Amnesia
Amnesia, Retrograde
Amnesia, Anterograde
Amnesia, Transient Global
Korsakoff Syndrome
Memory
Alcohol Amnestic Disorder
Retention (Psychology)
Pyrithiamine
Diencephalon
Scopolamine Hydrobromide
Neuropsychological Tests
Confusion
Unconsciousness
Temporal Lobe
Autobiography as Topic
Hippocampus
Thalamic Diseases
Memory Disorders
Midazolam
Craniocerebral Trauma
Learning
Anisomycin
Paired-Associate Learning
Mamillary Bodies
Thiamine Deficiency
Preanesthetic Medication
Recognition (Psychology)
Anterior Thalamic Nuclei
Multiple Personality Disorder
Magnetic Resonance Imaging
Brain Damage, Chronic
Recovery from anterograde and retrograde amnesia after percutaneous drainage of a cystic craniopharyngioma. (1/84)
A case is reported of a cystic craniopharyngioma involving the floor and walls of the third ventricle. Pronounced anterograde and retrograde amnesia were documented preoperatively by formal testing. Rapid improvement in both new learning capacity and remote memory occurred after percutaneous twist drill drainage of the cystic portion of the tumour. The relevance of these observations to the amnesic syndrome and its neuropathological basis is discussed. (+info)Naloxone in the prevention of the adverse cognitive effects of ECT: a within-subject, placebo controlled study. (2/84)
Electroconvulsive therapy (ECT) is a highly effective treatment for major depression, but is also associated with characteristic cognitive side effects. Several reports document that endogenous opioids and their receptors are activated by electroconvulsive shock (ECS) and that naloxone in doses sufficient to block endogenous opioid receptors may reverse ECS-induced retrograde amnesia. This placebo-controlled, randomized, within-patient study was conducted to examine the potential of naloxone, given in doses sufficient to block opioid receptors (high dose), to ameliorate acute anterograde and retrograde memory impairments following ECT. Compared to placebo and low dose naloxone, high dose naloxone administered immediately before ECT resulted in significant reductions in anterograde amnesia, and better performance on an attention task. Both low and high dose naloxone improved verbal fluency. There were no beneficial effects of high dose naloxone on retrograde amnesia, and an indication that high dose naloxone may have worsened retrograde amnesia for shape stimuli. There were no effects of high dose naloxone on seizure duration, vital signs, and subjective side effects. The study is consistent with prior research in which change in behavioral and physiological measures was produced principally by naloxone doses sufficient to block endogenous opioid receptors and offers evidence of the potential for ameliorating some adverse cognitive effects associated with ECT. (+info)Anterograde and retrograde amnesia after lesions to frontal cortex in rats. (3/84)
A socially acquired food-preference test was used to assess effects of lesions to the frontal cortex on anterograde and retrograde memory in rats. In Experiment 1, there was no effect of lesion when rats were administered a two-choice test in which the target food was to be selected in the presence of a single distractor. In Experiment 2, a three-choice memory test was administered in which the target food was presented along with two equally palatable alternatives. In the latter test, lesioned groups displayed anterograde amnesia that increased with the length of the interval between postoperative acquisition and test, and a severe retrograde amnesia that extended equally over the entire range of intervals between preoperative acquisition and test. This outcome, which contrasted with the pattern of memory loss previously observed in rats with hippocampal lesions on this test, was interpreted as evidence for the strategic role of the frontal lobes in directing response selection and retrieval processes in memory. (+info)Reactivation-dependent changes in memory states in the terrestrial slug Limax flavus. (4/84)
The change in memory state in the terrestrial slug Limax flavus was studied using cooling-induced retrograde amnesia. Slugs were first conditioned to avoid carrot odor and then a second conditioning procedure was applied 1, 3, 6, or 7 days after the first conditioning trial. Cooling the slugs to approximately 1 degrees C on day 7 immediately after the presentation of the odor used in the conditioning resulted in retrograde amnesia in the slugs that were subject to a second conditioning on day 6 or 7, but not in slugs that were subject to a second conditioning on day 1 or 3. Next, second-order conditioning was used as the second conditioning procedure to distinguish the memory acquired in the first conditioning from that acquired in the second conditioning and similar results were obtained. These results suggest that the reactivation of memory altered the memory state from a cooling-insensitive state to a cooling-sensitive one. A possible model for memory states is discussed. (+info)Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice. (5/84)
In Pavlovian fear conditioning, a conditional stimulus (CS, usually a tone) is paired with an aversive unconditional stimulus (US, usually a foot shock) in a novel context. After even a single pairing, the animal comes to exhibit a long-lasting fear to the CS and the conditioning context, which can be measured as freezing, an adaptive defense reaction in mice. Both context and tone conditioning depend on the integrity of the amygdala, and context conditioning further depends on the hippocampus. The reliability and efficiency of the fear conditioning assay makes it an excellent candidate for the screening of learning and memory deficits in mutant mice. One obstacle is that freezing in mice has been accurately quantified only by human observers, using a tedious method that can be subject to bias. In the present study we generated a simple, high-speed, and highly accurate algorithm that scores freezing of four mice simultaneously using NIH Image on an ordinary Macintosh computer. The algorithm yielded a high correlation and excellent linear fit between computer and human scores across a broad range of conditions. This included the ability to score low pretraining baseline scores and accurately mimic the effects of two independent variables (shock intensity and test modality) on fear. Because we used a computer and digital video, we were able to acquire a secondary index of fear, activity suppression, as well as baseline activity scores. Moreover, we measured the unconditional response to shock. These additional measures can enhance the sensitivity of the assay to detect interesting memory phenotypes and control for possible confounds. Thus, this computer-assisted system for measuring behavior during fear conditioning allows for the standardized and carefully controlled assessment of multiple aspects of the fear conditioning experience. (+info)Profound amnesia after damage to the medial temporal lobe: A neuroanatomical and neuropsychological profile of patient E. P. (6/84)
E. P. became profoundly amnesic in 1992 after viral encephalitis, which damaged his medial temporal lobe bilaterally. Because of the rarity of such patients, we have performed a detailed neuroanatomical analysis of E. P.'s lesion using magnetic resonance imaging, and we have assessed his cognitive abilities with a wide range of neuropsychological tests. Finally, we have compared and contrasted the findings for E. P. with the noted amnesic patient H.M, whose surgical lesion is strikingly similar to E. P.'s lesion. (+info)Phosphorylated cAMP response element-binding protein as a molecular marker of memory processing in rat hippocampus: effect of novelty. (7/84)
From mollusks to mammals the activation of cAMP response element-binding protein (CREB) appears to be an important step in the formation of long-term memory (LTM). Here we show that a 5 min exposure to a novel environment (open field) 1 hr after acquisition of a one-trial inhibitory avoidance training hinders both the formation of LTM for the avoidance task and the increase in the phosphorylation state of hippocampal Ser 133 CREB [phosphorylated CREB (pCREB)] associated with the avoidance training. To determine whether this LTM deficit is attributable to the reduced pCREB level, rats were bilaterally cannulated to deliver Sp-adenosine 3', 5'-cyclic monophosphothioate (Sp-cAMPS), an activator of PKA. Infusion of Sp-Adenosine 3',5'-cyclic monophosphothioate Sp-cAMPS to CA1 region increased hippocampal pCREB levels and restored normal LTM of avoidance learning in rats exposed to novelty. Moreover, a 5 min exposure to the open field 10 min before the avoidance training interferes with the amnesic effect of a second 5 min exposure to the open field 1 hr after avoidance training and restores the hippocampal levels of pCREB. In contrast, the avoidance training-associated activation of extracellular signal-regulated kinases (p42 and p44 mitogen-activated protein kinases) in the hippocampus is not altered by novelty. Together, these findings suggest that novelty regulates LTM formation by modulating the phosphorylation state of CREB in the hippocampus. (+info)Retrograde amnesia for spatial memory induced by NMDA receptor-mediated long-term potentiation. (8/84)
If information is stored as distributed patterns of synaptic weights in the hippocampal formation, retention should be vulnerable to electrically induced long-term potentiation (LTP) of hippocampal synapses after learning. This prediction was tested by training animals in a spatial water maze task and then delivering bursts of high-frequency (HF) or control stimulation to the perforant path in the angular bundle. High-frequency stimulation induced LTP in the dentate gyrus and probably also at other hippocampal termination sites. Retention in a later probe test was disrupted. When the competitive NMDA receptor antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) was administered before the high-frequency stimulation, water maze retention was unimpaired. CPP administration blocked the induction of LTP. Thus, high-frequency stimulation of hippocampal afferents disrupts memory retention only when it induces a change in the spatial pattern of synaptic weights. The NMDA receptor dependency of this retrograde amnesia is consistent with the synaptic plasticity and memory hypothesis. (+info)Amnesia is a condition characterized by memory loss, which can be temporary or permanent. It may result from brain damage or disease, and it can affect various aspects of memory, such as the ability to recall past events (retrograde amnesia), the ability to form new memories (anterograde amnesia), or both. Amnesia can also affect a person's sense of identity and their ability to learn new skills.
There are several types of amnesia, including:
1. Anterograde amnesia: This type of amnesia affects the ability to form new memories after an injury or trauma. People with anterograde amnesia may have difficulty learning new information and remembering recent events.
2. Retrograde amnesia: Retrograde amnesia affects the ability to recall memories that were formed before an injury or trauma. People with retrograde amnesia may have trouble remembering events, people, or facts from their past.
3. Transient global amnesia: This is a temporary form of amnesia that usually lasts for less than 24 hours. It is often caused by a lack of blood flow to the brain, and it can be triggered by emotional stress, physical exertion, or other factors.
4. Korsakoff's syndrome: This is a type of amnesia that is caused by alcohol abuse and malnutrition. It is characterized by severe memory loss, confusion, and disorientation.
5. Dissociative amnesia: This type of amnesia is caused by psychological factors, such as trauma or stress. People with dissociative amnesia may have trouble remembering important personal information or events that are emotionally charged.
The treatment for amnesia depends on the underlying cause. In some cases, memory may improve over time, while in other cases, it may be permanent. Treatment may involve medication, therapy, or rehabilitation to help people with amnesia cope with their memory loss and develop new skills to compensate for their memory impairments.
Retrograde amnesia is a form of memory loss where an individual cannot recall information, events, or facts from their personal past before a specific point in time. This type of amnesia is caused by damage to the brain, often as a result of head injury, stroke, infection, or certain medical conditions. The extent and duration of retrograde amnesia can vary widely, depending on the severity and location of the brain injury. In some cases, memory function may return over time as the brain heals, while in other cases the memory loss may be permanent.
Anterograde amnesia is a specific type of memory loss where a person has difficulty forming new memories or learning and retaining new information after the onset of the amnesia. It is often caused by damage to certain parts of the brain, such as the hippocampus and surrounding structures, which play a crucial role in the formation of new memories.
In anterograde amnesia, people may have trouble remembering events that occurred after the onset of their memory impairment, while their ability to recall remote memories or those that were formed before the onset of the amnesia is typically preserved. The severity of anterograde amnesia can vary widely, from mild difficulty with learning new information to a complete inability to form any new memories.
Anterograde amnesia can be caused by various factors, including brain injury, infection, stroke, alcohol or drug abuse, seizures, and certain medical conditions such as Wernicke-Korsakoff syndrome, which is often associated with chronic alcoholism. Treatment for anterograde amnesia depends on the underlying cause and may involve medication, rehabilitation, or other interventions to help improve memory function.
Transient global amnesia (TGA) is a sudden, temporary episode of memory loss that cannot be explained by a more common neurological or medical condition. It is characterized by an inability to form new memories (anterograde amnesia) and to recall past events or personal information (retrograde amnesia). These memory gaps typically last for several hours, but may persist for up to 24 hours.
TGA usually affects people over the age of 50 and is more common in men than women. The exact cause of TGA is not known, although it has been associated with various triggers such as emotional stress, physical exertion, sudden immersion in cold water, sexual activity, and medical procedures.
During a TGA episode, individuals often repeat the same questions or statements due to their inability to form new memories. They may also appear confused or disoriented, but they typically remain conscious and maintain their ability to perform familiar tasks. Most people with TGA do not experience any long-term memory loss or other neurological symptoms after the episode resolves.
The diagnosis of TGA is based on the characteristic symptoms, a normal physical examination, and the exclusion of other potential causes of amnesia through medical testing. Treatment for TGA is generally supportive, focusing on reassuring the individual and providing a safe environment during the episode. Recurrent episodes of TGA are uncommon but can occur in some individuals.
Korsakoff syndrome is a neuropsychiatric disorder typically caused by alcohol abuse, specifically thiamine (vitamin B1) deficiency in the brain. It's often associated with Wernicke encephalopathy, and the two together are referred to as Wernicke-Korsakoff syndrome.
The main features of Korsakoff syndrome include severe memory impairment, particularly anterograde amnesia (inability to form new memories), confabulation (making up stories due to gaps in memory), and a lack of insight into their condition. Other cognitive functions like intelligence and perception are usually preserved.
The syndrome is believed to result from damage to the mammillary bodies and other structures in the diencephalon, particularly the thalamus. Treatment involves abstinence from alcohol, thiamine replacement, and a balanced diet. The prognosis varies but often includes some degree of permanent memory impairment.
In the context of medical and clinical neuroscience, memory is defined as the brain's ability to encode, store, retain, and recall information or experiences. Memory is a complex cognitive process that involves several interconnected regions of the brain and can be categorized into different types based on various factors such as duration and the nature of the information being remembered.
The major types of memory include:
1. Sensory memory: The shortest form of memory, responsible for holding incoming sensory information for a brief period (less than a second to several seconds) before it is either transferred to short-term memory or discarded.
2. Short-term memory (also called working memory): A temporary storage system that allows the brain to hold and manipulate information for approximately 20-30 seconds, although this duration can be extended through rehearsal strategies. Short-term memory has a limited capacity, typically thought to be around 7±2 items.
3. Long-term memory: The memory system responsible for storing large amounts of information over extended periods, ranging from minutes to a lifetime. Long-term memory has a much larger capacity compared to short-term memory and is divided into two main categories: explicit (declarative) memory and implicit (non-declarative) memory.
Explicit (declarative) memory can be further divided into episodic memory, which involves the recollection of specific events or episodes, including their temporal and spatial contexts, and semantic memory, which refers to the storage and retrieval of general knowledge, facts, concepts, and vocabulary, independent of personal experience or context.
Implicit (non-declarative) memory encompasses various forms of learning that do not require conscious awareness or intention, such as procedural memory (skills and habits), priming (facilitated processing of related stimuli), classical conditioning (associative learning), and habituation (reduced responsiveness to repeated stimuli).
Memory is a crucial aspect of human cognition and plays a significant role in various aspects of daily life, including learning, problem-solving, decision-making, social interactions, and personal identity. Memory dysfunction can result from various neurological and psychiatric conditions, such as dementia, Alzheimer's disease, stroke, traumatic brain injury, and depression.
Alcohol Amnestic Disorder is not listed as a separate disorder in the current edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is used by mental health professionals to diagnose mental conditions. However, it was previously included in earlier editions as a subtype of Amnestic Disorder due to the effects of substance use or exposure to toxins.
Alcohol Amnestic Disorder is characterized by significant memory impairment that is directly caused by alcohol consumption. This disorder can result in anterograde amnesia, which is the inability to form new memories after drinking, and/or retrograde amnesia, which involves forgetting previously learned information or personal experiences.
The diagnosis of Alcohol Amnestic Disorder typically requires a comprehensive medical and neuropsychological evaluation to determine the extent and nature of memory impairment, as well as to rule out other potential causes for cognitive decline. Treatment usually involves a combination of abstinence from alcohol, pharmacotherapy, and psychosocial interventions to address substance use disorder and any co-occurring mental health conditions.
"Mental recall," also known as "memory recall," refers to the ability to retrieve or bring information from your memory storage into your conscious mind, so you can think about, use, or apply it. This process involves accessing and retrieving stored memories in response to certain cues or prompts. It is a fundamental cognitive function that allows individuals to remember and recognize people, places, events, facts, and experiences.
In the context of medical terminology, mental recall may be used to assess an individual's cognitive abilities, particularly in relation to memory function. Impairments in memory recall can be indicative of various neurological or psychological conditions, such as dementia, Alzheimer's disease, or amnesia.
Avoidance learning is a type of conditioning in which an individual learns to act in a certain way to avoid experiencing an unpleasant or aversive stimulus. It is a form of learning that occurs when an organism changes its behavior to avoid a negative outcome or situation. This can be seen in both animals and humans, and it is often studied in the field of psychology and neuroscience.
In avoidance learning, the individual learns to associate a particular cue or stimulus with the unpleasant experience. Over time, they learn to perform an action to escape or avoid the cue, thereby preventing the negative outcome from occurring. For example, if a rat receives an electric shock every time it hears a certain tone, it may eventually learn to press a lever to turn off the tone and avoid the shock.
Avoidance learning can be adaptive in some situations, as it allows individuals to avoid dangerous or harmful stimuli. However, it can also become maladaptive if it leads to excessive fear or anxiety, or if it interferes with an individual's ability to function in daily life. For example, a person who has been attacked may develop a phobia of public places and avoid them altogether, even though this limits their ability to engage in social activities and live a normal life.
In summary, avoidance learning is a type of conditioning in which an individual learns to act in a certain way to avoid experiencing an unpleasant or aversive stimulus. It can be adaptive in some situations but can also become maladaptive if it leads to excessive fear or anxiety or interferes with daily functioning.
Pyrithiamine is not typically considered a medical term, but it is a chemical compound that has been used in scientific research. It's an antivitamin, specifically an analog of thiamine (vitamin B1), which means it can interfere with the metabolism of thiamine in the body.
Here's a more specific definition from a biochemical perspective:
Pyrithiamine is a synthetic organic compound with the formula C6H7N2O2S. It is an analog of thiamine, where the aminomethyl group of thiamine is replaced by a pyridine ring. This structural modification makes pyrithiamine unable to act as a vitamin, but it can still interact with the enzymes and transport proteins involved in thiamine metabolism. As a result, pyrithiamine has been used as a tool to study thiamine deficiency and its effects on various organisms, including mammals.
Please note that pyrithiamine is not a term commonly used in clinical medicine or patient care. If you have any concerns about vitamins, nutrition, or health-related topics, it's best to consult a healthcare professional for accurate information and advice tailored to your specific situation.
The diencephalon is a term used in anatomy to refer to the part of the brain that lies between the cerebrum and the midbrain. It includes several important structures, such as the thalamus, hypothalamus, epithalamus, and subthalamus.
The thalamus is a major relay station for sensory information, receiving input from all senses except smell and sending it to the appropriate areas of the cerebral cortex. The hypothalamus plays a crucial role in regulating various bodily functions, including hunger, thirst, body temperature, and sleep-wake cycles. It also produces hormones that regulate mood, growth, and development.
The epithalamus contains the pineal gland, which produces melatonin, a hormone that helps regulate sleep-wake cycles. The subthalamus is involved in motor control and coordination.
Overall, the diencephalon plays a critical role in integrating sensory information, regulating autonomic functions, and modulating behavior and emotion.
Scopolamine hydrobromide is a synthetic anticholinergic drug, which means it blocks the action of acetylcholine, a neurotransmitter in the nervous system. It is primarily used for its anti-motion sickness and anti-nausea effects. It can also be used to help with symptoms of Parkinson's disease, such as muscle stiffness and tremors.
In medical settings, scopolamine hydrobromide may be administered as a transdermal patch, which is placed behind the ear to allow for slow release into the body over several days. It can also be given as an injection or taken orally in the form of tablets or liquid solutions.
It's important to note that scopolamine hydrobromide can have various side effects, including dry mouth, blurred vision, dizziness, and drowsiness. It may also cause confusion, especially in older adults, and should be used with caution in patients with glaucoma, enlarged prostate, or certain heart conditions.
Neuropsychological tests are a type of psychological assessment that measures cognitive functions, such as attention, memory, language, problem-solving, and perception. These tests are used to help diagnose and understand the cognitive impact of neurological conditions, including dementia, traumatic brain injury, stroke, Parkinson's disease, and other disorders that affect the brain.
The tests are typically administered by a trained neuropsychologist and can take several hours to complete. They may involve paper-and-pencil tasks, computerized tasks, or interactive activities. The results of the tests are compared to normative data to help identify any areas of cognitive weakness or strength.
Neuropsychological testing can provide valuable information for treatment planning, rehabilitation, and assessing response to treatment. It can also be used in research to better understand the neural basis of cognition and the impact of neurological conditions on cognitive function.
Confusion is a state of bewilderment or disorientation in which a person has difficulty processing information, understanding their surroundings, and making clear decisions. It can be caused by various medical conditions such as infections, brain injury, stroke, dementia, alcohol or drug intoxication or withdrawal, and certain medications. Confusion can also occur in older adults due to age-related changes in the brain.
In medical terms, confusion is often referred to as "acute confusional state" or "delirium." It is characterized by symptoms such as difficulty paying attention, memory loss, disorientation, hallucinations, and delusions. Confusion can be a serious medical condition that requires immediate evaluation and treatment by a healthcare professional.
Unconsciousness is a state of complete awareness where a person is not responsive to stimuli and cannot be awakened. It is often caused by severe trauma, illness, or lack of oxygen supply to the brain. In medical terms, it is defined as a lack of response to verbal commands, pain, or other stimuli, indicating that the person's brain is not functioning at a level necessary to maintain wakefulness and awareness.
Unconsciousness can be described as having different levels, ranging from drowsiness to deep coma. The causes of unconsciousness can vary widely, including head injury, seizure, stroke, infection, drug overdose, or lack of oxygen supply to the brain. Depending on the cause and severity, unconsciousness may last for a few seconds or continue for an extended period, requiring medical intervention and treatment.
The temporal lobe is one of the four main lobes of the cerebral cortex in the brain, located on each side of the head roughly level with the ears. It plays a major role in auditory processing, memory, and emotion. The temporal lobe contains several key structures including the primary auditory cortex, which is responsible for analyzing sounds, and the hippocampus, which is crucial for forming new memories. Damage to the temporal lobe can result in various neurological symptoms such as hearing loss, memory impairment, and changes in emotional behavior.
An autobiography is a type of literature that describes the personal life experiences of an individual, written by that individual. It typically includes details about their upbringing, education, career, relationships, and other significant events in their life. The author may also reflect on their thoughts, feelings, and motivations during these experiences, providing insight into their personality and character.
Autobiographies can serve various purposes, such as sharing one's story with others, leaving a legacy for future generations, or exploring one's personal growth and development. They can be written in different styles, from straightforward and factual to introspective and reflective.
It is important to note that autobiographies are not always entirely accurate, as memory can be selective or distorted. Additionally, some individuals may choose to embellish or exaggerate certain aspects of their lives for dramatic effect or to protect the privacy of others. Nonetheless, autobiographies remain a valuable source of information about an individual's life and experiences.
The hippocampus is a complex, curved formation in the brain that resembles a seahorse (hence its name, from the Greek word "hippos" meaning horse and "kampos" meaning sea monster). It's part of the limbic system and plays crucial roles in the formation of memories, particularly long-term ones.
This region is involved in spatial navigation and cognitive maps, allowing us to recognize locations and remember how to get to them. Additionally, it's one of the first areas affected by Alzheimer's disease, which often results in memory loss as an early symptom.
Anatomically, it consists of two main parts: the Ammon's horn (or cornu ammonis) and the dentate gyrus. These structures are made up of distinct types of neurons that contribute to different aspects of learning and memory.
Thalamic diseases refer to conditions that affect the thalamus, which is a part of the brain that acts as a relay station for sensory and motor signals to the cerebral cortex. The thalamus plays a crucial role in regulating consciousness, sleep, and alertness. Thalamic diseases can cause a variety of symptoms depending on the specific area of the thalamus that is affected. These symptoms may include sensory disturbances, motor impairment, cognitive changes, and altered levels of consciousness. Examples of thalamic diseases include stroke, tumors, multiple sclerosis, infections, and degenerative disorders such as dementia and Parkinson's disease. Treatment for thalamic diseases depends on the underlying cause and may include medications, surgery, or rehabilitation therapy.
Memory disorders are a category of cognitive impairments that affect an individual's ability to acquire, store, retain, and retrieve memories. These disorders can be caused by various underlying medical conditions, including neurological disorders, psychiatric illnesses, substance abuse, or even normal aging processes. Some common memory disorders include:
1. Alzheimer's disease: A progressive neurodegenerative disorder that primarily affects older adults and is characterized by a decline in cognitive abilities, including memory, language, problem-solving, and decision-making skills.
2. Dementia: A broader term used to describe a group of symptoms associated with a decline in cognitive function severe enough to interfere with daily life. Alzheimer's disease is the most common cause of dementia, but other causes include vascular dementia, Lewy body dementia, and frontotemporal dementia.
3. Amnesia: A memory disorder characterized by difficulties in forming new memories or recalling previously learned information due to brain damage or disease. Amnesia can be temporary or permanent and may result from head trauma, stroke, infection, or substance abuse.
4. Mild cognitive impairment (MCI): A condition where an individual experiences mild but noticeable memory or cognitive difficulties that are greater than expected for their age and education level. While some individuals with MCI may progress to dementia, others may remain stable or even improve over time.
5. Korsakoff's syndrome: A memory disorder often caused by alcohol abuse and thiamine deficiency, characterized by severe short-term memory loss, confabulation (making up stories to fill in memory gaps), and disorientation.
It is essential to consult a healthcare professional if you or someone you know experiences persistent memory difficulties, as early diagnosis and intervention can help manage symptoms and improve quality of life.
Midazolam is a medication from the class of drugs known as benzodiazepines. It works by enhancing the effect of a neurotransmitter called gamma-aminobutyric acid (GABA), which has a calming effect on the brain and nervous system. Midazolam is often used for its sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties.
Medically, midazolam is used for various purposes, including:
1. Preoperative medication (sedation before surgery)
2. Procedural sedation (for minor surgical or diagnostic procedures)
3. Treatment of seizures (status epilepticus)
4. Sedation in critically ill patients
5. As an adjunct to anesthesia during surgeries
6. Treatment of alcohol withdrawal symptoms
7. To induce amnesia for certain medical or dental procedures
Midazolam is available in various forms, such as tablets, intravenous (IV) solutions, and intranasal sprays. It has a rapid onset of action and a short duration, making it suitable for brief, intermittent procedures. However, midazolam can cause side effects like drowsiness, confusion, respiratory depression, and memory impairment. Therefore, its use should be carefully monitored by healthcare professionals.
Craniocerebral trauma, also known as traumatic brain injury (TBI), is a type of injury that occurs to the head and brain. It can result from a variety of causes, including motor vehicle accidents, falls, sports injuries, violence, or other types of trauma. Craniocerebral trauma can range in severity from mild concussions to severe injuries that cause permanent disability or death.
The injury typically occurs when there is a sudden impact to the head, causing the brain to move within the skull and collide with the inside of the skull. This can result in bruising, bleeding, swelling, or tearing of brain tissue, as well as damage to blood vessels and nerves. In severe cases, the skull may be fractured or penetrated, leading to direct injury to the brain.
Symptoms of craniocerebral trauma can vary widely depending on the severity and location of the injury. They may include headache, dizziness, confusion, memory loss, difficulty speaking or understanding speech, changes in vision or hearing, weakness or numbness in the limbs, balance problems, and behavioral or emotional changes. In severe cases, the person may lose consciousness or fall into a coma.
Treatment for craniocerebral trauma depends on the severity of the injury. Mild injuries may be treated with rest, pain medication, and close monitoring, while more severe injuries may require surgery, intensive care, and rehabilitation. Prevention is key to reducing the incidence of craniocerebral trauma, including measures such as wearing seat belts and helmets, preventing falls, and avoiding violent situations.
In the context of medicine and healthcare, learning is often discussed in relation to learning abilities or disabilities that may impact an individual's capacity to acquire, process, retain, and apply new information or skills. Learning can be defined as the process of acquiring knowledge, understanding, behaviors, and skills through experience, instruction, or observation.
Learning disorders, also known as learning disabilities, are a type of neurodevelopmental disorder that affects an individual's ability to learn and process information in one or more areas, such as reading, writing, mathematics, or reasoning. These disorders are not related to intelligence or motivation but rather result from differences in the way the brain processes information.
It is important to note that learning can also be influenced by various factors, including age, cognitive abilities, physical and mental health status, cultural background, and educational experiences. Therefore, a comprehensive assessment of an individual's learning abilities and needs should take into account these various factors to provide appropriate support and interventions.
Anisomycin is an antibiotic derived from the bacterium Streptomyces griseolus. It is a potent inhibitor of protein synthesis and has been found to have antitumor, antiviral, and immunosuppressive properties. In medicine, it has been used experimentally in the treatment of some types of cancer, but its use is limited due to its significant side effects, including neurotoxicity.
In a medical or scientific context, 'anisomycin' refers specifically to this antibiotic compound and not to any general concept related to aniso- (meaning "unequal" or "asymmetrical") or -mycin (suffix indicating a bacterial antibiotic).
Paired-associate learning is a form of implicit or non-declarative memory task that involves learning and remembering the association between two unrelated items, such as a word and an object, or a taste and a sound. In this type of learning, the individual learns to respond appropriately when presented with one member of the pair, due to its association with the other member. This process is often used in various fields including cognitive psychology, neuroscience, and education to study memory, learning, and brain function.
The mamillary bodies are a pair of small, round structures located in the hypothalamus region of the brain. They play a crucial role in the limbic system, which is involved in emotions, memory, and learning. Specifically, the mamillary bodies are part of the circuit that forms the Papez circuit, a neural network responsible for memory and cognitive functions.
The mamillary bodies receive inputs from several brain regions, including the hippocampus, anterior thalamic nuclei, and cingulate gyrus. They then project this information to the thalamus, which in turn sends it to the cerebral cortex for further processing.
Damage to the mamillary bodies can result in memory impairment, as seen in patients with Korsakoff's syndrome, a condition often associated with chronic alcohol abuse.
Thiamine deficiency, also known as beriberi, is a condition that results from inadequate intake or impaired absorption of thiamine (vitamin B1), which is essential for energy metabolism and nerve function. This deficiency can lead to various symptoms such as peripheral neuropathy, muscle weakness, heart failure, and in severe cases, Wernicke-Korsakoff syndrome, a neurological disorder associated with alcoholism. Thiamine deficiency is commonly found in populations with poor nutrition, alcohol dependence, and gastrointestinal disorders affecting nutrient absorption.
Preanesthetic medication, also known as premedication, refers to the administration of medications before anesthesia to help prepare the patient for the upcoming procedure. These medications can serve various purposes, such as:
1. Anxiolysis: Reducing anxiety and promoting relaxation in patients before surgery.
2. Amnesia: Causing temporary memory loss to help patients forget the events leading up to the surgery.
3. Analgesia: Providing pain relief to minimize discomfort during and after the procedure.
4. Antisialagogue: Decreasing saliva production to reduce the risk of aspiration during intubation.
5. Bronchodilation: Relaxing bronchial smooth muscles, which can help improve respiratory function in patients with obstructive lung diseases.
6. Antiemetic: Preventing or reducing the likelihood of postoperative nausea and vomiting.
7. Sedation: Inducing a state of calmness and drowsiness to facilitate a smooth induction of anesthesia.
Common preanesthetic medications include benzodiazepines (e.g., midazolam), opioids (e.g., fentanyl), anticholinergics (e.g., glycopyrrolate), and H1-antihistamines (e.g., diphenhydramine). The choice of preanesthetic medication depends on the patient's medical history, comorbidities, and the type of anesthesia to be administered.
Verbal learning is a type of learning that involves the acquisition, processing, and retrieval of information presented in a verbal or written form. It is often assessed through tasks such as list learning, where an individual is asked to remember a list of words or sentences after a single presentation or multiple repetitions. Verbal learning is an important aspect of cognitive functioning and is commonly evaluated in neuropsychological assessments to help identify any memory or learning impairments.
The anterior thalamic nuclei are a group of nuclei in the thalamus, which is a part of the brain. The thalamus serves as a relay station for sensory and motor signals to the cerebral cortex. The anterior thalamic nuclei, specifically, are involved in various functions such as memory, navigation, and arousal. They receive inputs from the hippocampus and other limbic structures and project to the cingulate gyrus and other areas of the cerebral cortex. The anterior thalamic nuclei have been implicated in several neurological and psychiatric conditions, including epilepsy, Alzheimer's disease, and schizophrenia.
Multiple Personality Disorder (MPD) is currently referred to as Dissociative Identity Disorder (DID) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). It's a complex dissociative disorder involving the presence of two or more distinct identities or personality states that recurrently take control of an individual's behavior.
In DID, each identity, or 'alter', may have its own unique name, personal history, characteristics, and mannerisms. The switching between these identities is often triggered by stressful situations or traumatic memories.
This disorder typically develops as a coping mechanism in response to severe, prolonged trauma during early childhood, such as emotional, physical, or sexual abuse. It's important to note that this condition should be diagnosed and managed by mental health professionals with expertise in dissociative disorders.
Medical Definition:
Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.
Chronic brain damage is a condition characterized by long-term, persistent injury to the brain that results in cognitive, physical, and behavioral impairments. It can be caused by various factors such as trauma, hypoxia (lack of oxygen), infection, toxic exposure, or degenerative diseases. The effects of chronic brain damage may not be immediately apparent and can worsen over time, leading to significant disability and reduced quality of life.
The symptoms of chronic brain damage can vary widely depending on the severity and location of the injury. They may include:
* Cognitive impairments such as memory loss, difficulty concentrating, trouble with problem-solving and decision-making, and decreased learning ability
* Motor impairments such as weakness, tremors, poor coordination, and balance problems
* Sensory impairments such as hearing or vision loss, numbness, tingling, or altered sense of touch
* Speech and language difficulties such as aphasia (problems with understanding or producing speech) or dysarthria (slurred or slow speech)
* Behavioral changes such as irritability, mood swings, depression, anxiety, and personality changes
Chronic brain damage can be diagnosed through a combination of medical history, physical examination, neurological evaluation, and imaging studies such as MRI or CT scans. Treatment typically focuses on managing symptoms and maximizing function through rehabilitation therapies such as occupational therapy, speech therapy, and physical therapy. In some cases, medication or surgery may be necessary to address specific symptoms or underlying causes of the brain damage.
Retrograde amnesia
Ribot's law
Retrospective memory
Chain Chronicle
Amnesia
Motivated forgetting
Electroconvulsive therapy
Dissociative amnesia
Susan Kennedy
Van Breda murders
Engram (neuropsychology)
Susumu Tonegawa
Cicuta maculata
Epigenetic priming
Intraperitoneal injection
Memory consolidation
Amanita muscaria
Eyewitness memory (child testimony)
Sadma
Controversies about psychiatry
Temporoparietal junction
Sun Xiaoguo
Michael Kopelman
One True Love (2008 film)
Recall (memory)
Pasquale Calabrese
Blank (2019 film)
Wernicke-Korsakoff syndrome
Anterograde amnesia
Self-knowledge (psychology)
Retrograde amnesia - Wikipedia
Retrograde Amnesia: Comprehensive JRPG Retrospective
Retrograde Amnesia: Comprehensive JRPG Retrospective
Retrograde amnesia: Similarities between organic and psychogenic forms
American Sign Language ASL Video Dictionary - retrograde amnesia
retrograde amnesia<...
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"Retrograde Amnesia Induced by Electroconvulsive Shock and Carbon-Dioxi" by Eugene Hugo Galluscio
Clinical correlates of retrograde amnesia in mild traumatic brain injury<...
Multiple Traumatic Brain Injury with Temporary Loss of Brain Consciousness, and Retrograde Amnesia : Medical Exhibit
In the Event of the Unexpected Onset of Retrograde Amnesia | Cat Pierro | The Hypocrite Reader
Suikoden II E27: Married, Knighted, And Blighted [Battle Against Kiba] Retrograde Amnesia: Comprehensive JRPG Retrospective...
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I Was Drugged By A Stranger
Neuroscience's most famous brain is reconstructed | New Scientist
My Experience with Transient Global Amnesia (TGA) | Psychology Today
The Wrong Marlowe | Los Angeles Review of Books
Staff | Max Planck Institute for Human Cognitive and Brain Sciences
Publications | Max Planck Institute for Human Cognitive and Brain Sciences
Frontiers | Reactivation, Retrieval, Replay and Reconsolidation in and Out of Sleep: Connecting the Dots
Professor Rick Richardson
Amnesia Beam Under Dev - Uh, What Was I Saying: Science Fiction in the News
A One-Horse Town? | Maine Boats Homes & Harbors
Korsakoff's syndrome
Knife in the Head: German Social Realism Meets Cinema Verité - Senses of Cinema
Alcoholism Clinical Presentation: History, Physical, Causes
Anterograde and retrograde amnesia4
- There are many well-known cases of individuals who have experienced these types of amnesia, with one of the most famous being that of Clive Wearing , a gifted British musician who developed both profound anterograde and retrograde amnesia, resulting in a desperate existence. (psychologytoday.com)
- Individuals diagnosed with Korsakoff's syndrome usually have symptoms of severe anterograde and retrograde amnesia, as well as confabulation. (englishgratis.com)
- This would be a mixture of anterograde and retrograde amnesia, as the patient would have lost memories from both before and after the event. (blogspot.com)
- Transient global amnesia is characterized by sudden-onset anterograde and retrograde amnesia that typically lasts up to 24 hours. (msdmanuals.com)
Post-traumat4
- Traumatic brain injury (TBI), also known as post-traumatic amnesia, occurs from an external force that causes structural damage to the brain, such as a sharp blow to the head, a diffuse axonal injury, or childhood brain damage (e.g., shaken baby syndrome). (wikipedia.org)
- Main outcomes and results: GCS scores and duration of post-traumatic amnesia (PTA) were related to RA. (tuni.fi)
- The most common is the post-traumatic amnesia, wherein the person can't remember the events immediately after the traumatic incident occurs. (jeffhurtblog.com)
- Post-traumatic amnesia lasts for less than an hour in 6% of the cases, while 7% of those surveyed experienced memory loss for an hour to a day. (jeffhurtblog.com)
Inability6
- In neurology, retrograde amnesia (RA) is the inability to access memories or information from before an injury or disease occurred. (wikipedia.org)
- RA differs from a similar condition called anterograde amnesia (AA), which is the inability to form new memories following injury or disease onset. (wikipedia.org)
- In a fugue state, people not only suffer from retrograde amnesia (an inability to recall the past), but they also have erased all biographical information from their memory. (psychologytoday.com)
- Anterograde amnesia is the inability to form new memories, and it may result from damage to the hippocampus that has occurred through accident or disease. (psychologytoday.com)
- anterograde amnesia - inability to consolidate information about ongoing events. (brainline.org)
- Lastly, retrograde amnesia is the inability to remember events before a traumatic head injury. (jeffhurtblog.com)
Temporally graded2
- More extensive damage limited to the hippocampus causes temporally graded amnesia for 15 to 25 years. (wikipedia.org)
- He showed that temporally graded retrograde amnesia could be obtained for a well-established memory in rats, if that memory were activated by a reminder of the original learning experience. (frontiersin.org)
Memories11
- Until recently it was emphasized that anterograde and retrograde memories are strongly linked so that a loss of the ability to form new memories is accompanied by an impairment in the retrieval of old memories. (uni-bielefeld.de)
- Some drugs will create retrograde amnesia for memories formed minutes before administration, but not much longer than that. (stackexchange.com)
- They don't wipe out memories formed before the drug was taken and therefore can't be said to cause retrograde amnesia. (stackexchange.com)
- His resulting amnesia and willingness to be tested have given us unprecedented insights into where memories are formed and stored in the brain. (newscientist.com)
- As a result, Molaison's epilepsy became manageable, but he could not form any new memories, a condition known as anterograde amnesia . (newscientist.com)
- Cue-dependent amnesia could likewise be induced by protein synthesis inhibition in much the same way that newly acquired memories are. (frontiersin.org)
- A patient with retrograde amnesia has lost memories or information from before the insulting event. (blogspot.com)
- A patient with anterograde amnesia has trouble forming new memories or storing new information, and therefore loses information from after the insulting event. (blogspot.com)
- Patients with Alzheimer's disease often suffer from anterograde amnesia symptoms, becoming less and less able to make new memories, and then moving into retrograde amnesia and losing past memories as well. (blogspot.com)
- Retrograde amnesia affects memories around the time of the incident, while anteriograde amnesia affects recent memories, Seattle Weekly explains. (findlaw.com)
- Although affected persons may be as attentive and awake as ever, their access to previously acquired memories may be disturbed (retrograde amnesia). (scientificamerican.com)
Kinds of amnesia2
- For many years, I have taught courses in which the topic of "amnesia" comes up in at least a superficial way, and there are many different kinds of amnesia. (psychologytoday.com)
- Basically, there are two kinds of amnesia. (blogspot.com)
Traumatic2
- Primary objective: The purpose of this study was to examine the clinical significance of retrograde amnesia (RA) in patients with acute mild traumatic brain injuries (MTBI). (tuni.fi)
- Someone with a significant traumatic brain injury, might have anterograde amnesia symptoms on a permanent basis. (blogspot.com)
Severe5
- Generally, this is a more severe type of amnesia known as global, or generalized amnesia. (wikipedia.org)
- Sometimes, retrograde amnesia occurs following a blow to the head that results in the loss of events that occurred just prior to the injury, but the memory loss can be much more extensive and debilitating if there has been severe brain damage. (psychologytoday.com)
- This type of amnesia may be caused by severe emotional stress, but in such cases, people almost always retain knowledge of who they are and of those with whom they are close. (scientificamerican.com)
- But a less severe retrograde amnesia may be the presenting symptom. (msdmanuals.com)
- These tests can help rule out other possible causes of the amnesia (eg, severe anemia, clotting disorders). (msdmanuals.com)
Disorders1
- Amnesias are amnestic disorders. (alleydog.com)
Concussion1
- D.D.B.'s trampoline injury caused "skull fracture, head lacerations, a concussion, and retrograde and anteriograde amnesia," the lawsuit states. (findlaw.com)
Dissociative1
- The type that perhaps comes to mind most quickly is the amnesia that accompanies a dissociative fugue state . (psychologytoday.com)
Clinical2
- Clinical microbiology of amnesia. (cdc.gov)
- retrograde amnesia was the only clinical relevant remaining symptom by 6 months. (bvsalud.org)
Psychogenic2
- H.J. Markowitsch, "Retrograde amnesia: Similarities between organic and psychogenic forms", NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH , vol. 4, 1996, pp. 1-8. (uni-bielefeld.de)
- Markowitsch, H.J.: Retrograde amnesia: Similarities between organic and psychogenic forms. (uni-bielefeld.de)
Onset4
- Retrograde amnesia is a form of amnesia where someone is unable to recall events that occurred before the development of the amnesia, even though they may be able to encode and memorize new things that occur after the onset. (stackexchange.com)
- This file contains the proximate will and testament of Jaime Amanda Fuller, to be delivered to her in the event of an onset of retrograde amnesia. (hypocritereader.com)
- Anterograde amnesia sufferers can remember events from their past but cannot retain new knowledge or information after the onset of the amnestic disorder. (alleydog.com)
- Acute-onset amnesia: Transient global amnesia and other causes. (msdmanuals.com)
Occur3
- Results from a few recent case reports show that selective retrograde amnesia may occur. (uni-bielefeld.de)
- This argument, however, is less than cogent because we know today that partial amnesia can occur and that it can affect certain memory systems such as episodic memory (of events) while leaving semantic (factual) memory intact. (scientificamerican.com)
- In addition, short-term memory lapses such as transient global amnesia lasting no more than 24 hours are known to occur. (scientificamerican.com)
Transient2
- The annual incidence of transient global amnesia is between 3.4 and 10.4/100 000. (msdmanuals.com)
- The etiology of transient global amnesia is not clear. (msdmanuals.com)
Selective1
- Given all the attention lately to Amnesia Drugs , Selective Memory Deletion by altering enzymes and Memory-Erasing Chemicals , it's good to know that amnesia beams are not being neglected. (technovelgy.com)
Rats2
- A day after training, when memory expression was robust and reliable in control rats, the tone was presented alone, followed by ECS, a treatment that produces amnesia when administered after learning. (frontiersin.org)
- It turns out that it is possible to induce retrograde amnesia in rats with a brilliant flash of light. (technovelgy.com)
Partial1
- He also had difficulty recollecting his long-term past - partial retrograde amnesia. (newscientist.com)
Produces1
- It has been demonstrated that electron beam exposure produces retrograde amnesia (RA). (technovelgy.com)
Occurs1
- Retrograde amnesia occurs when one cannot recall events from one's own past. (psychologytoday.com)
Podcast1
- Welcome to Retrograde Amnesia, a podcast where we cover classic Japanese Role-playing Games (JRPGs), chapter by chapter, beat by beat. (libsyn.com)
Typically2
- In reality, retrograde amnesia is typically limited to a relatively brief period immediately before whatever insult caused the loss of memory (which could be a brain injury-- either through head trauma, or oxygen deprivation, a seizure, drug and/or alcohol exposure, and any experience that could cause loss of consciousness). (blogspot.com)
- The amnesia typically remits spontaneously but may recur. (msdmanuals.com)
Events2
- amnesia - lack of memory about events occurring during a particular period of time. (brainline.org)
- Retrograde amnesia is a condition in which the sufferer cannot remember events before the amnestic disorder began. (alleydog.com)
Past1
- With that definition in mind, I don't think drugs exist that cause retrograde amnesia for the past few days, much less years. (stackexchange.com)
Suggests1
- Regarding your question of a pure retrograde amnesia, this suggests the common plot device in movies and television stories where the victim suffers a head injury and suddenly forgets everything about their own pasts, including their identities. (blogspot.com)
Diagnosis1
- For diagnosis of amnesia, the physician would primarily rely on the patient's history, as obtained by talking to the patient and his or her family and friends (if available), as well as simple tasks to evaluate the patient's ability to remember new things (such as giving the patient a string of numbers or a random trio of words to remember). (blogspot.com)
Alcohol1
- Long term alcohol abuse can cause retrograde amnesia, but that's due to the brain damage it causes after long-term abuse. (stackexchange.com)
Chemicals1
- Which chemicals or drugs cause retrograde amnesia? (stackexchange.com)
Laboratory1
- Further experiments from the Lewis laboratory showed that the phenomenon of cue-dependent amnesia was not limited to aversive Pavlovian conditioning protocols. (frontiersin.org)
Drugs1
- You'll find many sources listing drugs that cause retrograde amnesia but they're using the term incorrectly. (stackexchange.com)
Pure2
- An absence of anterograde amnesia (AA) characterizes pure forms of RA, which fall into three main categories: focal, isolated, and pure RA. (wikipedia.org)
- The case of pure retrograde amnesia. (bvsalud.org)
Mechanisms1
- The present review emphasizes that common mechanisms may underlie these two forms of retrograde amnesia. (uni-bielefeld.de)
Consequences2
- Retrograde amnesia can be one of the many consequences of brain injury but it is important to note that it is not always the outcome of TBI. (wikipedia.org)
- You're 64 years old, suffering from amnesia, glaucoma, and the consequences of a stroke. (lareviewofbooks.org)
Time3
- Retrograde amnesia makes it difficult for a person to recall experiences before a specific point in time. (psychcentral.com)
- If the photoflash had produced retrograde amnesia (RA), the time required to enter would be small. (technovelgy.com)
- Retrograde is RETRO , meaning backwards in time. (blogspot.com)
Case2
- A case study on focal retrograde amnesia. (mpg.de)
- In her novel The Lost Days of Agatha Christie, American therapist Carole Owens doubts this was a case of amnesia because the author clearly remembered the name of her husband's lover, at least to the extent that she used it in Harrogate. (scientificamerican.com)
Common1
- Amnesia resulting from physical problems with the brain are more common. (psychologytoday.com)
Search1
- Re-discovery of cue-dependent amnesia, wide availability of functional imaging tools and increased dialog among clinicians, cognitive psychologists, behavioral neuroscientists, and neurobiologists have provided impetus for the search for new paradigms for the study of memory. (frontiersin.org)
Type1
- How would a doctor diagnose retrograde amnesia and how would a patient act or think with this type of amnesia? (blogspot.com)
Patients1
- Even patients with devastating retrograde amnesia generally maintain their sense of identity. (blogspot.com)