Collagen Diseases
Caplan Syndrome
Retropharyngeal Abscess
Lung Diseases, Interstitial
Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and pulmonary fibrosis associated with collagen vascular disorders. (1/154)
BACKGROUND: It has been suggested that the humoral immune system plays a role in the pathogenesis of cryptogenic fibrosing alveolitis (CFA). Although circulating autoantibodies to lung protein(s) have been suggested, none of the lung proteins have been characterised. The purpose of this study was to determine the antigen to which the serum from patients with pulmonary fibrosis reacted. METHODS: The anti-A549 cell antibody was characterised in a patient with CFA using Western immunoblotting and immunohistochemical staining of A549 cells. As we identified that one of the antibodies against A549 cells was anti-cytokeratin 8, the expression of mRNA of cytokeratin 8 in A549 cells was evaluated. In addition, we attempted to establish an enzyme linked immunosorbent assay to measure the levels of anti-cytokeratin 8 antibody in the serum of patients with CFA and pulmonary fibrosis associated with collagen vascular disorders (PF-CVD). RESULTS: Initially two anti-A549 cell antibodies were detected in the serum of patients with pulmonary fibrosis, one of which was characterised as anticytokeratin 8 antibody by Western immunoblotting. We were able to establish an ELISA to measure anti-cytokeratin 8 antibody and found significantly higher levels in patients with CFA and PF-CVD than in normal volunteers, patients with sarcoidosis, pneumonia, and pulmonary emphysema. CONCLUSIONS: One of the anti-A549 cell antibodies in the serum of patients with CFA was against cytokeratin 8. The serum levels of anti-cytokeratin 8 antibody were increased in patients with CFA and PF-CVD. These results suggest that anticytokeratin 8 antibody may be involved in the process of lung injury in pulmonary fibrosis. (+info)Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings. (2/154)
The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and activated pericryptal fibroblasts. (+info)Elevated serum and BAL cytokeratin 19 fragment in pulmonary fibrosis and acute interstitial pneumonia. (3/154)
Cytokeratin 19 fragment (CK19) levels in serum have already been documented as a useful tumour marker for lung cancer. In the present study, it was hypothesized that CK19 may be increased in the serum and epithelial lining fluid of the respiratory tract from patients with pulmonary fibrosis. CK19 was measured in the serum and bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis and the correlation between CK19 levels and clinical parameters evaluated. Nineteen patients diagnosed with idiopathic pulmonary fibrosis (IPF), eight with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), seven patients with acute interstitial pneumonia (AIP), and 10 normal smokers as a control group were studied. CK19 levels in sera of patients with IPF and patients with PF-CVD were significantly increased compared to those of normal smokers. CK19 levels in sera of patients with AIP were significantly increased compared to those of other groups. CK19 values in the BALF of patients with pulmonary fibrosis were significantly elevated compared to those of normal smokers. CK19 values in sera charged according to the progression or improvement of the acute lung injury. Immunohistochemical study using pulmonary tissues obtained from patients with AIP demonstrated that the hyaline membrane and proliferating type II pneumocytes were stained by anti-human cytokeratin 19 antibody. These data demonstrated that the measurement of cytokeratin 19 fragment is a useful parameter to evaluate the activity of lung epithelial cell damage and repair. (+info)Collagen dysplasia (cutaneous asthenia) in a cat. (4/154)
Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen. (+info)Report of five novel and one recurrent COL2A1 mutations with analysis of genotype-phenotype correlation in patients with a lethal type II collagen disorder. (5/154)
Achondrogenesis II-hypochondrogenesis and severe spondyloepiphyseal dysplasia congenita (SEDC) are lethal forms of dwarfism caused by dominant mutations in the type II collagen gene (COL2A1). To identify the underlying defect in seven cases with this group of conditions, we used the combined strategy of cartilage protein analysis and COL2A1 mutation analysis. Overmodified type II collagen and the presence of type I collagen was found in the cartilage matrix of all seven cases. Five patients were heterozygous for a nucleotide change that predicted a glycine substitution in the triple helical domain (G313S, G517V, G571A, G910C, G943S). In all five cases, analysis of cartilage type II collagen suggested incorporation of the abnormal alpha1(II) chain in the extracellular collagen trimers. The G943S mutation has been reported previously in another unrelated patient with a strikingly similar phenotype, illustrating the possible specific effect of the mutation. The radiographically less severely affected patient was heterozygous for a 4 bp deletion in the splice donor site of intron 35, likely to result in aberrant splicing. One case was shown to be heterozygous for a single nucleotide change predicted to result in a T1191N substitution in the carboxy-propeptide of the proalpha1(II) collagen chain. Study of the clinical, radiographic, and morphological features of the seven cases supports evidence for a phenotypic continuum between achondrogenesis II-hypochondrogenesis and lethal SEDC and suggests a relationship between the amount of type I collagen in the cartilage and the severity of the phenotype. (+info)Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (6/154)
OBJECTIVE: To clarify the differences in the clinical features between idiopathic interstitial pneumonia (IIP) and interstitial pneumonia associated with collagen vascular diseases (CVD-IP). METHODS: Symptoms, radiographic findings, pulmonary function, blood chemistry data including autoantibody, and bronchoalveolar lavage fluid (BALF) findings were compared using multiple logistic regression analysis. PATIENTS: The subjects were 44 patients clinically diagnosed with IIP and 33 patients with CVD-IP. RESULTS: The clinical features related to IIP were as follows: male sex, advanced age, past history of hypertension, presence of cough, exertional dyspnea, digital clubbing, an increased level of gamma-globulin, decreased lung volume on chest X-ray, and typical type according to the criteria for IIP on chest X-ray. Increased levels of rheumatoid factor and total cell number in BALF were related to CVD-IP. CONCLUSION: These findings are considered to be useful to differentiate IIP and CVD-IP. (+info)Role of carbohydrate antigens sialyl Lewis (a) (CA19-9) in bronchoalveolar lavage in patients with pulmonary fibrosis. (7/154)
BACKGROUND: It has been reported that carbohydrate antigen sialyl Lewis (a) (CA19-9) levels are elevated in serum as well as in bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis. However, the biological significance of CA19-9 is unclear. OBJECTIVE: The purpose of the present study was to evaluate correlations between CA19-9 levels in BALF and several biochemical as well as clinical parameters in patients with pulmonary fibrosis. In addition, biological functions of CA19-9 were also examined. METHODS: We studied 24 patients with a diagnosis of pulmonary fibrosis: 16 with idiopathic pulmonary fibrosis (IPF) and 8 with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD). In BALF, carbohydrate antigens sialyl Lewis (a) (CA19-9), elastase: alpha(1)-proteinase inhibitor complex (E-PI), hepatocyte growth factor (HGF), LDH, IgG, IgA, albumin, and cell differentiation were measured. We also evaluated the effects of CA19-9 on neutrophil functions. RESULTS: CA19-9/albumin levels in BALF significantly correlated with HGF/albumin, elastase/albumin, LDH/albumin, total number of alveolar macrophages, and total number of neutrophils. Purified CA19-9 had a chemotactic activity for neutrophils. In addition, neutrophil chemotactic activity to C5a, fMLP, and interleukin 8 was significantly stimulated after incubation with purified CA19-9. Furthermore, CA19-9 increased the expression of CD15s on neutrophils. CONCLUSIONS: Our data demonstrated (i) CA19-9 in BALF correlated with other markers of inflammation in pulmonary fibrosis, and (ii) CA19-9 can modify neutrophil functions. These results suggest that CA19-9 may play a role in the process of lung injury in patients with pulmonary fibrosis. (+info)Alternate-day prednisone therapy and human lymphocyte subpopulations. (8/154)
The mechanisms and kinetics of the immunosuppressive effects of alternate-day prednisone were investigated in a group of patients with a variety of inflammatory diseases receiving a range of alternate-day prednisone doses from 5 to 120 mg. Total circulating lymphocyte and monocyte counts, as well as proportions of lymphocyte subpopulations defined both by surface markers and by in vitro functional capacities, were studied. At 8 a. m. of the day on prednisone, just before drug administration, lymphocyte and monocyte counts, proportions of lymphocyte subpopulations, as well as in vitro lymphocyte blastogenic responses to various mitogenic and antigenic stimuli were normal. 4 h after the administration of prednisone, there was a profound lymphocytopenia and monocytopenia, with a differential depletion of thymus-derived lymphocytes as well as various functionally defined lymphocyte subpopulations. Lymphocyte kinetic studies using a radioactive chromium-labeled autologous lymphocytes showed that the lymphocytopenia was due predominantly to a transient depletion of the recirculating portion of the intravascular lymphocytepool. All these parameters returned to normal by 8 a.m. of the following day (off prednisone) and remained normal throughout the day. This very transient lymphocytopenia and monocytopenia after prednisone, with normal cell numbers, proportions, and functions throughout the remainder of the 2-day cycle, was associated with suppression of disease activity, yet did not affect cutaneous delayed hypersensitivity in these patients nor increase the likelihood of infectious complications. This drug-associated cyclic and transient monocytopenia and selective lymphocytopenia is best explained by a redistribution of recirculating lymphocytes to other body compartments, particularly the bone marrow. (+info)Collagen diseases, also known as collagen disorders or connective tissue diseases, refer to a group of medical conditions that affect the body's connective tissues. These tissues provide support and structure for various organs and systems in the body, including the skin, joints, muscles, and blood vessels.
Collagen is a major component of connective tissues, and it plays a crucial role in maintaining their strength and elasticity. In collagen diseases, the body's immune system mistakenly attacks healthy collagen, leading to inflammation, pain, and damage to the affected tissues.
There are several types of collagen diseases, including:
1. Systemic Lupus Erythematosus (SLE): This is a chronic autoimmune disease that can affect various organs and systems in the body, including the skin, joints, kidneys, heart, and lungs.
2. Rheumatoid Arthritis (RA): This is a chronic inflammatory disease that primarily affects the joints, causing pain, swelling, and stiffness.
3. Scleroderma: This is a rare autoimmune disorder that causes thickening and hardening of the skin and connective tissues, leading to restricted movement and organ damage.
4. Dermatomyositis: This is an inflammatory muscle disease that can also affect the skin, causing rashes and weakness.
5. Mixed Connective Tissue Disease (MCTD): This is a rare autoimmune disorder that combines symptoms of several collagen diseases, including SLE, RA, scleroderma, and dermatomyositis.
The exact cause of collagen diseases is not fully understood, but they are believed to be related to genetic, environmental, and hormonal factors. Treatment typically involves a combination of medications, lifestyle changes, and physical therapy to manage symptoms and prevent complications.
Caplan syndrome, also known as Caplan's syndrome or pneumoconiosis with rheumatoid nodules, is a rare condition characterized by the presence of multiple round, well-circumscribed nodules in the lungs. These nodules are similar to those seen in rheumatoid arthritis and are typically found in individuals who have been exposed to coal dust or other types of mineral dust.
The syndrome was first described in 1953 by Dr. Anthony Caplan, a Welsh physician who observed the association between pneumoconiosis (a lung disease caused by inhaling mineral dust) and rheumatoid nodules in coal miners. The condition is most commonly seen in coal miners, but it has also been reported in other occupations with exposure to mineral dust, such as stone cutters and sandblasters.
Caplan syndrome is thought to occur when the immune system's response to mineral dust exposure triggers an inflammatory reaction that leads to the formation of rheumatoid nodules in the lungs. The presence of these nodules can cause symptoms such as cough, shortness of breath, and chest pain. In severe cases, Caplan syndrome can lead to lung scarring and decreased lung function.
Diagnosis of Caplan syndrome typically involves a combination of medical history, physical examination, imaging studies (such as chest X-rays or CT scans), and laboratory tests (such as blood tests for rheumatoid arthritis). Treatment may include medications to manage the symptoms of rheumatoid arthritis and reduce inflammation in the lungs. In some cases, surgery may be necessary to remove severely damaged lung tissue.
A retropharyngeal abscess is a deep neck infection involving the potential space between the buccopharyngeal fascia and the alar fascia, primarily located in the retropharyngeal space. This space extends from the base of the skull to the mediastinum and contains loose connective tissue, fat, and lymph nodes. The infection usually originates from an upper respiratory tract infection or a penetrating injury to the posterior pharyngeal wall.
The abscess can cause swelling and compression of surrounding structures, leading to potentially serious complications such as airway obstruction, mediastinitis, or sepsis if left untreated. Symptoms may include neck pain, difficulty swallowing, fever, drooling, and decreased appetite. Diagnosis is typically made through a combination of clinical examination, imaging studies (such as CT or MRI scans), and laboratory tests. Treatment usually involves surgical drainage of the abscess and antibiotic therapy to manage the infection.
Interstitial lung diseases (ILDs) are a group of disorders characterized by inflammation and scarring (fibrosis) in the interstitium, the tissue and space around the air sacs (alveoli) of the lungs. The interstitium is where the blood vessels that deliver oxygen to the lungs are located. ILDs can be caused by a variety of factors, including environmental exposures, medications, connective tissue diseases, and autoimmune disorders.
The scarring and inflammation in ILDs can make it difficult for the lungs to expand and contract normally, leading to symptoms such as shortness of breath, cough, and fatigue. The scarring can also make it harder for oxygen to move from the air sacs into the bloodstream.
There are many different types of ILDs, including:
* Idiopathic pulmonary fibrosis (IPF): a type of ILD that is caused by unknown factors and tends to progress rapidly
* Hypersensitivity pneumonitis: an ILD that is caused by an allergic reaction to inhaled substances, such as mold or bird droppings
* Connective tissue diseases: ILDs can be a complication of conditions such as rheumatoid arthritis and scleroderma
* Sarcoidosis: an inflammatory disorder that can affect multiple organs, including the lungs
* Asbestosis: an ILD caused by exposure to asbestos fibers
Treatment for ILDs depends on the specific type of disease and its underlying cause. Some treatments may include corticosteroids, immunosuppressive medications, and oxygen therapy. In some cases, a lung transplant may be necessary.
Collagen is the most abundant protein in the human body, and it is a major component of connective tissues such as tendons, ligaments, skin, and bones. Collagen provides structure and strength to these tissues and helps them to withstand stretching and tension. It is made up of long chains of amino acids, primarily glycine, proline, and hydroxyproline, which are arranged in a triple helix structure. There are at least 16 different types of collagen found in the body, each with slightly different structures and functions. Collagen is important for maintaining the integrity and health of tissues throughout the body, and it has been studied for its potential therapeutic uses in various medical conditions.
Collagen disease
Collagen, type IV, alpha 4
Collagen, type IV, alpha 3
Collagen loss
Collagen, type VII, alpha 1
Lysine
Intestinal pseudo-obstruction
Robert Ira Lewy
Connective tissue disease
Dear Sister
Collagen
GPR56
Adhesion G protein-coupled receptor
Myocardial infarction diagnosis
Jean Baum
Cenderitide
Shangri-La (novel)
Osteogenesis imperfecta
Vitamin C
Wheat allergy
Brain healing
Eosinophil
Couvelaire uterus
Osteoblast
Scleromyositis
Epidermolysis bullosa
Anterior spinal artery syndrome
LASIK
Oligohydramnios
Relaxin
Collagen disease - Wikipedia
Collagen vascular disease: MedlinePlus Medical Encyclopedia
Collagen | Protein Folding and Human Disease | Biology | MIT OpenCourseWare
Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic...
What are the symptoms of collagen vascular disease? - Kyoto2.org
Clinical and subclinical alveolitis in collagen vascular diseases: contribution of alpha 2-macroglobulin levels in BAL fluid |...
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in...
Rice University lab encodes collagen - Program defines stable sequences for synthesis, could help fight disease, design drugs
Figures and data in Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion |...
AID 1634582 - Therapeutic anti-inflammatory activity in mouse model of collagen-induced arthritis disease assessed as effect on...
collagen disease - Siteman Cancer Center
Collagen Vascular Disease Basics and Symptoms - Fibromyalgia Women
Collagen Vascular Disease/EDS | Center for Continuing Medical Education
Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease | BMC...
CME Activity | Collagen Vascular Disease Associated With Interstitial Lung | MDs & PAs
Dilated Cardiomyopathy: Practice Essentials, Background, Pathophysiology
Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis...
Collagen Disease Antibody Panel Cost in Delhi Test Price Near Me, India | GDIC
Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. - Immunology
Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease<...
Cell-Based Collagen Company Looks To Disrupt Traditional Supply Chains For A Better World
2023 Collagen (GRS) Seminar GRC
Frontiers | Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis
Lifeboat Foundation News Blog - Page 9191
Pediatric Asthma Differential Diagnoses
Gale eBooks | Human Diseases and Conditions
Abdominal Examination: Overview, Preparation, Technique
Mixed Connective Tissue Disease: Symptoms, Causes, and Treatment
Vascular Diseases10
- Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic interstitial pneumonia? (nih.gov)
- Thirteen patients (19%) subsequently developed systemic manifestations of collagen vascular diseases (CVD) and were diagnosed as having had interstitial pneumonia as the sole presentation of CVD (CVD-IP). (nih.gov)
- Collagen vascular diseases are autoimmune diseases that occur when the body's immune system attacks its own skin, tissues and organs. (kyoto2.org)
- The probability that patients with collagen vascular diseases (CVD) will develop fibrosis is unpredictable. (ersjournals.com)
- 1. Describe the main clinical features associated with Collagen Vascular Diseases/EDS. (uchicago.edu)
- 2. Gain insight into the pthophysiology of Collagen Vascular Diseases/EDS. (uchicago.edu)
- 3. Discuss treatment modalities for Collagen Vascular Diseases/EDS. (uchicago.edu)
- Identify the collagen vascular diseases and their associated interstitial lung diseases. (statpearls.com)
- Collagen Vascular Diseases. (gale.com)
- Autoimmune and collagen vascular diseases such as rheumatoid arthritis, systemic lupus erythematosus without renal disease, autoimmune hepatitis, hemolytic anemia, and endocrinopathies have been described. (lu.se)
Extracellular matrix3
- Disruption of any of the proteins involved in these biosynthesis steps potentially result in a variety of connective tissue diseases because of a destabilized extracellular matrix. (rug.nl)
- In the extracellular matrix, type VI collagen interacts with other components, including collagen type I, collagen type II and collagen type XIV (TAGLIAVINI et al. (bvsalud.org)
- Formation of H. pylori cell surface-bound plasmin may be important to provide a powerful proteolytic mechanism for gastric tissue penetration in type B gastritis and peptic ulcer disease, since plasmin degrades not only fibrin but also extracellular matrix proteins such as various collagens and fibronectin. (lu.se)
Autoimmune diseases5
- Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue. (wikipedia.org)
- Collagen vascular disease, also known as connective tissue disease, is a group of autoimmune diseases that attack the connective tissues in the body that hold muscles, ligaments, and bones together. (kyoto2.org)
- The ironic feature of autoimmune diseases is the host's immune system causes tissue injury. (ganeshdiagnostic.com)
- In Autoimmune diseases, these antibodies work against the immune response and attack the body's healthy tissues. (ganeshdiagnostic.com)
- They may also order tests to look for the presence of antibodies more closely associated with other autoimmune diseases to ensure an accurate diagnosis and/or confirm an overlap syndrome. (healthline.com)
Fibrous2
- Rice scientists who have learned how to make collagen - the fibrous protein that binds cells together into organs and tissues - are now digging into its molecular structure to see how it forms and interacts with biological systems. (analytica-world.com)
- Collagens are fibrous extracellular matrices that are present in abundance in the human body. (ganeshdiagnostic.com)
Patients with collagen2
- And here we can provide a one-stop shopping experience for patients with collagen vascular disease to get all of the treatments they need from all of the involved specialties. (fibromyalgiawomen.com)
- Outline the importance of collaboration among the interprofessional team to improve outcomes for patients with collagen vascular disease-associated interstitial lung disease. (statpearls.com)
Types of colla1
- This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen vascular disease, and the aggregates derived from them as distinct entities. (fibromyalgiawomen.com)
Arthritis16
- A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue. (wustl.edu)
- Historically, a heterogeneous group of acute and chronic diseases including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis etc. (fibromyalgiawomen.com)
- Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and bone destruction at the joints, causing pain and motor disturbance. (biomedcentral.com)
- Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. (ox.ac.uk)
- Maintenance of the invasive pannus in rheumatoid arthritis is an integral part of disease progression. (ox.ac.uk)
- Our objective in this study was to measure the kinetics of VEGF production in a murine model of collagen-induced arthritis and to determine whether VEGF blockade reduces disease progression. (ox.ac.uk)
- Synovial cells isolated from the knee joints of naive or sham-immunized mice, or from mice immunized with collagen but without arthritis, released little or no detectable VEGF. (ox.ac.uk)
- The levels of VEGF secreted by synovial cells isolated from the joints of mice with severe arthritis were significantly higher than from mice with mild disease. (ox.ac.uk)
- Our data demonstrate that, in collagen-induced arthritis, expression of the potent angiogenic cytokine VEGF correlates with disease severity. (ox.ac.uk)
- Among immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies, particularly in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. (frontiersin.org)
- Furthermore, CB treatment in a mouse model of collagen-induce arthritis resulted in a significant decrease in circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, leading to a reduction in disease progression. (frontiersin.org)
- The finding of this regulatory system provides a molecular view of the potential role of physical forces at work in heart disease, cancer, arthritis, and other disease-related processes, they say. (lifeboat.com)
- Introduction Arthritis rheumatoid (RA) can be an immune-mediated disease that impacts synovial membranes articular cartilage and bone tissue. (cancer-pictures.org)
- The enthusiasm for collagen is now being more actively tapped for the arthritis market - perhaps it's a way to drive demand among all ages. (sciencebasedmedicine.org)
- CTD associated with ILD include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis and dermatomyositis (PM/DM), Sjögren's syndrome, and mixed connective tissue disease (MCTD) 4 . (jrheum.org)
- Combined repetitive inhalant endotoxin and collagen-induced arthritis drives inflammatory lung disease and arthritis severity in a testosterone-dependent manner. (cdc.gov)
Release of collagen2
- Local inflammation in axial spondyloarthritis (axSpA) leads to the release of collagen metabolites from the disease-affected tissue. (nordicbioscience.com)
- Stage 2 progresses to erosion of the cartilage and a release of collagen fragments. (sciencebasedmedicine.org)
Heterogeneous group2
- Interstitial lung disease (ILD) represents a heterogeneous group of diseases that involves inflammation and interstitial fibrosis of the lung parenchyma. (jrheum.org)
- A heterogeneous group of autosomally inherited COLLAGEN DISEASES caused by defects in the synthesis or structure of FIBRILLAR COLLAGEN. (bvsalud.org)
20232
- The focus of the 2023 Collagen GRS is to highlight interdisciplinary topics in collagen research related, but not limited to, the broad range of physiological processes collagens are involved in and how this knowledge can aid in our understanding of collagen molecular properties, and the development of novel treatments and therapies. (grc.org)
- All attendees of the 2023 Collagen GRS are encouraged to attend the subsequent 2023 Gordon Research Conference (GRC) on Collagen. (grc.org)
Different collagen2
- Different animals produce different collagen, from humans to pigs to jellyfish. (forbes.com)
- There is an abundance of different collagen supplements with different collagen types, sources, and formulations. (healthnews.com)
Immunologically mediated2
- Collagen vascular disease-associated interstitial lung disease (CVD-ILD) consists of several immunologically mediated diseases with characteristic pulmonary features. (statpearls.com)
- Are they of value in immunologically-mediated collagen vascular disease? (aad.org)
Centers for Disea4
- Centers for Disease Control and Prevention. (cdc.gov)
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
Symptoms6
- What are the symptoms of collagen vascular disease? (kyoto2.org)
- Michael Go, MD, a vascular surgeon explains the basics of the collagen vascular disease, including common symptoms. (fibromyalgiawomen.com)
- Certolizumab is used to treat the symptoms of Crohn's disease after other treatments have failed. (everydayhealth.com)
- ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries, symptoms and conditions. (icd9data.com)
- Bowel tolerance doses of ascorbic acid ameliorate the acute symptoms of many diseases. (doctoryourself.com)
- Lesser doses often have little effect on acute symptoms but assist the body in handling the stress of disease and may reduce the morbidity of the disease. (doctoryourself.com)
Tendons4
- Low collagen levels stiffen tendons and ligaments,which means you lose flexibility and can not move as easily. (kyoto2.org)
- In the NIH study, the scientists isolated individual, nano-sized collagen fibrils from rat-tail tendons. (lifeboat.com)
- In the presence of tension, such as when tendons stretch, defects are likely eliminated, preventing enzymes from breaking down collagen that is loaded by physical force, the researchers suggest. (lifeboat.com)
- Collagen is the major component of connective tissue in the body - it's about a quarter of our body mass, and is found in skin, muscle, tendons, etc. (sciencebasedmedicine.org)
Diagnosis1
- Assessment of the stage of liver disease is important for diagnosis, treatment, and follow-up both during treatment and after cessation of treatment. (hindawi.com)
Proteins5
- A program developed at Rice University details stable forms of collagen proteins for synthesis in the lab. (analytica-world.com)
- While scientists have made a great deal of progress defining the structures of other proteins, "only a small group of us have been interested in collagen. (analytica-world.com)
- Versatile, animal-derived proteins like collagen and gelatin are common-place in packaged foods, cosmetics, and even pharmaceuticals. (forbes.com)
- This sense of urgency is also why Michelsen and Hesp have decided on a cell-based approach rather than expressing collagen proteins through microbes or cell-free technology. (forbes.com)
- The GRS brings together early career researchers involved in diverse areas of collagen research and provides a supportive and stimulating environment to share and discuss emerging research on collagen proteins. (grc.org)
Prolyl1
- Gjaltema, RAF & Bank, RA 2017, ' Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease ', Critical reviews in biochemistry and molecular biology , vol. 52, nr. 1, blz. (rug.nl)
Fibrils3
- Formation of mature collagen fibrils out of procollagen -chains requires a variety of enzymes and chaperones in a complex process spanning both intracellular and extracellular post-translational modifications. (rug.nl)
- They then exposed the collagen fibrils to fluorescently-labeled human MMP enzymes. (lifeboat.com)
- These observations revealed collagen fibrils have defects that spontaneously form and heal. (lifeboat.com)
Fibrosis5
- Chronic liver disease progresses through different pathological stages that vary from mild hepatic inflammation without fibrosis to advanced hepatic fibrosis and cirrhosis [ 6 - 8 ]. (hindawi.com)
- The rapid development of new medications for the treatment of some liver diseases, such as CHB, CHC, and nonalcoholic fatty liver disease (NAFLD), increases the requirement for more frequent evaluation of liver fibrosis to assess treatment response. (hindawi.com)
- The ideal NIM for assessing hepatic fibrosis must be simple, readily available, reliable, inexpensive, safe, and well validated in different forms of chronic liver disease. (hindawi.com)
- To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)
- The most common types of ILD include idiopathic pulmonary fibrosis (IPF) and connective tissue disease (CTD)-associated ILD (CTD-ILD). (jrheum.org)
Inflammatory4
- Additionally, we administered daily intraperitoneal CB treatment to arthritic mice to evaluate its effects on circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, as indicators of disease progression. (frontiersin.org)
- First-line agents such as nonsteroidal anti-inflammatory agents can be used initially, but some patients may require more advanced treatment with the antimalarial drug hydroxychloroquine ( Plaquenil ) or other disease-modifying agents and biologics. (healthline.com)
- RA is set up and preserved by interacting cascades of proinflammatory cytokines [1 2 TNFα and IL-1 are fundamental mediators of irritation in sufferers with inflammatory joint disease [3-6]. (cancer-pictures.org)
- While inhibition of IL-1 or TNFα produces significant anti-inflammatory results in rats with adjuvant-induced joint disease (AIA) [10 15 16 and in individual joint disease [17-19] focal bone tissue erosions in affected joint parts and systemic bone tissue loss aren't fully avoided. (cancer-pictures.org)
Symptomatic2
- So the most common and earliest stage of symptomatic lower extremity collagen vascular disease is what we call claudication. (fibromyalgiawomen.com)
- Ablation therapy may be superior to antiarrhythmics in selected patients, including those with paroxysmal atrial fibrillation who are symptomatic but without structural heart disease, patients who are intolerant of antiarrhythmics, and patients with inadequate pharmacologic rhythm control. (aafp.org)
Disorders4
- In a class of diseases known as autoimmune disorders , the body's immune system attacks its own tissues. (medlineplus.gov)
- People who developed these disorders were previously said to have "connective tissue" or "collagen vascular" disease. (medlineplus.gov)
- What are collagen vascular disorders? (kyoto2.org)
- The topics covered include infectious diseases, many cancers, chronic and acute physical and psychological conditions, newly emerging and reemerging diseases, public health issues, and issues of interest to the young adult audience (eating disorders, sports injuries, growth, and puberty). (gale.com)
Health and dis1
- Offering in-depth coverage of all areas of health and disease, Human Diseases and Conditions , 3rd ed. offers current and accurate information on approximately 450 diseases and conditions. (gale.com)
Describe1
- Describe and correlate the radiologic and pathologic features of collagen vascular disease-associated interstitial lung disease. (statpearls.com)
Genetic and Rare Diseases Information Center1
- According to the Genetic and Rare Diseases Information Center (GARD), women are three times more likely than men to develop the condition. (healthline.com)
Serum2
- The consequences of anti-IL-1 therapy on serum RANKL haven't been previously analyzed in joint disease settings and had been therefore a concentrate of the existing study. (cancer-pictures.org)
- Serum levels of collagen metabolites were significantly higher in AS and nr-axSpA than in controls. (nordicbioscience.com)
Defects1
- Some causes of atrial disease resulting in a prolonged PR interval include endocardial cushion defects and Ebstein anomaly. (medscape.com)
Pulmonary3
- Since changes in bronchoalveolar lavage (BAL) cell data can be observed in CVD patients without evidence of lung involvement, we investigated whether the study of soluble components in BAL could help to distinguish CVD patients with lung involvement (n = 15) from those without pulmonary disease (n = 37). (ersjournals.com)
- In contrast, the BAL alpha 2-MA levels were found to be normal in CVD patients without evidence of pulmonary disease as well as in CVD patients with overt lung involvement treated with steroids. (ersjournals.com)
- Chronic Obstructive Pulmonary Disease (COPD). (gale.com)
Chronic diseases1
- Learn how our biomarkers can be utilized in a wide range of chronic diseases. (nordicbioscience.com)
Subclinical1
- Herein we investigated the hypothesis that some of these AGEs (fluorescence to be reported elsewhere) correlate with long-term subclinical cardiovascular disease (CVD) measurements, i.e. coronary artery calcium score (CAC) at EDIC year 7-9 (n = 187), change of carotid intima-media thickness (IMT) from EDIC year 1 to year 6 and 12 (n = 127), and cardiac MRI outcomes at EDIC year 15-16 (n = 142). (sens.org)
Renal disease1
- Newer oral anticoagulants have a slightly lower risk of intracranial hemorrhage compared with warfarin (Coumadin), but dose adjustment is required in patients with renal disease. (aafp.org)
Clinical4
- Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes. (sens.org)
- Skin collagen AGE measurements obtained from stored specimens were related to clinical data from the DCCT/EDIC using Spearman correlations and multivariable logistic regression analyses. (sens.org)
- Recent advances in disease-modifying anti-rheumatic drugs, including the advent of biological agents and JAK inhibitors, enable now clinical remission even in previously intractable cases of RA. (biomedcentral.com)
- Clinical manifestations of chronic GVHD are similar to autoimmune collagen vascular disease and the two main types of cutaneous chronic GVHD are lichenoid and sclerodermatous. (bvsalud.org)
Joints9
- Skin Joints Bone Hydrolysed Marine Collagen Supplement Pills.Hyaluronic Acid Magnesium Vitamin C. Anti-Aging. (kyoto2.org)
- Since this disease can affect various organs such as skin, muscle, the digestive system and lungs, as well as your joints, treatment is targeted to manage the major areas of involvement. (healthline.com)
- Why collagen, and what does it have to do with our joints? (sciencebasedmedicine.org)
- Collagen is the most abundant protein found in joints. (healthnews.com)
- For this reason, some people are wondering if collagen supplementation could be beneficial in supporting joints. (healthnews.com)
- However, if you decide to try collagen for joints, it may be a challenge to find the right supplement. (healthnews.com)
- To help you choose the most suitable product, we crafted a list of what we believe are the best collagen for joints. (healthnews.com)
- Choosing the best collagen supplement for joints is a challenging task. (healthnews.com)
- To help you choose, we curated a list of the best collagen supplements for joints that are, in our opinion, worth considering. (healthnews.com)
Ulcerative2
- This has occurred mainly in teenagers and young men with Crohn's disease or ulcerative colitis. (everydayhealth.com)
- Other gastrointestinal diseases, such as spruelike syndrome, ulcerative colitis, and Crohn disease may occur. (lu.se)
Protein9
- Their success, reported in Nature Communications, will be of interest to physicians and scientists who work in reconstructive surgery, cosmetics and tissue engineering as well as to researchers investigating collagen protein interactions that could lead to new treatments for cancer and other diseases. (analytica-world.com)
- Collagen is an odd protein. (analytica-world.com)
- On one hand, it's the most abundant protein in the human body," said Hartgerink, who in a previous work unveiled a new way to synthesize self-assembling collagen. (analytica-world.com)
- By mass, collagen is the most common protein there is. (analytica-world.com)
- In the same way three-color images must be properly aligned for a viewer to see a complete picture, the three strands of a collagen protein must be in register for the protein to carry out its function. (analytica-world.com)
- Hesp, who also serves at the company's Head of Science, says there's little point in developing an alternative to collagen protein. (forbes.com)
- Collagen is a very complex protein and the founders don't want to spend extra time engineering other systems to do what cells do naturally. (forbes.com)
- WHAT: Scientists at the National Institutes of Health are reporting new, unexpected details about the fundamental structure of collagen, the most abundant protein in the human body. (lifeboat.com)
- The type VI collagen is an extracellular protein forming a distinct myofibrillar network of most interstitial connective tissues, existing in the cellular matrices of muscle, skin, tendon, cartilage, intervertebral discs, blood vessels and eyes. (bvsalud.org)
Supplements6
- Collagen supplements have been around for years, and their traditional popularity has been its purported effects on skin and nails. (sciencebasedmedicine.org)
- The difficulty arises from the fact that some collagen supplements are designed to address different concerns (such as skin health) rather than joint issues. (healthnews.com)
- There are plenty of collagen supplements on the market. (healthnews.com)
- Both of these collagen types have been studied clinically and have shown positive results making them a great choice amongst joint supplements. (healthnews.com)
- If you lean towards gummy supplements, A Quality Life offers excellent collagen gummies for joint health. (healthnews.com)
- This supplement also contains a modest amount of vitamin C. Vitamin C is needed for collagen production, and thus is often included in supplements to boost its biosynthesis. (healthnews.com)
Blood vessels1
- It's the same process as heart disease, just different blood vessels in the body. (fibromyalgiawomen.com)
Tissues3
- Collagen disease is the name of a cluster of diseases that affect the body's connective tissues. (ganeshdiagnostic.com)
- However, if doses of ascorbate are not provided to satisfy this potential draw on the nutrient, first local tissues involved in the disease, then the blood, and then the body in general become deplete of ascorbate (ANASCORBEMIA and ACUTE INDUCED SCURVY). (doctoryourself.com)
- The deficit of ascorbate probably starts in the tissues directly involved in the disease and then spreads to other tissues of the body. (doctoryourself.com)
Humans1
- Irwin Stone (10, 11, 12) pointed out the potential of vitamin C in the treatment of many diseases, the inability of humans to synthesize ascorbate, and the resultant condition hypoascorbemia. (doctoryourself.com)
Rheumatic3
- citation needed] The term "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the cause for rheumatic fever. (wikipedia.org)
- These are called undifferentiated systemic rheumatic (connective tissue) diseases or overlap syndromes. (medlineplus.gov)
- Despite the better control of inflammation and joint deformity afforded by modern disease-modifying anti-rheumatic drugs, many patients with RA remain dissatisfied with their treatment, primarily because of sensory-emotional distress. (biomedcentral.com)
Congenital1
- Bethlem myopathy (BM) and Ullrich Congenital Muscular Dystrophy (DMCU) result from a mutation in collagen type VI. (bvsalud.org)
Connective-tissue8
- Collagenopathy, types II and XI Connective tissue disease Coburn, Alvin (1974). (wikipedia.org)
- What does connective tissue disease feel like? (kyoto2.org)
- Early indications of mixed connective tissue disease can include: General feeling of being unwell. (kyoto2.org)
- What doctor treats connective tissue disease? (kyoto2.org)
- Doctors who treat patients with mixed connective tissue disease include primary-care providers such as general practitioners, internists, and family medicine doctors. (kyoto2.org)
- How do you test for connective tissue disease? (kyoto2.org)
- Routine screening tests for undifferentiated connective-tissue disease (UCTD) should include the following: Complete blood count. (kyoto2.org)
- Mixed connective tissue disease (MCTD) is a rare autoimmune disorder. (healthline.com)
Treatments3
- In a development that could lead to better drug design and new treatments for disease, Rice University researchers have made a major step toward synthesizing custom collagen. (analytica-world.com)
- Medical records research - uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best. (mayo.edu)
- Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. (mayo.edu)
Manifestations1
- These pathological manifestations dramatically diminish the quality of life in patients with RA primarily as a result of motor disturbance as well as the pain associated with the disease. (biomedcentral.com)
Processes1
- Scientists have known for years that collagen remodeling plays an important role in a wide variety of biological processes ranging from wound healing to cancer growth. (lifeboat.com)
Cyst1
- MT1-MMP induces cell proliferation and cyst growth in 3D collagen I gel culture. (biomedcentral.com)
Alzheimer's Disease1
- Alzheimer's Disease. (gale.com)
Liver diseases1
- Chronic liver diseases of differing etiologies are among the leading causes of mortality and morbidity worldwide. (hindawi.com)
Structural3
- Hartgerink likened collagen to DNA with a structural twist, as it has not two but three intertwining peptide strands. (analytica-world.com)
- Collagen is a macromolecule that has versatile roles in physiology, ranging from structural support to mediating cell signaling. (rug.nl)
- Their CAL-101 (GS-1101) central importance is certainly demonstrated by the power of anti-TNFα and anti-IL-1 therapies to markedly decrease scientific and structural procedures of disease in arthritic sufferers [7 8 and in pets with induced joint disease [9-14]. (cancer-pictures.org)
Researchers2
- The Collagen GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. (grc.org)
- In particular, researchers know that collagen is broken down by a certain class of enzymes called matrix metalloproteinases (MMPs), but exactly how they did this remained somewhat of a mystery, until now. (lifeboat.com)
Maladies2
- A noteworthy group of maladies of unknown origin which primarily involve connective tissue has been termed collagen diseases. (kyoto2.org)
- Examples of maladies causing secondary achalasia include certain malignancies, diabetes mellitus, and Chagas disease. (medscape.com)
Coronary artery1
- Coronary artery disease is a factor. (medscape.com)
Type5
- What is type 1 collagen? (kyoto2.org)
- Type 1 collagen is gram-for-gram stronger than steel. (forbes.com)
- We ranked products that contain intact type II collagen or hydrolyzed collagen higher because these collagens were studied the most for joint health. (healthnews.com)
- Moreover, this product contains 40 mg of intact type II collagen, which aligns with the dosage used in several studies on this type of collagen that yielded favorable outcomes for joint health. (healthnews.com)
- However, the manufacturer does not identify the type of collagen used to make these gummies. (healthnews.com)
Functions1
- To perform its many functions, collagen has developed some remarkable characteristics. (forbes.com)