Cissampelos
Menispermaceae
Tephrosia
Cissampelos sympodialis Eichl (Menispermaceae) leaf extract induces interleukin-10-dependent inhibition of Trypanosoma cruzi killing by macrophages. (1/6)
The aqueous fraction of the ethanolic extract (AFL) of Cissampelos sympodialis Eichl (Menispermaceae), popularly known as milona, has been shown to have both immunosuppressive and anti-inflammatory effects. In the present study we investigated the modulation of macrophage antimicrobicidal activity by in vitro treatment with the extract from C. sympodialis. Normal and thioglycolate-elicited mouse peritoneal macrophages were infected in vitro with the protozoan Trypanosoma cruzi DM28c clone. We observed that the AFL (used at doses ranging from 13 to 100 microg/ml) increased T. cruzi growth and induced a 75% reduction in nitric oxide production. This inhibition could be mediated by the stimulation of macrophage interleukin-10 (IL-10) secretion since the in vitro treatment with the AFL stimulated IL-10 production by T. cruzi-infected macrophages. These results suggest that the anti-inflammatory effect of the AFL from C. sympodialis could be, at least in part, mediated by the inhibition of macrophage functions and that the inhibition of macrophage microbicidal activity induced by the C. sympodialis extract may be mediated by the decrease in macrophage function mediated by interleukin-10 production. (+info)Modulation of B lymphocyte function by an aqueous fraction of the ethanol extract of Cissampelos sympodialis Eichl (Menispermaceae). (2/6)
Cissampelos sympodialis Eichl species are used in folk medicine for the treatment of asthma, arthritis and rheumatism. In the present study, we investigated the immunomodulatory effect of an aqueous fraction of a 70% (v/v) ethanol extract of C. sympodialis leaves on B lymphocyte function. The hydroalcoholic extract inhibited the in vitro proliferative response of resting B cells induced by LPS (IC50 = 17.2 g/ml), anti-delta-dextran (IC50 = 13.9 g/ml) and anti-IgM (IC50 = 24.3 g/ml) but did not affect the anti-MHC class II antibody-stimulated proliferative response of B cell blasts obtained by stimulation with IL-4 and anti-IgM. Incubation with the hydroalcoholic extract used at 50 g/ml induced a 700% increase in intracellular cAMP levels. IgM secretion by resting B cells (obtained from normal mice) and polyclonally activated B cells (obtained from Trypanosoma cruzi-infected animals) was inhibited by the hydroalcoholic extract. The latter were more sensitive to the hydroalcoholic extract since 6.5 g/ml induced a 20% inhibition in the response of cells from normal mice while it inhibited the response of B cells from infected animals by 75%. The present data indicate that the alcoholic extract of C. sympodialis inhibited B cell function through an increase in intracellular cAMP levels. The finding that the hydroalcoholic extract inhibited immunoglobulin secretion suggests a therapeutic use for the extract from C. sympodialis in conditions associated with unregulated B cell function and enhanced immunoglobulin secretion. Finally, the inhibitory effect of the hydroalcoholic extract on B cells may indicate an anti-inflammatory effect of this extract. (+info)Larvicidal, antimicrobial and brine shrimp activities of extracts from Cissampelos mucronata and Tephrosia villosa from coast region, Tanzania. (3/6)
(+info)Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma. (4/6)
(+info)Antileishmanial activity of warifteine: a bisbenzylisoquinoline alkaloid isolated from Cissampelos sympodialis Eichl. (Menispermaceae). (5/6)
(+info)Managing murine food allergy with Cissampelos sympodialis Eichl (Menispermaceae) and its alkaloids. (6/6)
(+info)Cissampelos is a genus of climbing shrubs and vines that belong to the family Menispermaceae. It includes several species that are native to tropical regions of the Americas, Africa, and Asia. Some of these species have been used in traditional medicine for various purposes, such as treating pain, inflammation, fever, and gastrointestinal disorders. However, it is important to note that many of these uses have not been scientifically validated, and some Cissampelos species contain toxic compounds that can cause adverse effects if used improperly. Therefore, it is recommended to consult with a healthcare professional before using any Cissampelos preparations for medicinal purposes.
Menispermaceae is not a medical term, but a botanical term referring to a family of flowering plants. It includes around 70 genera and 450-550 species of woody vines, shrubs, and small trees. Some members of this family contain alkaloids and have been used in traditional medicine in various parts of the world. However, it is important to note that the use of these plants as medicine should be done under the guidance of a healthcare professional, as they can also contain toxic compounds.
Tephrosia is a genus of flowering plants in the pea family, Fabaceae. It includes several species that are native to tropical and subtropical regions around the world. Some common names for Tephrosia include wild sensitive plant, fish poison pea, and devil's shrub.
In a medical context, Tephrosia is not widely recognized or used as a treatment. However, some species of Tephrosia have been reported to have medicinal properties in traditional medicine. For example, Tephrosia purpurea has been used in Ayurvedic medicine to treat a variety of conditions, including skin diseases, inflammation, and fever. The roots and leaves of this plant contain various chemical compounds that may have therapeutic effects, such as tannins, saponins, and alkaloids.
It is important to note that the use of Tephrosia or any other herbal remedy should be done under the guidance of a qualified healthcare provider, as these substances can interact with other medications and have potential side effects. Additionally, more research is needed to confirm the safety and efficacy of Tephrosia for medical purposes.
An axenic culture is a type of laboratory culture that is free from any other living organisms, including bacteria, fungi, and viruses. This is achieved by using specific techniques to sterilize the growth medium and eliminate any contaminating microorganisms. Axenic cultures are often used in scientific research to study the pure effects of a single organism without the influence of other organisms. They are commonly used in fields such as microbiology, cell biology, and genetics.