A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)
A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.
An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.
Ocular disorders attendant upon non-ocular disease or injury.
A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)
General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.
A nutritional condition produced by a deficiency of VITAMIN A in the diet, characterized by NIGHT BLINDNESS and other ocular manifestations such as dryness of the conjunctiva and later of the cornea (XEROPHTHALMIA). Vitamin A deficiency is a very common problem worldwide, particularly in developing countries as a consequence of famine or shortages of vitamin A-rich foods. In the United States it is found among the urban poor, the elderly, alcoholics, and patients with malabsorption. (From Cecil Textbook of Medicine, 19th ed, p1179)
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)
Hemorrhage caused by vitamin K deficiency.
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.
Oil obtained from the seeds of Gossypium herbaceum L., the cotton plant. It is used in dietary products such as oleomargarine and many cooking oils. Cottonseed oil is commonly used in soaps and cosmetics.
A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.
The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.
Usually refers to planned scientific data-gathering excursions.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The prevailing temper or spirit of an individual or group in relation to the tasks or functions which are expected.
'Medical manuscripts' are written documents that present original research, review articles, case studies, or theoretical discussions in the field of medicine, prepared following specific guidelines and structures for scientific communication, intended for publication in peer-reviewed medical journals.
Traditional Arabic methods used in medicine in the ARAB WORLD.
Time period from 1601 through 1700 of the common era.

Effect of vitamin E in gastric mucosal injury induced by ischaemia-reperfusion in nitric oxide-depleted rats. (1/352)

BACKGROUND: Neutrophil infiltration and lipid peroxide accumulation are involved in reperfusion-induced gastric mucosal injury in nitric oxide-depleted rats. AIM: To assess the effect of vitamin E on this injury. METHODS: After ischaemia-reperfusion, the total area of erosions, lipid peroxide contents in gastric mucosa, and gastric neutrophil accumulation were compared between nitric oxide-depleted rats with deficient, normal, and increased vitamin E intake over 8 weeks. Thiobarbituric acid-reactive substances and tissue-associated myeloperoxidase activity were measured in gastric mucosa as indices of lipid peroxidation and neutrophil infiltration. RESULTS: The total area of erosions was significantly increased in the vitamin E-deficient group compared with the sufficient-intake and vitamin-supplemented groups. Both thiobarbituric acid-reactive substances and myeloperoxidase activity also were significantly increased in the vitamin E-deficient group compared with others. The total area of erosions closely paralleled the increases in both thiobarbituric acid-reactive substances and myeloperoxidase activity. CONCLUSION: These results indicate that the inhibition of lipid peroxidation and interference with neutrophil infiltration by vitamin E may be responsible for its cytoprotective effect in ischaemia-reperfusion.  (+info)

Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. (2/352)

BACKGROUND: Type 1 brittle asthma is a rare form of asthma. Atopy, psychosocial factors and diet may contribute to this condition. As increased dietary magnesium has a beneficial effect on lung function and selenium, vitamins A, C and E have antioxidant properties, a study was undertaken to test the hypothesis that patients with brittle asthma have diets deficient in these nutrients compared with subjects with non-brittle asthma and healthy adults. METHODS: A case control study of the dietary intakes of 20 subjects with brittle asthma, 20 with non-brittle asthma, and 20 healthy adults was performed using five day weighed dietary records. Intake of magnesium was the primary outcome measure with selenium and vitamins A, C and E as secondary outcomes. Serum levels were measured at the same time as the dietary assessment. RESULTS: Sixty subjects (27 men) of mean age 49.5 years were recruited and completed the study. Subjects with brittle asthma had statistically lower median dietary intakes of vitamins A and E than the other groups (vitamin A: brittle asthma 522.5 micrograms/day, non-brittle asthma 869.5 micrograms/day, healthy adults 806.5 micrograms/day; vitamin E: brittle asthma 4.3 mg/day, non-brittle asthma 4.6 mg/day, healthy adults 4.5 mg/day). Median dietary intakes for the other nutrients were not significantly different between groups. Serum levels were within normal ranges for each nutrient in all subjects. Intakes less than the reference nutrient intake (RNI) for magnesium and vitamins A and C, and less than the safe intake (SI) for vitamin E were more likely in patients with brittle asthma than in those with non-brittle asthma. CONCLUSION: Nutrient deficiency and reduced antioxidant activity may contribute to disease activity in type 1 brittle asthma, although a prospective study of replacement therapy will be needed to confirm this hypothesis.  (+info)

Postnatal proliferation of DRG non-neuronal cells in vitamin E-deficient rats. (3/352)

Changes in the number of satellite cells in neuron body sheaths in dorsal root ganglia (DRGs) were studied from 1 to 5 months of age in control and in vitamin E-deficient rats; furthermore, the satellite cell proliferation rate was detected in the same groups of animals with immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU). The number of satellite cells in sheaths of DRG neurons increased in the period of life considered both in control and in vitamin E-deficient rats. Satellite cell proliferation was observed in both groups, but its rate was found to be higher in vitamin E-deficient rats. The results obtained in control rats confirm that mitotic ability is retained by satellite cells in adulthood and show that at least some of newborn satellite cells add to the pre-existing population. The results obtained in vitamin E-deficient rats suggest that a faster turnover in satellite cell population takes place in these animals and support the idea that vitamin E could be an exogenous factor controlling cell proliferation.  (+info)

Ozone potentiates vitamin E depletion by ultraviolet radiation in the murine stratum corneum. (4/352)

As the outermost layer of the skin, the stratum corneum is exposed to environmental oxidants. To investigate putative synergisms of environmental oxidative stressors in stratum corneum, hairless mice were exposed to ultraviolet radiation (UV) and ozone (O(3)) alone and in combination. Whereas a significant depletion of alpha-tocopherol was observed after individual exposure to either a 0.5 minimal erythemal dose of UV or 1 ppm O(3) for 2 h, the combination did not increase the effect of UV alone. However, a dose of 0.5 ppm O(3) x 2 h, which had no effect when used alone, significantly enhanced the UV-induced depletion of vitamin E. We conclude that concomitant exposure to low doses of UV and O(3) at levels near those that humans can be exposed to causes additive oxidative stress in the stratum corneum.  (+info)

Dietary selenium and vitamin E intakes alter beta-adrenergic response of L-type Ca-current and beta-adrenoceptor-adenylate cyclase coupling in rat heart. (5/352)

Previously we have shown that both insufficient (combined with vitamin E deficiency) and excess intake of selenium (Se) impairs isoproterenol (ISO)-induced contractions of rat papillary muscle. In the present study, we used patch-clamp and biochemical techniques to investigate mechanisms of this effect in rats fed a Se- and vitamin E-deficient, a Se-excess or a normal diet. Whole-cell configuration of patch-clamp technique was used to investigate L-type Ca(2+) currents (I(Ca,L)) and their regulation by beta-adrenergic receptor stimulation in enzymatically isolated single rat ventricular myocytes. Alteration of Se and vitamin E intake did not affect peak I(Ca,L), but the threshold potential of activation was significantly different among groups. Maximal I(Ca,L) responses to ISO were depressed in both experimental groups, but the EC(50) values were not affected. In the Se-deficient group, basal, ISO- or forskolin-induced adenylate cyclase (AC) activity, measured in cardiac membrane preparations, was reduced when compared to the control, whereas 5' guanylyimidodphosphate (GppNHp) stimulated activity was unaffected. Decreased beta-adrenoceptor density and reduced GppNHp-induced affinity shift in ISO binding were also observed in the deficient group. No such differences were present in the excess group. These results suggest that combined Se and vitamin E deficiency interferes with beta-adrenoceptor-AC coupling, whereas excess intake of Se does not affect it. Thus, in the deficient group, the impairment of I(Ca) responses to ISO may be a result of a defect in beta-adrenoceptor-AC pathway. Impairment of I(Ca) response in the excess group, however, appears to have a different underlying mechanism.  (+info)

Selenium and viral virulence. (6/352)

A mouse model of coxsackievirus-induced myocarditis is being used to investigate nutritional determinants of viral virulence. This approach was suggested by research carried out in China which showed that mice fed diets composed of low selenium ingredients from a Keshan disease area suffered more extensive heart damage when infected with a coxsackie B4 virus than infected mice fed the same diet but supplemented with selenium by esophageal intubation. Selenium deficiency in our mice increased the virulence of an already virulent strain of coxsackievirus B3 (CVB3/20) and also allowed conversion of a non-virulent strain (CVB3/0) to virulence. Such conversion of CVB3/0 was accompanied by a change in the viral genome to more closely match that of the virulent virus, CVB3/20. As far as the authors are aware, this is the first report of host nutrition influencing the genetic make-up of an invading pathogen. Nutritionists may need to consider this mechanism of increased viral virulence in order to gain a better understanding of diet/infection relationships.  (+info)

Regulation of manganese superoxide dismutase (MnSOD) in chronic experimental alcoholism: effects of vitamin E-supplemented and -deficient diets. (7/352)

In order to investigate the pathogenic mechanism responsible for liver injury associated with chronic alcoholism, we studied the effects of different dietary vitamin E levels in chronically ethanol (EtOH)-fed rats on the activity and mRNA regulation of the manganese superoxide dismutase (MnSOD) enzyme. Evidence is accumulating that intermediates of oxygen reduction may in fact be associated with the development of alcoholic liver disease. Since low vitamin E liver content seems to potentiate EtOH-linked oxidative stress, we studied the effect of EtOH treatment in livers from rats fed a diet deficient or supplemented with vitamin E. Chronic EtOH feeding enhanced hepatic consumption of vitamin E in both groups of EtOH-treated animals, irrespectively of the vitamin E level of the basal diet and the effect was observed in both the microsomal and mitochondrial fractions. Both EtOH-fed groups exhibited increased MnSOD gene expression, while the enzyme activity was enhanced only in the vitamin E-deprived group of EtOH-treated animals. The significant increase in manganese liver content found only in this last group could explain the rise of enzyme activity. In fact, in the absence of a parallel increase of the prosthetic ion manganese, MnSOD mRNA induction was not accompanied by a higher enzymatic activity. These findings support the role of oxidative alteration in the EtOH-induced chronic hepatotoxicity in which MnSOD response might represent a primary defence mechanism against the damaging effect of oxygen radical species.  (+info)

Lack of hemoglobin response to iron supplementation in anemic mexican preschoolers with multiple micronutrient deficiencies. (8/352)

BACKGROUND: In developing countries, incomplete resolution of anemia with iron supplementation is often attributed to poor compliance or inadequate duration of supplementation, but it could result from deficiencies of other micronutrients. OBJECTIVE: Our objective was to assess children's hematologic response to supervised, long-term iron supplementation and the relation of this response to other micronutrient deficiencies, anthropometry, morbidity, and usual dietary intake. DESIGN: Rural Mexican children aged 18-36 mo (n = 219) were supplemented for 12 mo with either 20 mg Fe, 20 mg Zn, both iron and zinc, or placebo. Children were categorized as iron-unsupplemented (IUS; n = 109) or iron supplemented (IS; n = 108). Hemoglobin, hematocrit, mean corpuscular volume, mean cell hemoglobin, plasma concentrations of micronutrients that can affect hematopoiesis, anthropometry, and diet were assessed at 0, 6, and 12 mo; morbidity was assessed biweekly. RESULTS: At baseline, 70% of children had low hemoglobin (+info)

Vitamin E deficiency is a condition that occurs when there is a lack of sufficient vitamin E in the body. Vitamin E is a fat-soluble antioxidant that plays an essential role in maintaining the health of cell membranes, protecting them from damage caused by free radicals. It also helps to support the immune system and promotes healthy blood vessels and nerves.

Vitamin E deficiency can occur due to several reasons, including malnutrition, malabsorption disorders such as cystic fibrosis or celiac disease, premature birth, or genetic defects affecting the alpha-tocopherol transfer protein (alpha-TTP), which is responsible for transporting vitamin E from the liver to other tissues.

Symptoms of vitamin E deficiency may include:

* Neurological problems such as peripheral neuropathy, ataxia (loss of coordination), and muscle weakness
* Retinopathy (damage to the retina) leading to vision loss
* Increased susceptibility to oxidative stress and inflammation
* Impaired immune function

Vitamin E deficiency is rare in healthy individuals who consume a balanced diet, but it can occur in people with certain medical conditions or those who have undergone bariatric surgery. In these cases, supplementation may be necessary to prevent or treat vitamin E deficiency.

Medical Definition of Vitamin E:

Vitamin E is a fat-soluble antioxidant that plays a crucial role in protecting your body's cells from damage caused by free radicals, which are unstable molecules produced when your body breaks down food or is exposed to environmental toxins like cigarette smoke and radiation. Vitamin E is also involved in immune function, DNA repair, and other metabolic processes.

It is a collective name for a group of eight fat-soluble compounds that include four tocopherols and four tocotrienols. Alpha-tocopherol is the most biologically active form of vitamin E in humans and is the one most commonly found in supplements.

Vitamin E deficiency is rare but can occur in people with certain genetic disorders or who cannot absorb fat properly. Symptoms of deficiency include nerve and muscle damage, loss of feeling in the arms and legs, muscle weakness, and vision problems.

Food sources of vitamin E include vegetable oils (such as sunflower, safflower, and wheat germ oil), nuts and seeds (like almonds, peanuts, and sunflower seeds), and fortified foods (such as cereals and some fruit juices).

Ataxia is a medical term that refers to a group of disorders affecting coordination, balance, and speech. It is characterized by a lack of muscle control during voluntary movements, causing unsteady or awkward movements, and often accompanied by tremors. Ataxia can affect various parts of the body, such as the limbs, trunk, eyes, and speech muscles. The condition can be congenital or acquired, and it can result from damage to the cerebellum, spinal cord, or sensory nerves. There are several types of ataxia, including hereditary ataxias, degenerative ataxias, cerebellar ataxias, and acquired ataxias, each with its own specific causes, symptoms, and prognosis. Treatment for ataxia typically focuses on managing symptoms and improving quality of life, as there is no cure for most forms of the disorder.

Encephalomalacia is a medical term that refers to the softening and degeneration of brain tissue. It is typically caused by an injury, infection, or lack of oxygen supply to the brain. This condition can lead to various neurological symptoms depending on the location and extent of the damage in the brain. Encephalomalacia may result in cognitive impairments, motor function loss, speech difficulties, and other long-term disabilities. Treatment options vary based on the underlying cause and severity of the condition but often include rehabilitation therapies to help manage symptoms and improve quality of life.

Alpha-tocopherol is the most active form of vitamin E in humans and is a fat-soluble antioxidant that helps protect cells from damage caused by free radicals. It plays a role in immune function, cell signaling, and metabolic processes. Alpha-tocopherol is found naturally in foods such as nuts, seeds, leafy green vegetables, and vegetable oils, and it is also available as a dietary supplement.

Selenium is a trace element that is essential for the proper functioning of the human body. According to the medical definitions provided by the National Institutes of Health (NIH), selenium is a component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defense systems, and immune function.

Selenium is found in a variety of foods, including nuts (particularly Brazil nuts), cereals, fish, and meat. It exists in several forms, with selenomethionine being the most common form found in food. Other forms include selenocysteine, which is incorporated into proteins, and selenite and selenate, which are inorganic forms of selenium.

The recommended dietary allowance (RDA) for selenium is 55 micrograms per day for adults. While selenium deficiency is rare, chronic selenium deficiency can lead to conditions such as Keshan disease, a type of cardiomyopathy, and Kaschin-Beck disease, which affects the bones and joints.

It's important to note that while selenium is essential for health, excessive intake can be harmful. High levels of selenium can cause symptoms such as nausea, vomiting, hair loss, and neurological damage. The tolerable upper intake level (UL) for selenium is 400 micrograms per day for adults.

Eye manifestations refer to any changes or abnormalities in the eye that can be observed or detected. These manifestations can be related to various medical conditions, diseases, or disorders affecting the eye or other parts of the body. They can include structural changes, such as swelling or bulging of the eye, as well as functional changes, such as impaired vision or sensitivity to light. Examples of eye manifestations include cataracts, glaucoma, diabetic retinopathy, macular degeneration, and uveitis.

Congenital cortical hyperostosis is a rare, inherited bone disorder that is characterized by abnormal thickening of the outer layer of bones (cortical hyperostosis). This condition primarily affects the skull and long bones of the arms and legs. The exact cause of congenital cortical hyperostosis is not fully understood, but it is believed to be related to mutations in certain genes that regulate bone growth and development.

The symptoms of congenital cortical hyperostosis can vary widely from person to person, depending on the severity and location of the bone abnormalities. Some common features of this condition include:

* A thickened skull, which may cause a prominent forehead or a misshapen head
* Abnormally thick and dense long bones in the arms and legs, which can make them heavy and difficult to move
* Delayed growth and development
* Increased risk of fractures
* Pain and stiffness in the affected bones

Congenital cortical hyperostosis is typically diagnosed based on a combination of clinical symptoms, imaging studies (such as X-rays or CT scans), and genetic testing. There is no cure for this condition, but treatment may involve pain management, physical therapy, and surgery to correct any bone deformities. In some cases, the symptoms of congenital cortical hyperostosis may improve over time, but in others, they may persist throughout life.

Malabsorption syndromes refer to a group of disorders in which the small intestine is unable to properly absorb nutrients from food, leading to various gastrointestinal and systemic symptoms. This can result from a variety of underlying conditions, including:

1. Mucosal damage: Conditions such as celiac disease, inflammatory bowel disease (IBD), or bacterial overgrowth that cause damage to the lining of the small intestine, impairing nutrient absorption.
2. Pancreatic insufficiency: A lack of digestive enzymes produced by the pancreas can lead to poor breakdown and absorption of fats, proteins, and carbohydrates. Examples include chronic pancreatitis or cystic fibrosis.
3. Bile acid deficiency: Insufficient bile acids, which are necessary for fat emulsification and absorption, can result in steatorrhea (fatty stools) and malabsorption. This may occur due to liver dysfunction, gallbladder removal, or ileal resection.
4. Motility disorders: Abnormalities in small intestine motility can affect nutrient absorption, as seen in conditions like gastroparesis, intestinal pseudo-obstruction, or scleroderma.
5. Structural abnormalities: Congenital or acquired structural defects of the small intestine, such as short bowel syndrome, may lead to malabsorption.
6. Infections: Certain bacterial, viral, or parasitic infections can cause transient malabsorption by damaging the intestinal mucosa or altering gut flora.

Symptoms of malabsorption syndromes may include diarrhea, steatorrhea, bloating, abdominal cramps, weight loss, and nutrient deficiencies. Diagnosis typically involves a combination of clinical evaluation, laboratory tests, radiologic imaging, and sometimes endoscopic procedures to identify the underlying cause. Treatment is focused on addressing the specific etiology and providing supportive care to manage symptoms and prevent complications.

Medical Definition of Vitamin A:

Vitamin A is a fat-soluble vitamin that is essential for normal vision, immune function, and cell growth. It is also an antioxidant that helps protect the body's cells from damage caused by free radicals. Vitamin A can be found in two main forms: preformed vitamin A, which is found in animal products such as dairy, fish, and meat, particularly liver; and provitamin A carotenoids, which are found in plant-based foods such as fruits, vegetables, and vegetable oils.

The most active form of vitamin A is retinoic acid, which plays a critical role in the development and maintenance of the heart, lungs, kidneys, and other organs. Vitamin A deficiency can lead to night blindness, dry skin, and increased susceptibility to infections. Chronic vitamin A toxicity can cause nausea, dizziness, headaches, coma, and even death.

Muscular diseases, also known as myopathies, refer to a group of conditions that affect the functionality and health of muscle tissue. These diseases can be inherited or acquired and may result from inflammation, infection, injury, or degenerative processes. They can cause symptoms such as weakness, stiffness, cramping, spasms, wasting, and loss of muscle function.

Examples of muscular diseases include:

1. Duchenne Muscular Dystrophy (DMD): A genetic disorder that results in progressive muscle weakness and degeneration due to a lack of dystrophin protein.
2. Myasthenia Gravis: An autoimmune disease that causes muscle weakness and fatigue, typically affecting the eyes and face, throat, and limbs.
3. Inclusion Body Myositis (IBM): A progressive muscle disorder characterized by muscle inflammation and wasting, typically affecting older adults.
4. Polymyositis: An inflammatory myopathy that causes muscle weakness and inflammation throughout the body.
5. Metabolic Myopathies: A group of inherited disorders that affect muscle metabolism, leading to exercise intolerance, muscle weakness, and other symptoms.
6. Muscular Dystonias: Involuntary muscle contractions and spasms that can cause abnormal postures or movements.

It is important to note that muscular diseases can have a significant impact on an individual's quality of life, mobility, and overall health. Proper diagnosis and treatment are crucial for managing symptoms and improving outcomes.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, which are unstable molecules that the body produces as a reaction to environmental and other pressures. Antioxidants are able to neutralize free radicals by donating an electron to them, thus stabilizing them and preventing them from causing further damage to the cells.

Antioxidants can be found in a variety of foods, including fruits, vegetables, nuts, and grains. Some common antioxidants include vitamins C and E, beta-carotene, and selenium. Antioxidants are also available as dietary supplements.

In addition to their role in protecting cells from damage, antioxidants have been studied for their potential to prevent or treat a number of health conditions, including cancer, heart disease, and age-related macular degeneration. However, more research is needed to fully understand the potential benefits and risks of using antioxidant supplements.

Vitamins are organic substances that are essential in small quantities for the normal growth, development, and maintenance of life in humans. They are required for various biochemical functions in the body such as energy production, blood clotting, immune function, and making DNA.

Unlike macronutrients (carbohydrates, proteins, and fats), vitamins do not provide energy but they play a crucial role in energy metabolism. Humans require 13 essential vitamins, which can be divided into two categories: fat-soluble and water-soluble.

Fat-soluble vitamins (A, D, E, and K) are stored in the body's fat tissues and liver, and can stay in the body for a longer period of time. Water-soluble vitamins (B-complex vitamins and vitamin C) are not stored in the body and need to be replenished regularly through diet or supplementation.

Deficiency of vitamins can lead to various health problems, while excessive intake of certain fat-soluble vitamins can also be harmful due to toxicity. Therefore, it is important to maintain a balanced diet that provides all the essential vitamins in adequate amounts.

Vitamin D is a fat-soluble secosteroid that is crucial for the regulation of calcium and phosphate levels in the body, which are essential for maintaining healthy bones and teeth. It can be synthesized by the human body when skin is exposed to ultraviolet-B (UVB) rays from sunlight, or it can be obtained through dietary sources such as fatty fish, fortified dairy products, and supplements. There are two major forms of vitamin D: vitamin D2 (ergocalciferol), which is found in some plants and fungi, and vitamin D3 (cholecalciferol), which is produced in the skin or obtained from animal-derived foods. Both forms need to undergo two hydroxylations in the body to become biologically active as calcitriol (1,25-dihydroxyvitamin D3), the hormonally active form of vitamin D. This activated form exerts its effects by binding to the vitamin D receptor (VDR) found in various tissues, including the small intestine, bone, kidney, and immune cells, thereby influencing numerous physiological processes such as calcium homeostasis, bone metabolism, cell growth, and immune function.

The liver is a large, solid organ located in the upper right portion of the abdomen, beneath the diaphragm and above the stomach. It plays a vital role in several bodily functions, including:

1. Metabolism: The liver helps to metabolize carbohydrates, fats, and proteins from the food we eat into energy and nutrients that our bodies can use.
2. Detoxification: The liver detoxifies harmful substances in the body by breaking them down into less toxic forms or excreting them through bile.
3. Synthesis: The liver synthesizes important proteins, such as albumin and clotting factors, that are necessary for proper bodily function.
4. Storage: The liver stores glucose, vitamins, and minerals that can be released when the body needs them.
5. Bile production: The liver produces bile, a digestive juice that helps to break down fats in the small intestine.
6. Immune function: The liver plays a role in the immune system by filtering out bacteria and other harmful substances from the blood.

Overall, the liver is an essential organ that plays a critical role in maintaining overall health and well-being.

Succinates, in a medical context, most commonly refer to the salts or esters of succinic acid. Succinic acid is a dicarboxylic acid that is involved in the Krebs cycle, which is a key metabolic pathway in cells that generates energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins.

Succinates can also be used as a buffer in medical solutions and as a pharmaceutical intermediate in the synthesis of various drugs. In some cases, succinate may be used as a nutritional supplement or as a component of parenteral nutrition formulations to provide energy and help maintain acid-base balance in patients who are unable to eat normally.

It's worth noting that there is also a condition called "succinic semialdehyde dehydrogenase deficiency" which is a genetic disorder that affects the metabolism of the amino acid gamma-aminobutyric acid (GABA). This condition can lead to an accumulation of succinic semialdehyde and other metabolic byproducts, which can cause neurological symptoms such as developmental delay, hypotonia, and seizures.

Vitamin A deficiency (VAD) is a condition that occurs when there is a lack of vitamin A in the diet. This essential fat-soluble vitamin plays crucial roles in vision, growth, cell division, reproduction, and immune system regulation.

In its severe form, VAD leads to xerophthalmia, which includes night blindness (nyctalopia) and keratomalacia - a sight-threatening condition characterized by dryness of the conjunctiva and cornea, with eventual ulceration and perforation. Other symptoms of VAD may include Bitot's spots (foamy, triangular, white spots on the conjunctiva), follicular hyperkeratosis (goose bump-like bumps on the skin), and increased susceptibility to infections due to impaired immune function.

Vitamin A deficiency is most prevalent in developing countries where diets are often low in animal source foods and high in plant-based foods with low bioavailability of vitamin A. It primarily affects children aged 6 months to 5 years, pregnant women, and lactating mothers. Prevention strategies include dietary diversification, food fortification, and supplementation programs.

Lipid peroxidation is a process in which free radicals, such as reactive oxygen species (ROS), steal electrons from lipids containing carbon-carbon double bonds, particularly polyunsaturated fatty acids (PUFAs). This results in the formation of lipid hydroperoxides, which can decompose to form a variety of compounds including reactive carbonyl compounds, aldehydes, and ketones.

Malondialdehyde (MDA) is one such compound that is commonly used as a marker for lipid peroxidation. Lipid peroxidation can cause damage to cell membranes, leading to changes in their fluidity and permeability, and can also result in the modification of proteins and DNA, contributing to cellular dysfunction and ultimately cell death. It is associated with various pathological conditions such as atherosclerosis, neurodegenerative diseases, and cancer.

Hemolysis is the destruction or breakdown of red blood cells, resulting in the release of hemoglobin into the surrounding fluid (plasma). This process can occur due to various reasons such as chemical agents, infections, autoimmune disorders, mechanical trauma, or genetic abnormalities. Hemolysis may lead to anemia and jaundice, among other complications. It is essential to monitor hemolysis levels in patients undergoing medical treatments that might cause this condition.

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in the synthesis of DNA, formation of red blood cells, and maintenance of the nervous system. It is involved in the metabolism of every cell in the body, particularly affecting DNA regulation and neurological function.

Vitamin B12 is unique among vitamins because it contains a metal ion, cobalt, from which its name is derived. This vitamin can be synthesized only by certain types of bacteria and is not produced by plants or animals. The major sources of vitamin B12 in the human diet include animal-derived foods such as meat, fish, poultry, eggs, and dairy products, as well as fortified plant-based milk alternatives and breakfast cereals.

Deficiency in vitamin B12 can lead to various health issues, including megaloblastic anemia, fatigue, neurological symptoms such as numbness and tingling in the extremities, memory loss, and depression. Since vitamin B12 is not readily available from plant-based sources, vegetarians and vegans are at a higher risk of deficiency and may require supplementation or fortified foods to meet their daily requirements.

Glutathione peroxidase (GPx) is a family of enzymes with peroxidase activity whose main function is to protect the organism from oxidative damage. They catalyze the reduction of hydrogen peroxide, lipid peroxides, and organic hydroperoxides to water or corresponding alcohols, using glutathione (GSH) as a reducing agent, which is converted to its oxidized form (GSSG). There are several isoforms of GPx found in different tissues, including GPx1 (also known as cellular GPx), GPx2 (gastrointestinal GPx), GPx3 (plasma GPx), GPx4 (also known as phospholipid hydroperoxide GPx), and GPx5-GPx8. These enzymes play crucial roles in various biological processes, such as antioxidant defense, cell signaling, and apoptosis regulation.

Vitamin K deficiency is a condition that occurs when the body lacks adequate amounts of Vitamin K, a fat-soluble vitamin essential for blood clotting and bone metabolism. This can lead to an increased risk of excessive bleeding (hemorrhage) and calcification of tissues.

Vitamin K is required for the activation of several proteins involved in blood clotting, known as coagulation factors II, VII, IX, and X. A deficiency in Vitamin K can result in these factors remaining in their inactive forms, leading to impaired blood clotting and an increased risk of bleeding.

Vitamin K deficiency can occur due to several reasons, including malnutrition, malabsorption disorders (such as cystic fibrosis or celiac disease), liver diseases, use of certain medications (such as antibiotics or anticoagulants), and prolonged use of warfarin therapy.

In newborns, Vitamin K deficiency can lead to a serious bleeding disorder known as hemorrhagic disease of the newborn. This is because newborns have low levels of Vitamin K at birth, and their gut bacteria, which are responsible for producing Vitamin K, are not yet fully developed. Therefore, it is recommended that newborns receive a dose of Vitamin K within the first few days of life to prevent this condition.

Symptoms of Vitamin K deficiency can include easy bruising, nosebleeds, bleeding gums, blood in urine or stools, and excessive menstrual bleeding. In severe cases, it can lead to life-threatening hemorrhage. Treatment typically involves administering Vitamin K supplements or injections to replenish the body's levels of this essential nutrient.

Vitamin K Deficiency Bleeding (VKDB) is a condition characterized by an insufficient amount of vitamin K in the body, leading to bleeding complications. It can be further classified into three types:

1. Early onset VKDB: This occurs in the first 24 hours of life and is often seen in infants whose mothers have taken medications that interfere with vitamin K metabolism or who are born prematurely.
2. Classic onset VKDB: This occurs between 2-7 days after birth and is most commonly seen in breastfed infants who have not received vitamin K supplementation at birth.
3. Late onset VKDB: This occurs after the first week of life and can occur up to six months of age. It is often associated with underlying medical conditions that affect vitamin K absorption or metabolism, such as liver disease, cystic fibrosis, or celiac disease.

Symptoms of VKDB may include bleeding from the umbilical cord, gastrointestinal tract, nose, or brain. Treatment typically involves administering vitamin K to stop the bleeding and prevent further complications. Prevention strategies include providing vitamin K supplementation to all newborns at birth.

Vitamin K is a fat-soluble vitamin that plays a crucial role in blood clotting and bone metabolism. It is essential for the production of several proteins involved in blood clotting, including factor II (prothrombin), factor VII, factor IX, and factor X. Additionally, Vitamin K is necessary for the synthesis of osteocalcin, a protein that contributes to bone health by regulating the deposition of calcium in bones.

There are two main forms of Vitamin K: Vitamin K1 (phylloquinone), which is found primarily in green leafy vegetables and some vegetable oils, and Vitamin K2 (menaquinones), which is produced by bacteria in the intestines and is also found in some fermented foods.

Vitamin K deficiency can lead to bleeding disorders such as hemorrhage and excessive bruising. While Vitamin K deficiency is rare in adults, it can occur in newborns who have not yet developed sufficient levels of the vitamin. Therefore, newborns are often given a Vitamin K injection shortly after birth to prevent bleeding problems.

Vitamin K1, also known as phylloquinone, is a type of fat-soluble vitamin K. It is the primary form of Vitamin K found in plants, particularly in green leafy vegetables such as kale, spinach, and collard greens. Vitamin K1 plays a crucial role in blood clotting and helps to prevent excessive bleeding by assisting in the production of several proteins involved in this process. It is also essential for maintaining healthy bones by aiding in the regulation of calcium deposition in bone tissue. A deficiency in Vitamin K1 can lead to bleeding disorders and, in some cases, osteoporosis.

Cottonseed oil is a type of vegetable oil that is extracted from the seeds of cotton plants. It is commonly used in cooking and food manufacturing due to its mild flavor, high smoke point, and long shelf life. Cottonseed oil is also used in the production of soaps, cosmetics, and industrial lubricants.

In a medical context, cottonseed oil is not typically used as a treatment or therapy. However, it does contain various nutrients and compounds that may have potential health benefits. For example, cottonseed oil is a good source of vitamin E, which has antioxidant properties that can help protect cells from damage. It also contains essential fatty acids like linoleic acid, which are important for maintaining heart health and reducing inflammation.

It's worth noting that cottonseed oil does contain small amounts of gossypol, a naturally occurring toxin found in cotton plants. While the levels of gossypol in cottonseed oil are generally considered safe for human consumption, high doses or long-term exposure can be harmful. Therefore, it's important to consume cottonseed oil in moderation and as part of a balanced diet.

Vitamin K2, also known as menaquinone, is a fat-soluble vitamin that plays a crucial role in the blood clotting process and bone metabolism. It is one of the two main forms of Vitamin K (the other being Vitamin K1 or phylloquinone), and it is found in animal-based foods and fermented foods.

Vitamin K2 is a collective name for a group of vitamin K compounds characterized by the presence of a long-chain fatty acid attached to the molecule. The most common forms of Vitamin K2 are MK-4 and MK-7, which differ in the length of their side chains.

Vitamin K2 is absorbed more efficiently than Vitamin K1 and has a longer half-life, which means it stays in the body for a longer period. It is stored in various tissues, including bones, where it plays an essential role in maintaining bone health by assisting in the regulation of calcium deposition and helping to prevent the calcification of blood vessels and other soft tissues.

Deficiency in Vitamin K2 is rare but can lead to bleeding disorders and weakened bones. Food sources of Vitamin K2 include animal-based foods such as liver, egg yolks, and fermented dairy products like cheese and natto (a Japanese food made from fermented soybeans). Some studies suggest that supplementing with Vitamin K2 may have benefits for bone health, heart health, and cognitive function. However, more research is needed to confirm these potential benefits.

Naval medicine, also known as marine medicine or maritime medicine, is a branch of medicine that deals with the prevention and treatment of diseases and injuries that occur in naval or maritime environments. This can include conditions related to sea travel, such as motion sickness, decompression sickness, and infectious diseases spread through contaminated water or food. It also covers occupational health concerns for naval personnel, including hearing loss from exposure to loud noises, respiratory problems from inhaling fumes, and musculoskeletal injuries from heavy lifting. Additionally, naval medicine may address the unique mental health challenges faced by naval personnel, such as those related to isolation, stress, and combat.

An expedition, in a medical context, is not a term that has a specific or technical meaning. The term "expedition" generally refers to a journey or voyage undertaken with a particular purpose, often to explore or discover new information or territories. In a medical or healthcare setting, an expedition might refer to a research project or mission to provide medical care and assistance in remote or underserved areas. For example, a group of doctors, nurses, and support staff might embark on a medical expedition to provide care and treatment to people living in a rural community with limited access to healthcare services. However, the use of the term "expedition" in this context is not common, and it is more likely that such a journey would be referred to as a "medical mission" or "humanitarian aid trip."

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

I'm sorry for any confusion, but "morale" is not a term that has a specific medical definition. Morale generally refers to the overall psychological and emotional well-being or spirit of an individual or group, often in relation to their work, military service, or other collective endeavors. It encompasses factors such as confidence, motivation, and job satisfaction.

However, in a broader sense, morale can be related to mental health and well-being, which are certainly important aspects of medical care and treatment. Factors that contribute to positive morale, like social connections, meaningful activities, and a sense of purpose, can also support overall mental health and resilience.

Medical manuscripts are written documents that describe original research, analysis, or experiences in the field of medicine. These can take various forms such as:

1. Research papers: These report on original studies and include an abstract, introduction, methods, results, discussion, and conclusion sections. They may also include tables, figures, and appendices.

2. Review articles: These provide a comprehensive overview of a specific topic in medicine, summarizing recent developments and findings from multiple sources.

3. Case reports: These describe unusual or interesting medical cases, often serving as educational tools for other healthcare professionals.

4. Clinical trials: These are detailed descriptions of clinical research studies involving human subjects, following a standardized format that includes information on the study's design, methods, results, and conclusions.

5. Systematic reviews and meta-analyses: These involve a rigorous evaluation of all available evidence on a specific research question, using systematic methods to identify, select, and critically appraise relevant studies.

6. Letters to the editor: These are brief communications that may comment on previously published articles or raise new issues for discussion in the medical community.

Medical manuscripts must adhere to strict ethical guidelines and should be written in a clear, concise, and well-organized manner, following the standards set by reputable medical journals. They undergo rigorous peer review before publication to ensure their quality, accuracy, and relevance to the field of medicine.

The term "Arabic Medicine" refers to the medical knowledge and practices that were developed by scholars in the Islamic world, which stretched from Spain to Persia during the Middle Ages (approximately 8th to 15th centuries). This period saw a flourishing of intellectual activity in many fields, including medicine.

Arabic medicine was heavily influenced by ancient Greek and Roman medical texts, particularly those of Galen and Hippocrates. These texts were translated into Arabic and studied by Islamic scholars, who built upon this foundation to make significant contributions of their own.

One of the most famous Arabic physicians was Avicenna (Ibn Sina), who wrote the Canon of Medicine, a comprehensive medical text that was widely used in Europe and the Middle East for centuries. Other notable Arabic physicians include Al-Razi (Rhazes) and Ibn al-Nafis, who made important discoveries in anatomy and physiology.

Arabic medicine encompassed a wide range of topics, including anatomy, pharmacology, surgery, and public health. It emphasized the importance of observation, experimentation, and critical thinking in medical practice, and placed a strong emphasis on the use of rational methods to diagnose and treat illness.

Overall, Arabic medicine played a crucial role in preserving and advancing medical knowledge during the Middle Ages, and its influence can still be seen in modern medical practices today.

I believe there might be a bit of confusion in your question. A "history" in medical terms usually refers to the detailed account of a patient's symptoms, illnesses, and treatments received, which is used by healthcare professionals to understand their health status and provide appropriate care. It is not typically associated with a specific century like the 17th century.

If you are asking for information about the medical practices or significant developments in the field of medicine during the 17th century, I would be happy to provide some insight into that. The 17th century was a time of great advancement in medical knowledge and practice, with several key figures and events shaping the course of medical history.

Some notable developments in medicine during the 17th century include:

1. William Harvey's discovery of the circulation of blood (1628): English physician William Harvey published his groundbreaking work "De Motu Cordis" (On the Motion of the Heart and Blood), which described the circulatory system and the role of the heart in pumping blood throughout the body. This discovery fundamentally changed our understanding of human anatomy and physiology.
2. The development of the microscope (1600s): The invention of the microscope allowed scientists to observe structures that were previously invisible to the naked eye, such as cells, bacteria, and other microorganisms. This technology opened up new avenues of research in anatomy, physiology, and pathology, paving the way for modern medical science.
3. The establishment of the Royal Society (1660): The Royal Society, a prominent scientific organization in the UK, was founded during this century to promote scientific inquiry and share knowledge among its members. Many notable scientists and physicians, including Robert Hooke and Christopher Wren, were part of the society and contributed significantly to the advancement of medical science.
4. The Smallpox Vaccination (1796): Although this occurred near the end of the 18th century, the groundwork for Edward Jenner's smallpox vaccine was laid during the 17th century. Smallpox was a significant public health issue during this time, and Jenner's development of an effective vaccine marked a major milestone in the history of medicine and public health.
5. The work of Sylvius de le Boe (1614-1672): A Dutch physician and scientist, Sylvius de le Boe made significant contributions to our understanding of human anatomy and physiology. He was the first to describe the circulation of blood in the lungs and identified the role of the liver in metabolism.

These are just a few examples of the many advancements that took place during the 17th century, shaping the course of medical history and laying the foundation for modern medicine.

... vitamin A, vitamin B6, vitamin B12, vitamin D and vitamin E. As of 21 December 2018, 81 countries required food fortification ... Vitamin deficiency is the condition of a long-term lack of a vitamin. When caused by not enough vitamin intake it is classified ... "Vitamin B12 Deficiency Anemia , Michigan Medicine". www.uofmhealth.org. Retrieved 8 October 2021. "How a Vitamin B Deficiency ... Other B Vitamins (1998). "Vitamin B6". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin ...
Severe vitamin B12 deficiency can damage nerve cells. If this happens, vitamin B12 deficiency may result in sense loss, loss of ... If vitamin B12 deficiency exists with folate deficiency, vitamin B12 should be replaced first to prevent subacute combined ... "Vitamin B12 Deficiency Anemia , Michigan Medicine". www.uofmhealth.org. Retrieved 2021-10-08. "How a Vitamin B Deficiency ... "Vitamin B12 Deficiency - Disorders of Nutrition". MSD Manual Consumer Version. Retrieved 2021-10-15. "Vitamin B12 Deficiency: ...
... such as for fortified rice or vitamin A-rich sweet potato, may be more effective in eradicating vitamin A deficiency. "Vitamin ... Global prevalence of vitamin A deficiency in populations at risk 1995-2005, WHO global database on vitamin A deficiency. Black ... Vitamin A deficiency (VAD) or hypovitaminosis A is a lack of vitamin A in blood and tissues. It is common in poorer countries, ... Other causes of vitamin A deficiency are inadequate intake, fat malabsorption, or liver disorders. Deficiency impairs immunity ...
There is a rare genetic condition termed isolated vitamin E deficiency or 'ataxia with isolated with vitamin E deficiency', ... Treatment is oral vitamin E supplementation. Familial isolated vitamin E deficiency Abetalipoproteinemia Tocopherol Institute ... Vitamin E deficiency in humans is a very rare condition, occurring as a consequence of abnormalities in dietary fat absorption ... Signs of vitamin E deficiency include the following: Neuromuscular problems - such as spinocerebellar ataxia and myopathies. ...
... results from insufficient dietary vitamin K1 or vitamin K2 or both. Symptoms include bruising, petechiae, ... The prevalence of vitamin K deficiency varies by geographic region. For infants in the United States, vitamin K1 deficiency ... Vitamin K is changed to its active form in the liver by the enzyme Vitamin K epoxide reductase. Activated vitamin K is then ... Vitamin K1-deficiency may occur by disturbed intestinal uptake (such as would occur in a bile duct obstruction), by therapeutic ...
Evidence suggests that vitamin D deficiency may be associated with impaired immune function. Those with vitamin D deficiency ... Vitamin D deficiency can also be caused by inadequate nutritional intake of vitamin D; disorders that limit vitamin D ... Vitamin D deficiency or hypovitaminosis D is a vitamin D level that is below normal. It most commonly occurs in people when ... Vitamin D deficiency is associated with the development of schizophrenia. Vitamin D can be synthesized in the skin under the ...
This combination can lead to vitamin K deficiency and later onset bleeding. Vitamin K deficiency leads to the risk of blood ... Newborns are relatively vitamin K deficient for a variety of reasons: They have low vitamin K stores at birth as vitamin K ... Vitamin K deficiency bleeding (VKDB) of the newborn, previously known as haemorrhagic disease of the newborn, is a rare form of ... Classical VKDB is more common and caused by the relative deficiency at birth with inadequate vitamin K intake. This is often ...
"Vitamin D in Australia" (PDF). "Vitamin D deficiency and multicultural Australia". The Medical Journal of Australia. 2001. ... Vitamin D deficiency Vitamin D Sun exposure "Australian Health Survey: Biomedical Results for Nutrients, 2011-12" (PDF). ... they were considered safe from a deficiency. Nowadays through technological advancements Vitamin D deficiencies are now ... Moderate deficiency: 13 - 29nmol/L •Severe deficiency: < 13 nmol/L In 1997, the prevalence of deficiency, defined as < 50 years ...
Vitamin E deficiency TTPA "Ataxia with vitamin E deficiency". www.orpha.net. Retrieved 2017-01-19. Doerflinger N, Linder C, ... Familial isolated vitamin E deficiency or Ataxia with vitamin E deficiency (AVED) is a rare autosomal recessive ... "Ataxia with Vitamin E Deficiency". NCBI Bookshelf. PMID 20301419. Retrieved 2022-11-13. Ataxia with vitamin E deficiency at ... Familial isolated vitamin E deficiency is caused by mutations in the gene for a-tocopherol transfer protein. Symptoms manifest ...
"Vitamin deficiency". The Guardian, 6 January 2005. Retrieved 6 January 2007. Goldacre, Ben. "Working papers". The Guardian, 20 ... The real crime here is that no full-scale human trials have been funded on vitamin C to follow up Jariwalla's important finding ... Goldacre writes that Holford based this conclusion on a non-clinical study where "you tip lots of vitamin C onto HIV-infected ... He argues that "Holford was guilty of at least incompetence in claiming that this study demonstrated vitamin C to be a better ...
Holick, M. F (2007). "Vitamin D deficiency". New England Journal of Medicine. 357 (3): 266-81. doi:10.1056/NEJMra070553. PMID ... 7-Dehydrocholesterol from lanolin is used as a raw material for producing vitamin D3 by irradiation with ultraviolet light. ... also used in vitamins" (PDF). American Journal of Engineering Research (AJER). 3 (7): 33-43. Archived (PDF) from the original ...
Pancreatic cancer cell in high magnification Scurvy is a nutritional deficiency of water-soluble vitamin C or ascorbic acid. It ... Maxfield L, Crane JS (October 2022). "Vitamin C Deficiency.". StatPearls [Internet]. Treasure Island (FL): StatPearls ...
Specific cases include: Vitamin K deficiency: In the liver, vitamin K plays an important role in the synthesis of coagulation ... The liver synthesizes inactive precursor proteins in the absence of vitamin K (liver disease). Vitamin K deficiency leads to ... Vitamin K-dependent coagulation factors have a very short half-life, sometimes leading to a deficiency when a depletion of ... A vitamin K-dependent clotting factor is seldom seen as a contributor to inherited prothrombin deficiencies, but lack of ...
"Vitamin Deficiency Anemia". Mayo Clinic. Pirklbauer M (July 2020). "Hemodialysis treatment in patients with severe electrolyte ... Folate deficiency can occur in some patients having hemodialysis. Although a dyalisate fluid, which is a solution containing ...
Many South Africans also have a Thiamine (Vitamin B1) deficiency. A serious deficiency in this vital nutrient can cause ... due to the detrimental effects of Vitamin A on the immune system. Vitamin C deficiency also has detrimental effects on the ... An additional malnutrition problem is a deficiency in vitamin A. It is especially prominent in the Northern Province, the ... West Jr., K. (1 September 2002). "Extent of Vitamin A Deficiency Among Preschool children and Women of Reproductive Age". The ...
Mayo Clinic staff (March 4, 2011). "Vitamin deficiency anemia". Mayo Foundation for Medical Education and Research. Mayo Clinic ... "Folate-deficiency anemia". National Center for Biotechnology Information. U.S. National Library of Medicine. 31 January 2010. ... Hall, C. A. (November 1975). "Transcobalamins I and II as natural transport proteins of vitamin B12". J. Clin. Invest. 56 (5): ... Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (1981). "Deficiency of protein C in congenital thrombotic disease". J. ...
It demonstrates the ability for humans to develop and innovate themselves out of problems, such as the deficiency of vitamin A ... "Vitamin A Deficiency". www.goldenrice.org. Retrieved 2015-10-31. "NPIC - National Pesticide Information Centre" (PDF). "The DDT ... GM crops can create many advantages, such as higher food fields, added vitamins and increased farm profits. Depending on the ... a precursor of vitamin A). This enables healthier and fulfilling lifestyles for these individuals and consequently helps to ...
Sommer, Alfred; West, Keith P. (1996). Vitamin A Deficiency. Oxford University Press. p. 352. Prabhune, Meenakshi (April 6, ... she worked with Alfred Sommer to analyze data to uncover a link between vitamin A deficiency (VAD) and an increased risk for ... "The Story of Vitamin A". Johns Hopkins Bloomberg School of Public Health. 2003. Retrieved May 25, 2021. Howard, Brandon (May ... Her research has also sought to find low cost interventions to reduce micronutrient deficiencies, infectious diseases, and poor ...
... vitamin D deficiency; higher levels of poverty than the figures suggest; and adverse childhood experiences. Housing in Glasgow ... vitamin D deficiency, cold winters, higher levels of poverty than the figures suggest, adverse childhood experiences and ...
Holick, Michael F. (2007). "Vitamin D Deficiency". New England Journal of Medicine. 357 (3): 266-281. doi:10.1056/NEJMra070553 ... that the UVB doses produced by tanning beds exceed what is needed for adequate vitamin D production, and that adequate vitamin ... Vitamin D is produced when the skin is exposed to UVB, whether from sunlight or an artificial source. It is needed for ... Obtaining vitamin D from indoor tanning has to be weighed against the risk of developing skin cancer. The indoor-tanning ...
... and B vitamin deficiency. The protein in cottonseed meal is also low in lysine. Glandless cottonseed was developed in the early ...
B; Smith M (2015). "Vitamins and supplements lifestyle guide. Calcium;". Sahota, O. (2014). "Understanding vitamin D deficiency ... 1-2 serves of fruit (150g) should also be consumed daily as it is essential in preventing early onset vitamin deficiencies. 1- ... Vitamin D, also coined as the sunshine vitamin, is necessary within a child's diet as it allows body tissues and in particular ... Perlstein, D. (2015). "Rickets (Calcium, Phosphate, or Vitamin D Deficiency) Pg 1". Inglis, V.; Ball, K.; Crawford, D. (2005 ...
"Vitamin C Deficiency (Scurvy)". Vitamin Deficiency Info (blog). Retrieved 2 January 2023. Saloheimo P (2005). "[Captain Cook ... Many health benefits have been claimed for sauerkraut: It is a high source of vitamins C and K; the fermentation process ...
Similarly, vitamin A deficiency can cause an increase in the severity of diarrheal episodes. However, there is some discrepancy ... Rice AL, West KP, Black RE (2004). "Vitamin A deficiency" (PDF). In Ezzati M, Lopez AD, Rodgers A, Murray CJ (eds.). ... West KP (September 2002). "Extent of vitamin A deficiency among preschool children and women of reproductive age". The Journal ... "Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency". The American ...
Intrinsic factor is required for the absorption of vitamin B12 in the diet. A long-term deficiency in vitamin B12 can lead to ... "Vitamin B12 deficiency" (PDF). BMJ. 349: g5226. doi:10.1136/bmj.g5226. PMID 25189324. S2CID 28782021. Archived from the ... Atrophic gastritis, particularly in the elderly, will cause an inability to absorb B12 and can lead to deficiencies such as ... In pernicious anemia, autoantibodies directed against parietal cells or intrinsic factor cause a reduction in vitamin B12 ...
Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM (October 2006). "Risk factors of vitamin B(12) deficiency in patients receiving ... May 2010). "Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised ... Higher doses and prolonged use are associated with increased incidence of vitamin B12 deficiency, and some researchers ... Andrès E, Noel E, Goichot B (October 2002). "Metformin-associated vitamin B12 deficiency". Archives of Internal Medicine. 162 ( ...
Vitamin B1 deficiency (thiamine deficiency) was reported to cause seizures, especially in alcoholics. Vitamin B6 depletion ( ... pyridoxine deficiency) was reported to be associated with pyridoxine-dependent seizures. Vitamin B12 deficiency was reported to ... Yavuz, Halûk (2008). "Vitamin B12 deficiency and seizures". Developmental Medicine and Child Neurology. 50 (9): 720. doi: ... Kumar, S (2004). "Recurrent seizures: an unusual manifestation of vitamin B12 deficiency". Neurology India. 52 (1): 122-3. PMID ...
Hastings, V. E. (1938). "Cancer And Vitamin A Deficiency". The British Medical Journal. 1 (4042): 1390. doi:10.1136/bmj.1.4042. ...
... tuberculosis and vitamin D deficiency. His study was the first of its kind which documented the widespread deficiency of ... Sasidharan, P.K; Vijayakumari V; Rajeev E (April 2002). "Tuberculosis and Vitamin D deficiency". J Assoc Physicians India. 50 ( ... the most prominent among them being the landmark study on Vitamin D deficiency in Tuberculosis which established the link ... Besides these, there are original studies on B12 deficiency, reversal of diabetes, reversal of nonalcoholic fatty liver disease ...
Vitamin D deficiency can occur. Vitamin D binding protein is lost. Hypocalcaemia: lack of 25-hydroxycholecalciferol (the way ... In addition to these key imbalances, vitamin D and calcium are also taken orally in case the alteration of vitamin D causes ... Hypothyroidism: deficiency of the thyroglobulin transport protein thyroxin (a glycoprotein that is rich in iodine and is found ... that vitamin D is stored in the body). As vitamin D regulates the amount of calcium present in the blood, a decrease in its ...
... deficiency) can affect your bones and overall health. Learn who is at risk, how much vitamin D you need, and how to get enough. ... What is vitamin D deficiency?. Vitamin D deficiency means that your body is not getting enough vitamin D to stay healthy. ... What causes vitamin D deficiency?. You can become deficient in vitamin D for different reasons:. *You dont get enough vitamin ... What problems does vitamin D deficiency cause?. Vitamin D deficiency can lead to a loss of bone density, which can contribute ...
Dr David Johnson on why we should consider vitamin D supplementation beyond its benefits for bone health. ... to determine colorectal cancer risk at various ranges of vitamin D. They used the traditional measure for vitamin D deficiency ... This new study supports the idea that vitamin D deficiency makes a difference. Researchers pooled data from 17 study cohorts ( ... Cite this: Vitamin D Deficiency Elevates Colorectal Cancer Risk - Medscape - Nov 15, 2018. ...
... deficiency can occur in any age group but is encountered most often in infancy. VK, an essential, lipid-soluble vitamin that ... encoded search term (Vitamin K Deficiency) and Vitamin K Deficiency What to Read Next on Medscape ... Morbidity correlates with the severity of vitamin K deficiency. The risk of developing vitamin K deficiency bleeding is 81 ... Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. J Perinatol. 2016 May. 36 Suppl 1: ...
... vitamin A, vitamin B6, vitamin B12, vitamin D and vitamin E. As of 21 December 2018, 81 countries required food fortification ... Vitamin deficiency is the condition of a long-term lack of a vitamin. When caused by not enough vitamin intake it is classified ... "Vitamin B12 Deficiency Anemia , Michigan Medicine". www.uofmhealth.org. Retrieved 8 October 2021. "How a Vitamin B Deficiency ... Other B Vitamins (1998). "Vitamin B6". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin ...
... using serum cobalamin assay to diagnosis vitamin B12 deficiency has its limitations. "Functional" vitamin B12 deficiency is a ... Autonomic dysfunction in vitamin B12 deficiency: a heart rate variability study. J Auton Nerv Syst 1998;71:25-7.. 5- Aytemir K ... The clinical review of vitamin B12 deficiency by Hunt et al was concise and informative. However, it did not mention autonomic ... The exact mechanism of excessive sweating in vitamin-B12 deficiency is a matter of speculation and will require further studies ...
Late Vitamin K Deficiency Bleeding in Infants Whose Parents Declined Vitamin K Prophylaxis - Tennessee, 2013. Vitamin K ... Sutor AH, Kries R, Cornelissen EAM, McNinch AW, Andrew M. Vitamin K deficiency bleeding (VKDB) in infancy. Thromb Haemost 1999; ... In adults, vitamin K is absorbed from food and from vitamin K synthesized by gut bacteria. However, placental transfer in ... Zipursky A. Prevention of vitamin K deficiency bleeding in newborns. Br J Haematol 1999;104:430-7. ...
Learn about vitamin K deficiency in adults and infants. ... The main symptom of a vitamin K deficiency is bleeding caused ... Vitamin K deficiency is much more likely to occur in infants. When it does, it is known as vitamin K deficiency bleeding or ... Vitamin K deficiency in adults is very rare, as most people get sufficient vitamin K from their diet. If a deficiency does ... What is vitamin B12 deficiency?. Medically reviewed by Emelia Arquilla, DO. Vitamin B12 is crucial for the formation of red ...
What causes vitamin D deficiency? Learn the signs and symptoms of vitamin D deficiency including fatigue, depression, and other ... Could you be at risk for vitamin D deficiency? ... The Vitamin D Council. How do I get the vitamin D my body needs ... What are signs and symptoms of vitamin D deficiency?. The symptoms of vitamin D deficiency can be nonspecific such as fatigue, ... Other people who have vitamin D deficiency may not notice any symptoms. People with a severe vitamin D deficiency can have ...
Conventional wisdom says that oral B12 is too poorly absorbed to be able to correct a deficiency. Is that really true? ... Cite this: Treating Vitamin B12 Deficiency: What Formulation Is Best? - Medscape - Mar 09, 2020. ... Metformin Use Linked to Worse Cognition, B-Vitamin Deficiency * 2001. High Rates of B Vitamin Deficiency in Teens With Mental ...
... had substantial improvement in their symptoms of depression after they received treatment for their vitamin D deficiency, a new ... Because the women had risk factors for vitamin D deficiency, such as low vitamin D intake and poor sun exposure, they each ... Levels below 21 ng/mL are considered vitamin D deficiency, and normal vitamin D levels are above 30 ng/mL, according to The ... Treating vitamin D deficiency may improve depression. Date:. June 25, 2012. Source:. Endocrine Society. Summary:. Women with ...
To assess the association between vitamin D deficiency and tuberculosis disease progression, we studied vitamin D levels in a ... Gibney KB, MacGregor L, Leder K, Torresi J, Marshall C, Ebeling PR, Vitamin D deficiency is associated with tuberculosis and ... for a relative 1-log decrement in vitamin D levels, which suggests that vitamin D deficiency might be a strong risk factor for ... Vitamin D deficiency in an ample sunlight country. J Coll Physicians Surg Pak. 2009;19:267-8.PubMedGoogle Scholar ...
... higher for subjects with vitamin D deficiency at the start of the study than for subjects with normal vitamin D levels and 77% ... Vitamin D deficiency increases risk of losing muscle strength by 78%. Fundação de Amparo à Pesquisa do Estado de São Paulo ... Vitamin D deficiency increases risk of losing muscle strength by 78% Researchers in Brazil and the UK analyzed data for more ... There are many more days of sunlight per year in Brazil, and yet were known to have a high incidence of vitamin D deficiency ...
The proper diagnostic term that has been adopted is currently vitamin K deficiency bleeding because vitamin K deficiency is not ... Late-onset vitamin K deficiency bleeding in the newborn. Late-onset vitamin K deficiency bleeding usually occurs between age 2- ... Early-onset vitamin K deficiency bleeding in the newborn. Early-onset vitamin K deficiency bleeding usually occurs during first ... Classic vitamin K deficiency bleeding in the newborn. Classic vitamin K deficiency bleeding usually occurs after 24 hours after ...
Learn more from WebMD about how to get plenty of vitamin D, and how to treat a vitamin D deficiency. ... Vitamin D is essential for healthy bones, and a lack of it can lead to health problems, including cardiovascular disease. ... Treatment for Vitamin D Deficiency. Treatment for vitamin D deficiency involves getting more vitamin D -- through diet and ... Tests for Vitamin D Deficiency. The most accurate way to measure how much vitamin D is in your body is the 25-hydroxy vitamin D ...
Efforts to tackle obesity should thus also help to reduce levels of vitamin D deficiency in the population, says the lead ... Obesity can lead to a lack of vitamin D circulating in the body, a new study suggests. ... Link Between Neonatal Vitamin D Deficiency and Schizophrenia Confirmed. Dec. 6, 2018 Newborns with vitamin D deficiency have an ... Vitamin D deficiency is a growing public health concern, and there is evidence that vitamin D metabolism, storage and action ...
This article explains some of the symptoms and causes of vitamin D deficiency, as well as how to treat it. ... Vitamin D deficiency is incredibly common in Western countries. ... While vitamin D deficiency may be seen in cases of obesity, ... Vitamin D deficiency occurs when the body doesnt get enough vitamin D from sunlight or diet. Vitamin D deficiency can cause ... 1,25-dihydroxy vitamin D, or calcitriol. The most common test for vitamin D deficiency is the 25-hydroxy vitamin D test. This ...
... vitamin B1) many years ago. It functions as a catalyst in the generation of energy through decarboxylation of branched-chain ... Review Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins.[ ... Review Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins.. ... Vitamin B1 (Thiamine) Deficiency. Kimberly D. Wiley; Mohit Gupta.. Author Information and Affiliations. Authors. Kimberly D. ...
All posts tagged with vitamin C deficiency. * Study finds people with type 2 diabetes and obesity have lower vitamin C levels. ... Natural News) Vitamin C gets a lot of buzz during cold season, but it turns out that the nutrient also has a substantial effect ... Natural News) A recent study out of New Zealand has found an inverse relationship between the levels of vitamin C in a persons ... in: Food, Health, Mental Health, nervous system, Nutrition, Superfoods & healing foods, Vitamin C ...
... were rigorously reviewed and revised by a working group and presented for discussion at the XX International Vitamin A ... Comprehensive recommendations for the assessment and control of vitamin A deficiency (VAD) ... Assessment and control of vitamin A deficiency: the Annecy Accords J Nutr. 2002 Sep;132(9 Suppl):2845S-2850S. doi: 10.1093/jn/ ... Fortification, supplementation, or other means of increasing vitamin A intake are needed to correct widespread deficiency. To ...
... is a B-complex vitamin involved in over 150 enzyme reactions. Here are 9 signs and symptoms of vitamin B6 deficiency. ... Vitamin B deficiencies can cause a wide range of symptoms. Learn the importance of each B vitamin, their deficiency symptoms, ... One reason B6 deficiency may result in skin rashes is that the vitamin helps synthesize collagen, which is needed for healthy ... Vitamin B6 deficiency may lead to a variety of signs and symptoms, including skin rashes, mood changes, and low energy. To ...
Vitamin B12 deficiency can cause various clinical manifestations. Are you familiar with risk factors, key aspects of ... Vitamin B12 deficiency can cause various neurologic diseases and other clinical manifestations. Its incidence widely varies on ... In the United States and the United Kingdom, the prevalence of vitamin B12 deficiency in individuals aged , 60 years is ... Are you familiar with risk factors for the development of vitamin B12 deficiency, as well as related key aspects, clinical ...
... deficiency) can affect your bones and overall health. Learn who is at risk, how much vitamin D you need, and how to get enough. ... What is vitamin D deficiency?. Vitamin D deficiency means that your body is not getting enough vitamin D to stay healthy. ... What causes vitamin D deficiency?. You can become deficient in vitamin D for different reasons:. *You dont get enough vitamin ... What problems does vitamin D deficiency cause?. Vitamin D deficiency can lead to a loss of bone density, which can contribute ...
Its the vitamin that we get from the sun, yet despite its ample availability, one in three Australian adults still suffer from ... "While severe vitamin D deficiency is rarer in Australia than elsewhere in the world, it can still affect those who have health ... Vitamin D deficiency linked to premature death. October 26, 2022. University of South Australia ... "Vitamin D deficiency has been connected with mortality, but as clinical trials have often failed to recruit people with low ...
Here we break down the best foods to eat for every vitamin deficiency and what pairings are best for maximum nutrient ... Best Foods to Eat for Every Vitamin Deficiency. Experts Reveal the Foods That Can Help You Cover All Your Vitamin Bases. ... and simply cover your bases when it comes to common vitamin deficiencies - from vitamin A to Omega-3 and everything in between. ... Still, common vitamin deficiencies can lurk under the surface if youre not pairing your food properly. It might sound a little ...
Vitamin D status of Asian mothers in Cardiff was investigated during early pregnancy and at the time of the birth of their ... Vitamin D deficiency: a concern in pregnant Asian women Br J Nutr. 1995 Jun;73(6):881-7. doi: 10.1079/bjn19950093. ... These findings suggest that subclinical vitamin D deficiency is still a cause for concern in Asian women. More active measures ... Vitamin D status of Asian mothers in Cardiff was investigated during early pregnancy and at the time of the birth of their ...
... is a vitamin K-dependent proenzyme that functions in the blood coagulation cascade. Factor II deficiency is a rare, inherited ... Vitamins, Fat-Soluble. Class Summary. Fat-soluble vitamins may play essential role in the function of clotting factors. ... encoded search term (Factor II Deficiency) and Factor II Deficiency What to Read Next on Medscape ... Factor II Deficiency Medication. Updated: Mar 16, 2021 * Author: Robert A Schwartz, MD, MPH; Chief Editor: Perumal Thiagarajan ...
Learn about Ataxia with Vitamin E Deficiency, including symptoms, causes, and treatments. If you or a loved one is affected by ... Ataxia with Vitamin E Deficiency. Medline Plus. Updated Dec 1, 2015. Ataxia with vitamin E deficiency: MedlinePlus Genetics ... Vitamin E deficiency often occurs secondary to disorders that impair the absorption of vitamin E from fat including liver ... Premature infants may have low vitamin E levels due to small amounts of vitamin E cross the placenta. In rare cases vitamin E ...
The most important treatment for Vitamin A deficiency is changing the turtles diet to include adequate amounts of Vitamin A. ... As this supply of Vitamin A is depleted, the turtle must eat foods with adequate amounts of vitamin A. Good sources of Vitamin ... Vitamin A toxicity) presents similar to Vitamin A deficiency with red, inflamed skin which frequently sloughs. ... The symptoms of Vitamin A deficiency are very similar to the symptoms for other diseases so it is important to rule out other ...
Vitamin B2 Deficiency. George E. Meinig, DDS / March 31, 2005. Published on the Price-Pottenger Nutrition Foundation website, ... This is not a vitamin B2 deficiency but of course both things could exist at the same time. ... This vitamin is lost in the refining of grain, exposure of food to sunlight, and some of it is lost by heating food and when it ... When the corners of the mouth are cracked it is common to see that skin and eyes are also often involved with deficiencies of ...
Seventy-five percent of mothers had vitamin D deficiency, and 26 percent had blood vitamin D levels considered very low. Only ... "Vitamin D deficiency is the major cause of rickets around the world, but rickets may be just the tip of the iceberg," says Dr. ... "Vitamin D deficiency is also common in Arab women during pregnancy and is detrimental to the health of both mother and child," ... Vitamin D deficiency is largely due to how Arab women dress outdoors - preventing exposure of the skin to sunlight - and low ...

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