Wikstroemia
Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica. (1/7)
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 microM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression. This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation. (+info)Lignans from the roots of Wikstroemia indica and their DPPH radical scavenging and nitric oxide inhibitory activities. (2/7)
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of two new lignan dimer bis-5,5-nortrachelogenin (1) and bis-5,5'-nortrachelogenin (2), and three known lignans. Compound 1 and lirioresinol B (5) inhibited NO production with IC50 values at 48.6 and 53.5 microM, respectively. Compound 5 also showed free radical scavenging effect on 1,1-diphenyl-2-picrylhydrazil (DPPH) at IC50 values at 19.5 microM. (+info)Two new diterpenoids from the buds of Wikstroemia chamaedaphne. (3/7)
(+info)Sikokianin D, a new C-3/C-3"-biflavanone from the roots of Wikstroemia indica. (4/7)
(+info)A daphnane diterpenoid isolated from Wikstroemia polyantha induces an inflammatory response and modulates miRNA activity. (5/7)
(+info)Four new dilignans from the roots of Wikstroemia indica. (6/7)
Phytochemical investigation of the roots of Wikstroemia indica led to the isolation of four new dilignans (1-4). Their structures were established on the basis of the spectroscopic data including UV, IR, high resolution-electron ionization-mass spectrometry (HR-ESI-MS), 1D- and 2D-NMR (1H-1H correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC) and rotating frame Overhauser enhancement spectroscopy (ROESY)). These dilignans were screened for their in vitro antiviral activities against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay. (+info)Oleodaphnoic acid and coriaceol, two new natural products from the stem bark of Wikstroemia coriacea. (7/7)
(+info)I'm sorry for any confusion, but "Wikstroemia" is not a medical term. It is a genus of flowering plants in the family Thymelaeaceae, commonly known as "buckbrush" or "winterberry." These shrubs are native to Asia and North America. They may have uses in traditional medicine in some cultures, but there is no widely accepted medical definition for "Wikstroemia." If you have any questions related to healthcare or health-related topics, I'd be happy to try to help answer them for you.
Sesquiterpenes are a class of terpenes, which are large and diverse group of naturally occurring organic compounds derived from isoprene, a five-carbon molecule. Sesquiterpenes are composed of three isoprene units, making them 15-carbon structures. They are synthesized in plants, fungi, and some insects, and can be found in various essential oils, resins, and other natural products.
Guaiane is a subclass of sesquiterpenes characterized by a particular carbon skeleton structure. Guaiane-type sesquiterpenes contain a unique bicyclic ring system with a five-membered ring fused to a seven-membered ring. This class of compounds includes various natural products, some of which have been found to exhibit biological activities, such as anti-inflammatory, antimicrobial, and cytotoxic effects.
Examples of guaiane sesquiterpenes include:
1. Guaiol: A compound found in the wood of the guaiacum tree, it has been used in traditional medicine for its anti-inflammatory properties.
2. Bulnesin: A compound isolated from the bulnesia sarmientoi tree, it has shown potential as an anticancer agent.
3. Elephantopusin: A compound found in elephantopus mollis, it has been studied for its anti-inflammatory and antioxidant properties.
It is important to note that while these compounds have demonstrated biological activities, further research is necessary to fully understand their mechanisms of action and potential therapeutic applications.