Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Infarctions that occur in the BRAIN STEM which is comprised of the MIDBRAIN; PONS; and MEDULLA OBLONGATA. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
Progenitor cells from which all blood cells derive.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Cells with high proliferative and self renewal capacities derived from adults.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Selective innervation of retinorecipient brainstem nuclei by retinal ganglion cell axons regenerating through peripheral nerve grafts in adult rats. (1/149)

The pattern of axonal regeneration, specificity of reinnervation, and terminal arborization in the brainstem by axotomized retinal ganglion cell axons was studied in rats with peripheral nerve grafts linking the retina with ipsilateral regions of the brainstem, including dorsal and lateral aspects of the diencephalon and lateral aspect of the superior colliculus. Four to 13 months later, regenerated retinal projections were traced using intraocular injection of cholera toxin B subunit. In approximately one-third of the animals, regenerated retinal axons extended into the brainstem for distances of up to 6 mm. Although axons followed different patterns of ingrowth depending on their site of entry to the brainstem, within the pretectum, they innervated preferentially the nucleus of the optic tract and the olivary pretectal nucleus in which they formed two types of terminal arbors. Within the superior colliculus, axons extended laterally and formed a different terminal arbor type within the stratum griseum superficiale. In the remaining two-thirds of the animals, retinal fibers formed a neuroma-like structure at the site of entry into the brainstem, or a few fibers extended for very short distances within the neighboring neuropil. These experiments suggest that regenerated retinal axons are capable of a highly selective reinnervation pattern within adult denervated retinorecipient nuclei in which they form well defined terminal arbors that may persist for long periods of time. In addition, these studies provide the anatomical correlate for our previous functional study on the re-establishment of the pupillary light reflex in this experimental paradigm.  (+info)

Radiation therapy and high-dose tamoxifen in the treatment of patients with diffuse brainstem gliomas: results of a Brazilian cooperative study. Brainstem Glioma Cooperative Group. (2/149)

PURPOSE: The efficacy of radiation therapy (RT) combined with tamoxifen (TX) was tested in patients diagnosed with diffuse brainstem gliomas in a multicenter trial. PATIENTS AND METHODS: TX was administered orally (maintenance dose: 200 mg/m(2) per day) along with conventional local RT and then continued for 52 additional weeks. Survival, tumoral radiologic response, and toxicity were evaluated. Compliance was assessed using pharmacokinetic measurements. RESULTS: Of 29 patients, 27 completed RT (median dose, 54 Gy). Of 22 assessable patients, 11 (50%) had an objective radiologic response. The mean TX steady-state serum level was 2.44 micromol/L +/- 1.02 micromol/L. Only three patients completed the entire course of treatment without tumoral progression or significant toxicity. Common side effects included nausea and vomiting. Hepatotoxicity (five patients), neurotoxicity (two patients), venous thrombosis (one patient), bilateral ovarian cysts (two patients), and transient neutropenia (one patient) were also observed. Median survival was 10.3 months. Only four patients remain alive without tumoral progression. The 1-year survival rate (mean +/- SD) was 37.0% +/- 9.5%. CONCLUSION: This treatment combination produced no significant change in the overall poor prognosis of these patients. Most tumors responded initially to treatment but recurred as the study progressed. A minority of patients seemed to benefit from the extended use of TX. Generally, treatment was well tolerated, with good patient compliance, but we recommend continuous close monitoring for side effects. Based on our poor results, we recommend that alternative treatments be tested in patients with this type of tumor.  (+info)

Intramedullar stimulation of the facial and hypoglossal nerves: estimation of the stimulated site. (3/149)

AIM: To determine the stimulation site of both facial and hypoglossal nerves after transcranial magnetic stimulation. METHODS: After surgical exposure of the brainstem in 22 patients with intrinsic pontine (n=9) or medullary (n=13) tumors, the facial colliculus and the hypoglossal triangle were electrically stimulated. The EMG responses were recorded with flexible wire electrodes from the orbicularis oculi/orbicularis oris muscles, and genioglossal muscles. Patients had no preoperative deficit of the nerves. RESULTS: The EMG mean latencies of the unaffected facial nerve were 5.2+/-0.6 ms for the orbicularis oculi, and 5.2+/-0.5 ms for the orbicularis oris muscle. After the stimulation of 18 possibly affected facial nerves, the EMG mean latencies were 5.3+/-0.3 ms for the orbicularis oculi (p=0.539, unpaired Student's t-test), and 5.4+/-0.2 ms for the orbicularis oris (p=0.122). The EMG mean latency of the unaffected hypoglossal nerve was 4.1+/-0.6 ms for the genioglossal muscle. After the stimulation of 26 possibly affected hypoglossal nerves, the EMG mean latency for the genioglossal muscle was 5.3+/-0.3 ms. There was a significant difference (p<0.001) in latency for genioglossal EMG responses between the patients with pontine and those with medullary tumors. CONCLUSION: Shorter EMG mean latencies of unaffected facial nerves obtained after direct stimulation of the facial colliculi confirm that magnetic stimulation is most likely to occur closer to the nerve's exit from the brainstem than to its entrance into the internal auditory meatus. The hypoglossal nerve seems to have the site of excitation at the axon hillock of the hypoglossal motor neurons.  (+info)

Intra-axial tumors of the medullocervical junction: diagnosis and microsurgical treatment. (4/149)

OBJECTIVE: To describe the clinical features, operative methods and postoperative management of the intra-axial tumors of medullocervical junction, and to make differential diagnosis for different subtypes. METHODS: Fifteen patients with intra-axial tumors of medullocervical junction were treated from August 1988 to June 1997. The diagnoses were confirmed by MRI and histological examinations. The tumors were divided into two subtypes according to the clinical features and the main body of the tumor. The distinctive points of the two subtypes and the appropriate surgical methods of different pathological type tumors were expounded. RESULTS: Tumors were totally removed in 10 patients and subtotally in 5. There was no death caused by operation. Postoperative complications included respiratory disturbance in six cases, upper digestive tract bleeding in one, depressed cough reflex in two, most of which recovered after proper treatment. On discharge, the nervous system status was improved in 11 cases, stable in 2 and worsened in 2. CONCLUSIONS: The intra-axial tumors of medullocervical junction can be divided into cervicomedullary and medullocervical subtypes. The MRI examination is decisive in the distinction of the diagnosis, and is important in the determination of the nature of the medullar cystic lesions and the guidance of the resection of tumor extent. The cervicomedullary tumors are more amenable to an aggressive surgical treatment, during which the surgeon should remove the tumors first in the cervical spinal cord area, then in the medullar area with the tumor resection expanding rostrally. It can make the operation safer to remove the tumors using appropriate techniques varied with pathological types of the tumors. Managing postoperative respiratory disturbances without delay is one of the important points in improving the therapeutic effect.  (+info)

Paroxysmal alternating skew deviation and nystagmus after partial destruction of the uvula. (5/149)

A patient with suspected brain stem glioma involving the area of the left vestibular nuclei and cerebellar peduncle, developed paroxysmal alternating skew deviation and direction changing nystagmus after biopsy of the inferior cerebellar vermis resulting in destruction of the uvula. Between attacks she had right over left skew deviation with asymptomatic right beating horizontal nystagmus. Slow phases of the resting nystagmus showed increasing velocity, similar to congenital nystagmus. At intervals of 40-50 seconds, paroxysmal reversal of her skew deviation occurred, accompanied by violent left beating horizontal torsional nystagmus lasting 10-12 seconds and causing severe oscillopsia. It is proposed that this complex paroxysmal eye movement disorder results from (1) a lesion in the left vestibular nuclei causing right over left skew and right beating resting nystagmus and (2) a disruption of cerebellar inhibition of vestibular nuclei, causing alternating activity in the vestibular system with intermittent reversal of the skew deviation and paroxysmal nystagmus towards the side of the lesion.  (+info)

Perfusion-sensitive MR imaging of gliomas: comparison between gradient-echo and spin-echo echo-planar imaging techniques. (6/149)

BACKGROUND AND PURPOSE: The different sensitivities to vessel size of gradient-echo echo-planar imaging (GE-EPI) and spin-echo EPI (SE-EPI) might indicate the relative cerebral blood volumes (rCBVs) of different tumor sizes. The techniques of GE-EPI and SE-EPI were compared for detecting low- versus high-grade gliomas. METHODS: Six patients with low-grade gliomas and 19 patients with high-grade gliomas underwent two perfusion-sensitive MR procedures, one produced by a GE- and the other by an SE-EPI technique. Maximum rCBV ratios normalized with rCBV of contralateral white matter were calculated for evaluation. P <.05 was considered statistically significant. RESULTS: Maximum rCBV ratios of high-grade gliomas obtained with the GE-EPI technique (mean, 5.0 +/- 2.9) were significantly higher than those obtained with the SE-EPI technique (mean, 2.9 +/- 2.3) (P =.02). Maximum rCBV ratios of low-grade gliomas obtained with the GE-EPI technique (mean, 1.2 +/- 0.7) were almost equal to those obtained with the SE-EPI technique (mean, 1.2 +/- 0.6), and there was no significant difference (P =.66). The difference in the maximum rCBV ratios between the low- and high-grade gliomas reached significance when obtained with the GE-EPI technique (P =.01). CONCLUSION: The GE-EPI technique seems more useful for detecting low- versus high-grade gliomas than the SE-EPI technique.  (+info)

The causes of dysphagia in carcinoma of the lung. (7/149)

Dysphagia occurs in only a small percentage of patients with lung cancer, but the frequency of this cancer means that large numbers are affected. Non-quantitative analysis of a large Scottish series of lung cancer cases indicates the following eight broad categories of dysphagia according to underlying mechanisms: mediastinal disease; cervical lymphadenopathy; brainstem lesions; gastrointestinal tract metastases; associated systemic disorders; second primaries; oropharyngeal and oesophageal infections; and radiation-induced oesophageal toxicity.  (+info)

Brainstem gliomas in adults: prognostic factors and classification. (8/149)

In contrast to childhood brainstem gliomas, adult brainstem gliomas are rare and poorly understood. The charts of 48 adults suffering from brainstem glioma were reviewed in order to determine prognostic factors, evaluate the effect of treatment and propose a classification of these tumours. Mean age at onset was 34 years (range 16-70 years). The main presenting symptoms were gait disturbance (61%), headache (44%), weakness of the limbs (42%) and diplopia (40%). Four patterns were identified on MRI, representing non-enhancing, diffusely infiltrative tumours (50%), contrast-enhancing localized masses (31%), isolated tectal tumours (8%) and other patterns (11%). Treatment consisted of partial resection (8%), radiotherapy (94%) and chemotherapy (56%). Overall median survival was 5.4 years. On univariate analysis, the following favourable prognostic factors were identified (P< 0.01): age of onset <40 years, duration of symptoms before diagnosis >3 months, Karnofski performance status >70, low-grade histology, absence of contrast enhancement and 'necrosis' on MRI. On multivariate analysis, the duration of symptoms, the appearance of 'necrosis' on MRI and the histological grade of the tumour remained significant and independent prognostic factors (P< 0.05). Eighty-five percent of the tumours could be classified into one of the following three groups on the basis of clinical, radiological and histological features. (i) Diffuse intrinsic low-grade gliomas (46%) usually occurred in young adults with a long clinical history before diagnosis and a diffusely enlarged brainstem on MRI that did not show contrast enhancement. These patients were improved by radiotherapy in 62% of cases and had a long survival time (median 7.3 years). Anaplastic transformation (appearance of contrast enhancement, 27%) and relentless growth without other changes (23%) were the main causes of death. (ii) Malignant gliomas (31%) occurred in elderly patients with a short clinical history. Contrast enhancement and necrosis were the rule on MRI. These tumours were highly resistant to treatment and the patients had a median survival time of 11.2 months. (iii) Focal tectal gliomas (8%) occurred in young patients and were often revealed by isolated hydrocephalus. The course was indolent and the projected median survival period exceeded 10 years. In conclusion, adult brainstem gliomas are different from the childhood forms and resemble supratentorial gliomas in adults. Low-grade tumours have a clinicoradiological pattern that is so characteristic that the need for a potentially harmful biopsy is debatable. The optimum timing of treatment for supratentorial low-grade tumours remains unclear. In high-grade gliomas, the prognosis remains extremely poor despite aggressive treatment with radiotherapy and chemotherapy.  (+info)

Brain stem neoplasms refer to tumors that originate in the brainstem, which is the lower part of the brain that connects to the spinal cord. These tumors can be benign or malignant and can arise from various types of cells within the brainstem, such as nerve cells, glial cells (which support and protect nerve cells), or cells that make up blood vessels.

Brain stem neoplasms are relatively rare, accounting for about 2% of all primary brain tumors. They can cause a variety of symptoms depending on their size and location, including headache, vomiting, double vision, difficulty swallowing, facial weakness, and problems with balance and coordination. Treatment options may include surgery, radiation therapy, and chemotherapy, depending on the type, location, and extent of the tumor.

The brainstem is the lower part of the brain that connects to the spinal cord. It consists of the midbrain, pons, and medulla oblongata. The brainstem controls many vital functions such as heart rate, breathing, and blood pressure. It also serves as a relay center for sensory and motor information between the cerebral cortex and the rest of the body. Additionally, several cranial nerves originate from the brainstem, including those that control eye movements, facial movements, and hearing.

According to the National Institutes of Health (NIH), stem cells are "initial cells" or "precursor cells" that have the ability to differentiate into many different cell types in the body. They can also divide without limit to replenish other cells for as long as the person or animal is still alive.

There are two main types of stem cells: embryonic stem cells, which come from human embryos, and adult stem cells, which are found in various tissues throughout the body. Embryonic stem cells have the ability to differentiate into all cell types in the body, while adult stem cells have more limited differentiation potential.

Stem cells play an essential role in the development and repair of various tissues and organs in the body. They are currently being studied for their potential use in the treatment of a wide range of diseases and conditions, including cancer, diabetes, heart disease, and neurological disorders. However, more research is needed to fully understand the properties and capabilities of these cells before they can be used safely and effectively in clinical settings.

Brain chemistry refers to the chemical processes that occur within the brain, particularly those involving neurotransmitters, neuromodulators, and neuropeptides. These chemicals are responsible for transmitting signals between neurons (nerve cells) in the brain, allowing for various cognitive, emotional, and physical functions.

Neurotransmitters are chemical messengers that transmit signals across the synapse (the tiny gap between two neurons). Examples of neurotransmitters include dopamine, serotonin, norepinephrine, GABA (gamma-aminobutyric acid), and glutamate. Each neurotransmitter has a specific role in brain function, such as regulating mood, motivation, attention, memory, and movement.

Neuromodulators are chemicals that modify the effects of neurotransmitters on neurons. They can enhance or inhibit the transmission of signals between neurons, thereby modulating brain activity. Examples of neuromodulators include acetylcholine, histamine, and substance P.

Neuropeptides are small protein-like molecules that act as neurotransmitters or neuromodulators. They play a role in various physiological functions, such as pain perception, stress response, and reward processing. Examples of neuropeptides include endorphins, enkephalins, and oxytocin.

Abnormalities in brain chemistry can lead to various neurological and psychiatric conditions, such as depression, anxiety disorders, schizophrenia, Parkinson's disease, and Alzheimer's disease. Understanding brain chemistry is crucial for developing effective treatments for these conditions.

A brain injury is defined as damage to the brain that occurs following an external force or trauma, such as a blow to the head, a fall, or a motor vehicle accident. Brain injuries can also result from internal conditions, such as lack of oxygen or a stroke. There are two main types of brain injuries: traumatic and acquired.

Traumatic brain injury (TBI) is caused by an external force that results in the brain moving within the skull or the skull being fractured. Mild TBIs may result in temporary symptoms such as headaches, confusion, and memory loss, while severe TBIs can cause long-term complications, including physical, cognitive, and emotional impairments.

Acquired brain injury (ABI) is any injury to the brain that occurs after birth and is not hereditary, congenital, or degenerative. ABIs are often caused by medical conditions such as strokes, tumors, anoxia (lack of oxygen), or infections.

Both TBIs and ABIs can range from mild to severe and may result in a variety of physical, cognitive, and emotional symptoms that can impact a person's ability to perform daily activities and function independently. Treatment for brain injuries typically involves a multidisciplinary approach, including medical management, rehabilitation, and supportive care.

Brain neoplasms, also known as brain tumors, are abnormal growths of cells within the brain. These growths can be benign (non-cancerous) or malignant (cancerous). Benign brain tumors typically grow slowly and do not spread to other parts of the body. However, they can still cause serious problems if they press on sensitive areas of the brain. Malignant brain tumors, on the other hand, are cancerous and can grow quickly, invading surrounding brain tissue and spreading to other parts of the brain or spinal cord.

Brain neoplasms can arise from various types of cells within the brain, including glial cells (which provide support and insulation for nerve cells), neurons (nerve cells that transmit signals in the brain), and meninges (the membranes that cover the brain and spinal cord). They can also result from the spread of cancer cells from other parts of the body, known as metastatic brain tumors.

Symptoms of brain neoplasms may vary depending on their size, location, and growth rate. Common symptoms include headaches, seizures, weakness or paralysis in the limbs, difficulty with balance and coordination, changes in speech or vision, confusion, memory loss, and changes in behavior or personality.

Treatment for brain neoplasms depends on several factors, including the type, size, location, and grade of the tumor, as well as the patient's age and overall health. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches. Regular follow-up care is essential to monitor for recurrence and manage any long-term effects of treatment.

Auditory brainstem evoked potentials (ABEPs or BAEPs) are medical tests that measure the electrical activity in the auditory pathway of the brain in response to sound stimulation. The test involves placing electrodes on the scalp and recording the tiny electrical signals generated by the nerve cells in the brainstem as they respond to clicks or tone bursts presented through earphones.

The resulting waveform is analyzed for latency (the time it takes for the signal to travel from the ear to the brain) and amplitude (the strength of the signal). Abnormalities in the waveform can indicate damage to the auditory nerve or brainstem, and are often used in the diagnosis of various neurological conditions such as multiple sclerosis, acoustic neuroma, and brainstem tumors.

The test is non-invasive, painless, and takes only a few minutes to perform. It provides valuable information about the functioning of the auditory pathway and can help guide treatment decisions for patients with hearing or balance disorders.

Brain mapping is a broad term that refers to the techniques used to understand the structure and function of the brain. It involves creating maps of the various cognitive, emotional, and behavioral processes in the brain by correlating these processes with physical locations or activities within the nervous system. Brain mapping can be accomplished through a variety of methods, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET) scans, electroencephalography (EEG), and others. These techniques allow researchers to observe which areas of the brain are active during different tasks or thoughts, helping to shed light on how the brain processes information and contributes to our experiences and behaviors. Brain mapping is an important area of research in neuroscience, with potential applications in the diagnosis and treatment of neurological and psychiatric disorders.

Brainstem infarctions refer to the damage or death of brain tissue in the brainstem due to lack of blood supply, resulting in a localized injury known as an infarction. The brainstem is a critical region that controls essential functions such as breathing, heart rate, and consciousness. Infarctions in this area can result in various symptoms depending on the location and extent of damage, which may include:

1. Hemiparesis or paralysis on one side of the body
2. Cranial nerve dysfunction, leading to double vision, slurred speech, or facial weakness
3. Difficulty swallowing or speaking
4. Unstable blood pressure and heart rate
5. Altered level of consciousness, ranging from confusion to coma
6. Abnormal muscle tone and reflexes
7. Respiratory disturbances, such as irregular breathing patterns or apnea (cessation of breathing)

Brainstem infarctions can be caused by various conditions, including atherosclerosis, embolism, vasospasm, or small vessel disease. Prompt diagnosis and treatment are crucial to minimize the risk of long-term disability or death.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

A plant stem is not typically defined in a medical context, but rather in the field of botany. However, I can certainly provide a general biological definition for you.

In plants, stems are organs that serve primarily as support structures, holding leaves, flowers, and fruits aloft where they can receive sunlight and exchange gases. They also act as conduits, transporting water, nutrients, and sugars made during photosynthesis between the roots and shoots of a plant.

The stem is usually composed of three main tissue systems: dermal, vascular, and ground. The dermal tissue system forms the outermost layer(s) of the stem, providing protection and sometimes participating in gas exchange. The vascular tissue system contains the xylem (which transports water and nutrients upward) and phloem (which transports sugars and other organic compounds downward). The ground tissue system, located between the dermal and vascular tissues, is responsible for food storage and support.

While not a direct medical definition, understanding the structure and function of plant stems can be relevant in fields such as nutrition, agriculture, and environmental science, which have implications for human health.

Hematopoietic stem cells (HSCs) are immature, self-renewing cells that give rise to all the mature blood and immune cells in the body. They are capable of both producing more hematopoietic stem cells (self-renewal) and differentiating into early progenitor cells that eventually develop into red blood cells, white blood cells, and platelets. HSCs are found in the bone marrow, umbilical cord blood, and peripheral blood. They have the ability to repair damaged tissues and offer significant therapeutic potential for treating various diseases, including hematological disorders, genetic diseases, and cancer.

Stem cell transplantation is a medical procedure where stem cells, which are immature and unspecialized cells with the ability to differentiate into various specialized cell types, are introduced into a patient. The main purpose of this procedure is to restore the function of damaged or destroyed tissues or organs, particularly in conditions that affect the blood and immune systems, such as leukemia, lymphoma, aplastic anemia, and inherited metabolic disorders.

There are two primary types of stem cell transplantation: autologous and allogeneic. In autologous transplantation, the patient's own stem cells are collected, stored, and then reinfused back into their body after high-dose chemotherapy or radiation therapy to destroy the diseased cells. In allogeneic transplantation, stem cells are obtained from a donor (related or unrelated) whose human leukocyte antigen (HLA) type closely matches that of the recipient.

The process involves several steps: first, the patient undergoes conditioning therapy to suppress their immune system and make space for the new stem cells. Then, the harvested stem cells are infused into the patient's bloodstream, where they migrate to the bone marrow and begin to differentiate and produce new blood cells. This procedure requires close monitoring and supportive care to manage potential complications such as infections, graft-versus-host disease, and organ damage.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.

Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.

Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.

There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.

Neoplastic stem cells, also known as cancer stem cells (CSCs), are a subpopulation of cells within a tumor that are capable of self-renewal and generating the heterogeneous lineages of cells that comprise the tumor. These cells are believed to be responsible for the initiation, maintenance, and progression of cancer, as well as its recurrence and resistance to therapy.

CSCs share some similarities with normal stem cells, such as their ability to divide asymmetrically and give rise to differentiated progeny. However, they also have distinct characteristics that distinguish them from their normal counterparts, including aberrant gene expression, altered signaling pathways, and increased resistance to apoptosis (programmed cell death).

The existence of CSCs has important implications for cancer diagnosis, treatment, and prevention. Targeting these cells specifically may be necessary to achieve durable remissions and prevent relapse, as they are thought to survive conventional therapies that target the bulk of the tumor. Further research is needed to better understand the biology of CSCs and develop effective strategies for their elimination.

Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.

Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.

Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.

Adult stem cells, also known as somatic stem cells, are undifferentiated cells found in specialized tissues or organs throughout the body of a developed organism. Unlike embryonic stem cells, which are derived from blastocysts and have the ability to differentiate into any cell type in the body (pluripotency), adult stem cells are typically more limited in their differentiation potential, meaning they can only give rise to specific types of cells within the tissue or organ where they reside.

Adult stem cells serve to maintain and repair tissues by replenishing dying or damaged cells. They can divide and self-renew over time, producing one daughter cell that remains a stem cell and another that differentiates into a mature, functional cell type. The most well-known adult stem cells are hematopoietic stem cells, which give rise to all types of blood cells, and mesenchymal stem cells, which can differentiate into various connective tissue cells such as bone, cartilage, fat, and muscle.

The potential therapeutic use of adult stem cells has been explored in various medical fields, including regenerative medicine and cancer therapy. However, their limited differentiation capacity and the challenges associated with isolating and expanding them in culture have hindered their widespread application. Recent advances in stem cell research, such as the development of techniques to reprogram adult cells into induced pluripotent stem cells (iPSCs), have opened new avenues for studying and harnessing the therapeutic potential of these cells.

Neurons, also known as nerve cells or neurocytes, are specialized cells that constitute the basic unit of the nervous system. They are responsible for receiving, processing, and transmitting information and signals within the body. Neurons have three main parts: the dendrites, the cell body (soma), and the axon. The dendrites receive signals from other neurons or sensory receptors, while the axon transmits these signals to other neurons, muscles, or glands. The junction between two neurons is called a synapse, where neurotransmitters are released to transmit the signal across the gap (synaptic cleft) to the next neuron. Neurons vary in size, shape, and structure depending on their function and location within the nervous system.

"Brain Stem Neoplasms" by people in this website by year, and whether "Brain Stem Neoplasms" was a major or minor topic of these ... "Brain Stem Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA ... Brain Stem Neoplasms*Brain Stem Neoplasms. *Brain Stem Neoplasm. *Neoplasm, Brain Stem ...
Kjaer M. Brain stem auditory and visual evoked potentials in multiple sclerosis. Acta Neurol Scand. 1980 Jul. 62(1):14-9. [QxMD ... Rowed et al used SEP to identify the somatosensory cortex in an effort to help remove intracranial neoplasms and spare eloquent ... Brainstem Auditory Evoked Potentials. The brainstem auditory evoked potential (BAEP), or brainstem auditory evoked response ( ... Effects of insulin and hypoglycemia on the auditory brain stem response in humans. J Neurophysiol. 1994 Aug. 72(2):678-83. [ ...
Brain Neoplasms / epidemiology* * Brain Neoplasms / surgery* * Brain Stem / abnormalities * Brain Stem / blood supply* ... Surgical strategies in treating brainstem cavernous malformations Neurosurgery. 2011 Mar;68(3):609-20; discussion 620-1. doi: ... Background: Optimal therapy of brainstem cavernous malformations (BSCMs) remains controversial because their biological ... was to perform complete CM resection and to preserve any associated venous malformation with minimal functional brainstem ...
Brain Tumours, Childhood. RNF213 and Brain Tumours. View Publications. 1. Brain Stem Glioma, Childhood. RNF213 and Brain Stem ... Tongue Neoplasms. *Tropomyosin. *Brain Stem Glioma, Childhood. *Translocation. *AURKA *Single Nucleotide Polymorphism ...
adult brain stem glioma. *Glioma. *Nervous System Neoplasms. *Central Nervous System Neoplasms ... Patients with clinical and radiographic diagnosis of brain stem glioma are. also eligible. - Evidence of tumor progression by ...
Other types of pathology in the brain stem segment are neoplasms (mostly glioma and metastases), vascular lesions (infarction, ... Brain stem segment. Pathology in the brain stem segment is most often due to demyelination by multiple sclerosis. ... This first part is called the brain stem segment.. From these nuclei, the trigeminal nerve courses anteriorly, to the ... Secondary neoplasms - involving the nerve, but not originating from it - are mostly based on perineural spread. The spread can ...
The neoplasm can also invade adjacent brainstem structures, including the cardiorespiratory centers of the fourth ventricular ... More recently, there has been emerging evidence that neural stem or progenitor cells may give rise to embryonal tumors of the ... Medulloblastoma stem cells. J Clin Oncol. 2008 Jun 10. 26(17):2821-7. [QxMD MEDLINE Link]. ... 4] Adult cases are unusual, accounting for less than 1% of brain tumors. Medulloblastoma is rare beyond the fifth decade. ...
Neoplasms involving the brain stem may result in cranial nerve deficits. Weakness and sensory abnormalities often are seen with ... and brain herniation. Primary brain tumors often are slow growing and the brain adapts to the slow increase in ICP. During this ... Increased CSF protein content and a normal to increased CSF white blood cell count are considered "typical" of a brain neoplasm ... Partial removal of a brain neoplasm may relieve signs of cerebral dysfunction, provide a histological diagnosis, and may make ...
Brain Stem 1 * Breast Neoplasms 1 Event type. * Symposium 34 * Congress 1 ... Amyotrophic Lateral Sclerosis, Neurodegenerative Diseases, Brain Stem, Spinal Cord, Respiratory Insufficiency, Paralysis ...
... the diagnosis and treatment of salivary gland neoplasms remain com... ... Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant ... Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. This ... These fibers leave the brainstem as the nervus intermedius to join with the facial nerve. They then leave the facial nerve with ...
Brain Neoplasms * Brain tumor-initiating cell (BTIC) * Cell Self Renewal * Disease Models, Animal ... Development of a Patient-Derived Xenograft Model Using Brain Tumor Stem Cell Systems to Study Cancer Journal Articles ... In the context of brain tumor initiating cells (BTICs), PDX models allow for characterization of tumor formation, growth, and ...
Brain stem glioma. E.1.2. System Organ Class 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps). ... Patient previously treated with irradiation on the brainstem for another neoplasm. *Patient with congenital galactose ... Non-brainstem diffuse midline gliomas, H3K27M mutant (NB-DMG), will be eligible for the trial after biopsy or surgery. *DIPG or ...
Brain tumours (glioblastoma, brain-stem gliomas, medulloblastoma, astrocytoma and ependymoma), brain metastases ... Carmustine is indicated n adults in the following malignant neoplasms as a single agent or in combination with other ... brain tumours, both those that develop directly in the brain and cancers that have spread from elsewhere in the body ( ... metastatic brain tumours);. • Hodgkins lymphoma and non-Hodgkins lymphomas, types of cancer that originate from white blood ...
Brain stem tumor • Skeletal musclular disorders • Myastenia gravis, Metabolic myopathy (T4 toxicosis, myxedema, steroid) • ... Muscular dystrophies • Local structural lesions • Neoplasms, extinsic compression (Thyroid, cervical spur), Surgery Common ... brain) Tumors of middle esophagus M1a Not applicable M1b Metastasis in nonregional lymph node or distant metastasis (eg: liver ...
The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current ... Gliomas are the most frequent type of brain tumor, classified from grade I to grade IV according to the rate of malignancy. ... in the treatment of infantile brain tumors, as a complementary approach to standard cancer therapy. ... Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. Todays dominant ...
Brain Neoplasms/pathology. MESH. Cell Line, Tumor. MESH. Cell Proliferation. MESH. Gene Expression Regulation, Neoplastic. MESH ... Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) ... Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) ...
... and apply her combined expertise in stem cells and signaling on the study of brain neoplasms and human stem and progenitor ... However, the discovery of continuous neuro-gliogenesis in the normal adult brain and the identification of brain tumor stem ... Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain FEBS ... In the healthy brain, neuroglia stem cells generate progenitors, which in turn give rise to differentiating cells that will ...
C04 - Neoplasms. Pontine Glioma. Brain Stem Neoplasms. C10 - Nervous System Diseases. Pontine Glioma. Brain Stem Neoplasms. ...
BRAIN STEM NEOPLASMS. NEOPLASIAS DO TRONCO CEREBRAL. NEURITIS DEL PLEXO BRAQUIAL. BRACHIAL PLEXUS NEURITIS. NEURITE DO PLEXO ... BRAIN HEMORRHAGE, TRAUMATIC. HEMORRAGIA ENCEFÁLICA TRAUMÁTICA. HEMORRAGIA TRAUMATICA DEL TRONCO CEREBRAL. BRAIN STEM HEMORRHAGE ... BRAIN STEM INFARCTIONS. INFARTOS DO TRONCO CEREBRAL. INFECCIONES BACTERIANAS DEL SISTEMA NERVIOSO CENTRAL. CENTRAL NERVOUS ... PICK DISEASE OF THE BRAIN. DOENÇA CEREBRAL DE PICK. ENFERMEDAD DEL CUERPO DE LEWY. LEWY BODY DISEASE. DOENÇA DOS CORPOS DE LEWY ...
C04 - Neoplasms. Pontine Glioma. Brain Stem Neoplasms. C10 - Nervous System Diseases. Pontine Glioma. Brain Stem Neoplasms. ...
BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFARTOS DO TRONCO CEREBRAL BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÃO CEREBRAL CRÔNICA BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA ... BRAIN HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL CEREBRO HEMORRAGIA ENCEFÁLICA TRAUMÁTICA BRAIN INFARCTION INFARTO DEL ... SEPTUM OF BRAIN SEPTUM DEL CEREBRO SEPTO DO CÉREBRO SEQUENCE ANALYSIS, PROTEIN ANALISIS DE SECUENCIA DE PROTEINA ANÁLISE DE ...
BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFARTOS DO TRONCO CEREBRAL BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÃO CEREBRAL CRÔNICA BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA ... BRAIN HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL CEREBRO HEMORRAGIA ENCEFÁLICA TRAUMÁTICA BRAIN INFARCTION INFARTO DEL ... SEPTUM OF BRAIN SEPTUM DEL CEREBRO SEPTO DO CÉREBRO SEQUENCE ANALYSIS, PROTEIN ANALISIS DE SECUENCIA DE PROTEINA ANÁLISE DE ...
C04 - Neoplasms. Pontine Glioma. Brain Stem Neoplasms. C10 - Nervous System Diseases. Pontine Glioma. Brain Stem Neoplasms. ...
BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO CEREBRAL NEUREGULINA-1 NEUREGULIN-1 NEURREGULINA-1 ... BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL TRONCO CEREBRAL HEMORRAGIA DOS GÂNGLIOS DA BASE BASAL GANGLIA ... BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFECÇÕES BACTERIANAS DO SISTEMA NERVOSO CENTRAL CENTRAL NERVOUS SYSTEM ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÕES DAS ARTÉRIAS CARÓTIDAS CAROTID ARTERY INJURIES TRAUMATISMOS DE LA ...
BRAIN STEM NEOPLASMS. NEOPLASIAS DO TRONCO CEREBRAL. NEURITIS DEL PLEXO BRAQUIAL. BRACHIAL PLEXUS NEURITIS. NEURITE DO PLEXO ... BRAIN HEMORRHAGE, TRAUMATIC. HEMORRAGIA ENCEFÁLICA TRAUMÁTICA. HEMORRAGIA TRAUMATICA DEL TRONCO CEREBRAL. BRAIN STEM HEMORRHAGE ... BRAIN STEM INFARCTIONS. INFARTOS DO TRONCO CEREBRAL. INFECCIONES BACTERIANAS DEL SISTEMA NERVIOSO CENTRAL. CENTRAL NERVOUS ... PICK DISEASE OF THE BRAIN. DOENÇA CEREBRAL DE PICK. ENFERMEDAD DEL CUERPO DE LEWY. LEWY BODY DISEASE. DOENÇA DOS CORPOS DE LEWY ...
BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFARTOS DO TRONCO CEREBRAL BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÃO CEREBRAL CRÔNICA BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA ... BRAIN HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL CEREBRO HEMORRAGIA ENCEFÁLICA TRAUMÁTICA BRAIN INFARCTION INFARTO DEL ... SEPTUM OF BRAIN SEPTUM DEL CEREBRO SEPTO DO CÉREBRO SEQUENCE ANALYSIS, PROTEIN ANALISIS DE SECUENCIA DE PROTEINA ANÁLISE DE ...
BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO CEREBRAL NEUREGULINA-1 NEUREGULIN-1 NEURREGULINA-1 ... BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL TRONCO CEREBRAL HEMORRAGIA DOS GÂNGLIOS DA BASE BASAL GANGLIA ... BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFECÇÕES BACTERIANAS DO SISTEMA NERVOSO CENTRAL CENTRAL NERVOUS SYSTEM ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÕES DAS ARTÉRIAS CARÓTIDAS CAROTID ARTERY INJURIES TRAUMATISMOS DE LA ...
BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFARTOS DO TRONCO CEREBRAL BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÃO CEREBRAL CRÔNICA BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA ... BRAIN HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL CEREBRO HEMORRAGIA ENCEFÁLICA TRAUMÁTICA BRAIN INFARCTION INFARTO DEL ... SEPTUM OF BRAIN SEPTUM DEL CEREBRO SEPTO DO CÉREBRO SEQUENCE ANALYSIS, PROTEIN ANALISIS DE SECUENCIA DE PROTEINA ANÁLISE DE ...
BRAIN STEM INFARCTIONS INFARTOS DEL TRONCO CEREBRAL INFARTOS DO TRONCO CEREBRAL BRAIN STEM NEOPLASMS NEOPLASMAS DEL TRONCO ... BRAIN INJURY, CHRONIC TRAUMATISMO CEREBRAL CRÔNICO LESÃO CEREBRAL CRÔNICA BRAIN STEM HEMORRHAGE, TRAUMATIC HEMORRAGIA ... BRAIN HEMORRHAGE, TRAUMATIC HEMORRAGIA TRAUMATICA DEL CEREBRO HEMORRAGIA ENCEFÁLICA TRAUMÁTICA BRAIN INFARCTION INFARTO DEL ... SEPTUM OF BRAIN SEPTUM DEL CEREBRO SEPTO DO CÉREBRO SEQUENCE ANALYSIS, PROTEIN ANALISIS DE SECUENCIA DE PROTEINA ANÁLISE DE ...
1994, Adult, Audiometry, Auditory, Brain Stem, Cranial Nerve Neoplasms/diagnosis/*pathology/surgery, Deafness/diagnosis/ ... Adult; Humans; Male; Magnetic Resonance Imaging; Functional Laterality; Evoked Potentials; Audiometry; Cranial Nerve Neoplasms/ ...

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