allergic angioedema is caused by an immune response to an allergen, such as food, medication, or insect venom. Non-allergic angioedema can be further divided into several subtypes, including hereditary angioedema (HA), acquired angioedema (AAE), and drug-induced angioedema.

Hereditary angioedema is a rare genetic disorder caused by mutations in the C1 inhibitor gene, leading to uncontrolled activation of the complement system and increased production of bradykinin, a potent vasodilator. Acquired angioedema is similar to hereditary angioedema but occurs later in life and is associated with underlying medical conditions such as lymphoproliferative disorders or autoimmune diseases. Drug-induced angioedema can be caused by a variety of medications, including ACE inhibitors, angiotensin receptor blockers (ARBs), and nonsteroidal anti-inflammatory drugs (NSAIDs).

The diagnosis of angioedema is typically based on clinical presentation, medical history, and laboratory tests. Treatment depends on the underlying cause of the condition but may include antihistamines, corticosteroids, epinephrine, and medications that target the complement system or bradykinin pathway. In severe cases, hospitalization and intensive care may be necessary to manage airway obstruction and other complications.

Histamine H1 antagonists, non-sedating, also known as second-generation antihistamines, are medications that block the action of histamine at the H1 receptor without causing significant sedation. Histamine is a chemical mediator released by mast cells and basophils in response to an allergen, leading to allergic symptoms such as itching, sneezing, runny nose, and hives.

The non-sedating antihistamines have a higher affinity for the H1 receptor and are less lipophilic than first-generation antihistamines, which results in less penetration of the blood-brain barrier and reduced sedative effects. Examples of non-sedating antihistamines include cetirizine, levocetirizine, loratadine, desloratadine, fexofenadine, and rupatadine. These medications are commonly used to treat allergic rhinitis, urticaria, and angioedema.

Skin tests are medical diagnostic procedures that involve the application of a small amount of a substance to the skin, usually through a scratch, prick, or injection, to determine if the body has an allergic reaction to it. The most common type of skin test is the patch test, which involves applying a patch containing a small amount of the suspected allergen to the skin and observing the area for signs of a reaction, such as redness, swelling, or itching, over a period of several days. Another type of skin test is the intradermal test, in which a small amount of the substance is injected just beneath the surface of the skin. Skin tests are used to help diagnose allergies, including those to pollen, mold, pets, and foods, as well as to identify sensitivities to medications, chemicals, and other substances.

Histamine H1 antagonists, also known as H1 blockers or antihistamines, are a class of medications that work by blocking the action of histamine at the H1 receptor. Histamine is a chemical mediator released by mast cells and basophils in response to an allergic reaction or injury. It causes various symptoms such as itching, sneezing, runny nose, and wheal and flare reactions (hives).

H1 antagonists prevent the binding of histamine to its receptor, thereby alleviating these symptoms. They are commonly used to treat allergic conditions such as hay fever, hives, and eczema, as well as motion sickness and insomnia. Examples of H1 antagonists include diphenhydramine (Benadryl), loratadine (Claritin), cetirizine (Zyrtec), and doxylamine (Unisom).

Drug hypersensitivity is an abnormal immune response to a medication or its metabolites. It is a type of adverse drug reaction that occurs in susceptible individuals, characterized by the activation of the immune system leading to inflammation and tissue damage. This reaction can range from mild symptoms such as skin rashes, hives, and itching to more severe reactions like anaphylaxis, which can be life-threatening.

Drug hypersensitivity reactions can be classified into two main types: immediate (or IgE-mediated) and delayed (or non-IgE-mediated). Immediate reactions occur within minutes to a few hours after taking the medication and are mediated by the release of histamine and other inflammatory mediators from mast cells and basophils. Delayed reactions, on the other hand, can take several days to develop and are caused by T-cell activation and subsequent cytokine release.

Common drugs that can cause hypersensitivity reactions include antibiotics (such as penicillins and sulfonamides), nonsteroidal anti-inflammatory drugs (NSAIDs), monoclonal antibodies, and chemotherapeutic agents. It is important to note that previous exposure to a medication does not always guarantee the development of hypersensitivity reactions, as they can also occur after the first administration in some cases.

The diagnosis of drug hypersensitivity involves a thorough medical history, physical examination, and sometimes skin or laboratory tests. Treatment typically includes avoiding the offending medication and managing symptoms with antihistamines, corticosteroids, or other medications as needed. In severe cases, emergency medical care may be required to treat anaphylaxis or other life-threatening reactions.

A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.

Anaphylaxis is a severe, life-threatening systemic allergic reaction that occurs suddenly after exposure to an allergen (a substance that triggers an allergic reaction) to which the person has previously been sensitized. The symptoms of anaphylaxis include rapid onset of symptoms such as itching, hives, swelling of the throat and tongue, difficulty breathing, wheezing, cough, chest tightness, rapid heartbeat, hypotension (low blood pressure), shock, and in severe cases, loss of consciousness and death. Anaphylaxis is a medical emergency that requires immediate treatment with epinephrine (adrenaline) and other supportive measures to stabilize the patient's condition.

Histamine antagonists, also known as histamine blockers or H1-blockers, are a class of medications that work by blocking the action of histamine, a substance in the body that is released during an allergic reaction. Histamine causes many of the symptoms of an allergic response, such as itching, sneezing, runny nose, and hives. By blocking the effects of histamine, these medications can help to relieve or prevent allergy symptoms.

Histamine antagonists are often used to treat conditions such as hay fever, hives, and other allergic reactions. They may also be used to treat stomach ulcers caused by excessive production of stomach acid. Some examples of histamine antagonists include diphenhydramine (Benadryl), loratadine (Claritin), and famotidine (Pepcid).

It's important to note that while histamine antagonists can be effective at relieving allergy symptoms, they do not cure allergies or prevent the release of histamine. They simply block its effects. It's also worth noting that these medications can have side effects, such as drowsiness, dry mouth, and dizziness, so it's important to follow your healthcare provider's instructions carefully when taking them.

Anti-allergic agents, also known as antihistamines, are a class of medications used to treat allergies. They work by blocking the action of histamine, a substance in the body that is released during an allergic reaction and causes symptoms such as itching, sneezing, runny nose, and watery eyes.

There are two main types of antihistamines: first-generation and second-generation. First-generation antihistamines, such as diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton), can cause drowsiness and other side effects, such as dry mouth and blurred vision. They are typically used for the treatment of short-term symptoms, such as those caused by seasonal allergies or a mild reaction to an insect bite.

Second-generation antihistamines, such as loratadine (Claritin) and cetirizine (Zyrtec), are less likely to cause drowsiness and other side effects. They are often used for the long-term treatment of chronic allergies, such as those caused by dust mites or pet dander.

In addition to their use in treating allergies, antihistamines may also be used to treat symptoms of motion sickness, insomnia, and anxiety. It is important to follow the instructions on the label when taking antihistamines and to talk to a healthcare provider if you have any questions or concerns about using these medications.

Food hypersensitivity is an umbrella term that encompasses both immunologic and non-immunologic adverse reactions to food. It is also known as "food allergy" or "food intolerance." Food hypersensitivity occurs when the body's immune system or digestive system reacts negatively to a particular food or food component.

Immunologic food hypersensitivity, commonly referred to as a food allergy, involves an immune response mediated by immunoglobulin E (IgE) antibodies. Upon ingestion of the offending food, IgE antibodies bind to the food antigens and trigger the release of histamine and other chemical mediators from mast cells and basophils, leading to symptoms such as hives, swelling, itching, difficulty breathing, or anaphylaxis.

Non-immunologic food hypersensitivity, on the other hand, does not involve the immune system. Instead, it is caused by various mechanisms, including enzyme deficiencies, pharmacological reactions, and metabolic disorders. Examples of non-immunologic food hypersensitivities include lactose intolerance, gluten sensitivity, and histamine intolerance.

It's important to note that the term "food hypersensitivity" is often used interchangeably with "food allergy," but it has a broader definition that includes both immunologic and non-immunologic reactions.

Cetirizine is an antihistamine medication that is used to relieve symptoms of allergies, such as hay fever, hives, and other allergic skin conditions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Cetirizine is available over-the-counter and by prescription in various forms, including tablets, chewable tablets, and syrup.

The medical definition of Cetirizine is:

Cetirizine hydrochloride: A second-generation antihistamine with selective peripheral H1 receptor antagonist activity. A potent and long-acting inhibitor of the early and late phases of the allergic reaction, it exhibits anti-inflammatory properties and has a more favorable side effect profile than many other antihistamines. It is used in the management of allergic rhinitis, chronic urticaria, and angioedema.

Immunoglobulin E (IgE) is a type of antibody that plays a key role in the immune response to parasitic infections and allergies. It is produced by B cells in response to stimulation by antigens, such as pollen, pet dander, or certain foods. Once produced, IgE binds to receptors on the surface of mast cells and basophils, which are immune cells found in tissues and blood respectively. When an individual with IgE antibodies encounters the allergen again, the cross-linking of IgE molecules bound to the FcεRI receptor triggers the release of mediators such as histamine, leukotrienes, prostaglandins, and various cytokines from these cells. These mediators cause the symptoms of an allergic reaction, such as itching, swelling, and redness. IgE also plays a role in protecting against certain parasitic infections by activating eosinophils, which can kill the parasites.

In summary, Immunoglobulin E (IgE) is a type of antibody that plays a crucial role in the immune response to allergens and parasitic infections, it binds to receptors on the surface of mast cells and basophils, when an individual with IgE antibodies encounters the allergen again, it triggers the release of mediators from these cells causing the symptoms of an allergic reaction.

Loratadine is an antihistamine medication that is commonly used to relieve symptoms of allergies, such as hay fever, hives, and other skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Loratadine is available over-the-counter in various forms, including tablets, capsules, and syrup.

The medical definition of loratadine is: "A second-generation antihistamine used for the symptomatic treatment of allergies, including hay fever, hives, and other skin reactions. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms."

It's important to note that while loratadine is generally considered safe, it can cause side effects such as dizziness, dry mouth, and headache. If you have any concerns about taking loratadine or experience severe side effects, you should speak with your healthcare provider.

Anisakiasis is a gastrointestinal disease caused by the accidental consumption and infection with larvae of nematode parasites belonging to the genus Anisakis. The life cycle of these parasites typically involves marine animals such as fish and squid, which serve as intermediate or paratenic hosts. Human infections usually occur when people eat raw or undercooked seafood that contains infective larvae.

After ingestion, the larvae can penetrate the gastrointestinal mucosa, causing an inflammatory reaction and potentially leading to symptoms such as abdominal pain, nausea, vomiting, diarrhea, or fever. In some cases, the larvae may invade deeper tissues, resulting in more severe complications like allergic reactions, intestinal obstruction, or perforation.

Diagnosis of anisakiasis is often based on clinical presentation, epidemiological data, and detection of parasite larvae in biopsy samples, stool specimens, or vomitus. Treatment typically involves endoscopic removal of the larvae, supportive care for symptoms, and sometimes anti-parasitic medication. Preventive measures include thoroughly cooking seafood, freezing it at temperatures below -20°C (-4°F) for at least 7 days, or practicing proper hygiene during food preparation to minimize the risk of infection.

"Cold temperature" is a relative term and its definition can vary depending on the context. In general, it refers to temperatures that are lower than those normally experienced or preferred by humans and other warm-blooded animals. In a medical context, cold temperature is often defined as an environmental temperature that is below 16°C (60.8°F).

Exposure to cold temperatures can have various physiological effects on the human body, such as vasoconstriction of blood vessels near the skin surface, increased heart rate and metabolic rate, and shivering, which helps to generate heat and maintain body temperature. Prolonged exposure to extreme cold temperatures can lead to hypothermia, a potentially life-threatening condition characterized by a drop in core body temperature below 35°C (95°F).

It's worth noting that some people may have different sensitivities to cold temperatures due to factors such as age, health status, and certain medical conditions. For example, older adults, young children, and individuals with circulatory or neurological disorders may be more susceptible to the effects of cold temperatures.

Cyproheptadine is an antihistamine and anticholinergic medication that is primarily used to treat symptoms of allergies, such as runny nose, sneezing, and itching. It works by blocking the action of histamine, a substance in the body that causes allergic reactions.

Cyproheptadine also has other uses, including the treatment of migraines and cluster headaches, appetite stimulation in people with certain medical conditions, and as a sedative in some cases. It is available in various forms, such as tablets, capsules, and syrup.

Like all medications, cyproheptadine can have side effects, including drowsiness, dry mouth, dizziness, and blurred vision. It is important to follow the dosage instructions carefully and talk to a healthcare provider if you experience any bothersome or persistent side effects.

... is a skin disorder and one of the most common types of urticaria, affecting 2-5% of the population. ... The first outbreak of urticaria can lead to other reactions on body parts not directly stimulated, scraped, or scratched. In a ... Kontou-Fili, K.; Borici-Mazi, R.; Kapp, A.; Matjevic, L.J.; Mitchel, F.B. (1997). "Physical urticaria: classification and ... These wheals are a subset of urticaria (hives), and appear within minutes, in some cases accompanied by itching. ...
Aquagenic urticaria Urticaria Skin lesion List of cutaneous conditions James, William; Berger, Timothy; Elston, Dirk (2005). ... Adrenergic urticaria is a skin condition characterized by an eruption consisting of small (1-5mm) red macules and papules with ... ISBN 978-1-4160-2999-1. Hogan, Sara R.; Mandrell, Joshua; Eilers, David (1 April 2014). "Adrenergic urticaria: review of the ... v t e (Articles with short description, Short description matches Wikidata, Urticaria and angioedema, All stub articles, ...
Finally, cholinergic urticaria, or urticaria induced by heat, can occasionally appear to be solar urticaria because the heat ... The name "solar urticaria" was proposed in 1923. In 1928, urticaria was induced for the first time. This was carried out by ... Physical urticaria arises from physical factors in the environment, which in the case of solar urticaria is UV radiation or ... Solar urticaria accounts for less than one percent of the many documented urticaria cases. To put that into a better ...
... presents within five minutes after the skin has been exposed to heat above 43 °C (109 °F), with the exposed area ... ISBN 978-1-4160-2999-1. v t e (Articles with short description, Short description matches Wikidata, Urticaria and angioedema, ... becoming burned, stinging, and turning red, swollen, and indurated.: 155 Urticaria Skin lesion List of cutaneous conditions ...
... (essentially meaning cold hives) is a disorder in which large red welts called hives (urticaria) form on the ... Cold urticaria may be divided into the following types: Primary cold contact urticaria is a cutaneous condition characterized ... Amyloidosis Cholinergic urticaria, a similar hives reaction in response to heat Aquagenic urticaria Diascopy Erythema Goose ... Reflex cold urticaria is a cutaneous condition in which generalized cooling of the body induces widespread welting. Familial ...
... is a type of hives (urticaria) that is triggered by an increase in body temperature, such as during ... Cholinergic urticaria was first described by Duke in 1924 as "urticaria calorica". The term cholinergic is derived from the ... Cholinergic urticaria can be painful and uncomfortable and may interfere with daily activities. Cholinergic urticaria typically ... It is also sometimes called exercise-induced urticaria or heat hives. The condition is caused by an overreaction of the immune ...
... is a physical urticaria caused by pressure applied to the skin, and is characterized by the development of ... 266-7. ISBN 978-1-4160-2999-1. v t e (Articles with short description, Short description matches Wikidata, Urticaria and ... swelling and pain that usually occurs 3 to 12 hours after local pressure has been applied.: 155 Urticaria Skin lesion List of ...
... has been described after exposure to a galvanic (electrical) device used to treat hyperhidrosis.: 155 ... v t e (All stub articles, Cutaneous condition stubs, Urticaria and angioedema). ... Urticaria Skin lesion James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology ...
... delayed pressure urticaria (DPU) cholinergic urticaria (ChU) cold urticaria (CU) solar urticaria (SU) acute pressure urticaria ... This type of urticaria is uncommon and occurs in only 0.1% of the population. 20% of people with chronic urticaria report still ... Physical urticaria is known to be painful, itchy and physically unappealing; it can recur for months to years. Urticaria are ... Physical urticaria is a distinct subgroup of urticaria (hives) that are induced by an exogenous physical stimulus rather than ...
... , also known as water allergy and water urticaria, is a rare form of physical urticaria in which hives ... Once known as a separate, rare disease, aquagenic urticaria is now considered a subtype of general urticaria. The first case ... avoids confusion with cold urticaria or cholinergic urticaria. In addition, a forearm or hand can be immersed in water of ... Phototherapy Barrier cream Aquagenic pruritus Aquadynia Cholinergic urticaria Solar urticaria List of cutaneous conditions NIH ...
Urticaria Dermatographic urticaria Generalized eruption of cutaneous mastocytosis (adult type) James, William; Berger, Timothy ... Urticaria pigmentosa is characterized by excessive amounts of mast cells in the skin. Red or brown spots are often seen on the ... Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type): 616 ) is the most common ... "Urticaria pigmentosa (mastocytosis). DermNet NZ". dermnetnz.org. Archived from the original on 2004-06-04. Fairley JA, Pentland ...
... , the false crocus geometer, is a North American moth in the family Geometridae. The wings are bright ... ISBN 1-884549-21-7 Wikimedia Commons has media related to Xanthotype urticaria. v t e (Articles with short description, Short ...
... , also known as chronic autoimmune urticaria, is a type of chronic urticaria characterized by the presence ... The term "autoimmune urticaria" refers to a subset of chronic spontaneous urticaria (CSU) cases where the immune system appears ... These can include allergic reactions, other types of urticaria such as physical urticaria (triggered by physical stimuli such ... urticaria). This immunologically distinct type of urticaria is considered autoimmune because the immune system, which normally ...
... occurs by immunologic and nonimmunologic mechanisms, urticaria most commonly caused by aspirin and ... ISBN 0-7216-2921-0. v t e (Articles with short description, Short description matches Wikidata, Drug eruptions, Urticaria and ... NSAIDs.: 120 List of cutaneous conditions Localized heat contact urticaria Skin lesion Urticarial dermatoses James, William; ...
... is known as one of the more painful subsets of physical urticaria due to formed hives being deep- ... v t e (Wikipedia articles that are too technical from May 2016, All articles that are too technical, Urticaria and angioedema, ... G. A. Vena, V. D'argento, N. Cassano,. "Sequential Therapy with Nimesulide and Ketotifen in Delayed Pressure Urticaria." Acta ... "Effect of High-dose Intravenous Immunoglobulin in Delayed Pressure Urticaria." Br J Dermatol British Journal of Dermatology ...
... is a rare cutaneous disorder that occurs primarily in middle-aged men. Mucinosis List of ... ISBN 978-1-4160-2999-1. v t e (Articles with short description, Short description matches Wikidata, Urticaria and angioedema, ...
... is a cutaneous condition, one of the rarest forms of urticaria, where within minutes of ... Drug-induced urticaria List of cutaneous conditions Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). ... ISBN 978-1-4160-2999-1. v t e (Articles with short description, Short description matches Wikidata, Urticaria and angioedema, ...
Physical urticarias (requires a primary stimulation) d. Chronic autoimmune urticaria 3. Idiopathic (When mast cell ... Urticaria d. Mast cell activation syndrome (MCAS)... Recurrent idiopathic anaphylaxis presents with allergic signs and symptoms ... problems in the absence of elevated serum IgE and chronic urticaria, suggesting non-allergic mast cell activation in response ...
Cholinergic urticaria (CU) is one of the physical urticaria (hives) which is provoked during sweating events such as exercise, ... Hirschmann JV, Lawlor F, English JS, Louback JB, Winkelmann RK, Greaves MW (April 1987). "Cholinergic urticaria. A clinical and ... Sweating can trigger intense itching or cholinergic urticaria. The protein MGL_1304 secreted by mycobiota (fungi) present on ... Moore-Robinson M, Warin RP (December 1968). "Some clinical aspects of cholinergic urticaria". The British Journal of ...
A review article evaluated data from trials which detailed the efficacy of bilastine in skin models and urticaria to assess ... The clinical efficacy of bilastine in allergic rhinitis (AR) and urticaria has been assessed in 10 clinical assays in which ... Bilastine is approved in the European Union for the symptomatic treatment of allergic conjunctivitis and urticaria. It is not ... Church MK, Labeaga L (September 2017). "Bilastine: a new H1 -antihistamine with an optimal profile for updosing in urticaria". ...
itching and urticaria. joint pain (arthralgia), especially in finger and toe joints. fever, usually appears before rash. This ...
Chronic spontaneous urticaria. Dapsone is effective and safe for treatment of second-line therapy for people with chronic ... Antia C, Baquerizo K, Korman A, Alikhan A, Bernstein JA (October 2018). "Urticaria: A comprehensive review: Treatment of ... "Use of Dapsone in the Treatment of Chronic Idiopathic and Autoimmune Urticaria". JAMA Dermatol. 155 (1): 90-95. doi:10.1001/ ... chronic urticaria, special populations, and disease outcomes". J. Am. Acad. Dermatol. 79 (4): 617-633. doi:10.1016/j.jaad. ...
Urticaria (hives) may develop simultaneously.[citation needed] In severe cases, stridor of the airway occurs, with gasping or ... On giant urticaria. Edinburgh Medical Journal, 1876, 22: 513-526. Osler W (1888). "Hereditary angio-neurotic oedema". Am J Med ... There is usually no associated itch or urticaria, as it is not an allergic response. Patients with HAE can also have recurrent ... It is usually caused by allergy and occurs together with other allergic symptoms and urticaria. It can also occur as a side ...
Church, Martin K. (2021). "Antihistamines". Urticaria and Angioedema. Springer International Publishing. pp. 153-165. doi: ...
Spickett G (2014). "Urticaria and angioedema". J R Coll Physicians Edinb. 44 (1): 50-4. doi:10.4997/JRCPE.2014.112. PMID ... urticaria, angioedema, ulcerative colitis, pericarditis, temporal arteritis and Crohn's disease, Bell's palsy, multiple ... clouding of lenses and urticaria. However, their prevalence is not known. Prednisolone eye drops are contraindicated in ...
... is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria ... Dermatographic urticaria Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs". Journal of ...
Erythema and urticaria". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Elsevier. pp. 141-142. ISBN 978-0-323- ...
Wanderer AA, St Pierre JP, Ellis EF (October 1977). "Primary acquired cold urticaria. Double-blind comparative study of ... Neuritis Convulsions Euphoria Hallucinations Hysteria Faintness Allergic manifestation of rash and edema Diaphoresis Urticaria ...
James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "7. Erythema and urticaria". ...
Inflammatory skin diseases presenting with erythema, urticaria and purpura". Atlas of Dermatology: Inflammatory, Infectious and ... Erythema and urticaria". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 144. ISBN 978- ...
Dermatographic urticaria is a skin disorder and one of the most common types of urticaria, affecting 2-5% of the population. ... The first outbreak of urticaria can lead to other reactions on body parts not directly stimulated, scraped, or scratched. In a ... Kontou-Fili, K.; Borici-Mazi, R.; Kapp, A.; Matjevic, L.J.; Mitchel, F.B. (1997). "Physical urticaria: classification and ... These wheals are a subset of urticaria (hives), and appear within minutes, in some cases accompanied by itching. ...
... urticaria), swelling (angioedema), redness (erythema), and itching (pruritus) in the affected area. Explore symptoms, ... Vibratory urticaria is a condition in which exposing the skin to vibration, repetitive stretching, or friction results in ... Abajian M, Schoepke N, Altrichter S, Zuberbier T, Maurer M. Physical urticarias and cholinergic urticaria. Immunol Allergy Clin ... Vibratory urticaria can be caused by a mutation in the ADGRE2 gene. This gene provides instructions for making a protein found ...
Patients who have urticaria for more than 6 weeks are given the diagnosis of chronic urticaria. ... a subset of chronic urticaria, which presents with erythematous swelling at sites of pressure. ... Pressure urticaria is an uncommon form of physical urticaria, ... urticaria, thermal (heat or cold) urticaria, solar urticaria, ... Pressure urticaria is an uncommon form of physical urticaria, a subset of chronic urticaria, which presents with erythematous ...
Urticaria. What Are Hives?. Hives are red raised bumps or welts on the skin. Hives (or urticaria) is a common skin reaction to ...
You do not provide the time of onset of the urticaria with respect to the injection but I assume it was more than 12 hours and ... Botulinium (Botox) reaction with urticaria. Question:. Reviewed: February 24, 2020. 8/19/2015. I was asked to see a 35 y/o ... Hypersensitivity reactions, with urticaria, anaphylaxis and one fatility, have been reported and the label recommends that " ... These reactions include anaphylaxis, serum sickness, urticaria, soft tissue edema, and dyspnea. If such a reaction occurs, ...
... also known as urticaria) and angioedema, including their causes, diagnosis, treatment, and management. ... Hives, Urticaria, and Angioedema Medically Reviewed by Jabeen Begum, MD on April 17, 2023 ... Chronic urticaria and/or angioedema: Hives or swelling that lasts more than 6 weeks. The cause is usually harder to find than ... Acute urticaria and/or angioedema: With these conditions, hives or swelling lasts less than 6 weeks. The most common causes are ...
Cold urticaria can be diagnosed by placing an ice cube on the skin for five minutes. If you have cold urticaria, a raised bump ... Idiopathic cold urticaria and anaphylaxis. Pediatric Emergency Care. 2014;30:38.. *Abajian M, et al. Physical urticarias and ... In some people, cold urticaria goes away on its own after weeks or months. In others, it lasts longer. There is no cure for the ... Urticaria and angioedema. In: Fitzpatricks Color Atlas and Synopsis of Clinical Dermatology. 8th ed. New York, N.Y.: The ...
... Article Translations: (Spanish). What Are Hives?. Hives are red raised bumps or welts on the skin. Hives (or ... urticaria) is a common skin reaction to something like an allergen (a substance that causes allergies). ...
Urticaria. What Are Hives?. Hives are red raised bumps or welts on the skin. Hives (or urticaria) is a common skin reaction to ...
Papular urticaria is a common and often annoying disorder manifested by chronic or recurrent papules caused by a ... encoded search term (Papular Urticaria) and Papular Urticaria What to Read Next on Medscape ... Papular urticaria is generally regarded to be the result of a hypersensitivity or id reaction to bites from insects, [10] such ... Papular urticaria is also common in Colombia, linked with exposure to indoor fleas and poverty. [6] In Bogotá, Colombia among ...
... Arch Dermatol. 1986 Feb;122(2):138-9. ...
In case of frequent episodes of urticaria, you should consult with your doctor the advisabilit ... How to cure urticaria with supplements Vitamins for urticria There is wide evidence that some supplements are particularly ... interesting in the treatment of allergic diseases such as allergic urticaria. ... "Folk Remedies" to treat urticaria. Some home remedies might prove useful tips to reduce the unpleasant symptoms of urticaria. ...
Cold urticaria can become dangerous in rare cases, such as when hives appear all over the body after jumping into cold water. ... Cold urticaria. Our skin reacts to the cold: rosy cheeks and goose bumps are visible signs of this reaction. But low ... But the good news is that cold urticaria goes away by itself after some time, although it does take on average four to five ... People who react in such a way to a cold stimulus within five to ten minutes probably have a specific type of urticaria, known ...
Acute urticaria can be effectively treated with a non-sedating antihistamine. Background. *Urticaria is a common skin condition ... Urticaria usually appears within 1-2 hours of the exposure and disappears within 6-8 hours *Urticaria lasting days are almost ... Acute urticaria lasts for less than 6 weeks and chronic urticaria occurs most days for more than 6 weeks ... Viral infection is a common cause of urticaria in children. *Urticaria may occur both during and after an illness when the ...
Solar Urticaria and Disturbed Metabolism of Porphyrins Subject Area: Dermatology , Immunology and Allergy ... R.C. Beljaards, D.P. Bruynzeel; Solar Urticaria and Disturbed Metabolism of Porphyrins. Dermatologica 1 April 1991; 182 (4): ... We report on a case of solar urticaria with elevated protoporphyrin in the stool. No other evidence for an erythropoietic ...
ED And Urticaria - ABC Homeopathy Forum. 1 reply to 2014-02-01. ... also suffering from urticaria for 3 yrs. Plz suggest all these ... sinusitis, pnd or cold alergy, ED and urticaria. I m 31 yrs old male. I ve been suffering from the following problems since my ...
3.2 NSAID-induced urticaria/angioedema. Patients with NSAID-induced urticaria and/or angioedema (NIUA) do not have spontaneous ... 3.4 NSAID-induced recall urticaria. Recall urticaria (RU) is a rare biologic phenomenon characterized by the existence of hives ... In the case of NECD the ideal is to carry out the study in a period of remission of chronic spontaneous urticaria. If this is ... 3.5 Selective acute urticaria/angioedema and anaphylaxis. The existence of underlying diseases is common in NECD, NIUA and IPA ...
... is a monoclonal anti-IgE antibody that has been approved for the treatment of refractory chronic spontaneous urticaria (CSU) in ... The urticaria activity score (UAS) and urticaria control test (UCT) are disease measurement tools that can be used for defining ... Omalizumab in Chronic Spontaneous Urticaria. Question. For how long should we use omalizumab in chronic spontaneous urticaria? ... Omalizumab retreatment of patients with chronic idiopathic urticaria / chronic spontaneous urticaria following return of ...
Urticaria (hives) is a skin rash characterised by very itchy weals, with or without surrounding erythematous flares. In this ... Urticaria (hives) is a skin rash characterised by very itchy weals, with or without surrounding erythematous flares. In this ...
Urticaria Pigmentosa. definition. The most common form of mastocytosis. It occurs primarily in children and is characterized by ... Urticaria Pigmentosa. UMLS. Localized cutaneous mastocytosis, NOS, Urticaria Pigmentosa, Urticaria pigmentosa, NOS, Urticaria, ...
Disucssion on 5 top homeopathic remedies for hive (urticaria) treatment. Dr. Manisha Bhatia. ... The medical term for hive is urticaria. Hives are usually allergic reaction to food or medicine. These appear as raised, red, ... The medical term for hive is urticaria. Hives are usually allergic reaction to food or medicine. These appear as raised, red, ...
People with chronic urticaria may be put through unnecessary and expensive allergy testing, when the focus should be on ... Many patients with chronic urticaria spend years in misery trying to find the cause of their hives, but the long-term approach ... Allergy testing a waste of time in hives (urticaria). by 6minutes , Latest Health News, Skin & Hair ... University of Melbourne dermatologist Professor Rod Sinclair, says people with chronic urticaria may be put through unnecessary ...
Urticaria Pigmentosa: The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in ... Urticaria Pigmentosa. Subscribe to New Research on Urticaria Pigmentosa The most common form of cutaneous mastocytosis ( ... chronic urticaria and some rare, sclerosing skin diseases. ". 01/01/1985 - "Phototherapy of urticaria pigmentosa: clinical ... Drugs and Important Biological Agents (IBA) related to Urticaria Pigmentosa: 1. Adrenal Cortex Hormones (Corticosteroids)IBA 09 ...
Isaac Gerg published Chronic Spontaneous Urticaria (CSU) Following COVID-19 Vaccine: Preliminary Observations and Self-Tracking ... Chronic spontaneous urticaria (CSU, chronic idiopathic urticaria) is a clinical diagnosis characterized by recurrent urticaria ... urticaria-score- sheet.pdf From Puxeddu, et al. (2019). [11].Puxeddu et al., "Biomarkers in chronic spontaneous urticaria: ... Shift from Acute Urticaria to Chronic Spontaneous Urticaria?. •Majority of literature reports focus on immediate onset and ...
Aquagenic urticaria is an extremely rare condition that causes sufferers to break into hives at the slightest contact with ... Can You Be Allergic To Water? Symptoms, Causes, And Treatments For Aquagenic Urticaria. Nov 22, 2016 01:20 PM. By Dana Dovey ... Although we need water to stay alive, some individuals have a severe allergy to it, called aquagenic urticaria. Photo Courtesy ... Of all the allergies in the world, aquagenic urticaria - an allergy to water that causes patients to develop hives after coming ...
Free, official info about 2015 ICD-9-CM diagnosis code 708.1. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
Ive had pressure urticaria and hives since 1998. I have to take a daily antihistamine to prevent the worst symptoms, but there ... Pressure Urticaria I am a thirty-five year women who has suffered from pressure urticaria or dermographism for approximately ... Celiac Disease and Pressure Urticaria. I have only been dealing with this hives problem for about a month, not long after being ...
Hives (urticaria) on the arm. Hives (urticaria) are raised, red, itchy welts, seen here on the arm. The majority of urticaria ...
Urticaria :: Non allergic urticaria - hives, urticarea, nettle rash. *Urticaria :: Allergic urticaria - hives, urticarea, ... Tags Body, Fever, Remedy, Repertory, Rubric, Treatment, Urticaria, Weakness. Health :: Sexual Disorders ... Her husband came to report on the evening of 15th and told that her Urticaria was worse during menses. I looked up this rubric ... Ulcers :: Chronic ulcers, Urticaria - Kali Carb. Nov 20, 2005, Sun. by Sub-editor ...
Urticaria pigmentosa is an uncommon skin condition with reddish-brown lesions typically occurring in infants and children. In ... Urticaria pigmentosa is an uncommon skin condition marked by a rash that usually affects the neck, arms, legs and trunk of ... What causes urticaria pigmentosa?. The spots present contain a large number of mast (inflammatory) cells. Mast cells are immune ... Treating Urticaria Pigmentosa. Unfortunately for those suffering from this condition, there is no satisfactory treatment for ...
  • These wheals are a subset of urticaria (hives), and appear within minutes, in some cases accompanied by itching. (wikipedia.org)
  • Vibratory urticaria is a condition in which exposing the skin to vibration, repetitive stretching, or friction results in allergy symptoms such as hives (urticaria), swelling (angioedema), redness (erythema), and itching (pruritus) in the affected area. (medlineplus.gov)
  • Urticaria (hives) is a type I hypersensitivity reaction, where autoantibodies against IgE molecules are involved. (medscape.com)
  • Cold urticaria can become dangerous in rare cases , such as when hives appear all over the body after jumping into cold water. (ecarf.org)
  • Urticaria (hives) is a skin rash characterised by very itchy weals, with or without surrounding erythematous flares. (ausmed.com.au)
  • Many patients with chronic urticaria spend years in misery trying to find the cause of their hives, but the long-term approach should be for alleviation of their symptoms, according to a leading dermatologist. (mydr.com.au)
  • Epinephrine is under clinical development by ARS Pharmaceuticals and currently in Phase II for Chronic Urticaria Or Hives. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Chronic Urticaria Or Hives have a 52% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
  • Chronic urticaria (CU) is a recurrent skin condition characterised by hives, angioedema or both. (hospitalhealthcare.com)
  • Urticaria is an inflammatory skin condition characterised by itchy hives and swelling. (evaluate.com)
  • Urticaria is a group of diseases characterized by the development of wheals (hives), angioedema (see chapter 1.1.2), or both. (cyberderm.net)
  • Hives, also known as urticaria, are an outbreak of swollen, pale red bumps, patches, or welts on the skin that appear suddenly -- either as a result of allergies, or for other reasons. (drsearles.ca)
  • These hives can also occur along with other forms of urticaria. (drsearles.ca)
  • The cause of this type of hives is usually more difficult to identify than those causing acute urticaria and/or angioedema. (drsearles.ca)
  • [ 1 ] Approximately 37% of patients with chronic spontaneous urticaria also have pressure urticaria. (medscape.com)
  • For how long should we use omalizumab in chronic spontaneous urticaria? (worldallergy.org)
  • Omalizumab is a monoclonal anti-IgE antibody that has been approved for the treatment of refractory chronic spontaneous urticaria (CSU) in many parts of the world since 2013 (1). (worldallergy.org)
  • 2. Giménez-Arnau AM. Omalizumab for treating chronic spontaneous urticaria: an expert review on efficacy and safety. (worldallergy.org)
  • Expert opinion: defining response to omalizumab in patients with chronic spontaneous urticaria. (worldallergy.org)
  • 5. Weller K, Zuberbier T, Maurer M. Clinically relevant outcome measures for assessing disease activity, disease control and quality of life impairment in patients with chronic spontaneous urticaria and recurrent angioedema. (worldallergy.org)
  • Online Facebook group "Chronic Spontaneous Urticaria After COVID-19 Vaccine Support Group, " 6k members. (researchgate.net)
  • If not chronic spontaneous urticaria, what else? (iasp-pain.org)
  • Chronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 - 4% of the general population. (iasp-pain.org)
  • In this segment of his interview with HCPLive , Raj Chovatiya, MD, PhD, spoke with the editorial team about the contents of his talk 'Diving Below the Surface of Type 2 Inflammation in atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria: Implications for Clinical Practice. (consultantlive.com)
  • During this interview, he was asked about the mechanisms of Type 2 inflammation in atopic dermatitis (AD), prurigo nodularis (PN), and chronic spontaneous urticaria (CSU). (consultantlive.com)
  • And it's really come to our attention that, as we've learned more about other states like prurigo nodularis and, more recently, chronic spontaneous urticaria, there are some really interesting connections in terms of similar cytokines across all of these. (consultantlive.com)
  • In the case of chronic spontaneous urticaria, again, chronic pruritus that's usually greater than 6 weeks plus, and lesions that come and go," he said. (consultantlive.com)
  • Abstract Background Patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) report difficulty with sleep. (figshare.com)
  • Novartis and Roche's Xolair has had a monopoly on the chronic spontaneous urticaria market for some time, but this is expected to change this year with the approval of Sanofi and Regeneron's Dupixent for the skin disorder. (evaluate.com)
  • First-line treatment for chronic spontaneous urticaria (CSU) is H1-antihistamines but many patients remain symptomatic even on treatment. (evaluate.com)
  • Acute spontaneous urticaria: Occurrence of spontaneous wheals, angioedema or bothfor less than 6 weeks. (cyberderm.net)
  • Chronic Spontaneous Urticaria: Limited investigations are recommended: FBC, automated chemistry, CRP and/or ESR. (cyberderm.net)
  • Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients. (medscape.com)
  • Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis. (medscape.com)
  • The US Food and Drug Administration (FDA) has issued a complete response letter regarding the application for approval of dupilumab for the treatment of chronic spontaneous urticaria (CSU) in people aged 12 years and older, according to the manufacturers, Regeneron and Sanofi. (medscape.com)
  • Urticaria needs to be differentiated from other medical conditions where wheals, angioedema, or both can occur, e.g. anaphylaxis, autoinflammatory syndromes, urticarial vasculitis, orbradykinin-mediated angioedema including hereditary angioedema (HAE). (cyberderm.net)
  • Urticaria may be associated with angioedema: Pronounced erythematous or skin colored swelling of the lower dermis and subcutis or mucous membranes. (cyberderm.net)
  • Laboratory tests and identified diagnoses in patients with physical and chronic urticaria and angioedema: A systematic review. (medscape.com)
  • Chronic urticaria and angioedema associated with thyroid autoimmunity: review and therapeutic implications. (medscape.com)
  • An inciting event or etiology is usually not identified for patients with chronic urticaria-hence the term chronic idiopathic urticaria (CIU) is often used. (medscape.com)
  • In chronic idiopathic urticaria (CIU), the mast cells are inappropriately activated. (medscape.com)
  • Interestingly, one study found that a quarter of patients with CU experienced sleep-related breathing disorders and in a small study of 31 patients with chronic idiopathic urticaria, 13 were diagnosed with obstructive sleep apnoea (OSA), one of whom had severe OSA. (hospitalhealthcare.com)
  • Patients with treatment-resistant chronic idiopathic urticaria may respond more successfully to antihistamine therapy augmented with dapsone or colchicine. (dermatologytimes.com)
  • Bansal AS, Hayman GR. Graves disease associated with chronic idiopathic urticaria: 2 case reports. (medscape.com)
  • Urticaria pigmentosa is an uncommon skin condition marked by a rash that usually affects the neck, arms, legs and trunk of children and young adults. (skinsite.com)
  • What causes urticaria pigmentosa? (skinsite.com)
  • We do not currently know why people with urticaria pigmentosa have abnormal collections of mast cells in their skin. (skinsite.com)
  • It is most common in infants, and most children who develop urticaria pigmentosa before the age of five will have resolution of the condition by adolescence or early adulthood. (skinsite.com)
  • Unfortunately for those suffering from this condition, there is no satisfactory treatment for urticaria pigmentosa. (skinsite.com)
  • mastocitosis, mutaci n D816V, urticaria pigmentosa. (medigraphic.com)
  • Bone marrow findings in adult patients with urticaria pigmentosa. (medigraphic.com)
  • Urticaria pigmentosa may manifest as reddish plaque-like lesions on the skin. (msdmanuals.com)
  • The infant shown here has profuse papulonodular and plaque lesions of urticaria pigmentosa. (msdmanuals.com)
  • Cold urticaria can be diagnosed by placing an ice cube on the skin for five minutes. (mayoclinic.org)
  • If you have cold urticaria, a raised bump (hive) will form a few minutes after the ice cube is removed. (mayoclinic.org)
  • In some cases, cold urticaria is caused by an underlying condition that affects the immune system, such as an infection or cancer. (mayoclinic.org)
  • In some people, cold urticaria goes away on its own after weeks or months. (mayoclinic.org)
  • Normally prescribed to treat asthma, this drug has been used successfully to treat people with cold urticaria who didn't respond to other medications. (mayoclinic.org)
  • If you have cold urticaria because of an underlying health problem, you may need medications or other treatment for that condition as well. (mayoclinic.org)
  • They can be used to treat mild symptoms of cold urticaria or to prevent a reaction. (mayoclinic.org)
  • Mauer M. Cold urticaria. (mayoclinic.org)
  • Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. (mayoclinic.org)
  • ECARF spoke to Dr Markus Magerl of Allergie-Centrum-Charité in Berlin about the strange phenomenon of cold urticaria. (ecarf.org)
  • People who react in such a way to a cold stimulus within five to ten minutes probably have a specific type of urticaria , known as cold urticaria . (ecarf.org)
  • Doctors generally use a provocation test to confirm a diagnosis of cold urticaria. (ecarf.org)
  • Various medications are available for the treatment of cold urticaria. (ecarf.org)
  • This phase 1b trial will evaluate the effects of EP262 in subjects with Chronic Inducible Urticaria (CIndU), including symptomatic dermographism and cold urticaria. (ichgcp.net)
  • We report on a case of solar urticaria with elevated protoporphyrin in the stool. (karger.com)
  • This photo shows solar urticaria in a woman who had been wearing a tank top. (msdmanuals.com)
  • In some forms of urticaria the lesions may be papular (e.g. cholinergic urticaria). (cyberderm.net)
  • It belongs to a class of disorders called physical urticarias in which allergy symptoms are brought on by direct exposure to factors such as pressure, heat, cold, or sunlight. (medlineplus.gov)
  • Researchers suggest that once the subunits are disconnected, the beta subunit signals the mast cells to react and produce the allergy symptoms in the skin that occur in vibratory urticaria. (medlineplus.gov)
  • Urticaria occurring at the time of antibiotic use is often due to the underlying infection rather than an allergy to the antibiotic. (rch.org.au)
  • Although we need water to stay alive, some individuals have a severe allergy to it, called aquagenic urticaria. (medicaldaily.com)
  • Epinephrine (ARS-1) is under development for the treatment of anaphylaxis caused by severe allergic reactions to medications, insect bites, asthma, urticaria, seasonal allergic rhinitis, food allergy and infectious rhinitis. (pharmaceutical-technology.com)
  • Off-label augmentation with leukotriene receptor antagonists for refractory chronic urticaria appears to be safe and effective, according to late-breaking results presented at American College of Allergy, Asthma and Immunology (ACAAI) 2023 Annual Scientific Meeting. (dermatologytimes.com)
  • Daniel G. Rayner, who presented the results of the systematic review and meta-analysis on behalf of the American Academy of Allergy, Asthma & Immunology/ACAAI Joint Task Force on Practice Parameters Chronic Urticaria Guideline Development Group, noted this was the first study to appraise and synthesis evidence on leukotriene receptor antagonists in the treatment of chronic urticaria. (dermatologytimes.com)
  • 1417-1426), is the result of a consensus reached during a panel discussion at the Third International Consensus Meeting on Urticaria, Urticaria 2008 , a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU‐funded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO). (mcmaster.ca)
  • The causes can be similar to those of acute urticaria but can also include your immune system, chronic infections, hormonal disorders, and tumors. (webmd.com)
  • For non-acute urticaria, around 0.1-0,6% in the general population. (cyberderm.net)
  • Acute urticaria: Does not require a diagnostic workup, as it is usually self-limiting. (cyberderm.net)
  • Patients with chronic inducible urticaria (CIndU) have increased serum levels of IgE. (medscape.com)
  • Standardized provocation testing to diagnose chronic inducible urticaria are required for an accurate diagnosis. (cyberderm.net)
  • In addition to CSU, dupilumab is being studied for treatment of chronic inducible urticaria triggered by cold (LIBERTY-CINDU CUrIADS program) in an ongoing phase 3 trial and for treatment of a broad range of other diseases driven by type 2 inflammation. (medscape.com)
  • However, it should be noted that in some cases, urticaria occurs in response to contact with cold and, therefore, by cooling the area we would only exacerbate the problem.The truth is that contact urticaria never benefits from hot, quite the opposite, you should avoid applying heat over the affected areas, in order not to worsen urticaria symptoms. (botanical-online.com)
  • IgE-mediated (Type I Reaction) foods, medications, bee or wasp toxins, foreign proteins and other exogenous materials such as latex or plant products (contact urticaria). (cyberderm.net)
  • Contact urticaria deviates from regular contact dermatitis in the type of clinical reaction, its time sequence, the causal agents, and the pathogenetic mechanism. (escd.org)
  • It should be pointed out, however, that a non-immunological variant of contact urticaria also exists. (escd.org)
  • Pressure urticaria is an uncommon form of physical urticaria, a subset of chronic urticaria, which presents with erythematous swelling at sites of pressure. (medscape.com)
  • Pressure urticaria may occur immediately (within minutes) or, more commonly, 4-6 hours after a pressure stimulus. (medscape.com)
  • The pathogenesis of delayed pressure urticaria (DPU) is relatively unknown. (medscape.com)
  • Despite these findings, histamine is unlikely to be the sole mediator in pressure urticaria. (medscape.com)
  • This is further demonstrated in the inconsistent effectiveness of antihistamine treatment in pressure urticaria. (medscape.com)
  • and leukotrienes have also been found in lesional skin of pressure urticaria patients. (medscape.com)
  • I am a thirty-five year women who has suffered from pressure urticaria or dermographism for approximately three years now. (healthy-skincare.com)
  • The UAS works as a prospective, daily diary focusing on the two key urticaria symptoms wheals and pruritus, with a score ranging from 0 to 42 in 7 days (UAS7). (worldallergy.org)
  • Chronic urticaria is termed when patients have ongoing urticaria for more than 6 weeks. (medscape.com)
  • [ 2 ] Papular urticaria was evident in 2.24% of 5250 first-time pediatric patients, with 6029 diagnoses in one pediatric dermatology service survey. (medscape.com)
  • [ 4 ] A Nigerian survey of 491 pediatric dermatoses in 441 patients found papular urticaria in 6.7% of them. (medscape.com)
  • The presence of immunoglobulin and complement deposits in the skin of some patients with papular urticaria suggests that the lesions may be due to a cutaneous vasculitis. (medscape.com)
  • There is now evidence for safety and efficacy in long-term treatment of chronic urticaria in patients that still need the drug after several years (9-10). (worldallergy.org)
  • Speaking at the Australian Doctor Dermatology Academy in Sydney on Saturday, Professor Sinclair said there were a few proven triggers for urticaria worth exploring, such as aspirin, codeine, exercise and heat, but for 90% of patients the condition persisted without a specific trigger being identified. (mydr.com.au)
  • If urticaria patients don't show a "signal" in the reporting system, w e can't get our problem addressed. (researchgate.net)
  • A study of patients with chronic urticaria suggests that a quarter could be at an intermediate risk of developing obstructive sleep apnoea. (hospitalhealthcare.com)
  • Given that a proportion of patients with chronic urticaria have sleep-related breathing problems and even OSA, the precise nature of this relationship and whether CU and OSA are causally related remains uncertain. (hospitalhealthcare.com)
  • 35. In addition, patients completed the Urticaria Activity Score summed over 7 days ( UAS7 ) which assesses itch severity and hive count. (hospitalhealthcare.com)
  • Further questionnaires completed included a chronic urticaria quality of life questionnaire and the urticaria control test (UCT), which defines patients as being either poorly controlled or well-controlled. (hospitalhealthcare.com)
  • There was also a significant association between UCT categories and STOP-Bang risk categories, such that 82.4% of patients with controlled urticaria had a low risk of OSA. (hospitalhealthcare.com)
  • The authors concluded that their data suggested that a considerable proportion of patients with chronic urticaria were at intermediate to high risk for OSA, based on the STOP-Bang questionnaire. (hospitalhealthcare.com)
  • Almost half of responding UCARE physicians were involved in COVID-19 patient care, which negatively impacted on the care of urticaria patients. (eur.nl)
  • However, in an earlier report, skin biopsies of seven of his female patients with chronic, antihistamine-resistant urticaria showed a type of inflammatory-cell infiltrate that was more rich in neutrophils and eosinophils than lymphocytes, a subtype that he and a colleague proposed calling polymorphonuclear cell-predominant urticaria (PPU) (Zavadak D, Tharp MD. (dermatologytimes.com)
  • More specifically, Dr. Tharp and his colleague evaluated 77 patients who were referred to the Rush University Department of Dermatology with chronic, antihistamine-resistant urticaria for inclusion in this study. (dermatologytimes.com)
  • Are autoantibodies present in patients with subacute and chronic urticaria? (medscape.com)
  • Kasumagic-Halilovic E, Beslic N, Ovcina-Kurtovic N. Thyroid Autoimmunity in Patients with Chronic Urticaria. (medscape.com)
  • In a poster presented at the European Academy of Dermatology and Venereology (EADV) Congress, which was held in October in Berlin, researchers found that patients with CSU who were treated with dupilumab experienced a significant drop in urticaria and an improvement in general and disease-specific health-related quality of life at week 24. (medscape.com)
  • Morphologic and immunohistochemical evidence suggest that a type I hypersensitivity reaction plays a central role in the pathogenesis of papular urticaria. (medscape.com)
  • Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. (medscape.com)
  • Oenothera biennis ) Evening primrose has got antihistamine properties that could be used in the treatment of urticaria, helping reduce the appearance of the characteristic "wheals" and reducing the itching. (botanical-online.com)
  • She reported improvement in Urticaria but complained that swelling has appeared on both of her upper eyelids which was worrying her. (spiritindia.com)
  • Among these findings was improvement in urticaria severity, with a mean difference in UAS7 (0-42) of -5.17 (95%CI -6.53 to -3.80). (dermatologytimes.com)
  • Some home remedies might prove useful tips to reduce the unpleasant symptoms of urticaria. (botanical-online.com)
  • The mast cell-activating signals in urticaria are ill defined and likely to be heterogeneous and diverse (IgE-mediated Type I-reaction, non specific histamine liberators, activation of complement, autoimmune mediated urticaria - IgG against IgE or against high affinity IgE-receptor and IgE against autoantigens, as well as other poorly understood mechanisms). (cyberderm.net)
  • Mast cells are critically involved in serum-mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation. (medscape.com)
  • Contemporary approaches to the diagnosis and management of physical urticaria. (mayoclinic.org)
  • The diagnosis and management of acute and chronic urticaria: 2014 update. (medscape.com)
  • Hypersensitivity reactions, with urticaria, anaphylaxis and one fatility, have been reported and the label recommends that "further injection be discontinued" (see below). (aaaai.org)
  • There is wide evidence that some supplements are particularly interesting in the treatment of allergic diseases such as allergic urticaria. (botanical-online.com)
  • More information about urticaria and its natural treatment . (botanical-online.com)
  • 3. Zuberbier T, Maurer M. Omalizumab for the treatment of chronic urticaria. (worldallergy.org)
  • He was referred to our hospital for treatment of chronic urticaria. (efim.org)
  • Late-breaking data adds important safety and efficacy data for leukotriene receptor antagonists augmentation in chronic urticaria treatment. (dermatologytimes.com)
  • Urticaria has a profound impact on the quality of life and effective treatment is, therefore, required. (mcmaster.ca)
  • Successful treatment of chronic urticaria with leukotriene antagonists. (medscape.com)
  • Viagra is indicated for the treatment of erectile dysfunction in men allegra dose urticaria . (onlinehome.us)
  • Physical urticaria: classification and diagnostic guidelines. (wikipedia.org)
  • Physical urticarias have been estimated to occur in up to 5 per 1,000 people. (medlineplus.gov)
  • Abajian M, Mlynek A, Maurer M. Physical urticaria. (medlineplus.gov)
  • Physical urticarias. (mayoclinic.org)
  • Because there are no definitive diagnostic tests for urticaria, evaluation largely relies on history and physical examination. (msdmanuals.com)
  • Papular urticaria is a common and often annoying disorder manifested by chronic or recurrent papules caused by a hypersensitivity reaction to the bites of mosquitoes, fleas, bedbugs, and other insects. (medscape.com)
  • Ventura MT, Napolitano S, Menga R, Cecere R, Asero R. Anisakis simplex Hypersensitivity Is Associated with Chronic Urticaria in Endemic Areas. (medscape.com)
  • Dermatographic urticaria is a skin disorder and one of the most common types of urticaria, affecting 2-5% of the population. (wikipedia.org)
  • In addition, despite no known racial or sex predisposition, certain ethnic groups (specifically Asians) may be more predisposed to more intense reactions, and a small Nigerian study reported a slight female predominance for skin diseases such as papular urticaria and atopic dermatitis. (medscape.com)
  • However, an undesirable consequence of COVID-19 vaccination has been the frequent incidence of urticaria , a type of adverse skin manifestations . (bvsalud.org)
  • While cromoglycate, which prevents histamine from being released from mast cells, is used topically in rhinitis and asthma, it is not effective orally for treating chronic urticaria. (wikipedia.org)
  • Urticaria is a mast cell-driven disease. (cyberderm.net)
  • Urticaria results from the release of histamine, bradykinin, kallikrein, and other vasoactive substances from mast cells and basophils in the superficial dermis, resulting in intradermal edema caused by capillary and venous vasodilation and occasionally caused by leukocyte infiltration. (msdmanuals.com)
  • The first outbreak of urticaria can lead to other reactions on body parts not directly stimulated, scraped, or scratched. (wikipedia.org)
  • The majority of urticaria develop as a result of allergic reactions. (limamemorial.org)
  • Update on Omalizumab for Urticaria: What's New in the Literature from Mechanisms to Clinic. (worldallergy.org)
  • Vibratory urticaria can be caused by a mutation in the ADGRE2 gene. (medlineplus.gov)
  • Some people with vibratory urticaria do not have a mutation in the ADGRE2 gene. (medlineplus.gov)
  • Vibratory Urticaria Associated with a Missense Variant in ADGRE2. (medlineplus.gov)
  • EAACI/GA²LEN/EDF/WAO Guideline: definition, classification and diagnosis of urticaria. (mcmaster.ca)
  • Rayner concluded that there is a high certainty of evidence showing that augmenting antihistamines with leukotriene receptor antagonists results in improvements in urticaria severity. (dermatologytimes.com)
  • They concluded their research indicatedthe impact of leukotriene receptor antagonists on serious neuropsychiatric events while treating urticaria remains unclear. (dermatologytimes.com)
  • The histopathologic pattern in papular urticaria consists of mild subepidermal edema, extravasation of erythrocytes, interstitial eosinophils, and exocytosis of lymphocytes. (medscape.com)
  • Chronic urticaria often lasts months to years, eventually resolving without a cause being found. (msdmanuals.com)
  • [ 5 ] . Papular urticaria is also common in Colombia, linked with exposure to indoor fleas and poverty. (medscape.com)
  • In a study of the specific pattern of flea antigen recognition by IgG subclass and IgE during the progression of papular urticaria caused by flea bite, variations in the antibody responses of both subclasses to flea antigens were identified. (medscape.com)
  • Possibly work related dermatitis and urticaria were reported by four workers. (cdc.gov)
  • Case reports have been published on face mask-induced allergic contact dermatitis and urticaria. (lu.se)
  • Liquid severe reaction tadalafil tablets and sperm motility for puppy uti much ds without allegra dose urticaria . (onlinehome.us)
  • Despite the prevalence of this issue, there is currently a lack of clinical evidence exploring the potential utility of acupuncture as a therapeutic approach to managing urticaria arising after COVID-19 vaccination . (bvsalud.org)