Pancreatic Neoplasms
Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. (1/6661)
AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions. (+info)Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (2/6661)
AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences. (+info)Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study. (3/6661)
AIM: To evaluate the intracellular and peritumoral expression of matrix proteins in squamous cell carcinoma of the uterine cervix using immunohistochemistry. METHODS: 71 squamous cell carcinomas and 10 controls were stained for laminin, fibronectin, and collagen IV. Cytoplasmic staining in tumour cells and peritumoral deposition of matrix proteins were evaluated. The association between staining results and patient age, tumour stage, histological grade, and survival was studied. RESULTS: Positive cytoplasmic staining for laminin, fibronectin, and collagen IV was observed in 17 (23.9%), 27 (38%), and 10 (14.1%) cases, respectively. Staining for laminin was most pronounced in the invasive front of tumour islands, while for fibronectin and collagen IV it appeared to be diffuse. Peritumoral staining for laminin and collagen IV was detected in 12 cases (16.9%). Early stage (Ia1-Ia2) tumours were uniformly negative for all three proteins. Cytoplasmic staining for laminin correlated with positive staining for fibronectin and collagen IV, and with the presence of a peritumoral deposition of collagen IV and laminin. There was no correlation with any of the three markers between staining results and patient age, stage, grade, or survival. CONCLUSIONS: Expression of extracellular matrix proteins in some cervical squamous cell carcinomas might reflect the enhanced ability of these tumours to modify the peritumoral stroma. This ability seems to be absent in early stage tumours. The correlation between intracytoplasmic and peritumoral expression of matrix proteins supports the evidence of their synthesis by tumour cells. However, this property did not correlate with disease outcome in this study. (+info)Screening for cervical cancer: a review of women's attitudes, knowledge, and behaviour. (4/6661)
The United Kingdom (UK) cervical screening programme has been successful in securing participation of a high proportion of targeted women, and has seen a fall in mortality rates of those suffering from cervical cancer. There remains, however, a significant proportion of unscreened women and, of women in whom an abnormality is detected, many will not attend for colposcopy. The present work reviews the psychological consequences of receiving an abnormal cervical smear result and of secondary screening and treatment, and examines reasons for women's non-participation in the screening programme. Psychological theories of screening behavior are used to elucidate women's reactions and to suggest methods of increasing participation, of improving the quality of the service, and of reducing women's anxiety. A literature search identified studies that examine factors influencing women's participation in the screening programme, their psychological reaction to the receipt of an abnormal cervical smear result, and experiences of colposcopy. Reasons for non-participation include administrative failures, unavailability of a female screener, inconvenient clinic times, lack of awareness of the test's indications and benefits, considering oneself not to be at risk of developing cervical cancer, and fear of embarrassment, pain, or the detection of cancer. The receipt of an abnormal result and referral for colposcopy cause high levels of distress owing to limited understanding of the meaning of the smear test; many women believe the test aims to detect existing cervical cancer. The quality of the cervical screening service can be enhanced by the provision of additional information, by improved quality of communication, and by consideration of women's health beliefs. This may result in increased participation in, and satisfaction with, the service. (+info)Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. (5/6661)
Carcinoma of the uterine cervix is a common malignancy among women that has been found to show loss of heterozygosity in the chromosome 11p. Recent studies have localized the TSG101 gene in this region, and also demonstrated a high frequency of abnormalities of this gene in human breast cancer. To determine the role of the TSG101 gene in the carcinogenesis of cervical and uterine carcinoma, 19 cases of cervical carcinoma and five cases of endometrial carcinoma, as well as nearby non-cancerous tissue from the same patients, and 16 blood samples from healthy persons as normal control were analysed by Southern blot analysis of genomic DNA, reverse transcription of the TSG101 mRNA followed by PCR amplification and sequencing of the products. We found that abnormal transcripts of the TSG101 gene were common both in cancerous or non-cancerous tissues of the uterus and cervix and in normal peripheral mononuclear cells. There was no genomic deletion or rearrangement in spite of the presence of abnormal transcripts, and no definite relationship between the abnormal transcripts and HPV infection was found. Although the frequency of abnormal transcripts was higher in cancerous than in non-cancerous tissue, normal peripheral mononuclear cells also had abnormal transcripts. Given these findings, the role of the TSG101 gene as a tumour-suppressor gene should be re-evaluated. Because some aberrant transcripts could be found at the first PCR reaction, we suggest that the aberrant transcripts might be the result of imperfect minor splicesome products. (+info)A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/6661)
To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer. (+info)Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity. (7/6661)
Cervical carcinoma is an AIDS-defining illness. The expression of folate receptors (FRs) in cervical carcinoma (HeLa-IU1) cells was modulated by stable transduction of FR cDNA encapsidated in recombinant adeno-associated virus-2 in the sense and antisense orientation (sense and antisense cells, respectively). Although sense cells proliferated slower than antisense or untransduced cells in vivo and in vitro in 2% (but not 10%) FCS, [methyl-3H]thymidine incorporation into DNA was significantly increased in sense cells in 10% serum; therefore, the basis for this discrepancy was investigated. The activity of thymidine kinase (TK) was subsequently directly correlated with the extent of FR expression in single cell-derived clones of transduced cells. This elevated TK activity was not a result of recruitment of the salvage pathway based on the presence of adequate dTTP pools, normal thymidylate synthase (TS) activity, persistence of increased thymidine incorporation despite the exogenous provision of excess 5,10-methylene-tetrahydrofolate, and documentation of adequate folates in sense cells. The increase in TK activity conferred significant biological properties to sense cells (but not antisense or untransduced cells) as demonstrated by augmented phosphorylation of 3'-azido-3'-deoxythymidine (AZT) and concomitantly greater sensitivity to the cytotoxic effects of AZT. Conversely, sense cells were highly resistant to methotrexate, but this was reversed by the addition of AZT. The direct correlation of FR expression and TK activity indicates a previously unrecognized consequence of FR overexpression. (+info)Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. (8/6661)
BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (HIV). We characterized HPV infection in a large cohort of HIV-positive and HIV-negative women participating in the Women's Interagency HIV Study to determine the prevalence of and risk factors for cervicovaginal HPV infection in HIV-positive women. METHODS: HIV-positive (n = 1778) and HIV-negative (n = 500) women were tested at enrollment for the presence of HPV DNA in a cervicovaginal lavage specimen. Blood samples were tested for HIV antibody status, level of CD4-positive T cells, and HIV RNA load (copies/mL). An interview detailing risk factors was conducted. Univariate and multivariate analyses were performed. RESULTS: Compared with HIV-negative women, HIV-positive women with a CD4+ cell count of less than 200/mm3 were at the highest risk of HPV infection, regardless of HIV RNA load (odds ratio [OR] = 10.13; 95% confidence interval [CI] = 7.32-14.04), followed by women with a CD4+ count greater than 200/mm3 and an HIV RNA load greater than 20,000 copies/mL (OR = 5.78; 95% CI = 4.17-8.08) and women with a CD4+ count greater than 200/mm3 and an HIV RNA load less than 20,000 copies/mL (OR = 3.12; 95% CI = 2.36-4.12), after adjustment for other factors. Other risk factors among HIV-positive women included racial/ethnic background (African-American versus Caucasian, OR = 1.64; 95% CI = 1.19-2.28), current smoking (yes versus no; OR = 1.55; 95% CI = 1.20-1.99), and younger age (age < 30 years versus > or = 40 years; OR = 1.75; 95% CI = 1.23-2.49). CONCLUSIONS: Although the strongest risk factors of HPV infection among HIV-positive women were indicators of more advanced HIV-related disease, other factors commonly found in studies of HIV-negative women, including racial/ethnic background, current smoking, and age, were important in HIV-positive women as well. (+info)Uterine cervical neoplasms, also known as cervical cancer or cervical dysplasia, refer to abnormal growths or lesions on the lining of the cervix that have the potential to become cancerous. These growths are usually caused by human papillomavirus (HPV) infection and can be detected through routine Pap smears.
Cervical neoplasms are classified into different grades based on their level of severity, ranging from mild dysplasia (CIN I) to severe dysplasia or carcinoma in situ (CIN III). In some cases, cervical neoplasms may progress to invasive cancer if left untreated.
Risk factors for developing cervical neoplasms include early sexual activity, multiple sexual partners, smoking, and a weakened immune system. Regular Pap smears and HPV testing are recommended for early detection and prevention of cervical cancer.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
Murine respirovirus
P16
Urogenital neoplasm
MORT (long non-coding RNA)
Florid cutaneous papillomatosis
Hematometra
Adolf Gusserow
Adenosarcoma
Cervical cancer
Dyskaryosis
List of MeSH codes (C13)
Glassy cell carcinoma of the cervix
List of cancer types
Mixed Müllerian tumor
Obstetrical bleeding
Carcinoma in situ
MAGEA4
List of MeSH codes (C04)
Polyp (medicine)
Small-cell carcinoma
List of skin conditions
Uterus
Fibroblast activation protein, alpha
Brachytherapy
Glossary of medicine
Ovarian cancer
Estrogen (medication)
Interventional radiology
Hysterectomy
Uterine fibroid
Uterine Cervical Neoplasms - Medical Dictionary online-medical-dictionary.org
Uterine Cervical Neoplasms | Profiles RNS
Results of search for 'su:{Uterine cervical neoplasms}' › WHO HQ Library catalog
Cervical Cancer | HPV | Human Papillomavirus | MedlinePlus
Cervical cancer and use of hormonal contraceptives: a systematic review
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Cervical Cancer Imaging: Practice Essentials, Computed Tomography (CT), Magnetic Resonance Imaging (MRI)
Cost-effectiveness of HPV vaccination in the context of high cervical cancer incidence and low screening coverage
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De novo establishment and cost-effectiveness of Papanicolaou cytology screening services in the Socialist Republic of Vietnam.
Knowledge and practice of women regarding cervical cancer in a primary health care unit
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Prediction of lymphovascular space invasion in patients with endometrial cancer
Cervix1
- Two epidemiological studies [ref: 1,2] of women treated with metronidazole showed some excesses of cancers of the uterine cervix, a neoplasm that has risk factors in common with vaginal trichomoniasis, the main indication in women for treatment with this drug. (inchem.org)
Metastasis1
- Moreover, cervical cancer HeLa cells overexpressing miR-215 (HeLa-miR-215) were constructed and subcutaneously injected into the nude mice to examine the effect of miR-215 on tumor growth and metastasis in vivo. (nih.gov)
Carcinoma3
- A multicenter phase 2 trial of camrelizumab plus famitinib for women with recurrent or metastatic cervical squamous cell carcinoma. (nih.gov)
- Significant residual disease was defined as HGSIL or cervical carcinoma. (medscape.com)
- The link between squamous cell cervical carcinoma and human papillomavirus (HPV) 16/18 is well established, but the magnitude of the risk association is uncertain and the importance of other high-risk HPV (HRHPV) types is unclear. (chalmers.se)
Dysplasia3
- OBJECTIVE: Many patients undergo hysterectomy for the treatment of cervical dysplasia. (medscape.com)
- We set out to determine preoperative features that may predict residual disease for patients treated for cervical dysplasia. (medscape.com)
- Cervical Dysplasia: Is It Cancer? (nih.gov)
Intraepithelial Neoplasia1
- METHODS: We compared HPV testing, using an assay approved by the Food and Drug Administration, with conventional Pap testing as a screening method to identify high-grade cervical intraepithelial neoplasia in women ages 30 to 69 years in Montreal and St. John's, Canada. (mcmaster.ca)
Hysterectomy2
- Simple Hysterectomy for Residual Cervical Intraepithelial Neoplasm. (medscape.com)
- For women with FIGO stage IB3-IVA cervical cancer, a planned adjuvant hysterectomy after RT or chemoradiation is not recommended. (guidelinecentral.com)
Prevention4
- 8. Annual national direct and indirect cost estimates of the prevention and treatment of cervical cancer in Brazil. (nih.gov)
- 16. [Awareness of cervical cancer prevention among patients of gynecological outpatient clinic]. (nih.gov)
- 18. Determining costs of health care services for cost-effectiveness analyses: the case of cervical cancer prevention and treatment. (nih.gov)
- We then provide a case study from our own research using a CBPR approach to examine beliefs and attitudes about cervical cancer prevention among Oregon Latinos. (pdx.edu)
Locally advanced cervical cancer2
- The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer. (msdoncologyclinicaltrials.com)
- This prospective, phase 2 study aimed at assessing the efficacy of accelerated fractionation radiation therapy by concomitant boosts (CBs) associated with chemoradiation therapy (CRT) of the whole pelvis, in improving the rate of pathological complete response (pCR) to treatment in patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IB2-IVA locally advanced cervical cancer. (unicatt.it)
High-grade cervical1
- Loss of KAI1 expression was also found in a subset of 10 high-grade cervical dysplasias. (duke.edu)
Vaccination1
- Impact of HPV vaccination on HPV infection and cervical related disease burden in real-world settings (HPV-RWS): protocol of a prospective cohort. (nih.gov)
Recurrence2
- It was concluded that the expression level of miR-215 is associated with cervical tumor progression and worse survival rate, suggesting that it may serve as a potential prognostic marker to identify patients at higher risk of recurrence. (nih.gov)
- For women with cervical cancer and intermediate-risk factors, adjuvant EBRT is recommended to decrease locoregional recurrence. (guidelinecentral.com)
Tumor1
- The paraffin-embedded paired cervical scrape samples and tumor tissue samples from 302 patients with stage II cervical cancer were detected for the expression of miR-215 by using qRT-PCR. (nih.gov)
Cancers2
- Cancers associés aux virus en Afrique. (who.int)
- While chronic myeloproliferative neoplasms are rare cancers of the blood, it can be difficult to diagnose. (psychokinesis.co.il)
Radiation1
- For women with cervical cancer receiving postoperative whole pelvis radiation, a brachytherapy boost is conditionally recommended in the presence of positive margin(s). (guidelinecentral.com)
Progression-free sur1
- The primary hypothesis is that pembrolizumab/vibostolimab co-formulation is superior to pembrolizumab alone in terms of objective response rate or progression-free survival in participants with cervical cancer. (msdoncologyclinicaltrials.com)
Infections4
- Particular states of the cervicovaginal microbiota and viral infections are associated with increased cervical cancer risk. (nebraska.edu)
- To better understand and address cervical cancer in sub-Saharan Africa, a better knowledge of the regional cervicovaginal microbiome is required This review establishes current knowledge of HPV, HIV, cervicovaginal infections, and the cervicovaginal microbiota in sub-Saharan Africa. (nebraska.edu)
- In addition to high prevalence and diversity of HIV and HPV, intracellular bacterial infections such as Chlamydia, Gonorrhea, and Mycoplasma hominis are much more common than in regions with a low burden of cervical cancer. (nebraska.edu)
- In addition to chronic fatigue, people with chronic myeloproliferative neoplasms may experience bleeding, anemia, or infections. (psychokinesis.co.il)
Invasiveness1
- The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. (geneticsmr.com)
Sexual behavior1
- Because the population of women undergoing cervical cancer screening is heterogeneous with respect to sexual behavior, and therefore risk of HPV acquisition and subsequent precancers, we use a mover-stayer mixture model that assumes a proportion of the population will stay in the healthy state and are not subject to disease progression. (nih.gov)
Screening13
- Cervical screening : a practical guide / Ann McPherson. (who.int)
- Cervical cancer screening programmes : managerial guidelines. (who.int)
- Cytological screening in the control of cervical cancer : technical guidelines. (who.int)
- 2. [Costs of population cervical cancer screening program in Poland between 2007-2009]. (nih.gov)
- 6. ["Cost-effectiveness" of cervical screening]. (nih.gov)
- 11. [Cost effectiveness analysis of screening strategies for cervical cancer in Tunisia]. (nih.gov)
- 13. Modeling cost-effectiveness of cervical cancer screening in Hungary. (nih.gov)
- Objective There is a shortage of trained health care personnel for cervical cancer screening in low-/middle-income countries. (nyu.edu)
- Conclusions Our findings demonstrate the feasibility and efficacy of mHealth-supported VIA training of CHNs and have the potential to improve cervical cancer screening coverage in Ghana. (nyu.edu)
- Background: Latina immigrants from Mexico suffer significantly increased morbidity and mortality from cervical cancer when compared with non-Hispanic White women, largely owing to lack of screening and appropriate treatment. (pdx.edu)
- Methods in that study included extensive discussions with our community advisory board (CAB) and promotores (community health workers) regarding barriers to cervical cancer screening for Latinas and community health concerns in general, and in-depth interviews with more than 50 Latino immigrants. (pdx.edu)
- We illustrate their application for the design of a primary screening trial comparing human papillomavirus DNA testing versus cervical screening (by Pap smear). (mcmaster.ca)
- BACKGROUND: To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods. (mcmaster.ca)
Endometrium1
- Under the influence of estrogen the endometrium (uterine lining) is stimulated and eventually such lining will be shed off (estrogen breakthrough bleeding). (bionity.com)
Vaginal1
- 9. Cervical, Vaginal, and Vulvar Cancer Costs Incurred by the Medicaid Program in Publicly Insured Patients in Texas. (nih.gov)
Polyps1
- Polyps of the uterine lining are a common cause of bleeding, but such bleeding tends to be light. (bionity.com)
Fibroids1
- Uterine fibroids represent a common, benign condition that may lead to bleeding, specifically if the lesion affects the uterine cavity. (bionity.com)
Inflammation2
- Microbiota associated with cervical inflammation have been found to be especially prevalent in sub-Saharan Africa, and to associate with increased cervical cancer risk. (nebraska.edu)
- This suggests the prevalence of cervical cancer in sub-Saharan Africa may be partially attributed to increased cervical inflammation resulting from higher likelihood of cervical infection and/or microbial dysbiosis. (nebraska.edu)
Risk Factors1
- For women undergoing surgery for cervical cancer who have high surgicopathologic risk factors, adjuvant EBRT and concurrent platinum-based chemotherapy are recommended. (guidelinecentral.com)
Burden1
- Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. (nebraska.edu)
Abnormal1
- 15. Management of women with abnormal cervical cytology: treatment patterns and associated costs in England and Wales. (nih.gov)
Obstetrics1
- Neoadjuvant chemotherapy for patients with international federation of gynecology and obstetrics stages IB3 and IIA2 cervical cancer: a multicenter prospective trial. (nih.gov)
Women12
- This research assessed the role of having a coherent explanation of the link between smoking and cervical cancer in motivating women to stop smoking. (nih.gov)
- In a cross-sectional analysis, having a coherent explanation moderated the relationship between perceived vulnerability and intention: Higher perceived vulnerability to cervical cancer was associated with greater intention to quit smoking only amongst women with a more coherent explanation of the link between smoking and cervical cancer. (nih.gov)
- In women with cervical cancer treated with postoperative RT with or without chemotherapy, IMRT is recommended to decrease acute and chronic toxicity. (guidelinecentral.com)
- For women receiving definitive RT for intact cervical cancer, brachytherapy is recommended. (guidelinecentral.com)
- For women receiving brachytherapy for cervical cancer, intra-procedure imaging is recommended if available. (guidelinecentral.com)
- For women receiving brachytherapy for cervical cancer, MRI or CT-based planning to a volume-based prescription is recommended. (guidelinecentral.com)
- For women receiving brachytherapy for cervical cancer, if volume-based planning cannot be performed, then 2-D/point-based planning is recommended. (guidelinecentral.com)
- For women treated with definitive RT for cervical cancer, the total EQD2 10 of EBRT and brachytherapy should be ≥8000 cGy. (guidelinecentral.com)
- For women with cervical cancer receiving volume-based brachytherapy, HR-CTV D90 greater than or equal to prescription dose (≥8000 cGy) is conditionally recommended, with careful consideration of normal tissue constraints. (guidelinecentral.com)
- In women treated with brachytherapy for intact cervical cancer, volumetric contouring of the OARs and use of appropriate dose constraints are recommended. (guidelinecentral.com)
- If volumetric planning is not available for women treated with brachytherapy for intact cervical cancer, 2-D/point-based dose constraints should be applied. (guidelinecentral.com)
- In one study [ref: 1], a greater excess of cervical cancer was observed in women with trichomoniasis who were not exposed to metronidazole than in those who were (relative risk, 2.1 versus 1.7). (inchem.org)
Human1
- We introduce a discrete time HMM for human papillomavirus (HPV) and cervical precancer/cancer where the hidden and observed state spaces are defined by all possible combinations of HPV, cytology, and colposcopy results. (nih.gov)