The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in children. It is characterized by the multiple small reddish-brown pigmented pruritic macules and papules.
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Skin lesions due to abnormal infiltration of MAST CELLS. Cutaneous mastocytosis is confined to the skin without the involvement of other tissues or organs, and is mostly found in children. The three major variants are: URTICARIA PIGMENTOSA; diffuse cutaneous mastocytosis; and SOLITARY MASTOCYTOMA OF SKIN.
A heterogenous group of disorders characterized by the abnormal increase of MAST CELLS in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).
Hereditary, progressive degeneration of the neuroepithelium of the retina characterized by night blindness and progressive contraction of the visual field.

Cutaneous and systemic manifestations of mastocytosis. (1/45)

Mastocytosis is characterized by an excessive number of apparently normal mast cells in the skin and, occasionally, in other organs. Characteristic skin lesions, called urticaria pigmentosa, are present in most patients, but clinical presentation can vary from a pruritic rash to unexplained collapse and sudden death. These lesions are typically tan to red-brown macules that appear on the trunk and spread symmetrically. Patients with mastocytosis often have a long history of chronic and acute symptoms that were unrecognized as mastocytosis. Skin lesions may or may not accompany systemic mastocytosis. Systemic disease may involve the gastrointestinal tract, the bone marrow or other organs. Even when the disease is considered as a possibility by the physician, the diagnosis can be difficult because of special technical requirements necessary for biopsy and because of the problems with biochemical testing. Drug therapy is initiated to stabilize mast cell membranes, to reduce the severity of the attacks and to block the action of inflammatory mediators. The mainstay of therapy is histamine H1 and H2 blockers and the avoidance of triggering factors.  (+info)

Increased formation of thromboxane in vivo in humans with mastocytosis. (2/45)

Clinical manifestations of mastocytosis are mediated, at least in part, by release of the mast cell mediators histamine and prostaglandin D2. It has been previously reported that in addition to prostaglandin D2, mast cells produce other eicosanoids, including thromboxane. Nonetheless, little information exists regarding the formation of other prostanoids in vivo. The most accurate method to examine the systemic production of eicosanoids in vivo is the quantitation of urinary metabolites. We previously developed a highly accurate assay employing mass spectrometry to measure a major urinary metabolite of thromboxane, 11-dehydro-thromboxane B2, in humans. We utilized this assay to quantitate thromboxane production in 17 patients with histologically proven mastocytosis. We report that thromboxane formation was significantly increased (>2 SD above the mean) in at least one urine sample from 65% of patients studied. Of these, 91% of patients with documented systemic involvement had elevated thromboxane generation. In addition, endogenous formation of thromboxane was highly correlated with the urinary excretion of the major urinary metabolite of prostaglandin D2 (r = 0.98) and Ntau-methylhistamine (r = 0.91), suggesting that the cellular source of increased thromboxane in vivo could be the mastocyte. Enhanced thromboxane formation in patients with this disorder is unlikely to be of platelet origin as other markers of platelet activation, platelet factor 4 and beta-thromboglobulin, were not increased in three patients with marked overproduction of thromboxane. Furthermore, the recovery of 11-dehydro-thromboxane B2 excretion in two patients after the administration of aspirin occurred significantly more rapidly than the recovery of platelet thromboxane generation. These studies, therefore, report that thromboxane production is significantly increased in the majority of patients with mastocytosis that we examined and provide the basis to elucidate the role of this eicosanoid in disorders of mast cell activation.  (+info)

Association of the Q576R polymorphism in the interleukin-4 receptor alpha chain with indolent mastocytosis limited to the skin. (3/45)

Gain-of-function mutations in c-kit, which appear to contribute to mast cell hyperplasia, have been detected in both limited and aggressive forms of mastocytosis, suggesting that other mutations or polymorphisms may contribute to the clinical phenotype. Because addition of interleukin-4 (IL-4) to mast cell cultures is reported to induce apoptosis, the hypothesis was considered that individuals carrying the gain-of-function polymorphism Q576R in the cytoplasmic domain of the alpha-subunit of the IL-4 receptor (IL-4R) might be relatively resistant to the gain-of-function mutation in c-kit. To assess this possibility, 36 patients with either cutaneous or systemic mastocytosis were studied for association with the Q576R polymorphism. The Q576R polymorphism was found more frequently in those with disease limited to skin and who exhibited lower levels of surrogate disease markers. These data suggest that the Q576R IL-4R alpha- chain polymorphism may mitigate disease expression and confer a better prognosis in patients with mastocytosis. (Blood. 2001;98:880-882)  (+info)

One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes. (4/45)

The prognostic significance of somatic activating codon 816 c-kit mutations in pediatric urticaria pigmentosa has not yet been established in detail. Detection of such mutations in archival paraffin-embedded biopsies is usually hampered by an abundance of surrounding normal cells. Here we describe a method for the selective amplification and specific detection of c-kit mutation Asp816-->Val in complete tissue sections cut from up to 24-year-old paraffin blocks. Peptide nucleic acid-mediated polymerase chain reaction clamping of the wild-type allele was combined with on-line mutation detection using oligonucleotide hybridization probes. In DNA extracted from HMC-1 cells heterozygously carrying the c-kit mutation Asp816-->Val, the one-tube assay allowed specific detection of this mutation in a more than 1000-fold excess of normal background DNA within 1 hour and without the need for additional analytical steps. In a series of 38 cases with pediatric urticaria pigmentosa we detected c-kit codons 815 and 816 mutations in 16 cases. Mutation detection did not correlate with clinical outcome after a mean follow-up of 11.2 years. In conclusion, the procedure described may represent an ideal screening tool for all kinds of clinical applications, using point mutations as markers of, for example, early events in carcinogenesis, circulating metastatic tumor cells, and minimal residual disease.  (+info)

Gastrointestinal involvement in systemic mastocytosis. (5/45)

Four consecutive patients with systemic mastocytosis were studied. One patient had a malabsorption syndrome with only minor histological changes of the intestinal mucosa. Another patient with ulcer diathesis had a gastric secretory pattern resembling Zollinger-Ellison syndrome. Serum gastrin and histamine levels were consistently normal in all patients. Endoscopy of stomach and colon disclosed urticaria-like papulae either spontaneously or after topical provocation in all patients. No increase of mast cells was found in multiple mucosal biopsies. A markedly increased gastric tissue content of histamine was found, however, in the three patients studied. The findings suggest that urticaria-like lesions associated with a high tissue content of histamine may be more important that hyperhistaminaemia in causing the various gastrointestinal symptoms.  (+info)

CURRENT CONCEPTS IN DERMATOLOGY. II. THE SKIN AND SYSTEMIC DISEASE. (6/45)

Many systemic diseases have cutaneous manifestations. In some diseases skin involvement is the predominant factor (Behcet's syndrome, urticaria pigmentosa, discoid lupus erythematosus and pseudoxanthoma elasticum); in others the skin manifestations, when present, are an important part of the condition (sarcoidosis, systemic lupus erythematosus, hypersensitivity angiitis, porphyria). This report includes descriptions of and comments on these cutaneous manifestations. Erythema nodosum and erythema multiforme are reaction patterns of the skin and mucous membrane which may have many causes. The relationship between discoid and systemic lupus erythematosus is discussed. There is little doubt that these are variations of the same basic disease process, even though the prognoses are very different.  (+info)

A study on cercarial dermatitis in Khuzestan province, south western Iran. (7/45)

BACKGROUND: Cercarial dermatitis' or swimmer's itch' is an itchy inflammatory response to the penetration of the skin by non-human schistosome parasites. In the hot season, (May to September) in Khuzestan province in the south west of Iran, swimming in canals and agriculture activities in swampy areas are common. This survey was made on people from villages north of Ahwaz city in south west Iran, to estimate cercarial dermatitis in this region. METHODS: 2000 people were observed for clinical signs of cercarial dermatitis. Also 2000 Lymnaea gedrosiana snails were collected from agriculture canals and examined for animal schistosome cercariae during 1998-2000. RESULTS: From this survey 1.1% of people had pruritic maculopapular rash on their feet, hands or other parts of body. From the total of examined snails, 2.4% were found to be infected with bird schistosome cercariae including Trichobilharzia species. CONCLUSION: Cercarial dermatitis could be a health problem in this area. This is the first report of cercarial dermatitis from this region of Iran.  (+info)

Solitary mastocytoma causing recurrent blistering in infancy. (8/45)

Two children with solitary mastocytoma in infancy, both of whom had recurrently blistering scalp lesions, are reported in order to emphasise the diagnostic importance of this distinctive history.  (+info)

Urticaria pigmentosa is a rare mast cell disorder, characterized by the development of brownish-red, raised lesions (maculopapules) on the skin. These lesions are often found on the trunk and proximal extremities, but can occur anywhere on the body. They are typically asymptomatic, but may become itchy or even painful when subjected to friction, heat, or emotional stress. In some cases, these lesions may also release histamine, leading to symptoms such as flushing, headache, and hypotension. Urticaria pigmentosa is more common in children than adults, and typically resolves on its own over time. However, in some cases it can persist into adulthood or even progress to systemic mastocytosis, a more severe form of the disorder that can affect internal organs.

Urticaria, also known as hives, is an allergic reaction that appears on the skin. It is characterized by the rapid appearance of swollen, pale red bumps or plaques (wheals) on the skin, which are often accompanied by itching, stinging, or burning sensations. These wheals can vary in size and shape, and they may change location and appear in different places over a period of hours or days. Urticaria is usually caused by an allergic reaction to food, medication, or other substances, but it can also be triggered by physical factors such as heat, cold, pressure, or exercise. The condition is generally harmless, but severe cases of urticaria may indicate a more serious underlying medical issue and should be evaluated by a healthcare professional.

Cutaneous mastocytosis is a condition characterized by the abnormal accumulation of mast cells in the skin. Mast cells are a type of immune cell that releases chemicals such as histamine, heparin, and leukotrienes, which play a role in allergic reactions and inflammation. In cutaneous mastocytosis, the excessive buildup of mast cells can cause various skin symptoms, including redness, itching, swelling, and formation of lesions or tumors.

The condition is typically divided into several subtypes based on the age of onset and the clinical presentation. The most common form in children is called urticaria pigmentosa, which presents as small, reddish-brown spots or bumps that may become raised and itchy when scratched or rubbed (Darier's sign). In adults, a more severe form known as diffuse cutaneous mastocytosis can occur, where the entire skin becomes thickened, red, and swollen.

Cutaneous mastocytosis is usually diagnosed based on the patient's medical history, physical examination, and results from skin biopsies. Treatment typically focuses on relieving symptoms and preventing mast cell activation. Medications such as antihistamines, topical steroids, and mast cell stabilizers may be used to control itching, flushing, and other symptoms associated with the condition. In some cases, systemic therapies or phototherapy may also be recommended.

Mastocytosis is a group of rare disorders caused by the accumulation of abnormal number of mast cells in various tissues of the body, particularly the skin and internal organs such as the bone marrow, liver, spleen, and gastrointestinal tract. Mast cells are types of white blood cells that play an important role in the immune system, releasing chemicals like histamine, heparin, and leukotrienes during allergic reactions or injury to help protect the body. However, excessive accumulation of mast cells can lead to chronic inflammation, tissue damage, and various symptoms.

There are two main types of mastocytosis: cutaneous mastocytosis (CM) and systemic mastocytosis (SM). CM primarily affects the skin, causing redness, itching, hives, and other skin abnormalities. SM, on the other hand, involves internal organs and can be more severe, with symptoms such as diarrhea, stomach pain, fatigue, bone pain, and anaphylaxis (a life-threatening allergic reaction).

Mastocytosis is typically caused by genetic mutations that lead to the overproduction of mast cells. The diagnosis of mastocytosis usually involves a combination of physical examination, medical history, blood tests, skin biopsy, and bone marrow aspiration. Treatment options depend on the type and severity of the disease and may include antihistamines, corticosteroids, chemotherapy, targeted therapy, and in severe cases, stem cell transplantation.

Retinitis pigmentosa (RP) is a group of rare, genetic disorders that involve a breakdown and loss of cells in the retina - a light-sensitive tissue located at the back of the eye. The retina converts light into electrical signals which are then sent to the brain and interpreted as visual images.

In RP, the cells that detect light (rods and cones) degenerate more slowly than other cells in the retina, leading to a progressive loss of vision. Symptoms typically begin in childhood with night blindness (difficulty seeing in low light), followed by a gradual narrowing of the visual field (tunnel vision). Over time, this can lead to significant vision loss and even blindness.

The condition is usually inherited and there are several different genes that have been associated with RP. The diagnosis is typically made based on a combination of genetic testing, family history, and clinical examination. Currently, there is no cure for RP, but researchers are actively working to develop new treatments that may help slow or stop the progression of the disease.

... is a rare disease, affecting fewer than 200,000 people in the United States. Urticaria Dermatographic ... it most likely signifies the presence of urticaria pigmentosa.[citation needed] There are no permanent cures for urticaria ... Urticaria pigmentosa is characterized by excessive amounts of mast cells in the skin. Red or brown spots are often seen on the ... Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type): 616 ) is the most common ...
They may include, but are not limited to Fatigue Skin lesions (urticaria pigmentosa), itching, and dermatographic urticaria ( ... Diagnosis of urticaria pigmentosa (cutaneous mastocytosis, see above) can often be done by seeing the characteristic lesions ... Unna, Paul Gerson; Unna (1887). Beiträge zur Anatomie und Pathogenese der Urticaria simplex und Pigmentosa [Contributions to ... Urticaria pigmentosa was first described in 1869. The first report of a primary mast cell disorder is attributed to Unna, who ...
He also made contributions in his research of molluscum contagiosum, melanosis lenticularis progressiva, urticaria pigmentosa, ...
... sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa. In ... Dermatographic urticaria Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs". Journal of ...
"Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa ...
... and in 1869 provided an early description of urticaria pigmentosa. Of his five brothers, the eldest was the noted classical ... He made important contributions in the research of ocular albinism, retinitis pigmentosa and hereditary night blindness. Prior ...
... urticaria pigmentosa, and post-inflammatory hyperpigmentation. In cases of post-inflammatory hyperpigmentation, it is important ... "The Histopathology of Urticaria Revisited-Clinical Pathological Study". The American Journal of Dermatopathology. 39 (10): 753- ...
Solar urticaria List of cutaneous conditions Cockayne syndrome Xeroderma pigmentosum Nucleotide excision repair Rapini, Ronald ...
The typical cutaneous mast cell infiltrates of urticaria pigmentosa are usually not present before, during, or after diagnosis ...
Urticaria pigmentosa (childhood type of generalized eruption of cutaneous mastocytosis) Venous lake (phlebectasis) Wildervanck ... heat contact urticaria Mast cell-independent urticaria Physical urticaria Primary cold contact urticaria Pressure urticaria ( ... deficiency Acute urticaria Adrenergic urticaria Anaphylaxis Aquagenic urticaria Cholinergic urticaria Chronic urticaria ( ... delayed pressure urticaria) Reflex cold urticaria Schnitzler syndrome Secondary cold contact urticaria Solar urticaria Systemic ...
... urticaria pigmentosa MeSH C04.557.450.565.465.750 - mastocytosis, systemic MeSH C04.557.450.565.465.750.500 - leukemia, mast- ...
Urocanase deficiency Urogenital adysplasia Urophathy distal obstructive polydactyly Urticaria pigmentosa Urticaria Urticaria- ...
... urticaria pigmentosa MeSH C17.800.621.936 - xeroderma pigmentosum MeSH C17.800.685.544 - pruritus ani MeSH C17.800.685.710 - ... urticaria pigmentosa MeSH C17.800.529.400 - nail-patella syndrome MeSH C17.800.529.406 - nails, ingrown MeSH C17.800.529.506 - ... xeroderma pigmentosum MeSH C17.800.621.166 - argyria MeSH C17.800.621.250 - Café au lait spots MeSH C17.800.621.430 - ... xeroderma pigmentosum MeSH C17.800.815.193 - dermatitis, atopic MeSH C17.800.815.255 - dermatitis, contact MeSH C17.800.815.255 ...
Kirghizian type Dermatopathia pigmentosa reticularis Dermatophytids Dermatophytosis Dermochondrocorneal dystrophy of François ... syndrome Dermal dysplasia Dermatitis herpetiformis Dermatocardioskeletal syndrome Boronne type Dermatographic urticaria ... Dupuytren's contracture Dust-induced lung disease Dwarfism Dwarfism bluish sclerae Dwarfism deafness retinitis pigmentosa ...
Some people may show erythema or severe pruritus alone, wheals of chronic urticaria, purpuric lesions resembling petechiae on ... and/or lesions mimicking prurigo pigmentosa. DH may be confused with many different cutaneous lesions, such as atopic ... as an increased risk factor for urticaria or anaphylaxis, and the sensitizing dose may include low-dose aspirin therapy used in ... dermatitis, eczema, urticaria, scabies, impetigo, polymorphic erythema and other autoimmune blistering diseases. DH is ...
Asthma Atopic dermatitis Atopic eczema Hay fever Urticaria Vernal conjunctivitis Acne rosacea Albinism Atopic dermatitis ... Vogt-Koyanagi-Harada syndrome Xeroderma pigmentosum Angiomatosis retinae (Von Hippel-Lindau disease) (retinocerebellar ...
Polymorphous light eruption (PMLE) Hydroa vacciniforme Chronic actinic dermatitis Actinic prurigo Solar urticaria Phototoxic ... Dermatomyositis Acne vulgaris Herpes simplex Lichen planus actinicus Porphyria cutanea tarda Xeroderma pigmentosum There are ...
A rare hereditary condition xeroderma pigmentosum (a defect in DNA repair) is thought to increase the risk of UV-light-exposure ... Digital camera ISO Bergaptene Heliotropism Photophobia Solar urticaria Snow blindness Photosensitizer Anderson, D.M.; Keith, J ...
... plaques and urticaria. Solar urticaria: A rare allergic reaction to the sun that occurs within minutes of exposure and fades ... Kraemer KH, DiGiovanna JJ (1993). "Xeroderma Pigmentosum". In Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJ, Stephens K, ... Certain genetic conditions, for example, xeroderma pigmentosum, increase a person's susceptibility to sunburn and subsequent ...
Xeroderma pigmentosum Porphyria cutanea tarda List of cutaneous conditions "Autosomal erythropoietic protoporphyria". Orphanet ... A new porphyria syndrome with solar urticaria due to protoporphyrinaemia". Lancet. 2 (7200): 448-451. doi:10.1016/S0140-6736(61 ...
Urticaria pigmentosa is a rare disease, affecting fewer than 200,000 people in the United States. Urticaria Dermatographic ... it most likely signifies the presence of urticaria pigmentosa.[citation needed] There are no permanent cures for urticaria ... Urticaria pigmentosa is characterized by excessive amounts of mast cells in the skin. Red or brown spots are often seen on the ... Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type): 616 ) is the most common ...
Urticaria Pigmentosa. definition. The most common form of mastocytosis. It occurs primarily in children and is characterized by ... Urticaria Pigmentosa. UMLS. Localized cutaneous mastocytosis, NOS, Urticaria Pigmentosa, Urticaria pigmentosa, NOS, Urticaria, ...
Urticaria Pigmentosa: The most common form of cutaneous mastocytosis (MASTOCYTOSIS, CUTANEOUS) that occurs primarily in ... Urticaria Pigmentosa. Subscribe to New Research on Urticaria Pigmentosa The most common form of cutaneous mastocytosis ( ... in the treatment of urticaria pigmentosa.". 01/01/1985 - "Ten patients with moderate to very severe urticaria pigmentosa were ... related to Urticaria Pigmentosa: 1. Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/1994 - "A case of adult-onset urticaria ...
Urticaria pigmentosa is an uncommon skin condition with reddish-brown lesions typically occurring in infants and children. In ... Urticaria pigmentosa is an uncommon skin condition marked by a rash that usually affects the neck, arms, legs and trunk of ... What causes urticaria pigmentosa?. The spots present contain a large number of mast (inflammatory) cells. Mast cells are immune ... Treating Urticaria Pigmentosa. Unfortunately for those suffering from this condition, there is no satisfactory treatment for ...
Un caso de urticaria pigmentosa identificado por mutaci n concordante; revisi n de la bibliograf a Palacios-Boix A, Garc s- ... Bone marrow findings in adult patients with urticaria pigmentosa. J Am Acad Dermatol 1988;18:45-51. ...
A case of urticaria pigmentosa with bullous lesions in a 2-year-old mile is presented. No systemic manifestation of ... Saraswat P K, Laha N N. Urticaria Pigmentosa. Indian J Dermatol Venereol Leprol 1985;51:168-169. ... Yellow urticaria in a patient with alcohol-related… March 3, 2021 *Clinical difference between single subtype and mixed… ...
Urticaria pigmentosa. Urticaria Pigmentosa. JESSIE R. MAXWELL, MD, and ABDULLA GHORI, MD. MetroHealth Medical Center, Cleveland ... of cases of childhood urticaria pigmentosa.1 Hereditary urticaria pigmentosa generally presents after 1 year of age, the ... Urticaria pigmentosa is a type of mastocytosis, a term applied to a group of disorders in which mast cells accumulate within ... Treatment of this urticaria pigmentosa generally is supportive to control the symptoms. Systemic symptoms can be relieved with ...
Urticaria pigmentosa is a skin condition that causes itching and swelling. Urticaria pigmentosa treatments are useful to get ...
Feline urticaria pigmentosa in three related sphinx cats Veterinary Dermatology 7:227-233, 1996. ...
Urticaria, commonly referred to as hives, is the most frequent dermatologic disorder seen in the emergency department (ED). It ... Urticaria pigmentosa is a familial dermatologic disorder characterized by hyperpigmented (yellow, tan, or brown) papules or ... autoimmune urticaria, urticaria multiforme, neutrophilic urticaria, cholinergic urticaria, cold urticaria, mastocytosis, Muckle ... delayed pressure urticaria, cold urticaria, and cholinergic urticaria. [13] Cold urticaria may produce severe symptoms, ...
Urticaria pigmentosa is a skin condition that causes lesions and itchy skin. This disease is most common in infants and ...
Urticaria Pigmentosa* Substances * Omalizumab ...
Urticaria pigmentosa is a skin condition that causes lesions and itchy skin. This disease is most common in infants and ...
Urticaria pigmentosa - a skin condition that causes crusty sores on the body. ...
Categories: Urticaria Pigmentosa Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Urticaria pigmentosa. Open studies. Medium- and/or high-dose. 10-15. Table 1. Main indications and recommendations for UVA1 ... Medium- versus high-dose ultraviolet A1 therapy for urticaria pigmentosa: a pilot study. J Am Acad Dermatol 2003 Oct;49(4):679- ... Four adult patients with generalized urticaria pigmentosa were treated with 130 J/cm2 UVA1 for 2 weeks. Pruritus improved after ... High-dose UVA1 for urticaria pigmentosa. Lancet 1996 Jan 6;347(8993):64. ...
Urticaria Pigmentosa : Urticaria Pigmentosa : Microscopic. Urticaria Pigmentosa : Microscopic. Urticaria Pigmentosa : ...
Adult-onset urticaria pigmentosa presents small (3-6 mm) pigmented red-brown macules and papules on the trunk and limbs ... Urticaria pigmentosa (maculopapular cutaneous mastocytosis) more commonly presents in adulthood and may be persistent and ... Maculopapular cutaneous mastocytosis (urticaria pigmentosa); red-brown maculopapular lesions on the leg ... Urticaria pigmentosa, Maculopapular cutaneous mastocytosis, Diffuse cutaneous mastocytosis, Telangiectatic cutaneous ...
Of various pathologic conditions examined, the highest binding of procollagenase occurred in specimens of urticaria pigmentosa ... Of various pathologic conditions examined, the highest binding of procollagenase occurred in specimens of urticaria pigmentosa ... Of various pathologic conditions examined, the highest binding of procollagenase occurred in specimens of urticaria pigmentosa ...
Self-Gagging, Hiccups and Yawns, Urticaria Pigmentosa - PediaCast 138. Posted by Dr. Mike on November 20, 2008. ... School Soft Contact Lenses Pediatricians Vs Family Doctors Self-Gagging 12 Month-Old Yawns and Hiccups Urticaria Pigmentosa ...
Cutaneous mastocytosis has skin lesions with typical clinical signs (i.e., urticaria pigmentosa, diffuse cutaneous mastocytosis ...
With the exception of pure cutaneous mastocytosis (usually urticaria pigmentosa), indolent SM affecting bone marrow and skin is ... Bone marrow involvement in indolent systemic mastocytosis; a 55 year old female patient with adult-type urticaria pigmentosa. ( ...
Urticaria pigmentosa presenting with massive peripheral eosinophilia. Pediatric Dermatology 14:284-286;1997. ...
Some affected individuals have a skin condition called urticaria pigmentosa (also known as maculopapular cutaneous mastocytosis ...
... whether classical urticaria pigmentosa in children or adult mastocytosis - I usually ask a directed review of systems, focusing ... When following patients with mastocytosis - whether classical urticaria pigmentosa in children or adult mastocytosis - I ...
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa ... "Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa ... "Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa ... Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa ...
Urticaria Pigmentosa. There is a long list of diseases that can make your cat itch and break out in little red bumps. Allergies ... But for your Cornish Rex, add urticaria pigmentosa to the list. The exact pathology of this itchy skin disease has not yet been ...
Urticaria Pigmentosa. There is a long list of diseases that can make your cat itch and break out in little red bumps. Allergies ... But for your Sphynx, add urticaria pigmentosa to the list. The exact pathology of this itchy skin disease has not yet been ...
  • Urticaria pigmentosa (also known as generalized eruption of cutaneous mastocytosis (childhood type): 616 ) is the most common form of cutaneous mastocytosis. (wikipedia.org)
  • Most treatments for mastocytosis can be used to treat urticaria pigmentosa. (wikipedia.org)
  • Urticaria pigmentosa is a type of mastocytosis, a term applied to a group of disorders in which mast cells accumulate within tissue. (consultant360.com)
  • The 3 major types of mastocytosis in childhood are urticaria pigmentosa, solitary mastocytoma of the skin, and diffuse cutaneous mastocytosis. (consultant360.com)
  • Systemic mastocytosis can occur in up to 2% of patients with hereditary urticaria pigmentosa and must be considered in the presence of evidence of systemic involvement such as flushing, tachycardia, hypotension, diarrhea, vomiting, symptoms of peptic ulcer, and even splenomegaly and hepatomegaly. (consultant360.com)
  • Urticaria pigmentosa is found in most patients with mastocytosis. (clinicaladvisor.com)
  • With the exception of pure cutaneous mastocytosis (usually urticaria pigmentosa), indolent SM affecting bone marrow and skin is the most common subvariant of mastocytosis. (bmj.com)
  • Some affected individuals have a skin condition called urticaria pigmentosa (also known as maculopapular cutaneous mastocytosis), which is characterized by raised patches of brownish skin that sting or itch when touched. (medlineplus.gov)
  • When following patients with mastocytosis - whether classical urticaria pigmentosa in children or adult mastocytosis - I usually ask a directed review of systems, focusing on flushing, palpitations, and gastrointestinal symptoms. (aad.org)
  • He referred me to the hospital - they did a biopsy and confirmed urticaria pigmentosa, cutaneous mastocytosis. (ukmasto.org)
  • Urticaria pigmentosa rarely progresses to systemic mastocytosis in children but may do so more often in adults. (msdmanuals.com)
  • Doctors can diagnose urticaria pigmentosa (cutaneous mastocytosis, see below) by seeing the characteristic lesions which are dark-brown and fixed. (the-medical-dictionary.com)
  • Mastocytosis represents a spectrum of disease ranging from urticaria pigmentosa, an increase of dermal mast cells, to systemic mastocytosis involving bone marrow, skeleton, gastrointestinal canal, liver and spleen. (the-medical-dictionary.com)
  • The aim of this study was to compare patients with systemic mastocytosis and with urticaria pigmentosa in regard to bone density and biochemistry. (the-medical-dictionary.com)
  • Six patients had systemic mastocytosis and ten had urticaria pigmentosa. (the-medical-dictionary.com)
  • See Systemic Mastocytosis, Mastocytosis & Urticaria Pigmentosa, and Anaphylaxis. (medscape.com)
  • The main application of urinary NMH measurement is in the diagnosis and monitoring of mast-cell disorders, such as mastocytosis (systemic and localized urticaria pigmentosa), anaphylaxis, and other severe systemic allergic reactions. (medscape.com)
  • Scholars@Duke publication: Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. (duke.edu)
  • Urticaria pigmentosa is characterized by excessive amounts of mast cells in the skin. (wikipedia.org)
  • At least one clinical study suggested that nifedipine, a calcium channel blocker used to treat high blood pressure, may reduce mast cell degranulation in patients with urticaria pigmentosa. (wikipedia.org)
  • We do not currently know why people with urticaria pigmentosa have abnormal collections of mast cells in their skin. (skinsite.com)
  • Urticaria pigmentosa is caused by mast cell hyperplasia and has been described in cats. (msdvetmanual.com)
  • More commonly, mast cells congregate in many areas of the skin, forming small reddish brown spots or bumps (called urticaria pigmentosa). (msdmanuals.com)
  • Urticaria results from the release of histamine, bradykinin, leukotriene C4, prostaglandin D2, and other vasoactive substances from mast cells and basophils in the dermis. (medscape.com)
  • If hives appear, it most likely signifies the presence of urticaria pigmentosa. (wikipedia.org)
  • Hives are medically known as urticaria, it appears on any part of the skin. (diseasesdic.com)
  • It's true Idiopathic Urticaria (the medical term for Hives) isn't usually fatal. (str8onebehealthy.com)
  • 1 Hereditary urticaria pigmentosa generally presents after 1 year of age, the lesions do not spontaneously resolve, and systemic involvement may be seen over time. (consultant360.com)
  • The lesions of IgE-mediated urticaria usually last less than 24 hours and are often migratory and leave no residual skin abnormalities. (medscape.com)
  • The amino acid sequence of human skin chymase was established by protein methods and by analysis of PCR amplification products obtained with cDNA-derived from urticaria pigmentosa (UP) lesions. (duke.edu)
  • The type III immune-complex disease is associated with systemic lupus erythematosus and other autoimmune diseases that cause urticaria. (medscape.com)
  • The intense pruritus of urticaria is a result of histamine released into the dermis. (medscape.com)
  • Based on findings from the history and physical examination, the boy received a diagnosis of urticaria pigmentosa. (consultant360.com)
  • The diagnosis of the skin disease was based on the clinical criteria for urticaria pigmentosa, e.g. multiple reddish brown maculae urticating after rubbing. (the-medical-dictionary.com)
  • The etiologies of both acute and chronic urticaria are numerous. (medscape.com)
  • The prognosis in chronic urticaria is more guarded and depends on the comorbid disease causing the urticaria, as well as on the response to therapy. (medscape.com)
  • Acute urticaria is much more common than chronic urticaria. (diseasesdic.com)
  • The prevalence rate for chronic urticaria has been estimated as 1-5 per 1,000. (diseasesdic.com)
  • Bone marrow findings in adult patients with urticaria pigmentosa. (medigraphic.com)
  • Therefore, the clinician must rule out these more severe syndromes of anaphylaxis in patients presenting with urticaria. (medscape.com)
  • In general, patients with urticaria do not require further inpatient care unless their urticaria is severe and does not respond to antihistamine therapy or unless they progress to laryngeal angioedema and/or anaphylactic shock or have comorbidities that necessitate inpatient therapy. (medscape.com)
  • Feline urticaria pigmentosa in three related sphinx cats Veterinary Dermatology 7:227-233, 1996. (omia.org)
  • Dermatology referral is mandatory if vasculitic urticaria is suspected. (medscape.com)
  • Acute IgE-mediated urticaria is the most benign form of anaphylaxis . (medscape.com)
  • Several factors can worsen the symptoms of urticaria pigmentosa:[citation needed] Emotional stress Physical stimuli such as heat, friction, and excessive exercise Bacterial toxins Venom Eye drops containing dextran NSAIDs Alcohol Morphine The classification of NSAIDs can be disputed. (wikipedia.org)
  • Treatment of this urticaria pigmentosa generally is supportive to control the symptoms. (consultant360.com)
  • Urticaria appears as raised, well-circumscribed areas of erythema and edema, often with central pallor, that involve the dermis and epidermis and are usually very pruritic. (medscape.com)
  • Urticaria pigmentosa may occur as reddish bumps on the skin. (msdmanuals.com)
  • citation needed] There are no permanent cures for urticaria pigmentosa. (wikipedia.org)
  • In many cases of urticaria it cures by its own. (diseasesdic.com)
  • An acute urticarial lesion that is healing with pigmentation raises the suspicion for urticaria pigmentosa. (consultant360.com)
  • For a general discussion of urticaria, see the overview topic Acute Urticaria . (medscape.com)
  • The prognosis in acute urticaria is excellent. (medscape.com)
  • For acute urticaria, laboratory studies generally are not indicated. (medscape.com)
  • Acute urticaria is most common in children and is more common in women than in men, particularly in the 30-60 age range. (diseasesdic.com)
  • citation needed] Urticaria pigmentosa is a rare disease, affecting fewer than 200,000 people in the United States. (wikipedia.org)
  • However, nifedipine has never been approved by the FDA for treatment of urticaria pigmentosa. (wikipedia.org)
  • Unfortunately for those suffering from this condition, there is no satisfactory treatment for urticaria pigmentosa. (skinsite.com)
  • Urticaria pigmentosa is an uncommon skin condition marked by a rash that usually affects the neck, arms, legs and trunk of children and young adults. (skinsite.com)
  • It is most common in infants, and most children who develop urticaria pigmentosa before the age of five will have resolution of the condition by adolescence or early adulthood. (skinsite.com)
  • Urticaria pigmentosa is a skin condition that causes itching and swelling. (drankireddy.com)
  • Urticaria pigmentosa - a skin condition that causes crusty sores on the body. (pdsa.org.uk)
  • 2 Tumor necrosis factor antagonists have been reported to trigger urticaria pigmentosa. (consultant360.com)
  • Urticaria pigmentosa treatments are useful to get relief. (drankireddy.com)
  • The hereditary type is rare and accounts for less than 2% of cases of childhood urticaria pigmentosa. (consultant360.com)
  • citation needed] The majority of urticaria pigmentosa cases are caused by a point mutation at amino acid 816 of the proto-oncogene c-kit. (wikipedia.org)
  • Well, this may sound revolutionary, but after my research, I came to the following conclusion: "Urticaria sufferers are not allergic to ANYTHING! (str8onebehealthy.com)
  • Certain medications can lead to worsening of urticaria pigmentosa. (consultant360.com)