Congenital displacement of the lens resulting from defective zonule formation.
A rare developmental defect in which the heart is abnormally located partially or totally outside the THORAX. It is the result of defective fusion of the anterior chest wall. Depending on the location of the heart, ectopia cordis can be thoracic, thoracoabdominal, abdominal, and cervical.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
Incomplete rupture of the zonule with the displaced lens remaining behind the pupil. In dislocation, or complete rupture, the lens is displaced forward into the anterior chamber or backward into the vitreous body. When congenital, this condition is known as ECTOPIA LENTIS.
Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.
Monomeric subunits of primarily globular ACTIN and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Autosomal recessive inborn error of methionine metabolism usually caused by a deficiency of CYSTATHIONINE BETA-SYNTHASE and associated with elevations of homocysteine in plasma and urine. Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence of MENTAL RETARDATION, and a tendency to develop fibrosis of arteries, frequently complicated by CEREBROVASCULAR ACCIDENTS and MYOCARDIAL INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, p979)
A mass of histologically normal tissue present in an abnormal location.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The magnitude of INBREEDING in humans.
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
Genes that influence the PHENOTYPE only in the homozygous state.
The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.
Sheath of the eyeball consisting of fascia extending from the OPTIC NERVE to the corneal limbus.
The aperture in the iris through which light passes.

Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. (1/40)

Fibrillin is the principal structural component of the 10-12 nm diameter elastic microfibrils of the extracellular matrix. We have previously shown that both fibrillin molecules and assembled microfibrils are susceptible to degradation by serine proteases. In this study, we have investigated the potential catabolic effects of six matrix metalloproteinases (MMP-2, MMP-3, MMP-9, MMP-12, MMP-13 and MMP-14) on fibrillin molecules and on intact fibrillin-rich microfibrils isolated from ciliary zonules. Using newly synthesized recombinant fibrillin molecules, major cleavage sites within fibrillin-1 were identified. In particular, the six different MMPs generated a major degradation product of approximately 45 kDa from the N-terminal region of the molecule, whereas treatment of truncated, unprocessed and furin-processed C-termini also generated large degradation products. Introduction of a single ectopia lentis-causing amino acid substitution (E2447K; one-letter symbols for amino acids) in a calcium-binding epidermal growth factor-like domain, predicted to disrupt calcium binding, markedly altered the pattern of C-terminal fibrillin-1 degradation. However, the fragmentation pattern of a mutant fibrillin-1 with a comparable E-->K substitution in an upstream calcium-binding epidermal growth factor-like domain was indistinguishable from wild-type molecules. Ultrastructural examination highlighted that fibrillin-rich microfibrils isolated from ciliary zonules were grossly disrupted by MMPs. This is the first demonstration that fibrillin molecules and fibrillin-rich microfibrils are degraded by MMPs and that certain amino acid substitutions change the fragmentation patterns. These studies have important implications for physiological and pathological fibrillin catabolism and for loss of connective tissue elasticity in ageing and disease.  (+info)

Sensitivity of conformation sensitive gel electrophoresis in detecting mutations in Marfan syndrome and related conditions. (2/40)

OBJECTIVE: It has been firmly established that mutations in the gene for fibrillin 1, FBN1, cause Marfan syndrome (MFS). FBN1 mutations can also cause other phenotypes, such as ectopia lentis (EL) and familial isolated thoracic aortic aneurysm and dissection (FAA). When the clinical presentation is typical, diagnosis of MFS is usually easy to make. However, there can be a marked phenotypic variation between affected subjects even in one family, and making the diagnosis can be challenging, especially in childhood. The objective of this study was to test the sensitivity of conformation sensitive gel electrophoresis (CSGE) for detecting mutations in FBN1 in MFS and related phenotypes. DESIGN: Setting up CSGE analysis for the FBN1 gene and testing the method first by screening coded samples from 17 MFS patients with previously detected FBN1 mutations. We then used a test set consisting of 46 coded samples representing MFS, related phenotypes, and controls. RESULTS: Sixteen of the 17 known mutations were detected. Altogether 23 mutations were detected in a test set consisting of 46 coded samples representing MFS, related phenotypes, and controls. Nineteen of the mutations were novel. The mutation was detected in 18 of the 20 MFS patients and in one patient with familial EL, but not in a patient with sporadic MASS syndrome, any of the five sporadic annuloaortic ectasia (AAE) patients, or any of the 15 controls. A FBN1 mutation was detected in four members of a multigeneration family with AAE, however. CONCLUSIONS: These results indicate that CSGE is highly sensitive for the detection of mutations in FBN1, and that molecular diagnostics is a useful means of confirming clinical diagnoses of MFS and related disorders. Further careful investigations are needed, however, in order to correlate the interfamilial and intrafamilial clinical variabilities of fibrillinopathies and mutations in FBN1.  (+info)

Identification of FBN1 gene mutations in patients with ectopia lentis and marfanoid habitus. (3/40)

BACKGROUND: Marfan syndrome (MFS), inherited as an autosomal dominant trait, typically affects the cardiovascular, skeletal, and ocular systems. Ectopia lentis (EL) is a clinical manifestation of MFS, with stretching or disruption of the lenticular zonular filaments, leading to displacement of the lenses. EL, with or without minor skeletal changes, exists as an independent autosomal dominant phenotype linked to the same FBN1 locus. METHODS: A consecutive series of 11 patients, affected predominantly by EL, was analysed for FBN1 mutations using PCR, SSCA, and sequencing. RESULTS: Six mutations were identified, of which three are novel and one is recurrent in two patients, thus establishing a mutation incidence in this group of 7/11 (63%). CONCLUSION: The FBN1 variants reported are clustered in the first 15 exons of the gene, while FBN1 mutations reported in the literature are distributed throughout the entire length of the gene. A different type of FBN1 mutation presents in this group of patients, compared with MFS, with arginine to cysteine substitutions appearing frequently.  (+info)

Genetic linkage of the Marfan syndrome, ectopia lentis, and congenital contractural arachnodactyly to the fibrillin genes on chromosomes 15 and 5. The International Marfan Syndrome Collaborative Study. (4/40)

BACKGROUND: The large glycoprotein fibrillin is a structural component of elastin-containing microfibrils found in many tissues. The Marfan syndrome has been linked to the fibrillin gene on chromosome 15, but congenital contractural arachnodactyly, which shares some of the physical features of the syndrome, has been linked to the fibrillin gene on chromosome 5. METHODS: Using specific markers for the fibrillin genes, we performed genetic linkage analysis in 28 families with the Marfan syndrome and 8 families with four phenotypically related disorders--congenital contractural arachnodactyly (3 families), ectopia lentis (2), mitral-valve prolapse syndrome (2), and annuloaortic ectasia (1). RESULTS: Genetic linkage was established between the Marfan syndrome and only the fibrillin gene on chromosome 15, with a maximum lod score of 25.6 (odds for linkage, 10(25.6):1). Ectopia lentis was also linked to the fibrillin gene on chromosome 15, whereas congenital contractural arachnodactyly was linked to the fibrillin gene on chromosome 5. There was no linkage of mitral-valve prolapse to the fibrillin gene on chromosome 5; studies of chromosome 15 were not informative. Annuloaortic ectasia was not linked to either fibrillin gene. CONCLUSIONS: The Marfan syndrome appears to be caused by mutations in a single fibrillin gene on chromosome 15. Diagnosis of the Marfan syndrome by genetic linkage and analysis is now feasible in many families.  (+info)

Scleral suspension pars-plana lensectomy for ectopia lentis followed by suture fixation of intraocular lens. (5/40)

PURPOSE: To describe a simple technique of scleral suspension-pars plana lensectomy (SS-PPL) in acquired and congenital ectopia lentis and scleral fixation of intraocular lens (IOL). MATERIALS AND METHODS: Twenty eyes of 16 patients (12 unilateral and 4 bilateral cases of "essential familial lens subluxation") aged 10-40 years (mean 25 years) underwent SS-PPL with implantation of scleral fixated IOL. Indications for surgery were best-corrected visual acuity < 6/18, bisection of pupil by the lens, and lens-induced glaucoma. Prerequisites for SS-PPL were, visibility of part of the lens in the pupillary area and soft lens. RESULTS: Postoperative visual acuity ranged from 6/6 - 6/36. Lens tilt in 3 cases(15%) and small decentration in 2 cases(10%) were seen; however these did not seriously compromise the visual result. Scant vitreous bleeding on the first postoperative day was seen in 3 cases (15%). CONCLUSION: The advantages of the scleral suspension of subluxated lens prior to lensectomy include stabilization; it allows proper viewing of the lens, avoids injury to the iris and ciliary body during lensectomy and reduces the possibility of dislocation of the lens.  (+info)

Weill-Marchesani syndrome and secondary glaucoma associated with ectopia lentis. (6/40)

Weill-Marchesani syndrome (WMS) is a rare systemic connective tissue disorder with the systemic features of short stature, short and stubby hands and feet and stiff joints, especially in the hands. Occasionally, it is associated with heart defects and mental retardation. The main ocular features of WMS are microspherophakia (small and spherical crystalline lens), ectopia lentis (a displaced or malpositioned lens), severe myopia and glaucoma. Rare findings include asymmetric axial lengths associated with presenile vitreous liquefaction. A 14-year-old patient with WMS, who developed a secondary glaucoma and suffered visual loss from the ocular features of WMS, is described. The clinical findings and its successful management are also reported.  (+info)

Novel FBN1 mutations associated with predominant ectopia lentis and marfanoid habitus in Chinese patients. (7/40)

PURPOSE: To identify mutations in the fibrillin-1 gene (FBN1) and provide further information about genotype-phenotype correlations in Chinese patients with predominant ectopia lentis (EL) and marfanoid habitus. METHODS: Patients from seven Chinese families underwent complete physical, ophthalmic, and cardiovascular examination. Genomic DNA was extracted from leukocytes of peripheral blood from the patients. The 65 exons and flanking intronic sequences of FBN1 were amplified by polymerase chain reaction (PCR) and screened for mutation by direct DNA sequencing. RESULTS: Three novel mutations, c.203G>T in exon 2, c.502T>C in exon 5, and c.2096G>C in exon 16 as well as four known mutations, c.364C>T in exon 4, c.1633C>T in exon 13, c.1879C>T in exon 15, and c.4588C>T in exon37, were identified in FBN1. CONCLUSIONS: We identified three novel mutations and four known mutations in FBN1 and found cysteine substitution highly related to EL. These results expand the mutation spectrum in FBN1 and enrich our knowledge of genotype-phenotype correlations due to FBN1 mutations. To our knowledge, this is the first report of cysteine residue loss in the unique NH2-terminal domain of fibrillin-1.  (+info)

Ectopia lentis et pupillae: the genetic aspects and differential diagnosis. (8/40)

Two sib pairs and a fifth child are described with autosomal recessive ectopia lentis et pupillae. Patients with this disorder need regular ophthalmic review, but do not have the skeletal and metabolic complications associated with other syndromes with ectopia lentis.  (+info)

Ectopia lentis is a medical term that refers to the displacement or malpositioning of the lens in the eye. The lens, which is normally located behind the iris and held in place by tiny fibers called zonules, can become dislocated due to various reasons such as genetic disorders like Marfan syndrome, trauma, or other ocular diseases.

When the lens becomes displaced, it can cause a variety of symptoms including blurry vision, double vision, sensitivity to light, and distorted images. In some cases, ectopia lentis may be asymptomatic and only discovered during a routine eye examination. Treatment for ectopia lentis depends on the severity of the displacement and any associated symptoms. In mild cases, no treatment may be necessary, while in more severe cases, surgery may be required to reposition or remove the lens and replace it with an artificial one.

Ectopia Cordis is a rare congenital condition in which the heart or a portion of it is located outside the chest wall during fetal development. It is caused by the failure of the anterior chest wall and ventricular septum to close properly, resulting in the heart being exposed on the exterior of the body or covered only by a thin layer of skin. This condition is often associated with other congenital defects, such as cardiac abnormalities, chromosomal anomalies, and genetic syndromes. The severity of ectopia cordis can vary widely, from mild cases where the heart is partially outside the chest to severe cases where it is completely exposed. Treatment typically involves surgical correction, which can be complex due to the presence of other associated defects.

Marfan syndrome is a genetic disorder that affects the body's connective tissue. Connective tissue helps to strengthen and support various structures in the body, including the skin, ligaments, blood vessels, and heart. In Marfan syndrome, the body produces an abnormal amount of a protein called fibrillin-1, which is a key component of connective tissue. This leads to problems with the formation and function of connective tissue throughout the body.

The most serious complications of Marfan syndrome typically involve the heart and blood vessels. The aorta, which is the large artery that carries blood away from the heart, can become weakened and stretched, leading to an increased risk of aortic dissection or rupture. Other common features of Marfan syndrome include long, thin fingers and toes; tall stature; a curved spine; and eye problems such as nearsightedness and lens dislocation.

Marfan syndrome is usually inherited in an autosomal dominant pattern, which means that a child has a 50% chance of inheriting the gene mutation from a parent who has the condition. However, about 25% of cases are the result of a new mutation and occur in people with no family history of the disorder. There is no cure for Marfan syndrome, but treatment can help to manage the symptoms and reduce the risk of complications.

Lens subluxation, also known as lens dislocation or ectopia lentis, is a condition where the lens of the eye becomes partially or completely displaced from its normal position. The lens is held in place by tiny fibers called zonules, which can become weakened or broken due to various reasons such as genetic disorders (like Marfan syndrome, homocystinuria, and Weill-Marchesani syndrome), trauma, inflammation, or cataract surgery complications. This displacement can lead to symptoms like blurry vision, double vision, sensitivity to light, or the appearance of a shadow in the peripheral vision. In some cases, lens subluxation may not cause any noticeable symptoms and can be discovered during routine eye examinations. Treatment options depend on the severity and underlying cause of the subluxation and may include eyeglasses, contact lenses, or surgical intervention to remove and replace the displaced lens with an intraocular lens (IOL).

A pupil disorder refers to any abnormality or condition affecting the size, shape, or reactivity of the pupils, the circular black openings in the center of the eyes through which light enters. The pupil's primary function is to regulate the amount of light that reaches the retina, adjusting its size accordingly.

There are several types of pupil disorders, including:

1. Anisocoria: A condition characterized by unequal pupil sizes in either one or both eyes. This may be caused by various factors, such as nerve damage, trauma, inflammation, or medication side effects.

2. Horner's syndrome: A neurological disorder affecting the autonomic nervous system, resulting in a smaller pupil (miosis), partial eyelid droop (ptosis), and decreased sweating (anhidrosis) on the same side of the face. It is caused by damage to the sympathetic nerve pathway.

3. Adie's tonic pupil: A condition characterized by a dilated, poorly reactive pupil due to damage to the ciliary ganglion or short ciliary nerves. This disorder usually affects one eye and may be associated with decreased deep tendon reflexes in the affected limbs.

4. Argyll Robertson pupil: A condition where the pupils are small, irregularly shaped, and do not react to light but constrict when focusing on nearby objects (accommodation). This disorder is often associated with neurosyphilis or other brainstem disorders.

5. Pupillary dilation: Abnormally dilated pupils can be a sign of various conditions, such as drug use (e.g., atropine, cocaine), brainstem injury, Adie's tonic pupil, or oculomotor nerve palsy.

6. Pupillary constriction: Abnormally constricted pupils can be a sign of various conditions, such as Horner's syndrome, Argyll Robertson pupil, drug use (e.g., opioids, pilocarpine), or oculomotor nerve palsy.

7. Light-near dissociation: A condition where the pupils do not react to light but constrict when focusing on nearby objects. This can be seen in Argyll Robertson pupil and Adie's tonic pupil.

Prompt evaluation by an ophthalmologist or neurologist is necessary for accurate diagnosis and management of these conditions.

Microfilament proteins are a type of structural protein that form part of the cytoskeleton in eukaryotic cells. They are made up of actin monomers, which polymerize to form long, thin filaments. These filaments are involved in various cellular processes such as muscle contraction, cell division, and cell motility. Microfilament proteins also interact with other cytoskeletal components like intermediate filaments and microtubules to maintain the overall shape and integrity of the cell. Additionally, they play a crucial role in the formation of cell-cell junctions and cell-matrix adhesions, which are essential for tissue structure and function.

Thrombospondins (TSPs) are a family of multifunctional glycoproteins that are involved in various biological processes, including cell adhesion, migration, proliferation, differentiation, and angiogenesis. They were initially identified as calcium-binding proteins that are secreted by platelets during blood clotting (thrombosis), hence the name thrombospondin.

There are five members in the TSP family, designated as TSP-1 to TSP-5, and they share a common structure consisting of several domains, including an N-terminal domain, a series of type 1 repeats, a type 2 (von Willebrand factor C) repeat, a type 3 repeat, and a C-terminal domain.

TSP-1 and TSP-2 are secreted proteins that have been extensively studied for their roles in the regulation of angiogenesis, the process of new blood vessel formation. They bind to various extracellular matrix components, growth factors, and cell surface receptors, and can either promote or inhibit angiogenesis depending on the context.

TSP-3 to TSP-5 are expressed in a variety of tissues and play roles in cell adhesion, migration, and differentiation. They have been implicated in various pathological conditions, including cancer, fibrosis, and neurodegenerative diseases.

Overall, thrombospondins are important regulators of extracellular matrix dynamics and cell-matrix interactions, and their dysregulation has been associated with a variety of diseases.

Homocystinuria is a genetic disorder characterized by the accumulation of homocysteine and its metabolites in the body due to a deficiency in the enzyme cystathionine beta-synthase (CBS). This enzyme is responsible for converting homocysteine to cystathionine, which is a critical step in the metabolic pathway that breaks down methionine.

As a result of this deficiency, homocysteine levels in the blood increase and can lead to various health problems, including neurological impairment, ocular abnormalities (such as ectopia lentis or dislocation of the lens), skeletal abnormalities (such as Marfan-like features), and vascular complications.

Homocystinuria can be diagnosed through newborn screening or by measuring homocysteine levels in the blood or urine. Treatment typically involves a low-methionine diet, supplementation with vitamin B6 (pyridoxine), betaine, and/or methylcobalamin (a form of vitamin B12) to help reduce homocysteine levels and prevent complications associated with the disorder.

A choristoma is a type of growth that occurs when normally functioning tissue is found in an abnormal location within the body. It is not cancerous or harmful, but it can cause problems if it presses on surrounding structures or causes symptoms. Choristomas are typically congenital, meaning they are present at birth, and are thought to occur due to developmental errors during embryonic growth. They can be found in various organs and tissues throughout the body, including the brain, eye, skin, and gastrointestinal tract.

I must clarify that the term "pedigree" is not typically used in medical definitions. Instead, it is often employed in genetics and breeding, where it refers to the recorded ancestry of an individual or a family, tracing the inheritance of specific traits or diseases. In human genetics, a pedigree can help illustrate the pattern of genetic inheritance in families over multiple generations. However, it is not a medical term with a specific clinical definition.

Consanguinity is a medical and genetic term that refers to the degree of genetic relationship between two individuals who share common ancestors. Consanguineous relationships exist when people are related by blood, through a common ancestor or siblings who have children together. The closer the relationship between the two individuals, the higher the degree of consanguinity.

The degree of consanguinity is typically expressed as a percentage or fraction, with higher values indicating a closer genetic relationship. For example, first-degree relatives, such as parents and children or full siblings, share approximately 50% of their genes and have a consanguinity coefficient of 0.25 (or 25%).

Consanguinity can increase the risk of certain genetic disorders and birth defects in offspring due to the increased likelihood of sharing harmful recessive genes. The risks depend on the degree of consanguinity, with closer relationships carrying higher risks. It is important for individuals who are planning to have children and have a history of consanguinity to consider genetic counseling and testing to assess their risk of passing on genetic disorders.

In medical terms, the iris refers to the colored portion of the eye that surrounds the pupil. It is a circular structure composed of thin, contractile muscle fibers (radial and circumferential) arranged in a regular pattern. These muscles are controlled by the autonomic nervous system and can adjust the size of the pupil in response to changes in light intensity or emotional arousal. By constricting or dilating the iris, the amount of light entering the eye can be regulated, which helps maintain optimal visual acuity under various lighting conditions.

The color of the iris is determined by the concentration and distribution of melanin pigments within the iris stroma. The iris also contains blood vessels, nerves, and connective tissue that support its structure and function. Anatomically, the iris is continuous with the ciliary body and the choroid, forming part of the uveal tract in the eye.

Recessive genes refer to the alleles (versions of a gene) that will only be expressed when an individual has two copies of that particular allele, one inherited from each parent. If an individual inherits one recessive allele and one dominant allele for a particular gene, the dominant allele will be expressed and the recessive allele will have no effect on the individual's phenotype (observable traits).

Recessive genes can still play a role in determining an individual's genetic makeup and can be passed down through generations even if they are not expressed. If two carriers of a recessive gene have children, there is a 25% chance that their offspring will inherit two copies of the recessive allele and exhibit the associated recessive trait.

Examples of genetic disorders caused by recessive genes include cystic fibrosis, sickle cell anemia, and albinism.

A LOD (Logarithm of Odds) score is not a medical term per se, but rather a statistical concept that is used in genetic research and linkage analysis to determine the likelihood of a gene or genetic marker being linked to a particular disease or trait. The LOD score compares the odds of observing the pattern of inheritance of a genetic marker in a family if the marker is linked to the disease, versus the odds if the marker is not linked. A LOD score of 3 or higher is generally considered evidence for linkage, while a score of -2 or lower is considered evidence against linkage.

The anterior chamber is the front portion of the eye, located between the cornea (the clear front "window" of the eye) and the iris (the colored part of the eye). It is filled with a clear fluid called aqueous humor that provides nutrients to the structures inside the eye and helps maintain its shape. The anterior chamber plays an important role in maintaining the overall health and function of the eye.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Miotics, also known as parasympathomimetics or cholinergic agents, are a class of medications that stimulate the parasympathetic nervous system. They work by activating muscarinic receptors, which are found in various organs throughout the body, including the eye. In the eye, miotics cause contraction of the circular muscle of the iris, resulting in pupillary constriction (miosis). This action can help to reduce intraocular pressure in patients with glaucoma.

Miotics may also have other effects on the eye, such as accommodation (focusing) and decreasing the production of aqueous humor. Some examples of miotics include pilocarpine, carbachol, and ecothiopate. It's important to note that the use of miotics can have side effects, including blurred vision, headache, and brow ache.

The Tenon's capsule, also known as the fibrous layer of the sclera or the episcleral fascia, is a thick, fibrous sheath that encloses the eyeball's outer coat, the sclera. It starts at the limbus (the junction between the cornea and sclera) and extends backward to merge with the sheaths of the extraocular muscles.

The Tenon's capsule functions as a protective layer for the eye and allows for smooth movement by reducing friction between the eyeball and its surrounding tissues. It also serves as a potential space for the accumulation of fluid or inflammatory cells during ocular diseases, leading to conditions such as tenonitis or tenosynovitis.

A pupil, in medical terms, refers to the circular opening in the center of the iris (the colored part of the eye) that allows light to enter and reach the retina. The size of the pupil can change involuntarily in response to light intensity and emotional state, as well as voluntarily through certain eye exercises or with the use of eye drops. Pupillary reactions are important in clinical examinations as they can provide valuable information about the nervous system's functioning, particularly the brainstem and cranial nerves II and III.

GeneReviews/NCBI/NIH/UW entry on ADAMTSL4-Related Eye Disorders, Autosomal Recessive Isolated Ectopia Lentis, Ectopia Lentis et ... Ectopia lentis is a displacement or malposition of the eye's crystalline lens from its normal location. A partial dislocation ... Although observed in humans and cats, ectopia lentis is most commonly seen in dogs. Ciliary zonules normally hold the lens in ... "Ectopia Lentis". eMedicine.com. November 24, 2004. Peter Nicholas Robinson; Maurice Godfrey (2004). Marfan syndrome: a primer ...
... is an extremely rare genetic disorder which is characterized by congenital ... "OMIM Entry - 110150 - BLEPHAROPTOSIS, MYOPIA, AND ECTOPIA LENTIS". omim.org. Retrieved 2022-05-23. v t e (Orphaned articles ... Gillum, William N.; Anderson, Richard L. (1982-02-01). "Dominantly Inherited Blepharoptosis, High Myopia, and Ectopia Lentis". ... presence of ectopia lentis, and severe near-sightedness (myopia). It affects (and consequently decreases) the relative strength ...
... is a rare hereditary disorder which is characterized by ectopia lentis (that is; a ... "Ectopia Lentis - EyeWiki". eyewiki.aao.org. Archived from the original on 1 February 2022. Retrieved 18 July 2022. "Ectopia ... "Orphanet: Isolated ectopia lentis". www.orpha.net. Archived from the original on 14 June 2022. Retrieved 18 July 2022. ( ... "Entry - #225100 - ECTOPIA LENTIS 2, ISOLATED, AUTOSOMAL RECESSIVE; ECTOL2 - OMIM". omim.org. Archived from the original on 21 ...
A subluxation of the lens within the eye is called ectopia lentis, wherein it is displaced or malpositioned. Subluxated lenses ... Eifrig, Charles W (July 22, 2011). Roy Sr, Hampton (ed.). "Ectopia Lentis". Medscape. WebMD LLC. Retrieved March 12, 2013. ...
Ectopia lentis "Spherophakia". University of Arizona. Retrieved 2012-08-20. Nirankari, M.S.; Maudgal, M.C. (1959). "Microphakia ...
IKBKG Ectopia lentis, familial; 129600; FBN1 Ectopia lentis, isolated, autosomal recessive; 225100; ADAMTSL4 Ectrodactyly, ...
... is associated with ectopia lentis (a displacement or malposition of the eye's crystalline lens) in humans. ... Eifrig, Charles W (10 March 2015). "Ectopia Lentis Clinical Presentation: Causes". Medscape. WebMD LLC. Retrieved 9 December ...
Adès LC, Holman KJ, Brett MS, Edwards MJ, Bennetts B (April 2004). "Ectopia lentis phenotypes and the FBN1 gene". American ...
Ectopia lentis, a congenital condition, also affects this breed. Although not currently well-documented in the Teddy Roosevelt ...
Homocystinuria is the second most common cause of heritable ectopia lentis. Homocystinuria is an autosomal recessive metabolic ...
Ectopia lentis is the displacement of the lens from its normal position. Aphakia is the absence of the lens from the eye. ... By nine weeks into human development, the lens is surrounded and nourished by a net of vessels, the tunica vasculosa lentis, ... focusing is instead achieved by moving the lens forwards or backwards within the eye using a muscle called the retractor lentus ...
Ectopia lentis can be treated, as artificial lenses can be surgically implanted. In addition, surgery can address glaucoma and ... 2 AND ectopia lentis Aortic root Z-score ≥ 2 AND an FBN1 mutation Aortic root Z-score ≥ 2 AND a systemic score* > 7 points ... Ectopia lentis Systemic score* ≥ 7 Aortic root Z-score ≥ 2 Points for systemic score: Wrist AND thumb sign = 3 (wrist OR thumb ... Ectopia lentis AND an FBN1 mutation with known aortic pathology In the presence of a family history of MFS (as defined above): ...
It may be associated with high myopia or ectopia lentis, among other conditions. Medical or surgical intervention may be ...
It is characterized by aniridia, ectopia lentis, abnormal upper incisors and intellectual disability. Not a lot of research has ... Zamzam AM, Sheriff SM, Phillips CI (1988). "Aniridia, ectopia lentis, abnormal upper incisors and mental retardation--an ...
"Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome". Nat. Genet. 6 (1): 64-9 ...
... ectopia lentis, glaucoma, spherophakia, and short stature". American Journal of Human Genetics. 85 (5): 558-568. doi:10.1016/j. ...
Ectopia lentis is a displacement or malposition of the eye's crystalline lens from its normal location. The displace lens leads ...
Lens luxation, also known as ectopia lentis is the most common hereditary disorder in Jack Russell terriers. Even so, this ... These issues can include hereditary cataracts, ectopia lentis, congenital deafness, patellar luxation, ataxia, myasthenia ...
In 1856 he coined the term "ectopia lentis", when describing a patient who had congenital lens dislocation. He was the author ... eMedicine Ectopia Lentis (Articles with FAST identifiers, Articles with ISNI identifiers, Articles with VIAF identifiers, ...
... ectopia lentis), as well as other ocular defects. Due to such abnormalities, affected individuals may have varying degrees of ...
... such as that caused by a corneal foreign body or keratitis Ectopia lentis Endophthalmitis Eye trauma caused by disease, injury ...
... animals Coccidia Cowpox Cryptosporidiosis Cuterebriasis Diabetes in cats Dirofilaria immitis Dry eye syndrome Ectopia lentis ...
... autosomal recessive Ectodermal dysplasia Ectodermic dysplasia anhidrotic cleft lip Ectopia cordis Ectopia lentis Ectopia ...
Ectopia lentis - in contrast to Marfan syndrome which features upward ectopia lentis, downward dislocation is the typical ...
... can cause Cushing's syndrome Ectopia lentis, the displacement of the crystalline lens of the eye Neuronal ectopia Ectopic ... An ectopia (/ɛkˈtoʊpiə/) is a displacement or malposition of an organ or other body part, which is then referred to as ectopic ... 2019). "Ectopia". Kendig's Disorders of the Respiratory Tract in Children (9 ed.). Philadelphia, Pennsylvania: Elsiver. pp. ... distichia Ectopia cordis, the displacement of the heart outside the body during fetal development Ectopic enamel, a tooth ...
... ectopia lentis MeSH C16.131.384.480 - hydrophthalmos MeSH C16.131.384.666 - microphthalmos MeSH C16.131.384.784 - retinal ...
Blepharoptosis aortic anomaly Blepharoptosis cleft palate ectrodactyly dental anomalies Blepharoptosis-myopia-ectopia lentis ...
... isolated ectopia lentis, MASS phenotype, and Shprintzen-Goldberg syndrome. "Acromicric dysplasia , Genetic and Rare Diseases ...
... isolated ectopia lentis, MASS phenotype, and Shprintzen-Goldberg syndrome. Scleroderma Self-healing papular mucinosis List of ...
... ectopia lentis and heart complications such as mitral valve prolapse and aortic enlargement increasing the likelihood of aortic ...
GeneReviews/NCBI/NIH/UW entry on ADAMTSL4-Related Eye Disorders, Autosomal Recessive Isolated Ectopia Lentis, Ectopia Lentis et ... Ectopia lentis is a displacement or malposition of the eyes crystalline lens from its normal location. A partial dislocation ... Although observed in humans and cats, ectopia lentis is most commonly seen in dogs. Ciliary zonules normally hold the lens in ... "Ectopia Lentis". eMedicine.com. November 24, 2004. Peter Nicholas Robinson; Maurice Godfrey (2004). Marfan syndrome: a primer ...
Isolated ectopia lentis is a condition that affects the eyes, specifically the positioning of the lens. Explore symptoms, ... Genetic Testing Registry: Ectopia lentis 2, isolated, autosomal recessive *Genetic Testing Registry: Ectopia lentis 1, isolated ... The prevalence of isolated ectopia lentis is unknown. In Denmark, an estimated 6.4 per 100,000 individuals have ectopia lentis ... medlineplus.gov/genetics/condition/isolated-ectopia-lentis/ Isolated ectopia lentis. ...
Berryat described the first reported case of lens dislocation in 1749, and Stellwag subsequently coined the term ectopia lentis ... Ectopia lentis is defined as displacement or malposition of the crystalline lens of the eye. ... encoded search term (Ectopia Lentis) and Ectopia Lentis What to Read Next on Medscape ... Ectopia Lentis Differential Diagnoses. Updated: Jun 06, 2018 * Author: Charles W Eifrig, MD; Chief Editor: Hampton Roy, Sr, MD ...
Isolated ectopia lentis is a condition that affects the eyes, specifically the positioning of the lens. Explore symptoms, ... Genetic Testing Registry: Ectopia lentis 2, isolated, autosomal recessive *Genetic Testing Registry: Ectopia lentis 1, isolated ... The prevalence of isolated ectopia lentis is unknown. In Denmark, an estimated 6.4 per 100,000 individuals have ectopia lentis ... medlineplus.gov/genetics/condition/isolated-ectopia-lentis/ Isolated ectopia lentis. ...
... and simple ectopia lentis are the most common causes of pediatric lens subluxation. Many patients are best treated with a ... Management of ectopia lentis in children D E Neely et al. Ophthalmol Clin North Am. 2001 Sep. ... Management of ectopia lentis in children D E Neely 1 , D A Plager ... Ectopia lentis surgery in Marfans syndrome: from "couching" to the use of intracapsular tension rings. Dogăroiu AC, Dogăroiu C ...
Learn about diagnosis and specialist referrals for Isolated ectopia lentis. ... Isolated ectopia lentis. Other Names: Ectopia lentis syndrome; Familial ectopia lentisEctopia lentis syndrome; Familial ectopia ... Because Isolated ectopia lentis is considered a genetic disease, you may want to ask your health care team if genetic testing ... Because Isolated ectopia lentis is considered a genetic disease, you may want to ask your health care team if genetic testing ...
signs and symptoms of Ectopia lentis, isolated may vary on an individual basis for each patient. Only your doctor can provide ... ADAMTSL4-associated isolated ectopia lentis: Further patients, novel mutations and a detailed phenotype description ... ADAMTSL4-related ectopia lentis: A case of pseudodominance with an asymptomatic parent ... adequate diagnosis of any signs or symptoms and whether they are indeed Ectopia lentis, isolated symptoms. ...
Ectopia Lentis in a Patient With Marfan Syndrome. Sometimes, the technology a surgeon thinks would be of greatest benefit is ... Ectopia lentis occurs in 50% to 80% of patients with MFS, and it is often the presenting sign. In such situations, vision is ... Ectopia lentis and lens coloboma of any degree are major criteria. At least two of the following minor criteria must be present ... I find a laser capsulotomy to be superior to a manual approach in patients with ectopia lentis from MFS, and I now recommend ...
A bilateral, autosomal recessive, congenital anomaly where luxation or subluxation of the lens occurs, associated with other ocu
5 mL whole blood (EDTA). Send us the clinical information. Check for other samples: https://ja.cat/OQGD2 Consent Form: https://ja.cat/VJ6sn. ...
WHAT IS ECTOPIA LENTIS?. Ectopia lentis is when the lens inside the eye is not in the right spot, it is also called lens ... 1: Subluxated lens (ectopia lentis). The lens is seen in the pupil (dark spot in the center of the colored part of the eye). ... Some of the more common problems in people with Marfan syndrome are ectopia lentis (when the lens of the eye is not in the ... This movement of the lens is caused by weakness in the connective tissue that holds the lens in place (zonules). Ectopia lentis ...
... is called ectopia lentis. Trauma is a usual cause but hereditary syndromes can be associated at times. ... Ectopia lentis is the fancy term for dislocation of the lens inside your eye. Heres how it can happen. ... The symptom of ectopia lentis is blurred vision. The degree of the blurring depends on how dislocated the lens is and the type ... Ectopia lentis is the medical term for the dislocation or displacement of the eyes natural lens. A dislocated lens is usually ...
Ectopia Lentis * 2001/viewarticle/985983. COVID Isolated People. Long COVID Makes It Worse ...
Hyperlysinemia is associated with ectopia lentis (a displacement or malposition of the eyes crystalline lens) in humans. ... Eifrig, Charles W (10 March 2015). "Ectopia Lentis Clinical Presentation: Causes". Medscape. WebMD LLC. Retrieved 9 December ...
Ectopia Lentis * Ectropion * Entropion * Epiretinal Membrane * Esotropia * Eye Cancer * Eye Complications Of Wegener ...
CRYSTALLINE LENS 74 .. .. Changes, lens, punctate--See Opacity, lens 74 .. .. Ectopia lentis--See Dislocation, lens 74 .. .. ... 71 19 00 Tunica vasculosa lentis, iris 71 42 40 Foreign body, iris NOS (metallic) 71 42 49 Foreign body, iris, retained ( ...
Hereditary ectopia lentis].. Neuhann TM. Klin Monbl Augenheilkd; 2015 Mar; 232(3):259-65. PubMed ID: 25654236. [TBL] ...
OMIM:182212: Ectopia lentis, familial ; MASS syndrome. OMIM:604308: Coagulation factor VII (P08709) (SMART). OMIM:227500: ...
Jones W, Rodriguez J, Bassnett S. Targeted deletion of fibrillin-1 in the mouse eye results in ectopia lentis and other ocular ... By age 3 months, all mice with fibrillin-deficient NPCE had experienced ectopia lentis. And they exhibited other Marfan-like ... a condition called ectopia lentis. People with Marfan syndrome have increased risk of glaucoma, cataract, and high myopia. ...
... ectopia lentis (abnormal position of the lens), and glaucoma, which can lead to blindness. Height of adult males is 142-169 cm ... Ectopia Lentis. Ectopia lentis may occur in the conditions listed in Table 4. All, however, are clinically distinct from Weill- ... Li J, Jia X, Li S, Fang S, Guo X. Mutation survey of candidate genes in 40 Chinese patients with congenital ectopia lentis. Mol ... Ectopia lentis et pupilae (OMIM 225200). AR. Ectopic pupil, flat-appearing iris, cataracts. ...
OMIM:182212: Ectopia lentis, familial ; MASS syndrome. OMIM:604308: Coagulation factor VII (P08709) (SMART). OMIM:227500: ...
OMIM:182212: Ectopia lentis, familial ; MASS syndrome. OMIM:604308: Coagulation factor VII (P08709) (SMART). OMIM:227500: ...
Ocular features mainly involve ectopia lentis, which is observed in around 80% of MFS patients. Ectopia lentis is characterized ... Interestingly, all patients in this family developed ectopia lentis, had high myopia and glaucoma. In literature it has been ... Interestingly all affected family members presented with ectopia lentis, myopia and glaucoma, but lacked the cardinal ... All patients, including 4 young children, developed ectopia lentis, myopia and glaucoma. However, no cardiovascular system ...
Ectopia lentis, which happens when the lens of the eyes shifts, often leading to changes in vision. ...
Ectopia lentis, which happens when the lens of the eyes shifts, often leading to changes in vision. ...
Thsd4 interacts with fibrillin-1 and promotes fibril formation [63]. Mutations in Thsd4 cause ectopia lentis, which is ... A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. Am J Hum Genet. 2009; 84:274-8. [PMID: ... Although every attempt was made to physically remove the tunica vasculosa lentis, the lens epithelial fraction most likely ...
All individuals presented with eye anomalies, mainly spherophakia (42/61) and ectopia lentis (39/61). Short stature was present ...
Ectopia Lentis. *. Cornea. Atypical Keratitis. *. Cover Focus. Fragmentation Techniques for Different Lens Densities ...
  • People with ectopia lentis et pupillae have eye and vision problems similar to those with isolated ectopia lentis (described above), including nearsightedness (myopia), farsightedness (hyperopia), or an irregular curvature of the front of the eye (astigmatism). (medlineplus.gov)
  • Ectopia lentis, associated with late diagnosis of CbS deficiency, was identified as the major risk factor for other ocular complications, including strabismus (24%), dense cataract (21%), acute pupillary block glaucoma (19%), retinal detachment (15%), and unilateral blindness (18%) [32]. (hcusupport.com)
  • Berryat described the first reported case of lens dislocation in 1749, and Stellwag subsequently coined the term ectopia lentis in 1856 (describing a patient with congenital lens dislocation). (medscape.com)
  • When congenital, this condition is known as ECTOPIA LENTIS. (sdsu.edu)
  • Ectopia lentis is, of course, the classical ocular feature and is often if not always congenital with some progression. (arizona.edu)
  • In humans, a number of systemic conditions are associated with ectopia lentis: More common: Marfan syndrome (upward and outward) Homocystinuria (downward and inwards) Weill-Marchesani syndrome Sulfite oxidase deficiency Molybdenum cofactor deficiency Hyperlysinemia Less common: Ehlers-Danlos syndrome Crouzon disease Refsum syndrome Kniest syndrome Mandibulofacial dysostosis Sturge-Weber syndrome Conradi syndrome Pfaundler syndrome Pierre Robin syndrome Wildervanck syndrome Sprengel deformity List of systemic diseases with ocular manifestations Ketring, Kerry I. (2006). (wikipedia.org)
  • Omulecki W, Wilczynski M, Gerkowicz M. Management of bilateral ectopia lentis et pupillae syndrome. (medscape.com)
  • Ectopia lentis can also be classified as syndromic, when it is part of a syndrome that affects multiple parts of the body. (medlineplus.gov)
  • Ectopia lentis is a common feature of genetic syndromes such as Marfan syndrome and Weill-Marchesani syndrome . (medlineplus.gov)
  • This consecutive retrospective case series sought to predict axial length (AL) growth in patients with Marfan syndrome (MFS) and ectopia lentis (EL). (crstoday.com)
  • A consecutive retrospective case series found that axial length (AL) growth followed a logarithmic pattern and ceased at about 15 years of age in patients with Marfan syndrome (MFS) and ectopia lentis. (crstoday.com)
  • Ectopia lentis in Marfan's syndrome. (umassmed.edu)
  • Fibrillin-1 mutations have also been found in patients who do not fulfil clinical criteria for the diagnosis of Marfan syndrome, but have related disorders of connective tissue, such as isolated ectopia lentis, familial aortic aneurysm, and Marfan-like skeletal abnormalities, so that Marfan syndrome may be regarded as one of a range of type 1 fibrillinopathies. (bmj.com)
  • He had bilateral ectopia lentis with rhegmatogenous retinal detachment sparing the macula in the left eye. (nepjol.info)
  • Many patients develop ectopia lentis (lens subluxation), intellectual disability, and osteoporosis. (msdmanuals.com)
  • Mutations in the FBN1 or ADAMTSL4 gene cause isolated ectopia lentis. (medlineplus.gov)
  • ADAMTSL4- associated ectopia lentis is a rare autosomal recessive condition that is primarily associated with crystalline lens displacement. (molvis.org)
  • A cross-sectional case study series of four individuals with biallelic pathogenic or likely pathogenic ADAMTSL4 variants was performed alongside a literature review of individuals with ADAMTSL4 -associated ectopia lentis on September 29, 2021. (molvis.org)
  • The clinical phenotype of ADAMTSL4 -associated ectopia lentis was summarized and expanded. (molvis.org)
  • In this study, we describe a series of four previously unreported individuals from three pedigrees and summarize the phenotypic spectrum of ADAMTSL4 -associated ectopia lentis. (molvis.org)
  • At least 15 mutations in the ADAMTSL4 gene have been found to cause isolated ectopia lentis. (medlineplus.gov)
  • Some ADAMTSL4 gene mutations cause an eye condition called ectopia lentis et pupillae. (medlineplus.gov)
  • Similar to isolated ectopia lentis, the ADAMTSL4 gene mutations that cause ectopia lentis et pupillae lead to decreased production of microfibrils or the formation of impaired microfibrils, which prevents the proper anchoring of certain structures in the eyes. (medlineplus.gov)
  • Christensen AE, Fiskerstrand T, Knappskog PM, Boman H, Rodahl E. A novel ADAMTSL4 mutation in autosomal recessive ectopia lentis et pupillae. (medlineplus.gov)
  • Its diverse clinical expression may include ectopia lentis, skeletal abnormalities, mental retardation, and premature arteriosclerosis and thrombosis. (nih.gov)
  • When isolated ectopia lentis is caused by mutations in the FBN1 gene, it is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
  • Mutations in FBN1 have also been found in cases with isolated autosomal dominant ectopia lentis ( 129600 ). (arizona.edu)
  • Abnormal development of these zonules can lead to primary ectopia lentis, usually a bilateral condition. (wikipedia.org)
  • Clark CC. Ectopia lentis: a pathologic and clinical study. (medscape.com)
  • Purpose: To report a small series of pediatric patients with ectopia lentis that underwent limbal-approach lensectomy and vitrectomy and scleral-fixated intraocular lens implantation and to review the literature on the topic of surgical management of ectopia lentis. (wustl.edu)
  • In the absence of trauma, ectopia lentis should evoke suspicion for concomitant hereditary systemic disease or associated ocular disorders. (medscape.com)
  • Patients with heritable conditions associated with ectopia lentis may have other systemic complications. (medscape.com)
  • Conclusion: Surgical intervention for ectopia lentis via vitrectomy techniques yields good result. (wustl.edu)
  • Ectopia lentis is a displacement or malposition of the eye's crystalline lens from its normal location. (wikipedia.org)
  • Ectopia lentis may cause marked visual disturbance, which varies with the degree of lens displacement and the underlying etiologic abnormality. (medscape.com)
  • As a result, there is a reduction in filaments to anchor the lens in its central position at the front of the eye, leading to its displacement and the vision problems characteristic of isolated ectopia lentis. (medlineplus.gov)
  • Hyperlysinemia is associated with ectopia lentis (a displacement or malposition of the eye's crystalline lens) in humans. (wikipedia.org)
  • Mutations in the same gene have also been found in the autosomal recessive form of isolated ectopia lentis ( 225100 ). (arizona.edu)
  • In the eye, the mutations weaken the zonule fibers to the point of breaking and letting go of the lens, a condition called ectopia lentis. (nih.gov)
  • The natural history of developing ectopia lentis in classical homocystinuria is such that 70% had ectopia lentis by age 10 years [9]. (hcusupport.com)
  • Those patients who have trauma-associated ectopia lentis may have other more life-threatening complications (depending on the severity of the trauma). (medscape.com)
  • Patients with ectopia lentis associated with a heritable condition need to be educated on the importance of following up with a primary care physician to rule out life-threatening disorders. (medscape.com)
  • I have ectopia lentis due to a genetic cause, and I am myopic. (icliniq.com)
  • Disruption or dysfunction of the zonular fibers of the lens, regardless of cause (trauma or heritable condition), is the underlying pathophysiology of ectopia lentis. (medscape.com)
  • Ectopia lentis is a rare condition. (medscape.com)
  • Isolated ectopia lentis is a condition that affects the eyes, specifically the positioning of the lens. (medlineplus.gov)
  • Konradsen T, Kugelberg M, Zetterström C. Visual outcomes and complications in surgery for ectopia lentis in children. (medscape.com)
  • The most common cause of ectopia lentis is trauma , which accounts for nearly one half of all cases of lens dislocation . (medscape.com)
  • In Denmark, an estimated 6.4 per 100,000 individuals have ectopia lentis, but a large proportion of these cases (about 75 percent) are syndromic. (medlineplus.gov)
  • In people with isolated ectopia lentis, the lens in one or both eyes is not centrally positioned as it should be but is off-center (displaced). (medlineplus.gov)
  • The displaced lens cannot focus light correctly, contributing to the vision problems that are common in people with isolated ectopia lentis. (medlineplus.gov)
  • This graph shows the total number of publications written about "Ectopia Lentis" by people in this website by year, and whether "Ectopia Lentis" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Ectopia Lentis" by people in Profiles. (umassmed.edu)
  • Ectopia lentis is classified as isolated when it occurs alone without signs and symptoms affecting other body systems. (medlineplus.gov)
  • If you have good vision with spectacles and contact lenses, surgery for ectopia lentis can be denied. (icliniq.com)
  • I am a 25-year-female with ectopia lentis, and in recent months, I have felt pain and irritation in my eyes on wearing contact lenses. (icliniq.com)
  • Q. Why do my eyes get pain and swelling while wearing contact lenses in ectopia lentis? (icliniq.com)