Ventricular remodeling

Telocyte

Sarcolipin

MIRN21

Atrial natriuretic peptide

Atrial fibrillation

XEN-D0101

Left atrial volume

3,5-Diiodothyronine

Euthyroid sick syndrome

Sum activity of peripheral deiodinases

Mir-590 microRNA precursor family

Mir-133 microRNA precursor family

MYL7

Endothelin 2

Catheter ablation

Cardiac skeleton

Ameca, Jalisco

Endocardial cushions

Hypertensive heart disease

Management of heart failure

PCSK6

Budiodarone

MMP9

Roberta Gottlieb

Sinus node dysfunction

CORIN

Efonidipine

TBX5 (gene)

Right bundle branch block

Including atrial fibrillation2

• Maximal left atrial volume measured echocardiographically in population-based studies is an independent determinant of cardiovascular events, including atrial fibrillation, congestive heart failure, and stroke. (medscape.com)
• It is well known that angiotensin-converting enzyme (ACE) inhibitors and angiotensin-II type I receptor blockers (ARBs) are not only effective in treating hypertension but also in reducing the morbidity and mortality in various disease conditions including atrial fibrillation (AF), 1 coronary artery disease (CAD), 2 and congestive heart failure (CHF). (jafib.com)

Arrhythmia12

• Abhayaratna and coworkers prospectively studied 574 adults older than 65 (mean age 74±6) in sinus rhythm without a history of atrial arrhythmia, stroke, valvular or congenital heart disease that were referred for a clinically indicated echocardiogram. (medscape.com)
• the prevalence of hypertension, diabetes, heart failure, prior myocardial infarction and the use of cardioactive medications were similar in those with and without atrial arrhythmia. (medscape.com)
• The maximum LA volume (47±17 vs. 40±14 ml/m 2 ) and minimum LA volume (29±3 vs. 21±9 ml/m 2 ) were greater and the LA emptying index was less (38± 12% vs. 49± 11%), and grade II-IV diastolic dysfunction was more common (37 vs. 19%) in those with than without a first atrial arrhythmia. (medscape.com)
• After correcting for age, LA emptying fraction = 49% (HR 6.5) and LA maximum volume = 38 ml/m 2 (HR 2.0) predicted atrial arrhythmia, and both were independent predictors in a multivariable analysis that controlled for baseline clinical variables, LV ejection fraction and diastolic dysfunction. (medscape.com)
• They speculate that abnormal reservoir function (functional or mechanical remodeling) represents a more advanced stage of atrial remodeling than atrial size alone (structural remodeling), and that the remodeling process is a determinant of atrial arrhythmia, independent from clinical risk factors and LV function. (medscape.com)
• Recognition of electrical remodeling as a phenomenon provides new opportunities for development of novel arrhythmia control and prevention strategies before persistent changes occur. (nih.gov)
• However, if often causes disease of the myocardium, such as heart failure, linked to the severity of DMR, and ventricular or atrial dysfunction or arrhythmia. (nih.gov)
• The changes in left atrial (LA) size and function are related to the occurrence of arrhythmia. (researchsquare.com)
• The exclusion criteria in both groups included cardiovascular disease, such as history of atrial arrhythmia, hypertrophic cardiomyopathy, and severe valvular disease, and poor image quality for myocardial speckle tracing analysis. (researchsquare.com)
• Atrial fibrillation is the most common type of cardiac arrhythmia. (nih.gov)
• Atrial fibrillation represents the most common arrhythmia leading to increased morbidity and mortality, yet, current treatment strategies have proven inadequate. (nih.gov)
• Segment of an ECG showing atrial fibrillation, a rapid arrhythmia of the heart. (medscape.com)

Arrhythmias7

• PURPOSE The objective of this initiative is to elucidate mechanisms responsible for functional, molecular, and structural myocardial changes due to electrical remodeling and leading to arrhythmias. (nih.gov)
• Our simulations complement and extend previous studies aimed at understanding key factors by which decreases in [K + ] o can produce effects that are known to promote atrial arrhythmias in human hearts. (frontiersin.org)
• Atrial fibrillation (AF) is one of the most common arrhythmias and associated with heart failure [ 1 - 4 ]. (hindawi.com)
• Experimental and clinical evidence suggests that mechanical stress leads to myocardial inflammation, fibrosis, and remodeling that creates the electrophysiological substrate responsible for SCA/SCD and other serious ventricular arrhythmias. (nih.gov)
• Lower heart rate is associated with preservation of energy substrate in the myocardium, allowing reverse remodeling, and may result in fewer arrhythmias. (medpagetoday.com)
• Atrial fibrillation is one of the most common arrhythmias, affecting between 3 and 6 million adults in the US. (msdmanuals.com)
• 3] Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias . (nih.gov)

Development of electrocardiographi1

• [ 6 ] The patients were followed for 1.9±1.2 years for the development of electrocardiographically-confirmed atrial fibrillation or flutter using questionnaires and review of medical records. (medscape.com)

Recurrence5

• Influence of left ventricular remodeling on atrial fibrillation recurrence and cardiovascular hospitalizations in patients undergoing rhythm-control therapy. (nih.gov)
• Post-cardioversion time Course of Atrial Remodeling Markers and their Association with Recurrence in Subjects with Long-standing, Persistent Atrial Fibrillation. (bvsalud.org)
• Activation of the renin - angiotensin - aldosterone axis with elevation of inflammatory markers and the resulting fibrosis play a very important role in atrial remodeling in patients with atrial fibrillation (AF), which is associated with post- cardioversion recurrence . (bvsalud.org)
• 5. Left atrial strain for predicting recurrence in patients with non-valvular atrial fibrillation after catheter ablation: a single-center two-dimensional speckle tracking retrospective study. (nih.gov)
• The primary endpoints were defined as a new development and/or recurrence of atrial fibrillation (AF). (jafib.com)

Structural7

• I coordinate studies on electrical, contractile, and structural remodeling in heart failure and atrial fibrillation. (maastrichtuniversity.nl)
• miRNAs play a variety of roles in atrial fibrillation, including regulation of electrical remodeling and modulation of structural remodeling of cardiac tissue. (hindawi.com)
• Therefore, in the first part of the thesis, we studied early hypertension-induced structural and functional (Ca2+ handling) remodeling of left ventricular (LV) myocytes and nuclei. (uni-marburg.de)
• In the second part of the thesis, we studied structural and functional nuclear remodeling in advanced hypertension. (uni-marburg.de)
• It had been suggested that omega-3 fatty acids and vitamin D might prevent Afib due to their electrophysiologic effects on atrial structural and electrical remodeling. (medpagetoday.com)
• Therefore, the goal of the study is to directly test the hypotheses that inhibition of the soluble epoxide hydrolase enzyme can result in an increase in the levels of epoxyeicosatrienoic acids, leading to the attenuation of atrial structural and electric remodeling and the prevention of atrial fibrillation.For the first time, we report findings that inhibition of soluble epoxide hydrolase reduces inflammation, oxidative stress, atrial structural, and electric remodeling. (nih.gov)
• Proarrhythmic atrial structural and molecular remodeling with advancing age. (escardio.org)

Echocardiography9

• Using the American Society of Echocardiography (ASE) criteria, patients were divided into 4 categories: 1) normal geometry, 2) concentric remodeling, 3) eccentric hypertrophy, and 4) concentric hypertrophy. (nih.gov)
• ECG gated Echocardiography with measurement of atrial electromechanical coupling (PA), left atrial intra-AEMD over a period of 1 year from July 2017 to July 2018 in Mansoura specialized medical hospital. (scirp.org)
• Determining electromechanical intervals as the atrial conduction interval with transthoracic echocardiography is a simple, easy bedside method to be evaluated. (scirp.org)
• The whole patients were assessed by way of thorough records taking, medical examination, twelve lead surface (ECG), ECG gated echocardiography with assessment of atrial electromechanical coupling (PA), left atrial intra-AEMD over a period of 1 year from July 2017 to July 2018 in department of cardiovascular medicine, Faculty of Medicine, Mansoura University. (scirp.org)
• 8. Interaction effect of hypertension and obesity on left atrial phasic function: a three-dimensional echocardiography study. (nih.gov)
• 13. Left atrial reservoir strain is an outstanding predictor of adverse cardiovascular outcomes in patients undergoing maintenance hemodialysis: Assessment via three-dimensional speckle tracking echocardiography. (nih.gov)
• 18. Real-time three-dimensional echocardiography of left atrial volume and function in patients with severe multi-vessel coronary artery disease. (nih.gov)
• The present study was designed to measure LA conventional echocardiography and LA strain and strain rate parameters in patients with paroxysmal atrial fibrillation, then to analyze the difference between stroke/ transient ischemic attack (TIA) and non-stroke/TIA patients, and to explore relationship between the impaired deformability of LA and stroke/TIA events and its predictive value for stroke/TIA events. (researchsquare.com)
• The study enrolled 365 consecutive patients (222 were male, 58.95±10.52 years old) who underwent pre-procedural transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) before radiofrequency catheter ablation (RFCA) for symptomatic drug-refractory paroxysmal AF in Beijing Anzhen Hospital Atrial fibrillation center, Capital Medical University from January 2017 to June 2020. (researchsquare.com)

Myocardial6

• A common scenario for remodeling is after myocardial infarction. (wikipedia.org)
• The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
• MVP can lead to excessive mechanical stress on the ventricles and the atria, and possibly to myocardial inflammation, fibrosis, and remodeling. (nih.gov)
• Here, we assessed the medium-term electrophysiologic remodeling after intra-myocardial GH administration in (n = 33) rats. (researchgate.net)
• Growth hormone, currently under evaluation for the prevention of left ventricular remodeling post-myocardial infarction, displays antiarrhythmic properties in the acute setting. (researchgate.net)
• Dysregulation of miR1 has been associated with various heart diseases, where a significant reduction (>75%) in miR1 expression has been observed in patient hearts with atrial fibrillation or acute myocardial infarction. (cdc.gov)

Risk of atrial fibrillation2

• 1-6 The impact of physical activity on the risk of atrial fibrillation (AF) appears to be more complex. (bmj.com)
• The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis. (cdc.gov)

Causes of atrial fibrillation1

• There are many causes of atrial fibrillation (AF), but it shares a strong association with other cardiovascular diseases. (nih.gov)

Etiology of atrial fibrillation1

• Identify the etiology of atrial fibrillation. (nih.gov)

Reduced in patients with atrial1

• Indeed, reservoir function calculated using atrial strain and strain rates during ventricular systole (measures of atrial distensibility and reservoir capacity, respectively) were reduced in patients with atrial fibrillation compared with controls and predicted independently the maintenance of sinus rhythm after cardioversion. (medscape.com)

Management of atrial fibrillation1

• This activity describes the evaluation, diagnosis, and management of atrial fibrillation and highlights the role of team-based interprofessional care for affected patients. (nih.gov)

Leads to atrial2

• It is associated with atrial remodeling that finally leads to atrial fibrillation (AF). (scirp.org)
• Although rate control is important to stabilizing patients with AF, restoring sinus rhythm can slow or reverse the atrial and ventricular remodeling that leads to atrial dilation and left ventricular dysfunction. (medscape.com)

Myocardium2

• Especially interested on investigating novel therapeutic approaches to achieve functional recovery through enhancing the reparative processes of the of the damaged myocardium and reversal of adverse heart remodeling. (biomedcentral.com)
• Main research topics are: Adaptation processes of excitation-contraction coupling in ventricular and atrial myocardium, cellular and integrated action of antiarrhythmic drugs, and the development of substrates for the perpetuation of atrial fibrillation. (maastrichtuniversity.nl)

Patients28

• This was a cross-sectional study in patients with idiopathic atrial fibrillation. (revespcardiol.org)
• Myocytes were isolated enzymatically from the right atrial appendage of 40 consenting patients who were in sinus rhythm. (gla.ac.uk)
• 11-13 patients) was not associated with any significant changes in atrial cell electrophysiology. (gla.ac.uk)
• BACKGROUND: Atrial fibrillation (AF) patients with left ventricular hypertrophy (LVH) and diastolic dysfunction may derive benefit from being in sinus rhythm but no data are available to support this strategy in them. (nih.gov)
• We sought to investigate effect of left ventricular remodeling on cardiovascular outcomes in AF patients undergoing rhythm control strategy. (nih.gov)
• Ventriculoatrial remodeling in patients with recurrent atrial fibrillation and diastolic dysfunction: does gender matter? (rudn.ru)
• among them, 221 (61%) were in sinus rhythm and had no prior atrial fibrillation (AF), and 144 patients (39%) had a history of AF. (rug.nl)
• Cox regression analysis revealed that patients with no atrial and no ventricular reverse remodelling had the worst outcome (hazard ratio 3.1, 95% confidence interval 1.4-7.1, P = 0.006). (rug.nl)
• Outcome in patients with only atrial reverse remodelling was comparable with outcome in patients with both atrial and ventricular reverse remodelling (hazard ratio 2.0, 95% confidence interval 0.7-5.6, P = 0.21). (rug.nl)
• Patients without atrial and ventricular reverse remodelling have the worst outcome. (rug.nl)
• Patients with only atrial reverse remodelling have improved left ventricular diastolic filling during follow-up and demonstrate a comparable outcome with patients with both atrial and ventricular reverse remodelling. (rug.nl)
• abstract = "To study the prognostic effect of atrial reverse remodelling on outcome of cardiac resynchronization therapy (CRT).Patients receiving a CRT device in the University Medical Centre Groningen were included. (rug.nl)
• Other anatomic considerations in evaluating patients prior to PMBV include exclusion of left atrial thrombus and severe mitral regurgitation , both of which are contraindications to the procedure (see Contraindications section below). (medscape.com)
• Increased AEMDs can be used as indicators to differentiate patients with recent onset atrial fibrillation from controls without recent onset AF or to expect the occurrence of recent attack of AF as in studies [1]. (scirp.org)
• 1. Four-dimensional quantification on left atrial volume-strain in coronary heart disease patients without regional wall motion abnormalities: Correlation with the severity of coronary stenosis. (nih.gov)
• 2. Echocardiographic evaluation of left atrial strain for predicting iron overload in pediatric patients with β-thalassemia with preserved ejection fraction. (nih.gov)
• 4. Correlation of left atrial strain with left ventricular end-diastolic pressure in patients with normal left ventricular ejection fraction. (nih.gov)
• 9. Left atrial reservoir strain combined with E/E' as a better single measure to predict elevated LV filling pressures in patients with coronary artery disease. (nih.gov)
• 17. Decreased left atrial function in obesity patients without known cardiovascular disease. (nih.gov)
• Approximately in half of the patients after coronary artery bypass surgery, atrial fibrillation (AF) is developed. (nature.com)
• First, patients with AF may require a higher heart rate to counteract the diminished stroke volume due to the loss of atrial kick. (medpagetoday.com)
• Aim: Peri-procedural thromboembolic (TE) and hemorrhagic events are complications of major concern for patients undergoing cryoballoon (CB) ablation for atrial fibrillation (AF). (researchgate.net)
• Although atrial fibrillation may be a permanent disease, various treatments and risk modifying strategies have been developed to help reduce the risk of stroke in patients that remain in atrial fibrillation. (nih.gov)
• Explain the interprofessional team strategies for improving care coordination and communication regarding the management of patients with atrial fibrillation. (nih.gov)
• Stroke is a kind of serious complication in patients with atrial fibrillation (AF). (researchsquare.com)
• When Should Anticoagulation for Stroke be Initiated in Patients With Atrial Fibrillation? (medscape.com)
• Atrial fibrillation tends to occur in patients with an underlying heart disorder. (msdmanuals.com)
• Permanent atrial fibrillation cannot be converted to sinus rhythm (the term also includes patients for whom a decision has been made not to attempt conversion to sinus rhythm). (msdmanuals.com)

Inflammation2

• She is now pursuing research interests in treating inflammation and obesity to help manage atrial fibrillation, while training in clinical cardiology. (biomedcentral.com)
• Any condition that leads to inflammation, stress, damage, or ischemia affecting the anatomy of the heart can result in the development of atrial fibrillation. (nih.gov)

Ablation1

• Following, Vennela worked as a PhD research fellow at Imperial College London running a multi-centre randomised controlled trial comparing ablation strategies in non-paroxysmal atrial fibrillation, which was funded by National Institute of Health Research (NIHR). (biomedcentral.com)

Myocytes2

• We utilized the patch clamp technique to characterize the electrical remodelling associated with enhanced TRPC3 expression in cardiac myocytes. (biomedcentral.com)
• Besides, reduced expression of V1 myosin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodeling. (wikipedia.org)

Mitral regurgitation2

• Michael Haude, MD, PhD. Percutaneous Coronary Sinus-Based Mitral Valve Annuloplasty in Atrial Functional Mitral Regurgitation. (cardiacdimensions.com)
• Transcatheter indirect mitral annuloplasty induces annular and left atrial remodelling in secondary mitral regurgitation. (cardiacdimensions.com)

Coronary1

• Implications for post-coronary artery bypass grafting atrial fibrillation occurrence. (escardio.org)

Abstract1

• abstract = "Prevalence rates of atrial fibrillation (AF) and obstructive sleep apnea (OSA) are rising on a global scale. (edu.au)

Substrate3

• Studies of atrial fibrillation (AF) due to atrial tachycardia have provided insights into the remodeling mechanisms by which "AF begets AF" but have not elucidated the substrate that initially supports AF before remodeling occurs. (nih.gov)
• A progressive shift in intracellular [Na + ] i causes a change in the outward electrogenic current generated by the Na + /K + pump, thereby modifying V r and AP repolarization and changing the human atrial electrophysiological substrate. (frontiersin.org)
• Atrial fibrillation substrate mapping with decrement evoked potential mapping. (escardio.org)

Fibrillation include1

• Risk factors for atrial fibrillation include advanced age, high blood pressure, underlying heart and lung disease, congenital heart disease, and increased alcohol consumption. (nih.gov)

Electrophysiology1

• Workman, A.J. , Kane, K.A. , Russell, J.A. , Norrie, J. and Rankin, A.C. (2003) Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. (gla.ac.uk)

Diastolic2

• The importance of atrial compliance and reservoir function in normal physiology is well documented: the dissipation of energy stored in the left atrium during ventricular systole acts a restorative force during early diastolic LV filling, and atrial compliance is an important determinant of atrial systolic shortening and cardiac performance. (medscape.com)
• Left atrial pressure is determined by the transvalvular gradient, which is a function of both orifice area and diastolic filling time. (medscape.com)

Cardiovascular2

• We aimed to investigate electrophysiological changes in human atrial cells associated with chronic treatment with β-blockers and other cardiovascular-acting drugs. (gla.ac.uk)
• The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production associated with exchange protein directly activated by cAMP (EPAC) proteins. (uni-regensburg.de)

Valvular heart d1

• Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. (wikipedia.org)

Genomic1

• Genomic contributors to atrial electroanatomical remodeling and atrial fibrillation progression: Pathway enrichment analysis of GWAS data. (cdc.gov)

Progression2

• We hypothesized that maladaptive remodeling of nuclear structure and nuclear Ca2+ signaling might occur early in hypertension triggering initiation and progression of hypertrophy, and in advanced hypertension contributing to the transition from compensated hypertrophy to heart failure. (uni-marburg.de)
• The observed remodeling of nuclear Ca2+ handling might represent an early event in hypertension that contributes to initiation and progression of pathological hypertrophy in hypertensive heart disease. (uni-marburg.de)

Associated with maladaptive2

• Our results suggest a pivotal role of TRPC channels in cardiac electrical remodelling associated with maladaptive hypertrophy. (biomedcentral.com)
• 0.0001) protein imbalance associated with maladaptive remodeling. (uni-regensburg.de)

Cardiac resynch1

• To study the prognostic effect of atrial reverse remodelling on outcome of cardiac resynchronization therapy (CRT). (rug.nl)

Electrical7

• Action potential-clamp experiments as well as mathematical modelling attempts were performed to delineate the consequences of TRPC3 overexpression and to analyze the mechanisms of TRPC3-mediated electrical remodelling in the heart. (biomedcentral.com)
• Ninety-nine subjects with long-standing, persistent, non-valvular atrial fibrillation who underwent successful electrical cardioversion were included, with a 6 month follow up. (bvsalud.org)
• Electrical remodeling represents a persistent alteration in cardiac characteristics after a temporary, abnormal heart rhythm change. (nih.gov)
• For instance, electrical remodeling accounts for the maintained shortening of atrial refractoriness after transient heart rate increases. (nih.gov)
• Atrial electromechanical coupling delays are the time intervals between the electrical depolarization of the atria and start of atrial mechanical activity. (scirp.org)
• Prolonged Atrial electromechanical delay reflects the electrical remodeling of the left atrium, which is important for maintenance of AF [2]. (scirp.org)
• In atrial fibrillation, the atria do not contract, and the atrioventricular (AV) conduction system is bombarded with many electrical stimuli, causing inconsistent impulse transmission and an irregularly irregular ventricular rate, which is usually in the tachycardia rate range. (msdmanuals.com)

Mechanisms3

• We have used mathematical models of the human atrial action potential (AP) to explore the electrophysiological mechanisms that underlie changes in resting potential (V r ) and the AP following decreases in plasma K + , [K + ] o , that were selected to mimic clinical hypokalemia. (frontiersin.org)
• In 2003, he defended his thesis "Mechanisms of Atrial Paralysis in Atrial Fibrillation" at Maastricht University. (maastrichtuniversity.nl)
• Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. (nih.gov)

Natriuretic4

• Activation of the renin-angiotensin-system seems to be involved in atrial enlargement, with release of atrial and brain natriuretic peptides. (revespcardiol.org)
• The aim of this study was to evaluate the relationship between ambulatory blood pressure and levels of natriuretic peptides, with left atrial size in normotensives with idiopathic atrial fibrillation. (revespcardiol.org)
• The following measurements were recorded during the course of the study: office and 24-h ambulatory blood pressure, atrial and brain natriuretic peptides, plasma renin, aldosterone, and angiotensin-converting enzyme. (revespcardiol.org)
• However, atrial natriuretic peptide is thought to be cardio-protective. (wikipedia.org)

Hypertension1

• Hypertension is a risk factor for atrial fibrillation. (revespcardiol.org)

Strain4

• 3. Prognostic Value of Left Atrial Strain in Aortic Stenosis: A Competing Risk Analysis. (nih.gov)
• 6. Impact of different degrees of left ventricular strain on left atrial mechanics in heart failure with preserved ejection fraction. (nih.gov)
• 10. The novel left atrial strain parameters in diagnosing of heart failure with preserved ejection fraction. (nih.gov)
• Our group has demonstrated a reduction in the LV global longitudinal strain in strength athletes, which was analyzed using the non-invasive pressure-strain loop area, LV remodeling, and subclinical changes in LV systolic function[3]. (researchsquare.com)

Systolic2

• Success of CRT was defined as ventricular reverse remodelling with a reduction in left ventricular end-systolic volume of a parts per thousand yen15% at 6-month follow-up. (rug.nl)
• Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. (wikipedia.org)

Maladaptive2

• Both EPAC2 and ST2 expression were directly related to maladaptive heart remodeling indices, suggesting EAT measurements could be useful in the early assessment of CVD complications. (uni-regensburg.de)
• Initially, hypertrophy is beneficial, but chronic activation of neurohormonal mediators and altered Ca2+ signaling ultimately lead to maladaptive alterations in gene expression and progressive cardiac remodeling, which eventually becomes detrimental and impairs cardiac function. (uni-marburg.de)

Conduction1

• however, CHF dogs had a substantial increase in the heterogeneity of conduction during atrial pacing (heterogeneity index in CHF dogs, 2. (nih.gov)

Involved in cardiac2

• Besides, the cardiac interstitium which consisted of largely Type I and Type III collagen fibres are also involved in cardiac remodeling. (wikipedia.org)
• Two important Ca2+-dependent signaling pathways involved in cardiac remodeling are the Ca2+/calmodulin-dependent protein phosphatase calcineurin (CaN)-NFAT-GATA4/6 and the Ca2+/calmodulin-dependent protein kinase II (CaMKII)-HDAC-MEF2 pathway. (uni-marburg.de)

Abnormalities1

• Atrial conductivity abnormalities were evaluated by simple non-invasive strategies with the use of electrocardiography and tissue Doppler imaging (TDI) as in previous studies [8] [9]. (scirp.org)

Heart11

• In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. (wikipedia.org)
• This can happen as a result of exercise (physiological remodeling) or after injury to the heart muscle (pathological remodeling). (wikipedia.org)
• Over time, however, as the heart undergoes ongoing remodeling, it becomes less elliptical and more spherical. (wikipedia.org)
• Remodeling of the heart is evaluated by performing an echocardiogram. (wikipedia.org)
• With exercise, heart rate and cardiac output increase, leading to an increase in left atrial and pulmonary arterial pressures. (medscape.com)
• Mild reduction, with MVA measuring 2.0-2.5 cm 2 , results in elevated left atrial pressures when blood flow or heart rate is increased. (medscape.com)
• Does left atrial volume affect exercise capacity of heart transplant recipients? (uc.edu)
• LA remodeling is an integral part of the "athlete's heart" that is often ignored. (researchsquare.com)
• CONCLUSIONS: miR1 deficiency acts as a primary etiological factor in inducing cardiac remodeling via disrupting heart regulatory homeostasis. (cdc.gov)
• Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE . (bvsalud.org)
• 1] Mitochondrial ROS drive sudden cardiac death and chronic proteome remodeling in heart failure . (nih.gov)

Prevention1

• Neither fish oil nor vitamin D supplementation worked in the long-term primary prevention of atrial fibrillation (Afib), according to the VITAL Rhythm study. (medpagetoday.com)