Detachment of the corpus vitreum (VITREOUS BODY) from its normal attachments, especially the retina, due to shrinkage from degenerative or inflammatory conditions, trauma, myopia, or senility.
Visual sensation derived from sensory stimulation by objects or shadows inside the eye itself, such as floating vitreous fibers, tissues, or blood.
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.
A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.
Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
Diseases affecting the eye.
Hemorrhage into the VITREOUS BODY.
An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.
An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90)
An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The administration of substances into the VITREOUS BODY of the eye with a hypodermic syringe.
A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.
Introduction of substances into the body using a needle and syringe.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
An operation for retinal detachment which reduces the size of the globe by indenting the sclera so that it approximates the retina.
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
Value of all final goods and services produced in a country in one year.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.

Treatment of retinal tears and lattice degenerations in fellow eyes in high risk patients suffering retinal detachment: a prospective study. (1/53)

BACKGROUND/AIMS: Fellow eye prophylaxis for retinal detachment (RD) is still a controversial issue since opinions are not unanimous regarding the kind of lesions to be treated or the method of treatment. This prospective clinical study aimed to follow the course of vitreoretinal conditions in 150 high risk fellow eyes. METHODS: 150 consecutive patients with unilateral rhegmatogenous RD were included in this study. Inclusion criteria were good explorability of fellow eye retinal periphery and one of the following conditions in the fellow eye-aphakia, pseudophakia with capsulotomy, high myopia (>-6D), contralateral eye to a giant retinal tear. Prophylactic treatment (photocoagulation or scleral buckling) was performed in the presence of retinal tears and lattice degenerations. The state of the vitreous body was determined at the beginning of the study and at the end, when RD occurred. RESULTS: Follow up ranged from 36 to 132 months. 95 fellow eyes were subjected to laser treatment; five eyes underwent prophylactic surgical treatment. Initially, in the treated group posterior vitreous detachment (PVD) was present in 100 eyes (100% of cases), but as a complete PVD only in 42 of them (42%). 10 eyes in the treated group developed RD during the follow up period. In five of these cases the partial PVD had progressed and a retinal tear in a previously healthy area was the cause of the retinal detachment. In the other five eyes RD apparently developed from previously treated lesions. Progression of PVD was evident in four out of these five eyes. The untreated eyes had no visible degenerative lesions. During follow up eight eyes developed RD. These eyes had no PVD at the beginning of the study, but showed a partial PVD at the time of the diagnosis of RD. CONCLUSION: Fellow eyes with pre-existing retinal tears and PVDs can go on to retinal detachment in spite of laser prophylactic treatment. When PVD is not detectable or a partial PVD is present, the progression of posterior vitreous separation can account for retinal tears and RDs arising in formerly healthy areas.  (+info)

Acute posterior vitreous detachment: the predictive value of vitreous pigment and symptomatology. (2/53)

AIM: To establish whether the presence of a retinal break can be predicted either by the presence of a positive Shafer's sign (pigment granules in the anterior vitreous) or symptomatology in patients presenting with an acute posterior vitreous detachment (PVD). METHODS: 200 eyes of 200 phakic patients with a symptomatic PVD of less than 1 month's duration underwent documentation of symptomatology and examination of the anterior vitreous for the presence of pigment granules. Indentation ophthalmoscopy was then carried out by an experienced vitreoretinal surgeon with no knowledge of the symptomatology or anterior vitreous gel examination findings. A second prospective group of 115 consecutive patients were assessed in a similar manner before primary rhegmatogenous retinal detachment repair. RESULTS: In 200 eyes presenting with an acute PVD, 25 were found to have an associated retinal break, 23 of which were also Shafer positive. In 115 eyes presenting for retinal detachment repair, 111 had an associated PVD and were found to be Shafer positive. Symptomatology was not predictive of an associated retinal break in the PVD group or in those presenting with a retinal detachment. CONCLUSION: The increased use of Shafer's sign is recommended as a valuable aid in determining which patients require urgent referral for an expert retinal examination. It is not possible to predict those patients with a retinal break secondary to PVD on the basis of symptomatology alone.  (+info)

B-scan ultrasonographic findings in the stages of idiopathic macular hole. (3/53)

PURPOSE: To prospectively evaluate the relationship between the posterior hyaloid membrane (PHM) and the retina in eyes with idiopathic macular hole. METHODS: Ninety-four eyes of 94 consecutive patients with macular hole underwent complete ophthalmologic examination, contact lens biomicroscopy, and B-scan ultrasonography and/or vitreoretinal surgery. RESULTS: In 93 of 94 patients (99%), the relationship between the PHM and posterior retina could be visualized during echographic examinations or at surgery. Among these 93 patients, the PHM was detectable biomicroscopically in 36 (39%). Persistent PHM attachment to the foveola with partial separation of the PHM from the perifoveal retina was evident with ultrasonography in 5 of 6 patients (83%) with stage 1 hole and in 12 of 18 patients (67%) with stage 2 hole. When axial views were included, separation of the PHM from the perifoveal retina was evident in 13 of 13 patients (100%) with stage 1 and stage 2 hole. Separation of the PHM from the fovea and perifoveal retina with attachment to the peripapillary retina was evident with ultrasonography in 65 of 65 patients (100%) with stage 3 macular hole and pseudo-operculum and was evident biomicroscopically in 22 of the 65 patients (34%) in this group. CONCLUSIONS: These findings suggest that high-resolution axial and paraxial ultrasonographic examination directly on the surface of the eye is more sensitive in detecting separation of the PHM from the retina than biomicroscopy in idiopathic macular holes. The perifoveal detachment of the PHM may be involved in the pathogenesis of macular holes.  (+info)

Biomicroscopic vitreous observation using a 3 CCD video camera and a personal computer for image capture and archiving. (4/53)

The purpose of this study is to evaluate the clinical usefulness of a newly developed biomicroscopic vitreous observation system. Vitreous observation was performed in 300 eyes with age- or disease-related vitreous changes using a 3 CCD video camera mounted on a slit-lamp biomicroscope and connected to a personal computer for real-time observation and especially for the capture and archiving of images. Various types of fundus lenses were used to scan the vitreous status systemically from the posterior pole to the vitreous base. This system allowed us to obtain and immediately review the images of the vitreoretinal relationship. The image quality was sufficient for clinical evaluation of the vitreous status. We were able to identify some variations of posterior vitreous detachments and clarify the changes of the vitreoretinal interface in the study eyes. This system is very useful for the dynamic observation and documentation of vitreous images in order to determine the role of vitreous in many vitreoretinal disorders. Furthermore it is more convenient and affordable than previous methods.  (+info)

The use of contrast-enhanced color Doppler ultrasound in the differentiation of retinal detachment from vitreous membrane. (5/53)

OBJECTIVE: To compare the clinical utility of contrast-enhanced color Doppler US in the differentiation of retinal detachment (RD) from vitreous membrane (VM) with that of various conventional US modalities, and to analyze the enhancement patterns in cases showing an enhancement effect. MATERIALS AND METHODS: In 32 eyes examined over a recent two-year period, RD (n=14) and VM (n=18) were confirmed by surgery (n=28) or clinical follow-up (n=4). In all cases, gray-scale, color Doppler, and power Doppler US were performed prior to contrast injection, and after the intravenous injection of Levovist (Schering, Berlin) by hand for 30 seconds at a dose of 2.5 g and a concentration of 300 mg/mL via an antecubital vein, contrast-enhanced color Doppler US was performed. At Doppler US, the diagnostic criterion for RD and VM was whether or not color signals were visualized in membranous structures. RESULTS: Diagnostic accuracy was 78% at gray-scale US, 81% at color Doppler US, 59% at power Doppler US, and 97% at contrast-enhanced color Doppler US. The sensitivity of color Doppler US to color signals in RD increased from 57% to 93% after contrast enhancement. The enhancement patterns observed were signal accentuation (n=3), signal extension (n=2), signal addition (n=3), and new signal visualization (n=5). CONCLUSION: Contrast-enhanced color Doppler US was the most accurate US modality for differentiating RD from VM, showing a significantly increased signal detection rate in RD.  (+info)

Nd:YAG vitreolysis and pars plana vitrectomy: surgical treatment for vitreous floaters. (6/53)

PURPOSE OF STUDY: To determine the efficacy of Nd:YAG vitreolysis and pars plana vitrectomy in the treatment of vitreous floaters. METHODS: This is a single centre retrospective study of 31 patients (42 eyes) who underwent 54 procedures, Nd:YAG vitreolysis or pars plana vitrectomy, for the treatment of vitreous floaters between January 1992 and December 2000. Main outcome measures were percentage symptomatic improvement following treatment and incidence of post-operative complications. Statistical analysis was performed using the Fisher exact test. RESULTS: Posterior vitreous detachment was the primary cause of floaters in all 42 eyes with co-existing vitreous veils in three eyes and asteroid hyalosis in two eyes. Thirty-nine of 42 eyes received Nd:YAG vitreolysis. Thirty-eight percent found Nd:YAG vitreolysis moderately improved their symptoms while 61.5% found no improvement. After an average of 14.7 months follow-up no post-operative complications were recorded. Fifteen eyes underwent a pars plana vitrectomy, one with combined phacoemulsification and posterior chamber implantation and 11 following unsuccessful laser vitreolysis. Pars plana vitrectomy resulted in full resolution of symptoms in 93.3% of eyes. One patient developed a post-operative retinal detachment which was successfully treated leaving the patient with 6/5 VA. CONCLUSION: Patients' symptoms from vitreous floaters are often underestimated resulting in no intervention. This paper shows Nd:YAG vitreolysis to be a safe but only moderately effective primary treatment conferring clinical benefit in one third of patients. Pars plana vitrectomy, while offering superior results, should be reserved for patients who remain markedly symptomatic following vitreolysis, until future studies further clarify its role in the treatment of patients with floaters and posterior vitreous detachment.  (+info)

Imaging vitreous. (7/53)

Purpose Imaging vitreous is a quest to view what is, by design, invisible. This treatise will review significant historical aspects, past and present imaging methodologies, and imaging techniques that are currently in development for future research and clinical applications. Methods Classic and modern histologic techniques, dark-field slit microscopy, clinical slit lamp biomicroscopy, standard and scanning laser ophthalmoscopy, ultrasonography, optical coherence tomography, magnetic resonance and raman spectroscopy, and dynamic light scattering methodologies are presented. Results The best available histologic techniques for imaging vitreous are those that avoid rapid dehydration of vitreous specimens. Dark-field slit microscopy enables in vitro imaging without dehydration or tissue fixatives. Optical coherence tomography enables better in vivo visualization of the vitreo-retinal interface than scanning laser ophthalmoscopy and ultrasonography but does not image the vitreous body. Dynamic light scattering can determine the average sizes of vitreous macromolecules within the vitreous body as well as possibly image the posterior vitreous cortex once detached, while Raman spectroscopy can detect altered vitreous molecules, such as glycated collagen and other proteins in diabetic vitreopathy. Conclusions The inability to adequately image vitreous hinders a more complete understanding of its normal structure and how this changes in aging and disease. The combined use of more than one technique could provide better imaging of vitreous for future investigational and clinical purposes.  (+info)

Clinical, histological and ultrastructural studies of the posterior hyaloid membrane. (8/53)

AIMS: To investigate the histological, immunohistochemical and ultrastructural features of the posterior hyaloid membrane (PHM) in its naturally separated state in patients without previous surgery and slit-lamp documentation of antemortem posterior vitreous detachment (PVD). METHODS: A prospective study was commenced in 1992 to recruit patients with physiological PVD from an unselected group of general medical inpatients and ascertain the prevalence of PVD. Postmortem specimens subsequently available were studied to analyse the clinicopathological correlation and processed using standard techniques for histology, immunohistochemistry and electron microscopy. RESULTS: Eighty-five patients were examined with ages ranging from 68 to 98 yrs (mean 83.4 yrs). The posterior hyaloid membrane had clearly separated from the retina in 66% of eyes. Twenty-nine eyes from 15 patients were subsequently studied pathologically. The posterior hyaloid membrane exhibited a uniform cellular component, most densely populated around the Weiss' ring. The cells were characterised by oval or round nuclei, indistinct cytoplasm and were only seen within, or abutting, the weakly eosinophilic posterior hyaloid membrane. The posterior aspect of the posterior hyaloid membrane showed a convoluted appearance staining lightly with haematoxylin and eosin. The detached posterior hyaloid membrane exhibited focal positivity for GFAP and type IV collagen. Electron microscopy demonstrates both fibres and basement membrane associated with the cellular component including hemi-desmosome attachment plaques between the cells and basement membrane. CONCLUSIONS: This study illustrates some of the structural differences between the posterior hyaloid membrane and the cortical vitreous gel it envelopes and demonstrates the presence of cells intimately associated with the posterior hyaloid membrane in its naturally separated state. We propose the cellular population integral to the PHM to be designated as laminocytes in order to emphasise their type IV collagen/basement membrane association and planar array within the membrane which separates at posterior vitreous detachment.  (+info)

Vitreous detachment, also known as posterior vitreous detachment (PVD), is a common age-related eye condition characterized by the separation of the vitreous gel from the retina. The vitreous is a clear, gel-like substance that fills the space between the lens and the retina in the eye. As we age, the vitreous may change in consistency, becoming more liquefied, leading to the formation of pockets of liquid within the gel.

In vitreous detachment, the posterior part of the vitreous closest to the retina begins to pull away from the retinal surface due to the shrinkage and liquefaction of the vitreous gel. This separation can cause symptoms such as floaters (spots or strands in the field of vision), flashes of light, or a decrease in vision sharpness. While vitreous detachment is typically not a serious condition on its own, it can sometimes lead to complications like retinal tears or retinal detachment, which require immediate medical attention.

Entoptic vision refers to the visual perception of internal structures or processes within the eye. These perceptions are not derived from external stimuli, but rather from the physiological responses of the eye itself. Examples of entoptic phenomena include floaters (small spots or strands that move across the visual field), blue field illusion (the appearance of white or dark dots in a blue field of view), and Purkinje trees (the pattern of light reflections from the cornea and lens). Entoptic phenomena are often used in scientific research to study the structure and function of the eye.

The vitreous body, also known simply as the vitreous, is the clear, gel-like substance that fills the space between the lens and the retina in the eye. It is composed mainly of water, but also contains collagen fibers, hyaluronic acid, and other proteins. The vitreous helps to maintain the shape of the eye and provides a transparent medium for light to pass through to reach the retina. With age, the vitreous can become more liquefied and may eventually separate from the retina, leading to symptoms such as floaters or flashes of light.

A retinal perforation is a full-thickness break or hole in the retina, which is the light-sensitive tissue that lines the inner surface of the eye. This condition can lead to a serious complication called retinal detachment, where the retina separates from the underlying tissue, potentially resulting in vision loss if not promptly treated. Retinal perforations may be caused by trauma, certain eye conditions, or invasive eye procedures. Immediate medical attention is required for retinal perforations to prevent further damage and preserve vision.

An epiretinal membrane, also known as a macular pucker or cellophane maculopathy, is a thin and transparent layer of tissue that forms over the macula (the central part of the retina responsible for sharp, detailed vision) in the eye. This membrane can contract and wrinkle the macula, distorting central vision.

Epiretinal membranes are typically caused by the migration and proliferation of glial cells or other cell types onto the surface of the retina following retinal injury, inflammation, or aging. In some cases, they may be associated with other eye conditions such as diabetic retinopathy, retinal vein occlusion, or age-related macular degeneration.

Mild epiretinal membranes may not require treatment, but if the distortion of vision is significant, a vitrectomy surgery may be recommended to remove the membrane and improve visual acuity.

A vitrectomy is a surgical procedure that involves the removal of some or all of the vitreous humor, which is the clear gel-like substance filling the center of the eye. This surgery is often performed to treat various retinal disorders such as diabetic retinopathy, retinal detachment, macular hole, and vitreous hemorrhage.

During a vitrectomy, the ophthalmologist makes small incisions in the sclera (the white part of the eye) to access the vitreous cavity. The surgeon then uses specialized instruments to remove the cloudy or damaged vitreous and may also repair any damage to the retina or surrounding tissues. Afterward, a clear saline solution is injected into the eye to maintain its shape and help facilitate healing.

In some cases, a gas bubble or silicone oil may be placed in the eye after the vitrectomy to help hold the retina in place while it heals. These substances will gradually be absorbed or removed during follow-up appointments. The body naturally produces a new, clear vitreous to replace the removed material over time.

Vitrectomy is typically performed under local anesthesia and may require hospitalization or outpatient care depending on the individual case. Potential risks and complications include infection, bleeding, cataract formation, retinal detachment, and increased eye pressure. However, with proper care and follow-up, most patients experience improved vision after a successful vitrectomy procedure.

Retinal detachment is a serious eye condition that occurs when the retina, a thin layer of tissue at the back of the eye responsible for processing light and sending visual signals to the brain, pulls away from its normal position. This can lead to significant vision loss or even blindness if not promptly treated. Retinal detachment can be caused by various factors such as aging, trauma, eye disease, or an inflammatory condition. Symptoms of retinal detachment may include sudden flashes of light, floaters, a shadow in the peripheral vision, or a curtain-like covering over part of the visual field. Immediate medical attention is necessary to prevent further damage and preserve vision.

Eye diseases are a range of conditions that affect the eye or visual system, causing damage to vision and, in some cases, leading to blindness. These diseases can be categorized into various types, including:

1. Refractive errors: These include myopia (nearsightedness), hyperopia (farsightedness), astigmatism, and presbyopia, which affect the way light is focused on the retina and can usually be corrected with glasses or contact lenses.
2. Cataracts: A clouding of the lens inside the eye that leads to blurry vision, glare, and decreased contrast sensitivity. Cataract surgery is the most common treatment for this condition.
3. Glaucoma: A group of diseases characterized by increased pressure in the eye, leading to damage to the optic nerve and potential blindness if left untreated. Treatment includes medications, laser therapy, or surgery.
4. Age-related macular degeneration (AMD): A progressive condition that affects the central part of the retina called the macula, causing blurry vision and, in advanced stages, loss of central vision. Treatment may include anti-VEGF injections, laser therapy, or nutritional supplements.
5. Diabetic retinopathy: A complication of diabetes that affects the blood vessels in the retina, leading to bleeding, leakage, and potential blindness if left untreated. Treatment includes laser therapy, anti-VEGF injections, or surgery.
6. Retinal detachment: A separation of the retina from its underlying tissue, which can lead to vision loss if not treated promptly with surgery.
7. Amblyopia (lazy eye): A condition where one eye does not develop normal vision, often due to a misalignment or refractive error in childhood. Treatment includes correcting the underlying problem and encouraging the use of the weaker eye through patching or other methods.
8. Strabismus (crossed eyes): A misalignment of the eyes that can lead to amblyopia if not treated promptly with surgery, glasses, or other methods.
9. Corneal diseases: Conditions that affect the transparent outer layer of the eye, such as keratoconus, Fuchs' dystrophy, and infectious keratitis, which can lead to vision loss if not treated promptly.
10. Uveitis: Inflammation of the middle layer of the eye, which can cause vision loss if not treated promptly with anti-inflammatory medications or surgery.

A Vitreous Hemorrhage is a medical condition where there is bleeding into the vitreous cavity of the eye. The vitreous cavity is the space in the eye that is filled with a clear, gel-like substance called the vitreous humor. This substance helps to maintain the shape of the eye and transmit light to the retina.

When a vitreous hemorrhage occurs, blood cells from the bleeding mix with the vitreous humor, causing it to become cloudy or hazy. As a result, vision can become significantly impaired, ranging from mildly blurry to complete loss of vision depending on the severity of the bleed.

Vitreous hemorrhages can occur due to various reasons such as trauma, retinal tears or detachments, diabetic retinopathy, age-related macular degeneration, and other eye conditions that affect the blood vessels in the eye. Treatment for vitreous hemorrhage depends on the underlying cause and may include observation, laser surgery, or vitrectomy (a surgical procedure to remove the vitreous humor and stop the bleeding).

I'm sorry for any confusion, but "Hyaluronoglucosaminidase" appears to be a made-up term or a typographical error. The correct term related to hyaluronic acid metabolism is "hyaluronidase," which is an enzyme that degrades hyaluronic acid, a component of the extracellular matrix in various tissues. If you meant to ask about this enzyme or its functions, I'd be happy to provide more information on that. However, if "Hyaluronoglucosaminidase" is intended to represent another medical term, could you please clarify so I can provide an accurate and helpful response?

The macula lutea, often simply referred to as the macula or fovea centralis, is a part of the eye that is responsible for central vision and color perception. It's located in the center of the retina, the light-sensitive tissue at the back of the eye. The macula contains a high concentration of pigments called xanthophylls, which give it a yellowish color and protect the photoreceptor cells in this area from damage by blue light.

The central part of the macula is called the fovea, which is a small depression that contains only cones, the photoreceptor cells responsible for color vision and high visual acuity. The fovea is surrounded by the parafovea and the perifovea, which contain both cones and rods, the photoreceptor cells responsible for low-light vision and peripheral vision.

Damage to the macula can result in a loss of central vision and color perception, a condition known as age-related macular degeneration (AMD), which is a leading cause of blindness in older adults. Other conditions that can affect the macula include macular edema, macular holes, and macular pucker.

Fibrinolysin is defined as a proteolytic enzyme that dissolves or breaks down fibrin, a protein involved in the clotting of blood. This enzyme is produced by certain cells, such as endothelial cells that line the interior surface of blood vessels, and is an important component of the body's natural mechanism for preventing excessive blood clotting and maintaining blood flow.

Fibrinolysin works by cleaving specific bonds in the fibrin molecule, converting it into soluble degradation products that can be safely removed from the body. This process is known as fibrinolysis, and it helps to maintain the balance between clotting and bleeding in the body.

In medical contexts, fibrinolysin may be used as a therapeutic agent to dissolve blood clots that have formed in the blood vessels, such as those that can occur in deep vein thrombosis or pulmonary embolism. It is often administered in combination with other medications that help to enhance its activity and specificity for fibrin.

Macular edema is a medical condition characterized by the accumulation of fluid in the macula, a small area in the center of the retina responsible for sharp, detailed vision. This buildup of fluid causes the macula to thicken and swell, which can distort central vision and lead to vision loss if not treated promptly. Macular edema is often a complication of other eye conditions such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, or uveitis. It's important to note that while macular edema can affect anyone, it is more common in people with certain medical conditions like diabetes.

Optical coherence tomography (OCT) is a non-invasive imaging technique that uses low-coherence light to capture high-resolution cross-sectional images of biological tissues, particularly the retina and other ocular structures. OCT works by measuring the echo time delay of light scattered back from different depths within the tissue, creating a detailed map of the tissue's structure. This technique is widely used in ophthalmology to diagnose and monitor various eye conditions such as macular degeneration, diabetic retinopathy, and glaucoma.

Visual acuity is a measure of the sharpness or clarity of vision. It is usually tested by reading an eye chart from a specific distance, such as 20 feet (6 meters). The standard eye chart used for this purpose is called the Snellen chart, which contains rows of letters that decrease in size as you read down the chart.

Visual acuity is typically expressed as a fraction, with the numerator representing the testing distance and the denominator indicating the smallest line of type that can be read clearly. For example, if a person can read the line on the eye chart that corresponds to a visual acuity of 20/20, it means they have normal vision at 20 feet. If their visual acuity is 20/40, it means they must be as close as 20 feet to see what someone with normal vision can see at 40 feet.

It's important to note that visual acuity is just one aspect of overall vision and does not necessarily reflect other important factors such as peripheral vision, depth perception, color vision, or contrast sensitivity.

The retina is the innermost, light-sensitive layer of tissue in the eye of many vertebrates and some cephalopods. It receives light that has been focused by the cornea and lens, converts it into neural signals, and sends these to the brain via the optic nerve. The retina contains several types of photoreceptor cells including rods (which handle vision in low light) and cones (which are active in bright light and are capable of color vision).

In medical terms, any pathological changes or diseases affecting the retinal structure and function can lead to visual impairment or blindness. Examples include age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinitis pigmentosa among others.

An intravitreal injection is a medical procedure in which medication is delivered directly into the vitreous cavity of the eye, which is the clear, gel-like substance that fills the space between the lens and the retina. This type of injection is typically used to treat various eye conditions such as age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, and uveitis. The medication administered in intravitreal injections can help to reduce inflammation, inhibit the growth of new blood vessels, or prevent the formation of abnormal blood vessels in the eye.

Intravitreal injections are usually performed in an outpatient setting, and the procedure typically takes only a few minutes. Before the injection, the eye is numbed with anesthetic drops to minimize discomfort. The medication is then injected into the vitreous cavity using a small needle. After the injection, patients may experience some mild discomfort or a scratchy sensation in the eye, but this usually resolves within a few hours.

While intravitreal injections are generally safe, there are some potential risks and complications associated with the procedure, including infection, bleeding, retinal detachment, and increased intraocular pressure. Patients who undergo intravitreal injections should be closely monitored by their eye care provider to ensure that any complications are promptly identified and treated.

Myopia, also known as nearsightedness, is a common refractive error of the eye. It occurs when the eye is either too long or the cornea (the clear front part of the eye) is too curved. As a result, light rays focus in front of the retina instead of directly on it, causing distant objects to appear blurry while close objects remain clear.

Myopia typically develops during childhood and can progress gradually or rapidly until early adulthood. It can be corrected with glasses, contact lenses, or refractive surgery such as LASIK. Regular eye examinations are essential for people with myopia to monitor any changes in their prescription and ensure proper correction.

While myopia is generally not a serious condition, high levels of nearsightedness can increase the risk of certain eye diseases, including cataracts, glaucoma, retinal detachment, and myopic degeneration. Therefore, it's crucial to manage myopia effectively and maintain regular follow-ups with an eye care professional.

An injection is a medical procedure in which a medication, vaccine, or other substance is introduced into the body using a needle and syringe. The substance can be delivered into various parts of the body, including into a vein (intravenous), muscle (intramuscular), under the skin (subcutaneous), or into the spinal canal (intrathecal or spinal).

Injections are commonly used to administer medications that cannot be taken orally, have poor oral bioavailability, need to reach the site of action quickly, or require direct delivery to a specific organ or tissue. They can also be used for diagnostic purposes, such as drawing blood samples (venipuncture) or injecting contrast agents for imaging studies.

Proper technique and sterile conditions are essential when administering injections to prevent infection, pain, and other complications. The choice of injection site depends on the type and volume of the substance being administered, as well as the patient's age, health status, and personal preferences.

Scanning electron microscopy (SEM) is a type of electron microscopy that uses a focused beam of electrons to scan the surface of a sample and produce a high-resolution image. In SEM, a beam of electrons is scanned across the surface of a specimen, and secondary electrons are emitted from the sample due to interactions between the electrons and the atoms in the sample. These secondary electrons are then detected by a detector and used to create an image of the sample's surface topography. SEM can provide detailed images of the surface of a wide range of materials, including metals, polymers, ceramics, and biological samples. It is commonly used in materials science, biology, and electronics for the examination and analysis of surfaces at the micro- and nanoscale.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

MedlinePlus is not a medical term, but rather a consumer health website that provides high-quality, accurate, and reliable health information, written in easy-to-understand language. It is produced by the U.S. National Library of Medicine, the world's largest medical library, and is widely recognized as a trusted source of health information.

MedlinePlus offers information on various health topics, including conditions, diseases, tests, treatments, and wellness. It also provides access to drug information, medical dictionary, and encyclopedia, as well as links to clinical trials, medical news, and patient organizations. The website is available in both English and Spanish and can be accessed for free.

Scleral buckling is a surgical procedure used to treat retinal detachment, a serious eye condition that can cause vision loss. In this procedure, the sclera (the white outer coat of the eye) is "buckled" or indented with a piece of silicone rubber or sponge material. This brings the detached retina into contact with the wall of the eye, allowing the retina to reattach and heal. The buckle is usually left in place permanently. Scleral buckling has been a standard treatment for retinal detachment for many years and is often combined with vitrectomy or cryotherapy to improve outcomes.

In the context of medical terminology, "light" doesn't have a specific or standardized definition on its own. However, it can be used in various medical terms and phrases. For example, it could refer to:

1. Visible light: The range of electromagnetic radiation that can be detected by the human eye, typically between wavelengths of 400-700 nanometers. This is relevant in fields such as ophthalmology and optometry.
2. Therapeutic use of light: In some therapies, light is used to treat certain conditions. An example is phototherapy, which uses various wavelengths of ultraviolet (UV) or visible light for conditions like newborn jaundice, skin disorders, or seasonal affective disorder.
3. Light anesthesia: A state of reduced consciousness in which the patient remains responsive to verbal commands and physical stimulation. This is different from general anesthesia where the patient is completely unconscious.
4. Pain relief using light: Certain devices like transcutaneous electrical nerve stimulation (TENS) units have a 'light' setting, indicating lower intensity or frequency of electrical impulses used for pain management.

Without more context, it's hard to provide a precise medical definition of 'light'.

I'm sorry for any confusion, but "Gross Domestic Product" (GDP) is an economic term, not a medical one. GDP is the total monetary or market value of all the finished goods and services produced within a country's borders in a specific time period. It serves as a comprehensive measure of a nation’s overall economic activity.

If you have any medical questions or terms you would like defined, I would be happy to help!

A posterior vitreous detachment (PVD) is a condition of the eye in which the vitreous membrane separates from the retina. It ... Posterior Vitreous Detachment is diagnosed via dilated eye examination. For some patients the vitreous gel is extremely clear ... "Posterior Vitreous Detachment". American Society of Retinal Specialists. ASRS. Retrieved July 11, 2017. "Posterior Vitreous ... The risk of retinal tears and detachment associated with vitreous detachment is higher in patients with myopic retinal ...
Vitreous detachment Aqueous humor Sobotta, Johannes (2011). Sobotta : atlas of human anatomy (15th ed.). München: Elsevier/ ... The vitreous fluid, along with supporting the lens, also functions in maintaining the shape of the entire vitreous chamber and ... This chamber is filled with a thick, clear gel-like substance called the vitreous humor (also vitreous body). The humor plays a ... The vitreous chamber is the largest of the three chambers in the eye and is located behind the lens and in front of the optic ...
Posterior vitreous detachment (PVD) does not directly threaten vision, but its cases are monitored with increasing interest, ... Hilford, D.; Hilford, M.; Mathew, A.; Polkinghorne, P.J. (2009). "Posterior vitreous detachment following cataract surgery". ... and vitreous' communication with the anterior chamber (due to posterior capsule rupture). The risk of vitreous infection is at ... People with retinal detachment may be scheduled for a combined vitreo-retinal procedure, along with PCIOL implantation. People ...
Posterior vitreous detachment (PVD) may occur but does not directly threaten vision. Some people develop a posterior capsular ... Hilford D, Hilford M, Mathew A, Polkinghorne PJ (June 2009). "Posterior vitreous detachment following cataract surgery". Eye. ... This provides a barrier between the front and back chambers of the eye, and prevents the vitreous from moving forwards. It also ... Patients who have had cataract surgery are at an increased risk of developing rhegmatogenous retinal detachment (RRD)-the most- ...
... cells converge in the macular area as the vitreous ages and pulls away in posterior vitreous detachment (PVD). PVD can create ... It has been estimated that Posterior vitreous detachment (PVD) occurs in over 75 percent of the population over age 65, that ... Johnson MW (2005). "Perifoveal vitreous detachment and its macular complications". Trans Am Ophthalmol Soc. 103: 537-67. PMC ... Usually the vitreous is replaced at the same time with clear (BSS) fluid, in a vitrectomy. Surgery is not usually recommended ...
... detachment is typically associated with blunt ocular trauma. Myron Yanoff; Jay S Duker; James J Augsburger; et al ... The vitreous membrane is more firmly attached to the retina anteriorly at the vitreous base. The vitreous membrane does not ... The vitreous base is an area in the fundus of the eye in which the vitreous membrane, neural retina, and pigment epithelium all ... normally detach from the vitreous base, although it can be detached with extreme trauma. ...
Complications include detachment of the vitreous or retina, and glaucoma. Babies are rarely born with aphakia. Occurrence most ... Glaucoma: Secondary angle closure glaucoma may occur due to vitreous prolapse. Retinal detachment Aphakic bullous keratopathy ... Sowka, Joseph W. (November 2002). "Pupil block glaucoma from traumatic vitreous prolapse in a patient with posterior chamber ...
Posterior vitreous detachment accounts for 3.7-11.7% of vitreous hemorrhage cases. Less common causes of vitreous hemorrhage ... Vitreous hemorrhage is the extravasation, or leakage, of blood into the areas in and around the vitreous humor of the eye. The ... In cases of vitreous hemorrhage due to detached retina, long-standing vitreous hemorrhage with a duration of more than 2-3 ... "Vitreous Hemorrhage." CRS - Eye Advisor (2010): 1. Health Source - Consumer Edition. Web. 29 November 2011. "Vitreous ...
3. Vitreoretinal surgery is required for nonresolving vitreous haemorrhage and tractional retinal detachment. •If active TB is ... Eye floaters may develop indicating the possibility of the progression of the disease to a point where retinal detachment is a ... These are not normally recognized until the inflammation results in vitreous hemorrhage. This disease has been found to affect ... Some may develop symptoms such as floaters, blurring vision, or even gross diminution of vision due to massive vitreous ...
Peripheral (posterior) vitreous detachment occurs when the gel around the eye separates from the retina. This can naturally ... It is most commonly associated with: posterior vitreous detachment migraine aura (ocular migraine / retinal migraine) migraine ... "Retinal detachment - Symptoms and causes - Mayo Clinic". Mayo Clinic. Retrieved 30 August 2019. Morrow, Nicole C.; Chung, ... Photopsia can present as retinal detachment when examined by an optometrist or ophthalmologist. However, it can also be a sign ...
... vitreous detachment). If the vitreous pulls away from the retina, it is known as a vitreous detachment. As the human body ages ... Vitreous fluid or "liquid vitreous" is the liquid component of the vitreous gel, found after a vitreous detachment. It is not ... Posterior vitreous detachment: Once liquid vitreous enters the sub-hyaloid space between the vitreous cortex and the retina, it ... The vitreous humour is in contact with the vitreous membrane overlying the retina. Collagen fibrils attach the vitreous at the ...
Cibis, P. A. (1965). Treatment of retinal detachment by injection of silicon oil into the vitreous body. Bericht über die ... retinal detachment and breaks without detachment. McPherson, A. (Ed): New and Controversial Aspects of Retinal Detachment. 164 ... retinal detachment and breaks without detachment. New and controversial aspects of retinal detachment. International symposium ... The surgical techniques he pioneered and developed, involved directly operating on the vitreous to repair retinal detachments. ...
However, some patients may present with the symptoms of a posterior vitreous detachment or serous retinal detachment. This is ... Optic pits are important because they are associated with posterior vitreous detachments (PVD) and even serous retinal ... Optic pits have been associated with serous retinal detachments in up to as many as 50% of all cases. These detachments may ... If serous macular detachment occurs, a patient's visual acuity may become as poor as 20/200 or worse. Treatment for optic pit- ...
It can likely progress to loss of vision in late stages due to vitreous hemorrhage or retinal detachment. Sickle cell disease ... Indications include longstanding vitreous haemorrhage, vitreous haemorrhage in both eyes, vitreous haemorrhage in patients with ... Sudden loss of vision may occur due to retinal artery occlusion, vitreous hemorrhage or retinal detachment. Intravascular ... Stage of vitreous hemorrhage. Peripheral neovascular tufts bleed and cause vitreous hemorrhage. Stage of vitreoretinal traction ...
In addition to typical changes in the vitreous, retinal detachment occurs in some and cataract is another complication. "Wagner ... In 1938 Hans Wagner described 13 members of a Canton of Zurich family with a peculiar lesion of the vitreous and retina. Ten ... Diagnosis is based on fundus examination that reveals an empty vitreous with vitreoretinal degeneration in similar picture to ... "vitreous" jelly grabs too tightly to the already weak retina and pulls it away. ...
Common adverse effects of the eye formulation include conjunctival hemorrhage, eye pain, cataract, vitreous detachment, ...
... injuries commonly observed in this region are vitreous hemorrhage, traumatic macular holes, retinal detachment, and optic nerve ... Collectively, patients who experienced choroidal hemorrhage, perforated or penetrated globes, retinal detachment, traumatic ... Zone III: this zone contains the vitreous cavity, retina, and optic nerve; ...
This leads to posterior vitreous detachment, in which the vitreous membrane is released from the sensory retina. During this ... and this has shown to be successful on vitreous opacities obtained during vitrectomy and in rabbits. A vitreous detachment ... or between the vitreous and the retina. The vitreous humour, or vitreous body, is a jelly-like, transparent substance that ... within the eye's vitreous humour ("the vitreous"), which is normally transparent, or between the vitreous and retina. They can ...
The vitreous gel undergoes liquefaction (posterior vitreous detachment or PVD) and its opacities - visible as floaters - ... The cornea is transparent and more curved and is linked to the larger posterior segment, composed of the vitreous, retina, ... The vitreous body is a clear substance composed of water and proteins, which give it a jelly-like and sticky composition. Each ... and the vitreous body, a jelly-like substance, behind the lens, filling the entire posterior cavity. The aqueous humour is a ...
Ringside doctors examination discovered Takehara had posterior vitreous detachment which progressed into retinal detachment and ...
A retinal detachment is commonly but not always preceded by a posterior vitreous detachment which gives rise to these symptoms ... Although most posterior vitreous detachments do not progress to retinal detachments, those that do produce the following ... Occasionally, posterior vitreous detachment, injury or trauma to the eye or head may cause a small tear in the retina. The tear ... There are 4 main types of retinal detachment: Rhegmatogenous retinal detachment - A rhegmatogenous retinal detachment occurs ...
describes a 1-year, 3 month old boy of Chinese descent who had retinal detachment and vitreous and lens opacity. He had no ... "Exome sequencing identifies a de novo mutation of CTNNB1 gene in a patient mainly presented with retinal detachment, lens and ... Retinal Detachment, Polydactyly". Frontiers in Pediatrics. 8: 575673. doi:10.3389/fped.2020.575673. PMC 7793974. PMID 33425807 ... vitreous opacities, microcephaly, and developmental delay: Case report and literature review". Medicine. 96 (20): e6914. doi: ...
... progressive retinal atrophy and posterior vitreous detachment. Non-eye breed related conditions which may affect a Parson are ...
During rhegmatogenous retinal detachment, fluid from the vitreous humor enters a retinal hole. The mechanisms by which retinal ... Grade A is characterized by the appearance of vitreous haze and RPE cells in the vitreous. Grade B is characterized by ... All these finally lead to secondary retinal detachment after primary retinal detachment surgery. A number of studies have also ... quadrants of detachment) + 0.83 × (vitreous haemorrhage) + 23 × (previous cryotherapy) 1 is added if the risk factor is present ...
... retinal detachment, and vitreous hemorrhage. Foot damage. Diabetes mellitus can lead to poor vascular blood flow to the ...
An adverse effect of this is retinal detachment (and vitreous hemorrhage), also there is no systemic beneficial effect for ... Retinal detachment occurs in up to 29% of affected eyes, repair being most effective with endolaser and silicone oil ... Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be ... Also intravitreal injections, an injection of medicine into the vitreous near the retina, of foscarnet in concomitance with ...
... clear lens extraction may also cause premature posterior vitreous detachment and retinal detachment. As opposed to the more ...
... clear lens extraction may also cause premature posterior vitreous detachment and retinal detachment. In some people with very ...
... tractional retinal detachments, and posterior vitreous detachments. Pan retinal photocoagulation is a type of photocoagulation ... It is used for preventing or treating vitreous loss during cataract or corneal surgery, or to remove misplaced vitreous in ... Retinal detachment repair Ignipuncture is an obsolete procedure that involves cauterization of the retina with a very hot, ... A scleral buckle is used in the repair of a retinal detachment to indent or "buckle" the sclera inward, usually by sewing a ...
It works by dissolving the proteins that link the vitreous to the macula, resulting in posterior detachment of the vitreous ... is currently being studied in clinical trials and data indicate that it is able to induce posterior vitreous detachment in ... "Mechanism of inactivation of ocriplasmin in porcine vitreous". Biophysical Chemistry. 165-166: 30-8. doi:10.1016/j.bpc.2012.03. ...

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