Atrophy and shriveling of the SKIN of the VULVA that is characterized by the whitish LICHEN SCLEROSUS appearance, inflammation, and PRURITUS.
A chronic inflammatory mucocutaneous disease usually affecting the female genitalia (VULVAR LICHEN SCLEROSUS) and BALANITIS XEROTICA OBLITERANS in males. It is also called white spot disease and Csillag's disease.
Complex pain syndrome with unknown etiology, characterized by constant or intermittent generalized vulva pain (Generalized vulvodynia) or localized burning sensations in the VESTIBULE area when pressure is applied (Vestibulodynia, or Vulvar Vestibulitis Syndrome). Typically, vulvar tissue with vulvodynia appears normal without infection or skin disease. Vulvodynia impacts negatively on a woman's quality of life as it interferes with sexual and daily activities.
Any of a group of plants formed by a symbiotic combination of a fungus with an algae or CYANOBACTERIA, and sometimes both. The fungal component makes up the bulk of the lichen and forms the basis for its name.
Pathological processes of the VULVA.
An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
Tumors or cancer of the VULVA.
A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.
The external genitalia of the female. It includes the CLITORIS, the labia, the vestibule, and its glands.
A condition in which the FORESKIN cannot be retracted to reveal the GLANS PENIS. It is due to tightness or narrowing of the foreskin opening.
Pathological processes involving the PENIS or its component tissues.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)

A clinico-pathological study of vulval dermatoses. (1/15)

A long-term review of 108 women suffering from various forms of vulval dermatosis is described and a detailed analysis of those with chronic hypertrophic vulvitis, lichen sclerosus et atrophicus, and neurodermatitis is made. One case of neurodermatitis and two cases of lichen sclerosus progressed to carcinoma but no case of chronic hypertrophic vulvitis became malignant. It is possible that vulval dermatoses occur more commonly in the nulliparous than in the parous women and there is a slight preponderance of women who are blood group A. It is suggested that the term "leukoplakia" should be abandoned and that vulval lesions should be described in precise and meaningful histological terms.  (+info)

Mucinous metaplasia of the vulva in a case of lichen sclerosus. A case report. (2/15)

Mucinous metaplasia of the genital area is a rare condition characterised by the emergence of mucin containing cells in stratified squamous epithelium. This report describes a unique case of benign mucinous metaplasia of the vulva associated with lichen sclerosus in a 60 year old woman. Histopathology revealed cervical type metaplasia with otherwise typical lichen sclerosus. This report discusses the pathogenesis and differential diagnosis of mucinous epithelium.  (+info)

The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus. (3/15)

Lichen sclerosus (LS) is considered to have an immunogenetic background. Several small studies, using serological typing, have reported that HLA-DR11, DR12, and DQ7 were increased in LS, with DR17 less frequent. This study aimed to validate and detect new HLA-DR and DQ associations with LS in females and its characteristic clinical parameters. The cases, 187 female LS patients, and 354 healthy controls were all UK North Europeans. PCR-sequence specific primers method was applied to genotype the HLA-DR, DQ polymorphisms that correspond to 17 serologically defined DR and seven DQ antigens. Statistical analysis was performed with two-tailed Fisher's exact test with Bonferroni adjustment (p value after Bonferrroni adjustment, Pc). We found increased frequency of DRB1*12 (DR12) (11.2%vs 2.5%, pc < 0.01) and the haplotype DRB1*12/DQB1*0301/04/09/010 (11.2%vs 2.5%, p < 0.001, pc < 0.05), and a lower frequency of DRB1*0301/04 (DR17) (11.8%vs 25.8%, pc < 0.01) and the haplotype DRB1*03/DQB1*02DRB1*0301/DQB1*0201/02/03 (11.2%vs 24.6%, pc < 0.0001) in patients compared with controls. HLA DR and DQ antigens were not associated with time of onset of disease, site of involvement, structural changes of genitals, and response to treatment with potent topical steroids. In conclusion, HLA-DR and DQ antigens or their haplotypes appear to be involved in both susceptibility to and protection from LS.  (+info)

In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: new insights in histology and aetiology. (4/15)

BACKGROUND: Differentiated vulvar intraepithelial neoplasia (VIN) is presumed to be the precursor of invasive squamous cell carcinoma (SCC) of the vulva. It is commonly assumed that differentiated VIN is related to lichen sclerosus (LS). However, evidence for this is limited to a small number of studies describing epithelial alterations adjacent to vulvar SCC. AIM: To study the histology and human papillomavirus (HPV) status in patients with a history of both LS and VIN without coexistent SCC. METHODS: Original biopsy specimens and surgical specimens of patients retrieved from the pathology files were revised for the presence of LS, VIN and (early) invasive SCC, specifically focused on the two different types of VIN: differentiated and undifferentiated. Thereafter, VIN lesions were tested for the presence of HPV DNA. RESULTS: Twenty-seven patients fulfilled the criteria for LS and VIN without SCC. In all 27 patients, LS was found to be related to undifferentiated VIN. Grading yielded the following results: VIN 1 (n=10), VIN 2 (n=11) and VIN 3 (n=6). Additionally, VIN lesions from 26 patients could be tested for the presence of HPV DNA. HPV DNA, predominantly type 16, was present in 8 (31%) of them. Seven of these eight patients had VIN 2 or 3. During follow-up, three patients progressed to (early) invasive carcinoma. In two of these patients, differentiated VIN was observed overlying early invasive SCC. CONCLUSIONS: VIN related to LS without coexisting SCC is likely to be undifferentiated, in contrast to what was previously thought. HPV DNA was demonstrated in 31% of the lesions, and was strongly related to high-grade VIN.  (+info)

Unexpectedly high frequency of genital involvement in women with clinical and histological features of oral lichen planus. (5/15)

The main aims of this cross-sectional study were: (i) to assess the frequency of genital (vulval) lichen planus (VLP) and vulval lichen sclerosus (VLS) in women affected with oral lichen planus (OLP), regardless of the genital symptoms reported; and (ii) to verify whether any demographic, clinical, or histological features of OLP are associated with a higher risk of vulvo-vaginal involvement. Fifty-five women, presenting OLP, consecutively underwent gynaecological examination and, if they demonstrated positive clinical signs of VLP, underwent biopsy. After a drop-out of 14 subjects, 31/41 (75.6%) were found to have signs of genital involvement, of which 13/31 (44.0%) were asymptomatic. Following genital biopsy, 27/31 (87.1%) had histologically confirmed VLP or VLS. Following both univariate and multivariate statistical analyses, no significant association was found between gynaecological concomitance and demographic, clinical, histological features of OLP. This unpredictably common genital involvement in females with OLP emphasizes the importance of routinely performing both oral and gynaecological examinations, to facilitate an early and correct therapeutic approach.  (+info)

Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. (6/15)

Lichen sclerosus is a chronic relapsing disease, usually treated with ultra-potent corticosteroids. As immunological alterations are considered important aetiopathogenetic factors in lichen sclerosus, the new immunomodulating topical agents, such as tacrolimus and pimecrolimus, have been employed sporadically as alternative therapies. The aim of this study was to evaluate the therapeutic effects of tacrolimus 0.1% ointment in lichen sclerosus in 11 patients unresponsive or poorly responsive to previous treatments. Tacrolimus 0.1% ointment was applied twice daily for 6 weeks, then tapered over a further 6 weeks. Symptoms and objective parameters were evaluated and quantified at the start, after 6 weeks, at the end of the topical treatment, and at follow-up visits. Improvement or remission of symptoms was observed in the patients who completed the study, while objective parameters were poorly influenced and often were not related to symptom behaviour. Topical tacrolimus can be considered an alternative treatment for lichen sclerosus.  (+info)

Single base instability is promoted in vulvar lichen sclerosus. (7/15)

Single base substitution mutations in codons 248 and 273 of TP53 and codon 12 Kirsten-ras (KRAS) are commonly found in human carcinomas. To determine whether these mutations also occur in normal and inflamed tissues from which carcinomas arise, we utilized the ultra-sensitive polymerase chain reaction/restriction endonuclease/ligase chain reaction mutation assay. Ninety samples of genital skin, including lichen sclerosus (LS) affected skin, adjacent normal and non-adjacent normal, were assayed. Mutations were detected in 103 of 349 assays and consisted of KRAS G34A, G34T, G35A, and TP53 C742T, G818C, C817T, and G818A mutations. Mutant prevalence varied from 1 to 20 per 10(6) wild-type cells. Mutations occurred significantly more frequently in LS (78/224 (35%)) than adjacent normal (20/88 (23%)) and non-adjacent normal genital skin (5/38 (13%)). KRAS G34A mutation was relatively common to all classes of specimen, whereas TP53 gene C742T and G818C mutations were significantly more frequent in LS than normal genital skin. In matched samples, immunohistochemistry evaluation of p53 protein expression revealed the presence of epidermal p53 clones in LS whose presence and number significantly correlated with the presence of TP53 C742T and G818C mutations. Based on these results, it appears oncogenic point mutations occur in normal genital skin, and are selected for in LS.  (+info)

Non-neoplastic epithelial disorders of the vulva. (8/15)

Lichen sclerosus, lichen planus, and lichen simplex chronicus are three of the most common non-neoplastic epithelial disorders of the vulva. Lichen sclerosus is characterized by intense vulvar itching and can affect men and women of all ages, but it manifests most commonly in postmenopausal women. Patients with lichen sclerosus have an increased risk of developing squamous cell carcinoma, and they should be monitored for malignancy. Lichen planus is an inflammatory autoimmune disorder that can affect the vulva and the vagina; it peaks in incidence between ages 30 and 60. There are three clinical variants of lichen planus affecting the vulva: erosive, papulosquamous, and hypertrophic. Lichen simplex chronicus is caused by persistent itching and scratching of the vulvar skin, which results in a thickened, leathery appearance. It is thought to be an atopic disorder in many cases and may arise in normal skin as a result of psychological stress or environmental factors. Definitive diagnosis of non-neoplastic disorders depends on the histology of biopsied tissue. All three disorders are treated with topical corticosteroid ointments of varying potency. Lichen sclerosus and lichen planus are not routinely treated with surgery, which is necessary only in patients who have a malignancy or advanced scarring that causes dyspareunia or clitoral phimosis. Educational counseling teaches patients that even though these chronic disorders cannot be cured, they can be effectively managed.  (+info)

Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory skin condition that affects the genital skin, particularly the vulva in women. It is characterized by thin, white, crinkly skin that can be patchy or involve the entire vulvar area. The skin may become fragile and tear easily, leading to pain, itching (pruritus), discomfort, and soreness. In some cases, VLS can cause scarring and narrowing of the vaginal opening, which can make sexual intercourse painful.

The exact cause of Vulvar Lichen Sclerosus is not known, but it may be associated with hormonal imbalances, genetics, or an autoimmune response. While there is no cure for VLS, various treatments can help manage the symptoms and prevent complications. Topical corticosteroids are often used to reduce inflammation and relieve itching. Regular follow-ups with a healthcare provider are essential to monitor the condition and adjust treatment as necessary.

Lichen Sclerosus et Atrophicus (LSEA) is a chronic inflammatory skin condition that can affect both males and females, but it's most commonly found in women after menopause. It can occur at any age, including children. The condition typically affects the genital and anal areas, though it can appear elsewhere on the body as well.

The medical definition of Lichen Sclerosus et Atrophicus is:

A skin disorder characterized by white patches (plaques) that can be smooth or wrinkled, thickened, and easily bruised. These patches may merge to form larger areas of affected skin. The condition can cause itching, burning, pain, and blistering. In women, the vulva is often affected, and sexual intercourse may become painful. In men, it can affect the foreskin and glans penis, leading to difficulty urinating or having sex.

The exact cause of Lichen Sclerosus et Atrophicus remains unknown, but it's believed that hormonal imbalances, genetics, and an overactive immune system may play a role in its development. Treatment usually involves topical corticosteroids to reduce inflammation and alleviate symptoms. In some cases, other medications or phototherapy might be recommended. It is essential to consult with a healthcare professional for proper diagnosis and treatment.

Vulvodynia is a chronic pain condition that affects the vulva, which is the external female genital area. The main symptom is persistent, often burning or irritating pain without an identifiable cause. Some women may experience pain only when the area is touched (provoked vulvodynia), while others have constant pain (unprovoked vulvodynia).

The pain can significantly affect a woman's quality of life, making everyday activities like sitting, wearing tight clothes, or having sex uncomfortable or even unbearable. The exact cause of vulvodynia is not known, but it may be associated with nerve damage or irritation, hormonal changes, muscle spasms, allergies, or past genital infections. Treatment often involves a multidisciplinary approach and can include medication, physical therapy, lifestyle changes, and counseling.

Lichens are not a medical term, but I can provide a biological definition for you. Lichens are unique symbiotic organisms that result from the mutualistic relationship between fungi (usually Ascomycetes) and photosynthetic partners, such as algae or cyanobacteria. The fungal partner provides protection and anchorage, while the photosynthetic partner supplies carbohydrates through photosynthesis. Lichens are widely distributed and can be found growing on various substrates, including rocks, trees, and soil. They play essential ecological roles, such as soil stabilization, atmospheric nitrogen fixation, and biomonitoring of air pollution.

Vulvar diseases refer to a range of medical conditions that affect the vulva, which is the external female genital area including the mons pubis, labia majora and minora, clitoris, and the vaginal opening. These conditions can cause various symptoms such as itching, burning, pain, soreness, irritation, or abnormal growths or lesions. Some common vulvar diseases include:

1. Vulvitis: inflammation of the vulva that can be caused by infection, allergies, or irritants.
2. Lichen sclerosus: a chronic skin condition that causes thin, white patches on the vulva.
3. Lichen planus: an inflammatory condition that affects the skin and mucous membranes, including the vulva.
4. Vulvar cancer: a rare type of cancer that develops in the tissues of the vulva.
5. Genital warts: caused by human papillomavirus (HPV) infection, these are small growths or bumps on the vulva.
6. Pudendal neuralgia: a nerve condition that causes pain in the vulvar area.
7. Vestibulodynia: pain or discomfort in the vestibule, the area surrounding the vaginal opening.

It is important to consult a healthcare professional if experiencing any symptoms related to vulvar diseases for proper diagnosis and treatment.

Lichen Planus is a chronic, autoimmune skin condition that can also affect the mucous membranes inside the mouth, genitals, and eyes. It is characterized by the appearance of purplish, flat-topped bumps or lesions on the skin, which may be itchy. The exact cause of Lichen Planus is unknown, but it is believed to occur when the immune system mistakenly attacks cells in the skin or mucous membranes. Certain medications, viral infections, and genetic factors may increase the risk of developing this condition. Treatment typically focuses on managing symptoms and may include topical corticosteroids, oral medications, or light therapy.

Vulvar neoplasms refer to abnormal growths or tumors in the vulvar region, which is the exterior female genital area including the mons pubis, labia majora, labia minora, clitoris, and the vaginal vestibule. These neoplasms can be benign (non-cancerous) or malignant (cancerous).

Benign vulvar neoplasms may include conditions such as vulvar cysts, fibromas, lipomas, or condylomas (genital warts). They are typically slow-growing and less likely to spread or invade surrounding tissues.

Malignant vulvar neoplasms, on the other hand, are cancers that can invade nearby tissues and potentially metastasize (spread) to distant parts of the body. The most common types of malignant vulvar neoplasms are squamous cell carcinoma, vulvar melanoma, and adenocarcinoma.

Early detection and treatment of vulvar neoplasms are essential for improving prognosis and reducing the risk of complications or recurrence. Regular gynecological examinations, self-examinations, and prompt attention to any unusual symptoms or changes in the vulvar area can help ensure timely diagnosis and management.

Clobetasol is a topical corticosteroid medication that is used to reduce inflammation and relieve itching, redness, and swelling associated with various skin conditions. It works by suppressing the immune system's response to reduce inflammation. Clobetasol is available in several forms, including creams, ointments, emulsions, and foams, and is usually applied to the affected area once or twice a day.

It is important to use clobetasol only as directed by a healthcare provider, as prolonged or excessive use can lead to thinning of the skin, increased susceptibility to infections, and other side effects. Additionally, it should not be used on large areas of the body or for extended periods without medical supervision.

The vulva refers to the external female genital area. It includes the mons pubis (the pad of fatty tissue covered with skin and hair that's located on the front part of the pelvis), labia majora (the outer folds of skin that surround and protect the vaginal opening), labia minora (the inner folds of skin that surround the vaginal and urethral openings), clitoris (a small, sensitive organ located at the front of the vulva where the labia minora join), the external openings of the urethra (the tube that carries urine from the bladder out of the body) and vagina (the passageway leading to the cervix, which is the lower part of the uterus).

It's important to note that understanding the anatomy and terminology related to one's own body can help facilitate effective communication with healthcare providers, promote self-awareness, and support overall health and well-being.

Phimosis is a medical condition where the foreskin of the penis, which is the retractable sheath of skin that covers the head or glans of the penis, cannot be pulled back (retracted) over the glans. This condition is normal in uncircumcised infant boys and toddlers, but most boys can retract their foreskins by the time they reach puberty.

In some cases, phimosis may cause no symptoms or problems, while in others it may lead to issues such as discomfort, pain, especially during sexual activity, infection, inflammation, and difficulty urinating. Phimosis can be caused by various factors, including infections, skin conditions, scarring from previous injuries or surgeries, or forceful attempts to retract the foreskin.

Treatment for phimosis depends on the underlying cause and severity of the condition. In some cases, gentle manual stretching exercises may be recommended to gradually increase the foreskin's ability to retract. In other cases, topical creams or medications may be prescribed to reduce inflammation or fight infections. If these treatments are not effective, or if phimosis is causing significant discomfort or complications, circumcision (surgical removal of the foreskin) may be considered as a last resort.

Penile diseases refer to a range of medical conditions that affect the penis, including infections, inflammatory conditions, and structural abnormalities. Some common penile diseases include:

1. Balanitis: an infection or inflammation of the foreskin and/or head of the penis.
2. Balanoposthitis: an infection or inflammation of both the foreskin and the head of the penis.
3. Phimosis: a condition in which the foreskin is too tight to be pulled back over the head of the penis.
4. Paraphimosis: a medical emergency in which the foreskin becomes trapped behind the head of the penis and cannot be returned to its normal position.
5. Peyronie's disease: a condition characterized by the development of scar tissue inside the penis, leading to curvature during erections.
6. Erectile dysfunction: the inability to achieve or maintain an erection sufficient for sexual intercourse.
7. Penile cancer: a rare form of cancer that affects the skin and tissues of the penis.

These conditions can have various causes, including bacterial or fungal infections, sexually transmitted infections (STIs), skin conditions, trauma, or underlying medical conditions. Treatment for penile diseases varies depending on the specific condition and its severity, but may include medications, surgery, or lifestyle changes.

Localized scleroderma, also known as morphea, is a rare autoimmune disorder that affects the skin and connective tissues. It is characterized by thickening and hardening (sclerosis) of the skin in patches or bands, usually on the trunk, limbs, or face. Unlike systemic scleroderma, localized scleroderma does not affect internal organs, although it can cause significant disfigurement and disability in some cases.

There are two main types of localized scleroderma: plaque morphea and generalized morphea. Plaque morphea typically presents as oval or circular patches of thickened, hard skin that are often white or pale in the center and surrounded by a purple or darker border. Generalized morphea, on the other hand, is characterized by larger areas of sclerosis that can cover much of the body surface.

The exact cause of localized scleroderma is not fully understood, but it is thought to involve an overactive immune system response that leads to inflammation and scarring of the skin and underlying tissues. Treatment typically involves a combination of topical therapies (such as corticosteroids or calcineurin inhibitors), phototherapy, and systemic medications (such as methotrexate or mycophenolate mofetil) in more severe cases.

Lichen Planus, Oral is a relatively common inflammatory condition that affects the mucous membranes inside the mouth. It is characterized by the presence of white, lacy patches (called Wickham's striae), papules, or plaques on the oral mucosa, which can be uncomfortable or painful, especially when eating spicy, salty, or acidic foods. The condition can also cause soreness, redness, and ulceration in some cases.

The exact cause of oral lichen planus is not known, but it is believed to be related to an abnormal immune response in which the body's immune system attacks the cells in the oral mucosa. The condition can affect people of any age, but it is most commonly seen in middle-aged adults, and it affects women more often than men.

While there is no cure for oral lichen planus, treatment can help to manage symptoms and prevent complications. Topical corticosteroids are often used to reduce inflammation and relieve pain, while systemic medications may be prescribed in severe cases. It is important to avoid irritants such as tobacco, alcohol, and spicy foods, which can exacerbate symptoms. Regular dental check-ups are also recommended to monitor the condition and prevent any complications.

Women with lichen sclerosus may develop vulvar carcinoma. Lichen sclerosus is associated with 3-7% of all cases of vulvar ... Lichen sclerosus is associated with a higher risk of cancer. Skin that has been scarred as a result of lichen sclerosus is more ... Lichen sclerosus may have a genetic component. A high correlation of lichen sclerosus has been reported between twins and ... Lichen sclerosus et atrophicus was first described in 1887 by François Henri Hallopeau. Since not all cases of lichen sclerosus ...
Non-cancerous vulvar diseases include lichen sclerosus, squamous cell hyperplasia, and vulvar vestibulitis. A number of ... vulvar cancer Stage 1A and 1B vulvar cancer Stage 2 vulvar cancer Stage 3 vulvar cancer Stage 4A vulvar cancer Stage 4B vulvar ... Chronic inflammatory conditions of the vulva that may be precursors to vulvar cancer include lichen sclerosus, which can ... Vulvar lichen sclerosus Immunodeficiency syndromes Northern European ancestry Examination of the vulva is part of the ...
Vulvar vestibulitis usually affects pre-menopausal women. A number of skin disorders such as lichen sclerosus, and lichen ... The third most common subtype is vulvar melanoma. Studies have shown that vulvar melanomas appear to have a different tumor ... Vulvodynia is chronic pain in the vulvar region. There is no single identifiable cause. A subtype of this is vulvar ... which has a direct impact on the medical treatment of vulvar melanomas. Signs and symptoms of vulvar cancer can include: ...
These include, among others: vulvar dermatosis (lichen sclerosus, lichen planus), vulvar pain (vulvodynia), vulvar ... Terminology of Vulvar Squamous Intraepithelial Lesions". Journal of Lower Genital Tract Disease. 20 (1): 11-14. doi:10.1097/lgt ... "2006 ISSVD classification of vulvar dermatoses: pathologic subsets and their clinical correlates". The Journal of Reproductive ... "2011 ISSVD Terminology and Classification of Vulvar Dermatological Disorders". Journal of Lower Genital Tract Disease. 16 (4): ...
... is associated with vulvar dermatoses such as lichen sclerosus. It is associated with atypia of the squamous epithelium. The ... Smoking Immunosuppression Chronic vulvar irritation Conditions such as Lichen Sclerosus The person may have no symptoms, or ... lesions tend to be isolated and are located over a skin with a vulvar dermatosis such as Lichen slerosus. Micrograph of vulvar ... May 1989). "New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease". Hum. Pathol. 20 (5): ...
"Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell ... of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus". ...
"Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell ... epigenetic phenomenon has been observed in women affected by Vulvar Squamous cell carcinoma arose from vulver lichen sclerosus ...
July 2018). "Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar ...
"Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell ... mRNA levels of c-Jun tested higher in Vulvar cancer samples when compared with those of normal skin and preneoplastic vulvar ... C-jun has been observed overexpressed in Vulvar Squamous Cell Carcinoma samples, in association with hypermethylation-Induced ...
... including that caused by lichen sclerosus, and vaginismus. It is also considered an effective treatment for vulvar vestibulitis ... 2002) Perineoplasty for the treatment of introital stenosis related to vulvar lichen sclerosis. Am J Obs Gyn 186: 49-52. ... To perform loosening perineoplasty, a triangle of skin is excised from below the vulvar vestibule with its base near the ... Evaluation of the surgical treatment of vulvar vestibulitis. Eur J Obs Gyn Reprod Biol. 86: 135-138. American College of ...
... of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus". ... of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus". ... epigenetic phenomenon has been observed in women affected by Vulvar Squamous cell carcinoma arose from vulver lichen sclerosus ... Similarly, IRF6 has been found to be genetically and epigenetically disregulated in Vulvar cancer. Interferon regulatory ...
Treatment for vulvar lichen sclerosus may consist of topical hydrocortisone in mild cases, or stronger topical steroids (e.g. ... Lichen sclerosus is another common cause of vulvitis in children, and it often affects an hourglass or figure eight-shaped area ... lichen sclerosus, and infections with bacteria, fungi, and parasites. Dermatitis in infants is commonly caused by a soiled ... Vulvar Candida infections are uncommon in children, and generally occur in infants after antibiotic therapy, and in children ...
... of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus". ... mRNA levels of TP63 tested higher in Vulvar cancer samples when compared with those of normal skin and preneoplastic vulvar ... TP63 has been observed overexpressed in Vulvar Squamous Cell Carcinoma samples, in association with hypermethylation-Induced ...
... of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus". ...
Conditions that affect the surface of the vulva including LSEA (lichen sclerosus et atrophicus), or xerosis (dryness, ... When there are no visible findings on vulvar exam that would suggest a cause for superficial dyspareunia, a cotton-swab test ... Vulvodynia: Vulvodynia is a diagnosis of exclusion involving either generalized or localized vulvar pain most often described ... Localized provoked vulvodynia is the most recent terminology for what used to be called vulvar vestibulitis when the pain is ...
Lichen sclerosus is another common cause of vulvitis in children, and it often affects an hourglass or figure eight-shaped area ... Treatment for vulvar lichen sclerosis may consist of topical hydrocortisone in mild cases, or stronger topical steroids (e.g. ... Causes of vaginal bleeding in children include trauma, condyloma acuminata, lichen sclerosus, vulvovaginitis, tumors, urethral ... lichen sclerosus, and infections with bacteria, fungi, and parasites. Dermatitis in infants is commonly caused by a soiled ...
... vulvar lichen sclerosus MeSH C13.371.944.819 - vulvar neoplasms MeSH C13.371.944.902 - vulvitis MeSH C13.371.944.902.737 - ... vulvar neoplasms MeSH C13.371.820.800.820 - urologic neoplasms MeSH C13.371.820.800.820.125 - bladder neoplasms MeSH C13.371. ...
... lichen sclerosus Bowen's disease (penile or vulvar) erythroplasia of Queyrat bladder carcinoma in situ monoclonal gammopathy of ... in situ lobular carcinoma in situ Sclerosing adenosis Small duct papilloma oral submucous fibrosis erythroplakia lichen planus ...
... or vulvar lichen sclerosus (VLS) is a cutaneous condition characterized by atrophy and shrinkage of the skin ... Lichen sclerosus Balanitis xerotica obliterans List of cutaneous conditions Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, ...
... vulvar ulcers, vulvar skin conditions such as lichen sclerosus, and rarely, a tumor (benign or malignant vaginal tumors, or ... In premenopausal women, bleeding can be from the uterus, from vulvar or vaginal lesions, or from the cervix. A gynecologic ...
... of ovary folliculitis female genital prolapse follicular cyst of ovary labor Lichen simplex chronicus Lichen sclerosus Lichen ... "Disorders of the Vulva: Common Causes of Vulvar Pain, Burning, and Itching". American Congress of Obstatricians and ... "Disorders of the Vulva: Common Causes of Vulvar Pain, Burning, and Itching". American Congress of Obstetricians and ... vaginal dryness vaginismus vesico-uterine pouch vulvodynia vulva tumor vaginal bleeding vaginoplasty vulvar vestibulitis vulvar ...
... lichen planus Neoplasm: Paget's disease, vulvar carcinoma Neurologic disorder: neuralgia secondary to herpes virus, spinal ... an autoimmune disorder similar to lupus erythematosus or to eczema or to lichen sclerosus, infection (e.g., yeast infections, ... Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis or "localized (to the vestibule) provoked ... diagnosis is made by ruling out other causes of vulvar pain) could be confused with it. Vulvar pain is a quite frequent ...
Eczema/Dermatitis Lichen simplex (chronic eczema) Psoriasis Lichen sclerosus Lichen planus zoon's vulvitis (zoon's balanitis in ... Vulvar cancer accounts for about 5% of all gynecological cancers and typically affects women in later life. Five-year survival ... A vulvar disease is a particular abnormal, pathological condition that affects part or all of the vulva. Several pathologies ... may involve the perineal region Infantile perianal pyramidal protrusion Vulvar Lymphangioma Paget's disease of the vulva Vulvar ...
This surgery is also used to treat lichen sclerosus. "The complete surgery removes the entire lateral hymenal tissues to the ... Vestibulodynia (vulvar vestibulitis) is a chronic pain syndrome that is a subtype of localized vulvodynia where chronic pain ... In a study done in 2006, it was discovered that 93% of patients who had undergone the surgery recommended it for vulvar pain. ... Vulvar vestibulectomy is primarily supported as an intervention for people who suffer from provoked vestibulodynia, which ...
Lichen sclerosus-Lichen sclerosus is a disease causing white patches on the skin. Lichen sclerosus increases the risk of penile ... Male breast cancer Testicular cancer Urethral cancer Vulvar cancer "Penile Cancer Factsheet" (PDF). Global Cancer Observatory. ... As the exact cause of lichen sclerosus is unknown, there is no known way to prevent it. Tobacco-Chewing or smoking tobacco ... In HPV negative cancers the most common precursor lesion is lichen sclerosus (LS). The International Society of Urological ...
Lichen sclerosus overlap syndrome, sharing features of lichen planus and lichen sclerosus. Although lichen planus can present ... Oral lichen planus in children is rare. About 50% of females with oral lichen planus were reported to have undiagnosed vulvar ... "lichen planus actinicus", "Actinic lichen niditus", "Lichen planus atrophicus annularis", "Lichen planus subtropicus", "Lichen ... Oral lichen planus (also termed oral mucosal lichen planus), is a form of mucosal lichen planus, where lichen planus involves ...
Lichen planus pigmentosus Lichen planus-lichen sclerosus overlap syndrome Lichen ruber moniliformis Lichen sclerosus (lichen ... labial and penile and vulvar melanosis, melanotic macules) Nevus of Ito (nevus fuscoceruleus acromiodeltoideus) Nevus of Ota ( ... Annular lichen planus Atrophic lichen planus Bullous lichen planus (vesiculobullous lichen planus) Erosive lichen planus ... Kraurosis vulvae Lichen nitidus Lichen planus actinicus (actinic lichen niditus, actinic lichen planus, lichen planus ...
Lichen Sclerosus Support Network is a 501(c)(3) nonprofit organization (Tax ID #87-2172854). Contributions are received from ... Love the podcast! There is a support group on Facebook called lichen sclerosus a five star support group on Facebook! ... Welcome to episode six of season 2 of Lichen Sclerosus Podcast. Today we… ... Kathy is doing a great job of describing what it is like to have lichen sclerosis-which is not a common subject to hear spoken ...
... This can look like lumps, ulcers or ... What does cancerous lichen sclerosus look like?. Typical lesions of lichen sclerosus are porcelain-white papules and plaques, ... Lichen sclerosus can be a risk factor for skin cancer and vulvar cancer. This is why its important to see your doctor if you ... What happens if lichen sclerosus is left untreated?. Without treatment, the scratching associated with lichen simplex chronicus ...
Women with lichen sclerosus may develop vulvar carcinoma. Lichen sclerosus is associated with 3-7% of all cases of vulvar ... Lichen sclerosus is associated with a higher risk of cancer. Skin that has been scarred as a result of lichen sclerosus is more ... Lichen sclerosus may have a genetic component. A high correlation of lichen sclerosus has been reported between twins and ... Lichen sclerosus et atrophicus was first described in 1887 by François Henri Hallopeau. Since not all cases of lichen sclerosus ...
... BORGHI, ... OBJECTIVE: Dermoscopic features of vulvar lichen sclerosus (VLS) were investigated in order to determine both vascular and non- ... OBJECTIVE: Dermoscopic features of vulvar lichen sclerosus (VLS) were investigated in order to determine both vascular and non- ...
Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus ... Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus ... Lichen sclerosus (LS) has a known association with the development of squamous cell carcinoma of the vulva. The purpose of this ... Multiple sequential vulvar biopsies were taken over a period of 11 years from a patient with longstanding LS. ...
A Clinical and Histopathological Study of 25 Cases of Vulvar Lichen Sclerosus et Atrophicus [여성 외음부에 발생한 경화 위축성 태선에 대한 임상 및 ... Lichen sclerosus et atrophicus; Vulvar lichen sclerosus. Citation. Korean Journal of Dermatology, v.58, no.10, pp.643 - 649. ... Conclusion: Vulvar lichen sclerosus et atrophicus causes discomfort and diminishes the quality of life in older women. Early ... A Clinical and Histopathological Study of 25 Cases of Vulvar Lichen Sclerosus et Atrophicus [여성 외음부에 발생한 경화 위축성 태선에 대한 임상 및 ...
AFYX Therapeutics Presents Results from Rivelin Clinical Proof of Concept Study in Patients with Vulvar Lichen Sclerosus at the ... AFYX Therapeutics Presents Results from Rivelin Clinical Proof of Concept Study in Patients with Vulvar Lichen Sclerosus at the ... AFYX Therapeutics Presents Results from Rivelin Clinical Proof of Concept Study in Patients with Vulvar Lichen Sclerosus at the ...
Lichen sclerosus has both genital and extragenital presentations and also goes by the names lichen sclerosus et atrophicus ( ... Lichen sclerosus (LS) is a chronic inflammatory dermatosis that results in white plaques with epidermal atrophy and scarring. ... vulvar and penile lichen sclerosus), but it can occur at any skin site (extragenital lichen sclerosus). Outdated terms for this ... Of patients with vulvar lichen sclerosus, 8-39% report a family history of the condition, while only 1% of male genital lichen ...
Get detailed treatment information for newly diagnosed and recurrent vulvar cancer in this summary for clinicians. ... Vulvar cancer treatment options include a variety of surgical procedures, topical imiquimod, radiation therapy, chemotherapy, ... Nonneoplastic epithelial disorders of vulvar skin and mucosa. *Lichen sclerosus (lichen sclerosus et atrophicus). ... General Information About Vulvar Cancer. Revised text to state that vulvar cancer accounts for about 6% of cancers of the ...
Vulvar cancer is a rare type of gynecologic cancer that tends to grow slowly, usually over several years. Understand its ... Having precancerous cell changes like vulvar intraepithelial neoplasia (VIN). * Having a condition called lichen sclerosus. ... Vulvar cancer symptoms to watch for. You may not have any warning signs in the early stages of vulvar cancer. Some people with ... How to reduce your risk of vulvar cancer. Avoiding infection with HPV is one way to reduce your risk of vulvar cancer. This ...
A vulvar abscess is a buildup of bacteria and pus beneath the skin of the vulva. The vulva consists of the external genitals of ... Lichen sclerosus. Symptoms. Problems may be:. *Pain. *Itching. *Redness, warmth, and swelling ... Wash the vulvar area with soap and water. Dry it well.. *Clean and treat any minor skin wounds, such as those from hair removal ... A vulvar abscess is a buildup of bacteria and pus beneath the skin of the vulva. The vulva consists of the external genitals of ...
vulvar intraepithelial neoplasia. *lichen sclerosus of the vulva. *cervical cancer. *vaginal adenosis ... Vulvar and vaginal cancer are both rare. Vulvar cancer accounts for just 0.7%. of all cancers in people assigned female at ... vulvar. and vaginal. cancer is a history of other vulvar or vaginal conditions, including:. * ... More than half of all vaginal cancers - and up to 70% of all vulvar cancers - are caused by HPV. ...
Gender differences in genital lichen sclerosus: data from a multicenter Italian study on 729 consecutive cases - Giornale ... KEY WORDS: Vulvar lichen sclerosus; Sex characteristics; Therapeutics; Squamous cell carcinoma. inizio pagina ... Gender differences in genital lichen sclerosus: data from a multicenter Italian study on 729 consecutive cases. G Ital Dermatol ... Gender differences in genital lichen sclerosus: data from a multicenter Italian study on 729 consecutive cases. Annarosa ...
Clobetasol propionate 0.05% cream in the treatment of vulvar lichen sclerosus: effect on the immunohistological profile. * ... The treatment of vulval lichen sclerosus with a very potent topical steroid (clobetasol Propionate 0.05%) cream. *Article ... to 12 weeks of treatment with a very potent topical fluorinated steroid was studied in 15 patients with vulval lichen sclerosus ...
Most reported lichen sclerosus cases (83%) involve the genitalia. ... Childhood vulvar lichen sclerosus frequently resolves with the ... Lichen sclerosus is a chronic, progressive, sclerosing inflammatory dermatosis of unclear etiology. ... Hormonal influences in the development of lichen sclerosus have long been postulated, mainly in female vulvar lichen sclerosus. ... Whether the lichen sclerosus is directly attributable to HPV infection, or if lichen sclerosus merely promotes HPV infection is ...
3. Itching and pain in the vulvar area Your Dx:_____. Choose from the list below: ...
TOPIC CORTICOSTEROID AND PHOTOBIOMODULATION TREATMENT IMPACT ON VULVAR LICHEN SCLEROSUS: CLINICAL, INFLAMMATORY AND REPARATIVE ...
The Female Genital Self-image Scale in Adult Women With Vulvar Lichen Sclerosus. Journal of Lower Genital Tract Disease. 23 (3 ...
Learn about Lichen Sclerosus, including symptoms, causes, and treatments. If you or a loved one is affected by this condition, ... Vulvar lichen sclerosus requires aggressive treatment and life long monitoring to avert scarring and minimize risk of squamous ... Moreover, lesions of morphea may co-exist with lichen sclerosus on the body. For this reason, those with lichen sclerosus ... Lichen Sclerosus (Beyond the Basics). UpToDate. Review Date: Aug 24, 2018. https://www.uptodate.com/contents/lichen-sclerosus- ...
BACKGROUND: Vulvar lichen sclerosus (LS) affects primarily women at postmenopausal age and its background remains unknown. One ... Effectiveness of photodynamic therapy in the treatment of lichen sclerosus: cell changes in immunohistochemistry.. Olejek A, ... Effectiveness of photodynamic therapy in the treatment of lichen sclerosus: cell changes in immunohistochemistry. Neuro ... CONCLUSION: The immunohistochemical staining in vulvar LS showed increasing microvessel density and decreasing lymphocytic ...
Together with the OB/GYN department, she sees patients with Lichen Sclerosus, Lichen Planus, and vulvar/vaginal pain. Research ... interests include access to contraception as well as treatment of vulvar disorders. ...
You may or may not have heard of vulvar atrophy or lichen sclerosus, but odds are that you know someone who has been diagnosed ... Lichen sclerosus is not as common as vaginal atrophy and is most commonly experienced in postmenopausal women. Lichen sclerosus ... Vulvar Atrophy and Lichen Sclerosus - What You Need to Know. Jan 5. ... Note that lichen sclerosus is not limited to those areas and in some cases may affect the skin in the breast and upper arm ...
... vaginal lichen planus, vaginal lichen sclerosus, vaginal pemphigus); History of sexual abuse; Complications during birth; ... "Vulvar pain that is due to infection e.g. ureaplasma, candida or strep will respond to the appropriate treatment." ... Uterine Prolapse; Pelvic Mass Gynecological Cancer: Cervical, Ovarian, Uterine, Endometrial, Vulvar, or Vaginal; Uterine ...
Tammy brings her journey with Lichen Sclerosus and the experiences of many other women to light in t ... Women with Lichen Sclerosus are at a higher risk of getting vulvar intraepithelial neoplasia and other autoimmune conditions. ... What is Lichen Sclerosus? Lichen Sclerosus is an autoimmune condition where the body attacks itself. It is thought to be ... Lichen Sclerosus affects young and old women. Tammys history with Lichen Sclerosus Tammy started experiencing extreme itching ...
A 51-year-old patient presents for evaluation of possible vulvar lichen sclerosus. The patient describes a 12-month history of ... A biopsy done at the referring hospital demonstrated "stromal sclerosis, favor lichen sclerosus over amyloidosis." ... Vulvar amyloidosis. Dec 30, 2020. Natalie Saunders, MD. Kathryn Welch, MD*Ebony Parker-Featherstone, MD ... Vulvar amyloidosis is a rare, but important clinical entity. Its diagnosis can facilitate the recognition of a potentially life ...
Patients treated for vulvar carcinoma between 2018 and 2021 were recruited, and 84 (62.7%) responded. The mean age was 68 ± 12 ... To conclude, vulvar carcinoma and its treatment reduce self-reported health, mobility, and physical activity. This motivates us ... Patients treated for vulvar carcinoma may experience losses in mobility and physical activity. In this study, we assess the ... such as lichen sclerosus, were not excluded in our study. Vulvar cancer is characterized by life-long follow-up, gradual ...
Lichen sclerosus - Characteristic "figure-of-eight" distribution with fusion / regression of vulvar tissues. ... Vulvar atrophy - Usually more globally involved and can occur in vagina as well. ...
23 Hillemanns P, Untch M, Prove F, Baumgärtner R, Hillemanns M, Korell M. Photodynamic therapy of vulvar lichen sclerosus with ... 21 Fehr M K, Hornung R, Degen A, Schwarz V A, Fink D, Haller U, Wyss P. Photodynamic therapy of vulvar and vaginal condyloma ...
23:09 - Stephanie Chen, "Emotion Regulation and Sexual Communication in Couples Coping with Vulvar Lichen Sclerosus" ... 42:27 - Carly Johnston, "Developing and Testing Brief Patient Education Videos for Vulvar Lichen Sclerosus" ... "Associations Between Perceived Injustice and Sexual Health Outcomes in Couples Coping with Vulvar Lichen Sclerosus" ...
Patients with labial adhesion in the setting of vulvar lichen sclerosus were not included in this review. A single practitioner ... The presence of vulvar symptoms is typically addressed at each clinic visit and was recorded for 14 patients with symptomatic ... Additionally, vulvar symptoms prior to and following separation of the labial adhesion were available for 14 (of 16) patients. ... While, the treatments we utilize are similar to those previously reported (2, 3, 4), we emphasize the importance of vulvar ...
  • It has been noted that clinical diagnosis of BXO can be "almost unmistakable," though there are other dermatologic conditions such as lichen planus, localized scleroderma, leukoplakia, vitiligo, and the cutaneous rash of Lyme disease can have a similar appearance. (wikipedia.org)
  • It has been hypothesized that oral manifestations are underdiagnosed or misdiagnosed as oral lichen planus, or that environmental effects play a large role in disease expression. (medscape.com)
  • Increased circulating autoantibodies may be as high as 28%, comparable to the rate seen in bullous lichen planus. (medscape.com)
  • 11. Vulvar dermatoses: lichen sclerosus, lichen planus, and vulval dermatitis/lichen simplex chronicus. (nih.gov)
  • 20. [The rare case of erosive lichen planus with large leasions in vulvar area and vagina]. (nih.gov)
  • Risk of vulvar squamous cell carcinoma in lichen sclerosus and lichen planus: A systematic review. (msdmanuals.com)
  • Chronic vulvar inflammation - Certain skin conditions, such as lichen sclerosus, lichen planus and Paget's disease can cause long-term irritation of the vulvar skin, which can sometimes lead to cancer. (moffitt.org)
  • Any skin disorders can affect the skin outside the vagina, such as lichen sclerosus and lichen planus. (nccmed.com)
  • 13. Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva. (nih.gov)
  • Most women with vulvar intraepithelial neoplasia (VIN) have no symptoms at all. (cancer.org)
  • Precancerous conditions of the vulva or cervix - Because a small number of women with vulvar intraepithelial neoplasia will develop invasive vulvar cancer, a physician will usually recommend removing the abnormal cells and following up with regular check-ups. (moffitt.org)
  • For extragenital lichen sclerosus, phototherapy or methotrexate could be considered (treatment regimens analogous to those used for morphea). (medscape.com)
  • 6.5 mg/kg based on ideal body weight) as a systemic maintenance drug for both genital and extragenital lichen sclerosus. (medscape.com)
  • There are no RCTs evaluating the efficacy of treatment for extragenital lichen sclerosus, and recommendations are based on case reports and small uncontrolled studies. (medscape.com)
  • Lichen sclerosus (LS) is a chronic inflammatory dermatosis of unknown cause that most commonly affects the genitalia (vulvar and penile lichen sclerosus), but it can occur at any skin site (extragenital lichen sclerosus). (medscape.com)
  • 6. Clinicopathologic comparison of vulvar and extragenital lichen sclerosus: histologic variants, evolving lesions, and etiology of 141 cases. (nih.gov)
  • 3. Squamous cell carcinoma of the vulva in association with mixed vulvar dystrophy. (nih.gov)
  • 9. Malignant potential of mixed vulvar dystrophy (lichen sclerosus associated with squamous cell hyperplasia). (nih.gov)
  • The most common gynecologic problems observed in elderly women population are gynecologic cancers, vulvar dystrophy and genitourinary atrophy. (dergisi.org)
  • Pruritis vulva due to vulvar dystrophy is usually seen in elderly women. (dergisi.org)
  • The presence of a vulvar dystrophy, when adequately treated, does not significantly predispose the patient to the developent of vulvar carcinoma. (tau.ac.il)
  • Vulvectomy is contraindicated as a means of treatment in the vast majority of patients with a vulvar dystrophy. (tau.ac.il)
  • Histologic types are lichen sclerosus and squamous cell hyperplasia. (dergisi.org)
  • In most cases of vulvar cancer, lichen sclerosus, squamous cell hyperplasia or VIN have affected adjacent cells. (coyleinstitute.com)
  • Although several risk factors increase the odds of developing vulvar cancer, most women with these risks do not develop it. (cancer.org)
  • However, HPV exposure can sometimes lead to cellular changes that heighten a woman's risk of developing vulvar cancer. (moffitt.org)
  • The team of multispecialty experts at Moffitt Cancer Center's gynecological clinic can help women - especially those who have multiple risk factors - to better understand their risk of developing vulvar cancer, and also discuss options for risk reduction, early detection and treatment. (moffitt.org)
  • citation needed] According to the National Vulvodynia Association, which also supports women with lichen sclerosus, vulvo-vaginal conditions can cause feelings of isolation, hopelessness, low self-image, and much more. (wikipedia.org)
  • Dr. Krapf is active in research and has published chapters and peer-reviewed articles on vulvodynia and vulvar lichen sclerosus. (pelvicflooruniversity.com)
  • Outdated terms for this conditions include lichen sclerosus et atrophicus, balanitis xerotica obliterans (glans penis presentation), and kraurosis vulvae (older description of vulvar presentation). (medscape.com)
  • Local irritation or trauma seems to play a role in some cases of lichen sclerosus, especially in genetically predisposed individuals. (medscape.com)
  • More severe cases of lichen sclerosus produce scarring that may cause the inner lips of the vulva to shrink and disappear, the clitoris to become covered with scar tissue, and the opening of the vagina to narrow. (abchomeopathy.com)
  • A diagnosis of lichen sclerosis is no different - and does come with increased risks. (coyleinstitute.com)
  • The risk of lichen sclerosus becoming vulvar cancer is additionally increased when the initial diagnosis of lichen sclerosus is made in women over the age of 70. (coyleinstitute.com)
  • A biopsy specimen should always be obtained to confirm the diagnosis of lichen sclerosus. (melissadahir.com)
  • Identifying signs and symptoms of vulvar lichen sclerosus that may prompt a referral. (pelvicflooruniversity.com)
  • If a woman develops persistent symptoms of vulvar cancer, she should see her primary care physician or gynecologist for further evaluation. (santiagodiazpiedrahita.com)
  • 7. The role of vulvar skin biopsy in the evaluation of chronic vulvar pain. (nih.gov)
  • Because other diseases of the genitalia can look like lichen sclerosus, a biopsy is advised whenever the appearance of the skin is not typical of lichen sclerosus. (abchomeopathy.com)
  • Vulvar Biopsy - Leave A Scar? (bigresource.org)
  • How To Apply Anaesthetic Gel Before Vulvar Biopsy? (bigresource.org)
  • The vulvar biopsy specimens from 128 patients were grouped according to a predetermined classification. (tau.ac.il)
  • Vulvar lichen sclerosus (VLS) is a chronic, inflammatory skin condition of the vulva that most commonly affects postmenopausal women. (medscape.com)
  • Lichen sclerosis has been found in all age groups, but most affected individuals are postmenopausal. (estronaut.com)
  • While lichen sclerosus appears predominantly in postmenopausal women, this skin condition is also known to develop on the head of the penis in men. (abchomeopathy.com)
  • These and other recommendations presented in the EMAS clinical guide are published in the article: 'EMAS clinical guide: Vulvar lichen sclerosus in peri and postmenopausal women by Faustino R. P rez-L pez, Iuliana Ceausu, Herman Depypere, C. Tamer Erel, Irene Lambrinoudaki, Margaret Rees, Karin Schenck-Gustafsson, Florence Tremollieres, Yvonne T. van der Schouw and Tommaso Simoncini. (medindia.net)
  • Anyone at any age can get lichen sclerosus, but postmenopausal women are affected most often. (mayoclinic.org)
  • Some women with one or more risk factors will never develop the condition, while others with no apparent risk factors will be diagnosed with vulvar cancer. (moffitt.org)
  • Most women diagnosed with vulvar cancer are older than 50, and only a small percentage of vulvar cancer occurs in women ages 40 and under. (coyleinstitute.com)
  • Typical lesions of lichen sclerosus are porcelain-white papules and plaques, often seen in conjunction with areas of ecchymosis or purpura. (coyleinstitute.com)
  • Early detection and diagnosis of invasive lichen sclerosus lesions are crucial to reduce the risk of vulvar cancer. (coyleinstitute.com)
  • Zeiger, Roni F.. "Vulvar Lesions. (unboundmedicine.com)
  • Medicine Central , im.unboundmedicine.com/medicine/view/Diagnosaurus/114544/all/Vulvar_lesions. (unboundmedicine.com)
  • Lichen sclerosus (LS) is a chronic, inflammatory skin disease of unknown cause which can affect any body part of any person but has a strong preference for the genitals (penis, vulva) and is also known as balanitis xerotica obliterans (BXO) when it affects the penis. (wikipedia.org)
  • Lichen sclerosus of the penis occurs almost exclusively in uncircumcised men (those who have not had the foreskin removed). (abchomeopathy.com)
  • This image shows atrophy, hypopigmentation, and hyperpigmentation of the labia (top) and atrophy and hypopigmentation of the glans of the penis (bottom) resulting from lichen sclerosus. (msdmanuals.com)
  • 2. Prognostic significance of epithelial disorders adjacent to invasive vulvar carcinomas. (nih.gov)
  • 5. Non-neoplastic epithelial disorders of the vulva (vulvar dystrophies): historical and current perspectives. (nih.gov)
  • Women presenting with vulvar pruritus and pain should be examined by a health professional with expertise in vulvar skin disorders. (medindia.net)
  • Lichen Sclerosus (LS) is a chronic inflammatory skin disease that can affect any skin surface, but is most commonly seen in the genital and/or anal area. (melissadahir.com)
  • Lichen sclerosus comes with considerable risk for malignant transformation and anyone who is diagnosed will require ongoing monitoring. (coyleinstitute.com)
  • Genital warts, condyloma, vulvar itching, lichen sclerosus and atrophic lichen are some of these. (clinicaalejandria.es)
  • It should be recognized that vulvar lichen sclerosus patients typically do not develop atrophy with prolonged use, owing to the resistant nature of modified mucous membranes of the labia and clitoris (in contrast to perianal and hair-bearing skin of the labia majora, which can atrophy within 2-3 wk of use). (medscape.com)
  • The MAHEC Vulvar Clinic provides care to women throughout the region with vulvar skin conditions and genital pain. (mahec.net)
  • An area of VIN may look different than normal vulvar skin. (cancer.org)
  • Lichen sclerosus is a skin condition that can cause itching and pain, and while any body part can be affected, it typically involves the genitals, which can lead to vaginal and vulvar itching. (yahoo.com)
  • Potential role of the skin and gut microbiota in premenarchal vulvar lichen sclerosus: A pilot case-control study. (nih.gov)
  • Lichen sclerosus is a condition in which the skin around the vulva has a crinkled or parchment-like appearance. (estronaut.com)
  • Lichen sclerosus (LIKE-in skler-O-sus) is a chronic inflammatory skin disorder that can affect men, women, or children, but is most common in women. (abchomeopathy.com)
  • Skin on other areas of the body affected by lichen sclerosus usually does not develop scarring. (abchomeopathy.com)
  • It is uncommon for women who have vulvar lichen sclerosus to have the disease on other skin surfaces. (abchomeopathy.com)
  • Lichen sclerosus has also been shown to appear at sites of previous injury or trauma where the skin has already experienced scarring or damage. (abchomeopathy.com)
  • Vulvar lichen sclerosus (VLS) often goes untreated until advanced signs of skin damage occur. (contemporaryobgyn.net)
  • Vulvar lichen sclerosus causes light-colored, itchy patches of skin on the vulva. (mayoclinic.org)
  • Some research studies seem to show there may be a small chance that skin affected by lichen sclerosus could be at higher risk for developing cancer. (mayoclinic.org)
  • Atrophy and shriveling of the SKIN of the VULVA that is characterized by the whitish LICHEN SCLEROSUS appearance, inflammation, and PRURITUS . (nih.gov)
  • Vulvar lichen sclerosus is a chronic disorder of the skin. (coyleinstitute.com)
  • Changes in the surrounding skin cells that produce keratin, including chronic inflammation and sclerosus, may be responsible for the increased risk of vulvar cancer. (coyleinstitute.com)
  • Coyle Institute patients have reported 100 percent recovery from all lichen sclerosus symptoms following a session of the new TULIP® treatment including new, healed vulvar skin and tissues. (coyleinstitute.com)
  • Lichen Sclerosus is a chronic inflammatory skin condition that can affect the vulva. (medicinemama.com)
  • Scoop out a small amount with clean, dry fingers and massage into vulvar skin (includes inner and/or outer labia). (medicinemama.com)
  • Patients with lichen sclerosus have an increased risk for developing skin cancer known as squamous cell carcinoma. (melissadahir.com)
  • Also, failure to properly treat the vaginal tissues may increase the risk of developing vulvar skin cancer, or squamous cell carcinoma. (melissadahir.com)
  • And some women who don't have any apparent risk factors develop vulvar cancer. (cancer.org)
  • When a woman develops vulvar cancer, it is usually not possible to say with certainty that a particular risk factor was the cause. (cancer.org)
  • The risk of vulvar cancer goes up as women age. (cancer.org)
  • The average age of women diagnosed with invasive vulvar cancer is 70, whereas women diagnosed with non-invasive vulvar cancer average about 20 years younger. (cancer.org)
  • Lichen sclerosus is very, very important to diagnose because in addition to the fact that it can be really uncomfortable and miserable, there are long-term problems, if it's untreated, of increased risk of vulvar cancer down the road," says Streicher. (yahoo.com)
  • I have never been back for a recheck, but I recently read that I should be getting a regular exam, because this condition might cause vulvar cancer. (mayoclinic.org)
  • At this time, the evidence is not clear whether lichen sclerosus actually raises the risk for vulvar cancer , though there may be a small chance that cancer could develop. (mayoclinic.org)
  • At this time, the connection between vulvar lichen sclerosus and vulvar cancer is not clearly understood. (mayoclinic.org)
  • While the precise cause of vulvar cancer is unknown, certain risk factors are believed to influence a woman's chance of developing the condition. (moffitt.org)
  • therefore, it is possible for a woman to take preventive measures to help ensure that her vulvar cancer risk level is as low as possible. (moffitt.org)
  • Advanced age - While vulvar cancer can affect women of any age, the average age at diagnosis is 65. (moffitt.org)
  • Human immunodeficiency virus (HIV) - HIV weakens the body's immune system, which in turn can make a woman more susceptible to HPV and thus elevate her vulvar cancer risk. (moffitt.org)
  • Tobacco and alcohol use - Smoking and alcohol consumption increase the risk of many forms of cancer, including vulvar cancer. (moffitt.org)
  • To learn more about vulvar cancer risk factors, please call 1-888-663-3488 or register to schedule an appointment online . (moffitt.org)
  • It requires treatment because, if neglected, it can lead to the development of vulvar cancer. (medicalwholesome.com)
  • https://youtu.be/DC-u_GJrlIg Listen to the podcast here: Today we are joined (again) by therapeutic nutrition consultant, LS warrior, and vulvar cancer survivor, Heather Cooan. (lssupportnetwork.org)
  • Unfortunately, Heather went undiagnosed for over 25 years, allowing her Lichen Sclerosus to develop into cancer. (lssupportnetwork.org)
  • Doing so allowed Heather's Lichen Sclerosus to go into remission and she is now cancer-free! (lssupportnetwork.org)
  • Lichen Sclerosus and Vulvar Cancer: What are the Risks? (coyleinstitute.com)
  • Women must be especially vigilant about the various reproductive health issues that can contribute to cancer risks, including HPV and lichen sclerosus, which increases the risk of vulvar cancer. (coyleinstitute.com)
  • By mitigating risk factors as much as possible and treating and monitoring lichen sclerosus carefully, the risk of cancer can be lowered. (coyleinstitute.com)
  • Early detection of changes indicating vulvar cancer means women can seek effective treatment in early and even pre-cancerous stages. (coyleinstitute.com)
  • How does Vulvar Lichen Sclerosus Impact Vulvar Cancer Risk? (coyleinstitute.com)
  • Lichen sclerosus is found in adjacent regions in up to 62% of vulvar cancer patients. (coyleinstitute.com)
  • The increased risk of vulvar cancer is just one more reason why lichen sclerosus should be diagnosed early, treated as completely as possible and carefully monitored. (coyleinstitute.com)
  • Did you know that Lichen Sclerosus increases risk of vulvar cancer if left untreated? (pelvicflooruniversity.com)
  • Patients with vulvar cancer have a five-year survival rate of 86% for vulvar confined disease, while survival rates drop to 57% for patients with distant metastases. (santiagodiazpiedrahita.com)
  • What are the Differences Between Stages 1A and Stages 1B Vulvar Cancer? (santiagodiazpiedrahita.com)
  • reported on the evaluation of 27 patients with vulvar cancer, including seven patients with stage 1a and stage 1b disease and three patients with stage 0b and asymptomatic cecum. (santiagodiazpiedrahita.com)
  • Other than vulvar cancer, are there any other possible causes for these symptoms? (santiagodiazpiedrahita.com)
  • It is not easy to predict the survival rate of stage 1 vulvar cancer. (santiagodiazpiedrahita.com)
  • OBJECTIVES To assess the results of sentinel lymph node (SLN) detection in the initial stages of vulvar cancer and the recurrences that may appear. (santiagodiazpiedrahita.com)
  • The cancer of the vulvar typically grows slowly over several years. (santiagodiazpiedrahita.com)
  • Recent evidence suggests that vulvar cancer is becoming more common among younger women. (santiagodiazpiedrahita.com)
  • 80 vulvar cancer stock photos, vectors, and illustrations are available royalty-free. (santiagodiazpiedrahita.com)
  • Also, the survival rates for stage 1 vulvar cancer vary according to the stage and grade of the disease. (santiagodiazpiedrahita.com)
  • Most vulvar cancer is squamous in origin. (santiagodiazpiedrahita.com)
  • Staging tests can include: The stages of vulvar cancer are indicated by Roman numerals that range from I to IV, with the lowest stage indicating cancer that is limited to the vulva. (santiagodiazpiedrahita.com)
  • However, in extremely rare cases the sensation of burning may be attributed to vulvar cancer. (nccmed.com)
  • Vulvar cancers account for around 0.7 percent of all cancers of women in the United States, according to the American Cancer Society. (nccmed.com)
  • Fractional CO2 lasers, meanwhile, have been shown histologically to improve vaginal tissue and to alleviate self-reported vulvar symptoms of itching and dyspareunia. (contemporaryobgyn.net)
  • A condition which characteristically causes itching, pain, and dyspareunia, vulvar LS is most commonly diagnosed following menopause . (medscape.com)
  • This condition may also cause vulvar pain and severe itching of the vaginal area. (estronaut.com)
  • When first seen, the one patient who did develop carcinoma of the vulva had an initial vulvar carcinoma 3 years prior to the diagnosis of a second vulvar carcinoma and associated lichen sclerosus et atrophicus. (tau.ac.il)
  • It is estimated that up to 20% of all women will experience significant vulvar symptoms at some point in their lifetime. (medscape.com)
  • Women with lichen sclerosus have a higher rate of associated autoimmune disease (odds ratio, 4.3), especially for autoimmune thyroid disease, compared with men. (medscape.com)
  • Women are told they should use all these vulvar washes and other products, and it's really poison to the vulva," says Dr. Lauren Streicher , professor of obstetrics and gynecology at Northwestern University. (yahoo.com)
  • I ran a vulvar clinic, and one of the first things we would tell women when they came to the vulvar clinic is stop using all this junk on their vulva. (yahoo.com)
  • Given it is a chronic condition, most women who have vulvar lichen sclerosus need long-term treatment. (mayoclinic.org)
  • Two small randomized trials assessing the therapeutic value of fractionated carbon dioxide laser in women with vulvar LS were published in the June 2021 issue of the journal Obstetrics and Gynecology . (medscape.com)
  • Moreover, since insurance companies do not cover laser treatment for vulvar LS, this therapy is financially out of reach for many women. (medscape.com)
  • Topical avocado and soybean extracts as alternative treatments for mild-to-moderate lichen sclerosus have been used in patients wishing to avoid corticosteroids. (medscape.com)
  • When the charts on these 128 patients were reviewed, several facts relative to the vulvar dystrophies were noted. (tau.ac.il)
  • Genomic Profiling of Vulvar Lichen Sclerosus Patients Shows Possible Pathogenetic Disease Mechanisms. (bvsalud.org)
  • Do you feel confident in your ability to identify Lichen Sclerosus in your patients? (pelvicflooruniversity.com)
  • Utilizing physical therapy techniques to increase function in patients with vulvar lichen sclerosus. (pelvicflooruniversity.com)
  • There are many known causes of vaginal or vulvar itching, and they can range from the most mundane causes (like a new shower gel) to something much more serious. (yahoo.com)
  • One of the more common causes of vulvar and vaginal itching is a yeast infection, which can be caused by an overgrowth of fungus called candida. (yahoo.com)
  • When lichen sclerosus occurs on parts of the body other than the genital area, most often there are no symptoms, other than itching. (abchomeopathy.com)
  • Rarely, lichen sclerosus of the vulva may cause extreme itching that interferes with sleep and daily activities. (abchomeopathy.com)
  • Lichen sclerosus can cause anogenital bruising, itching, or blistering early, and atrophy and scarring later. (msdmanuals.com)
  • This vulvar itching may become worse at night. (melissadahir.com)
  • Very mild lichen sclerosus of the genital area often causes no symptoms at all. (abchomeopathy.com)
  • In cases of inner lip adhesion accompanied by lichen sclerosus disease, the entire genital area (large lips, perineum, and clitoral area) may be indistinct and flattened. (eserdag.com)
  • Why Laser Therapy for Lichen Sclerosus Isn't Worth the Cost - Medscape - Jun 11, 2021. (medscape.com)
  • Lichen sclerosus can occur in males or females of any age, but it more commonly affects prepubertal or perimenopausal females or males between puberty and age 60 years. (medscape.com)
  • Third-line therapies that could be considered in treatment-resistant genital lichen sclerosus could include topical or oral retinoids, steroid injections, cyclosporin (topical shown not to work), methotrexate, or hydroxyurea. (medscape.com)
  • Treatment of lichen sclerosus consists of potent topical corticosteroids (medications that otherwise should be used with extreme caution in this area). (msdmanuals.com)
  • Treatment of lichen sclerosus used to depend heavily on topical steroid creams. (coyleinstitute.com)
  • Topical therapy with the potent corticosteroid clobetasol represents the standard of care in treating vulvar LS. (medscape.com)
  • [ 17 ] Treatment is often extrapolated from data from studies in genital lichen sclerosus and studies in the treatment of morphea. (medscape.com)
  • In initial phases, lichen sclerosis has no major symptoms and does not require treatment. (estronaut.com)
  • The most common treatment for lichen sclerosus is a prescription of corticosteroid cream. (mayoclinic.org)
  • It is important to see your health care provider on a regular basis so he or she can confirm that the treatment for lichen sclerosus is working. (mayoclinic.org)
  • Why Laser Therapy for Lichen Sclerosus Isn't Worth the Cost Dr Andrew Kaunitz doesn't recommend this novel treatment in place of conventional topicals for vulvar lichen sclerosis. (medscape.com)
  • The symptoms related to the vulvar dystrophies can be adequately controlled with medical treatment. (tau.ac.il)
  • Recognizing treatment options for vulvar lichen sclerosus. (pelvicflooruniversity.com)
  • When lichen sclerosus develops around the anus, the discomfort can lead to constipation that is difficult to relieve. (abchomeopathy.com)
  • A clinical guide by the European Menopause and Andropause Society (EMAS) on lichen sclerosus with summary recommendations has been published in Maturitas. (medindia.net)
  • Vulvar lichen sclerosus (LS) is a chronic inflammatory disease which affects genital labial, perineal and perianal areas, producing significant discomfort and psychological distress. (medindia.net)
  • Lichen sclerosus is an inflammatory dermatosis of unknown cause, possibly autoimmune, that usually affects the anogenital area. (msdmanuals.com)
  • This photo shows atrophy and hypopigmentation in the vulvar and perianal areas. (msdmanuals.com)
  • 14. Audit of a multidisciplinary vulvar clinic in a gynecologic hospital. (nih.gov)
  • https://youtu.be/n_kMuoUogL0 Introduction Today I am joined by the amazing dermatologist, Dr. Sandy Flann, who is an expert on pediatric Lichen Sclerosus. (lssupportnetwork.org)
  • Yes, you heard that right, Pediatric Lichen Sclerosus! (lssupportnetwork.org)
  • 19. Focused ultrasound therapy of vulvar dystrophies: a feasibility study. (nih.gov)