A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Intravenous injections of sodium amytal or sodium pentothal to induce a state in which the patient is more relaxed and communicative. Narcosuggestion, narcosynthesis, and narcoanalysis are therapeutic processes using these drug adjuncts.
A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (active or passive refusal to follow commands), mannerisms, stereotypies, posturing, grimacing, excitement, echolalia, echopraxia, muscular rigidity, and stupor; sometimes punctuated by sudden violent outbursts, panic, or hallucinations. This condition may be associated with psychiatric illnesses (e.g., SCHIZOPHRENIA; MOOD DISORDERS) or organic disorders (NEUROLEPTIC MALIGNANT SYNDROME; ENCEPHALITIS, etc.). (From DSM-IV, 4th ed, 1994; APA, Thesaurus of Psychological Index Terms, 1994)
A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.
A sedative and mild hypnotic with potentially toxic effects.
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Delivery of drugs into an artery.
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)

Regional cerebral perfusion and amytal distribution during the Wada test. (1/167)

The distribution of sodium amytal and its effect on regional cerebral perfusion during the intracarotid amytal (Wada) test were investigated using high-resolution hexamethyl propyleneamine oxime (HMPAO) SPECT coregistered with the patient's MRI dataset. METHODS: Twenty patients underwent SPECT after intravenous HMPAO injection, and 5 patients had both intravenous and intracarotid injections in a double injection-acquisition protocol. RESULTS: All patients had hypoperfusion in the territories of the anterior and middle cerebral arteries. Basal ganglia perfusion was preserved in 20 of 25 patients. Hypoperfusion of the entire mesial temporal cortex was seen in 9 of 25 patients. Partial hypoperfusion of the whole mesial cortex or hypoperfusion of part of the mesial cortex was seen in 14 of 25 patients. In 2 of 25 patients, mesial temporal perfusion was unaffected. In 5 patients, the double acquisition showed a distribution of HMPAO delivery matching that of hypoperfusion, except for the following: (a) HMPAO was delivered to the basal ganglia and insula, where there was no hypoperfusion; (b) HMPAO was not delivered to the contralateral cerebellum, which did show hypoperfusion; and (c) in 1 patient, perfusion of the mesial temporal cortex was preserved despite intracarotid delivery of HMPAO. CONCLUSION: Some degree of hypoperfusion of medial temporal structures occurs in the great majority of patients during the Wada test. Partial inactivation of memory structures is therefore a credible mechanism of action of the test. The double acquisition protocol provided no evidence that mesial temporal structures are inactivated remotely by diaschisis. Perfusion in the basal ganglia and insular cortex is not affected by amytal.  (+info)

Drug blockade of open end-plate channels. (2/167)

1. The actions of amylobarbitone, thiopentone, methohexitone and methyprylone at voltage-clamped frog end-plates were studied. 2. In the presence of barbiturates the conductance change evoked by an iontophoretic carbachol application was reduced by a prepulse of carbachol. The extra inhibition evoked by a prepulse disappeared exponentially with a time constant of 150-200 ms. 3. Barbiturates produce an increased rate of decay of nerve evoked endplate currents. Tne concentration and voltage dependence of the barbtiruate e.p.c. decay rates tally with the hypothesis that the increased rate of decay is due to block of active receptor-channel complexes by barbiturates with a rate constant of 10(6) M-1S-1. 4. Conductance changes produced by bath applied agonists were depressed by thiopentone, the effect becoming greater the higher the agonist concentration. This effect, and also the observation that the concentration of thiopentone required to depress the bath agonist response is much greater than the apparent dissociation constant for binding to active receptor-channel complexes calculated from kinetic measurements, suggest that the selectivity for binding to open receptor-channel complexes is very high. 5. Methyprylone, which is structurally similar to the barbiturates, is only a weak antagonist and shows no interpulse interaction. It was predicted that methyprylone should produce fast and slow components in the e.p.c. decay, and this prediction was verified. 6. In the presence of barbiturates large iontophoretic carbachol applications produce conductance changes which show fast and slow components. Under these conditions the effects of carbachol prepulses become complex. However the effects are qualitatively consistent with the notion that different components of the response are contributed by channels located at various distances from the iontophoretic pipette tip. 7. All the data agree with a model in which the channel has three stages: closed, open and blocked. Only open channels can block, and blocked channels can only open.  (+info)

Functional MRI and the Wada test provide complementary information for predicting post-operative seizure control. (3/167)

Prediction of post-surgical seizure relief and potential cognitive deficits secondary to anterior temporal lobectomy (ATL) are important to pre-surgical planning. Although the intracarotid amobarbital test (IAT) is predictive of post-ATL seizure outcome, development of non-invasive and more precise means for determining post-ATL seizure relief are needed. We previously reported on a technique utilizing functional MRI (fMRI) to evaluate the relative functional adequacy of mesial temporal lobe structures in preparation for ATL. In the present study, we report follow-up outcome data on eight temporal lobe epilepsy (TLE) patients 1-year post-ATL who were evaluated pre-surgically using IAT and fMRI. Functional memory lateralization using fMRI predicted post-ATL seizure outcome as effectively as the IAT. In general, asymmetry of functional mTL activation favouring the non-epileptic hemisphere was associated with seizure-free status at 1-year follow-up. Moreover, when combined, fMRI and IAT provided complementary data that resulted in improved prediction of post-operative seizure control compared with either procedure alone.  (+info)

Comparison of localizing values of various diagnostic tests in non-lesional medial temporal lobe epilepsy. (4/167)

Though the surgical treatment for medial temporal lobe epilepsy yields a high success rate, more studies are needed in order to determine the most efficacious pre-operative algorithm. The authors studied the relationship between surgical outcome and the localization results of various pre-operative diagnostic tests to assess the predictive value. Seventy-one consecutive patients who had undergone anterior temporal lobectomy with amygdalohippocampectomy with the diagnosis of non-lesional medial temporal lobe epilepsy, who had been followed up more than 24 months, were analyzed retrospectively. Electroencephalogy (EEG), magnetic resonance imaging (MRI), proton emission tomography (PET), single photon emission computed tomography (SPECT), the Wada test, and neuropsychological testing were analyzed. There was no diagnostic test that was found to have a statistically significant relationship between Engel Class I outcome and localization results (P & 0.05). SPECT, neuropsychological testing, and the Wada test all had less predictive values (P < 0.01). EEG and PET had comparable predictive values for Engel Class I with MRI (P & 0.05). No single diagnostic test alone is sufficient to make a diagnosis of non-lesional medial temporal lobe epilepsy. MRI, EEG and PET had comparable predictive values for Engel Class I. SPECT, neuropsychological testing, and the Wada test had less predictive values.  (+info)

Lateralized memory deficits on the Wada test correlate with the side of lobectomy only for patients with unilateral medial temporal lobe epilepsy. (5/167)

The aim of this study was to determine whether the predictive value of the intracarotid amobarbital test (IAT) for the side to be resected is applicable only to medial temporal lobe epilepsy and to investigate whether there are different patterns of memory performances on the IAT between patients with unilateral mesial temporal sclerosis (UMT group) and those without (non-UMT group). We studied 30 patients in the UMT group and 10 in the non-UMT group, who underwent pre-surgical evaluation for intractable temporal lobe epilepsy. Memory performances on the IAT was defined as the percentage of memory items presented during unilateral hemispheric anesthesia that was recognized after recovery. More than a 20% decline of the memory performance on the IAT compared with the memory performance on the pre-test was regarded as a memory deficit. Age at onset of epilepsy was significantly younger in the UMT than in the non-UMT group. Surgical outcome was significantly better in the UMT than in the non-UMT group. The lateralizing value of unilateral memory deficits on the IAT was statistically confirmed. There was a significant association between falsely lateralizing memory performances and the non-UMT group. Excluding the exceptional cases with right-sided language dominance in spite of right-sided lesions, the high incidence of the unilateral right-sided memory deficits in the non-UMT group was statistically significant. This study suggested that the excellent lateralizing value of the memory performances on the IAT is limited to patients with mesial temporal lobe epilepsy. IAT memory performances in patients without such lesions can be misleading, even if lateralized, because their memory status presumably reflects a natural lateralization of the memory organization which is independent of the epileptogenic focus.  (+info)

Absent vestibulo-ocular reflexes and acute supratentorial lesions. (6/167)

Loss of vestibulo-ocular reflexes occurred in two patients with acute supratentorial lesions who received therapeutic doses of anticonvulsant drugs. There was no clinical or angiographic evidence of focal brain-stem damage. Absence of vestibulo-ocular reflexes is attributed to a combination of acute cerebral damage and anticonvulsant drugs. The loss of these reflexes in patients with acute cerebral lesions cannot be interpreted as evidence of irreversible brain-stem injury.  (+info)

Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis. (7/167)

It is generally accepted that mild forms of diabetes render the heart resistant to an ischemic insult. Because myocytes incubated chronically in medium containing high concentrations of glucose (25 mM) develop into a diabetes-like phenotype, we tested the hypothesis that high-glucose treatment diminishes hypoxia-induced injury. In support of this hypothesis, we found that cardiomyocytes incubated for 3 days with medium containing 25 mM glucose showed less hypoxia-induced apoptosis and necrosis than cells exposed to medium containing 5 mM glucose (control). Indeed, whereas 27% of control cells became necrotic after 1 h of chemical hypoxia with 10 mM deoxyglucose and 5 mM amobarbital (Amytal), only 11% of the glucose-treated cells became necrotic. Similarly, glucose treatment reduced the extent of apoptosis from 32% to 12%. This beneficial effect of glucose treatment was associated with a 40% reduction in the Ca(2+) content of the hypoxic cell. Glucose treatment also mediated an upregulation of the cardioprotective factor Bcl-2 but did not affect the cellular content of the proapoptotic factors Bax and Bad. Nonetheless, the phosphorylation state of Bad was shifted in favor of its inactive, phosphorylated form after high-glucose treatment. These data suggest that glucose treatment renders the cardiomyocyte resistant to hypoxia-induced apoptosis and necrosis by preventing the accumulation of Ca(2+) during hypoxia, promoting the upregulation of Bcl-2, and enhancing the inactivation of Bad.  (+info)

Transcortical sensory aphasia: revisited and revised. (8/167)

Transcortical sensory aphasia (TSA) is characterized by impaired auditory comprehension with intact repetition and fluent speech. We induced TSA transiently by electrical interference during routine cortical function mapping in six adult seizure patients. For each patient, TSA was associated with multiple posterior cortical sites, including the posterior superior and middle temporal gyri, in classical Wernicke's area. A number of TSA sites were immediately adjacent to sites where Wernicke's aphasia was elicited in the same patients. Phonological decoding of speech sounds was assessed by auditory syllable discrimination and found to be intact at all sites where TSA was induced. At a subset of electrode sites where the pattern of language deficits otherwise resembled TSA, naming and word reading remained intact. Language lateralization testing by intracarotid amobarbital injection showed no evidence of independent right hemisphere language. These results suggest that TSA may result from a one-way disruption between left hemisphere phonology and lexical-semantic processing.  (+info)

Amobarbital is a barbiturate drug that is primarily used as a sedative and sleep aid. It works by depressing the central nervous system, which can lead to relaxation, drowsiness, and reduced anxiety. Amobarbital is also sometimes used as an anticonvulsant to help control seizures.

Like other barbiturates, amobarbital has a high potential for abuse and addiction, and it can be dangerous or even fatal when taken in large doses or mixed with alcohol or other drugs. It is typically prescribed only for short-term use due to the risk of tolerance and dependence.

It's important to note that the use of barbiturates like amobarbital has declined in recent years due to the development of safer and more effective alternatives, such as benzodiazepines and non-benzodiazepine sleep aids.

Narcotherapy is not a recognized term in modern medicine. However, it appears that you might be looking for "narcoanalysis" or "narcotherapy," which are related concepts used in the past but have fallen out of favor due to ethical concerns and the development of more effective treatments. Here's the definition of narcoanalysis:

Narcoanalysis (or sometimes referred to as narcotherapy) is a psychiatric procedure that involves the use of barbiturates or short-acting general anesthetics, such as sodium pentothal or thiopental, to induce a hypnotic state in which patients may reveal unconscious thoughts, feelings, and memories that are not accessible in their normal conscious state. The goal is to help uncover repressed emotions or experiences that contribute to psychological distress or maladaptive behaviors.

It's important to note that this procedure has been associated with significant controversy due to concerns about the reliability of information obtained during the hypnotic state and potential manipulation by the interviewer. Additionally, there are ethical issues related to informed consent and the possibility of causing harm to patients through memory recall or revival of traumatic experiences. As a result, narcoanalysis is not commonly used in contemporary psychiatric practice.

Catatonia is a state of neurogenic motor immobility and behavioral abnormality manifested by stupor, mutism, negativism, rigidity, posturing, stereotypy, agitation, or Grimmacing. It can be a symptom associated with various neurological and mental disorders, such as schizophrenia, bipolar disorder, depression, or brain injury. Catatonic symptoms can also occur as a side effect of certain medications.

The diagnosis of catatonia is typically made based on the observation of characteristic clinical symptoms and the exclusion of other potential causes through medical evaluation. Treatment for catatonia may include medication, such as benzodiazepines or electroconvulsive therapy (ECT), depending on the underlying cause and severity of the symptoms.

Barbiturates are a class of drugs that act as central nervous system depressants, which means they slow down the activity of the brain and nerves. They were commonly used in the past to treat conditions such as anxiety, insomnia, and seizures, but their use has declined due to the risk of addiction, abuse, and serious side effects. Barbiturates can also be used for surgical anesthesia and as a treatment for barbiturate or pentobarbital overdose.

Barbiturates work by enhancing the activity of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which results in sedation, hypnosis, and anticonvulsant effects. However, at higher doses, barbiturates can cause respiratory depression, coma, and even death.

Some examples of barbiturates include pentobarbital, phenobarbital, secobarbital, and amobarbital. These drugs are usually available in the form of tablets, capsules, or injectable solutions. It is important to note that barbiturates should only be used under the supervision of a healthcare professional, as they carry a high risk of dependence and abuse.

I apologize, but I am not able to provide a medical definition for "Bromisovalum" because it is not a recognized or validated medication or substance in the field of medicine. It is possible that there may be a spelling error or typo in the term you provided. If you have more information about what you are looking for, I will do my best to help you find the correct information.

Methohexital is a rapidly acting barbiturate sedative-hypnotic agent primarily used for the induction of anesthesia. It is a short-acting drug, with an onset of action of approximately one minute and a duration of action of about 5 to 10 minutes. Methohexital is highly lipid soluble, which allows it to rapidly cross the blood-brain barrier and produce a rapid and profound sedative effect.

Methohexital is administered intravenously and works by depressing the central nervous system (CNS), producing a range of effects from mild sedation to general anesthesia. At lower doses, it can cause drowsiness, confusion, and amnesia, while at higher doses, it can lead to unconsciousness and suppression of respiratory function.

Methohexital is also used for diagnostic procedures that require sedation, such as electroconvulsive therapy (ECT) and cerebral angiography. It is not commonly used outside of hospital or clinical settings due to its potential for serious adverse effects, including respiratory depression, cardiovascular instability, and anaphylaxis.

It's important to note that Methohexital should only be administered by trained medical professionals under close supervision, as it requires careful titration to achieve the desired level of sedation while minimizing the risk of adverse effects.

Secobarbital is a barbiturate medication that is primarily used for the treatment of short-term insomnia and as a preoperative sedative. It works by depressing the central nervous system, producing a calming effect and helping to induce sleep. Secobarbital has a rapid onset of action and a relatively short duration of effect.

It is available in various forms, including capsules and injectable solutions, and is typically prescribed for use on an as-needed basis rather than as a regular medication. Secobarbital can be habit-forming and carries a risk of dependence and withdrawal, so it should only be used under the close supervision of a healthcare provider.

It's important to note that Secobarbital is not commonly prescribed in modern medical practice due to its high potential for abuse and the availability of safer and more effective sleep aids.

Hypnotics and sedatives are classes of medications that have depressant effects on the central nervous system, leading to sedation (calming or inducing sleep), reduction in anxiety, and in some cases, decreased awareness or memory. These agents work by affecting the neurotransmitter GABA (gamma-aminobutyric acid) in the brain, which results in inhibitory effects on neuronal activity.

Hypnotics are primarily used for the treatment of insomnia and other sleep disorders, while sedatives are often prescribed to manage anxiety or to produce a calming effect before medical procedures. Some medications can function as both hypnotics and sedatives, depending on the dosage and specific formulation. Common examples of these medications include benzodiazepines (such as diazepam and lorazepam), non-benzodiazepine hypnotics (such as zolpidem and eszopiclone), barbiturates, and certain antihistamines.

It is essential to use these medications under the guidance of a healthcare professional, as they can have potential side effects, such as drowsiness, dizziness, confusion, and impaired coordination. Additionally, long-term use or high doses may lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.

GABA (gamma-aminobutyric acid) modulators are substances that affect the function of GABA, which is the primary inhibitory neurotransmitter in the central nervous system. GABA plays a crucial role in regulating neuronal excitability and reducing the activity of overactive nerve cells.

GABA modulators can either enhance or decrease the activity of GABA receptors, depending on their specific mechanism of action. These substances can be classified into two main categories:

1. Positive allosteric modulators (PAMs): These compounds bind to a site on the GABA receptor that is distinct from the neurotransmitter binding site and enhance the activity of GABA at the receptor, leading to increased inhibitory signaling in the brain. Examples of positive allosteric modulators include benzodiazepines, barbiturates, and certain non-benzodiazepine drugs used for anxiolysis, sedation, and muscle relaxation.
2. Negative allosteric modulators (NAMs): These compounds bind to a site on the GABA receptor that reduces the activity of GABA at the receptor, leading to decreased inhibitory signaling in the brain. Examples of negative allosteric modulators include certain antiepileptic drugs and alcohol, which can reduce the effectiveness of GABA-mediated inhibition and contribute to their proconvulsant effects.

It is important to note that while GABA modulators can have therapeutic benefits in treating various neurological and psychiatric conditions, they can also carry risks for abuse, dependence, and adverse side effects, particularly when used at high doses or over extended periods.

Intra-arterial injection is a type of medical procedure where a medication or contrast agent is delivered directly into an artery. This technique is used for various therapeutic and diagnostic purposes.

For instance, intra-arterial chemotherapy may be used to deliver cancer drugs directly to the site of a tumor, while intra-arterial thrombolysis involves the administration of clot-busting medications to treat arterial blockages caused by blood clots. Intra-arterial injections are also used in diagnostic imaging procedures such as angiography, where a contrast agent is injected into an artery to visualize the blood vessels and identify any abnormalities.

It's important to note that intra-arterial injections require precise placement of the needle or catheter into the artery, and are typically performed by trained medical professionals using specialized equipment.

Temporal lobe epilepsy (TLE) is a type of focal (localized) epilepsy that originates from the temporal lobes of the brain. The temporal lobes are located on each side of the brain and are involved in processing sensory information, memory, and emotion. TLE is characterized by recurrent seizures that originate from one or both temporal lobes.

The symptoms of TLE can vary depending on the specific area of the temporal lobe that is affected. However, common symptoms include auras (sensory or emotional experiences that occur before a seizure), strange smells or tastes, lip-smacking or chewing movements, and memory problems. Some people with TLE may also experience automatisms (involuntary movements such as picking at clothes or fumbling with objects) during their seizures.

Treatment for TLE typically involves medication to control seizures, although surgery may be recommended in some cases. The goal of treatment is to reduce the frequency and severity of seizures and improve quality of life.

Lidocaine is a type of local anesthetic that numbs painful areas and is used to prevent pain during certain medical procedures. It works by blocking the nerves that transmit pain signals to the brain. In addition to its use as an anesthetic, lidocaine can also be used to treat irregular heart rates and relieve itching caused by allergic reactions or skin conditions such as eczema.

Lidocaine is available in various forms, including creams, gels, ointments, sprays, solutions, and injectable preparations. It can be applied directly to the skin or mucous membranes, or it can be administered by injection into a muscle or vein. The specific dosage and method of administration will depend on the reason for its use and the individual patient's medical history and current health status.

Like all medications, lidocaine can have side effects, including allergic reactions, numbness that lasts too long, and in rare cases, heart problems or seizures. It is important to follow the instructions of a healthcare provider carefully when using lidocaine to minimize the risk of adverse effects.

Flavin-Adenine Dinucleotide (FAD) is a coenzyme that plays a crucial role in various metabolic processes, particularly in the electron transport chain where it functions as an electron carrier in oxidation-reduction reactions. FAD is composed of a flavin moiety, riboflavin or vitamin B2, and adenine dinucleotide. It can exist in two forms: an oxidized form (FAD) and a reduced form (FADH2). The reduction of FAD to FADH2 involves the gain of two electrons and two protons, which is accompanied by a significant conformational change that allows FADH2 to donate its electrons to subsequent components in the electron transport chain, ultimately leading to the production of ATP, the main energy currency of the cell.

... withdrawal mimics delirium tremens and may be life-threatening. Amobarbital was manufactured by Eli Lilly and ... amobarbital > phenobarbital > barbital) It has an LD50 in mice of 212 mg/kg s.c.[citation needed] Amobarbital undergoes both ... The use of amobarbital as a truth serum has lost credibility due to the discovery that a subject can be coerced into having a " ... Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart in an attempt to preserve ...
The combination of clonazepam and certain barbiturates (for example, amobarbital), at prescribed doses has resulted in a ... Honer WG, Rosenberg RG, Turey M, Fisher WA (November 1986). "Respiratory failure after clonazepam and amobarbital". The ...
Examples of barbiturates are phenobarbital, primidone and amobarbital. Antihistamines, also known as H1 antagonists, are a ...
Patel A, Wordell C, Szarlej D (March 2011). "Alternatives to sodium amobarbital in the Wada test". The Annals of ... Jones-Gotman M, Sziklas V, Djordjevic J (August 2009). "Intracarotid amobarbital procedure and etomidate speech and memory test ...
Under the original CSA, no barbiturates were placed in schedule I, II, or V; however, amobarbital, pentobarbital, and ... The most commonly used are amobarbital (Amytal), pentobarbital (Nembutal), and secobarbital (Seconal). A combination of ... amobarbital, butalbital, cyclobarbital, and pentobarbital as schedule III, and allobarbital, barbital, butobarbital, ... Among that group of drugs are the barbiturates amobarbital, butalbital, cyclobarbital, and pentobarbital. In the United States ...
... and then responding dramatically to multigram doses of amobarbital. The films were convincing, and amobarbital was quickly and ... He and Lorenz found that intravenous sodium amytal (amobarbital) was effective in producing a "lucid interval," wherein ... Tollefson GD (1982). "The amobarbital interview in the differential diagnosis of catatonia". Psychosomatics. 23 (4): 437-438. ... Bleckwenn and Mabel Masten also studied the reversal of overdosage by amobarbital in the mid-1930s. They found that dilute ...
Examples include amobarbital, pentobarbital, phenobarbital, secobarbital, and sodium thiopental. Quinazolinones are also a ...
ISBN 0-465-02960-4. Loring, D.W., Meador, K.J., Lee, G.P., King, D.W. (1992). Amobarbital Effects and Lateralized Brain ... A barbiturate, usually sodium amobarbital, is introduced into one of the internal carotid arteries via a cannula or intra- ... The Wada test, also known as the intracarotid sodium amobarbital procedure (ISAP), establishes cerebral language and memory ...
Cameron suggests drugging her with amobarbital to suppress her thalamus. However, she continues to lie even on the amobarbital ...
Bartels, Jr., John R. (November 13, 1973). "Schedule II Control of Amobarbital, Pentobarbital, Secobarbital, and their salts" ( ...
Assessment of grammar optimizes language tasks for the intracarotid amobarbital procedure. Epilepsy & Behavior. 76:89-100. ...
Barbiturates more likely to cause euphoria include amobarbital, secobarbital and pentobarbital. Benzodiazepines more likely to ...
Tollefson GD: The amobarbital interview in the differential diagnosis of catatonia. Psychosomatics 1982; 23: 437-438. Bleckwenn ... These include ethanol, scopolamine, 3-quinuclidinyl benzilate, midazolam, flunitrazepam, sodium thiopental, and amobarbital, ... and amobarbital (formerly known as sodium amytal). While there have been many clinical studies of the efficacy of narcoanalysis ...
Horton was also in possession of the drugs Dexedrine, a stimulant, and Dexamyl, a stimulant-sedative; traces of amobarbital, an ...
Flynn Pharma of Ireland no longer manufactures Tuinal, Seconal or Amytal (amobarbital). Amytal has been discontinued, though ... The combination of a short-acting barbiturate, Secobarbital, with an intermediate-acting barbiturate, Amobarbital, aimed to ... secobarbital sodium and amobarbital sodium) in equal proportions. Tuinal was introduced as a sedative-hypnotic (sleeping pill) ...
Walker had allegedly been drinking before the outburst, and it was believed that the combination of amobarbital and alcohol ... She called Walker's psychiatrist Frederick Hacker, who arrived and administered amobarbital for sedation. ...
Use of sodium amobarbital with LSD to cause loss of inhibition.[page needed] Psychiatric drugs In the United States, in a ...
McCall, W. Vaughn M.D. "The Addition of Intravenous Caffeine During an Amobarbital Interview". Journal of Psychiatry and ... Narcosynthesis-also called sodium amytal interview, amobarbital interview, or amytal interview-uses a technique of free ...
... and hydrochlorothiazide have been known to interfere with amobarbital, which has led to inadequate anesthetization during the ... "Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting ...
Amobarbital Barbiturate Use of sodium amytal during WWII American Experience - The Battle of the Bulge. Thomas F. Lennon. 1994 ...
"Selective posterior cerebral artery amobarbital test: its role in presurgical memory assessment in temporal lobe epilepsy". ...
The test turns phenobarbital, pentobarbital, amobarbital and secobarbital light purple by complexation of cobalt with the ...
Some epilepsy centers use intracarotid sodium amobarbital test (Wada test), functional MRI (fMRI) or magnetoencephalography ( ...
People who use barbiturates tend to prefer rapid-acting barbiturates (amobarbital, pentobarbital, secobarbital) rather than ...
Originally in treatment for social anxiety and memory loss, after extended therapy involving amobarbital and hypnosis ...
Likewise a combination with amobarbital (potent sedative/hypnotic agent) for the amelioration of psychoneurosis and insomnia ...
An autopsy later showed a lethal combination of secobarbital and amobarbital, prescriptions for her insomnia and diet, which ...
The blood test also showed signs of amobarbital, which was possibly a residue from the Dexamyl pills that were found on ...
... as in amobarbital. A cyclopentyl group is a ring with the formula -C5H9. The name is also used for the pentyl radical, a pentyl ...
The Wada test, where sodium amobarbital is used to anaesthetise one hemisphere, shows that the left-hemisphere appears to be ...
  • Amobarbital (formerly known as amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. (wikipedia.org)
  • Amobarbital was manufactured by Eli Lilly and Company in the US under the brand name Amytal in bright blue bullet shaped capsules (known as Pulvules) or pink tablets (known as Diskets) containing 50, 100, or 200 milligrams of the drug. (wikipedia.org)
  • Amytal, as well as Tuinal, a combination drug containing equal quantities of secobarbital and amobarbital, were both manufactured by Eli Lilly until the late-1990s. (wikipedia.org)
  • Amobarbital was once manufactured in the US by Eli Lilly Pharmaceuticals under the brand name Amytal in capsule form. (wikipedia.org)
  • Sodium amytal (amobarbital, amylobarbitone, Amytal) is an intermediate-acting barbiturate. (espionageinfo.com)
  • Amobarbital is an intermediate-acting barbiturate with hypnotic properties used in short-term treatment of insomnia and to reduce anxiety and provide sedation preoperatively. (mayocliniclabs.com)
  • Amobarbital sodium, an intermediate-acting barbiturate, is a CNS depressant. (rxreasoner.com)
  • Anxiety Epilepsy Insomnia Wada test When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. (wikipedia.org)
  • In particular, in order to make amobarbital, α-ethyl-α-isoamylmalonic ester is reacted with urea (in the presence of sodium ethoxide). (wikipedia.org)
  • As with secobarbital sodium and pentobarbital sodium, other barbiturates (including amobarbital) might be expected to lose their effectiveness for inducing and maintaining sleep after about 2 weeks. (rxreasoner.com)
  • The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions. (mind42.com)
  • Sodium amobarbital and effects of frustrative nonreward. (bvsalud.org)
  • A 1988 study found that amobarbital increases benzodiazepine receptor binding in vivo with less potency than secobarbital and pentobarbital (in descending order), but greater than phenobarbital and barbital (in descending order). (wikipedia.org)
  • Mezerein (34807415), 12-o-tetradecanoylphorbol-13- acetate (544638), amobarbital (57432), butylated-hydroxytoluene (128370), phenobarbital (50066), butylated-hydroxyanisole (25013165), tryptophan (153946), and catechol (120809) inhibited metabolic cooperation between the wild type and mutant cells. (cdc.gov)
  • Amobarbital (5-ethyl-5-isoamylbarbituric acid), like all barbiturates, is synthesized by reacting malonic acid derivatives with urea derivatives. (wikipedia.org)
  • Amobarbital is a sedative hypnotic with anticonvulsant properties that interfere with the transmission of impulses from the thalamus to the cortex. (medscape.com)
  • barbital) It has an LD50 in mice of 212 mg/kg s.c.[citation needed] Amobarbital undergoes both hydroxylation to form 3'-hydroxyamobarbital, and N-glucosidation to form 1-(beta-D-glucopyranosyl)-amobarbital. (wikipedia.org)
  • Amobarbital is administered by intravenous infusion or intramuscular injection. (mayocliniclabs.com)
  • citation needed] If amobarbital is taken for extended periods of time, physiological and psychological dependence can develop. (wikipedia.org)
  • LSD and amobarbital did not reduce the proprioception. (erowid.org)
  • Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart in an attempt to preserve mitochondrial function following reperfusion. (wikipedia.org)
  • Amobarbital did not change the motor function while LSD improved and accelerated motor learning. (erowid.org)
  • According to notes from Kennedy's doctor, Kennedy took secobarbital and amobarbital to help him sleep. (sleepbetter.org)
  • Anxiety Epilepsy Insomnia Wada test When given slowly by an intravenous route, sodium amobarbital has a reputation for acting as a so-called truth serum. (wikipedia.org)
  • Our aim was to investigate the safety and efficacy of propofol relative to amobarbital in the Wada test. (nih.gov)
  • These findings support previous studies indicating that propofol is as safe and efficacious as amobarbital, and can continue to be used in Wada procedures with confidence. (nih.gov)
  • King, D. (1992) Amobarbital effects and lateralized Brain Function - The Wada Test . (bvsalud.org)
  • The duration of the drug effect during the intracarotid amobarbital procedure (IAP) is an important factor when considering the prioritization of behavioral testing during the IAP. (nih.gov)
  • Potential toxic effects of superselective injection of amobarbital sodium on microvasculature: a study in an animal model. (ajnr.org)
  • Previous studies of thiopental, a barbiturate similar to sodium amobarbital, found that age and gender significantly affect the dose required to induce anesthesia, such that younger patients require higher dosage. (nih.gov)
  • Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart in an attempt to preserve mitochondrial function following reperfusion. (wikipedia.org)
  • To determine if a higher dose of sodium amobarbital was needed for younger patients during the IAP, we analyzed the time to return to preinjection EEG baseline status and time to return to 5/5 strength as a function of patient age and gender. (nih.gov)
  • The sodium amobarbital effect during IAP dissipates faster in young patients. (nih.gov)
  • Propofol produced similar lateralization rates as amobarbital for both language and memory. (nih.gov)
  • Sodium-cyclamate (139059), tryptophan (153946), and amobarbital (57432) showed ambiguous or weakly positive results. (cdc.gov)