X-linked recessive NEPHROLITHIASIS characterized by HYPERCALCIURIA; HYPOPHOSPHATEMIA; NEPHROCALCINOSIS; and PROTEINURIA. It is associated with mutations in the voltage-gated chloride channel, CLC-5 (Dent Disease I). Another group of mutations associated with this disease is in phosphatidylinositol 4,5-bisphosphate-5-phosphatase gene.
A sex-linked recessive disorder affecting multiple systems including the EYE, the NERVOUS SYSTEM, and the KIDNEY. Clinical features include congenital CATARACT; MENTAL RETARDATION; and renal tubular dysfunction (FANCONI SYNDROME; RENAL TUBULAR ACIDOSIS; X-LINKED HYPOPHOSPHATEMIA or vitamin-D-resistant rickets) and SCOLIOSIS. This condition is due to a deficiency of phosphatidylinositol 4,5-bisphosphate-5-phosphatase leading to defects in PHOSPHATIDYLINOSITOL metabolism and INOSITOL signaling pathway. (from Menkes, Textbook of Child Neurology, 5th ed, p60; Am J Hum Genet 1997 Jun;60(6):1384-8)
Genetic defects in the selective or non-selective transport functions of the KIDNEY TUBULES.
A hereditary or acquired form of generalized dysfunction of the PROXIMAL KIDNEY TUBULE without primary involvement of the KIDNEY GLOMERULUS. It is usually characterized by the tubular wasting of nutrients and salts (GLUCOSE; AMINO ACIDS; PHOSPHATES; and BICARBONATES) resulting in HYPOKALEMIA; ACIDOSIS; HYPERCALCIURIA; and PROTEINURIA.
Cell membrane glycoproteins that form channels to selectively pass chloride ions. Nonselective blockers include FENAMATES; ETHACRYNIC ACID; and TAMOXIFEN.
A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.
Formation of stones in the KIDNEY.
Excretion of abnormally high level of CALCIUM in the URINE, greater than 4 mg/kg/day.
An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.
Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.
A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate. EC 3.1.3.
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Pathological processes of the KIDNEY or its component tissues.
Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
A hereditary disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. Autosomal and X-linked dominant and recessive variants have been reported.

Dent's disease. (1/9)

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ATP induces conformational changes in the carboxyl-terminal region of ClC-5. (2/9)

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Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy. (3/9)

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Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3). (4/9)

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Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease. (5/9)

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Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL. (6/9)

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An atypical Dent's disease phenotype caused by co-inheritance of mutations at CLCN5 and OCRL genes. (7/9)

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Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5. (8/9)

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Dent disease is a rare X-linked recessive genetic disorder that primarily affects the function of the proximal tubules in the kidneys. It is characterized by low molecular weight proteinuria, hypercalciuria, nephrolithiasis (kidney stones), and progressive kidney dysfunction leading to chronic kidney disease or end-stage renal failure in some cases. The disorder is caused by mutations in the CLCN5 gene, which provides instructions for making a chloride channel important for maintaining the proper function of proximal tubular cells in the kidneys. Dent disease primarily affects males, while females are typically asymptomatic carriers of the disorder.

Oculocerebrorenal syndrome, also known as Lowe syndrome, is a rare genetic disorder that primarily affects the eyes, brain, and kidneys. It's characterized by congenital cataracts, intellectual disability, and progressive kidney disease. The condition is caused by mutations in the OCRL gene, which provides instructions for making an enzyme called phosphatidylinositol 4,5-bisphosphate 5-phosphatase. This enzyme plays a crucial role in cell signaling and trafficking within cells.

The symptoms of oculocerebrorenal syndrome can vary widely among affected individuals, but they typically include:

* Eye abnormalities: Most people with the condition are born with congenital cataracts that need to be removed soon after birth. Other eye problems may include glaucoma, strabismus (crossed eyes), and optic nerve damage, which can lead to vision loss.
* Brain abnormalities: Intellectual disability is a common feature of the condition, ranging from mild to severe. Affected individuals may also have delayed development, behavioral problems, and difficulty with coordination and movement.
* Kidney abnormalities: Progressive kidney disease is a hallmark of oculocerebrorenal syndrome. The kidneys may become enlarged and scarred, leading to kidney failure in some cases. Other kidney-related symptoms can include proteinuria (protein in the urine), hematuria (blood in the urine), and high blood pressure.

There is no cure for oculocerebrorenal syndrome, but treatments can help manage the symptoms. For example, cataract surgery can improve vision, while medications and dietary changes can help manage kidney disease. Early intervention and supportive care can also help improve outcomes for affected individuals.

Inborn errors of renal tubular transport refer to genetic disorders that affect the normal functioning of the kidney tubules. The kidney tubules are responsible for the reabsorption and secretion of various substances, including electrolytes and nutrients, as urine is formed. Inherited defects in the proteins that mediate these transport processes can lead to abnormal levels of these substances in the body and may result in a variety of clinical symptoms.

These disorders can affect different parts of the renal tubule, including the proximal tubule, loop of Henle, distal tubule, and collecting duct. Depending on the specific transporter affected, inborn errors of renal tubular transport can present with a range of clinical manifestations, such as electrolyte imbalances, acid-base disorders, growth retardation, kidney stones, nephrocalcinosis, or even kidney failure.

Examples of inborn errors of renal tubular transport include:

1. Distal renal tubular acidosis (dRTA): A genetic disorder that affects the ability of the distal tubule to acidify urine, leading to metabolic acidosis, hypokalemia, and nephrocalcinosis.
2. Bartter syndrome: A group of autosomal recessive disorders characterized by impaired sodium reabsorption in the loop of Henle, resulting in hypokalemia, metabolic alkalosis, and hyperreninemic hyperaldosteronism.
3. Gitelman syndrome: An autosomal recessive disorder caused by a defect in the thiazide-sensitive sodium chloride cotransporter in the distal tubule, leading to hypokalemia, metabolic alkalosis, and hypocalciuria.
4. Liddle syndrome: An autosomal dominant disorder characterized by increased sodium reabsorption in the collecting duct due to a gain-of-function mutation in the epithelial sodium channel (ENaC), resulting in hypertension, hypokalemia, and metabolic alkalosis.
5. Dent disease: An X-linked recessive disorder caused by mutations in the CLCN5 gene, which encodes a chloride channel in the proximal tubule, leading to low molecular weight proteinuria, hypercalciuria, and nephrolithiasis.
6. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC): An autosomal recessive disorder caused by mutations in the CLCN5 or CLDN16 genes, which encode chloride channels in the thick ascending limb of Henle's loop, resulting in hypomagnesemia, hypercalciuria, and nephrocalcinosis.

Fanconi syndrome is a medical condition that affects the proximal tubules of the kidneys. These tubules are responsible for reabsorbing various substances, such as glucose, amino acids, and electrolytes, back into the bloodstream after they have been filtered through the kidneys.

In Fanconi syndrome, there is a defect in the reabsorption process, causing these substances to be lost in the urine instead. This can lead to a variety of symptoms, including:

* Polyuria (excessive urination)
* Polydipsia (excessive thirst)
* Dehydration
* Metabolic acidosis (an imbalance of acid and base in the body)
* Hypokalemia (low potassium levels)
* Hypophosphatemia (low phosphate levels)
* Vitamin D deficiency
* Rickets (softening and weakening of bones in children) or osteomalacia (softening of bones in adults)

Fanconi syndrome can be caused by a variety of underlying conditions, including genetic disorders, kidney diseases, drug toxicity, and heavy metal poisoning. Treatment typically involves addressing the underlying cause, as well as managing symptoms such as electrolyte imbalances and acid-base disturbances.

Chloride channels are membrane proteins that form hydrophilic pores or gaps, allowing the selective passage of chloride ions (Cl-) across the lipid bilayer of cell membranes. They play crucial roles in various physiological processes, including regulation of neuronal excitability, maintenance of resting membrane potential, fluid and electrolyte transport, and pH and volume regulation of cells.

Chloride channels can be categorized into several groups based on their structure, function, and mechanism of activation. Some of the major classes include:

1. Voltage-gated chloride channels (ClC): These channels are activated by changes in membrane potential and have a variety of functions, such as regulating neuronal excitability and transepithelial transport.
2. Ligand-gated chloride channels: These channels are activated by the binding of specific ligands or messenger molecules, like GABA (gamma-aminobutyric acid) or glycine, and are involved in neurotransmission and neuromodulation.
3. Cystic fibrosis transmembrane conductance regulator (CFTR): This is a chloride channel primarily located in the apical membrane of epithelial cells, responsible for secreting chloride ions and water to maintain proper hydration and mucociliary clearance in various organs, including the lungs and pancreas.
4. Calcium-activated chloride channels (CaCCs): These channels are activated by increased intracellular calcium concentrations and participate in various physiological processes, such as smooth muscle contraction, neurotransmitter release, and cell volume regulation.
5. Swelling-activated chloride channels (ClSwells): Also known as volume-regulated anion channels (VRACs), these channels are activated by cell swelling or osmotic stress and help regulate cell volume and ionic homeostasis.

Dysfunction of chloride channels has been implicated in various human diseases, such as cystic fibrosis, myotonia congenita, epilepsy, and certain forms of cancer.

Nephrocalcinosis is a medical condition characterized by the deposition of calcium salts in the renal parenchyma, specifically within the tubular epithelial cells and interstitium of the kidneys. This process can lead to chronic inflammation, tissue damage, and ultimately impaired renal function if left untreated.

The condition is often associated with metabolic disorders such as hyperparathyroidism, distal renal tubular acidosis, or hyperoxaluria; medications like loop diuretics, corticosteroids, or calcineurin inhibitors; and chronic kidney diseases. The diagnosis of nephrocalcinosis is typically made through imaging studies such as ultrasound, CT scan, or X-ray. Treatment usually involves addressing the underlying cause, modifying dietary habits, and administering medications to control calcium levels in the body.

Nephrolithiasis is a medical term that refers to the presence of stones or calculi in the kidney. These stones can form anywhere in the urinary tract, including the kidneys, ureters, bladder, and urethra. Nephrolithiasis is also commonly known as kidney stones.

Kidney stones are hard deposits made up of minerals and salts that crystallize in the urine. They can vary in size from tiny sand-like particles to larger pebble or even golf ball-sized masses. Kidney stones can cause pain, bleeding, and infection if they block the flow of urine through the urinary tract.

The formation of kidney stones is often associated with a variety of factors such as dehydration, high levels of calcium, oxalate, or uric acid in the urine, family history, obesity, and certain medical conditions like gout or inflammatory bowel disease. Treatment for nephrolithiasis depends on the size and location of the stone, as well as the severity of symptoms. Small stones may pass spontaneously with increased fluid intake, while larger stones may require medication, shock wave lithotripsy, or surgical removal.

Hypercalciuria is a medical condition characterized by an excessive amount of calcium in the urine. It can occur when the body absorbs too much calcium from food, or when the bones release more calcium than usual. In some cases, it may be caused by certain medications, kidney disorders, or genetic factors.

Hypercalciuria can increase the risk of developing kidney stones and other kidney problems. It is often diagnosed through a 24-hour urine collection test that measures the amount of calcium in the urine. Treatment may include changes in diet, increased fluid intake, and medications to help reduce the amount of calcium in the urine.

Renal glycosuria is a medical condition characterized by the presence of glucose in the urine due to defective renal tubular reabsorption, despite normal blood glucose levels. In healthy individuals, the kidneys are able to reabsorb all filtered glucose back into the bloodstream. However, in renal glycosuria, the kidneys fail to reabsorb some or all of the glucose, leading to its excretion in the urine.

Renal glycosuria can be congenital or acquired. Congenital renal glycosuria is a rare inherited disorder caused by mutations in the SLC5A2 gene, which encodes the glucose transporter 2 (GLUT2) protein responsible for glucose reabsorption in the kidneys. Acquired renal glycosuria can occur as a result of damage to the renal tubules due to various causes such as diabetes, hypertension, or certain medications.

Renal glycosuria is usually asymptomatic and discovered incidentally during routine urinalysis. However, in some cases, it may lead to increased urinary frequency, urgency, and polyuria due to the osmotic diuretic effect of glucose in the urine. If left untreated, renal glycosuria can increase the risk of urinary tract infections and kidney stones. Treatment is typically not necessary for asymptomatic individuals with renal glycosuria, but monitoring blood glucose levels is recommended to rule out underlying diabetes mellitus.

Kidney calculi, also known as kidney stones, are hard deposits made of minerals and salts that form inside your kidneys. They can range in size from a grain of sand to a golf ball. When they're small enough, they can be passed through your urine without causing too much discomfort. However, larger stones may block the flow of urine, causing severe pain and potentially leading to serious complications such as urinary tract infections or kidney damage if left untreated.

The formation of kidney calculi is often associated with factors like dehydration, high levels of certain minerals in your urine, family history, obesity, and certain medical conditions such as gout or inflammatory bowel disease. Symptoms of kidney stones typically include severe pain in the back, side, lower abdomen, or groin; nausea and vomiting; fever and chills if an infection is present; and blood in the urine. Treatment options depend on the size and location of the stone but may include medications to help pass the stone, shock wave lithotripsy to break up the stone, or surgical removal of the stone in severe cases.

Phosphoric monoester hydrolases are a class of enzymes that catalyze the hydrolysis of phosphoric monoesters into alcohol and phosphate. This class of enzymes includes several specific enzymes, such as phosphatases and nucleotidases, which play important roles in various biological processes, including metabolism, signal transduction, and regulation of cellular processes.

Phosphoric monoester hydrolases are classified under the EC number 3.1.3 by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB). The enzymes in this class share a common mechanism of action, which involves the nucleophilic attack on the phosphorus atom of the substrate by a serine or cysteine residue in the active site of the enzyme. This results in the formation of a covalent intermediate, which is then hydrolyzed to release the products.

Phosphoric monoester hydrolases are important therapeutic targets for the development of drugs that can modulate their activity. For example, inhibitors of phosphoric monoester hydrolases have been developed as potential treatments for various diseases, including cancer, neurodegenerative disorders, and infectious diseases.

The proximal kidney tubule is the initial portion of the renal tubule in the nephron of the kidney. It is located in the renal cortex and is called "proximal" because it is closer to the glomerulus, compared to the distal tubule. The proximal tubule plays a crucial role in the reabsorption of water, electrolytes, and nutrients from the filtrate that has been formed by the glomerulus. It also helps in the secretion of waste products and other substances into the urine.

The proximal tubule is divided into two segments: the pars convoluta and the pars recta. The pars convoluta is the curved portion that receives filtrate from the Bowman's capsule, while the pars recta is the straight portion that extends deeper into the renal cortex.

The proximal tubule is lined with a simple cuboidal epithelium, and its cells are characterized by numerous mitochondria, which provide energy for active transport processes. The apical surface of the proximal tubular cells has numerous microvilli, forming a brush border that increases the surface area for reabsorption.

In summary, the proximal kidney tubule is a critical site for the reabsorption of water, electrolytes, and nutrients from the glomerular filtrate, contributing to the maintenance of fluid and electrolyte balance in the body.

Proteinuria is a medical term that refers to the presence of excess proteins, particularly albumin, in the urine. Under normal circumstances, only small amounts of proteins should be found in the urine because the majority of proteins are too large to pass through the glomeruli, which are the filtering units of the kidneys.

However, when the glomeruli become damaged or diseased, they may allow larger molecules such as proteins to leak into the urine. Persistent proteinuria is often a sign of kidney disease and can indicate damage to the glomeruli. It is usually detected through a routine urinalysis and may be confirmed with further testing.

The severity of proteinuria can vary, and it can be a symptom of various underlying conditions such as diabetes, hypertension, glomerulonephritis, and other kidney diseases. Treatment for proteinuria depends on the underlying cause and may include medications to control blood pressure, manage diabetes, or reduce protein loss in the urine.

Kidney tubules are the structural and functional units of the kidney responsible for reabsorption, secretion, and excretion of various substances. They are part of the nephron, which is the basic unit of the kidney's filtration and reabsorption process.

There are three main types of kidney tubules:

1. Proximal tubule: This is the initial segment of the kidney tubule that receives the filtrate from the glomerulus. It is responsible for reabsorbing approximately 65% of the filtrate, including water, glucose, amino acids, and electrolytes.
2. Loop of Henle: This U-shaped segment of the tubule consists of a thin descending limb, a thin ascending limb, and a thick ascending limb. The loop of Henle helps to concentrate urine by creating an osmotic gradient that allows water to be reabsorbed in the collecting ducts.
3. Distal tubule: This is the final segment of the kidney tubule before it empties into the collecting duct. It is responsible for fine-tuning the concentration of electrolytes and pH balance in the urine by selectively reabsorbing or secreting substances such as sodium, potassium, chloride, and hydrogen ions.

Overall, kidney tubules play a critical role in maintaining fluid and electrolyte balance, regulating acid-base balance, and removing waste products from the body.

Kidney disease, also known as nephropathy or renal disease, refers to any functional or structural damage to the kidneys that impairs their ability to filter blood, regulate electrolytes, produce hormones, and maintain fluid balance. This damage can result from a wide range of causes, including diabetes, hypertension, glomerulonephritis, polycystic kidney disease, lupus, infections, drugs, toxins, and congenital or inherited disorders.

Depending on the severity and progression of the kidney damage, kidney diseases can be classified into two main categories: acute kidney injury (AKI) and chronic kidney disease (CKD). AKI is a sudden and often reversible loss of kidney function that occurs over hours to days, while CKD is a progressive and irreversible decline in kidney function that develops over months or years.

Symptoms of kidney diseases may include edema, proteinuria, hematuria, hypertension, electrolyte imbalances, metabolic acidosis, anemia, and decreased urine output. Treatment options depend on the underlying cause and severity of the disease and may include medications, dietary modifications, dialysis, or kidney transplantation.

Endocytosis is the process by which cells absorb substances from their external environment by engulfing them in membrane-bound structures, resulting in the formation of intracellular vesicles. This mechanism allows cells to take up large molecules, such as proteins and lipids, as well as small particles, like bacteria and viruses. There are two main types of endocytosis: phagocytosis (cell eating) and pinocytosis (cell drinking). Phagocytosis involves the engulfment of solid particles, while pinocytosis deals with the uptake of fluids and dissolved substances. Other specialized forms of endocytosis include receptor-mediated endocytosis and caveolae-mediated endocytosis, which allow for the specific internalization of molecules through the interaction with cell surface receptors.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

I must clarify that the term "pedigree" is not typically used in medical definitions. Instead, it is often employed in genetics and breeding, where it refers to the recorded ancestry of an individual or a family, tracing the inheritance of specific traits or diseases. In human genetics, a pedigree can help illustrate the pattern of genetic inheritance in families over multiple generations. However, it is not a medical term with a specific clinical definition.

Genetic linkage is the phenomenon where two or more genetic loci (locations on a chromosome) tend to be inherited together because they are close to each other on the same chromosome. This occurs during the process of sexual reproduction, where homologous chromosomes pair up and exchange genetic material through a process called crossing over.

The closer two loci are to each other on a chromosome, the lower the probability that they will be separated by a crossover event. As a result, they are more likely to be inherited together and are said to be linked. The degree of linkage between two loci can be measured by their recombination frequency, which is the percentage of meiotic events in which a crossover occurs between them.

Linkage analysis is an important tool in genetic research, as it allows researchers to identify and map genes that are associated with specific traits or diseases. By analyzing patterns of linkage between markers (identifiable DNA sequences) and phenotypes (observable traits), researchers can infer the location of genes that contribute to those traits or diseases on chromosomes.

Familial Hypophosphatemic Rickets (FHR) is a genetic disorder characterized by impaired reabsorption of phosphate in the kidneys, leading to low levels of phosphate in the blood (hypophosphatemia). This condition results in defective mineralization of bones and teeth, causing rickets in children and osteomalacia in adults.

FHR is typically caused by mutations in the PHEX gene, which encodes a protein that helps regulate phosphate levels in the body. In FHR, the mutation leads to an overproduction of a hormone called fibroblast growth factor 23 (FGF23), which increases phosphate excretion in the urine and decreases the activation of vitamin D, further contributing to hypophosphatemia.

Symptoms of FHR may include bowing of the legs, bone pain, muscle weakness, short stature, dental abnormalities, and skeletal deformities. Treatment typically involves oral phosphate supplements and active forms of vitamin D to correct the hypophosphatemia and improve bone mineralization. Regular monitoring of blood phosphate levels, kidney function, and bone health is essential for effective management of this condition.

... (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of ... Wrong had studied with Dent and chose to name the disease after his mentor. Dent's disease is a genetic disorder caused by ... Dent's disease was first described by Charles Enrique Dent and M. Friedman in 1964, when they reported two unrelated British ... and one of 10 women had end-stage kidney disease by the age of 47. Dent's disease is a X-linked recessive disorder. The males ...
Dent died of heart disease on May 23, 1906. Dent was a member of the Assembly in 1876. He was a Republican. The Legislative ... James S. Dent from Menomonee, Wisconsin, was a member of the Wisconsin State Assembly. Dent was born on August 1, 1831, in ... p. 480.{{cite book}}: CS1 maint: location missing publisher (link) James S. Dent at Find a Grave (CS1 maint: location missing ...
On March 29, 2009 Ivor Dent died from Alzheimer's disease. "Dent, Ivor G." Edmonton Public Library. Archived from the original ... Ivor Dent graduated with a Bachelor of Arts in science in 1949. Three years later, he and his wife moved to Edmonton and Dent ... A damaging transit strike cost Dent support from all sides. In the 1974 election, Dent faced credible challenges from former ... Retrieved April 7, 2009.[dead link] Edmonton Public Library Biography of Ivor Dent City of Edmonton biography of Ivor Dent ...
... had Parkinson's disease and died on March 24, 2007. Crisp was active as a volunteer in politics. Her political ... Mary Dent, 1923- - Social Networks and Archival Context". snaccooperative.org. Retrieved 2019-12-04. "Mary Dent Crisp to ... Mary Dent Crisp (November 5, 1923 - March 24, 2007) was an American Republican leader and feminist who was ousted from her ... "MARY DENT CRISP TO ADDRESS PLANNED PARENTHOOD DINNER". themorningcall.com. Retrieved 2019-12-04. Berebitsky, Julie. "Crisp, ...
Dent died of Bright's disease in Grafton in 1909, survived by his widow. Marmaduke Dent was buried at Bluemont Cemetery in ... Although their daughter Virginia Dent had died in 1904, their son Herbert Warder Dent (1880-) followed his father's career path ... Dent also became the first president of its alumni association (from 1873 to 1876). Dent worked as a teacher after graduation, ... Dent papers An American Judge: Marmaduke Dent of West Virginia, John Phillip Reid, New York University Press, 1968. (Articles ...
Dent disease is mainly caused by loss-of-function mutations in the CLCN5 gene (Dent disease 1; MIM#300009). Dent disease 1 ... Mutations in the CLCN5 gene cause an X-linked recessive nephropathy named Dent disease (Dent disease 1 MIM#300009) ... Devuyst O, Thakker RV (October 2010). "Dent's disease". Orphanet Journal of Rare Diseases. 5 (1): 28. doi:10.1186/1750-1172-5- ... is the disease identical to Dent's disease in United Kingdom?". Nephron. 69 (3): 242-7. doi:10.1159/000188464. PMID 7753256. ...
Inactivation of the CLCN5 gene causes Dent's disease Type 1. The rare nature of Dent's disease makes it difficult to coordinate ... "Dent Disease". NORD (National Organization for Rare Disorders). Retrieved 2019-07-22. Aung K, Htay T. Thiazide diuretics and ... Velasco, Nestor; Jayawardene, Satishkumar A.; Burgess, Helen K. (2001-07-01). "Dent's disease: can we slow its progression?". ... Thiazides may be used to treat the symptoms of Dent's disease, an X-linked genetic condition that results in electrolyte ...
Dent's Disease' in honour of his late mentor. This disease is variously termed Dent's disease or Dent disease. Wrong's insights ... Dent-Wrong' disease. Wrong's identification of Dent and Friedman's second patient as having 'clinical' Dent Disease was ... Dent Disease Type 1' due to CLCN5 mutation and the other, 'Dent Disease Type 2' due to OCRL1 mutation. Wrong, who had been ... 2005). "Dent Disease with mutations in OCRL1". Am J Hum Genet. 76 (2): 260-267. doi:10.1086/427887. PMC 1196371. PMID 15627218 ...
The most studied disease is Dent's disease, which is attributed to a mutation in CLCN5 or OCRL1 genes. However, IH patients ... Devuyst, Olivier; Thakker, Rajesh V (2010). "Dent's disease". Orphanet Journal of Rare Diseases. 5 (1): 28. doi:10.1186/1750- ... Sella, Stefania; Cattelan, Catia; Realdi, Giuseppe; Giannini, Sandro (2008). "Bone disease in primary hypercalciuria". Clinical ... blood tests in urine are performed to rule out diseases, such as hematuria that may be underlying the cause of hypercalciuria. ...
Dent addressed tuberculosis and syphilis, diseases that were endemic in New Orleans at the time. He established a weekly ... Their first born child was poet and writer Thomas Dent. Their other children were Benjamin Albert Dent and Walter Jesse Dent. ... For social workers and public health nurses as well as the general public, Dent developed a lecture series on venereal diseases ... Dent's wife Ernestine Jessie Covington Dent (née Ernestine Jessie Covington) was notable in her own right. She was born in 1904 ...
Levtchenko EN, Monnens LA, Bökenkamp A, Knoers NV (2007). "[From gene to disease; Dent's disease caused by abnormalities in the ... February 2005). "Dent Disease with mutations in OCRL1". Am. J. Hum. Genet. 76 (2): 260-7. doi:10.1086/427887. PMC 1196371. PMID ... 2005). "Dent Disease with mutations in OCRL1". Am. J. Hum. Genet. 76 (2): 260-7. doi:10.1086/427887. PMC 1196371. PMID 15627218 ... Deficiencies in OCRL-1 may cause with oculocerebrorenal syndrome and also have been linked to Dent's disease. GRCh38: Ensembl ...
Dent's Disease (Dent 1) is associated with a drop in LRP2/megalin protein level in the proximal tubule with no detectable ... Shipman KE, Weisz OA (2020-09-14). "Making a Dent in Dent Disease". Function. 1 (2): zqaa017. doi:10.1093/function/zqaa017. PMC ... April 2023). "Impaired Endosome Maturation Mediates Tubular Proteinuria in Dent Disease Cell Culture and Mouse Models". Journal ... the gene mutated in Dent's Disease, shortens the half-life of the LRP2 receptor. The loss of ClC-5 has been found to delay the ...
... research into a hereditary disease of the kidneys which was greatly expanded by his pupil Oliver Wrong and named Dent's disease ... He had married Margaret Ruth Coad in 1944; they had six children, among them Emma Dent Coad MP. Dent was a believing Catholic ... He also defined new amino-acid diseases such as various forms of Fanconi syndrome, Hartnup disease, argininosuccinic aciduria ... Dent was appointed a Commander of the Order of the British Empire in the 1976 New Year Honours. He died of leukaemia in 1976. ...
"Dent disease in children: diagnostic and therapeutic considerations". Clinical Nephrology. 84 (4): 222-230. doi:10.5414/ ... It is aiding in the discovery of genes and mutations in patients whose disease are stratified or when the disease in a patient ... Numerous diseases have been caused by cryptic splice site mutations or usage of cryptic splice sites due to the mutations in ... This algorithm has been used to discover disease-causing splice site mutations and cryptic splice sites. A splice site is the ...
Positional cloning of the gene responsible for Dent's disease. ox.ac.uk (DPhil thesis). University of Oxford. OCLC 557355457. ... degree from the University of Oxford in 1995 for research on positional cloning of the gene responsible for Dent's disease ...
Two forms, Dent's disease and Lowe syndrome, are X linked. A recently described form of this disease is due to a mutation in ... a separate disease.[citation needed] Familial renal disease in animals for Fanconi syndrome in Basenjis "Fanconi syndrome" at ... Different diseases underlie Fanconi syndrome; they can be inherited, congenital, or acquired. Cystinosis is the most common ... The loss of phosphate results in the bone diseases rickets and osteomalacia (even with adequate vitamin D and calcium levels), ...
Wu, Fiona (2014). Dent's disease and the chloride channel, CLC-5 (DPhil thesis). University of Oxford. UK Government research ... Thakker, R. V; Whyte, Michael P; Eisman, John; Igarashi, Takashi (2013). Genetics of Bone Biology and Skeletal Disease. ISBN ... and Genetics of Bone Biology and Skeletal Disease. Thakker was elected a Fellow of the Royal Society (FRS) in 2014. His ... Thakker has edited several books including Genetic and Molecular Biological Aspects of Endocrine Disease, Molecular Genetics of ...
Etiology and pathogenesis of periodontal diseases. Dent Clin North Am. 2005; 49:491-516,. Brook I, Frazier EH. Microbiology of ... Reviews of Infectious Disease. 13: 819-822; 1991. Finegold SM. Anaerobic bacteria in human disease. Orlando: Academic Press Inc ... "Pelvic Inflammatory Disease - CDC Fact Sheet". www.cdc.gov. November 19, 2020. Barrett S, Taylor C..A review on pelvic ... Pelvic inflammatory disease. Obstet Gynecol. 2010; 116(2 Pt 1):419-28. Donders G. Diagnosis and management of bacterial ...
Ivor Dent, 85, Canadian Mayor of Edmonton (1968-1974), Alzheimer's disease. Helvecia Viera, 80, Chilean comedian and actress, ... "Former Edmonton mayor Ivor Dent dies". CBC News. March 31, 2009. Archived from the original on February 25, 2018. "Pesar por ... William B. Schwartz dies at 86; renowned kidney disease specialist and researcher". Los Angeles Times. Friedman, Roger (March ... Larry Regan, 78, Canadian ice hockey player and general manager (Los Angeles Kings), Parkinson's disease. Russell Spears, 92, ...
Diseases from space. J.M. Dent. 1980. OCLC 6087814. Hoyle, Fred (2006). Ice: The Ultimate Human Catastrophe. Continuum. ISBN ... ISBN 0460043358 Diseases from Space (with Chandra Wickramasinghe) (J.M. Dent, London, 1979) Commonsense in Nuclear Energy, Fred ... Hoyle, Fred; Wickramasinghe, Chandra (1979). Diseases From Space. London: J.M. Dent. ISBN 978-0460043571. Hoyle, Fred; ... Lifecloud - The Origin of Life in the Universe, Hoyle, F. and Wickramasinghe C., J.M. Dent and Sons, 1978. ...
Thakker RV (March 2000). "Pathogenesis of Dent's disease and related syndromes of X-linked nephrolithiasis" (PDF). Kidney ... Nephrocalcinosis Kidney disease Kidney stone formation in space Schulsinger DA (2014). Kidney Stone Disease: Say NO to Stones ... Metabolic syndrome and its associated diseases of obesity and diabetes as general risk factors for kidney stone disease are ... National Digestive Diseases Information Clearinghouse (2006). "Crohn's Disease (NIH Publication No. 06-3410)". Digestive ...
Calcium metabolism Dent's disease Electrolyte disturbance Disorders of calcium metabolism Minisola, S; Pepe, J; Piemonte, S; ... sarcoidosis and other granulomatous diseases such as tuberculosis, berylliosis, histoplasmosis, Crohn's disease, and ... Hypercalcemia in house pets is typically due to disease, but other cases can be due to accidental ingestion of plants or ... In dogs, lymphosarcoma, Addison's disease, primary hyperparathyroidism, and chronic kidney failure are the main causes of ...
J Am Dent Assoc 2009;140:1259-65. Sedghizadeh PP, Shuler CF, Allen CM, Beck FM, Kalmar JR. Celiac disease and recurrent ... Periodontitis: an archetypical biofilm disease. J Am Dent Assoc 2009;140:978-86. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T ... J Am Dent Assoc 2009;140:61-66. Kumar SKS, Ram S, Jorgensen MG, Shuler CF, Sedghizadeh PP. Multicentric peripheral ossifying ... He characterized the pathology and defined the biofilm microbiology of MRONJ specimens to elucidate mechanisms of disease, ...
ISBN 0-906449-50-2. Hoyle F, Wickramasinghe NC (1979). Diseases from space. London: J.M. Dent. Hoyle F, Wickramasinghe NC (1981 ... These harmful traits range from increased risk of disease, such as cardiovascular disease, to premature death. However, this ... London: J.M. Dent. Liu Y (September 2007). "Like father like son. A fresh review of the inheritance of acquired characteristics ... Liu Y, Li X (May 2016). "Darwin's Pangenesis as a molecular theory of inherited diseases". Gene. 582 (1): 19-22. doi:10.1016/j. ...
Adv Dent Res. 19 (1): 57-62. doi:10.1177/154407370601900112. PMID 16672551. S2CID 9526698. Ravikiran Ongole; Praveen BN (10 Feb ... Motor neuron disease (Lou Gehrig's disease) can cause impaired control of tongue movement, affecting speech and swallowing. ... Tongue diseases can be congenital or acquired, and are multiple in number. Considered according to a surgical sieve, some ... 2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6. Yaqoob, N; Ahmed, Z; ...
Production of eoxins by Reed-Sternburg cells has also led to suggestion that they are involve in Hodgkins disease. However, the ... Dent. Res. 82 (2): 82-90. doi:10.1177/154405910308200202. PMID 12562878. S2CID 40812937. Serhan CN, Gotlinger K, Hong S, Arita ... Between 1929 and 1932, Burr and Burr showed that restricting fat from animal's diets led to a deficiency disease, and first ... Westphal, C; Konkel, A; Schunck, WH (2011). "CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?". ...
Van Dyke TE, Serhan CN (2003). "Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases". J. ... Dent. Res. 82 (2): 82-90. doi:10.1177/154405910308200202. PMID 12562878. S2CID 40812937. Serhan CN, Gotlinger K, Hong S, Arita ...
Dent, London, 1978) Diseases from Space (with Fred Hoyle) (J.M. Dent, London, 1979) Origin of Life (with Fred Hoyle) ( ... doi:10.1111/j.1365-2966.2004.07355.x. Hoyle, Fred (1979). Diseases from Space. London: J.M. Dent & Sons. Hoyle, Fred; ... London: J.M. Dent & Sons. Hoyle, Fred (1981). Comets - a vehicle for panspermia. Dordrecht: D. Reidel Publishing Co. p. 227. ... Diseases from space (Book, 1980). [WorldCat.org] . OCLC 6087814. The origin of life (Book, 1980). [WorldCat.org] . OCLC 7677943 ...
J. M. Dent, 1971; p. 262 "Epidemic Diseases Act". Retrieved 29 March 2022. "General Clauses Act". India Code. Retrieved 29 ... Construction of Indian education service Epidemic Diseases Act General Clauses Act Indian Fisheries Act 23 January - Subhas ...
Dent's disease, and Ménière's disease. A low level of evidence, predominantly from observational studies, suggests that ... Doses of hydrochlorothiazide of 50 mg or less over four years reduced mortality and development of cardiovascular diseases ... line therapy for hypertension were found to reduce total mortality and cardiovascular disease events over a four-year study. ...
Dent corn hybrids are more resistant to the disease than sweet corn, hence do not require insecticides.[citation needed] In ... Sweet corn and popcorn cultivars are more susceptible to Stewart's wilt than field (dent) corn, but some dent corn inbreds and ... Stewart's wilt is a bacterial disease of corn caused by the bacterium Pantoea stewartii. The disease is also known as bacterial ... Munkvold, Gary P.; White, Donald G. (2016-01-01). Compendium of Corn Diseases, Fourth Edition. Diseases and Pests Compendium ...
Dents disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of ... Wrong had studied with Dent and chose to name the disease after his mentor. Dents disease is a genetic disorder caused by ... Dents disease was first described by Charles Enrique Dent and M. Friedman in 1964, when they reported two unrelated British ... and one of 10 women had end-stage kidney disease by the age of 47. Dents disease is a X-linked recessive disorder. The males ...
Dent disease is a chronic kidney disorder that occurs almost exclusively in males. Explore symptoms, inheritance, genetics of ... Dent disease 1 is more common than Dent disease 2.. Dent disease is likely underdiagnosed because it may not be identified in ... Dent disease can result from mutations in the CLCN5 or OCRL gene. Mutations in the CLCN5 gene cause Dent disease 1, which ... Both forms of Dent disease (type 1 and type 2) are characterized by the features described above, but Dent disease 2 can also ...
Dent disease is a chronic kidney disorder that occurs almost exclusively in males. Explore symptoms, inheritance, genetics of ... Dent disease 1 is more common than Dent disease 2.. Dent disease is likely underdiagnosed because it may not be identified in ... Dent disease can result from mutations in the CLCN5 or OCRL gene. Mutations in the CLCN5 gene cause Dent disease 1, which ... Both forms of Dent disease (type 1 and type 2) are characterized by the features described above, but Dent disease 2 can also ...
DPCI Periodontal Disease Dental Wall Chart Poster by Stephen F. Gordon ,,,,, TO ORDER THIS POSTER and have it SHIPPED to you, ... chart, Consultation, Dental, dentist, DISEASE, illustrations, PATIENT, periodontal, poster, Teeth, wall DPCI Periodontal ... Disease Dental Wall Chart Poster by Stephen F. Gordon ,,,,, TO ORDER THIS POSTER and have it SHIPPED to you, click the "Buy in ...
The portal for rare diseases and orphan drugs ... Dent disease type 1. Disease definition A rare X-linked ... The portal for rare diseases and orphan drugs. COVID-19 & Rare diseases. Rare Diseases Resources for Refugees/Displaced Persons ... Dent disease type 1 is caused by inactivating mutations in the CLCN5 gene (Xp11.22) that encodes a 746 amino acid electrogenic ... Of these, approximately half have mutations in the OCRL1 gene and are considered to have Dent disease type 2. ...
... and treatments of periodontal diseases, their impact beyond oral health, and the importance of proactive care. ... 19 July 2023 Swiss Dent Bodrum 0 Periodontal Diseases: Symptoms, Causes and Treatment Periodontal diseases, commonly known as ... Heart Disease: Theres a noted correlation between periodontal disease and heart disease. While the exact reasons are still ... Furthermore, severe gum disease can affect blood sugar control.. *Pregnancy Complications: Gum diseases can increase the risk ...
The disease is caused by mutations in either the CLCN5 (Dent disease 1) or OCRL1 (Dent disease 2) genes that are located on ... and there is considerable intra-familial variability in disease severity. A few patients with Dents disease do not harbour ... The phenotype of Dents disease is explained by the predominant expression of ClC-5 in the proximal tubule segments of the ... The care of patients with Dents disease is supportive, focusing on the treatment of hypercalciuria and the prevention of ...
Dent died of heart disease on May 23, 1906. Dent was a member of the Assembly in 1876. He was a Republican. The Legislative ... James S. Dent from Menomonee, Wisconsin, was a member of the Wisconsin State Assembly. Dent was born on August 1, 1831, in ... p. 480.{{cite book}}: CS1 maint: location missing publisher (link) James S. Dent at Find a Grave (CS1 maint: location missing ...
Entdecke Neurological Diseases 9781684202249 auf Global-dent.com. Fachhändler für Zahnarzt- und Laborbedarf. ✓ Ausführliche ... The text starts with an introduction to neurological diseases followed by eight disease specific chapters: Parkinson Disease, ... How disease-specific oral medications impact patients in dental care settings, prior to and during treatment.. Why ... Neurological Diseases: Implications in Medical and Dental Practices by Armin Ariana provides essential details on managing the ...
Periodontal Disease and Osteoporosis Periodontal disease is characterized by a progressive loss of supportive gingival tissue ... Here are some methods commonly used to diagnose and treat the diseases:. * Routine dental X-rays - X-rays can be effectively ... Osteoporosis and periodontal disease are much less dangerous if they are diagnosed in the early stages. Once a diagnosis has ... Periodontal disease occurs when toxins found in oral plaque inflame and irritate the soft tissues surrounding the teeth. If ...
Periodontitis, usually known as gum disease, impacts round half of all adults. Extreme periodontitis is the sixth most typical ... A wholesome life-style is essential: periodontitis is a power inflammatory disease and situations that elevate irritation ... from https://medicalxpress.com/information/2020-07-international-consensus-guidelines-gum-disease.html ...
Glomerular pathology in dent disease and its association with kidney function. Xiangling Wang, Franca Anglani, Lada Beara-Lasic ... Dive into the research topics of Glomerular pathology in dent disease and its association with kidney function. Together they ...
Study Ties Gum Disease to High Blood Pressure - Consumer Health News. by DNWS ...
To date, Dents disease has been reported in around 250 families (Devuyst and Thakker 2010; Lieske et al. 2012). ... 2012). Dent disease is an X-linked proximal renal tubule dysfunction disorder associated with low-molecular-weight proteinuria ... The disease is advanced to end-stage renal disease (ESRD) in 30 to 80% of affected males around 3rd - 5th decades of life. ... Males in their early childhood (, 10 yrs of age) show the disease phenotype, whereas female carriers may show a milder ...
Kidney stone disease is common and can be associated with alterations in urinary solute composition. Here, the authors outline ... Kidney stone disease (nephrolithiasis) is a common problem that can be associated with alterations in urinary solute ... Effect of hydrochlorothiazide on urinary calcium excretion in Dent disease: an uncontrolled trial. Am. J. Kidney Dis. 52, 1084- ... Dent disease with mutations in OCRL1. Am. J. Hum. Genet. 76, 260-267 (2005). ...
Cardiovascular disease is potentially catastrophic and deadly. And we need to use every tool in our arsenal to deal with it. ... A Cardiologists View: We Must Use Digital Tools to Make a Dent in Heart Disease. Dr. Edo Paz. SVP, Medical Affairs at Hello ... But there is much more work to do, especially when it comes to the number one killer in the U.S.: cardiovascular disease. ... ‍Using Technology to Prevent and Manage Heart Disease At Hello Heart, we dont just use technology to improve the delivery of ...
J Clin Pediatr Dent Assunto da revista: Odontologia / Pediatria Ano de publicação: 2023 Tipo de documento: Artigo País de ... J Clin Pediatr Dent Assunto da revista: Odontologia / Pediatria Ano de publicação: 2023 Tipo de documento: Artigo País de ... Although periodontal diseases have been widely reported in patients with juvenile idiopathic arthritis (JIA), their association ... This systematic review and meta-analysis aimed to evaluate the association between JIA and periodontal diseases to facilitate ...
Dive into the research topics of Digenic mutations of human OCRL paralogs in Dents disease type 2 associated with Chiari i ... Digenic mutations of human OCRL paralogs in Dents disease type 2 associated with Chiari i malformation. ...
Dent Disease with mutations in OCRL1. Am J Hum Genet. 2005 Feb. 76(2):260-7. [QxMD MEDLINE Link]. [Full Text]. ... In Dent disease, loss of low-molecular-weight proteins may exceed 2 g/day; hypercalciuria, nephrolithiasis, and ... Proximal tubular dysfunction is unusual, except for tubular proteinuria and the aminoaciduria of Dent disease ... Nephrocalcinosis can lead to progressive chronic kidney disease and eventually end-stage renal disease requiring dialysis. ...
J Dent Res. 2003;82:123-126.. *National Institute of Dental and Craniofacial Research. Periodontal (Gum) Disease website. https ... Gum (periodontal) disease is an inflammatory disease that affects the hard and soft structures that support the teeth.1 ... Nearly half (46%) of all adults aged 30 years or older show signs of gum disease; severe gum disease affects about 9% of adults ... Gum disease is a leading cause of tooth loss.2 *Tooth loss may affect the ability to chew food and can get worse with the ...
... ulcerative colitis and Crohns disease), medullary sponge kidney, gout, diabetes, and Dents disease ... National Organization for Rare Disorders: "Dent Disease.". Kettering Health Network: "What You Should Know About Kidney Stones ... The Mayo Clinic: "Diseases and Conditions: Kidney Stones," "Inflammatory bowel disease (IBD)," "Triamterene And ... National Institute of Diabetes and Digestive and Kidney Diseases: "Kidney Stones in Adults." ...
... renal diseases (renal osteodystrophy, Fanconi syndrome), tumor-induced osteomalacia, hypophosphatasia, McCune-Albright syndrome ... Several diseases can result in disorders of bone mineralization in children, including rickets, ... CLCN5 is affected in Dent disease type 1 and OCRL1 is affected in Dent disease type 2. Other genes may also be involved, ... Lowe disease and Dent disease are familial forms of Fanconi. Two different genes have been identified as being involved in the ...
Wrong OM, Norden AGW, Feest TG: Dents disease; a familial proximal renal tubualar syndrome with low-molecular-weight ... Due to its rarity, experience at most centers with this disease is limited. Methods: A secure, web-based, institutional review ... Nineteen of the 95 patients were first recognized to have PH after they had reached end-stage renal disease, with the diagnosis ... Efficacy of Rituximab for Minimal Change Disease and Focal Segmental Glomerulosclerosis with Frequently Relapsing or Steroid- ...
Sucrose, Neutrophilic Phagocytosis, and Resistance to Disease. Dent Surv 1976; 52 (12): 46-48 4. DaCosta JC, Beardsley E. The ... DISEASES ∇ *INTRODUCTION *Many serious diseases which were either unknown or rare suddenly took off in the 20th century. All ... disease for much of the waking day. No wonder cancers and infectious diseases are increasing. ... Carbohydrates Harm our Immunity to Disease The high level of sugar in modern diets has been of concern for many years, mainly ...
Dent disease. *ibuprofen overdose. *lamivudine. *antiviral therapy (cidofovir, adefovir, or tenofovir). *programmed cell death ...
Dent disease: classification, heterogeneity and diagnosis. Jin YY, Huang LM, Quan XF, Mao JH. Jin YY, et al. Among authors: mao ...
Marsh, P. Microbial Ecology of Dental Plaque and its Significance in Health and Disease. Adv. Dent. Res. 1994, 8, 263-271. [ ... Dental diseases are among the most common chronic diseases in the world [1,2]. According to the World Health Organization, 60- ... Indian J. Dent. Res. 2016, 27, 609-617. [Google Scholar] [CrossRef]. *Srikanth, K.; Chandra, R.V.; Reddy, A.A.; Reddy, B.H.; ... J. Dent. 2013, 10, 264-272. [Google Scholar]. *Trindade, F.; Oppenheim, F.G.; Helmerhorst, E.J.; Amado, F.; Gomes, P.S.; ...
Scientist Peter Hotez has spent nearly 40 years trying to treat and eliminate the diseases that worms can cause. And he wont ... Now were worried about hookworm [disease] and schistosomiasis. We havent made much of a dent in those diseases. The strategy ... Tell me something surprising about worm diseases. They affect the poor living in the U.S. Theres a disease called toxocariasis ... HIV/AIDS and malaria are killer diseases. Worm [diseases] generally are not. ...
Germany to Test Genomics-Based Precision Medicine for Cancer, Rare Disease in National Pilot Project Premium ... Garvan Institute Gets A$11.6M From Australian Government to Develop Genomics-Based Disease Tests ... and cardiovascular disease and ACE inhibitor use and risk of death, due to concerns regarding the data used in their analyses. ...
  • Periodontal diseases, commonly known as gum diseases, are infections that affect the structures around the teeth, including the gums, periodontal ligament, and alveolar bone. (swissdentbodrum.com)
  • Early detection of periodontal diseases can lead to more effective treatments. (swissdentbodrum.com)
  • Research indicates that older individuals have the highest rates of periodontal diseases. (swissdentbodrum.com)
  • Chronic stress can weaken the immune system, making it harder for the body to fend off infections, including periodontal diseases. (swissdentbodrum.com)
  • There's a noted correlation between periodontal disease and heart disease. (swissdentbodrum.com)
  • While the exact reasons are still under research, inflammation due to periodontal disease might be responsible. (swissdentbodrum.com)
  • People with diabetes are more susceptible to infections, including periodontal diseases. (swissdentbodrum.com)
  • Understanding periodontal diseases, their symptoms, and causes is crucial for early detection and treatment. (swissdentbodrum.com)
  • Periodontal disease is characterized by a progressive loss of supportive gingival tissue in the gums and jawbone. (tramelandbrowndentistry.com)
  • Periodontal disease occurs when toxins found in oral plaque inflame and irritate the soft tissues surrounding the teeth. (tramelandbrowndentistry.com)
  • Many studies have explored and identified a connection between periodontal disease and osteoporosis. (tramelandbrowndentistry.com)
  • A study conducted at the University of New York at Buffalo in 1995 concluded that post-menopausal women who suffered from osteoporosis were 86% more likely to also develop periodontal disease. (tramelandbrowndentistry.com)
  • Low mineral bone density - This is thought to be one of several causes of osteoporosis, and the inflammation from periodontal disease makes weakened bones more prone to break down. (tramelandbrowndentistry.com)
  • Osteoporosis and periodontal disease are much less dangerous if they are diagnosed in the early stages. (tramelandbrowndentistry.com)
  • Routine dental X-rays - X-rays can be effectively used to screen for bone loss in the upper and lower jaw, and the dentist can provide interventions for preventing and treating periodontal disease. (tramelandbrowndentistry.com)
  • It is believed that minimizing periodontal disease will help treat osteoporosis. (tramelandbrowndentistry.com)
  • Estrogen supplements - Providing post-menopausal women with estrogen supplements lowers the rate of attachment loss and also lowers gingival inflammation, which in turn protects the teeth from periodontal disease. (tramelandbrowndentistry.com)
  • If you have any questions about periodontal disease and its connection with osteoporosis, please contact our practice. (tramelandbrowndentistry.com)
  • Association between juvenile idiopathic arthritis and periodontal diseases: a systematic review and meta-analysis. (bvsalud.org)
  • Although periodontal diseases have been widely reported in patients with juvenile idiopathic arthritis (JIA), their association with JIA remains controversial. (bvsalud.org)
  • This systematic review and meta-analysis aimed to evaluate the association between JIA and periodontal diseases to facilitate oral health management and periodontal disease prevention in JIA patients . (bvsalud.org)
  • This systematic review and meta-analysis showed a possible association between JIA and periodontal diseases . (bvsalud.org)
  • Gum (periodontal) disease is an inflammatory disease that affects the hard and soft structures that support the teeth. (cdc.gov)
  • Patient Resources, What Is Periodontal Disease website. (cdc.gov)
  • Periodontal (Gum) Disease website. (cdc.gov)
  • Over the past two decades, there has been an increasing interest in the possible link between dental disease, specifically periodontal disease, and cardiovascular disease. (bmj.com)
  • 2 Consequently, contributing factors associated with inflammation and chronic infections, including oral infections such as periodontal disease, have been investigated to explain the relation between dental disease and cardiovascular disease. (bmj.com)
  • Poor oral hygiene is the major cause of periodontal disease, a chronic infection of the tissue surrounding the teeth. (bmj.com)
  • Previous smaller epidemiological studies that have examined the association between oral health and cardiovascular disease have generally used clinical assessments to identify periodontal disease. (bmj.com)
  • Self reported measures of oral hygiene have been associated with clinically confirmed periodontal disease. (bmj.com)
  • Therefore, given the general acceptability of prognostic systems 11 and the availability of supportive therapy for periodontal diseases, a system was developed for determining the prognosis in cases of PIMI and selecting appropriate supportive implant therapy. (jcda.ca)
  • Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. (wikipedia.org)
  • Dent's disease" is often used to describe an entire group of familial disorders, including X-linked recessive nephrolithiasis with kidney failure, X-linked recessive hypophosphatemic rickets, and both Japanese and idiopathic low-molecular-weight proteinuria. (wikipedia.org)
  • Dent's disease is a X-linked recessive disorder. (wikipedia.org)
  • The mechanisms by which CLC-5 dysfunction results in hypercalciuria and the other features of Dent's disease remain to be elucidated. (wikipedia.org)
  • citation needed] As of today, no agreed-upon treatment of Dent's disease is known and no therapy has been formally accepted. (wikipedia.org)
  • A combination of 25 mg of chlorthalidone plus 5 mg of amiloride daily led to a substantial reduction in urine calcium in Dent's patients, but urine pH was "significantly higher in patients with Dent's disease than in those with idiopathic hypercalciuria (P (wikipedia.org)
  • Dent's disease was first described by Charles Enrique Dent and M. Friedman in 1964, when they reported two unrelated British boys with rickets associated with renal tubular damage characterized by hypercalciuria, hyperphosphaturia, proteinuria, and aminoaciduria. (wikipedia.org)
  • Dent's disease is a genetic disorder caused by mutations in the gene CLCN5, which encodes a kidney-specific voltage-gated chloride channel, a 746-amino-acid protein (CLC-5) with 12 to 13 transmembrane domains. (wikipedia.org)
  • Because of its rather rare occurrence, Dent's disease is often diagnosed as idiopathic hypercalciuria, i.e., excess calcium in urine with undetermined causes. (wikipedia.org)
  • Dent's disease is a renal tubular disorder characterized by manifestations of proximal tubule dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. (ox.ac.uk)
  • The phenotype of Dent's disease is explained by the predominant expression of ClC-5 in the proximal tubule segments of the kidney. (ox.ac.uk)
  • A few patients with Dent's disease do not harbour mutations in CLCN5 and OCRL1, pointing to the involvement of other genes. (ox.ac.uk)
  • The care of patients with Dent's disease is supportive, focusing on the treatment of hypercalciuria and the prevention of nephrolithiasis. (ox.ac.uk)
  • The murine homologues of the loci for McLeod syndrome (XK), Dent's disease (CICN5), and synaptophysin (SYP) have been mapped to the proximal region of the mouse X chromosome and positioned with respect to other conserved loci in this region using a total of 948 progeny from two separate Mus musculus x Mus spretus backcrosses. (mpi.nl)
  • However, some females who carry a mutation in the CLCN5 or OCRL gene have mild features of Dent disease, including proteinuria and hypercalciuria. (medlineplus.gov)
  • A rare X-linked monogenic renal tubular disease, characterized by manifestations of complex proximal tubule dysfunction with low-molecular-weight (LMW) proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. (orpha.net)
  • The diagnosis is based on the presence of LMW proteinuria, which is associated in the majority of cases with hypercalciuria and other biological, radiological and clinical symptoms of the disease. (orpha.net)
  • Dent disease is an X-linked proximal renal tubule dysfunction disorder associated with low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. (preventiongenetics.com)
  • Kidney stone disease (nephrolithiasis) is a common problem that can be associated with alterations in urinary solute composition including hypercalciuria. (nature.com)
  • J Clin Pediatr Dent;47(5): 19-31, 2023 Sep. (bvsalud.org)
  • About 60% of patients have mutations in the CLCN5 gene (Dent 1), which encodes a kidney-specific chloride/proton antiporter, and 15% of patients have mutations in the OCRL1 gene (Dent 2). (wikipedia.org)
  • Dent disease can result from mutations in the CLCN5 or OCRL gene. (medlineplus.gov)
  • Mutations in the CLCN5 gene cause Dent disease 1, which accounts for about 60 percent of all cases of Dent disease. (medlineplus.gov)
  • Studies suggest that mutations in the CLCN5 or OCRL gene disrupt the reabsorption function of the proximal tubules, which leads to the progressive kidney problems found in people with Dent disease. (medlineplus.gov)
  • Dent disease type 1 is caused by inactivating mutations in the CLCN5 gene (Xp11.22) that encodes a 746 amino acid electrogenic Cl-/H+ exchanger (ClC-5). (orpha.net)
  • Approximately 40% of patients with a phenotype compatible with Dent disease do not have CLCN5 mutations. (orpha.net)
  • The disease is caused by mutations in either the CLCN5 (Dent disease 1) or OCRL1 (Dent disease 2) genes that are located on chromosome Xp11.22 and Xq25, respectively. (ox.ac.uk)
  • Candidates for this test are patients with symptoms consistent with Lowe syndrome and Dent disease - 2 (negative for CLCN5 gene pathogenic variants ) , family members of patients who have known mutations and carrier testing for at-risk family members. (preventiongenetics.com)
  • Both Lowe syndrome (oculocerebrorenal syndrome) and Dent disease can be caused by truncating or missense mutations in OCRL. (wikipedia.org)
  • Of these, approximately half have mutations in the OCRL1 gene and are considered to have Dent disease type 2. (orpha.net)
  • For a more thorough review of the role of phosphatidylinositol and the cellular and physiological functions of OCRL1 please refer to the following 2 reviews: (1) McCrea HJ, De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. (medscape.com)
  • However because these mutations do not cause disease directly, it is more likely that they make people more susceptible to the PD when in cooperation with other risk factors ( Lesage and Brice, 2009 ). (frontiersin.org)
  • The most frequent sign of Dent disease is the presence of an abnormally large amount of proteins in the urine (tubular proteinuria). (medlineplus.gov)
  • Some researchers consider Dent disease 2 to be a mild variant of a similar disorder called Lowe syndrome . (medlineplus.gov)
  • [ 1 ] These studies provide strength to the classification of Lowe syndrome as part of the ciliopathy-associated diseases. (medscape.com)
  • How can we possibly make a dent in the problem of overpopulation, abandonment, and disease - not to mention other issues? (catster.com)
  • Dental caries: a dynamic disease process. (thejcdp.com)
  • Enamel remineralization: controlling the caries disease or treating early caries lesions? (thejcdp.com)
  • Ng MW, Sulyanto R: Chronic disease management of caries in children and the role of silver diamine fluoride. (msdmanuals.com)
  • Hong M, Vuong C, Allred EN, Ng MW, Sulyanto R: Sealed primary molars are less likely to develop caries. (msdmanuals.com)
  • Dent disease 2 (nephrolithiasis type 2) is associated with the OCRL gene. (wikipedia.org)
  • Care is supportive, focusing on the prevention of nephrolithiasis, maintaining appropriate hydration and treatment of chronic kidney disease, if present. (orpha.net)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Due to its rarity, experience at most centers with this disease is limited. (karger.com)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The relatively high prevalence rate and the anatomical distribution of the lesions indicate the infectious nature of the disease, which we believe is influenced to a large extent by the lifestyle in these communities. (nih.gov)
  • Peri-implant diseases are characterized by inflammatory lesions that may affect just the peri-implant mucosa (mucositis) or that may also result in loss of the supporting bone (peri-implantitis). (jcda.ca)
  • No genotype-phenotype correlation has been described thus far, and there is considerable intra-familial variability in disease severity. (ox.ac.uk)
  • 10 yrs of age) show the disease phenotype, whereas female carriers may show a milder phenotype. (preventiongenetics.com)
  • At the genomic level, it is rather difficult to analyze the disease, especially sporadic PD, from a single gene mutation, and it is more the imbalance in gene expression and phenotypic changes were caused by a variety of regulatory mechanisms which act as mediators between genotype and phenotype. (frontiersin.org)
  • Dental and medical doctors well report the oral manifestations of coronavirus disease 2019 (COVID-19) infection. (thieme-connect.com)
  • Abbreviation: COVID-19, coronavirus disease 2019. (thieme-connect.com)
  • Genetics of kidney stone disease-Polygenic meets monogenic. (cdc.gov)
  • Subjects Patients aged 30-84 years who were free of cardiovascular disease and not taking statins between 1 January 1994 and 30 April 2010: 2 343 759 in the derivation dataset, and 1 267 159 in the validation dataset. (bmj.com)
  • It should be kept in mind, however, that nephrocalcinosis in rats is a poor model for humans because of the high incidence of spontaneous glomerulosclerosis in laboratory rats, the different distribution of calcium in the kidney, and the absence of a rat model for many of the diseases that cause human nephrocalcinosis. (medscape.com)
  • However, there are many more genes with smaller disease risk that could account for much larger proportion of breast cancer. (cdc.gov)
  • The clinician should be aware that patients with longstanding hypertension and cerebrovascular disease are at increased risk of a cerebrovascular accident. (medscape.com)
  • The Canadian Task Force on Preventive Health Care recommends not screening adults with chronic gastroesophageal reflux disease (GERD) for esophageal adenocarcinoma and precursor conditions (Barrett esophagus or dysplasia), because there is an absence of evidence for benefit, and there are uncertain harms, important resource implications and variable patient values and preferences. (cmaj.ca)
  • Gastroesophageal Reflux Disease (GERD) is an extremely common condition with a number of both medical and surgical treatment options. (sages.org)
  • This set of symptoms was not given a name until 30 years later, when the nephrologist Oliver Wrong more fully described the disease. (wikipedia.org)
  • Researchers have described two forms of Dent disease, which are distinguished by their genetic cause and pattern of signs and symptoms. (medlineplus.gov)
  • Dent disease is likely underdiagnosed because it may not be identified in people with mild signs and symptoms, and because its features overlap with those of other kidney disorders. (medlineplus.gov)
  • Knowing the clinical signs and symptoms of a stroke is important in managing older patients with longstanding cardiovascular disease. (medscape.com)
  • ABSTRACT Sedentary lifestyle is a major underlying cause of death, disease, and disability worldwide. (who.int)
  • Because the OCRL gene is active (expressed) throughout the body, it is unclear why Dent disease 2 primarily affects the kidneys and, to a lesser extent, the brain, eyes, and other tissues. (medlineplus.gov)
  • Surveys were linked prospectively to clinical hospital records, and Cox proportional hazards models were used to estimate the risk of cardiovascular disease events or death according to oral hygiene. (bmj.com)
  • Conclusions Poor oral hygiene is associated with higher levels of risk of cardiovascular disease and low grade inflammation, though the causal nature of the association is yet to be determined. (bmj.com)
  • 1 Inflammation plays an important role in the pathogenesis of atherosclerosis, and markers of low grade inflammation have been consistently associated with a higher risk of cardiovascular disease. (bmj.com)
  • Objective To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease. (bmj.com)
  • 1 National policies now support targeting of interventions to reduce risk of cardiovascular disease among high risk patients. (bmj.com)
  • 4 5 6 7 Systemic inflammation could represent the underlying mechanism that links oral health and cardiovascular disease. (bmj.com)
  • Periodontitis is a highly prevalent, chronic multifactorial infectious disease, induced by the dysbiotic biofilm that triggers a persistent systemic inflammation and recurrent bacteremia. (intechopen.com)
  • There is a growing body of scientific evidence that suggests the potential implication of periodontitis in the causation and progression of various systemic disease and conditions, such as diabetes, cardiovascular disease, pulmonary disease, adverse pregnancy outcomes and cancer. (intechopen.com)
  • In about 74% (411) of cardiovascular disease events the principal diagnosis was coronary heart disease. (bmj.com)
  • Patients identified as high risk with the lifetime risk approach were more likely to be younger, male, from ethnic minority groups, and have a positive family history of premature coronary heart disease than those identified with the 10 year QRISK2 score. (bmj.com)
  • Identification of a monogenic cause of kidney stone disease facilitates optimal stone prevention management and identification of associated phenotypes. (nature.com)
  • Its main purpose is early detection and treatment of asymptomatic disease, or risk assessment and prevention of future disease, in order to improve health outcomes in individuals and populations. (cdc.gov)
  • Diseases such as diabetes, HIV, and cancer can affect gum health. (swissdentbodrum.com)
  • Diabetes, tobacco use, a weakened immune system, and poor oral hygiene all increase a person's risk for gum disease. (cdc.gov)
  • Las personas que consumen más licopeno en su dieta no parecen tener un riesgo menor de desarrollar diabetes. (medlineplus.gov)
  • Recognizing that oral diseases are highly prevalent, with more than 3.5 billion people suffering from them, and that oral diseases are closely linked to noncommunicable diseases, leading to a 1 Document A74/10 Rev.1. (who.int)
  • Mild gum disease can be controlled and treated with good oral hygiene and regular professional cleaning. (cdc.gov)
  • The text starts with an introduction to neurological diseases followed by eight disease specific chapters: Parkinson Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis (ALS), Alzheimer Disease, Stroke, Epilepsy and Other Seizure Disorders, Myasthenia Gravis, and Facial Paralysis. (global-dent.com)
  • Neurologic conditions facing the dentist include abnormalities associated with the cranial nerves, facial sensory loss, facial paralysis, and conditions such as epilepsy, Parkinson disease, multiple sclerosis, stroke, and myasthenia gravis. (medscape.com)
  • Preventing Chronic Disease [serial online] 2004 Jan [ date need to redesign the current surveillance system to cap- cited ]. (cdc.gov)
  • The American Academy of Periodontology has extra on gum disease . (dentnews.eu)
  • Once a diagnosis has been made, the dentist will generally work with the patient's doctor to ensure that both diseases are effectively controlled. (tramelandbrowndentistry.com)
  • 5 The diagnosis of peri-implant disease requires the use of probing techniques to identify the presence or absence of bleeding, pain and suppuration, all of which indicate clinical inflammation. (jcda.ca)
  • A Clinical Workflow for Cost-Saving High-Rate Diagnosis of Genetic Kidney Diseases. (cdc.gov)
  • The diagnosis of a sexually transmitted result found clinical trials on the mechanisms of HPV disease (STD) in a child agrees with the complaint transmission in children and association with sexual of sexual abuse, and motivates a research when abuse.Additional ethical and legal aspects were there is no such claim9.10. (bvsalud.org)
  • They range from simple gum inflammation to severe disease that can result in major damage to soft tissue and bone. (swissdentbodrum.com)
  • Objective To examine if self reported toothbrushing behaviour is associated with cardiovascular disease and markers of inflammation (C reactive protein) and coagulation (fibrinogen). (bmj.com)
  • Disease related to peri-implant mucosal inflammation (PIMI) has been reported as one of the major factors leading to failure of dental implants. (jcda.ca)
  • Unique guide to coordinated and optimized treatment of common neurological diseases. (global-dent.com)
  • This book is essential reading for medical students during neurology rotation, dental students who need clinical insights on how to treat patients with neurological diseases, and early-career medical and dental practitioners. (global-dent.com)
  • Neurological and neurodegenerative diseases have a significant impact on a patient's functionality, independence, and overall quality of life. (global-dent.com)
  • Neurological Diseases: Implications in Medical and Dental Practices by Armin Ariana provides essential details on managing the neurological diseases commonly seen by general healthcare and dental practitioners and the importance of collaborative treatment. (global-dent.com)
  • Patients with neurological disease require special management considerations. (medscape.com)
  • Furthermore, severe gum disease can affect blood sugar control. (swissdentbodrum.com)
  • severe gum disease affects about 9% of adults. (cdc.gov)
  • Although vaccines dramatically reduce the chances of severe disease and death, they have not made a significant dent on transmission. (wkyc.com)
  • Bacteria from the mouth can be inhaled, potentially leading to respiratory diseases like pneumonia. (swissdentbodrum.com)
  • How disease-specific oral medications impact patients in dental care settings, prior to and during treatment. (global-dent.com)
  • 2 Global Burden of Disease 2017 Oral Disorders Collaborators, Bernabe E, Marcenes W et. (who.int)
  • Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: A systematic analysis for the Global Burden of Disease 2017 study. (who.int)
  • El licopeno ha sido utilizado con mayor frecuencia por adultos en dosis de 15 a 45 mg por vía oral al día durante un máximo de 6 meses. (medlineplus.gov)
  • Assessment of risk factors - Dentists and doctors are able to closely monitor the patients that are at an increased risk of developing both diseases by assessing family history, medical history, X-ray results, current medications and modifiable risk factors. (tramelandbrowndentistry.com)
  • Fig. 1: Radiographic appearance of kidney stone disease in three patients. (nature.com)
  • The Lancet and the New England Journal of Medicine retracted papers last week that examined hydroxychloroquine and chloroquine use and risk of death among COVID-19 patients, and cardiovascular disease and ACE inhibitor use and risk of death, due to concerns regarding the data used in their analyses. (genomeweb.com)
  • The knowledge-oriented ques- if patients conceal their disease status was reached. (who.int)
  • Dent died of heart disease on May 23, 1906. (wikipedia.org)
  • But I couldn't help but notice that these critical events were often preceded by years of missed opportunities - chances to treat high blood pressure, high cholesterol, and other known risk factors for heart disease. (helloheart.com)
  • Many in the UK will have heard on the news today that yet another study from Harvard University [1] has linked the eating of red and processed meat with an increased risk of heart disease and cancer. (second-opinions.co.uk)
  • Increased understanding of the genetic factors contributing to kidney stone disease helps to improve our understanding of the pathogenesis of this condition. (nature.com)
  • Advances in our understanding of the polygenic factors contributing to risk of kidney stone disease might enable a precision medicine approach. (nature.com)
  • Update on Hereditary Kidney Stone Disease and Introduction of a New Clinical Patient Registry in Germany. (cdc.gov)
  • Parkinson's disease (PD) is a quite common neurodegenerative disorder with a prevalence of approximately 1:800-1,000 in subjects over 60 years old. (frontiersin.org)
  • Articles about the causes and treatment of peri-implant disease are now being published. (jcda.ca)
  • Dent disease is a chronic kidney disorder that occurs almost exclusively in males. (medlineplus.gov)
  • This month, when Liu-Seifert opens her laptop inside The Cave and pores over the thousands of rows of numbers and decimals, she will discover whether the iconic Indianapolis pharmaceutical company has solved one of the most difficult riddles in medicine: how to slow the cognitive decline caused by Alzheimer's disease. (indianapolismonthly.com)
  • Prevalence of dementia is expected to increase three- to DOH) Alzheimer's Disease and Other Dementias Registry four-fold in the next 50 years. (cdc.gov)
  • We do not established the Alzheimer's Disease and Other Dementias intend to offer a formal evaluation of the Registry, Registry, one of a few such registries in the United States. (cdc.gov)
  • cians, and other stakeholders, a bill establishing the Hospitals and nursing homes document dementia and Alzheimer's Disease and Other Dementias Registry comorbidities more effectively among frail individuals and became law in 1986. (cdc.gov)
  • Alzheimer's disease, but these bills were never enacted. (cdc.gov)
  • These include occurrence, frequency, incidence, cause, effect and prog- indices of frequency and severity of disease, disparities or nosis of Alzheimer's disease' and maintain this informa- inequities, costs, preventability, potential clinical course in tion for research purposes (2). (cdc.gov)
  • Dent disease is inherited in an X-linked recessive pattern . (medlineplus.gov)
  • He said super-infectious relatives of the omicron variant were driving new waves of disease across the continent and that repeat infections could potentially lead to long COVID. (wkyc.com)
  • If you are a healthcare provider, click here to see the Infectious Diseases Society of America's Clinical Practice Guidelines for the Management of CandidiasisExternal external icon . (cdc.gov)
  • Long-term treatment with a high citrate diet or supplementation might delay progression of renal disease, even in the absence of stone formation. (orpha.net)