Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.
A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
The pathologic narrowing of the orifice of the TRICUSPID VALVE. This hinders the emptying of RIGHT ATRIUM leading to elevated right atrial pressure and systemic venous congestion. Tricuspid valve stenosis is almost always due to RHEUMATIC FEVER.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.
Hydroxyindoleacetic acid (5HIAA) is a major metabolite of serotonin, a neurotransmitter, formed by the action of monoamine oxidase and aldehyde dehydrogenase, and its measurement in urine is often used as a biomarker for serotonin synthesis in clinical and research settings.
A valve situated at the entrance to the pulmonary trunk from the right ventricle.
Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1, mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2, chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The hollow, muscular organ that maintains the circulation of the blood.

Carcinoid heart disease from ovarian primary presenting with acute pericarditis and biventricular failure. (1/47)

A case is described of a 54 year old woman who had acute pericarditis with large exudative effusion accompanied by severe right and left ventricular failure. The patient was finally diagnosed with carcinoid heart disease from an ovarian carcinoid teratoma. She was treated with octreotide--a somatostatin analogue--followed by radical surgical resection of the neoplasm. At one year follow up only mild carcinoid tricuspid regurgitation remained. Only 16 cases of carcinoid heart disease from an ovarian primary have been described in literature. Moreover clinically manifest acute, nonmetastatic pericarditis and left heart failure are not considered as possible presentations of carcinoid heart disease, whatever the origin. In a recent series a small pericardial effusion was considered an infrequent and unexpected echocardiographic finding in carcinoid heart patients. One case of "carcinoid pericarditis" has previously been described as a consequence of pericardial metastasis. Left sided heart involvement is usually caused by bronchial carcinoids or patency of foramen ovale; both were excluded in the case presented.  (+info)

Balloon pulmonary valvuloplasty in carcinoid syndrome. (2/47)

Half of all patients with carcinoid syndrome develop cardiac involvement. Patients who have cardiac involvement have a significantly worse prognosis than those without, and death can occur directly as a result of cardiac involvement. A case of carcinoid syndrome in a 38 year old woman with lesions in the liver, who presented with right sided valvar abnormalities, a dilated right ventricle, and right ventricular pressure overload, is presented. In order to palliate the patient's symptoms and to decrease right sided pressures before major abdominal surgery, balloon pulmonary valvuloplasty was performed at the time of cardiac catheterisation. This resulted in a reduction in the pulmonary gradient and right ventricular pressure. Following the procedure, the patient's symptoms were completely relieved. She went on to laparotomy where the lesions in the liver were excised without complication.  (+info)

Tricuspid and pulmonary valve involvement in carcinoid disease. (3/47)

We report the case of a 62-year-old woman in whom carcinoid disease had been diagnosed 6 years earlier. She subsequently developed tricuspid and pulmonary valve disease. Both valves were incompetent and mildly stenotic. The tricuspid valve required surgery; the pulmonary vaive was explored but not treated. Valve surgery in patients with carcinoid disease is discussed in light of the prognosis of these patients, the timing of valvular lesion presentation, and the choice of prosthesis. The justification for multiple-valve procedures in such cases is also considered.  (+info)

Perianaesthetic risks and outcomes of abdominal surgery for metastatic carcinoid tumours. (4/47)

Patients with metastatic carcinoid tumours often undergo surgical procedures to reduce the tumour burden and associated debilitating symptoms. These procedures and anaesthesia can precipitate a life-threatening carcinoid crisis. To assess perioperative outcomes, we studied retrospectively the medical records of adult patients from 1983 to 1996 who underwent abdominal surgery for metastatic carcinoid tumours. Preoperative risk factors, intraoperative complications and complications occurring in the 30 days after surgery were recorded. Perioperative complications or death occurred in 15 of 119 patients (12.6%, exact confidence interval 7.2-19.9). None of the 45 patients who received octreotide intraoperatively experienced intraoperative complications compared with eight of the 73 patients (11.0%) who did not receive octreotide (P=0.023). The presence of carcinoid heart disease and high urinary output of 5-hydroxyindoleacetic acid preoperatively were statistically significant risk factors for perioperative complications.  (+info)

Surgical management of left-sided carcinoid heart disease. (5/47)

BACKGROUND: Carcinoid involvement of left-sided heart valves has been reported in patients with a patent foramen ovale, carcinoid tumor of the lung, and active carcinoid syndrome with high levels of serotonin. The present study details the clinical features and surgical management of patients with carcinoid heart disease affecting both left- and right-sided valves. METHODS AND RESULTS: Eleven patients (7 men, 4 women) with symptomatic carcinoid heart disease underwent surgery for left- and right-sided valve disease between 1989 and 1999. Mean age was 57+/-9 years, and median preoperative NYHA class was 3. All patients had metastatic carcinoid tumors and were on somatostatin analog. Of 11 patients, 5 (45%) had a patent foramen ovale; 1 of these also had a primary lung carcinoid tumor. Surgery included tricuspid valve replacement in all patients, pulmonary valve replacement in 3 and valvectomy in 7, mitral valve replacement in 6 and repair in 1, aortic valve replacement in 4 and repair in 2, CABG in 2, and patent foramen ovale closure in 5. One myocardial metastatic carcinoid tumor was removed. There were 2 perioperative deaths. At a mean follow-up of 41 months, 4 additional patients were dead. All but 1 surgical survivor initially improved >/=1 functional class. No patient required reoperation. CONCLUSIONS: Carcinoid heart disease may affect left- and right-sided valves and occurred without intracardiac shunting in 55% of this surgical series. Despite metastatic disease that limits longevity, operative survivors had improvement in functional capacity. Cardiac surgery should be considered for select patients with carcinoid heart disease affecting left- and right-sided valves.  (+info)

Carcinoid heart disease: successful tricuspid valve replacement. (6/47)

A woman aged 46 was found to have severe tricuspid valve disease 14 years after the diagnosis of a malignant carcinoid tumour of the ileum and 33 years after the onset of symptoms attributable to the disease. Increasing ascites requiring repeated paracentesis had not responded to chemotherapy including infusion of 5-fluorouracil and vincristine into the coeliac artery. The tricuspid valve was replaced by a Bjork-Shiley prosthesis. After operation there was no recurrence of ascites or oedema. She remains well one year and 11 months later. It is suggested that valve replacement surgery should be considered more often in patients with carcinoid heart disease. Hepatomegaly and ascites sould not be attributed too readily to advancing malignant disease without careful consideration of the role of right-sided valvar lesions in the production of these signs.  (+info)

Cardiovascular abnormalities in patients with a carcinoid syndrome. (7/47)

BACKGROUND: Heart failure is an important reason for morbidity and mortality in patients with carcinoid. Carcinoid heart disease is caused by increased levels of circulating serotonin. Because carcinoids also produce catecholamines, we evaluated cardiovascular manifestations of autonomic dysfunction in patients with a carcinoid syndrome. METHODS: Twenty patients with a midgut carcinoid, who had a carcinoid syndrome with a median duration of 72 months, and markedly elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion were studied. RESULTS: Ten patients had no symptoms of heart failure, i.e. New York Heart Association (NYHA) functional class I, 6 had class II, and 4 class III heart failure. Transthoracic echocardiography (TTE) showed right-sided valvular abnormalities in 13 of 19 evaluable patients (mild n=8, severe n=5). Fourteen of the 20 patients (70%) had an elevated concentration of plasma N-terminal atrial natriuretic peptide (N-ANP), which correlated with NYHA class, TTE abnormalities, and increased urinary metanephrine excretion. Heart rate variability (HRV) parameters, in particular those associated with increased sympathetic activity (low frequency power, p=0.002 versus healthy individuals), were impaired but were independent of NYHA class and TTE findings and correlated with urinary metanephrine excretion (r=-0.49, p<0.05). CONCLUSION: In these 20 carcinoid patients with substantial secretory activity of the tumour, overt cardiac morphological changes were present in a minority of patients. However, N-ANP values and HRV profile were markedly abnormal, and related to enhanced urinary excretion of catecholamine and metabolites, suggesting autonomic derangement. These abnormalities possibly herald the development of more severe cardiac dysfunction and may be indicative of the need for preventive drug treatment.  (+info)

Echocardiographic diagnosis in carcinoid heart disease. (8/47)

In this case report the typical echocardiographic features of carcinoid heart disease are presented. Newer treatments such as the use of a somatostatin analogue, interferon and hepatic de-arterialisation have improved the prognosis in patients with carcinoid syndrome. Nevertheless this syndrome portends a poor prognosis in patients with cardiac involvement. Cardiac lesions are mainly located in the right side of the heart. Regurgitation and stenosis of the tricuspid and pulmonary valve, leading to right heart failure, are the most common cardiac manifestations of the disease. Elevated levels of serotonin are probably responsible for the development of these cardiac lesions. Despite treatment resulting in significant reductions of urinary levels of 5-HIAA, regression of the cardiac manifestations in carcinoid syndrome has not been observed. Two-dimensional and Doppler echocardiography are the main tools to establish the diagnosis and severity of carcinoid heart disease. Cardiac surgery for carcinoid heart disease might improve symptoms and longevity, but the scarce data report on early mortality of over 35%.  (+info)

Carcinoid heart disease is a rare complication that occurs in some people with carcinoid tumors, which are slow-growing tumors that typically originate in the digestive tract. These tumors can release hormones and other substances into the bloodstream, which can cause various symptoms. In carcinoid heart disease, these substances cause fibrous plaques to form on the heart valves, leading to thickening and stiffening of the valve leaflets. This can result in leakage or obstruction of the heart valves, causing symptoms such as shortness of breath, fatigue, and fluid retention. Carcinoid heart disease is most commonly affects the tricuspid and pulmonary valves, which are located on the right side of the heart. If left untreated, carcinoid heart disease can lead to serious complications, including heart failure. Treatment typically involves a combination of medications to manage symptoms and control the growth of the tumor, as well as surgery to repair or replace damaged heart valves.

Malignant carcinoid syndrome is a complex of symptoms that occur in some people with malignant tumors (carcinoids) that secrete large amounts of hormone-like substances, particularly serotonin. These symptoms can include flushing of the face and upper body, diarrhea, rapid heartbeat, difficulty breathing, and abdominal pain and distention. In addition, these individuals may have chronic inflammation of the heart valves (endocarditis) leading to heart failure. It is important to note that not all people with carcinoid tumors will develop malignant carcinoid syndrome, but those who do require specific treatment for their symptoms and hormonal imbalances.

A carcinoid tumor is a type of slow-growing neuroendocrine tumor that usually originates in the digestive tract, particularly in the small intestine. These tumors can also arise in other areas such as the lungs, appendix, and rarely in other organs. Carcinoid tumors develop from cells of the diffuse endocrine system (also known as the neuroendocrine system) that are capable of producing hormones or biologically active amines.

Carcinoid tumors can produce and release various hormones and bioactive substances, such as serotonin, histamine, bradykinins, prostaglandins, and tachykinins, which can lead to a variety of symptoms. The most common syndrome associated with carcinoid tumors is the carcinoid syndrome, characterized by flushing, diarrhea, abdominal cramping, and wheezing or difficulty breathing.

Carcinoid tumors are typically classified as functional or nonfunctional based on whether they produce and secrete hormones that cause symptoms. Functional carcinoid tumors account for approximately 30% of cases and can lead to the development of carcinoid syndrome, while nonfunctional tumors do not produce significant amounts of hormones and are often asymptomatic until they grow large enough to cause local or distant complications.

Treatment options for carcinoid tumors depend on the location, size, and extent of the tumor, as well as whether it is functional or nonfunctional. Treatment may include surgery, medications (such as somatostatin analogs, chemotherapy, or targeted therapies), and radiation therapy. Regular follow-up with imaging studies and biochemical tests is essential to monitor for recurrence and assess treatment response.

Tricuspid valve stenosis is a cardiac condition characterized by the narrowing or stiffening of the tricuspid valve, which is located between the right atrium and right ventricle in the heart. This narrowing or stiffening restricts the normal flow of blood from the right atrium into the right ventricle, causing increased pressure in the right atrium and reduced blood flow to the lungs.

The tricuspid valve typically has three leaflets or cusps that open and close to regulate the flow of blood between the right atrium and right ventricle. In tricuspid valve stenosis, these leaflets become thickened, calcified, or fused together, leading to a reduced opening size and impaired function.

The most common causes of tricuspid valve stenosis include rheumatic heart disease, congenital heart defects, carcinoid syndrome, and infective endocarditis. Symptoms may include fatigue, shortness of breath, swelling in the legs and abdomen, and irregular heartbeats. Treatment options depend on the severity of the condition and underlying causes but may involve medications, surgical repair or replacement of the valve, or catheter-based procedures.

Heart valves are specialized structures in the heart that ensure unidirectional flow of blood through its chambers during the cardiac cycle. There are four heart valves: the tricuspid valve and the mitral (bicuspid) valve, located between the atria and ventricles, and the pulmonic (pulmonary) valve and aortic valve, located between the ventricles and the major blood vessels leaving the heart.

The heart valves are composed of thin flaps of tissue called leaflets or cusps, which are supported by a fibrous ring. The aortic and pulmonic valves have three cusps each, while the tricuspid and mitral valves have three and two cusps, respectively.

The heart valves open and close in response to pressure differences across them, allowing blood to flow forward into the ventricles during diastole (filling phase) and preventing backflow of blood into the atria during systole (contraction phase). A properly functioning heart valve ensures efficient pumping of blood by the heart and maintains normal blood circulation throughout the body.

Tricuspid valve insufficiency, also known as tricuspid regurgitation, is a cardiac condition in which the tricuspid valve located between the right atrium and right ventricle of the heart does not close properly, allowing blood to flow back into the right atrium during contraction of the right ventricle. This results in a portion of the blood being pumped inefficiently, which can lead to volume overload of the right side of the heart and potentially result in symptoms such as fatigue, weakness, shortness of breath, and fluid retention. The condition can be congenital or acquired, with common causes including dilated cardiomyopathy, infective endocarditis, rheumatic heart disease, and trauma.

Heart valve diseases are a group of conditions that affect the function of one or more of the heart's four valves (tricuspid, pulmonic, mitral, and aortic). These valves are responsible for controlling the direction and flow of blood through the heart. Heart valve diseases can cause the valves to become narrowed (stenosis), leaky (regurgitation or insufficiency), or improperly closed (prolapse), leading to disrupted blood flow within the heart and potentially causing symptoms such as shortness of breath, fatigue, chest pain, and irregular heart rhythms. The causes of heart valve diseases can include congenital defects, age-related degenerative changes, infections, rheumatic heart disease, and high blood pressure. Treatment options may include medications, surgical repair or replacement of the affected valve(s), or transcatheter procedures.

The tricuspid valve is the heart valve that separates the right atrium and the right ventricle in the human heart. It is called "tricuspid" because it has three leaflets or cusps, which are also referred to as flaps or segments. These cusps are named anterior, posterior, and septal. The tricuspid valve's function is to prevent the backflow of blood from the ventricle into the atrium during systole, ensuring unidirectional flow of blood through the heart.

Hydroxyindoleacetic acid (5HIAA) is a major metabolite of the neurotransmitter serotonin, formed in the body through the enzymatic degradation of serotonin by monoamine oxidase and aldehyde dehydrogenase. 5HIAA is primarily excreted in the urine and its measurement can be used as a biomarker for serotonin synthesis and metabolism in the body.

Increased levels of 5HIAA in the cerebrospinal fluid or urine may indicate conditions associated with excessive serotonin production, such as carcinoid syndrome, while decreased levels may be seen in certain neurodegenerative disorders, such as Parkinson's disease. Therefore, measuring 5HIAA levels can have diagnostic and therapeutic implications for these conditions.

The pulmonary valve, also known as the pulmonic valve, is a semilunar valve located at the exit of the right ventricle of the heart and the beginning of the pulmonary artery. It has three cusps or leaflets that prevent the backflow of blood from the pulmonary artery into the right ventricle during ventricular diastole, ensuring unidirectional flow of blood towards the lungs for oxygenation.

A bioprosthesis is a type of medical implant that is made from biological materials, such as heart valves or tendons taken from animals (xenografts) or humans (allografts). These materials are processed and sterilized to be used in surgical procedures to replace damaged or diseased tissues in the body.

Bioprosthetic implants are often used in cardiac surgery, such as heart valve replacement, because they are less likely to cause an immune response than synthetic materials. However, they may have a limited lifespan due to calcification and degeneration of the biological tissue over time. Therefore, bioprosthetic implants may need to be replaced after several years.

Bioprostheses can also be used in other types of surgical procedures, such as ligament or tendon repair, where natural tissue is needed to restore function and mobility. These prostheses are designed to mimic the properties of native tissues and provide a more physiological solution than synthetic materials.

Echocardiography is a medical procedure that uses sound waves to produce detailed images of the heart's structure, function, and motion. It is a non-invasive test that can help diagnose various heart conditions, such as valve problems, heart muscle damage, blood clots, and congenital heart defects.

During an echocardiogram, a transducer (a device that sends and receives sound waves) is placed on the chest or passed through the esophagus to obtain images of the heart. The sound waves produced by the transducer bounce off the heart structures and return to the transducer, which then converts them into electrical signals that are processed to create images of the heart.

There are several types of echocardiograms, including:

* Transthoracic echocardiography (TTE): This is the most common type of echocardiogram and involves placing the transducer on the chest.
* Transesophageal echocardiography (TEE): This type of echocardiogram involves passing a specialized transducer through the esophagus to obtain images of the heart from a closer proximity.
* Stress echocardiography: This type of echocardiogram is performed during exercise or medication-induced stress to assess how the heart functions under stress.
* Doppler echocardiography: This type of echocardiogram uses sound waves to measure blood flow and velocity in the heart and blood vessels.

Echocardiography is a valuable tool for diagnosing and managing various heart conditions, as it provides detailed information about the structure and function of the heart. It is generally safe, non-invasive, and painless, making it a popular choice for doctors and patients alike.

In medical terms, the heart is a muscular organ located in the thoracic cavity that functions as a pump to circulate blood throughout the body. It's responsible for delivering oxygen and nutrients to the tissues and removing carbon dioxide and other wastes. The human heart is divided into four chambers: two atria on the top and two ventricles on the bottom. The right side of the heart receives deoxygenated blood from the body and pumps it to the lungs, while the left side receives oxygenated blood from the lungs and pumps it out to the rest of the body. The heart's rhythmic contractions and relaxations are regulated by a complex electrical conduction system.

Symptoms of carcinoid crisis include flushing, hypotension, arrhythmia and bronchospasm. Carcinoid heart disease is the result ... "Carcinoid Heart Disease: Review of Current Knowledge". Texas Heart Institute Journal. 46 (1): 21-27. doi:10.14503/THIJ-17-6562 ... an echocardiogram is recommended for evaluation of carcinoid heart disease. Other conditions similar to the carcinoid syndrome ... Heart Disease: About 60-70% of the those affected by carcinoid syndrome develop cardiac complications. This mainly affects the ...
Fox DJ, Khattar RS (2004). "Carcinoid heart disease: presentation, diagnosis, and management". Heart. 90 (10): 1224-8. doi: ... Carcinoid tumors are also found in the lungs. Metastasis of carcinoid can lead to carcinoid syndrome. This is due to the over- ... and right-sided cardiac valve disease. It is estimated that less than 6% of carcinoid patients will develop carcinoid syndrome ... so-called coincidental carcinoids), all carcinoids are considered to have malignant potential. About 10% of carcinoids secrete ...
2004 Jun;32(3):170-5. Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Pellikka PA, Tajik AJ, ... Chapter 10: Heart. "Rheumatic heart disease". Heart & Stroke. Heart and Stroke Foundation of Canada. 2022. "Rheumatic heart ... Pulmonary and tricuspid valve diseases are right heart diseases. Pulmonary valve diseases are the least common heart valve ... Valvular heart disease is any cardiovascular disease process involving one or more of the four valves of the heart (the aortic ...
"Improving outcome of valve replacement for carcinoid heart disease". The Journal of Thoracic and Cardiovascular Surgery. 158 (1 ... "Valvular heart disease and the use of dopamine agonists for Parkinson's disease". The New England Journal of Medicine. 356 (1 ... Certain diseases such as neuroendocrine tumor of the small intestine (also known by the obsolete term carcinoid), which ... December 2007). "Heart valve regurgitation, pergolide use, and parkinson disease: an observational study and meta-analysis". ...
Carcinoid heart disease was identified in 1952, and carcinoid fibrosis in 1961. Neuroendocrine tumors were sometimes called ... "Carcinoid Tumors and the Carcinoid Syndrome: What's New in the Therapeutic Pipeline". Carcinoid Symposium 2002. The Carcinoid ... In malignant carcinoid tumors with carcinoid syndrome, the median survival has improved from two years to more than eight years ... There may be associated atypical carcinoid syndrome, acromegaly, Cushing disease, other endocrine disorders, telangiectasia, or ...
August 2007). "Percutaneous closure of a patent foramen ovale in left-sided carcinoid heart disease". Nat Clin Pract Cardiovasc ... Congenital Heart Disease in Comprehensive Pediatric Hospital Medicine. Zaoutis LB, Chiang VW. 2007. ISBN 0-323-03004-1 Singh, ... Barry A. Love is an American cardiologist specializing in pediatric and congenital heart problems. Love is director of the ... Katie Charles (January 20, 2011). "Congenital heart problems can be spotted even before birth". New York Daily News. Retrieved ...
"Percutaneous closure of a patent foramen ovale in left-sided carcinoid heart disease". Nat Clin Pract Cardiovasc Med. 4 (8): ... Clinical investigation topics include congestive heart failure, Raynaud's disease and mitral valve disease. Extramural honors ... Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and ... December 2008). "ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American ...
About Pulmonary valve disease , Patient". Patient. Retrieved 2015-11-18. Choices, NHS. "Congenital heart disease - Types - NHS ... it may also be due to a malignant carcinoid tumor. Both stenosis of the pulmonary artery and pulmonary valve stenosis are forms ... Valvular Heart Disease. Springer Science & Business Media. p. 266. ISBN 9781597454117. "Pulmonary Valve Disease. ... "Congenital heart disease - Treatment - NHS Choices". www.nhs.uk. Retrieved 2015-11-18. "Balloon dilatation of pulmonary valve ...
"Congenital heart defects and fetal alcohol spectrum disorders". Congenital Heart Disease. 2 (4): 250-255. doi:10.1111/j.1747- ... and leftsided carcinoid heartdisease (mitral valve). No cause is established for a foramen ovale to remain open instead of ... "Patent Foramen Ovale". Texas Heart Institute Heart Information Center. "Patent Foramen Ovale (PFO)". www.heart.org. Furlan AJ, ... ASDs make up 30 to 40% of all congenital heart diseases that are seen in adults. The ostium secundum atrial septal defect ...
... malignant carcinoid syndrome MeSH C04.557.465.625.650.200.500.205 - carcinoid heart disease MeSH C04.557.465.625.650.240 - ... malignant carcinoid syndrome MeSH C04.557.470.200.025.200.500.205 - carcinoid heart disease MeSH C04.557.470.200.025.215 - ... malignant carcinoid syndrome MeSH C04.557.580.625.650.200.500.205 - carcinoid heart disease MeSH C04.557.580.625.650.240 - ... hodgkin disease MeSH C04.557.386.390 - immunoproliferative small intestinal disease MeSH C04.557.386.480 - lymphoma, non- ...
... myopathies Pseudoxanthoma elasticum Sarcomeric protein disorders Werner's syndrome Endomyocardial Carcinoid heart disease ... "Worsening of congestive heart failure in amyloid heart disease treated by calcium channel-blocking agents". American Journal of ... Primary hyperoxaluria Storage diseases Fabry disease Gaucher disease Hereditary hemochromatosis Glycogen storage disease ... "restrictive cardiomyopathy" at Dorland's Medical Dictionary Pathophysiology of heart disease : a collaborative project of ...
Pulmonary hypertension Infective endocarditis Rheumatic heart disease Connective tissue disease Carcinoid syndrome Congenital ... "Pulmonary regurgitation in congenital heart disease". Heart. 93 (7): 880-889. doi:10.1136/hrt.2005.075234. ISSN 1355-6037. PMC ... "Pulmonary Valve Disease. About Pulmonary valve disease , Patient". Patient. Retrieved 2015-08-29. McGlothlin, edited by Michael ... Valvular heart disease, Vascular diseases, Medical signs). ... "pulmonary Valve disease". Patient.info. EMIS Group. Retrieved ...
... thromboembolism Myocardial disease Right ventricular ischemia and infraction Left to right shunt Carcinoid heart disease In ... is a type of valvular heart disease in which the tricuspid valve of the heart, located between the right atrium and right ... Chronic rheumatic heart diseases, Valvular heart disease). ... Moss and Adams heart disease in infants, children, and ... However, the murmur may be inaudible due to the relatively low pressures in the right side of the heart. A third heart sound ...
... liver disease. Selim Sesler, 57, Turkish clarinet player. Mary Stewart, 97, British novelist (Merlin series), heart failure. ... Don Meyer, 69, American basketball coach (Hamline Pipers, Lipscomb Bisons, Northern State Wolves), carcinoid cancer. Chukwuedu ... heart disease. John Vasconcellos, 82, American politician, member of the California State Assembly (1966-1996) and Senate (1996 ... Henning Carlsen, 86, Danish Bodil Award-winning film director (Hunger, People Meet and Sweet Music Fills the Heart). Robert ...
"Siegfried oberndorfer and the evolution of carcinoid disease". Archives of Surgery. 142 (2): 187-197. doi:10.1001/archsurg. ... diarrhea and in some cases fibrosis of the heart valves.[citation needed] There are often several small and highly fibrotic ... The disease was named by Siegfried Oberndorfer, a German pathologist, in 1907. A large fraction of cases are diagnosed after ... A small intestine neuroendocrine tumor is a carcinoid in the distal small intestine or the proximal large intestine. It is a ...
Males are more likely to develop a horseshoe kidney with a preponderance of 2:1. Certain genetic diseases can predispose ... Kidney cancer - increased frequency of certain renal cancers such as transitional cell tumors, Wilms tumors, and carcinoid ... Heart abnormalities - ventricular septal defect Neurological abnormalities - encephalocoele, myelomeningocoele, spina bifida ... adult polycystic kidney disease, and more than two kidneys. Genetic abnormalities - Turner syndrome, Down syndrome, Patau ...
... is a valvular heart disease that narrows the opening of the heart's tricuspid valve. It is a ... Rheumatic disease Carcinoid syndrome Pacemaker leads (complication) A mild diastolic murmur can be heard during auscultation ... Valvular heart disease, Chronic rheumatic heart diseases). ... Catheter Device Therapies for Heart Failure". Heart Failure in ... However, severe stenosis, or damage to other valves in the heart, may require surgical repair or replacement. The treatment is ...
... hypertension Elevated cholesterol Tobacco CARCinoid: Cutaneous flushing Asthmatic wheezing Right sided valvular heart lesions ... Acute blood loss Bone marrow failure Chronic disease Destruction (hemolysis) ANEMIA: Anemia of chronic disease No folate or B12 ...
The drug is in decreasing use, as it was reported in 2003 to be associated with a form of heart disease called cardiac fibrosis ... including serotonin itself when elevated in the blood in carcinoid syndrome. Pergolide can rarely cause Raynaud's phenomenon. ... Parkinson's disease is associated with reduced dopamine activity in the substantia nigra of the brain. Pergolide acts on many ... for human use after several published studies revealed a link between the drug and increased rates of valvular heart disease. ...
ISBN 978-0-7817-7153-5. Chapter 1: Diseases of the Cardiovascular system > Section: Valvular Heart Disease Greenberg BH, Massie ... Other causes are mitral degenerative disease, severe calcification (elderly), congenital deformities, malignant carcinoid ... The most common causes are myxomatous degeneration (Barlow disease), ischemic heart disease, dilated cardiomyopathy, rheumatic ... "2017 ESC/EACTS Guidelines for the management of valvular heart disease". European Heart Journal. 38 (36): 2739-2791. doi: ...
... caffeine consumption carbon monoxide poisoning carcinoid tumor chronic obstructive pulmonary disease (COPD), especially ... abrupt cessation of physical exertion (resulting in heart output in excess of current muscular need for blood flow) abdominal ... Flushing is also a cardinal symptom of carcinoid syndrome-the syndrome that results from hormones (often serotonin or histamine ...
As the disease progresses, a mixed pattern of obstruction and restriction may develop. In general the obstructive lung disease ... Upon surgical resection, histologically the nodules are found to be typical carcinoids or carcinoid tumorlets depending on size ... Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon, France: IARC Press. Wirstschafter, E; Walts, A; ... The morbidity associated with DIPNECH is due to the associated obstructive lung disease. The lung disease tends to be slowly ...
... heart and lung disease. Gloria Jean, 92, American singer and actress (The Under-Pup, Pardon My Rhythm, Manhattan Angel), heart ... Ann Ireland, 65, Canadian novelist, carcinoid syndrome. Dominik Kalata, 93, Slovak Roman Catholic prelate, Titular Bishop of ... heart disease. Richard D. Alexander, 88, American evolutionary biologist. Ted Atkins, 60, British mountaineer, climbing ... heart attack. Kin Sugai, 92, Japanese actress (Godzilla, Dodes'ka-den, The Funeral), heart failure. Mohammed Awad al-Zayyud, 62 ...
... and heart disease. Quantitation of urinary 5-HIAA is the best test for carcinoid, but scrupulous care must be taken that ... Midgut carcinoids are most apt to produce carcinoid syndrome with 5-HIAA elevation. Patients with renal disease may have ... 5-HIAA may be normal with nonmetastatic carcinoid tumor and may be normal even with the carcinoid syndrome, particularly in ... Such patients include those with celiac disease, tropical sprue, Whipple disease, stasis syndrome, and cystic fibrosis. It is ...
... and as a form of congenital heart disease. It is the most common valvular heart disease in pregnancy. Other causes include ... Other rare causes include mitral annular calcification, endomyocardial fibroelastosis, malignant carcinoid syndrome, systemic ... Mitral stenosis is a valvular heart disease characterized by the narrowing of the opening of the mitral valve of the heart. It ... Chapter 1: Diseases of the Cardiovascular system > Section: Valvular Heart Disease in: Elizabeth D Agabegi; Agabegi, Steven S ...
Stage IV disease requires addition of cisplatin-based chemotherapy in addition to those in stage II and III. For those with ... It contains the heart, esophagus, trachea, thymus, and aorta. The most common mediastinal masses are neurogenic tumors (20% of ... Tonofibrils seen under electron microscopy can differentiate thymoma from other tumors such as carcinoid, Hodgkin's, and ... disease; (2) Teratoma and cyst. Many signs and symptoms of a mediastinal tumor do not distinguish between these two principal ...
It can detect both intra and extra-adrenal disease. The imaging is highly sensitive and specific. Iobenguane concentrates in ... It also accumulates in norepinephrine transporters in adrenergic nerves in the heart, lungs, adrenal medulla, salivary glands, ... 2007). "Anatomic and functional imaging of metastatic carcinoid tumors". Radiographics. 27 (2): 455-77. doi:10.1148/rg. ... carcinoid tumors, neuroblastomas, and medullary thyroid cancer. Thyroid blockade with (nonradioactive) potassium iodide is ...
... cell type 209 Neuroendocrine tumors 209.0 Malignant carcinoid tumors of the small intestine 209.1 Malignant carcinoid tumors of ... 202.5 Letterer-Siwe disease 202.6 Malignant mast cell tumors 202.7 Peripheral T-cell lymphoma 202.8 Other lymphomas 202.9 Other ... heart, and mediastinum 165 Malignant neoplasm of other and ill-defined sites within the respiratory system and intrathoracic ... poorly differentiated neuroendocrine carcinoma 209.4 Benign carcinoid tumors of the small intestine 209.5 Benign carcinoid ...
They are usually caused by the effect of a cancer on the part of the body where it is growing, although the disease can cause ... These clots may disrupt circulation locally or dislodge and travel to the heart, lungs, or brain, and may be fatal. Symptoms of ... Examples include the production of parathyroid hormones by parathyroid tumors or serotonin by carcinoid tumors. In these cases ... Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body ...
... disease 10% of patients have extra-adrenal (paraganglioma) disease 10% of patients have inherited (familial disease) Despite ... An elevated heart rate (tachycardia) and the feeling of a racing heart (palpitations) may follow after initiating an alpha- ... "Neuroendocrine Cancer Survivor Featured on Discovery Fit & Health TV Show". Carcinoid Cancer Foundation. 2012-07-08. Retrieved ... "Rare Disease Day 2021 - 28 Feb". Rare Disease Day - 28 Feb 2021. Retrieved 2020-08-26. "Home". NORD (National Organization for ...
You need to be signed in to access email alerts. If you have an account log in with your user name and password. If you dont have an account you can just enter your email address in the email box below ...
Carcinoid Heart Disease-Induced Right-Sided Heart Failure as a Culprit for Significant Ascites Case Rep Gastroenterol (March, ... Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. ... Hepatic resection for the carcinoid syndrome in patients with severe carcinoid heart disease: does valve replacement permit ... Carcinoid heart disease (CHD; Table 1) is an uncommon presentation of carcinoid syndrome, but it does eventually occur in a ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
Malignant carcinoid syndrome is the constellation of symptoms typically exhibited by patients with metastases from carcinoid ... Carcinoid heart disease associated with primary ovarian carcinoid tumor. Am J Cardiol. 2004 May 15. 93(10):1314-5. [QxMD ... Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation. 2005 Nov 22. 112(21):3320-7. [QxMD ... Primary ovarian carcinoid heart disease curatively treated with a two-stage procedure. Thorac Cardiovasc Surg. 2007 Oct. 55(7): ...
Carcinoid syndrome develops in about 50% of the population with neuroendocrine tumors (1). Carcinoid heart disease manifests in ... Carcinoid heart disease: clinical and echocardiographic spectrum in 74 patients. Circulation. 1993;87:1188-1196. ... Risk factors for the development and progression of carcinoid heart disease. Am J Cardiol. 2011;107:1221-1226. ... We report a case of carcinoid heart disease that was managed successfully by such therapy (177Lu-DOTATATE), with a documented ...
Symptoms of carcinoid crisis include flushing, hypotension, arrhythmia and bronchospasm. Carcinoid heart disease is the result ... "Carcinoid Heart Disease: Review of Current Knowledge". Texas Heart Institute Journal. 46 (1): 21-27. doi:10.14503/THIJ-17-6562 ... an echocardiogram is recommended for evaluation of carcinoid heart disease. Other conditions similar to the carcinoid syndrome ... Heart Disease: About 60-70% of the those affected by carcinoid syndrome develop cardiac complications. This mainly affects the ...
Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed) ... Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid ... carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome. BMC Cancer. 2019 Mar 28; ... The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by ...
Carcinoid heart disease. If high levels of the hormone serotonin are produced over a long time, this can cause thickening of ... the heart valves and can lead to failure of the heart.. Carcinoid syndrome. A condition where some NETs produce increased ... Carcinoid. Term first coined in 1906 to describe a tumour that grew much more slowly than usual cancers. "Carcinoid" was ... Goblet cell carcinoid (GCC). GCC starts in the appendix and has features of both a NET and a faster growing type of cancer ...
Carcinoid syndrome is complicated in 60% of the cases of a heart disease, and is responsible for an important morbidity and ... The prognosis of patients with carcinoid heart disease has improved in recent years through somatostatin analogues and the ... the case of a 53-year-old African woman with an endocrine tumor of her small intestine complicated by carcinoid heart disease, ... It is related to the release by the carcinoid tumor and/or its metastases of bioactive substances such as serotonin. It is ...
Malignant carcinoid syndrome is the constellation of symptoms typically exhibited by patients with metastases from carcinoid ... Carcinoid heart disease associated with primary ovarian carcinoid tumor. Am J Cardiol. 2004 May 15. 93(10):1314-5. [QxMD ... Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation. 2005 Nov 22. 112(21):3320-7. [QxMD ... Primary ovarian carcinoid heart disease curatively treated with a two-stage procedure. Thorac Cardiovasc Surg. 2007 Oct. 55(7): ...
The relationship between carcinoid syndrome and carcinoid heart disease - a condition that affects the heart valves and results ... Managing metastatic disease. The prognosis (outlook or chance of recovery) for patients with carcinoid tumors is based ... The location of origin of carcinoid tumors is divided into three categories:. *Foregut Carcinoid Tumors - These tumors ... The underlying causes of carcinoid tumors.. *The risk factors that can increase a persons chances for developing a carcinoid ...
Carcinoid heart diseases affect in more than half percent of the patients with the carcinoid tumors, got from the midgut ... Carcinoid Heart Disease. Posted on June 22, 2018. August 16, 2018. By mnh93811 ... The Central Minnesota Heart Center at St. Cloud Hospital also known as MN Heart is a comprehensive cardiac care center ... The Heart Center is committed to providing excellent patient care, attracting high-caliber staff and developing state-of-the- ...
Carcinoid heart disease. Heidi M Connolly, MD (Uptodate). *Ebsteins anomaly of the tricuspid valve. Brojendra N Agarwala, MD ... The correct answer is: A. Carcinoid Heart Disease. The echocardiogram above shows severe tricuspid regurgitation due to leaflet ... This is a feature consistent with carcinoid heart disease.. Ebsteins anomaly is a congenital malformation of the tricuspid ... Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients. Circulation 1993; 87:1188 ...
Carcinoid heart disease. S Rooney, Birmingham. 10:30. Break. 11:00. Diagnosis and management of pulmonary embolism. F Taghavi, ... EACTS/GHC-PASCaTS Excellence Award for Rheumatic Heart Valve Disease and Management of Associated Tricuspid Regurgitation ... The 35th EACTS Annual Meeting turns Spains second city into the heart of the cardiothoracic world in October ... Management of right ventricular failure in the setting of mitral valve disease. N Marsan, Leiden. ...
... the heart doesnt get enough blood. Know the symptoms, causes and treatment of this type of heart valve disease. ... When the valve between the left heart chambers is narrowed, ... Tricuspid valve disease, Carcinoid heart disease, Constrictive ... Heart disease, Angina, Heart attack, Coronary artery disease, Heart valve disease, Mitral valve stenosis, Mitral valve ... Tricuspid valve disease, Ventricular septal defect, Fistula, Ischemic heart disease ...
"Locked Tricuspid Valve" in Carcinoid Heart Disease. Ayako Sekine, Takatomo Watanabe, Genki Naruse, Ayae Takada, Shingo Fuj ... ... chronic kidney disease, oral anticoagulant use at discharge, and heart failure were significantly associated with CRB. ... Epicardial adipose tissue (EAT) is located between the surface of the heart and the visceral layer of the pericardium and ... Many clinical studies suggest that an increase in EAT volume is associated with coronary artery disease. It has been reported ...
Surgical management of carcinoid heart disease. Richard P. Embrey> ;The Annals of Thoracic Surgery. 1993 May 1 ... Does the Centers for Disease Controls NNIS system risk index stratify patients undergoing cardiothoracic operations by their ... Relief of aortic obstruction in {S,L,L} hearts with rudimentary right ventricle and restrictive bulboventricular foramen ...
Malignant carcinoid syndrome is the constellation of symptoms typically exhibited by patients with metastases from carcinoid ... Carcinoid heart disease associated with primary ovarian carcinoid tumor. Am J Cardiol. 2004 May 15. 93(10):1314-5. [QxMD ... Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation. 2005 Nov 22. 112(21):3320-7. [QxMD ... Primary ovarian carcinoid heart disease curatively treated with a two-stage procedure. Thorac Cardiovasc Surg. 2007 Oct. 55(7): ...
Malignant carcinoid syndrome is the constellation of symptoms typically exhibited by patients with metastases from carcinoid ... Carcinoid heart disease occurs primarily on the right side of the heart but may involve the left side to a minimal degree. ... Carcinoid heart disease is reported in approximately 50-60% of all patients with malignant carcinoid syndrome and is severe in ... Carcinoid heart disease associated with primary ovarian carcinoid tumor. Am J Cardiol. 2004 May 15. 93(10):1314-5. [QxMD ...
Ergotamine has been associated with numerous vascular complications but only rarely with fibrosing disorders or valvular heart ... disease. Two patients are described in whom severe valvular dysfunction developed during ergotamine therapy for migraine ... strikingly similar to lesions described in patients with carcinoid heart disease and methysergide-associated valvular disease. ... Mitral and aortic valve disease associated with ergotamine therapy for migraine. Report of two cases and review of literature ...
The Association of a Panel of Biomarkers with the Presence and Severity of Carcinoid Heart Disease: A Cross-Sectional Study ... Chronobiological considerations for exercise and heart disease. Sports Med, 36 :487-500 DOI Author Url Publisher Url ... EXPLORATORY ASSESSEMENT OF SIMULTANEOUS LEFT VENTRICULAR STRAIN AND VOLUME IN CHRONIC SEVERE AORTIC VALVE DISEASE HEART, Annual ... Predominance of normal left ventricular geometry in the male athletes heart HEART, 100 :1264-1271 DOI Author Url Publisher ...
Carcinoid syndrome can be diagnosed through a combination of medical history, physical examination, laboratory tests, and ... Carcinoid syndrome is a rare condition that can occur in people with carcinoid tumors, which are slow-growing tumors that can ... Carcinoid heart disease: Carcinoid syndrome can cause damage to the heart valves, leading to heart failure. ... What is Carcinoid Syndrome?. Carcinoid syndrome is a rare condition that can occur in people with carcinoid tumors, which are ...
Carcinoid Heart Disease: A Guide for Clinicians. PMID: 31587790. Perry D, Hayek SS.Cardiol Clin. 2019 Nov;37(4):497-503. doi: ... Council on the Kidney in Cardiovascular Disease; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; ... Dose-dependent effect of smoking on risk of coronary heart disease, heart failure and stroke in individuals with type 1 ... Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Lifestyle and Cardiometabolic Health; ...
Carcinoid tumors (~10%) - carcinoid syndrome *Flushing, wheezing, diarrhea, carcinoid heart disease. *Vasoactive intestinal ... CAP - Neuroendocrine Tumors (Carcinoid Tumors) of the Appendix College of American Pathologists (CAP). Protocol for the ... CAP - Neuroendocrine Tumors (Carcinoid Tumors) of the Stomach College of American Pathologists (CAP). Protocol for the ... Carcinoid tumor - testing depends on tumor location *ACTH, gastrin, βhCG, somatostatin, pancreatic polypeptide, serotonin, ...
A carcinoid tumor that shows atypical characteristics and has borderline malignant potential. ... Cardiac Imaging in Carcinoid Heart Disease.. Baron T, Bergsten J, Albåge A, Lundin L, Sörensen J, Öberg K, Flachskampf FA. JACC ... Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management.. Jin C, Sharma AN, Thevakumar B, ... Disease*Neoplasm*Neoplasm by Special Category*Neoplasm by Obsolete Classification*Epithelial Neoplasm (Antiquated)*Carcinoid ...
Gigantism, maple syrup urine disease and ochoa are just a few. What makes these diseases so rare? ... Learn about the top 20 rare diseases that exist in humans. ... but it can develop into carcinoid heart disease, which thickens ... rare disease#scurvy#Situs Inversus#top 20 rare diseases#trigger thumb#Wilsons disease ... Extremely Rare Diseases Are More Common Than You Think. There are 7,000 identified extremely rare diseases, and its thought ...
Carcinoid heart disease in patients with neuroendocrine tumours: prevalence and predisposing factors ...
... expert physicians in an informal setting on issues ranging from NET cancer treatments and surgery to carcinoid heart disease to ... Sinai Medical Center and founder of the Carcinoid Heart Center in New York City. ... Richard R.P. Warner, world-renowned carcinoid/NET specialist, Director of the Center for Carcinoid and Neuroendocrine Tumors at ... The Big Apple Noids support group invites you to join fellow carcinoid and neuroendocrine tumor (NET) patients and three ...
... and 5-hydroxyindoleacetic acid in screening for carcinoid heart disease. Research output: Contribution to journal/Conference ... Signs of non-alcoholic fatty liver disease in indigenous Arctic populations - a systematic review. Research output: ...

No FAQ available that match "carcinoid heart disease"

No images available that match "carcinoid heart disease"