A plant of the family APIACEAE which is the source of asiatic acid and asiaticoside. Centella asiatica (L.) Urb. = Hydrocotyle asiatica L. is known for effect on peripheral circulation.
Five-ring derivatives of dammarane having a chair-chair-chair-boat configuration. They include the lupanes, oleananes, amyrins, GLYCYRRHIZIC ACID, and soyasaponins.
Triterpenes are a class of naturally occurring compounds consisting of six isoprene units arranged to form a 30-carbon skeleton, often found in plants and some animals, with various bioactivities including anti-inflammatory, antiviral, and cytotoxic properties.
Methods for cultivation of cells, usually on a large-scale, in a closed system for the purpose of producing cells or cellular products to harvest.

Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. (1/25)

Ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, were isolated from the aerial parts of Centella asiatica (L.) Urban cultivated in Sri Lanka together with madecassoside, asiaticoside, asiaticoside B, and sceffoleoside A. The chemical structures of centellasaponins B, C, and D were determined on the basis of chemical and physicochemical evidence to be madecassic acid 28-O-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside, madasiatic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyra noside, and 3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyra noside, respectively.  (+info)

Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. (2/25)

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.  (+info)

Hepatotoxicity associated with the ingestion of Centella asiatica. (3/25)

BACKGROUND: Hepatotoxicity due to herbal remedies is being increasingly recognized. Centella asiatica (Centella asiatica Linn Urban) is commercialized for multiple conditions. Its active principles are pentacyclic triterpenic saponosides (asiaticoside, madecassoside). CLINICAL CASE STUDIES: We present three women (61, 52 and 49 years old) who developed jaundice after taking Centella asiatica for 30, 20 and 60 days. Respective laboratory tests: ALT: 1193, 1694 and 324 U/L; ALP: 503, 472 and 484 U/L; bilirubin: 4.23, 19.89 and 3.9 mg/dl. The first patient also had ASMA 1/160 and AMA 1/320. Respective pathological diagnoses: granulomatous hepatitis with marked necrosis and apoptosis; chronic hepatitis with cirrhotic transformation and intense necroinflammatory activity, and granulomatous hepatitis. All patients improved with Centella asiatica discontinuation, and ursodeoxycholic acid 10 mg/kg/day. The first patient took Centella asiatica again, with recurrence of the damage. The second one had taken this herb a year before. CONCLUSIONS: Many plants synthesize hepatotoxic compounds. Germander, Skullcap and Glycyrrhizin contain di- or triterpenic active principles, which can produce hepatic injury by promoting apoptosis and altering cell membranes. We hypothesize that these mechanisms may have resulted in injuries associated with Centella asiatica. The presence of autoantibodies and granulomas also favors an immune-mediated mechanism. Ursodeoxycholic acid has anti-apoptotic properties, but we cannot rule out that Centella asiatica discontinuation alone may have resulted in patient improvement.  (+info)

Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban. (4/25)

A cDNA encoding farnesyl diphosphate synthase (FPS; EC2.5.1.1/EC2.5.1.10) was isolated from Centella asiacita (L.) Urban, using degenerate primers based on two highly conserved domains. A full-length cDNA clone was subsequently isolated by rapid amplification of cDNA ends (RACE) PCR. The sequence of the CaFPS (C. asiatica farnesyl diphosphate synthase) cDNA contains an open reading frame of 1029 nucleotides encoding 343 amino acids with a molecular mass of 39.6 kDa. The deduced CaFPS amino acid sequence exhibits 84, 79, and 72%, identity to the FPSs of Artemisia annua, Arabidopsis thaliana, and Oryza sativa, respectively. Southern blot analysis suggested that the C. asiatica genome contains only one FPS gene. An artificially expressed soluble form of the CaFPS was identified by SDS-PAGE. It had high specific activity and produced farnesyl diphosphate as the major isoprenoid.  (+info)

Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts. (5/25)

Centella asiatica (CA) and Rhinacanthus nasutus (RN )have been used for treatment of various illnesses, but the mechanisms of action remain largely unknown. This study focused on the influence of CA and RN extracts on cell-mediated and humoral immune responses. In human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha. In contrast, an ethanol extract of CA inhibited human PBMC mitogenesis and the production of IL-2 and TNF-alpha. BALB/c mice treated with CA extracts (100 mg/kg bw) showed higher responses to both primary and secondary antibodies against BSA when compared with non-treated group. Only the secondary antibody response was increased in RN extract-treated mice. The present study revealed immunomodulating activity of CA and RN extracts with regard to both non-specific cellular and humoral immune responses. The data available to date suggest that they may have chemopreventive or anticancer potential.  (+info)

In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. (6/25)

Medicinal plants have many traditional claims including the treatment of ailments of infectious origin. In the evaluation of traditional claims, scientific research is important. The objective of the study was to determine the presence of antibacterial activity in the crude extracts of some of the commonly used medicinal plants in Malaysia, Andrographis paniculata, Vitex negundo, Morinda citrifolia, Piper sarmentosum, and Centella asiatica. In this preliminary investigation, the leaves were used and the crude extracts were subjected to screening against five strains of bacteria species, Methicillin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli, using standard protocol of Disc Diffusion Method (DDM). The antibacterial activities were assessed by the presence or absence of inhibition zones and MIC values. M. citrifolia, P. sarmentosum and C. asiatica methanol extract and A. paniculata (water extract) have potential antibacterial activities to both gram positive S. aureus and Methicillin Resistant S. aureus (MRSA). None of the five plant extracts tested showed antibacterial activities to gram negative E. coli and K. pneumoniae, except for A. paniculata and P. sarmentosum which showed activity towards P. aeruginosa. A. paniculata being the most potent at MIC of 2 g/disc. This finding forms a basis for further studies on screening of local medicinal plant extracts for antibacteria properties.  (+info)

The anti-thrombotic active constituents from Centella asiatica. (7/25)

The in vitro effects of a methanol extract from the aerial parts of Centella asiatica on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to haemostatometry. 3,5-Di-O-caffeoyl quinic acid, 1,5-di-O-caffeoyl quinic acid, 3,4-di-O-caffeoyl quinic acid, 4,5-di-O-caffeoyl quinic acid, and chlorogenic acid, together with asiaticoside, kaempferol, quercetine, kaempferol-3-O-beta-D-glucoside and quercetin-3-O-beta-D-glucoside were all isolated from the methanol extract. Amongst these, only 3,5-di-O-caffeoylquinic acid showed significant inhibition of shear-induced platelet activation and dynamic coagulation. The reactive curve of the inhibitory effect on the platelet reaction and the dynamic coagulation showed a bell-shape.  (+info)

Dechlorophyllation by electrocoagulation. (8/25)

Electrocoagulation was used for dechlorophyllation of alcoholic extracts from five plants. The results showed that for every plant extract studied, electrocoagulation was more efficient than the classical solvent extraction method in removing plant pigments, while not affecting the important secondary metabolites in those extracts.  (+info)

"Centella" is the common name for a plant species known scientifically as *Centella asiatica*, also referred to as gotu kola. It is a herb that has been used in traditional medicine in various cultures, including Ayurvedic and Chinese medicine, for its potential health benefits. The active compounds in centella include saponins called asiaticoside, madecassoside, and madasiatic acid, which are believed to have anti-inflammatory, antioxidant, and wound-healing properties.

Centella has been studied for its potential effects on various conditions, such as anxiety, cognitive function, and skin health. However, more research is needed to confirm these potential benefits and establish recommended dosages and safety guidelines. As with any supplement or medication, it's important to consult with a healthcare provider before using centella to ensure that it's appropriate for your individual health needs and to avoid potential interactions with other medications.

Pentacyclic triterpenes are a type of natural compounds that are characterized by their structure, which consists of five cyclic rings made up of 30 carbon atoms. They are formed from squalene through a series of enzymatic reactions and can be found in various plants, as well as some animals and marine organisms.

Pentacyclic triterpenes have been studied for their potential medicinal properties, including anti-inflammatory, antiviral, and antitumor activities. Some examples of pentacyclic triterpenes include oleanolic acid, ursolic acid, and betulinic acid, which are found in a variety of fruits, vegetables, and herbs.

It's worth noting that while there is a growing body of research on the potential health benefits of pentacyclic triterpenes, more studies are needed to fully understand their mechanisms of action and therapeutic potential.

Triterpenes are a type of natural compound that are composed of six isoprene units and have the molecular formula C30H48. They are synthesized through the mevalonate pathway in plants, fungi, and some insects, and can be found in a wide variety of natural sources, including fruits, vegetables, and medicinal plants.

Triterpenes have diverse structures and biological activities, including anti-inflammatory, antiviral, and cytotoxic effects. Some triterpenes are also used in traditional medicine, such as glycyrrhizin from licorice root and betulinic acid from the bark of birch trees.

Triterpenes can be further classified into various subgroups based on their carbon skeletons, including squalene, lanostane, dammarane, and ursane derivatives. Some triterpenes are also modified through various biochemical reactions to form saponins, steroids, and other compounds with important biological activities.

Batch cell culture techniques refer to a method of growing cells in which all the necessary nutrients are added to the culture medium at the beginning of the growth period. The cells are allowed to grow and multiply until they exhaust the available nutrients, after which the culture is discarded. This technique is relatively simple and inexpensive but lacks the ability to continuously produce cells over an extended period.

In batch cell culture, cells are grown in a closed system with a fixed volume of medium, and no additional nutrients or fresh medium are added during the growth phase. The cells consume the available nutrients as they grow, leading to a decrease in pH, accumulation of waste products, and depletion of essential factors required for cell growth. As a result, the cells eventually stop growing and enter a stationary phase, after which they begin to die due to lack of nutrients and buildup of toxic metabolites.

Batch cell culture techniques are commonly used in research settings where large quantities of cells are needed for experiments or analysis. However, this method is not suitable for the production of therapeutic proteins or other biologics that require continuous cell growth and protein production over an extended period. For these applications, more complex culture methods such as fed-batch or perfusion culture techniques are used.

  • Sprague Dawley rats were treated with alcohol extract of Centella asiatica orally in two doses (20 and 40 mg/kg/day) for 3 mo along with intraperitoneal injection of carbon tetrachloride (1 ml/kg). (ijpsonline.com)
  • The therapeutic activity of a triterpenoid extract of Centella asiatica was observed in chronic hepatic disorders [ 3 ]. (ijpsonline.com)
  • The present study reports the protective effects of a water-dispersable extract of Centella asiatica leaves in CCl 4 -induced liver injury in rats. (ijpsonline.com)
  • Efficacy of Standardized extract of Centella asiatica (ECa 233) on cognitive function and mood in healthy elderly subjects: a randomized, double-blind, placebo-controlled study. (supaveda.com)
  • Dengan kandungan bahan aktif Centella Asiatica Extract, Niacinamide, Sodium Hyaluronate, Bentonite dan Kaolin membantu membersihkan pori-pori, mengurangi whitehead, mencerahkan, dan membuat kulit menjadi sangat halus. (tokopedia.com)
  • The Unscented Serum's ingredients of Ceramide, Sodium Hyaluronate, and Centella strengthen the skin barrier, starting from its roots. (oo35mm.com)
  • Hypocholesterolemic effect of Centella asiatica in rats fed a high-cholesterol diet. (supaveda.com)
  • A study on the effect of Centella asiatica extract on learning and memory in healthy volunteer. (supaveda.com)
  • Centella Extract offers a synergistic effect with the brightening functional ingredients, Niacinamide and Peptide, that soothes damaged skin and activates the skin's protective film, providing a strong boosting effect. (oo35mm.com)
  • The active ingredients of the Centella Asiatica just prevent the growth of melanin and help to tone the skin. (skinrecipe.eu)
  • The ingredients in the Centella Asiatica are rich in water, minerals, and antioxidants that help hydrate effectively. (skinrecipe.eu)
  • We have upgraded the product's safety while maintaining its great effects by taking essential oils out of the PURITO Centella Green Level Buffet Serum. (oo35mm.com)
  • The PURITO Centella Unscented line products are free from artificial fragrances and essential oils, therefore natural scent may arise from the raw materials themselves. (puritoen.com)
  • Check out Natural Beauty's Centella Revitalizing Anti-Wrinkle Cream! (strawberrynet.com)
  • De Revuele Centella Repairing Face Gel Cream is een milde cleanser die perfect is voor een doffe huid en tekenen van vermoeidheid, bij elk huidtype! (boozyshop.nl)
  • Apply a generous amount of Centella Green Level Recovery Cream. (oo35mm.com)
  • The Erborian ultra-fine Centella Cleansing Oil removes makeup (including waterproof), excess sebum and impurities, while maintaining the skin's natural hydration. (ulta.com)
  • Das Centella Cleansing Gel von Erborian ist eine sanfte Reinigung auf Ölbasis, die Ihre Haut klärt und beruhigt. (parfumdreams.de)
  • Das Centella Cleansing Gel von Erborian reinigt die Haut sanft, befreit sie von Unreinheiten und optimiert das Hautbild. (parfumdreams.de)
  • The Centella Unscented Toner not only soothes irritation but also helps to improve skin texture, restore moisture, and strengthen the skin barrier. (puritoen.com)
  • Centella asiatica (Linn) Urban, Synonym Hydrocotyle asiatica , belongs to the family Umbelliferae. (ijpsonline.com)
  • Have you been hesitating to use the existing Centella Green Level Buffet Serum because your damaged skin has gotten more sensitive because of the change in season, particulate matter, and pollution? (oo35mm.com)
  • Brahmi/gotu kola (Centella asiatica) is a vibrant green water-loving herb. (banyanbotanicals.com)
  • The common name Brahmi can also refer to a completely different plant gotu kola (Centella asiatica) that has similar medicinal properties to bacopa. (msdmanuals.com)
  • Compounds in the Centella Asiatica help promote collagen regeneration. (skinrecipe.eu)
  • The non-irritating toner contains 10% Centella Asiatica Extract to soothe the skin through its active compounds, Asiaticoside, Asiatic Acid, and Madecassic Acid. (puritoen.com)
  • Centella asiatica contains active compounds such as triterpenoids, flavonoids, and phenolic acids, which are thought to be responsible for its medicinal properties. (blogmalaysia.com)
  • The active compounds in centella asiatica have been shown to have anti-inflammatory and antioxidant properties. (blogmalaysia.com)
  • In this study, we have evaluated Centella asiatica compounds for their activity on aromatase with clinically significant SNPs rs700519, rs78310315 and rs56658716. (bvsalud.org)
  • Natural Beauty's Centella Revitalizing Supreme Ampoule 7 Days, an anti-aging booster, penetrates deeply into skin, keeping it firm and glowy! (strawberrynet.com)
  • Skin1004 introduces CENTELLA AMPOULE FOAM, a rich, foaming cleanser specifically designed with the ideal pH level of 5. (dearlucy.us)
  • Calming ampoule with 100% centella asiatica extract for sensitive skin. (gorgeoustyles.com)
  • Centella Asiatica is a small herbaceous plant native to certain regions in Asia, including India, China, and Southeast Asia. (strawberrynet.com)
  • The Centella Asian is a perennial herbaceous plant of the Apiacee family and common in the tropical and subtropical humid regions of India and South America. (procosmet.com)
  • The synergistic effect of 49% Centella Extract, which promotes the synthesis of collagen, and Niacinamide provides excellent effects of skin regeneration and skin problem/scar soothing. (oo35mm.com)
  • A study conducted in rats found that the administration of Centella asiatica leaf powder prevented mortality rate due to gross protein deficiency, increased blood protein nitrogen and prevented fatty infiltration of liver [ 2 ]. (ijpsonline.com)
  • Centella Asiatica, traditionally used for its ultra-soothing and comforting properties, is the star ingredient in this cleanser. (ulta.com)
  • Book in for a full facial and receive a Centella Cleanser as a compliment to your facial routine! (whitewillow.ie)
  • Centella Asiatica is a rich source of antioxidants, which play a vital role in fighting against free radicals and oxidative stress. (strawberrynet.com)
  • Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health parameters in male rats. (supaveda.com)
  • The antioxidants found in Centella Asiatica help neutralise these harmful free radicals, minimising their impact on the skin and reducing the signs of premature aging. (strawberrynet.com)
  • Centella asiatica, also known as Gotu Kola, is a medicinal herb native to India, Sri Lanka, and other parts of Asia. (blogmalaysia.com)
  • Pegaga, juga dikenali sebagai Centella asiatica dalam bahasa saintifik, adalah tumbuhan perubatan yang biasa digunakan dalam perubatan tradisional Melayu. (blogmalaysia.com)
  • Dalam perubatan tradisional Melayu, pegaga atau Centella asiatica sering digunakan sebagai tumbuhan perubatan. (blogmalaysia.com)
  • It was observed that in male Wistar rats, the administration of asiaticoside derivatives of Centella asiatica caused the restoration of 40% of the damaged liver cells to normal state [ 4 ]. (ijpsonline.com)
  • Chemical studies on Centella asiatica leaves showed that one of the major components is asiaticoside [ 5 ]. (ijpsonline.com)
  • Whether you're dealing with acne scars, sun damage, or other skin imperfections, Centella Asiatica can help rejuvenate and restore your skin's natural beauty. (strawberrynet.com)
  • Centella Asiatica, also known as Tiger Grass, has been revered for centuries for its powerful healing properties. (strawberrynet.com)
  • Known by many names, including Tiger Grass, Centella Asiatica Extract helps nourish skin and soothe irritation. (puritoen.com)
  • Centella Asiatica contains pentacyclic triterpenoids, which improve blood circulation and stimulate the regeneration of new skin cells. (skinrecipe.eu)
  • Centella asiatica is also known as gotu kola and is often used in herbal teas and supplements to support cognitive function and reduce anxiety. (blogmalaysia.com)
  • That's why we developed at Centella a slimming program over 4 weeks, a real "boot camp" that maximizes the exceptional properties of our slimming products and their assets. (centella.com)
  • From 22 February - 12 March we offer FREE SHIPPING within Ireland on our skincare products online, including Centella, HydraFlore, Jouvé and our new skincare line - Lucim. (whitewillow.ie)
  • And could heal damage tissue and tight skin, prevent hygrodermia, detumescence detoxification and remove abscess.Centella asiatica extract can also be used in the burn healing.Scar repair, anti-wrinkle, anti-aging, acne, and other personal care products have broad market prospects. (dongyuanbiotech.com)
  • The Centella Asiatica is a really gentle ingredient in cosmetic products. (skinrecipe.eu)
  • Many skincare products now include centella asiatica as an ingredient due to its ability to improve skin elasticity and reduce the appearance of fine lines and wrinkles. (blogmalaysia.com)
  • According to some sources, the name Centella derives from the Latin "centrum", with reference to the almost circular aspect of the leaves. (procosmet.com)
  • This product contains 49% highly-concentrated Centella Extract that has excellent effects of skin regeneration and recovery. (oo35mm.com)
  • Gotu Kola (Centella asiatica) is an herb traditionally used in Ayurvedic medicine for its various health benefits. (supaveda.com)
  • Whether you're looking to improve skin elasticity, fade scars, reduce inflammation, or enhance your overall skin health, Centella Asiatica is a natural solution worth exploring. (strawberrynet.com)
  • Combination of oral and topical Centella asiatica (CA) is expected to treat dry skin in T2DM patients more effectively through decreasing N(6)-carboxymethyl-lysine (CML) and interleukin-1 α (IL-1 α ) and increasing superoxide dismutase (SOD) activity. (hindawi.com)
  • Centella Asiatica improves oil balance and helps the dermis layer to enhance collagen synthesis and boost skin elasticity. (elikoglow.ca)
  • Centella is 100% organic, chemical & toxic free, vegan and cruelty free skincare suitable for all skin types and concerns. (whitewillow.ie)
  • Centella asiatic extract is commonly high in skin-profiting phytochemicals. (dongyuanbiotech.com)
  • It is the madecassiccorrosive substance in Centella Asiatica that is answerable for this - thiscompound is frequently found in spot medicines and items for imperfectioninclined skin. (dongyuanbiotech.com)
  • If your skin after breakout, Centella Asiatica will regenerate, soothe, and heal your skin. (skinrecipe.eu)
  • Contains Centella Asiatica Extract that effectively improve unwell skin problems, saying goodbye to redness and other sensitive skin problems. (mumuso.jo)
  • The present study was conducted to evaluate the hepatoprotective effects of the Centella asiatica extract in carbon tetrachloride-induced liver injury in rats. (ijpsonline.com)
  • Centella asiatica (CA) or commonly known as pegagan in Indonesia is widely used as a traditional remedy, and its benefits had been scientifically proven [ 7 ]. (hindawi.com)
  • Centella Extract - is a commonly known medicinal plant called Gotu Kola and is mostly used in Asia for various kinds of ailments. (haokhome.store)
  • Centella asiatica is a medicinal herb that has been used for centuries in traditional Ayurvedic and Chinese medicine. (blogmalaysia.com)
  • Besides its rejuvenating and healing properties, Centella Asiatica is known for its soothing and anti-inflammatory effects. (strawberrynet.com)
  • In addition, Centella Asiatica - Centella Asiatica also contains saponins (Asian acid, brahmic acid), which increase the connections between cell tissues, help heal wounds quickly and effectively help treat acne. (skinrecipe.eu)
  • De laatste jaren is het begrip vegan steeds belangrijker voor veel dames, en dat snapt Boozyshop! (boozyshop.nl)
  • Als je een liefhebber bent van de natuur en de dieren en een vegan lifestyle voor jou erg belangrijk is, hoef je jouw vegan levensstijl niet meer te beperken tot alleen vegan voeding. (boozyshop.nl)
  • Van vegan mascara en vegan eyeliner tot vegan foundation en vegan concealer… Jouw hele make-up stash kan vegan zijn! (boozyshop.nl)
  • With a rich history in traditional medicine and a growing body of scientific research, Centella Asiatica is taking the skincare world by storm. (strawberrynet.com)
  • Laat je e-mailadres achter en we sturen je een mailtje wanneer dit product weer op voorraad is. (boozyshop.nl)
  • I've found this centella scrub by accident and I'm so thankful for that because this is the only product that seriously works and helps me combat my hair loss problems. (haokhome.store)
  • Centella Asiatica is also called as the elixir of youth, Cica, Tiger Gross or Gotu Kola. (skinrecipe.eu)
  • This Centella Scrub is contained with a powerful, yet gentle active formula that works together to ensure a faster-growing healthier hair. (haokhome.store)