Organisms
AristolochiaceaeAristolochia
Aristolochiaceae
A plant family of the order Aristolochiales subclass Magnoliidae class Magnoliopsida. They are mostly tropical woody vines and a few temperate-zone species. The flowers are 3-parted; some species lack petals while others are large and foul smelling.
Aristolochia
A plant genus of the family ARISTOLOCHIACEAE. Species of this genus have been used in traditional medicine but they contain aristolochic acid which is associated with nephropathy. These are sometimes called 'snakeroot' but that name is also used with a number of other plants such as POLYGALA; SANICULA; ASARUM; ARISTOLOCHIA; AGERATINA; and others.

Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis. (1/3)

Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7'R,8S,8'S)-3',4'-methylenedioxy-4,5-dimethoxy-2,7'-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of < or =0.32 microM. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.  (+info)

The shape of things to come: woodland herb niche contraction begins during recruitment in mesic forest microhabitat. (2/3)

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4,5-seco-guaiane and a nine-membered sesquiterpene lactone from Holostylis reniformis. (3/3)

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Aristolochiaceae is a family of flowering plants that includes mostly climbing or creeping herbs and shrubs, characterized by their unique, often complex-shaped flowers which trap insects to ensure pollination, and many of which contain aristolochic acids that have been linked to kidney damage and cancer.

Aristolochiaceae is a family of flowering plants that includes around 600 species, distributed mainly in temperate and tropical regions. These plants are known for their unique, often tube-shaped flowers, which have evolved to attract specific pollinators such as flies and beetles. Some members of this family contain aristolochic acids, which have been found to be nephrotoxic and carcinogenic in animals and humans. As a result, several species of Aristolochiaceae are considered potentially harmful and have been restricted or banned in some countries.

The medical relevance of Aristolochiaceae lies mainly in its potential toxicity. Exposure to aristolochic acids through the ingestion of plant material or contaminated food and herbal remedies has been linked to kidney damage, chronic interstitial nephritis, and urothelial cancer. The use of Aristolochiaceae-containing products for medicinal purposes is therefore discouraged, and alternative treatments should be sought.

It's important to note that the medical community continues to research and monitor the potential health risks associated with Aristolochiaceae and its compounds. Healthcare professionals should stay informed about any updates or developments in this area to ensure the safety and well-being of their patients.

'Aristolochia' is a genus of primarily tropical herbaceous plants and vines, also known as birthworts, that have been used in traditional medicine but are now known to contain aristolochic acids which can cause kidney failure and urothelial cancer.

"Aristolochia" is a genus of flowering plants in the family Aristolochiaceae, also known as birthworts. These plants are characterized by their unique, pipe-shaped flowers. Some species of Aristolochia contain aristolochic acids, which have been found to be nephrotoxic and carcinogenic. Because of this, the use of these plants in medicinal preparations is generally discouraged or restricted.

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