Vasoplegia
A retrospective analysis of terlipressin in bolus for the management of refractory vasoplegic hypotension after cardiac surgery. (1/7)
(+info)Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties. (2/7)
(+info)Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind randomized study. (3/7)
(+info)Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients. (4/7)
(+info)Post cardiac surgery vasoplegia is associated with high preoperative copeptin plasma concentration. (5/7)
(+info)Guanylate cyclase inhibition by methylene blue as an option in the treatment of vasoplegia after a severe burn. A medical hypothesis. (6/7)
Today it is known that severe burns can be accompanied by the phenomenon of vasoplegic syndrome (VS), which is manifested by persistent and diffuse vasodilation, hypotension and low vascular resistance, resulting in circulatory and respiratory failure. The decrease in systemic vascular resistance observed in VS is associated with excessive production of nitric oxide (NO). In the last 2 decades, studies have reported promising results from the administration of an NO competitor, methylene blue (MB), which is an inhibitor of the soluble guanylate cyclase (sGC), in the treatment of refractory cases of vasoplegia. This medical hypothesis rationale is focused on the tripod of burns/vasoplegia catecholamine resistant/methylene blue. This article has 3 main objectives: 1) to study the guanylate cyclase inhibition by MB in burns; 2) to suggest MB as a viable, safe and useful co-adjuvant therapeutic tool of fluid resuscitation, and; 3) to suggest MB as burns hypotensive vasoplegia amine-resistant treatment.(+info)
Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery. (7/7)
(+info)Vasoplegia is a medical condition characterized by profound, persistent, and often diffuse vasodilation of the systemic arterial circulation. This results in a significant decrease in systemic vascular resistance and can lead to severe hypotension that is unresponsive to fluid resuscitation and requires the use of vasopressors to maintain adequate blood pressure. Vasoplegia is often seen in critically ill patients, such as those undergoing cardiac surgery or experiencing septic shock. It can also be associated with other conditions like anaphylaxis, liver transplantation, and neuroinflammation.
Arterial pressure is the pressure exerted by the blood on the walls of the arteries during its flow through them. It is usually measured in millimeters of mercury (mmHg) and is expressed as two numbers: systolic and diastolic pressures. Systolic pressure is the higher value, representing the pressure when the heart contracts and pushes blood into the arteries. Diastolic pressure is the lower value, representing the pressure when the heart relaxes and fills with blood. A normal resting blood pressure for adults is typically around 120/80 mmHg.
Methylene blue
Vasoplegic syndrome
Vasodilatory shock
Septic shock
Vasoplegia - Medical Dictionary online-medical-dictionary.org
Blocking soluble guanylate cyclase could be the present and future of NO/cGMP inhibition for vasoplegia treatment | Critical...
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Refractory3
- Effective therapeutic options for vasopressor-refractory vasoplegia are limited. (neilriordanivc.com)
- We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. (neilriordanivc.com)
- Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. (umn.edu)
CARDIOPULMONARY BYPASS3
- Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series. (neilriordanivc.com)
- Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. (neilriordanivc.com)
- Most of the research on the use of MB has been in patients with vasoplegia following cardiopulmonary bypass. (rebelem.com)
Cardiac4
- Nitrate induced vasoplegia depletes cardiac energy reserves: a model for acute cardiomyopathy in septic shock? (ox.ac.uk)
- Cardiac vasoplegia is a common complication after cardiac surgery. (neilriordanivc.com)
- Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies. (neilriordanivc.com)
- Many children develop shock mimicking toxic shock syndrome, with vasoplegia and cardiac dysfunction as prominent features. (nomisfoundation.ch)
Methylene1
- I have used methylene blue occasionally for post-CPB vasoplegia, but would it work in septic shock? (eddyjoemd.com)
20181
- 2018. Vasoplegia After Cardiovascular Procedures-Pathophysiology and Targeted Therapy. . (cornell.edu)
Therapeutic1
- As pulmonary compliance appears relatively preserved during the early stages of coronavirus disease 2019 (COVID-19), a role for right-to-left shunting due to pulmonary vasoplegia has been hypothesized, suggesting a possible therapeutic benefit from inhaled pulmonary vasodilators [ 1 ] including milrinone, nitric oxide, and cyclic prostaglandins (e.g., iloprost). (accjournal.org)
Surgery1
- Vasoplegia that develops during or post surgery (e.g. (online-medical-dictionary.org)
Common1
- The most common side effect is vasoplegia. (blogspot.com)
Treatment1
- Cumulative evidence indicates that NO/cGMP inhibition would make a difference in vasoplegia treatment. (biomedcentral.com)
Present1
- The ensuing vasoplegia, coagulopathy, and depressed myocardial function present numerous challenges during the weaning process, as well as during the following hours in the intensive care unit (ICU). (medscape.com)
SEPTIC SHOCK3
- Nitrate induced vasoplegia depletes cardiac energy reserves: a model for acute cardiomyopathy in septic shock? (escardio.org)
- I have used methylene blue occasionally for post-CPB vasoplegia, but would it work in septic shock? (eddyjoemd.com)
- Although methylene blue is often used to treat vasoplegia associated with cardiopulmonary bypass, only two randomized clinical trials performed more than 20 years ago have addressed the use of methylene blue in patients with septic shock , said Nuria Ayala Delgadillo, MD, in a presentation at the Society of Critical Care Medicine's (SCCM) 2023 Critical Care Congress . (medscape.com)
Cardiopulmonary1
- In this case, we managed vasoplegia by maintaining high flows of the cardiopulmonary bypass, reducing the use of volatile anesthetics, administering vasoactive drugs, and optimizing hemoglobin levels above normal thresholds. (brieflands.com)
Shock2
- However, in the pediatric population, there are few case reports and only one controlled study on administration of MB use for vasoplegia, sepsis, or shock in general. (ima.org.il)
- Afección en la que se encuentra baja RESISTENCIA VASCULAR sistémica secundaria a otras afecciones tales como ANAFILAXIA, SEPSIS, SHOCK QUIRÚRGICO y SHOCK SÉPTICO. (bvsalud.org)
Therapy2
- While norepinephrine is confirmed as first line therapy for the treatment of vasoplegia, the latest Surviving Sepsis Campaign guidelines also consider that the best therapeutic management of vascular hyporesponsiveness to vasopressors could be a combination of multiple vasopressors, including norepinephrine and early prescription of vasopressin. (medscape.com)
- 2018. Vasoplegia After Cardiovascular Procedures-Pathophysiology and Targeted Therapy. . (cornell.edu)
Present1
- The ensuing vasoplegia, coagulopathy, and depressed myocardial function present numerous challenges during the weaning process, as well as during the following hours in the intensive care unit (ICU). (medscape.com)