Choroid Plexus Neoplasms
Choroid Plexus
Papilloma, Choroid Plexus
Choroid
Brachial Plexus
Cerebral Ventricle Neoplasms
Cerebrospinal Fluid
Myenteric Plexus
Ependyma
Submucous Plexus
Meninges
Choroid Neoplasms
Blood-Brain Barrier
Celiac Plexus
Lumbosacral Plexus
Cervical Plexus
Imaging features of intraventricular melanoma. (1/71)
We present the MR imaging findings in a patient with symptoms of increased intracranial pressure and a mass in the left lateral ventricle. The mass showed increased signal intensity on T1-weighted images and low signal intensity on T2-weighted images. The histologic diagnosis was that of melanoma, and detailed physical and funduscopic examinations disclosed no evidence of a primary lesion. We believe that the mass was a primary intraventricular melanoma, possibly arising from the choroid plexus, and we discuss the mechanisms that may be responsible for its occurrence in this location. (+info)Choroid plexus papilloma of cerebellopontine angle with extension to foramen magnum. (2/71)
A case of choroid plexus papilloma resembling meningioma of cerebellopontine (CP) angle with its extension to foramen magnum is presented. Occurrence of this tumour in CP angle is very rare. Its extension towards foramen magnum is further rare. It was a real diagnostic enigma preoperatively as the tumour was resembling meningioma upto some extent on radiological study. Retromastoid craniectomy with microsurgical excision of tumour and its extension was achieved in toto. Tumour was attached to few rootlets of lower cranial nerves which were preserved. Attachment of the tumour with lower cranial nerves again caused diagnostic confusion with neurofibroma intraoperatively. (+info)Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice. (3/71)
The simian virus 40 (SV40) large tumor antigen (Tag) is a virus-encoded oncoprotein which is the target of a strong cytotoxic T-lymphocyte (CTL) response. Three immunodominant H-2(b)-restricted epitopes, designated epitopes I, II/III, and IV, have been defined. We investigated whether induction of CTLs directed against these Tag epitopes might control Tag-induced tumors in SV11(+) (H-2(b)) mice. SV11(+) mice develop spontaneous tumors of the choroid plexus due to expression of SV40 Tag as a transgene. We demonstrate that SV11(+) mice are functionally tolerant to the immunodominant Tag CTL epitopes. CTLs specific for the H-2Kb-restricted Tag epitope IV were induced in SV11(+) mice following adoptive transfer with unprimed C57BL/6 spleen cells and immunization with recombinant vaccinia viruses expressing either full-length Tag or the H-2Kb-restricted epitope IV as a minigene. In addition, irradiation of SV11(+) mice prior to adoptive transfer with unprimed C57BL/6 spleen cells led to the priming of epitope IV-specific CTLs by the endogenous Tag. Induction of epitope IV-specific CTLs in SV11(+) mice by either approach correlated with increased life span and control of the choroid plexus tumor progression, indicating that CTLs specific for the immunodominant Tag epitope IV control the progressive growth of spontaneous tumors induced by this DNA virus oncogene in transgenic mice. (+info)Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. (4/71)
Tumors derived from choroid plexus epithelium are uncommon and may exhibit a wide variety of histologic patterns. They often are difficult to distinguish from metastatic carcinomas. Previous studies that addressed this issue yielded conflicting results. Recent reports have demonstrated that evaluation of coordinate expression of cytokeratin (CK) 7 and CK20 aids in distinguishing primary from metastatic lesions in a number of anatomic sites and that tumors that commonly are metastatic to the brain retain their CK7/CK20 immunophenotype in this location. We examined 35 choroid plexus tumors with a panel of antibodies to determine their CK7/CK20 immunophenotype. Tumors from 35 patients (7 male, 28 female; mean age, 25 years), including 31 choroid plexus papillomas and 4 atypical papillomas, were evaluated. All tumors were intraventricular or within the cerebellopontine angle and composed predominantly of orderly columnar epithelial cells resting on distinct fibrovascular cores. Atypical papillomas contained combinations of focal loss of architectural pattern, increased mitotic activity, necrosis, and brain parenchymal invasion. No lesion was unequivocally malignant. Twenty-six tumors (74%), including all atypical papillomas, were CK7 positive and CK20 negative. Two tumors stained with both markers, one stained with CK20 only, and six stained with neither marker. Other findings included expression of glial fibrillary acidic protein in 24 tumors, S-100 protein in 19 tumors, transthyretin in 31 tumors, Ber EP4 in 1 tumor, CAM5.2 in 33 tumors, epithelial membrane antigen in 4 tumors, and pancytokeratin in 27 tumors. Our results indicate that the majority of choroid plexus tumors have a CK7-positive/CK20-negative immunophenotype. This finding may be useful in differentiating these lesions from metastatic carcinomas that have differing CK7/CK20 profiles. (+info)IL-12 treatment of endogenously arising murine brain tumors. (5/71)
A number of recent studies have indicated that T cells can be stimulated to attack transplanted brain tumors in rodent models. As IL-12 has been shown to activate cytotoxic T cell responses, we tested the idea that it might stimulate a T cell response against endogenous brain tumors that arise in SV40 large T Ag transgenic mice (SV11). SV11 mice develop tumors of the choroid plexus, a specialization of the ependymal lining of the brain ventricles. They are a particularly relevant model of human disease, because they are immunocompetent but immunologically tolerant of the tumors. SV11 mice were treated with recombinant murine IL-12 for 10 days. Tumors grew more slowly than in control treated mice, and in some cases were reduced in size, as assessed by magnetic resonance imaging before and after treatment. At the end of treatment, tumors, but not brain parenchyma, exhibited extensive infiltration of activated CD8(+) and CD4(+) T cells. Tumors also showed a reduction in vascular density. Mice treated with IL-12 lived significantly longer than control mice. Tumors that progressed were nearly devoid of T cells, indicating that the T cell response was not sustained. In addition, some mice that had a substantial tumor burden at the beginning of treatment displayed evidence of immunosuppression, which might be related to TGF-ss2 detected in tumors. We conclude that IL-12 treatment can initiate an anti-tumor response even against endogenously arising brain tumors, but factors that will allow a sustained and more effective anti-tumor response need to be determined. (+info)Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. (6/71)
The level of prostaglandin D synthase (PGDS), a major protein constituent of cerebrospinal fluid (CSF), is altered in various brain diseases, including meningitis. However, its role in the brain remains unclear. PGDS is mainly synthesized in the arachnoid cells, the choroid plexus and oligodendrocytes in the central nervous system. Among brain tumors, meningiomas showed intense immunoreactivity to PGDS in the perinuclear region. Thus, PGDS has been considered a specific cell marker of meningioma. In this study, we examined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumors (64%) showed immunoreactivity for PGDS in the perinuclear region. For comparison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined. Meningiomas showed positive immunoreactivity for PGDS in 13 cases (80%). Except for one case located at the sacrum, none of the other soft-tissue HPCs showed immunostaining for PGDS. Mesenchymal chondrosarcoma arises in the bones of the skull, and its histological pattern resembles that of HPC; however, it showed no immunoreactivity for PGDS. Neither choroid plexus papillomas nor oligodendrogliomas were immunopositive for PGDS. These findings suggest that meningeal HPCs may have a unique molecular phenotype that is distinct from that of the soft-tissue HPCs. The origin of meningeal HPCs may be more closely related to the arachnoid cells. (+info)Tissue-specific expression of SV40 in tumors associated with the Li-Fraumeni syndrome. (7/71)
Inactivation of wild-type p53 tumor suppressor function is the primary mechanism of tumor initiation in Li-Fraumeni syndrome (LFS) individuals with germline p53 mutations. Tumors derived from LFS patients frequently retain the normal p53 allele, suggesting that alternative mechanisms in addition to gene deletion must be involved in inactivating wild-type p53 protein. DNA tumor viruses, such as SV40, target p53 for inactivation through the action of viral oncoproteins. We studied the probands from two unrelated LFS families, each of whom presented with multiple malignant neoplasms. Patient 1 developed an embryonal rhabdomyosarcoma (RMS) and a choroid plexus carcinoma (CPC), while patient 2 developed a CPC and subsequently presented with both an osteosarcoma (OS) and renal cell carcinoma (RCC). We utilized DNA sequence analysis and immunohistochemistry to determine p53 gene status in the germline and tumors, as well as evidence for SV40 T-antigen oncoprotein expression. Each patient harbored a heterozygous germline p53 mutation at codons 175 and 273, respectively. In patient 1, the normal p53 gene was lost while the mutant p53 allele was reduced to homozygosity in the RMS. Both normal and mutant genes were maintained in the CPC. In patient 2, normal and mutant p53 alleles were retained in both the CPC and RCC. Both specific PCR and immunostaining detected SV40 T-antigen in both CPCs and the RCC. In addition to chromosomal alterations, epigenetic mechanisms may disrupt p53 function during tumorigenesis. In two LFS patients, we found SV40 DNA sequences and viral T-antigen expression that could account for inactivation of the normal p53 protein. Inactivation of p53 or other tumor suppressors by viral proteins may contribute to tumor formation in specific tissues of genetically susceptible individuals. (+info)Cytogenetics and molecular genetics of childhood brain tumors. (8/71)
Considerable progress has been made toward improving survival for children with brain tumors, and yet there is still relatively little known regarding the molecular genetic events that contribute to tumor initiation or progression. Nonrandom patterns of chromosomal deletions in several types of childhood brain tumors suggest that the loss or inactivation of tumor suppressor genes are critical events in tumorigenesis. Deletions of chromosomal regions 10q, 11 and 17p, and example, are frequent events in medulloblastoma, whereas loss of a region within 22q11.2, which contains the INI1 gene, is involved in the development of atypical teratoid and rhabdoid tumors. A review of the cytogenetic and molecular genetic changes identified to date in childhood brain tumors will be presented. (+info)Choroid plexus neoplasms are rare types of brain tumors that arise from the choroid plexus, which are clusters of blood vessels in the ventricles (fluid-filled spaces) of the brain. These tumors can be benign (choroid plexus papilloma) or malignant (choroid plexus carcinoma). Choroid plexus neoplasms most commonly occur in children under the age of 2, but they can also affect adults. Symptoms may include increased head circumference, hydrocephalus (fluid buildup in the brain), vomiting, and developmental delays. Treatment typically involves surgical removal of the tumor, followed by radiation therapy or chemotherapy for malignant tumors.
The choroid plexus is a network of blood vessels and tissue located within each ventricle (fluid-filled space) of the brain. It plays a crucial role in the production of cerebrospinal fluid (CSF), which provides protection and nourishment to the brain and spinal cord.
The choroid plexus consists of modified ependymal cells, called plexus epithelial cells, that line the ventricular walls. These cells have finger-like projections called villi, which increase their surface area for efficient CSF production. The blood vessels within the choroid plexus transport nutrients, ions, and water to these epithelial cells, where they are actively secreted into the ventricles to form CSF.
In addition to its role in CSF production, the choroid plexus also acts as a barrier between the blood and the central nervous system (CNS), regulating the exchange of substances between them. This barrier function is primarily attributed to tight junctions present between the epithelial cells, which limit the paracellular movement of molecules.
Abnormalities in the choroid plexus can lead to various neurological conditions, such as hydrocephalus (excessive accumulation of CSF) or certain types of brain tumors.
A choroid plexus papilloma is a rare, benign (non-cancerous) tumor that develops in the choroid plexus, which are clusters of blood vessels and specialized cells in the ventricles of the brain. These tumors can occur at any age but are more common in children under the age of 10.
Choroid plexus papillomas arise from the ependymal cells that line the ventricular system and produce cerebrospinal fluid (CSF). The tumor grows slowly and tends to block the flow of CSF, leading to increased intracranial pressure and symptoms such as headaches, vomiting, irritability, and developmental delays in children.
The medical definition of choroid plexus papilloma is: "A benign, slow-growing tumor that arises from the ependymal cells of the choroid plexus in the ventricles of the brain. The tumor can obstruct the flow of cerebrospinal fluid and cause increased intracranial pressure."
It is important to note that while choroid plexus papillomas are generally benign, they can still cause significant symptoms due to their location in the brain and the obstruction of CSF flow. Treatment typically involves surgical removal of the tumor, followed by radiation therapy or chemotherapy if necessary.
The choroid is a layer of the eye that contains blood vessels that supply oxygen and nutrients to the outer layers of the retina. It lies between the sclera (the white, protective coat of the eye) and the retina (the light-sensitive tissue at the back of the eye). The choroid is essential for maintaining the health and function of the retina, particularly the photoreceptor cells that detect light and transmit visual signals to the brain. Damage to the choroid can lead to vision loss or impairment.
The brachial plexus is a network of nerves that originates from the spinal cord in the neck region and supplies motor and sensory innervation to the upper limb. It is formed by the ventral rami (branches) of the lower four cervical nerves (C5-C8) and the first thoracic nerve (T1). In some cases, contributions from C4 and T2 may also be included.
The brachial plexus nerves exit the intervertebral foramen, pass through the neck, and travel down the upper chest before branching out to form major peripheral nerves of the upper limb. These include the axillary, radial, musculocutaneous, median, and ulnar nerves, which further innervate specific muscles and sensory areas in the arm, forearm, and hand.
Damage to the brachial plexus can result in various neurological deficits, such as weakness or paralysis of the upper limb, numbness, or loss of sensation in the affected area, depending on the severity and location of the injury.
Cerebral ventricle neoplasms refer to tumors that develop within the cerebral ventricles, which are fluid-filled spaces in the brain. These tumors can arise from various types of cells within the ventricular system, including the ependymal cells that line the ventricles, choroid plexus cells that produce cerebrospinal fluid, or other surrounding tissues.
Cerebral ventricle neoplasms can cause a variety of symptoms depending on their size and location, such as headaches, nausea, vomiting, vision changes, imbalance, weakness, or difficulty with mental tasks. The treatment options for these tumors may include surgical resection, radiation therapy, and chemotherapy, depending on the type and extent of the tumor. Regular follow-up care is essential to monitor for recurrence and manage any long-term effects of treatment.
Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds and protects the brain and spinal cord. It acts as a shock absorber for the central nervous system and provides nutrients to the brain while removing waste products. CSF is produced by specialized cells called ependymal cells in the choroid plexus of the ventricles (fluid-filled spaces) inside the brain. From there, it circulates through the ventricular system and around the outside of the brain and spinal cord before being absorbed back into the bloodstream. CSF analysis is an important diagnostic tool for various neurological conditions, including infections, inflammation, and cancer.
The myenteric plexus, also known as Auerbach's plexus, is a component of the enteric nervous system located in the wall of the gastrointestinal tract. It is a network of nerve cells (neurons) and supporting cells (neuroglia) that lies between the inner circular layer and outer longitudinal muscle layers of the digestive system's muscularis externa.
The myenteric plexus plays a crucial role in controlling gastrointestinal motility, secretion, and blood flow, primarily through its intrinsic nerve circuits called reflex arcs. These reflex arcs regulate peristalsis (the coordinated muscle contractions that move food through the digestive tract) and segmentation (localized contractions that mix and churn the contents within a specific region of the gut).
Additionally, the myenteric plexus receives input from both the sympathetic and parasympathetic divisions of the autonomic nervous system, allowing for central nervous system regulation of gastrointestinal functions. Dysfunction in the myenteric plexus has been implicated in various gastrointestinal disorders, such as irritable bowel syndrome, achalasia, and intestinal pseudo-obstruction.
The ependyma is a type of epithelial tissue that lines the ventricular system of the brain and the central canal of the spinal cord. These cells are specialized glial cells that help to form the blood-brain barrier, regulate the cerebrospinal fluid (CSF) composition, and provide support and protection for the nervous tissue.
Ependymal cells have a cuboidal or columnar shape and possess numerous cilia on their apical surface, which helps to circulate CSF within the ventricles. They also have tight junctions that help to form the blood-brain barrier and prevent the passage of harmful substances from the blood into the CSF.
In addition to their role in maintaining the integrity of the CNS, ependymal cells can also differentiate into other types of cells, such as neurons and glial cells, under certain conditions. This property has made them a topic of interest in regenerative medicine and the study of neurodevelopmental disorders.
The submucosal plexus, also known as Meissner's plexus, is a component of the autonomic nervous system located in the submucosa layer of the gastrointestinal tract. It is a network of nerve fibers and ganglia that primarily regulates local reflexes and secretions, contributing to the control of gut motility, blood flow, and mucosal transport.
Meissner's plexus is part of the enteric nervous system (ENS), which can operate independently from the central nervous system (CNS). The ENS consists of two interconnected plexuses: Meissner's submucosal plexus and Auerbach's myenteric plexus.
Meissner's plexus is responsible for regulating functions such as absorption, secretion, vasodilation, and local immune responses in the gastrointestinal tract. Dysfunction of this plexus can lead to various gastrointestinal disorders, including irritable bowel syndrome (IBS) and other motility-related conditions.
The meninges are the protective membranes that cover the brain and spinal cord. They consist of three layers: the dura mater (the outermost, toughest layer), the arachnoid mater (middle layer), and the pia mater (the innermost, delicate layer). These membranes provide protection and support to the central nervous system, and contain blood vessels that supply nutrients and remove waste products. Inflammation or infection of the meninges is called meningitis, which can be a serious medical condition requiring prompt treatment.
Choroid neoplasms are abnormal growths that develop in the choroid, a layer of blood vessels that lies between the retina and the sclera (the white of the eye). These growths can be benign or malignant (cancerous). Benign choroid neoplasms include choroidal hemangiomas and choroidal osteomas. Malignant choroid neoplasms are typically choroidal melanomas, which are the most common primary eye tumors in adults. Other types of malignant choroid neoplasms include metastatic tumors that have spread to the eye from other parts of the body. Symptoms of choroid neoplasms can vary depending on the size and location of the growth, but may include blurred vision, floaters, or a dark spot in the visual field. Treatment options depend on the type, size, and location of the tumor, as well as the patient's overall health and personal preferences.
The Blood-Brain Barrier (BBB) is a highly specialized, selective interface between the central nervous system (CNS) and the circulating blood. It is formed by unique endothelial cells that line the brain's capillaries, along with tight junctions, astrocytic foot processes, and pericytes, which together restrict the passage of substances from the bloodstream into the CNS. This barrier serves to protect the brain from harmful agents and maintain a stable environment for proper neural function. However, it also poses a challenge in delivering therapeutics to the CNS, as most large and hydrophilic molecules cannot cross the BBB.
The celiac plexus, also known as the solar plexus or autonomic plexus, is a complex network of nerves located in the abdomen, near the stomach and other digestive organs. It plays a crucial role in regulating various automatic functions of the body, such as digestion, absorption, and secretion.
The celiac plexus is formed by the union of several splanchnic nerves that arise from the spinal cord and pass through the diaphragm to reach the abdomen. These nerves carry sensory information from the organs in the abdomen to the brain, as well as motor impulses that control the function of these organs.
In some medical procedures, such as celiac plexus block or neurolysis, the celiac plexus may be targeted to relieve chronic pain associated with conditions like pancreatitis, cancer, or abdominal surgery. These procedures involve injecting anesthetic or neurolytic agents into the area around the celiac plexus to interrupt nerve signals and reduce pain.
The lumbosacral plexus is a complex network of nerves that arises from the lower part of the spinal cord, specifically the lumbar (L1-L5) and sacral (S1-S4) roots. This plexus is responsible for providing innervation to the lower extremities, including the legs, feet, and some parts of the abdomen and pelvis.
The lumbosacral plexus can be divided into several major branches:
1. The femoral nerve: It arises from the L2-L4 roots and supplies motor innervation to the muscles in the anterior compartment of the thigh, as well as sensation to the anterior and medial aspects of the leg and thigh.
2. The obturator nerve: It originates from the L2-L4 roots and provides motor innervation to the adductor muscles of the thigh and sensation to the inner aspect of the thigh.
3. The sciatic nerve: This is the largest nerve in the body, formed by the union of the tibial and common fibular (peroneal) nerves. It arises from the L4-S3 roots and supplies motor innervation to the muscles of the lower leg and foot, as well as sensation to the posterior aspect of the leg and foot.
4. The pudendal nerve: It originates from the S2-S4 roots and is responsible for providing motor innervation to the pelvic floor muscles and sensory innervation to the genital region.
5. Other smaller nerves, such as the ilioinguinal, iliohypogastric, and genitofemoral nerves, also arise from the lumbosacral plexus and supply sensation to various regions in the lower abdomen and pelvis.
Damage or injury to the lumbosacral plexus can result in significant neurological deficits, including muscle weakness, numbness, and pain in the lower extremities.
The cervical plexus is a network of nerves that arises from the ventral rami (anterior divisions) of the first four cervical spinal nerves (C1-C4) and a portion of C5. These nerves form a series of loops and anastomoses (connections) that give rise to several major and minor branches.
The main functions of the cervical plexus include providing sensory innervation to the skin on the neck, shoulder, and back of the head, as well as supplying motor innervation to some of the muscles in the neck and shoulders, such as the sternocleidomastoid and trapezius.
Some of the major branches of the cervical plexus include:
* The lesser occipital nerve (C2), which provides sensory innervation to the skin over the back of the head and neck.
* The great auricular nerve (C2-C3), which provides sensory innervation to the skin over the ear and lower part of the face.
* The transverse cervical nerve (C2-C3), which provides sensory innervation to the skin over the anterior and lateral neck.
* The supraclavicular nerves (C3-C4), which provide sensory innervation to the skin over the shoulder and upper chest.
* The phrenic nerve (C3-C5), which supplies motor innervation to the diaphragm, the major muscle of respiration.
Overall, the cervical plexus plays a crucial role in providing sensory and motor innervation to the neck, head, and shoulders, allowing for normal movement and sensation in these areas.
A cyst is a closed sac, having a distinct membrane and division between the sac and its surrounding tissue, that contains fluid, air, or semisolid material. Cysts can occur in various parts of the body, including the skin, internal organs, and bones. They can be caused by various factors, such as infection, genetic predisposition, or blockage of a duct or gland. Some cysts may cause symptoms, such as pain or discomfort, while others may not cause any symptoms at all. Treatment for cysts depends on the type and location of the cyst, as well as whether it is causing any problems. Some cysts may go away on their own, while others may need to be drained or removed through a surgical procedure.
Choroid plexus papilloma
List of diseases (C)
Choroid plexus tumor
List of MeSH codes (C10)
Nervous tissue
Papillary tumors of the pineal region
List of diseases (P)
Papilloma
Chromatin remodeling
List of MeSH codes (C04)
WHO classification of tumours of the central nervous system
Brain tumor
Li-Fraumeni syndrome
Endolymphatic sac tumor
Cerebritis
Intracranial pressure
Syndecan 1
Index of oncology articles
Marginal zone B-cell lymphoma
International Classification of Diseases for Oncology
Pathology of Choroid Plexus Neoplasms: Overview, Etiology, Clinical Features
choroid plexus neoplasms; Choroid Plexus Tumors
Choroid plexus papilloma - Wikipedia
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Choroid plexus papilloma | Radiology Reference Article | Radiopaedia.org
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Papillary tumors of the pineal region - Wikipedia
United States Cancer Statistics: Public Information Data
Primary Central Nervous System Neoplasm (Concept Id: C0751620) - MedGen - NCBI
Cyst of the choroid plexus of the brain in newborn
Pericallosal lipoma and agenesis of corpus callosum with associated lipoma of choroid plexus: A rare case report and review of...
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Papilloma19
- Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
- This coronal T1-weighted magnetic resonance image (MRI) following contrast administration shows a homogeneously enhancing choroid plexus papilloma within the right lateral ventricle of a 1-year-old boy. (medscape.com)
- Choroid plexus papilloma, also known as papilloma of the choroid plexus, is a rare benign neuroepithelial intraventricular WHO grade I lesion found in the choroid plexus. (wikipedia.org)
- Choroid plexus papilloma occurs in the lateral ventricles of children and in the fourth ventricle of adults. (wikipedia.org)
- Up to 20% of choroid plexus papilloma patients may test positive for glial fibrillary acidic protein (GFAP). (wikipedia.org)
- Some individuals with choroid plexus papilloma have germline TP53 gene mutations, according to genetic analyses. (wikipedia.org)
- Aicardi syndrome, hypomelanosis of Ito, and 9p duplication are syndromic correlations of choroid plexus papilloma. (wikipedia.org)
- Micrograph of a choroid plexus papilloma. (wikipedia.org)
- Recent researches have shown that choroid plexus papilloma and choroid plexus cancer may be distinguished from one another using arterial spin labeling. (wikipedia.org)
- Choroid plexus papilloma (CPP) is a benign neoplasm that arises from the ventricular choroid plexus. (pediatricneurosciences.com)
- In veterinary medicine, there are not many actual reports of this type of neoplasia, therefore, the aim of this paper was to report a case of a choroid plexus papilloma in a poodle dog. (unesp.br)
- Macroscopically, the choroid plexus papilloma is a well-defi ned mass, expansive, granular to papillary, grayishwhite to red color. (unesp.br)
- The fi ndings were consistent with choroid plexus papilloma located in the fourth ventricle. (unesp.br)
- An image depicting a choroid plexus papilloma can be seen below. (naqlafshk.com)
- Imaging appearance of a fourth ventricular choroid plexus papilloma (CPP). (naqlafshk.com)
- however, morphologically the tumors appeared to be less differentiated than a choroid plexus papilloma and more differentiated than a choroid plexus carcinoma. (wikipedia.org)
- Icd 10 squamous papilloma esophagus - Icd 10 squamous papilloma esophagus How to Read the Neoplasm Table for Medical Coding Polipi de esofag Esophageal papilloma icd Papilomul esophagus Înapoi la cuprins perspectivă Oricine a papilloma esophagus icd 10 polipii de la esofag, știe că, după operație, pacientul revine la normal și devine practic sănătos. (alexandrudiaconescu.ro)
- Vaccino papilloma virus trieste sintomas que producen los oxiuros, cancer peritoneal hipec papillary urothelial neoplasm of low malignant potential immunohistochemistry. (power-tuning.ro)
- Other less frequent neurological diagnoses include syringomyelia, nonmalignancy-related hydrocephalus, tumours (including ependymoma, meningioma, astrocytoma, choroid plexus papilloma and pineal germinoma) and malformations such as Dandy-Walker and Arnold-Chiari malformations. (medscape.com)
Tumors19
- Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
- [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
- Up to 90% of choroid plexus tumors in children are papillomas, and up to 70% of all choroid plexus papillomas occur in children younger than 2 years. (medscape.com)
- Although the vast majority of choroid plexus tumors are sporadic, hereditary factors appear to play a role in the development of some choroid plexus papillomas and carcinomas. (medscape.com)
- They make up 0.4 to 0.6 percent of all intracranial neoplasms in children and are the third most prevalent congenital brain tumors after teratomas and gliomas. (wikipedia.org)
- Simian virus (SV) 40 has been linked in studies to the development of choroid plexus tumors (CPTs). (wikipedia.org)
- In people with choroid plexus tumors, complexes formed by the big T antigen and the tumor suppressor proteins p53 and pRb have been shown to develop. (wikipedia.org)
- Choroid plexus tumors are divided into three categories by the World Health Organization (2016): papillomas (grade I), atypical tumors (grade II), and carcinomas (grade III). (wikipedia.org)
- Background: Choroid plexus tumors are uncommon neoplasms derived from the neuroepithelium that covers the ventricular cavity and the central canal of the spinal cord that are characterized by papillar aspect and intraventricular growth. (unesp.br)
- After the meningiomas and gliomas, choroid plexus tumors are the third encephalic tumors in dogs. (unesp.br)
- Discussion: Choroid plexus papillomas are tumors that originate in the choroid plexus epithelium. (unesp.br)
- The clinical signs in patients with choroid plexus tumors are varied depending on the location of the tumor in the central nervous system, but may include behavioral changes, ataxia, paresis, seizures, circling, cranial nerve and proprioceptive refl exes changes. (unesp.br)
- The Surveillance and End Results (SEER) database was reviewed for population-based outcomes of choroid plexus tumors (CPTs), including choroid plexus papillomas (CPP), atypical CPPs (aCPP), and choroid plexus carcinomas (CPC). (naqlafshk.com)
- The critical diagnosis of this neoplasm is often difficult because of its similarity with other primary or secondary papillary lesions of the pineal region, including parenchymal pineal tumors, papillary ependymoma, papillary meningioma, choroid plexus papilloma, and metastatic papillary carcinoma. (wikipedia.org)
- Women are wearing in the womb children should have a complete understanding about these tumors, so do not be afraid, not to panic and not to be confused with other neoplasms that are harmful to the health of the unborn child. (vsebolezni.com)
- Brain tumors may be congenital in children younger than 3 years of age and range from benign complex lesions to highly malignant neoplasms. (medlink.com)
- The common embryonal brain tumor medulloblastoma and the rare atypical rhabdoid teratoid tumor are well-defined entities in terms of their histopathological features, immunophenotype, and genetic profiles, as are other brain tumors occurring in this age range, including choroid plexus tumors and infant gliomas, and they are discussed in separate articles. (medlink.com)
- It is the most common primary intracranial neoplasm and the most diversified in histologic patterns among all primary tumors of the CNS. (medscape.com)
- Meningiomas , as defined by the World Health Organization (WHO), are "meningothelial (arachnoid) cell neoplasms, typically attached to the inner surface of the dura mater," and these tumors fall into WHO grades I, II, and III. (medscape.com)
Papillomas10
- Irrespective of patient age, choroid plexus papillomas outnumber choroid plexus carcinomas by a 5:1 ratio. (medscape.com)
- Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
- The relationship is reversed for choroid plexus papillomas. (wikipedia.org)
- Choroid plexus papillomas are an uncommon, benign (WHO grade 1) neuroepithelial intraventricular tumor, which can occur in both the pediatric (more common) and adult population. (radiopaedia.org)
- Approximately 85% of all choroid plexus papillomas occur in children under the age of 5 years 4 . (radiopaedia.org)
- Choroid plexus papillomas are WHO grade I lesions. (radiopaedia.org)
- 2 mitoses are present per 10 high-power field) and, to a lesser degree, histological features distinguish them from atypical choroid plexus papillomas (WHO grade 2) and choroid plexus carcinomas (WHO Grade 3) 7,10 . (radiopaedia.org)
- Choroid plexus papillomas typically appear as cauliflower-like masses 4,10 . (radiopaedia.org)
- On imaging, choroid plexus papillomas are characterized by vividly enhancing masses, usually intraventricular. (radiopaedia.org)
- Choroid plexus papillomas (CPPs) are benign neoplasms of the choroid plexus, a structure made from tufts of villi within the ventricular system that produces cerebrospinal fluid (CSF). (naqlafshk.com)
Benign4
- While the vast majority of these neoplasms are benign, a small percentage can be malignant. (naqlafshk.com)
- A benign or malignant neoplasm that arises from the brain or the spinal cord. (beds.ac.uk)
- A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures. (nih.gov)
- Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)
Tumor5
- Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
- The most frequent route of choroid plexus tumor spread is via seeding of the CSF. (medscape.com)
- The tumor is neuroectodermal in origin and similar in structure to a normal choroid plexus. (wikipedia.org)
- Microscopically, this tumor resembles the choroid plexus and have arboriform and vascular stroma which is coated by a single layer of cuboidal to columnar epithelial cells. (unesp.br)
- Renal cancer icd 10, Virus del papiloma humano en mujeres cuello uterino endometrial cancer news, hpv tumor hals hrvatski jezik padezi vjezba. (alexandrudiaconescu.ro)
Carcinoma1
- If there is markedly heterogeneous contrast enhancement, a choroid plexus carcinoma should be suspected 4 . (radiopaedia.org)
Intracranial neoplasms1
- CPPs comprise about 1% of intracranial neoplasms but 2-4% in children. (naqlafshk.com)
Normal choroid plexus1
- Their appearance is very similar to normal choroid plexus 7 . (radiopaedia.org)
Carcinomas2
- Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
- Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
Papillary2
Pineal1
- 3. Whitehead M, Oh C, Raju A, Choudhri A. Physiologic Pineal Region, Choroid Plexus, and Dural Calcifications in the First Decade of Life. (radiopaedia.org)
Fourth ventricle2
- The choroid plexus is a cauliflower-like tuft of blood vessels covered by a thin layer of cuboidal epithelial cells which contain plenty of mitochondria and vacuoles and it projects into the temporal horns of the lateral ventricles, the posterior portions of the third ventricle and the roof of the fourth ventricle. (biologydiscussion.com)
- It is a congenital defect in the posterior fossa where a tongue-like projection of the cerebellum and the choroid plexus extend with an enlarged fourth ventricle into the spinal canal through the foramen magnum thereby stretching and kinking backward the upper cervical spinal cord. (biologydiscussion.com)
Lateral4
- Pericallosal lipomas may extend into either or both lateral ventricles and appearing as lipomas of choroid plexus in the absence of corpus callosum. (ghrnet.org)
- These lipomas are generally measuring greater than 2 cm in diameter, have a high incidence of corpus callosum dysgenesis and fronto-facial anomalies and can extend into the choroid plexus/lateral ventricles[4,5]. (ghrnet.org)
- In this article, I present a rare case of tubulonodular midline lipoma extending into both lateral ventricles to appear as a lipoma of choroid plexus associated with corpus callosum agenesis. (ghrnet.org)
- 1) The choroid plexuses inside the ventricles of the brain, mainly the lateral ventricles - the bulk portion of the fluid is formed here. (biologydiscussion.com)
Cysts2
- With regard to trisomy 21 or down's syndrome, the disease does not affect the formation of cysts of the choroid plexus. (vsebolezni.com)
- Computed tomography (CT) and magnetic resonance imaging (MRI) are used to differentiate between the CFC and other differential diagnoses of cysts located at the choroidal fissures including cystic neoplasm, dermoid/epidermoid cysts, and enlargement of the choroidal fissure due to focal temporal lobe atrophy. (j-epilepsy.org)
Epithelial cells1
- They may be created by epithelial cells of the choroid plexus. (wikipedia.org)
Tumours1
- Familial occurrence of tumours of the choroid plexus. (familialcancerdatabase.nl)
Vascular4
- It is also important to distinguish and not to confuse a cyst choroid plexus cyst with vascular origin, which occurs in the brain due to a stroke, aneurysm or infectious diseases. (vsebolezni.com)
- Vascular plexus are the first system which begins to form after the sixth week of pregnancy. (vsebolezni.com)
- The formation of the vascular plexus indicates favorable development of the two halves of the brain. (vsebolezni.com)
- 2 and Krawchenko and Collins, 4 2) in response to temporal lobe agenesis, resulting in forming a cyst in the subarachnoid space, 5 and 3) from invagination of the vascular mesenchyme of the primitive choroid plexus into adjacent brain picked up an outer covering of glial tissue. (j-epilepsy.org)
Vast majority1
- The vast majority of choroid plexus neoplasms arise within the ventricles. (medscape.com)
Incidence1
- The overall annual incidence of choroid plexus neoplasms for all ages is 0.3 cases per million. (medscape.com)
Cancer1
- A few notes on each cancer site and its subgroups staining techniques (e.g., glandular and diffuse neoplasms of are included in this chapter. (who.int)
Invagination1
- Intraventricular meningiomas probably arise from the meningothelial cells of the tela choroidea, where there is an arachnoidal invagination into the stromal base of the choroid plexus. (medscape.com)
Disease1
- Multiple Sclerosis and the Choroid Plexus: Emerging Concepts of Disease Immunopathophysiology. (amedeo.com)
Third ventricle4
- The third ventricle is the least common intraventricular location for choroid plexus neoplasms, irrespective of patient age. (medscape.com)
- Metastatic neoplasms may involve the third ventricle via its roof, floor, lateral wall, or choroid plexus. (medscape.com)
- Another study described a cholesterol granuloma of the choroid plexus of the third ventricle, associated with a colocalized meningioma in a cat [ 13 ]. (biomedcentral.com)
- Pure endoscopic ultrasonic removal of choroid plexus papillomas of the third ventricle: technical report of two cases. (amedeo.com)
Pediatric3
- Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
- 10. Pediatric choroid plexus neoplasms: MR, CT, and pathologic correlation. (nih.gov)
- ELZONRIS is a CD123-directed cytotoxin indicated for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and in pediatric patients 2 years and older. (nih.gov)
Majority of choroid plexus1
- The vast majority of choroid plexus neoplasms arise within the ventricles. (medscape.com)
Epithelial1
- They may be created by epithelial cells of the choroid plexus. (wikipedia.org)
Primary1
- The present study describes a case of a cholesterol granuloma of the choroid plexus without an associated primary lesion in an adult, male-neutered cat with associated clinical findings. (biomedcentral.com)
Germline1
- Stewart DR, Best AF, Williams GM et al (2019) Neoplasm risk among individuals with a pathogenic germline variant in DICER1 . (springer.com)
Intraventricular1
- Intraventricular meningiomas probably arise from the meningothelial cells of the tela choroidea, where there is an arachnoidal invagination into the stromal base of the choroid plexus. (medscape.com)
Hydrocephalus1
- Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
Metastasis1
- Many neoplasms such as gliomas or metastasis will have primarily T2 hyperintensity. (appliedradiology.com)
Cerebrospinal fluid2
- Cerebrospinal fluid is made by the choroid plexus, which is in spaces in the brain called ventricles . (cancer.org)
- Occurring in the choroids plexus that line most of the ventricular system , they can result in the overproduction of cerebrospinal fluid. (encyclopedia.com)
Diseases1
- Diseases of the cervical (and first thoracic) roots, nerve trunks, cords, and peripheral nerve components of the BRACHIAL PLEXUS. (lookformedical.com)
Spinal1
- In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon. (lookformedical.com)
Ventricular1
- 4. Lateral ventricular neoplasms of the brain: differential diagnosis based on clinical, CT, and MR findings. (nih.gov)
Neuroectodermal1
- The tumor is neuroectodermal in origin and similar in structure to a normal choroid plexus. (wikipedia.org)
Differential2
- CAPNON may mimic more common vascular malformations or neoplasms and are often not considered in the differential diagnosis of calcified lesions. (ajnr.org)
- Although plexus cholesterol granulomas are rarely seen in cats, they should be considered as a differential diagnosis in elderly patients with neurological signs such as behavioral changes. (biomedcentral.com)
Brain1
- A brain tumor is an abnormal growth of cells (neoplasm) in the skull. (encyclopedia.com)
Childhood1
- 16. Childhood choroid plexus neoplasms. (nih.gov)
Patients1
- Pancreatic cancer risk is elevated in this syndrome, and our case highlights the need for vigilance in screening for pancreatic neoplasms in these patients. (biomedcentral.com)
Syndrome1
- A syndrome associated with inflammation of the BRACHIAL PLEXUS. (lookformedical.com)