A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
Spinal neoplasms are abnormal growths or tumors that develop within the spinal column, which can be benign or malignant, and originate from cells within the spinal structure or spread to the spine from other parts of the body (metastatic).
The last bone in the VERTEBRAL COLUMN in tailless primates considered to be a vestigial tail-bone consisting of three to five fused VERTEBRAE.
The body region between (and flanking) the SACRUM and COCCYX.
The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE.
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Neoplasms of the bony part of the skull.
A benign neoplasm derived from mesodermal cells that form cartilage. It may remain within the substance of a cartilage or bone (true chondroma or enchondroma) or may develop on the surface of a cartilage (ecchondroma or ecchondrosis). (Dorland, 27th ed; Stedman, 25th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A cartilaginous rod of mesodermal cells at the dorsal midline of all CHORDATE embryos. In lower vertebrates, notochord is the backbone of support. In the higher vertebrates, notochord is a transient structure, and segments of the vertebral column will develop around it. Notochord is also a source of midline signals that pattern surrounding tissues including the NEURAL TUBE development.

Recurrence of clival chordoma along the surgical pathway. (1/174)

Chordomas are locally aggressive malignant tumors of notochordal origin whose metastatic potential is increasingly recognized. Surgical pathway recurrence has been noted only rarely in the literature. We present three patients with clival chordomas whose sole or initial recurrence was along the pathway of prior surgical access. A characteristic mass found along the pathway of prior surgical access for resection of a chordoma should suggest recurrent chordoma.  (+info)

Sacral chordoma--a case report. (2/174)

Chordoma, a rare malignant tumour of early adulthood, rarely presents in children. We report such a case of rare malignant tumour which was diagnosed in the first decade of life.  (+info)

Isolated cardiac metastasis from sacral chordoma. (3/174)

A 64-year-old woman presented with right heart failure caused by a cardiac tumor centered in the free wall of the right ventricle, accompanied by pericardial effusion. A match between the biopsy specimen and tissue removed 4 years earlier resulted in the diagnosis of a cardiac metastasis from a chordoma. Immunohistochemical staining was also useful in establishing the diagnosis. To alleviate the right ventricular outflow obstruction, a palliative operation was planned, resecting the tumor and performing a right ventriculoplasty, which was cancelled due to the extent of infiltration of the tumor, and instead a right atrium to pulmonary artery shunt was attempted using a vascular prosthesis, only to fail due to an inability to maintain blood flow through the prosthesis. Presently there are no definitive treatment options available, and some palliative chemotherapy is being performed. Single cardiac metastases from a chordoma are extremely rare.  (+info)

Chordoid glioma: a neoplasm unique to the hypothalamus and anterior third ventricle. (4/174)

BACKGROUND AND PURPOSE: Chordoid glioma is a new clinicopathologic entity that occurs in the region of the hypothalamus/anterior third ventricle. The aims of this study were to describe the characteristic radiographic features of chordoid glioma, identify specific imaging features that may enable differentiation of chordoid glioma from other suprasellar tumors, and increase neuroradiologists' awareness of this newly described tumor, facilitating prospective diagnosis. METHODS: CT scans and/or MR images of six patients with chordoid glioma were reviewed retrospectively to determine whether any characteristic radiographic features would emerge. Reports of the clinical presentation, pathologic findings, and radiographic findings of another six patients were reviewed and included, for a total patient population of 12 (mean age +/- SD, 46 +/- 13 years). RESULTS: Imaging features were strikingly similar for all tumors. In each case, the mass was ovoid, was well circumscribed, was located in the region of the hypothalamus/anterior third ventricle, and enhanced uniformly and intensely. Tumors were hyperdense to gray matter on CT scans and were isointense on T1-weighted MR images and slightly hyperintense on long-TR MR images. In two patients, vasogenic edema extended into the optic tracts, and in three, there was hydrocephalus. CONCLUSION: Chordoid glioma is a recently described unique histopathologic entity that has been added to the World Health Organization glioma classification scheme and must be included in the differential diagnosis of a suprasellar mass. Distinctive imaging features are its location, ovoid shape, hyperdensity on CT scans, and uniform intense contrast enhancement.  (+info)

Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development. (5/174)

Chordoma is the fourth most common malignant primary neoplasm of the skeleton and almost the only one showing a real epithelial phenotype. Besides classic chordoma, so-called chondroid chordoma was described as a specific entity showing cartilage-like tissue within chordomatoid structures. However, since its first description, strongly conflicting results have been reported about the existence of chondroid chordoma and several studies suggested chondroid chordomas being in fact low-grade conventional chondrosarcomas. In the present study, we used cytoprotein expression profiling and molecular in situ localization techniques of marker gene products indicative of developmental phenotypes of chondrocytes to elucidate origin and biology of chondroid chordoma. We were able to demonstrate the chondrogenic potential of chordomas irrespectively of the appearance of overt cartilage formation by identifying the multifocal expression of type II collagen, the main marker of chondrocytic differentiation. Additionally, the cartilage-typical large aggregating proteoglycan aggrecan was present throughout all chordomas and, thus, a very characteristic gene product and marker of these neoplasms. Biochemical matrix composition and cell differentiation pattern analysis showed a high resemblance of classic chordomas and in chordoid areas of chondroid chordomas to the fetal chorda dorsalis, whereas chondroid areas of chondroid chordomas showed features similar to adult nucleus pulposus. This demonstrates on the cell function level the chondrocytic differentiation potential of neoplastic chordoid cells as a characteristic facet of chordomas, mimicking fetal vertebral development, ie, the transition of the chorda dorsalis to the nucleus pulposus. Our study firmly establishes a focal real chondrocytic phenotype of neoplastic cells in chordomas. Chondroid chordoma is neither a low-grade chondrosarcoma nor a misnomer as discussed previously.  (+info)

Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. (6/174)

Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during midlife. We performed a genomewide analysis for linkage in a family with 10 individuals affected by chordoma. The maximum two-point LOD score based on only the affected individuals was 2.21, at recombination fraction 0, at marker D7S2195 on chromosome 7q. Combined analysis of additional members of this family (11 affected individuals) and of two unrelated families (one with 2 affected individuals and the other with 3 affected individuals), with 20 markers on 7q, showed a maximum two-point LOD score of 4.05 at marker D7S500. Multipoint analysis based on only the affected individuals gave a maximum LOD score of 4.78, with an approximate 2-LOD support interval from marker D7S512 to marker D7S684. Haplotype analysis of the three families showed a minimal disease-gene region from D7S512 to D7S684, a distance of 11.1 cM and approximately 7.1 Mb. No loss of heterozygosity was found at markers D7S1804, D7S1824, and D7S2195 in four tumor samples from affected family members. These results map a locus for familial chordoma to 7q33. Further analysis of this region, to identify this gene, is ongoing.  (+info)

Tentorial enhancement on MR images is a sign of cavernous sinus involvement in patients with sellar tumors. (7/174)

BACKGROUND AND PURPOSE: This study was undertaken to analyze enhancement patterns of the dura around sellar tumors and to compare the results with tumor invasion or compression of the cavernous sinuses. Postoperative enhancement patterns on MR images were compared with preoperative findings. METHODS: Contrast-enhanced coronal and sagittal MR images were examined prospectively in 96 patients with sellar tumors (65 macroadenomas, 15 microadenomas, 14 Rathke cleft cysts, and two chordomas at the sella). All patients underwent surgical treatment, and pre- and postsurgical features on MR images were compared. RESULTS: Presurgical MR images showed dural enhancement in 36.5% of the patients: asymmetric tentorial enhancement in 24 patients, symmetric tentorial enhancement in seven, and sphenoidal ridge or clivus enhancement in four. Asymmetric tentorial enhancement disappeared after surgical decompression in seven patients. For evaluation of cavernous sinus invasion ipsilateral to the enhancement, sensitivity and specificity of the asymmetric tentorial enhancement sign were 81.3% and 86.3%, respectively. Sensitivity and specificity of the sign were 42.9% and 93.6% for cavernous sinus involvement, including compression and invasion. CONCLUSION: Asymmetric tentorial enhancement is a useful sign in the diagnosis of invasion or severe compression of the cavernous sinus by sellar tumor. The sign may represent venous congestion or collateral flow in the tentorium due to obstructed flow in the medial portion of the cavernous sinus.  (+info)

Vertebral reconstruction with cortical allograft: long-term evaluation. (8/174)

Reconstruction of large anterior vertebral column defects is indicated in a number of pathological conditions including tumor, infection, trauma and post-traumatic deformity. Several substitutes and techniques are available for the functional restoration of the vertebral column. Vascularized bone transfers, autografts, allografts or xenografts have been used, as well as metal or ceramic implants. All of these bear potential advantages and drawbacks in terms of associated morbidity of graft harvesting, disease transmission, mechanical failure, implant incorporation and overall long-term clinical outcome. In the present paper we report our experience with the use of freeze-dried, gamma-irradiated, cortical allograft for the reconstruction of large, anterior segmental defects of the spine, involving at least one vertebral body with its two adjacent discs. Cortical allografts were used in 67 cases operated for a variety of conditions. No case of disease transmission, infection or long-term mechanical graft failure occurred in our entire series, with a mean follow-up of 31 months. Fusion and mechanical stability was reliably obtained. Specific advantages include the absence of donor site morbidity, the possibilities for exact trimming to the size of the defect, superior mechanical strength as compared to available autograft, and reliable fusion with the host bone with partial bone remodeling, preventing fatigue failure. We conclude that freeze-dried, irradiated cortical allografts are safe and effective for anterior reconstruction of the spine.  (+info)

A chordoma is a rare, slow-growing tumor that typically develops in the bones of the spine or skull. These tumors originate from remnants of the notochord, a structure that forms during embryonic development and eventually becomes part of the spinal cord. Chordomas are usually low-grade malignancies but can be aggressive and locally invasive, potentially causing pain, neurological symptoms, or structural damage to the spine or skull. Treatment typically involves surgical resection, often combined with radiation therapy.

Skull base neoplasms refer to abnormal growths or tumors located in the skull base, which is the region where the skull meets the spine and where the brain connects with the blood vessels and nerves that supply the head and neck. These neoplasms can be benign (non-cancerous) or malignant (cancerous), and they can arise from various types of cells in this area, including bone, nerve, glandular, and vascular tissue.

Skull base neoplasms can cause a range of symptoms depending on their size, location, and growth rate. Some common symptoms include headaches, vision changes, hearing loss, facial numbness or weakness, difficulty swallowing, and balance problems. Treatment options for skull base neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The specific treatment plan will depend on the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history.

The sacrum is a triangular-shaped bone in the lower portion of the human vertebral column, located between the lumbar spine and the coccyx (tailbone). It forms through the fusion of several vertebrae during fetal development. The sacrum's base articulates with the fifth lumbar vertebra, while its apex connects with the coccyx.

The sacrum plays an essential role in supporting the spine and transmitting weight from the upper body to the pelvis and lower limbs. It also serves as an attachment site for various muscles and ligaments. The sacral region is often a focus in medical and chiropractic treatments due to its importance in spinal stability, posture, and overall health.

Spinal neoplasms refer to abnormal growths or tumors found within the spinal column, which can be benign (non-cancerous) or malignant (cancerous). These tumors can originate in the spine itself, called primary spinal neoplasms, or they can spread to the spine from other parts of the body, known as secondary or metastatic spinal neoplasms. Spinal neoplasms can cause various symptoms, such as back pain, neurological deficits, and even paralysis, depending on their location and size. Early diagnosis and treatment are crucial to prevent or minimize long-term complications and improve the patient's prognosis.

The coccyx, also known as the tailbone, is the small triangular bone at the bottom of the spine in humans and other primates. It is formed by the fusion of several small vertebrae and serves to attach muscles and ligaments in the pelvic region. The coccyx can be a source of pain and discomfort if it is injured or becomes inflamed.

The sacrococcygeal region is the lower part of the back where the spine ends, specifically referring to the area where the sacrum (a triangular bone at the base of the spine formed by the fusion of several vertebrae) meets the coccyx (also known as the tailbone). This region is located at the very bottom of the spine and is susceptible to injury or trauma due to its position and role in supporting the body's weight. It is also a common site for birth defects, particularly in newborns.

The posterior cranial fossa is a term used in anatomy to refer to the portion of the skull that forms the lower, back part of the cranial cavity. It is located between the occipital bone and the temporal bones, and it contains several important structures including the cerebellum, pons, medulla oblongata, and the lower cranial nerves (IX-XII). The posterior fossa also contains the foramen magnum, which is a large opening through which the spinal cord connects to the brainstem. This region of the skull is protected by the occipital bone, which forms the base of the skull and provides attachment for several neck muscles.

Chondrosarcoma is a type of cancer that develops in the cartilaginous tissue, which is the flexible and smooth connective tissue found in various parts of the body such as the bones, ribs, and nose. It is characterized by the production of malignant cartilage cells that can invade surrounding tissues and spread to other parts of the body (metastasis).

Chondrosarcomas are typically slow-growing tumors but can be aggressive in some cases. They usually occur in adults over the age of 40, and men are more commonly affected than women. The most common sites for chondrosarcoma development include the bones of the pelvis, legs, and arms.

Treatment for chondrosarcoma typically involves surgical removal of the tumor, along with radiation therapy or chemotherapy in some cases. The prognosis for chondrosarcoma depends on several factors, including the size and location of the tumor, the grade of malignancy, and whether it has spread to other parts of the body.

Skull neoplasms refer to abnormal growths or tumors that develop within the skull. These growths can be benign (non-cancerous) or malignant (cancerous). They can originate from various types of cells, such as bone cells, nerve cells, or soft tissues. Skull neoplasms can cause various symptoms depending on their size and location, including headaches, seizures, vision problems, hearing loss, and neurological deficits. Treatment options include surgery, radiation therapy, and chemotherapy. It is important to note that a neoplasm in the skull can also refer to metastatic cancer, which has spread from another part of the body to the skull.

A chondroma is a benign, slow-growing tumor that develops in the cartilage. Cartilage is a type of connective tissue found in various parts of the body, including the joints, ribcage, and nose. Chondromas are most commonly found in the hands and feet.

Chondromas are typically small, measuring less than 2 centimeters in diameter, and they usually do not cause any symptoms. However, if a chondroma grows large enough to press on nearby nerves or blood vessels, it may cause pain, numbness, or weakness in the affected area.

Chondromas are usually diagnosed through imaging tests such as X-rays, CT scans, or MRI scans. If a chondroma is suspected based on these tests, a biopsy may be performed to confirm the diagnosis and rule out other types of tumors.

Treatment for chondromas typically involves surgical removal of the tumor. In most cases, this can be done using minimally invasive techniques that allow for quicker recovery times. After surgery, patients will need to follow up with their healthcare provider to ensure that the tumor has been completely removed and to monitor for any signs of recurrence.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

The notochord is a flexible, rod-shaped structure that is present in the embryos of chordates, including humans. It is composed of cells called chordocytes and is surrounded by a sheath. The notochord runs along the length of the body, providing support and flexibility. In human embryos, the notochord eventually becomes part of the discs between the vertebrae in the spine. An abnormal or absent notochord can lead to developmental problems with the spine and nervous system.

In layman's terms, chordoma is a type of spinal cancer. Chordomas can arise from bone in the skull base and anywhere along the ... Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. In 2015 the first consensus guidelines for the ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ... Expert Recommendations for the Diagnosis and Treatment of Chordoma is a handbook produced by the Chordoma Foundation, which ...
A Chordoma is another type of cancer that slowly grows into nearby bones and many soft tissues in the spine, ranging from the ... Chordomas have around a 40% metastasis rate and mainly spread to the lungs. (rare cases) soft-tissue sarcoma causes: ... "Chordoma". Genetics Home Reference. Retrieved 2020-04-23. "Undifferentiated pleomorphic sarcoma - Symptoms and causes". Mayo ...
Lopes A, Rossi BM, Silveira CR, Alves AC (1996). "Chordoma: retrospective analysis of 24 cases". Sao Paulo Medical Journal = ... Hirsch EF, Ingals M (May 1923). "Sacrococcygeal chordoma". JAMA: The Journal of the American Medical Association. 80 (19): 1369 ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...
Virchow was the first to describe and name diseases such as leukemia, chordoma, ochronosis, embolism, and thrombosis. He coined ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ... Hirsch, Edwin F (1923). "Sacrococcygeal Chordoma". JAMA. 80 (19): 1369-1370. doi:10.1001/jama.1923.02640460019007. ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull). ...
"Understanding Chordoma - Chordoma Foundation". www.chordomafoundation.org. Retrieved 7 April 2017. King, Christine, BVSc, ... The sacrum is one of the main sites for the development of the sarcomas known as chordomas that are derived from the remnants ...
The evidence regarding brachyury's role in chordoma includes: Brachyury is highly expressed in all chordomas except for the ... A germline SNP in brachyury is present in 97% of chordoma patients. Somatic amplifications of brachyury are seen in a subset of ... Brachyury is implicated in the initiation and/or progression of a number of tumor types including chordoma, germ cell tumors, ... Brachyury is the most selectively essential gene in chordoma relative to other cancer types. Brachyury is associated with a ...
The cells are the likely precursors to a rare cancer called chordoma. Research into the notochord has played a key role in ... Pillai S, Govender S (2018). "Sacral chordoma : A review of literature". J Orthop. 15 (2): 679-684. doi:10.1016/j.jor.2018.04. ... Implications for Disk Degeneration and Chordoma Formation". Developmental Dynamics. 237 (12): 3953-3958. doi:10.1002/dvdy.21805 ...
Magrini SM, Papi MG, Marletta F, Tomaselli S, Cellai E, Mungai V, Biti G (Apr 1993). "Chordoma-natural history, treatment and ...
"Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma". U.S. National Institutes of Health. June 2022. " ... chordoma. "Erbitux- cetuximab solution". DailyMed. 27 September 2021. Retrieved 2 June 2022. "Erbitux EPAR". European Medicines ...
Chordomas, a rare bone tumour, might suggest defects in homologous recombination and mutations affecting HR-related genes. ... April 2019). "Defective homologous recombination DNA repair as therapeutic target in advanced chordoma". Nature Communications ...
Kasantikul V, Shuangshoti S (May 1989). "Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma". ...
The clivus is also the site for chordoma, a rare type of cancer. Surgery for lesions involving the clivus and surrounding ...
José Enrique was diagnosed with chordoma, a rare brain tumour, in May 2018. On 23 June 2018, he announced that he was ...
... a chordoma, or a chordoid meningioma. In particular, meningiomas are known to produce musical auditory hallucinations such as ...
Howard Copeland, 75, American politician, member of the Virginia House of Delegates (1981-1995), chordoma. Vijay Dev, 78, ...
"Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base (HIT-1)". ClinicalTrials.gov. ... Damien Weber (2016). "Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated ... Jinpeng Zhou (2018). "Comparison of the Effectiveness of Radiotherapy with Photons and Particles for Chordoma After Surgery: A ... These include, among others, uveal melanoma (ocular tumor), skull base and paraspinal tumor (chondrosarcoma and chordoma), and ...
Younessi had survived four bouts of cancer since an initial diagnosis of malignant chordoma in 2009. "EWP: Catalog & Student ...
Expanded Endoscopic Endonasal Approach for Resection of Intradural Chordoma: Surgical and Anatomic Nuances: 2-Dimensional ...
... is an American biomedical scientist researching the genetics of dysplastic nevus syndrome and chordoma, and ... Her research interests include the genetics of dysplastic nevi syndrome and chordoma, and etiologic heterogeneity of breast ... Yang identified the first susceptibility gene for familial chordoma-a germline duplication of the T gene that had eluded ...
PMID 18580797 Fraser JF, Nyquist GG, Moore N., Anand VK, Schwartz TH; Endoscopic endonasal transclival resection of chordomas: ...
Copeland was diagnosed with chordoma in August 2016, and died of the disease on April 11, 2019, aged 75. Ress, Dave (April 15, ...
BCRT funds research into primary bone cancer, in particular, osteosarcoma, Ewing's sarcoma, chondrosarcoma, chordoma, spindle ...
Techniques such as endoscopic endonasal surgery are used in pituitary tumors, craniopharyngiomas, chordomas, and the repair of ...
This approach is used to remove chordomas, chondrosarcoma, inflammatory lesions of the clivus, or metastasis in the cervical ... and clival chordomas (CHO). They looked at gross total resection and cerebrospinal fluid (CSF) leaks, neurological death, post- ...
Case Series of Ultrasonic Navigated Osteotomy for the Treatment of Spinal Chordomas. World Neurosurg. 2021 Mar 8:S1878-8750(21) ... Navigated Ultrasonic Osteotomy to Aid in En Bloc Chordoma Resection via Spondylectomy. World Neurosurg. 2020 Nov;143:319-324. ...
"Development of first immunotherapy to treat chordoma, a rare bone cancer." "Medical Oncology Service". Center for Cancer ...
... and Chordoma. The for-profit spin-off companies M4K Pharma (Medicines for Kids), M4ND Pharma (Medicines for Neurological ...
Tuấn Anh announced his break from singing and WanBi revealed that he had reduced eyesight as a side effect from the chordoma ...
The following list includes types of primary bone cancer: Osteosarcoma Chondrosarcoma Ewing's Sarcoma Adamantinomas Chordomas ...
Tennis announced in his column of November 19, 2009, that he has been diagnosed with a chordoma, a rare malignant tumor that ...
In laymans terms, chordoma is a type of spinal cancer. Chordomas can arise from bone in the skull base and anywhere along the ... Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. In 2015 the first consensus guidelines for the ... In one study, the 10-year tumor free survival rate for sacral chordoma was 46%. Chondroid chordomas appear to have a more ... Expert Recommendations for the Diagnosis and Treatment of Chordoma is a handbook produced by the Chordoma Foundation, which ...
Chordoma are midline tumors originating from embryonic remnants of the primitive notochord. They are considered to be low-grade ... Chordomas occur in the midline along the spinal axis from the clivus to the sacrum, anterior to the spinal cord. Chordomas are ... Morphology of chordoma. Contrast-enhanced sagittal T1-weighted spin-echo image. Chordoma of the upper part of the clivus with ... Morphology of chordoma. Contrast-enhanced sagittal T1-weighted spin-echo image. Chordoma of the upper part of the clivus with ...
Background and etiopathology Chordoma is a relatively rare malignant midline tumor arising in the axial skeleton, primarily at ... Chondroid chordoma--a variant of chordoma. A morphologic and immunohistochemical study. Am J Clin Pathol. 1994 Jan. 101 (1):36- ... encoded search term (Chordoma in Orthopedic Surgery) and Chordoma in Orthopedic Surgery What to Read Next on Medscape ... Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation. Am J Clin Pathol. 1995 Mar. 103 (3):271-9. [ ...
Improving the lives of those affected by chordoma. Leading the search for a cure. ... Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. Davies ... The Chordoma Foundation is recognized by the IRS as a 501(c)(3) non-profit organization, and donations are tax-deductible to ... 2023 Chordoma Foundation. All Rights Reserved. Consent Preferences , Privacy policy , Terms of use ...
Improving the lives of those affected by chordoma. Leading the search for a cure. ... Find a chordoma expert Our Doctor Directory can help you locate a doctor with chordoma expertise. ... In our private online community, Chordoma Connections, you can talk with and get support from other chordoma patients, ... Skull base chordomas often touch important nerves and blood vessels, so it is not always possible to remove the entire tumor. ...
... as part of the Chordoma Foundations Drug Screening Program. Information on the specific PDX and CDX models used for drug ...
An ER visit reveals chordoma, a rare cancer Neurosurgeon uses a 3D model to prepare for a 19-hour procedure. ... A neurosurgeon well-versed in chordoma. Geisinger neurosurgeon Sanjay Konakondla, MD, who trained under a world-renowned spinal ...
This video has been taken from En Bloc Resection of Upper Thoracic Chordoma via a Combined Simultaneous Anterolateral ...
Chordoma (also known as notochordal sarcoma) is a rare type of primary bone cancer that is commonly found at the bottom of the ... Chordoma is a slow-growing tumor, and the treatment is difficult because of the location of the disease which is near the ... Chordoma originates from remnants of embryonic notochord. It begins in the developing embryo, and when you are born, it may go ... These are factors to increase risk of having chordoma:. *Age. The disease commonly affects adult at age 40 - 60 years old but ...
But, on top of all that, the 26-year-old is in her second battle with chordoma, a rare type of bone cancer. ... But, on top of all that, the 26-year-old is in her second battle with chordoma, a rare type of bone cancer. ... At the age of 20, Nicole was first diagnosed with sacral-based chordoma at SCCA. At the time, proton therapy was unavailable in ... In March of 2016, Nicole was diagnosed with a recurrent mutated form of chordoma in her left sacroiliac joint, not far from ...
... have potent preclinical efficacy against chordoma. Our results generate an emerging map of chordoma dependencies to enable ... We apply genome-scale CRISPR-Cas9 loss-of-function screens to map the landscape of selectively essential genes in chordoma, a ... CDK6, SOX9, and EGFR, genes previously implicated in chordoma biology, are also recovered. We find genomic and transcriptomic ... This approach confirms a known chordoma dependency, TBXT (T; brachyury), and identifies a range of additional dependencies, ...
"Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33." Am J Hum Genet, vol. 69, no. 2, Aug. 2001, ... "Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33." Am J Hum Genet 69, no. 2 (August 2001): 454- ... Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33.. Publication , Journal Article ... Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. Am J Hum Genet. 2001 Aug;69(2):454-60. ...
Chordoma is a locally invasive tumor of low metastatic potential. Only six cases of chordoma that metastasized to the brain are ... The authors report a case of symptomatic brain metastasis from a sacrococcygeal chordoma in the absence of other metastases. ... Intracranial metastasis from a "giant" nonoperated sacrococcygeal chordoma: an underestimated metastatic potential? ...
What are the symptoms for spinal chordoma?. Numbness in the hands or feet symptom was found in the spinal chordoma condition. ... There are some risk factors for spinal chordoma:. *Youre more likely to get a spinal chordoma if you have multiple family ... Rarely, these leftover tissues give rise to chordomas.. About one-third of chordomas are found in the region around the clivus ... Symptoms of the presence of chordomas vary with their location and size. Most chordomas occur randomly among the population ( ...
Zdravljenje za chordoma vključujejo:. Operacija. Primarno zdravljenje akordov je operacija, čeprav jo je težko izvesti, ker je ... Chordoma je redek rakavi (maligni) primarni kostni tumor, ki se običajno pojavi vzdolž hrbtenice. Najpogosteje se akord pojavi ...
Chordoma. Chordoma research is led by a comprehensive team including Gary Gallia, M.D., director of the Neurosurgery Skull Base ... The team is also exploring high throughput drug screening using the chordoma model, and the molecular pathways responsible for ... and has established the first primary skull base chordoma xenograft mouse model. ...
chordoma. Please remember that these statistics are for everybody diagnosed with each type of cancer. The figures do not take ... Chordoma Around 55 out of 100 people (around 55%) survive their cancer for 5 years or more after diagnosis. ...
Chordoma. For more information, see Childhood Chordoma Treatment.. Carcinoma of Unknown Primary Site. For more information, see ...
Chordoma. Chordoma is an infrequent type of bone cancer affecting the bones of skull and spines. Chordoma usually arises in the ...
Chordomas are generally slow growing and are histologically considered low grade tumours. Their high recurrence rate even after ... This is particularly true for clival chordomas whose deep anatomic location and proximity to vital anatomic structures makes ... As expected, gross tumour removal reduced chordoma recurrence. The lower third of the clivus frequently harboured residual or ... Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities. ...
The Drew Barker-Wright Charity is dedicated to helping fund research and supporting families affected by Paediatric Chordoma. ... As chordoma is so rare it is important to identify all children with chordoma in the UK so that we can learn more about this ... We offer a grant system for newly diagnosed children with chordoma in the UK, to help parents through the shockwave of ... The Drew Barker-Wright Charity organises regular events to help raise funds for chordoma research and to help children and ...
Sacral Chordoma: Dont throw away the Scalpel. PubMed, SCI, Scopus, ESCI, PMC indexed ... While sacral chordomas that are from S3-S5 can be resected through a posterior only approach, the presence of anterior soft ... The patient is a 77-year-old male who five years ago had been treated for a sacral chordoma with SBRT presented to the ED with ... In this report we present a case of a gentleman with a sacral chordoma who was offered en bloc resection but elected to proceed ...
Chordoma, Cervical spine, Vertebral Chordoma, Spinal axis.. Introduction. Chordomas are rare neoplasms - as primary ... In one series of chordomas reviewed, the average age at diagnosis of all patients with chordomas was 56 years, with an age ... So for this case the chordoma located in the cervical spine is regarded as a rare place. Chordomas arise from embryonic ... With CT scans, chordomas at any site appear as single or multiple areas of decreased attenuation within the clivus, vertebrae, ...
Chordoma Treatment India, Chordoma Treatment Cost In India Info On Cost Chordoma Treatment Mumbai Delhi Bangalore India, ... Chordoma Treatment Doctors Surgeon India, Chordoma Treatment Hospitals India, Chordoma Treatment Center Mumbai India ... Chondroid chordomas tend to be less aggressive than conventional chordomas, while dedifferentiated chordomas are more ... Because chordomas do not grow rapidly, high doses of radiation are required to kill the tumor cells. Chordomas that are close ...
Chordoma UK is a registered charity spreading awareness of chordoma and raising funds to support chordoma research in the UK. ... Chordoma UK is a registered charity (RCN 1173201) Registered Office: The Long Barn. Down Farm, Cobham Park Road, Cobham, Surrey ... If you have any questions about Chordoma UK, or would like to talk to someone about cancer, send us an email and well get back ... Much of this work is done by volunteers; so from all at Chordoma UK to all our supporters a heartfelt THANK YOU. ...
BLK-MAX Hospital provides the best treatment for Chordoma, Book Doctors Appointment ... Chordoma Best Chordoma Treatment Hospital in Delhi Chordomas are rare tumors that develop from the notochord, a structure in ... The pathophysiology of chordomas is not well understood. Chordomas can cause pain, swelling, and difficulty moving. They can ... Chordoma is a rare type of cancer that affects the bones in the spine and skull. It can occur at any age but is most commonly ...
UK offers treatment for chordoma, pituitary tumours and aneurysms. Chordoma is a slow growing cancer of tissue found inside the ... What is Chordoma?. Chordoma is a rare, slow-growing malignant tumour that develops in the spine and skull bones. It is thought ... Symptoms of Chordoma. The most evident signs of chordoma are pain and neurological changes. Symptoms typical to a skull-based ... Treatment of Chordoma. Treatment of a chordoma involves removing the maximum possible amount of tumour tissue via surgery. ...
You are here: Home » publication » Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management ... Endoscopic Assistance for Resection of a craniovertebral Junction Chordoma. Endoscopic Assistance for Resection of a ... post-title Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management Strategies - Operative ... Vertebrobasilar Artery Encasement by Skull Base Chordomas: Surgical Outcome and Management Strategies - Operative Neurosurgery ...
Chordomas and chondrosarcomas are tumors that arise from developmental cells that are misplaced during development. ... Symptoms of Chordomas and Chondrosarcomas. Chordomas and chondrosarcomas often arise near the base of the skull, so symptoms ... Chordomas and chondrosarcomas can be distinguished from one another by location (chordomas tend to occur along the midline, ... Treatment of Chordomas and Chondrosarcomas. Treatment for both chordomas and chondrosarcomas includes complete surgical ...
  • Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. (wikipedia.org)
  • Chordomas and chondrosarcoma constitute the majority of malignant sacral tumors in adulthood. (fortuneonline.org)
  • With patients who present with locally advanced or metastatic chondrosarcoma, chordoma, or osteosarcoma, physicians should discuss the options surrounding deep-sequencing genomic tests, which may identify mutations that may be responsive to specific therapies and thus may guide referral to clinical trials. (medscape.com)
  • In the latest version of the guidelines released in November 2020, surgery is the main treatment for chondrosarcoma, chordoma, and giant cell tumor of bone, which can be combined with radiotherapy or targeted therapy. (bvsalud.org)
  • Sacral chordoma is presented with chronic low back pain. (wikipedia.org)
  • mTOR signaling is hyperactive in sporadic sacral chordomas: in one study 10 out of 10 sacral chordomas exhibited phosphorylation of Ribosomal protein s6 and EIF4EBP1 by immunohistochemistry Partial or complete PTEN (gene) deficiency is observed in nearly all sacral chordomas In a study of 49 chordomas Akt, TSC2, and EIF4EBP1 were phosphorylated in 92%, 96% and 98% of cases, respectively. (wikipedia.org)
  • Sacral chordomas make up 2 to 4% of all primary bone tumours and 44% of all primary sacral tumours, thus making it the most common malignant sacral tumour. (wikipedia.org)
  • Males aged between 40 and 50 years are twice as more common than women to get sacral chordoma. (wikipedia.org)
  • Chordomas are distributed as follows: 50% sacral, 35% skull base, and 15% in the vertebral bodies of the mobile spine (most commonly the C2 vertebrae, followed by the lumbar spine and then the thoracic spine). (medscape.com)
  • At the age of 20, Nicole was first diagnosed with sacral-based chordoma at SCCA. (fredhutch.org)
  • Sacral chordomas pose a difficult challenge for physicians due to the close proximity of neural, vascular, and visceral structures. (fortuneonline.org)
  • We report a complication of single dose intent to treat SBRT for a sacral chordoma that should serve to remind oncologists that radiation therapy, like surgery, is not without serious potential complications and that surgical resection may still be the best option for patients whose tumor can be treated with en bloc resection. (fortuneonline.org)
  • In this report we present a case of a gentleman with a sacral chordoma who was offered en bloc resection but elected to proceed with SBRT. (fortuneonline.org)
  • The patient is a 77-year-old male who five years ago had been treated for a sacral chordoma with SBRT presented to the ED with lumbosacral pain. (fortuneonline.org)
  • Purpose: To evaluate if baseline ADC from DWI sequences could predict response to treatment in patients with sacral chordoma not suitable for surgery treated with carbon ion radiotherapy (CIRT) alone compared with volume changes. (kl.ac.at)
  • Methods: Fifty-nine patients with sacral chordoma not suitable for surgery underwent one cycle of CIRT alone and a minimum of 12-months follow-up. (kl.ac.at)
  • There are no drugs currently approved to treat chordoma, however a clinical trial conducted in Italy using a tyrosine kinase inhibitor imatinib demonstrated a modest response in some chordoma patients. (wikipedia.org)
  • Chordomas are generally resistant to standard cytotoxic chemotherapy agents, and there are no drugs approved to treat chordoma. (indiahealthtour.com)
  • [ 5 ] Chordoma is the most common primary malignant tumor found in the sacrum. (medscape.com)
  • Malignant fibrous histiocytoma in chordoma--immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma. (medscape.com)
  • Under the microscope, chordoma cells appear to be benign, but because of their location, invasive nature, and recurrence rate, the tumors are considered to be malignant. (cancerhealthcenter.com)
  • However, some chordomas behave aggressively and have more malignant characteristics with extensive invasiveness including a small subset of patients (~10%) that develop metastases to distant sites beyond their site of origin. (indiahealthtour.com)
  • Chordoma is a rare, slow-growing malignant tumour that develops in the spine and skull bones. (kumarabhinavneurosurgeon.co.uk)
  • Background: Chordomas are malignant tumors arising from notochordal remnants and are typically locally aggressive tumors with a high propensity for local recurrence. (scitechnol.com)
  • Conclusion: Among primary malignant tumors of bone, chordomas account for 3-4% of all cases. (scitechnol.com)
  • Chordomas tumors are a rare but malignant tumor that can take place anywhere along the spine. (robertjbessmd.com)
  • However, the location of chordomas near important structures sometimes makes wide resection difficult or impossible. (chordomafoundation.org)
  • Published medical studies have shown that complete resection of skull base chordomas is associated with lower rates of recurrence and higher rates of survival. (chordomafoundation.org)
  • This is a video of the thoracoscopic procedure, demonstrating dissection of a plane between the tumor and mediastinum, protection of the esophagus and great vessels during osteotomies, and en bloc resection of the tumor. (spinesection.org)
  • This video has been taken from En Bloc Resection of Upper Thoracic Chordoma via a Combined Simultaneous Anterolateral Thoracoscopic and Posterior Approach, an article that can be read here http://bit.ly/1pXTCqV . (spinesection.org)
  • This is particularly true for clival chordomas whose deep anatomic location and proximity to vital anatomic structures makes surgical resection challenging. (entandaudiologynews.com)
  • Factors predicting recurrence after resection of clival chordoma using variable surgical approaches and radiation modalities. (entandaudiologynews.com)
  • When possible, en bloc surgical resection has been the recommended treatment for these tumors. (fortuneonline.org)
  • Current literature clearly demonstrates that wide en bloc resection with negative surgical margins is the single most important predictor of tumor recurrence and long term survival [1, 2]. (fortuneonline.org)
  • There are three histological variants of chordoma: conventional, chondroid and dedifferentiated. (wikipedia.org)
  • Chondroid chordomas appear to have a more indolent clinical course. (wikipedia.org)
  • In addition to conventional chordomas, chondroid chordomas, which are composed of cartilaginous hyaline tissue, have shorter T1- and T2-weighted MRI signals because of low water content. (medscape.com)
  • Chordoma and chondroid neoplasms of the spheno-occiput. (medscape.com)
  • Chondroid chordomas tend to be less aggressive than conventional chordomas, while dedifferentiated chordomas are more aggressive, faster growing and more likely to metastasize. (indiahealthtour.com)
  • Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. (chordomafoundation.org)
  • These results demonstrate the activity of pemetrexed in recurrent chordoma and warrant a prospective clinical trial which is ongoing (NCT03955042). (providence.org)
  • Management of locally recurrent chordoma of the mobile spine and sacrum: A systematic review. (bvsalud.org)
  • Nakamura Y, Becker LE, Marks A. S100 protein in human chordoma and human and rabbit notochord. (medscape.com)
  • Pemetrexed inhibited growth in a preclinical mouse xenograft model of human chordoma. (providence.org)
  • Surgery is typically the main treatment for newly diagnosed chordoma and can be one option for recurrent, advanced, and metastatic chordoma as well. (chordomafoundation.org)
  • Chordoma is a locally invasive tumor of low metastatic potential. (lenus.ie)
  • Sacrococcygeal chordoma metastatic to the brain with review of the literature. (lenus.ie)
  • Intracranial metastasis from a "giant" nonoperated sacrococcygeal chordoma: an underestimated metastatic potential? (lenus.ie)
  • Aspiration cytology of metastatic chordoma to the orbit. (lenus.ie)
  • Metastatic chordoma of the tongue: Case report. (lenus.ie)
  • We report three cases of metastatic chordoma that had been heavily treated previously with a variety of standard therapies with poor response. (providence.org)
  • Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. (wikipedia.org)
  • Chordomas are midline tumors originating from embryonic remnants of the primitive notochord. (medscape.com)
  • Demonstration of cytokeratins and an epithelial membrane antigen in chordomas and human fetal notochord. (medscape.com)
  • Chordoma originates from remnants of embryonic notochord. (vejthani.com)
  • Chordomas are rare tumours arising from notochord cell nests. (spinalsurgerynews.com)
  • Chordomas are locally invasive tumors that arise from the remnant of the primitive notochord. (indiahealthtour.com)
  • Chordomas are rare tumors that develop from the notochord, a structure in the embryo that gives rise to the spine. (blkmaxhospital.com)
  • Chordomas develop from remnants of the notochord, a structure that appears in embryonic stages and guides the growth of the bony skull and spine. (neurosurgeonsofnewjersey.com)
  • A chordoma occurs when additional notochord cells are enclosed by the developing bones. (neurosurgeonsofnewjersey.com)
  • Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. (providence.org)
  • Chordomas can arise from bone in the skull base and anywhere along the spine. (wikipedia.org)
  • Because of local invasion, many tumors (especially skull-base chordomas) may not be amenable to complete surgical excision, and the local recurrence rate is high. (medscape.com)
  • A systematic review by Bin-Alamer et al assessed SRS with or without postoperative fractionated radiation therapy in adults with skull-base chordomas. (medscape.com)
  • Surgery to remove skull base chordomas can either be done endoscopically, using a small scope through the nose or mouth, or through the side of the head. (chordomafoundation.org)
  • For suspected cases of skull base chordoma, biopsies are often performed at the time of surgery to help reduce the risks involved. (chordomafoundation.org)
  • Skull base chordomas often touch important nerves and blood vessels, so it is not always possible to remove the entire tumor. (chordomafoundation.org)
  • When 66-year-old Frank DiTaranto of Lewisburg went to the ER with neck pain, numbness and trouble balancing, tests revealed a rare type of cancer that occurs in the spine and the base of the skull: chordoma. (geisinger.org)
  • Chordoma (also known as notochordal sarcoma) is a rare type of primary bone cancer that is commonly found at the bottom of the spine (sacrum) and base of skull. (vejthani.com)
  • Chordomas are very rare primary bone tumors that can arise at almost any point along the axis of the spine from the base of the skull to the sacrum and coccyx (tailbone). (cancerhealthcenter.com)
  • Chordomas occur with equal frequency in the skull base, the vertebrae and the sacrococcygeal area towards the bottom of the spine. (cancerhealthcenter.com)
  • Chordoma is an infrequent type of bone cancer affecting the bones of skull and spines. (yesdoct.com)
  • Chordomas can occur anywhere along the spine but are most common in the base of the skull and the lower back. (blkmaxhospital.com)
  • Chordomas are tumors that grow in the spinal cord, skull, or base of the skull. (blkmaxhospital.com)
  • Chordoma is a rare type of cancer that affects the bones in the spine and skull. (blkmaxhospital.com)
  • Symptoms typical to a skull-based chordoma include headache, issues with vision such as double vision, and pain in the neck region. (kumarabhinavneurosurgeon.co.uk)
  • Chordomas can occur anywhere along the spinal axis, but are most common at the top of the spine (the skull base) and the bottom of the spine (the sacrum). (neurosurgeonsofnewjersey.com)
  • Chondrosarcomas, which are even rarer than chordomas, are tumors of the cartilage that the skull replaces during development, although their exact origin is unclear. (neurosurgeonsofnewjersey.com)
  • Chordomas and chondrosarcomas often arise near the base of the skull, so symptoms may be caused when they begin to affect the nearby cranial nerves and the brainstem. (neurosurgeonsofnewjersey.com)
  • Trifiletti, DM & Brown, PD 2020, ' Proton and carbon ion therapy for skull base chordomas ', Neuro-oncology , vol. 22, no. 9, pp. 1241-1242. (elsevierpure.com)
  • Chordomas occur in the midline along the spinal axis from the clivus to the sacrum, anterior to the spinal cord. (medscape.com)
  • Chordoma of the upper part of the clivus with posterior extension to the pontine cistern. (medscape.com)
  • Clivus chordoma with posterior extension into the pontine cistern and compression of brainstem. (medscape.com)
  • About one-third of chordomas are found in the region around the clivus. (cancerhealthcenter.com)
  • Chordomas generally occur in 3 locations, which are, in descending order of frequency, the sacrum, intracranially at the clivus, and along the spinal axis. (spinalsurgerynews.com)
  • approximately 40% of chordomas and chondrosarcomas arise in the clivus. (indiahealthtour.com)
  • The risk of chordoma is increased if a direct member of the family is diagnosed with the disease. (vejthani.com)
  • By making healthy lifestyle choices and taking precautions to avoid exposure to known risk factors, patients can lower their risk of chordoma. (blkmaxhospital.com)
  • In the meantime, the best way to reduce your risk of chordoma is to be aware of the signs and symptoms and see a doctor right away if you think you might have chordoma. (blkmaxhospital.com)
  • Scholars@Duke publication: Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. (duke.edu)
  • Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during midlife. (duke.edu)
  • Chordomas arise from embryonic notochordal remnants along the length of the neuraxis at developmentally active sites. (spinalsurgerynews.com)
  • Chordomas are thought to arise from primitive notochordal remnants along the axial skeleton. (spinalsurgerynews.com)
  • Chordoma is a rare bone cancer that is believed to originate from notochordal remnants. (johnshopkins.edu)
  • Most patients with a clival chordoma develop headaches and double vision. (indiahealthtour.com)
  • Intensity modulated radiation therapy (IMRT), stereotactic radiosurgery and carbon-ion radiotherapy are also sometimes used to treat chordoma. (indiahealthtour.com)
  • We feel passionately about funding specific projects to help progress chordoma research and improve the chances of survival for other children and their families. (dbwcharity.org)
  • Chordoma is a very rare bone tumor for which the five-year relapse-free survival rate plateaus at 50%, making chordoma a therapeutic challenge despite aggressive treatment. (cancerresearch.org)
  • Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. (wikipedia.org)
  • These results map a locus for familial chordoma to 7q33. (duke.edu)
  • Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma. (johnshopkins.edu)
  • We sequenced all T exons in 24 familial cases and 54 unaffected family members from eight chordoma families (three with T duplications), 103 sporadic cases, and 160 unrelated controls. (johnshopkins.edu)
  • Our findings further highlight the importance of the T gene in the pathogenesis of both familial and sporadic chordoma and suggest a complex susceptibility related to T. (johnshopkins.edu)
  • The authors report a case of symptomatic brain metastasis from a sacrococcygeal chordoma in the absence of other metastases. (lenus.ie)
  • Chordomas and chondrosarcomas are tumors that arise from developmental cells that are misplaced during development. (neurosurgeonsofnewjersey.com)
  • Because outcome and prognosis are largely dependent on the success of the initial surgery, before having any operation it is very important to get multiple opinions from surgical teams who have experience treating chordomas on a regular basis. (indiahealthtour.com)
  • Treatment for both chordomas and chondrosarcomas includes complete surgical excision of the tumor with radiation therapy as a follow-up. (neurosurgeonsofnewjersey.com)
  • Chordomas are considered to be low-grade neoplasms, locally aggressive, and slow-growing but highly recurrent. (medscape.com)
  • Most chordomas occur randomly among the population (sporadic). (cancerhealthcenter.com)
  • Chordomas and chondrosarcomas can be distinguished from one another by location (chordomas tend to occur along the midline, while chondrosarcomas are shifted to the sides) and through examination under a microscope. (neurosurgeonsofnewjersey.com)
  • As expected, gross tumour removal reduced chordoma recurrence. (entandaudiologynews.com)
  • Chordoma is typically a locally aggressive tumor with a high propensity for local recurrence. (scitechnol.com)
  • This folder contains the results of testing various drugs in patient and cell-derived xenograft models (PDX and CDX respectively) as part of the Chordoma Foundation's Drug Screening Program. (figshare.com)
  • Object Chordoma cells may generate solid-like tumors in xenograft choices that express some molecular features of the mother or father tumor including positivity for brachyury and cytokeratins. (cell-signaling-pathways.com)
  • So for this case the chordoma located in the cervical spine is regarded as a rare place. (spinalsurgerynews.com)
  • Method: We report an extremely rare case of cervical spine chordoma presenting with neurological deficit and retropharyngeal extension in order to assess the clinical presentation and treatment. (scitechnol.com)
  • citation needed] Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled. (wikipedia.org)
  • The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered. (wikipedia.org)
  • Read more on the Radiation for chordoma page of our website. (chordomafoundation.org)
  • Because chordomas do not grow rapidly, high doses of radiation are required to kill the tumor cells. (indiahealthtour.com)
  • Chordomas that are close to critical structures (arteries, brain, brainstem, cranial nerves, dura, spinal nerves), often limit the dose of radiation that can be safely delivered to the tumor. (indiahealthtour.com)
  • Chordoma can be treated with surgery, radiation therapy, or chemotherapy, depending on the stage of the cancer. (blkmaxhospital.com)
  • Symptoms of the presence of chordomas vary with their location and size. (cancerhealthcenter.com)
  • What are the symptoms for spinal chordoma? (cancerhealthcenter.com)
  • We briefly present this case of chordoma, discussing the symptoms and signs, the radiological features and management including excision and replacement of the defect with bone graft. (spinalsurgerynews.com)
  • If you are experiencing any of the signs or symptoms of chordoma, it's important to seek medical attention right away. (blkmaxhospital.com)
  • Recently, a common genetic variant in T (rs2305089) was significantly associated with the risk of sporadic chordoma. (johnshopkins.edu)
  • In addition, we identified three rare variants that were only observed among sporadic chordoma cases, all of which have potential functional relevance based on in silico predictions. (johnshopkins.edu)
  • Finally, we did not observe T duplication in any sporadic chordoma case. (johnshopkins.edu)
  • The most complete immune signature of chordomas will be established by using complementary techniques enabling a molecular, proteic, spatial profile of the IME, how it interacts with tumor cells, and the effects of the IME on tumor cells at the molecular level. (cancerresearch.org)
  • Integrative analyses of molecular, biological, and clinical data will allow for a whole picture of the chordoma immunone, its interconnections with tumor cells at the molecular level, and will lead to the identification of predictive factors of therapeutic response to targeted and immune-therapies. (cancerresearch.org)
  • Even though chordomas usually are slow-growing tumours, they are locally aggressive with a tendency to infiltrate into adjacent tissues and organs. (spinalsurgerynews.com)
  • Dedifferentiated chordomas are sometimes treated with chemotherapy to kill rapidly multiplying cells. (indiahealthtour.com)
  • In cases of advanced chordoma, chemotherapy may slow down the growth of the tumour or temporarily arrest the progression of the disease. (kumarabhinavneurosurgeon.co.uk)
  • Chordoma is a slow-growing tumor, and the treatment is difficult because of the location of the disease which is near the nerves of the spinal cord. (vejthani.com)
  • Regression of cervical spinal cord compression in a patient with chordoma following treatment with cetuximab and gefitinib. (lu.se)
  • citation needed] In the United States, the annual incidence of chordoma is approximately 1 in one million (300 new patients each year). (wikipedia.org)
  • The incidence, sites, and factors predictive of chordoma metastasis are discussed. (lenus.ie)
  • The incidence of chordoma in the general U.S. population is about 8 per 10,000,000 people. (cancerhealthcenter.com)
  • About 50 to 60% of chordomas are located in the sacrococcygeal region. (wikipedia.org)
  • In 2015 the first consensus guidelines for the diagnosis and treatment of chordoma were published in The Lancet Oncology. (wikipedia.org)
  • Treatment options, cure rates and research for paediatric chordoma fall well beneath other childhood cancers. (dbwcharity.org)
  • Currently, surgery is the first-line treatment for chordomas. (indiahealthtour.com)
  • Some medical centers have multidisciplinary teams of experts who review cases and can help create a coordinated treatment plan for patients with chordomas. (indiahealthtour.com)
  • There is no one-size-fits-all answer for chordoma treatment, as the best approach depends on the individual case. (blkmaxhospital.com)
  • In some cases, chordoma may recur after treatment. (blkmaxhospital.com)
  • Treatment of a chordoma involves removing the maximum possible amount of tumour tissue via surgery. (kumarabhinavneurosurgeon.co.uk)
  • Molecularly targeted cancer drugs are also gaining popularity as a treatment approach for chordomas. (kumarabhinavneurosurgeon.co.uk)
  • Chordoma-Current Understanding and Modern Treatment Paradigms. (nih.gov)
  • Available at https://rarediseases.org/rare-diseases/chordoma/ . (medscape.com)
  • But, on top of all that, the 26-year-old is in her second battle with chordoma, a rare type of bone cancer. (fredhutch.org)
  • As chordoma is so rare it is important to identify all children with chordoma in the UK so that we can learn more about this disease. (dbwcharity.org)
  • The Drew Barker-Wright Charity organises regular events to help raise funds for chordoma research and to help children and families affected by this rare childhood cancer. (dbwcharity.org)
  • One was a chordoma, a rare type of bone cancer, and the other was a squamous cell carcinoma of the head and neck. (medscape.com)
  • Clival chordomas represent less than 0.2% of all intracranial tumors. (medscape.com)
  • Intracranial metastasis from a sacrococcygeal chordoma. (lenus.ie)
  • Chordomas account for approximately 3% of all bone tumors. (medscape.com)
  • We offer a grant system for newly diagnosed children with chordoma in the UK, to help parents through the shockwave of diagnosis. (dbwcharity.org)
  • Chordomas are generally slow growing and are histologically considered low grade tumours. (entandaudiologynews.com)
  • We hope this will represent the first step towards the initiation of clinical trials of promising new drugs for paediatric chordoma. (dbwcharity.org)
  • Activity of pemetrexed in pre-clinical chordoma models and humans. (providence.org)
  • and Mini Gill, Jaya, "Activity of pemetrexed in pre-clinical chordoma models and humans. (providence.org)
  • To answer these questions, the presented project regroup a unique chordoma cohort, gathering untreated chordoma, chordoma from pembrolizumab-treated chordoma (from the Acsé Pembro clinical trial, erlotinib treated chordoma from clinical practice, and regorafenib-treated chordoma from the Regobone trial. (cancerresearch.org)
  • Her project will enable the design of future clinical trials in which tailored treatments will be adapted to chordoma specificities. (cancerresearch.org)
  • Differential diagnosis between chordoma and invasive pituitary adenoma. (medscape.com)
  • Cell Tradition Two chordoma cell lines were acquired for comparative purposes through a materials transfer agreement with the Chordoma Basis: human being chordoma cell lines U-CH1 and U-CH2b (University or college Hospital of Ulm Germany). (cell-signaling-pathways.com)
  • In a tissue microarray containing 21 chordomas Platelet-derived growth factor receptor-beta (PDGFR-b), epidermal growth factor receptor (EGFR), KIT (CD117) and HER2 were detected in 100%, 67%, 33% and 0% of cases, respectively. (wikipedia.org)
  • Erlotinib-like EGFR inhibitors have been also reported to be effective in chordoma. (wikipedia.org)
  • Although EGFR mutation is not present in chordoma, EGFR expression might predict response to erlotinib (as shown in report by Dr Sameer Rastogi). (wikipedia.org)
  • Morphology of chordoma. (medscape.com)
  • Outcomes The DVC-4 cells maintained chordoma-like morphology in lifestyle and exhibited Compact disc24 and brachyury appearance information in UNC0631 vitro which were just like those for U-CH1 and U-CH2b. (cell-signaling-pathways.com)
  • In four of these families, duplication of the brachyury gene was found to be responsible for causing chordoma. (wikipedia.org)