Fatigue Syndrome, Chronic
Fatigue
Mental Fatigue
Muscle Fatigue
Xenotropic murine leukemia virus-related virus
Fibromyalgia
Kansas
Persian Gulf Syndrome
Gammaretrovirus
Cognitive Therapy
Down Syndrome
Metabolic Syndrome X
Neurocirculatory Asthenia
Case-Control Studies
Q Fever
Multiple Chemical Sensitivity
Severity of Illness Index
Sick Role
Postural Orthostatic Tachycardia Syndrome
Treatment Outcome
Questionnaires
Depression
Sjogren's Syndrome
Pain
Coxiella burnetii
Nephrotic Syndrome
Central Nervous System Sensitization
Infectious Mononucleosis
Dyssomnias
Somatoform Disorders
Exercise Therapy
Exercise
Herpesvirus 7, Human
Environmental Illness
Prevalence
Sleep Disorders
Metanephrine
Leukemia Virus, Murine
Chronic Disease
Human herpesviruses in chronic fatigue syndrome. (1/626)
We have conducted a double-blind study to assess the possible involvement of the human herpesviruses (HHVs) HHV6, HHV7, Epstein-Barr virus (EBV), and cytomegalovirus in chronic fatigue syndrome (CFS) patients compared to age-, race-, and gender-matched controls. The CFS patient population was composed of rigorously screened civilian and Persian Gulf War veterans meeting the Centers for Disease Control and Prevention's CFS case definition criteria. Healthy control civilian and veteran populations had no evidence of CFS or any other exclusionary medical or psychiatric condition. Patient peripheral blood mononuclear cells were analyzed by PCR for the presence of these HHVs. Using two-tailed Fisher's exact test analyses, we were unable to ascertain any statistically significant differences between the CFS patient and control populations in terms of the detection of one or more of these viruses. This observation was upheld when the CFS populations were further stratified with regard to the presence or absence of major axis I psychopathology and patient self-reported gradual versus acute onset of disease. In tandem, we performed serological analyses of serum anti-EBV and anti-HHV6 antibody titers and found no significant differences between the CFS and control patients. (+info)Use of formal and informal care among people with prolonged fatigue: a review of the literature. (2/626)
Prolonged fatigue is a common symptom in the community and a common complaint in GPs' surgeries. The current consensus is that prolonged fatigue is most appropriately managed within primary care but that quality of care is patchy. Diagnosis is difficult and there is no conclusive evidence about effective treatment. This can lead to confusion and controversy among lay people and health professionals alike. Although the value of a positive doctor-patient relationship is emphasized, general practice consultations are frequently experienced as difficult by both parties. Moreover, little is known about how people access other sources of care and information about prolonged fatigue, such as alternative medicine, self-help groups, lay others, and self care, in conjunction with or as an alternative to care from health professionals. This paper reviews the literature on the nature and extent of the problem prolonged fatigue represents for primary care, and on the use of formal and informal care for prolonged fatigue. (+info)Increased postwar symptoms and psychological morbidity among U.S. Navy Gulf War veterans. (3/626)
To investigate reports on war-related morbidity, 527 active-duty Gulf War veterans and 970 nondeployed veterans from 14 Seabee commands were studied in 1994 with a questionnaire, sera collection, handgrip strength, and pulmonary function testing. The questionnaire assessed postwar symptoms, war exposures, and screened for chronic fatigue syndrome, post-traumatic stress disorder, and psychological symptoms suggesting neurosis (Hopkins Symptom Checklist). Sera were tested with four nonspecific reactant assays: C-reactive protein, transferrin, ferritin, and haptoglobin. Gulf War veterans reported a higher prevalence for 35 of 41 symptoms, scored higher on psychological symptom scales, were more likely to screen for post-traumatic stress disorder, had lower handgrip strength, and had higher serum ferritin assay results. Numerous comparisons of these morbidity outcomes with 30 self-reported exposures demonstrated many associations, but no unique exposure or group of exposures were implicated. Morbidity data are consistent with other postwar observations, but the etiology for morbidity findings remains uncertain. (+info)DISCERN: an instrument for judging the quality of written consumer health information on treatment choices. (4/626)
OBJECTIVE: To develop a short instrument, called DISCERN, which will enable patients and information providers to judge the quality of written information about treatment choices. DISCERN will also facilitate the production of new, high quality, evidence-based consumer health information. DESIGN: An expert panel, representing a range of expertise in consumer health information, generated criteria from a random sample of information for three medical conditions with varying degrees of evidence: myocardial infarction, endometriosis, and chronic fatigue syndrome. A graft instrument, based on this analysis, was tested by the panel on a random sample of new material for the same three conditions. The panel re-drafted the instrument to take account of the results of the test. The DISCERN instrument was finally tested by a national sample of 15 information providers and 13 self help group members on a random sample of leaflets from 19 major national self help organisations. Participants also completed an 8 item questionnaire concerning the face and content validity of the instrument. RESULTS: Chance corrected agreement (weighted kappa) for the overall quality rating was kappa = 0.53 (95% CI kappa = 0.48 to kappa = 0.59) among the expert panel, kappa = 0.40 (95% CI kappa = 0.36 to kappa = 0.43) among information providers, and kappa = 0.23 (95% CI kappa = 0.19 to kappa = 0.27) among self help group members. Higher agreement levels were associated with experience of using the instrument and with professional knowledge of consumer health information. Levels of agreement varied across individual items on the instrument, reflecting the need for subjectivity in rating certain criteria. The trends in levels of agreement were similar among all groups. The final instrument consisted of 15 questions plus an overall quality rating. Responses to the questionnaire after the final testing revealed the instrument to have good face and content validity and to be generally applicable. CONCLUSIONS: DISCERN is a reliable and valid instrument for judging the quality of written consumer health information. While some subjectivity is required for rating certain criteria, the findings demonstrate that the instrument can be applied by experienced users and providers of health information to discriminate between publications of high and low quality. The instrument will also be of benefit to patients, though its use will be improved by training. (+info)Acute effects of thirty minutes of light-intensity, intermittent exercise on patients with chronic fatigue syndrome. (5/626)
BACKGROUND AND PURPOSE: Currently, there is no consensus on exercise prescription for patients with chronic fatigue syndrome (CFS). This investigation examined whether light-intensity, intermittent physical activity exacerbated symptoms in patients with CFS immediately following exercise to 7 days following exercise. Subjects. Subjects were 9 women (mean age=44.2 years, SD=8.4, range=29-56; mean weight=74.2 kg, SD=18.8, range=56.36-110.91; and mean height=1.63 m, SD=0.8, range=1.55-1.78) and 1 man (age=48 years, weight=97.1 kg, and height= 1.98 m) who met the Centels for Disease Control and Prevention's criteria fi)r (FS. METHODS: Subjects performed 10 discontinuous 3-minute exercise bouts (separated by 3 minutes of recovery) at a self-selected, comfortable walking pace on a treadmill. Oxygen consumption, minute ventilation, respiratory exchange ratio, and heart rate were measured every minute during the exercise session. To assess degree of disability, general health status, activity level, symptoms, and mood, subjects completed various questionnaires before and after exercise. RESULTS: Results indicated that degree of disability, general health status, symptoms, and mood did not change immediately and up to 7 days following exercise. CONCLUSION AND DISCUSSION: Thirty minutes of intermittent walking did not exacerbate symptoms in subjects with CFS. The physiological data did not show any abnormal response to exercise. Although this study did not determine whether 30 minutes of continuous versus intermittent exercise would exacerbate symptoms, all 10 subjects felt that they could not exercise continuously for 30 minutes without experiencing symptom exacerbation. Despite this limitation, the results indicate that some individuals with CFS may be able to use low-level, intermittent exercise without exacerbating their symptoms. (+info)Vitamin B status in patients with chronic fatigue syndrome. (6/626)
Some patients with chronic fatigue syndrome say they benefit from taking vitamin supplements. We assessed functional status for the B vitamins pyridoxine, riboflavin and thiamine in 12 vitamin-untreated CFS patients and in 18 healthy controls matched for age and sex. Vitamin-dependent activities--aspartate aminotransferase (AST) for pyridoxine, glutathione reductase (GTR) for riboflavin, transketolase (TK) for thiamine--were measured in erythrocyte haemolysates before and after in-vitro addition of the relevant vitamin. For all three enzymes basal activity (U/g Hb) was lower in CFS patients than in controls: AST 2.84 (SD 0.62) vs 4.61 (1.43), P < 0.001; GTR 6.13 (1.89) vs 7.42 (1.25), P < 0.04; TK 0.50 (0.13) vs 0.60 (0.07), P < 0.04. This was also true of activated values: AST 4.91 (0.54) vs 7.89 (2.11), P < 0.001; GTR 8.29 (1.60) vs 10.0 (1.80), P < 0.001; TK 0.56 (0.19) vs 0.66 (0.08), P < 0.07. The activation ratios, however, did not differ between the groups. These data provide preliminary evidence of reduced functional B vitamin status, particularly of pyridoxine, in CFS patients. (+info)Achieving a patient-centred consultation by giving feedback in its early phases. (7/626)
The traditional medical consultation comprises history, examination, and investigations, followed by explanation to the patient of diagnosis and management. In the course of studying a series of tape-recorded consultations in a specialist medical clinic for chronic fatigue, we have observed a different structure. In some consultations, those categorized as more 'patient-centred', doctors introduced explanation and education into the early history-taking stage. This strategy is contrasted with the traditional approach, where the doctor only elicits information during the history, and gives an explanation later. The 'early feedback' strategy may result in patients with chronic illnesses achieving greater understanding of their symptoms. We discuss the implication of these findings for medical training. (+info)Prediction of peak oxygen uptake in chronic fatigue syndrome. (8/626)
OBJECTIVES: To establish a simple, valid, and acceptable method of predicting peak oxygen uptake (VO2peak) in patients with chronic fatigue syndrome (CFS), which could provide a basis for subsequent exercise prescription at an appropriate intensity as part of a clinical rehabilitation programme. METHODS: A total of 130 patients who met UK research criteria for CFS were taken from consecutive referrals for chronic fatigue to the University Department of Medicine at Withington Hospital, Manchester. VO2peak was determined using an incremental graded exercise test to exhaustion. Respiratory gas exchange, work rate, and heart rate were monitored throughout. RESULTS: In all patients, VO2peak was found to correlate strongly and significantly with peak work rate (WRpeak) during testing (r2 = 0.88, p<0.001). In patients who exercised for longer than two minutes (n = 119), regression analysis established the relation as Vo2peak = 13.1 x WRPpeak + 284, where VO2 is given in ml/min and WR in W. The mean error between the measured VO2peak and the predicted value was 10.7%. The relation between increase in work rate and oxygen uptake across the group was highly significant (r2 = 0.87, p<0.001), and given as VO2increase = 12.0 x WRincrease, this value being similar to that expected for healthy individuals. Almost all (97%) subjects reported no exacerbation of symptoms after maximal exercise testing. CONCLUSIONS: Using a simple to administer maximal exercise test on a cycle ergometer, it is possible to predict accurately the VO2peak of a patient with CFS from peak work rate alone. This value can then be used as an aid to setting appropriate exercise intensity for a rehabilitation programme. The increase in VO2 per unit increase in workload was consistent with that expected in healthy individuals, suggesting that the physiological response of the patients measured here was not abnormal. Contrary to the belief of many patients, maximal exercise testing to the point of subjective exhaustion proved to be harmless, with no subjects suffering any lasting deterioration in their condition after assessment. (+info)Chronic Fatigue Syndrome (CFS) is a complex disorder characterized by extreme fatigue that does not improve with rest and is often worsened by physical or mental activity. The exact cause of CFS remains unknown, although it can be triggered by various factors such as infections, immune system dysfunction, hormonal imbalances, and stress.
The main symptom of CFS is severe fatigue that lasts for six months or longer, which is not relieved by rest and is often accompanied by other symptoms such as:
* Difficulty concentrating or remembering things
* Sore throat
* Swollen lymph nodes in the neck or armpits
* Muscle pain
* Joint pain without redness or swelling
* Headaches of a new type, pattern, or severity
* Unrefreshing sleep
* Extreme exhaustion lasting more than 24 hours after physical or mental exercise
The diagnosis of CFS is based on the patient's symptoms and medical history, as there are no specific diagnostic tests for this condition. Treatment typically focuses on relieving symptoms and improving function through a combination of medications, lifestyle changes, and complementary therapies.
Fatigue is a state of feeling very tired, weary, or exhausted, which can be physical, mental, or both. It is a common symptom that can be caused by various factors, including lack of sleep, poor nutrition, stress, medical conditions (such as anemia, diabetes, heart disease, or cancer), medications, and substance abuse. Fatigue can also be a symptom of depression or other mental health disorders. In medical terms, fatigue is often described as a subjective feeling of tiredness that is not proportional to recent activity levels and interferes with usual functioning. It is important to consult a healthcare professional if experiencing persistent or severe fatigue to determine the underlying cause and develop an appropriate treatment plan.
A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.
For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.
It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.
Mental fatigue is not a formally defined medical condition, but it's often used to describe the feeling of being mentally drained or exhausted due to prolonged periods of mental activity or stress. It can be characterized by symptoms such as difficulty concentrating, memory problems, mood changes, and reduced motivation or energy.
While mental fatigue is not a diagnosable medical condition, it can be a symptom of various underlying issues, including sleep disorders, mood disorders, neurological conditions, or other medical problems. If someone is experiencing significant mental fatigue that interferes with their daily functioning, they should consult a healthcare professional for further evaluation and treatment.
Muscle fatigue is a condition characterized by a reduction in the ability of a muscle to generate force or power, typically after prolonged or strenuous exercise. It is often accompanied by sensations of tiredness, weakness, and discomfort in the affected muscle(s). The underlying mechanisms of muscle fatigue are complex and involve both peripheral factors (such as changes in muscle metabolism, ion handling, and neuromuscular transmission) and central factors (such as changes in the nervous system's ability to activate muscles). Muscle fatigue can also occur as a result of various medical conditions or medications that impair muscle function.
Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus that was first identified in prostate cancer tissue samples in 2006. The name "xenotropic" refers to the fact that this virus can only infect cells from other species, not those of its natural host, which is thought to be a mouse. "Murine leukemia virus-related" indicates that XMRV is related to, but distinct from, murine leukemia viruses (MLVs), which are known to cause leukemia and other diseases in mice.
XMRV has been the subject of much controversy and research since its discovery, as some studies have suggested a link between this virus and human diseases such as prostate cancer and chronic fatigue syndrome. However, subsequent research has failed to consistently detect XMRV in these conditions, leading many experts to question whether the virus actually plays a role in human disease.
It's important to note that while XMRV is a retrovirus, like HIV, it is not considered to be a significant public health threat at this time. Further research is needed to clarify the relationship between XMRV and human disease.
Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties. The pain typically occurs in specific tender points or trigger points, which are located on the neck, shoulders, back, hips, arms, and legs. These points are painful when pressure is applied.
The exact cause of fibromyalgia is unknown, but it appears to be related to abnormalities in the way the brain processes pain signals. It may also be associated with certain genetic factors, physical trauma, infection, or emotional stress. Fibromyalgia is more common in women than men and tends to develop between the ages of 20 and 50.
Fibromyalgia can be difficult to diagnose because its symptoms are similar to those of other conditions, such as rheumatoid arthritis, lupus, and chronic fatigue syndrome. However, a diagnosis of fibromyalgia may be made if a person has widespread pain for at least three months and tenderness in at least 11 of 18 specific points on the body when pressure is applied.
There is no cure for fibromyalgia, but medications, therapy, and lifestyle changes can help manage its symptoms. Treatment may include pain relievers, antidepressants, anti-seizure drugs, physical therapy, counseling, stress reduction techniques, and regular exercise.
I'm sorry for any confusion, but "Kansas" is not a medical term. It is a geographical location, being the name of a state in the central United States. If you have any questions about medical terms or conditions, I would be happy to help answer those!
Retroviridae infections refer to diseases caused by retroviruses, which are a type of virus that integrates its genetic material into the DNA of the host cell. This allows the virus to co-opt the cell's own machinery to produce new viral particles and infect other cells.
Some well-known retroviruses include human immunodeficiency virus (HIV), which causes AIDS, and human T-lymphotropic virus (HTLV), which can cause certain types of cancer and neurological disorders.
Retroviral infections can have a range of clinical manifestations depending on the specific virus and the host's immune response. HIV infection, for example, is characterized by progressive immunodeficiency that makes the infected individual susceptible to a wide range of opportunistic infections and cancers. HTLV infection, on the other hand, can cause adult T-cell leukemia/lymphoma or tropical spastic paraparesis, a neurological disorder.
Prevention and treatment strategies for retroviral infections depend on the specific virus but may include antiretroviral therapy (ART), vaccination, and behavioral modifications to reduce transmission risk.
I'm sorry for any confusion, but "Persian Gulf Syndrome" is not a widely recognized or officially defined medical condition. The term has been used informally to describe various nonspecific symptoms such as fatigue, cognitive problems, and muscle pain reported by some military personnel who served in the Persian Gulf region. However, these symptoms are common and can be caused by many different factors, so it's not clear that they are related to service in the Persian Gulf.
The Department of Veterans Affairs (VA) recognizes "Persian Gulf War Veterans' Illnesses" as a category of unexplained illnesses that some veterans of the 1990-1991 Gulf War experience. This includes conditions such as chronic fatigue syndrome, fibromyalgia, and functional gastrointestinal disorders, among others. But it's important to note that these are recognized diseases with specific diagnostic criteria, not a single syndrome.
If you or someone else is experiencing persistent health issues that may be related to military service, it's recommended to consult with a healthcare provider. They can provide a thorough evaluation and help determine if the symptoms are related to service or some other cause.
DNA contamination refers to the unintended presence of extraneous DNA in a sample or experimental setup that can interfere with the accuracy and interpretation of the results. This can occur at various stages, including during sample collection, storage, extraction, amplification, or analysis. It is crucial to avoid DNA contamination in molecular biology research, genetic testing, and forensic science to prevent false positive or negative results. Common sources of DNA contamination include skin cells, hair, bodily fluids, microorganisms, reagents, and previous samples. Specific measures must be taken to minimize the risk of DNA contamination, such as using dedicated equipment, maintaining clean laboratory conditions, and implementing rigorous quality control procedures.
A gammaretrovirus is a type of retrovirus, which is a virus that contains RNA as its genetic material and uses the reverse transcriptase enzyme to produce DNA from its RNA genome. Gammaretroviruses are enveloped viruses, meaning they have a lipid membrane derived from the host cell. They are also classified as simple retroviruses because their genome only contains the genes gag, pol, and env.
Gammaretroviruses are known to cause diseases in animals, including leukemias and immunodeficiencies. One example of a gammaretrovirus is the feline leukemia virus (FeLV), which can cause a variety of symptoms in cats, including anemia, lymphoma, and immune suppression.
Gammaretroviruses have also been implicated in some human diseases, although they are not thought to be major causes of human disease. For example, the human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that is closely related to gammaretroviruses and can cause adult T-cell leukemia/lymphoma and tropical spastic paraparesis/ HTLV-associated myelopathy (TSP/HAM).
It's important to note that the classification of retroviruses has evolved over time, and some viruses that were once classified as gammaretroviruses are now considered to be part of other retrovirus genera.
Cognitive Therapy (CT) is a type of psychotherapeutic treatment that helps patients understand the thoughts and feelings that influence behaviors. It is a form of talk therapy where the therapist and the patient work together to identify and change negative or distorted thinking patterns and beliefs, with the goal of improving emotional response and behavior.
Cognitive Therapy is based on the idea that our thoughts, feelings, and behaviors are all interconnected, and that negative or inaccurate thoughts can contribute to problems like anxiety and depression. By identifying and challenging these thoughts, patients can learn to think more realistically and positively, which can lead to improvements in their mood and behavior.
In cognitive therapy sessions, the therapist will help the patient identify negative thought patterns and replace them with healthier, more accurate ways of thinking. The therapist may also assign homework or exercises for the patient to practice between sessions, such as keeping a thought record or challenging negative thoughts.
Cognitive Therapy has been shown to be effective in treating a wide range of mental health conditions, including depression, anxiety disorders, eating disorders, and post-traumatic stress disorder (PTSD). It is often used in combination with other forms of treatment, such as medication, and can be delivered individually or in group settings.
Down syndrome is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is characterized by intellectual and developmental disabilities, distinctive facial features, and sometimes physical growth delays and health problems. The condition affects approximately one in every 700 babies born in the United States.
Individuals with Down syndrome have varying degrees of cognitive impairment, ranging from mild to moderate or severe. They may also have delayed development, including late walking and talking, and may require additional support and education services throughout their lives.
People with Down syndrome are at increased risk for certain health conditions, such as congenital heart defects, respiratory infections, hearing loss, vision problems, gastrointestinal issues, and thyroid disorders. However, many individuals with Down syndrome live healthy and fulfilling lives with appropriate medical care and support.
The condition is named after John Langdon Down, an English physician who first described the syndrome in 1866.
Metabolic syndrome, also known as Syndrome X, is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes. It is not a single disease but a group of risk factors that often co-occur. According to the American Heart Association and the National Heart, Lung, and Blood Institute, a person has metabolic syndrome if they have any three of the following five conditions:
1. Abdominal obesity (waist circumference of 40 inches or more in men, and 35 inches or more in women)
2. Triglyceride level of 150 milligrams per deciliter of blood (mg/dL) or greater
3. HDL cholesterol level of less than 40 mg/dL in men or less than 50 mg/dL in women
4. Systolic blood pressure of 130 millimeters of mercury (mmHg) or greater, or diastolic blood pressure of 85 mmHg or greater
5. Fasting glucose level of 100 mg/dL or greater
Metabolic syndrome is thought to be caused by a combination of genetic and lifestyle factors, such as physical inactivity and a diet high in refined carbohydrates and unhealthy fats. Treatment typically involves making lifestyle changes, such as eating a healthy diet, getting regular exercise, and losing weight if necessary. In some cases, medication may also be needed to manage individual components of the syndrome, such as high blood pressure or high cholesterol.
Neurocirculatory asthenia is not a term that is widely used in modern medicine. However, historically, it has been used as a descriptive diagnosis for a group of symptoms characterized by fatigue, weakness, dizziness, and disturbances of heart rate and blood pressure, often in response to emotional stress or physical exertion.
The term "neurocirculatory" refers to the interaction between the nervous system and the cardiovascular system, while "asthenia" is a general term used to describe a lack of energy or weakness.
In modern medicine, this condition may be diagnosed as a form of functional disorder, neurasthenia, or somatic symptom disorder, depending on the specific symptoms and underlying causes. It's important to note that while these symptoms can be real and debilitating, they do not have a clear organic cause, and treatment typically focuses on managing symptoms and addressing any underlying psychological or emotional factors.
A case-control study is an observational research design used to identify risk factors or causes of a disease or health outcome. In this type of study, individuals with the disease or condition (cases) are compared with similar individuals who do not have the disease or condition (controls). The exposure history or other characteristics of interest are then compared between the two groups to determine if there is an association between the exposure and the disease.
Case-control studies are often used when it is not feasible or ethical to conduct a randomized controlled trial, as they can provide valuable insights into potential causes of diseases or health outcomes in a relatively short period of time and at a lower cost than other study designs. However, because case-control studies rely on retrospective data collection, they are subject to biases such as recall bias and selection bias, which can affect the validity of the results. Therefore, it is important to carefully design and conduct case-control studies to minimize these potential sources of bias.
Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. It is characterized by acute or chronic flu-like symptoms, pneumonia, and hepatitis. The bacteria are primarily transmitted to humans through inhalation of contaminated dust or aerosols from infected animals such as cattle, sheep, and goats. Q fever can also be transmitted through consumption of unpasteurized milk or direct contact with infected animals. It is often asymptomatic or mildly symptomatic in animals but can cause severe disease in humans.
The acute form of Q fever typically presents with sudden onset of high fever, severe headache, fatigue, muscle pain, and cough. Some patients may also develop pneumonia or hepatitis. The chronic form of the disease is less common but more serious, often affecting people with compromised immune systems. Chronic Q fever can lead to endocarditis, an infection of the inner lining of the heart, which can be life-threatening if left untreated.
Diagnosis of Q fever typically involves a combination of clinical evaluation, serological testing, and PCR (polymerase chain reaction) assays. Treatment usually involves antibiotics such as doxycycline or fluoroquinolones for several weeks to months, depending on the severity and duration of the illness. Prevention measures include avoiding contact with infected animals, wearing protective clothing and masks when handling animal products, and pasteurizing milk before consumption.
Multiple Chemical Sensitivity (MCS), also known as Idiosyncratic Intolerance, is a chronic condition characterized by symptoms that the affected person attributes to low-level exposure to chemicals in the environment. These reactions are not part of a recognized allergic response and are often delayed in onset.
The American Academy of Allergy, Asthma & Immunology (AAAAI) defines MCS as: "A heightened sensitivity to chemicals that most people tolerate well... Symptoms can include headache, fatigue, difficulty concentrating, confusion, joint pain, and digestive disturbances."
However, it's important to note that the medical community has not reached a consensus on the definition, cause, or diagnosis of MCS. Some healthcare providers question its validity as a distinct medical entity due to lack of consistent scientific evidence supporting the relationship between exposure levels and symptoms.
A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.
Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.
It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.
The "Sick Role" is a sociological concept that refers to the social position and expectations associated with being ill or sick. It was first introduced by sociologist Talcott Parsons in his 1951 work, "The Social System." According to Parsons, when an individual assumes the sick role, they are exempt from their normal social responsibilities and obligations. However, they are also expected to seek medical help, comply with medical treatment recommendations, and strive to get better and return to their regular social roles as soon as possible.
The sick role involves several key components:
1. The individual is not responsible for their illness and did not cause it intentionally.
2. They are exempt from normal social obligations and responsibilities, such as work or household duties.
3. They must seek medical help and follow the recommended treatment plan.
4. They should strive to get better and return to their regular social roles as soon as possible.
The sick role serves several functions in society, including:
1. Providing a framework for understanding and responding to illness.
2. Encouraging individuals to seek medical help when they are ill.
3. Allowing individuals to take a break from their normal social obligations while they recover.
4. Helping to maintain social order by ensuring that individuals do not abuse the sick role and return to their regular roles as soon as possible.
Postural Orthostatic Tachycardia Syndrome (POTS) is a condition characterized by an abnormally rapid heart rate (tachycardia) that occurs upon standing, leading to symptoms such as dizziness, lightheadedness, and fainting. The diagnostic criteria for POTS include:
1. A heart rate increase of 30 beats per minute or more within the first 10 minutes of standing or a heart rate of 120 beats per minute or more within the first 10 minutes of standing, measured by a heart rate monitor.
2. The presence of symptoms such as lightheadedness, dizziness, blurred vision, weakness, fatigue, headache, shortness of breath, or chest pain upon standing that are relieved by lying down.
3. Symptoms must be present for at least three months and occur in the absence of other medical conditions that could explain them.
POTS is thought to be caused by a dysfunction of the autonomic nervous system, which controls involuntary functions such as heart rate and blood pressure. Treatment may include lifestyle modifications, such as increasing fluid and salt intake, wearing compression stockings, and avoiding prolonged standing or sitting. Medications that help regulate blood pressure and heart rate may also be prescribed.
Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.
A questionnaire in the medical context is a standardized, systematic, and structured tool used to gather information from individuals regarding their symptoms, medical history, lifestyle, or other health-related factors. It typically consists of a series of written questions that can be either self-administered or administered by an interviewer. Questionnaires are widely used in various areas of healthcare, including clinical research, epidemiological studies, patient care, and health services evaluation to collect data that can inform diagnosis, treatment planning, and population health management. They provide a consistent and organized method for obtaining information from large groups or individual patients, helping to ensure accurate and comprehensive data collection while minimizing bias and variability in the information gathered.
Depression is a mood disorder that is characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities. It can also cause significant changes in sleep, appetite, energy level, concentration, and behavior. Depression can interfere with daily life and normal functioning, and it can increase the risk of suicide and other mental health disorders. The exact cause of depression is not known, but it is believed to be related to a combination of genetic, biological, environmental, and psychological factors. There are several types of depression, including major depressive disorder, persistent depressive disorder, postpartum depression, and seasonal affective disorder. Treatment for depression typically involves a combination of medication and psychotherapy.
Sjögren's syndrome is a chronic autoimmune disorder in which the body's immune system mistakenly attacks its own moisture-producing glands, particularly the tear and salivary glands. This can lead to symptoms such as dry eyes, dry mouth, and dryness in other areas of the body. In some cases, it may also affect other organs, leading to a variety of complications.
There are two types of Sjögren's syndrome: primary and secondary. Primary Sjögren's syndrome occurs when the condition develops on its own, while secondary Sjögren's syndrome occurs when it develops in conjunction with another autoimmune disease, such as rheumatoid arthritis or lupus.
The exact cause of Sjögren's syndrome is not fully understood, but it is believed to involve a combination of genetic and environmental factors. Treatment typically focuses on relieving symptoms and may include artificial tears, saliva substitutes, medications to stimulate saliva production, and immunosuppressive drugs in more severe cases.
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It is a complex phenomenon that can result from various stimuli, such as thermal, mechanical, or chemical irritation, and it can be acute or chronic. The perception of pain involves the activation of specialized nerve cells called nociceptors, which transmit signals to the brain via the spinal cord. These signals are then processed in different regions of the brain, leading to the conscious experience of pain. It's important to note that pain is a highly individual and subjective experience, and its perception can vary widely among individuals.
Coxiella burnetii is a gram-negative, intracellular bacterium that causes Q fever, a zoonotic disease with various clinical manifestations ranging from asymptomatic seroconversion to acute and chronic forms. The bacterium is highly infectious and can be transmitted to humans through inhalation of contaminated aerosols or direct contact with infected animals or their products. C. burnetii has a unique ability to survive and replicate within host cells, particularly within phagocytic vacuoles, by inhibiting phagosome-lysosome fusion and altering the intracellular environment to promote its survival.
The bacterium exhibits a biphasic developmental cycle, consisting of small cell variants (SCVs) and large cell variants (LCVs). SCVs are metabolically inactive and highly resistant to environmental stressors, including heat, desiccation, and disinfectants. LCVs, on the other hand, are metabolically active and undergo replication within host cells. C. burnetii can form persistent infections, which may contribute to chronic Q fever and its associated complications, such as endocarditis and vascular infection.
Q fever is a worldwide distributed disease, with a higher incidence in rural areas where livestock farming is prevalent. The primary reservoirs for C. burnetii are domestic animals, including cattle, sheep, and goats, although wild animals and arthropods can also serve as potential hosts. Effective antibiotic treatment options for Q fever include doxycycline and fluoroquinolones, while vaccination with the phase I whole-cell vaccine is available in some countries to prevent infection in high-risk populations.
Nephrotic syndrome is a group of symptoms that indicate kidney damage, specifically damage to the glomeruli—the tiny blood vessel clusters in the kidneys that filter waste and excess fluids from the blood. The main features of nephrotic syndrome are:
1. Proteinuria (excess protein in urine): Large amounts of a protein called albumin leak into the urine due to damaged glomeruli, which can't properly filter proteins. This leads to low levels of albumin in the blood, causing fluid buildup and swelling.
2. Hypoalbuminemia (low blood albumin levels): As albumin leaks into the urine, the concentration of albumin in the blood decreases, leading to hypoalbuminemia. This can cause edema (swelling), particularly in the legs, ankles, and feet.
3. Edema (fluid retention and swelling): With low levels of albumin in the blood, fluids move into the surrounding tissues, causing swelling or puffiness. The swelling is most noticeable around the eyes, face, hands, feet, and abdomen.
4. Hyperlipidemia (high lipid/cholesterol levels): The kidneys play a role in regulating lipid metabolism. Damage to the glomeruli can lead to increased lipid production and high cholesterol levels in the blood.
Nephrotic syndrome can result from various underlying kidney diseases, such as minimal change disease, membranous nephropathy, or focal segmental glomerulosclerosis. Treatment depends on the underlying cause and may include medications to control inflammation, manage high blood pressure, and reduce proteinuria. In some cases, dietary modifications and lifestyle changes are also recommended.
Central nervous system (CNS) sensitization refers to a state in which the CNS, specifically the brain and spinal cord, becomes increasingly hypersensitive to stimuli. This heightened sensitivity results in an amplified response to painful or non-painful stimuli.
In CNS sensitization, there is an increased responsiveness of neurons in the CNS, leading to a lower threshold for activation and an enhanced transmission of nociceptive (pain) signals. This can occur due to various factors such as tissue injury, inflammation, or nerve damage, which trigger changes in the nervous system that contribute to the development and maintenance of chronic pain conditions.
CNS sensitization is associated with functional and structural reorganization within the CNS, including alterations in neurotransmitter release, ion channel function, and synaptic plasticity. These changes can result in long-term modifications in the processing and perception of pain, making it more difficult to manage and treat chronic pain conditions.
Infectious Mononucleosis, also known as "mono" or the "kissing disease," is a common infectious illness caused by the Epstein-Barr virus (EBV). It primarily affects adolescents and young adults. The medical definition of Infectious Mononucleosis includes the following signs and symptoms:
1. Infection: Infectious Mononucleosis is an infection that spreads through saliva, hence the nickname "kissing disease." It can also be transmitted through sharing food, drinks, or personal items such as toothbrushes or utensils with an infected person.
2. Incubation period: The incubation period for Infectious Mononucleosis is typically 4-6 weeks after exposure to the virus.
3. Symptoms: Common symptoms of Infectious Mononucleosis include fever, sore throat (often severe and may resemble strep throat), fatigue, swollen lymph nodes (particularly in the neck and armpits), and skin rash (in some cases).
4. Diagnosis: The diagnosis of Infectious Mononucleosis is typically made based on a combination of clinical symptoms, physical examination findings, and laboratory test results. A complete blood count (CBC) may reveal an increased number of white blood cells, particularly atypical lymphocytes. Additionally, the Paul-Bunnell or Monospot test can detect heterophile antibodies, which are present in about 85% of cases after the first week of illness.
5. Treatment: There is no specific antiviral treatment for Infectious Mononucleosis. Management typically involves supportive care, such as rest, hydration, and pain relief for symptoms like sore throat and fever.
6. Complications: Although most cases of Infectious Mononucleosis resolve without significant complications, some individuals may experience complications such as splenomegaly (enlarged spleen), hepatitis, or neurological issues. Rarely, the virus can cause more severe complications like myocarditis (inflammation of the heart muscle) or hemolytic anemia (destruction of red blood cells).
7. Prevention: Preventing Infectious Mononucleosis is difficult since it is primarily spread through respiratory droplets and saliva. However, practicing good hygiene, such as covering the mouth and nose when coughing or sneezing and avoiding sharing personal items like utensils or drinking glasses, can help reduce the risk of transmission.
Dyssomnias are a category of sleep disorders that involve problems with the amount, quality, or timing of sleep. They can be broken down into several subcategories, including:
1. Insomnia: This is characterized by difficulty falling asleep or staying asleep, despite adequate opportunity and circumstances to do so. It can result in distress, impairment in social, occupational, or other areas of functioning, and/or feelings of dissatisfaction with sleep.
2. Hypersomnias: These are disorders that involve excessive sleepiness during the day, even after having adequate opportunity for sleep. Narcolepsy is an example of a hypersomnia.
3. Sleep-related breathing disorders: These include conditions such as obstructive sleep apnea, in which breathing is repeatedly interrupted during sleep, leading to poor sleep quality and excessive daytime sleepiness.
4. Circadian rhythm sleep-wake disorders: These involve disruptions to the body's internal clock, which can result in difficulty falling asleep or staying asleep at desired times. Jet lag and shift work disorder are examples of circadian rhythm sleep-wake disorders.
5. Parasomnias: These are disruptive sleep-related events that occur during various stages of sleep, such as sleepwalking, night terrors, and REM sleep behavior disorder.
Dyssomnias can have significant impacts on a person's quality of life, and it is important to seek medical evaluation if you are experiencing symptoms. Treatment may involve lifestyle changes, medication, or other interventions depending on the specific type of dyssomnia.
Somatoform disorders are a group of psychological disorders characterized by the presence of physical symptoms that cannot be fully explained by a medical condition or substance abuse. These symptoms cause significant distress and impairment in social, occupational, or other important areas of functioning. The individual's belief about the symptoms is not consistent with the medical evaluation and often leads to excessive or repeated medical evaluations.
Examples of somatoform disorders include:
1. Somatization disorder: characterized by multiple physical symptoms that cannot be explained medically, affecting several parts of the body.
2. Conversion disorder: characterized by the presence of one or more neurological symptoms (such as blindness, paralysis, or difficulty swallowing) that cannot be explained medically and appear to have a psychological origin.
3. Pain disorder: characterized by chronic pain that is not fully explained by a medical condition.
4. Hypochondriasis: characterized by an excessive preoccupation with having a serious illness, despite reassurance from medical professionals.
5. Body dysmorphic disorder: characterized by the obsessive idea that some aspect of one's own body part or appearance is severely flawed and warrants exceptional measures to hide or fix it.
It's important to note that these disorders are not caused by intentional deceit or malingering, but rather reflect a genuine belief in the presence of physical symptoms and distress related to them.
Exercise therapy is a type of medical treatment that uses physical movement and exercise to improve a patient's physical functioning, mobility, and overall health. It is often used as a component of rehabilitation programs for individuals who have experienced injuries, illnesses, or surgeries that have impaired their ability to move and function normally.
Exercise therapy may involve a range of activities, including stretching, strengthening, balance training, aerobic exercise, and functional training. The specific exercises used will depend on the individual's needs, goals, and medical condition.
The benefits of exercise therapy include:
* Improved strength and flexibility
* Increased endurance and stamina
* Enhanced balance and coordination
* Reduced pain and inflammation
* Improved cardiovascular health
* Increased range of motion and joint mobility
* Better overall physical functioning and quality of life.
Exercise therapy is typically prescribed and supervised by a healthcare professional, such as a physical therapist or exercise physiologist, who has experience working with individuals with similar medical conditions. The healthcare professional will create an individualized exercise program based on the patient's needs and goals, and will provide guidance and support to ensure that the exercises are performed safely and effectively.
Exercise is defined in the medical context as a physical activity that is planned, structured, and repetitive, with the primary aim of improving or maintaining one or more components of physical fitness. Components of physical fitness include cardiorespiratory endurance, muscular strength, muscular endurance, flexibility, and body composition. Exercise can be classified based on its intensity (light, moderate, or vigorous), duration (length of time), and frequency (number of times per week). Common types of exercise include aerobic exercises, such as walking, jogging, cycling, and swimming; resistance exercises, such as weightlifting; flexibility exercises, such as stretching; and balance exercises. Exercise has numerous health benefits, including reducing the risk of chronic diseases, improving mental health, and enhancing overall quality of life.
Human Herpesvirus 7 (HHV-7) is a species of the Herpesviridae family and Betaherpesvirinae subfamily. It is a double-stranded DNA virus that primarily infects human hosts. HHV-7 is closely related to Human Herpesvirus 6 (HHV-6) and both viruses share many biological and biochemical properties.
HHV-7 is typically acquired in early childhood, with most people becoming infected before the age of five. Primary infection with HHV-7 can cause a mild illness known as exanthema subitum or roseola infantum, which is characterized by fever and a rash. However, many HHV-7 infections are asymptomatic.
After initial infection, HHV-7 becomes latent in the host's immune cells, particularly CD4+ T-lymphocytes. The virus can reactivate later in life, causing various clinical manifestations such as chronic fatigue syndrome, seizures, and exacerbation of atopic dermatitis. HHV-7 has also been implicated in the development of certain malignancies, including lymphoproliferative disorders and some types of brain tumors.
Like other herpesviruses, HHV-7 establishes a lifelong infection in its human host, with periodic reactivation throughout the individual's lifetime.
Environmental Illness (EI) is a condition in which individuals report experiencing various symptoms that they believe are caused or worsened by exposure to specific environmental factors. These factors can include chemicals, allergens, pollutants, or other substances present in the air, water, or food. The symptoms of EI can vary widely and may include headaches, fatigue, difficulty concentrating, respiratory problems, skin irritations, and gastrointestinal issues.
It's important to note that while some people may be more sensitive than others to environmental factors, the term "Environmental Illness" is not recognized as a formal medical diagnosis by major medical organizations such as the American Medical Association or the World Health Organization. Instead, the symptoms of EI are often attributed to other conditions, such as allergies, asthma, or chemical sensitivities.
In some cases, individuals with EI may be diagnosed with a related condition called Multiple Chemical Sensitivity (MCS), which is characterized by heightened sensitivity to chemicals and other environmental factors. However, MCS is also not recognized as a formal medical diagnosis by many major medical organizations.
Overall, while some people may experience symptoms that they believe are caused by exposure to environmental factors, it's important to consult with a healthcare provider for an accurate diagnosis and treatment plan.
Prevalence, in medical terms, refers to the total number of people in a given population who have a particular disease or condition at a specific point in time, or over a specified period. It is typically expressed as a percentage or a ratio of the number of cases to the size of the population. Prevalence differs from incidence, which measures the number of new cases that develop during a certain period.
Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis. They can include problems with falling asleep, staying asleep, or waking up too early in the morning. These disorders can be caused by various factors such as stress, anxiety, depression, medical conditions, or substance abuse.
The American Academy of Sleep Medicine (AASM) recognizes over 80 distinct sleep disorders, which are categorized into the following major groups:
1. Insomnia - difficulty falling asleep or staying asleep.
2. Sleep-related breathing disorders - abnormal breathing during sleep such as obstructive sleep apnea.
3. Central disorders of hypersomnolence - excessive daytime sleepiness, including narcolepsy.
4. Circadian rhythm sleep-wake disorders - disruption of the internal body clock that regulates the sleep-wake cycle.
5. Parasomnias - abnormal behaviors during sleep such as sleepwalking or night terrors.
6. Sleep-related movement disorders - repetitive movements during sleep such as restless legs syndrome.
7. Isolated symptoms and normal variants - brief and occasional symptoms that do not warrant a specific diagnosis.
Sleep disorders can have significant impacts on an individual's quality of life, productivity, and overall health. If you suspect that you may have a sleep disorder, it is recommended to consult with a healthcare professional or a sleep specialist for proper evaluation and treatment.
Metanephrine is a catecholamine metabolite, specifically a derivative of epinephrine (adrenaline). It is formed in the body through the metabolic breakdown of epinephrine by the enzyme catechol-O-methyltransferase (COMT). Metanephrines, including metanephrine and normetanephrine, are primarily produced in the adrenal glands but can also be found in other tissues in smaller amounts.
Elevated levels of metanephrines in the blood or urine may indicate a pheochromocytoma, a rare tumor originating from the chromaffin cells of the adrenal medulla, or a paraganglioma, a similar type of tumor located outside the adrenal glands. These tumors can cause excessive production of catecholamines, including epinephrine and norepinephrine, leading to increased metanephrine levels.
It is essential to differentiate between metanephrine and normetanephrine as they have distinct clinical implications. Normetanephrine is a derivative of norepinephrine (noradrenaline), while metanephrine originates from epinephrine. The measurement of both free metanephrines and normetanephrines in plasma or urine is often used to diagnose and monitor pheochromocytomas and paragangliomas.
Medical Definition:
Murine leukemia virus (MLV) is a type of retrovirus that primarily infects and causes various types of malignancies such as leukemias and lymphomas in mice. It is a complex genus of viruses, with many strains showing different pathogenic properties.
MLV contains two identical single-stranded RNA genomes and has the ability to reverse transcribe its RNA into DNA upon infection, integrating this proviral DNA into the host cell's genome. This is facilitated by an enzyme called reverse transcriptase, which MLV carries within its viral particle.
The virus can be horizontally transmitted between mice through close contact with infected saliva, urine, or milk. Vertical transmission from mother to offspring can also occur either in-utero or through the ingestion of infected breast milk.
MLV has been extensively studied as a model system for retroviral pathogenesis and tumorigenesis, contributing significantly to our understanding of oncogenes and their role in cancer development. It's important to note that Murine Leukemia Virus does not infect humans.
A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.
'Diseases in Twins' is a field of study that focuses on the similarities and differences in the occurrence, development, and outcomes of diseases among twins. This research can provide valuable insights into the genetic and environmental factors that contribute to various medical conditions.
Twins can be classified into two types: monozygotic (identical) and dizygotic (fraternal). Monozygotic twins share 100% of their genes, while dizygotic twins share about 50%, similar to non-twin siblings. By comparing the concordance rates (the likelihood of both twins having the same disease) between monozygotic and dizygotic twins, researchers can estimate the heritability of a particular disease.
Studying diseases in twins also helps understand the role of environmental factors. When both twins develop the same disease, but they are discordant for certain risk factors (e.g., one twin smokes and the other does not), it suggests that the disease may have a stronger genetic component. On the other hand, when both twins share similar risk factors and develop the disease, it implies that environmental factors play a significant role.
Diseases in Twins research has contributed to our understanding of various medical conditions, including infectious diseases, cancer, mental health disorders, and developmental disorders. This knowledge can lead to better prevention strategies, early detection methods, and more targeted treatments for these diseases.
Chronic fatigue syndrome
Chronic fatigue syndrome treatment
Chronic Fatigue Syndrome Advisory Committee
History of chronic fatigue syndrome
Controversies related to chronic fatigue syndrome
Clinical descriptions of chronic fatigue syndrome
List of people with chronic fatigue syndrome
Photophobia
Thomas Budzynski
Charles Raison
William Paul Fife
Food intolerance
Osteomyelitis of the jaws
Sex differences in medicine
Bill Lichtenstein
David Satcher
The Infinite Mind
Fatigue
1988 in science
Leonard A. Jason
Henry Percy, 11th Duke of Northumberland
Adrenergic receptor autoantibodies
Donnica Moore
Keiji Fukuda
Rintatolimod
Sophia Mirza
Dysautonomia
Robyn van Nus
Human herpesvirus 6
Susan Blackmore
Central nervous system fatigue
Idiopathic chronic fatigue
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | CDC
Chronic Fatigue Syndrome | CFS | MedlinePlus
Chronic fatigue syndrome - Wikipedia
Chronic Fatigue Syndrome -- Advancing Research and Education
Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): Practice Essentials
Chronic Fatigue Syndrome
IOM Gives Chronic Fatigue Syndrome a New Name and Definition
CDC Grand Rounds: Chronic Fatigue Syndrome - Advancing Research and Clinical Education | MMWR
Optimizing Blood Sugar Control in Chronic Fatigue Syndrome | Psychology Today
Chronic Fatigue Syndrome, Fibromyalgia, and Other
Chronic fatigue syndrome - Wikipedia
Gulf war illness, chronic fatigue syndrome distinct illnesses, study suggests | ScienceDaily
Diagnosis | Information for Healthcare Providers | Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS | CDC
9.5M center grant for chronic fatigue syndrome research
2015 Recap: Call for Real Answers to Chronic Fatigue Syndrome | MedPage Today
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: How to Help Yourself | AAFP
Chronic Fatigue Syndrome - National University Of Health Sciences
Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome | The BMJ
Chronic Fatigue Syndrome Archives - Ms. Magazine
Exploring the Link between Chronic Fatigue Syndrome and COVID-19 | goop
Positive Health Online | Article - ME/Chronic Fatigue Syndrome - Under or Misdiagnosed?
Frontiers | Onset Patterns and Course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
What is chronic fatigue syndrome (ME/CFS)?
trauma - Chronic Fatigue Syndrome
Confronting Enigma and Stigma Of Chronic Fatigue Syndrome | Washington Diplomat
Master Enzyme Switch Deactivated In Chronic Fatigue Syndrome and Fibromyalgia
CDC Pushes for More Chronic Fatigue Syndrome Recognition and Research
Chronic fatigue syndrome Information | Mount Sinai - New York
Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Not Just Tired All The Time!
Fibromyalgia Diagnostic Criteria - Chronic Fatigue Syndrome
Myalgic39
- Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, long-term illness that affects many body systems. (cdc.gov)
- Another name for it is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (medlineplus.gov)
- Chronic fatigue syndrome (CFS), also called myalgic encephalomyelitis (ME) or ME/CFS, is a complex, debilitating, long-term medical condition. (wikipedia.org)
- A variety of other names have been used, including myalgic encephalomyelitis (ME), ME/CFS, chronic fatigue immune dysfunction, and most recently, systemic exertion intolerance disease. (medscape.com)
- Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. (medscape.com)
- The diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome should be questioned if patients do not have these symptoms at least half of the time with moderate, substantial, or severe intensity. (medscape.com)
- Chronic fatigue syndrome (CFS) (also called myalgic encephalomyelitis [ME]), is a disorder characterized by unexplained profound fatigue that is worsened by exertion. (medscape.com)
- CFS was originally termed myalgic encephalomyelitis (ME) because British clinicians noted a skeletal muscle component manifesting as chronic fatigue and an encephalitic component manifesting as cognitive difficulties. (medscape.com)
- The illness that has been called "chronic fatigue syndrome" (CFS) in the United States and "myalgic encephalomyelitis" (ME) elsewhere is a "serious, complex, multisystem disease" that physicians need to view as "real" and diagnose, the Institute of Medicine (IOM) says in a new 235-page report. (medscape.com)
- The central point is that ME/CFS is a diagnosis to be made," according to the IOM's report , "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. (medscape.com)
- A brain imaging study of veterans with Gulf War illness (GWI) and patients with chronic fatigue syndrome (CFS) (sometimes called myalgic encephalomyelitis), has shown that the two illnesses produce distinctly different, abnormal patterns of brain activity after moderate exercise. (sciencedaily.com)
- The Cornell Center for Enervating Neuroimmune Disease , established in 2017, ultimately seeks to understand the biological basis and develop a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disabling disorder for which there are currently no effective therapies. (asbmb.org)
- After the Institutes of Medicine had proposed diagnostic criteria for Chronic Fatigue Syndrome, also called Myalgic Encephalomyelitis, we reported on Sept. 11 that advisers to the Department of Health and Human Service (HHS) had recommended increasing funding for the condition. (medpagetoday.com)
- Myalgic encephalomyelitis (my-AL-gic en-SEH-fuhlow-MY-uh-LIE-tus)/chronic fatigue syndrome (ME/CFS) is a chronic, severe, possibly disabling disorder. (aafp.org)
- The time to fight for women with Myalgic Encephalomyelitis-often called Chronic Fatigue Syndrome-who have been dismissed and ignored is now. (msmagazine.com)
- Ami Mac, MD, helps people suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and works to understand the biological basis of the symptoms they experience. (goop.com)
- Eventually that patient was diagnosed with ME/CFS, which stands for myalgic encephalomyelitis/chronic fatigue syndrome. (goop.com)
- Epidemiologic studies of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) have examined different aspects of this disease separately but few have explored them together. (frontiersin.org)
- Myalgic encephalomyelitis/ chronic fatigue syndrome is a complex, disabling, chronic illness that is estimated to affect from 0.76 to 3.28% ( 1 ) of the population worldwide and up to 2.5 million US residents ( 2 ). (frontiersin.org)
- Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a complex condition that affects multiple parts of the body. (bupa.co.uk)
- The exact cause of myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS), is not yet completely understood. (bupa.co.uk)
- Brand new research published in the last few weeks reveals important information for people with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Fibromyalgia (FM). (wellnessresources.com)
- Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Not Just Tired All The Time! (gresham.ac.uk)
- Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a complex and controversial condition that is thought to affect between 0.2 and 0.4% of the UK population (a quarter to half a million). (gresham.ac.uk)
- Our deepest thanks for collaborating with ASSSEM and Irsicaixa in the investigation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (verkami.com)
- Chronic fatigue syndrome is sometimes referred to as CFS, CFIDS, Epstein Barr, myalgic encephalomyelitis, or even Yuppie Flu which is considered offensive. (holistichelp.net)
- Eliza has myalgic encephalomyelitis , more commonly known by the misnomer chronic fatigue syndrome or ME/CFS. (independentaustralia.net)
- As part of a major, multi-institutional, multidisciplinary assault against myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a highly debilitating and poorly understood chronic disease, Jackson Laboratory (JAX) Professor Derya Unutmaz, M.D. , has received a five-year grant totaling $10,553,732 from the National Institutes of Health . (jax.org)
- The Morrison Government is calling for proposals for $3 million in research to better understand the causes and improve diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). (health.gov.au)
- Evidence from previous studies have implicated an important association between gut microbiota (GM) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), but whether there is a definite causal relationship between GM and ME/CFS has not been elucidated. (frontiersin.org)
- Chronic fatigue and immune dysfunction syndrome (CFIDS), sometimes called chronic fatigue syndrome, chronic Epstein-Barr virus (EBV), or myalgic encephalomyelitis, is typically marked by debilitating fatigue, neurologic abnonnalities, and persistent symptoms that suggest chronic mononucleosis. (womens-health-club.com)
- ref>Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Board on the Health of Select Populations, Institute of Medicine. (physio-pedia.com)
- Counting the Cost Chronic Fatigue Syndrome/Myalgic Encephalomyelitis [Internet]. (physio-pedia.com)
- ref>Falk Hvidberg M, Brinth LS, Olesen AV, Petersen KD, Ehlers L. The health-related quality of life for patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). (physio-pedia.com)
- In Diagnosis and Treatment of Chronic Fatigue Syndrome and Myalgic Encephalitis , Dr. Myhill examines this essential role of our mitochondria in energy production and why it is key to understanding and overcoming Chronic Fatigue Syndrome (CFS) and the inflammation that often accompanies it: Myalgic Encephalitis (ME). (bkwrks.com)
- Chronic fatigue syndrome (CFS) is a complex condition that goes by many names, such as chronic fatigue immune dysfunction and myalgic encephalomyelitis. (arizonapain.com)
- Also on May 12, advocates will publicize the health effects of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS), which is a chronic condition marked by persistent, extreme fatigue. (arizonapain.com)
- Blockage of a key metabolic enzyme could explain the profound lack of energy and other symptoms experienced by patients with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS), new research suggests. (medscape.com)
- A substantial percentage of patients with fatigue remain ill for many months with an illness similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ( 5 ), an unexplained syndrome sometimes seen after infections that is characterized by functional limitations that impair patients' ability to maintain daily activities and is associated with profound fatigue ( 6 ). (cdc.gov)
Illness22
- A recent report found that COVID-19 can result in prolonged illness, even among adults without underlying chronic medical conditions. (cdc.gov)
- Chronic fatigue syndrome (CFS) is a complex and serious illness that is often misunderstood. (medscape.com)
- Experts have noted that the terminology "chronic fatigue syndrome" can trivialize this illness and stigmatize persons who experience its symptoms. (medscape.com)
- [ 1 ] The name was coined by a group of clinicians convened by CDC in the late 1980s to develop a research case definition for the illness, which, at the time, was called chronic Epstein-Barr virus syndrome. (medscape.com)
- [ 2 ] However, the fatigue in this illness is striking and quite distinct from the common fatigue everyone experiences. (medscape.com)
- Fatigue: A noticeable decrease or impairment in the ability of a patient to engage in activities that they enjoyed before the onset of the illness, with this impairment continuing for more than 6 months and associated with new-onset severe fatigue, unrelated to exertion, and not relieved by rest. (medscape.com)
- In some persons, the symptoms of CFS develop following an otherwise self-limited illness, such as influenza, infectious mononucleosis, acute cytomegalovirus (cy-to-meg-lo-virus) infections, or a nonspecific acute viral syndrome. (cdc.gov)
- Indeed, panel member Peter Rowe, MD, professor of pediatrics and director of the Chronic Fatigue Clinic at Johns Hopkins Children's Center, Baltimore, Maryland, told Medscape Medical News , "This is an illness that can have a profound impact on people's function, their ability to maintain their jobs or continue their education. (medscape.com)
- Some medical institutions, including the U.S. Department of Veterans Affairs (the VA), list CFS as a symptom of GWI (called chronic multisymptom illness associated with service in the Gulf War by the VA). (sciencedaily.com)
- Curren was thought to have chronic fatigue syndrome (CFS), an illness associated with immune and neurologic symptoms that remains difficult to diagnose. (medpagetoday.com)
- Lucinda Bateman, MD, founder of the Fatigue Consultation Clinic in Salt Lake City told MedPage Today ,"The reason doctors stigmatize the patients is because they don't understand the illness. (medpagetoday.com)
- 9 10 Graded aerobic exercise programmes can reduce incapacity and symptoms in many chronic and painful conditions, such as the post-polio syndrome, 11 chronic back pain, 12 and depressive illness. (bmj.com)
- Laurie Edwards is all too familiar with life in the "kingdom of the sick," which is how cultural critic Susan Sontag famously described the hidden world of chronic illness. (msmagazine.com)
- Ninety-seven percent suffered from at least one other illness: anxiety (48%), depression (43%), fibromyalgia (39%), irritable bowel syndrome (38%), and migraine headaches (37%) were the most diagnosed conditions. (frontiersin.org)
- Severe fatigue accompanied by musculoskeletal pain, headaches, sore throat, tender lymph nodes, concentration/ memory difficulties, unrefreshing sleep, exacerbation of these symptoms with minimal physical, or cognitive exertion (termed post-exertional malaise), and orthostatic intolerance results in patients suffering a substantial reduction in function from their pre-illness state ( 5 , 6 ). (frontiersin.org)
- People with ME/CFS have persistent and profound fatigue and are unable to do activities they were able to do before the illness. (mountsinai.org)
- ME/CFS is a complex, long-term, chronic illness affecting an estimated 250,000 people in the UK. (gresham.ac.uk)
- Among other symptoms, I have the kind of sickly fatigue and malaise that healthy people suffer from when they have an acute illness like the flu-only I've felt this way for 11 1/2 years straight. (lymedisease.org)
- In contrast, "Chronic Fatigue Syndrome" is a debilitating illness that involves a dysfunction of several bodily systems, including the immune system. (lymedisease.org)
- I've succeeded in my efforts: my doctors now use the phrase Chronic Fatigue Syndrome to refer to my illness. (lymedisease.org)
- Chronic fatigue syndrome is a complex illness defined by unexplained disabling fatigue and a combination of non-specific accompanying symptoms. (biomedcentral.com)
- Careful perusal of the Centers for Disease Control and Prevention (CDC) criteria indicates that essentially any chronic illness that produces extensive disability in a setting of persistent fatigue may be included in the differential diagnosis. (medscape.com)
Stigma Of Chronic Fatigue1
- If you'd like, you can read more about CFS (also called ME/CFS) in my two articles, "The Stigma of Chronic Fatigue Syndrome" and "Why Can't Medical Science Figure Out Chronic Fatigue Syndrome? (lymedisease.org)
Illnesses4
- The two illnesses share many symptoms, including cognitive and memory problems (often described as "brain fog"), pain, and fatigue following mild to moderate exercise. (sciencedaily.com)
- A healthcare provider can make the diagnosis of ME/CFS based on a thorough medical history and physical examination, laboratory test results (see Evaluation ), and evaluating for other fatiguing illnesses with a targeted work-up. (cdc.gov)
- I don't write about CFS very often because my focus is on all chronic illnesses and pain conditions. (lymedisease.org)
- The issue explores factors that may increase work-related fatigue and actions to reduce work-related injuries and illnesses. (cdc.gov)
Centers3
- The initial criteria as defined by the US Centers for Disease Control and Prevention (CDC) in 1994 stated that for an individual to be given a diagnosis of CFS they must exhibit symptoms of fatigue or lethargy that must have been causing a 50 per cent loss of physical and social function, for at least six months. (positivehealth.com)
- and medical director of the Fibromyalgia and Fatigue Centers in Hawaii and other U.S. locations like Baltimore, Md. "If you're exhausted and you get a vacation, [when you have CFS] you're not going to feel better. (washdiplomat.com)
- METHODS: Patients who reported persistent fatigue, lowered functional capacity and sickness leave or delayed education after a large community outbreak of giardiasis enteritis in the city of Bergen, Norway were evaluated with the established Centers for Disease Control and Prevention criteria for CFS. (meassociation.org.uk)
Profound4
- 6 months and is accompanied by fatigue, which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion, and is not substantially alleviated by rest. (medscape.com)
- There are very few studies which look at why some people develop the profound fatigue and various symptoms that can last months or years. (positivehealth.com)
- CFS) A debilitating and complex disorder, of unknown cause, characterized by profound fatigue that is not improved by bed rest and may be worsened by physical or mental activity. (lymphnotes.com)
- Symptoms include profound fatigue, cognitive dysfunction, sleep abnormalities and pain, which may vary widely in severity. (jax.org)
Patients39
- Patients with CFS present to the emergency department with a complex list of symptoms, including orthostatic intolerance, fatigue, postexertional malaise (PEM), and diarrhea. (medscape.com)
- Unlike some previous definitions, this is not a diagnosis of exclusion and can be applied to patients who also have other potentially fatiguing conditions. (medscape.com)
- People with chronic fatigue syndrome often have difficulty regulating blood sugar (glucose), resulting in low levels in some CFS patients and elevated levels in others. (psychologytoday.com)
- Cosgrove and De Vlaminck will look for gene activity in muscle fibers, blood vessels and immune cells from the biopsies of ME/CFS patients and controls to see what differences are found in people with the syndrome. (asbmb.org)
- Advocates and patients say "chronic fatigue" is too fluffy a term for a disease so crippling. (medpagetoday.com)
- Lily Chu, MD, an ME/CFS researcher, explained the difference between general fatigue and what patients experience. (medpagetoday.com)
- 66 patients with the chronic fatigue syndrome who had neither a psychiatric disorder nor appreciable sleep disturbance. (bmj.com)
- These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with the chronic fatigue syndrome. (bmj.com)
- Patients with the chronic fatigue syndrome perceive greater fatigue than healthy controls taking the same exercise. (bmj.com)
- 10 Fitness training improved both aerobic capacity and myalgia more than flexibility exercises in patients with the "fibrositis/fibromyalgia syndrome," 13 a condition which overlaps with the chronic fatigue syndrome. (bmj.com)
- 14 A similar training programme improved symptoms and physiological findings in an open study of patients with the "effort syndrome. (bmj.com)
- Patients met the Oxford criteria for the chronic fatigue syndrome. (bmj.com)
- 16 In addition, by using the structured clinical interview for the DSM-III-R ( Diagnostic and Statistical Manual of Mental Disorders , third edition, revised) 17 we excluded patients who also had a current psychiatric disorder or symptomatic insomnia because of the separate effects of these conditions on fatigue. (bmj.com)
- CFS patients report an array of symptoms, including weakness, muscle pain, difficulty remembering and concentrating, insomnia, and fatigue lasting more than 24 hours. (washdiplomat.com)
- Rather, patients must meet a list of criteria, including having severe chronic fatigue for at least six months or longer that impairs normal daily activities. (washdiplomat.com)
- Many patients were described after the First World War and the condition was often referred to as neurasthenia or effort syndrome. (gresham.ac.uk)
- Three patients are presented with post-Q-fever fatigue syndrome. (medscimonit.com)
- Using systems biology approaches, he says, "We now have the opportunity to determine the biological correlations of this chronic disease that can pave the way for precise diagnosis and develop novel therapies to help patients. (jax.org)
- ME/CFS is a complex condition that leaves patients with persistent disabling fatigue, particularly after general activity. (health.gov.au)
- For the first time, researchers have identified biological markers of chronic fatigue in gut bacteria, by studying the stool of patients with chronic fatigue syndrome and patients who are #blessed enough to have normal energy levels. (wellandgood.com)
- One big finding: the patients with chronic fatigue syndrome had less anti-inflammatory bacteria. (wellandgood.com)
- Our work demonstrates that the gut bacterial microbiome in chronic fatigue syndrome patients isn't normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease," says Maureen Hanson, the study's lead researcher, who is also a professor in the department of molecular biology and genetics at Cornell University. (wellandgood.com)
- The aim was to describe the clinical characteristics, disability and employmentloss in a case series of patients with Chronic Fatigue Syndrome (CFS) after the infection. (meassociation.org.uk)
- RESULTS: A total of 58 (60%) out of 96 patients with long-lasting post-infectious fatigue after laboratory confirmed giardiasis were diagnosed with CFS. (meassociation.org.uk)
- When still severely fatigued or disabled after I-CBT, the patients were offered f2f CBT. (jmir.org)
- Disabilities (Sickness Impact Profile -8), physical functioning (Medical Outcomes Survey Short Form-36), psychological distress (Symptom Checklist-90), and proportion of patients with clinically significant improvement in fatigue were the secondary outcomes. (jmir.org)
- Their revised definition of "recovery" was so loose that patients could get worse over the course of the trial on both fatigue and physical function and still be considered "recovered. (thecut.com)
- It is especially important to rule out systemic disorders, particularly lymphoreticular malignancies, in patients who present with fatigue. (medscape.com)
- Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. (medscape.com)
- Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors. (medscape.com)
- Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome. (medscape.com)
- Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus. (medscape.com)
- The literature about treatment of chronic fatigue syndrome (CFS) recommends psychoeducation of patients and their families as a powerful resource against discrimination of probands and worsening of symptoms as pain and fatigue. (bvsalud.org)
- Among COVID-19 patients (15% hospitalized for acute COVID-19), the incidence rate of fatigue was 10.2/100 person-years and the rate of chronic fatigue was 1.8/100 person-years. (cdc.gov)
- Among persons with PCC, fatigue is frequently reported in both hospitalized and nonhospitalized patients ( 2 , 3 ). (cdc.gov)
- A recent prospective cohort study reported 85% of patients who met its PASC definition had fatigue ( 4 ). (cdc.gov)
- Given the central role of fatigue in PCC and the lack of data on incidence of fatigue among patients who have had COVID-19, we conducted a study of incident fatigue diagnoses among patients with and without COVID-19. (cdc.gov)
- and describe deaths and hospitalizations among patients with incident fatigue after SARS-CoV-2 infection. (cdc.gov)
- Endocarditis with negative culture findings and seropositivity (culture positivity and seropositivity or culture negativity and seronegativity are relatively uncommon) is the main clinical presentation of chronic Q fever, usually occurring in patients with preexisting cardiac disease including valve defects, rheumatic heart disease, and prosthetic valves. (medscape.com)
20201
- ME/CFS is a multisystemic disorder and an autoimmune disease, characterized by chronic and recurrent tiredness, which is frequently accompanied by sleep loss, neurocognitive impairment, irritable bowel syndrome, fever, headache, muscle weakness and soreness, and other symptoms ( Sandler and Lloyd, 2020 ). (frontiersin.org)
Immune dysfunction1
- The cause of chronic fatigue and immune dysfunction syndrome is unknown, but researchers suspect that it may be found in HHV-6 or in other herpes viruses,enteroviruses,orretroviruses. (womens-health-club.com)
Symptom4
- One common symptom is severe fatigue . (mountsinai.org)
- will provide an overview of research developments into fatigue, a common and disabling symptom of ME/CFS. (gresham.ac.uk)
- Some people present with FMS or MCS as the primary symptom and chronic fatigue as a secondary symptom. (holistichelp.net)
- Fatigue - This is the primary symptom that CFS is known for as is indicated in the condition's name. (uppercervicalawareness.com)
Fibromyalgia and chronic fatigue2
- Mary Moeller lived with the constant pain of fibromyalgia and chronic fatigue syndrome. (heartlandhealing.com)
- His latest book (2006) is: Fibromyalgia and Chronic Fatigue Syndrome: 7 Proven Steps to Less Pain and More Energy. (iacfsme.org)
Persistent fatigue1
- The name CFS was suggested because of the characteristic persistent fatigue experienced by all those affected and the evidence that acute or reactivated Epstein-Barr virus infection was not associated with many cases. (medscape.com)
Irritable2
- Comorbid conditions are often present and may include: sleep disorders, irritable bowel syndrome, fibromyalgia, depression or anxiety. (cdc.gov)
- Up to 70% of FMS cases show symptoms of irritable bowel syndrome as well. (heartlandhealing.com)
Etiology2
- Thirteen percent came from families where at least one other first-degree relative was also afflicted, rising to 27% when chronic fatigue of unclear etiology was included. (frontiersin.org)
- Chronic fatigue syndrome (CFS) is defined by symptoms and disability, has no confirmatory physical signs or characteristic laboratory abnormalities, and the etiology and pathophysiology remain unknown. (biomedcentral.com)
Disease9
- A Cornell multidisciplinary research center that studies chronic fatigue syndrome has received a five-year, $9.5 million grant from the National Institutes of Health's National Institute of Allergy and Infectious Disease - funding that will enable experts from disparate fields to work together on the mysterious and debilitating condition. (asbmb.org)
- The disease leads to overwhelming fatigue that rest does not alleviate. (asbmb.org)
- It's been estimated that at least 50 percent of those with ME/CFS had a viral or other infection prior to developing long-standing chronic disease. (goop.com)
- Once the mechanism producing the symptoms has been demonstrated then a syndrome tends to be called a disease. (gresham.ac.uk)
- The American Medical Association does consider it a disease for clarification purposes, but like lupus, it is a syndrome. (heartlandhealing.com)
- Chronic fatigue syndrome (CFS) is a disease that was first named in the 1980s. (womens-health-club.com)
- He co-authored the Center for Disease Control Provider Program on Chronic Fatigue Syndrome, several book chapters on CFS/FM, a section on disability for Lexus-Nexus, the IACFS "Primer for Clinical Practitioners," "A Framework for Fibromyalgia Management," as well as two Med Scape programs on diagnosing and treating CFS. (iacfsme.org)
- We've documented, as have others, that the level of functional impairment in people who suffer from CFS [ME/CFS] is comparable to multiple sclerosis, AIDS, end-stage renal failure, [or] chronic obstructive pulmonary disease. (physio-pedia.com)
- There's very little that science knows definitively about chronic fatigue syndrome, a disease characterized by often debilitating physical and mental exhaustion - researchers still haven't been able to identify a cause, let alone a cure. (thecut.com)
Cause of chronic fatigue2
- What is the main cause of chronic fatigue syndrome? (bupa.co.uk)
- Leaky gut" is another cause of chronic fatigue syndrome, according to the new data. (wellandgood.com)
Misnomer1
- But what I've accomplished is small comfort because the consequence of the continued use of the terrible misnomer, "Chronic Fatigue Syndrome," is that an association like the American Academy of Family Physicians can get away with calling me "very tired" and have that information disseminated to its 106,000 members. (lymedisease.org)
20221
- In November 2022, the American Journal of Industrial Medicine (AJIM) published a special issue focusing on work-related fatigue. (cdc.gov)
COVID3
- This study aimed to estimate the incidence rates of post-COVID-19 fatigue and chronic fatigue and to quantify the additional incident fatigue caused by COVID-19. (cdc.gov)
- Compared with non-COVID-19 controls, the hazard ratios were 1.68 (95% CI 1.48-1.92) for fatigue and 4.32 (95% CI 2.90-6.43) for chronic fatigue. (cdc.gov)
- The observed association between COVID-19 and the significant increase in the incidence of fatigue and chronic fatigue reinforces the need for public health actions to prevent SARS-CoV-2 infections. (cdc.gov)
Insomnia3
- Within days she noted an unusual fatigue after minimal activity, then insomnia, achiness in the joints, and generalized muscle pain and weakness. (medscape.com)
- Research points out that insomnia is actually part of the syndrome, not merely present because of the pain associated with it. (heartlandhealing.com)
- The symptoms of chronic fatigue syndrome are marked by excessive, ongoing cognitive and physical fatigue that can't be relieved by any amount of sleep or rest, as well as a variety of other symptoms such as sore throat, flu-like symptoms, muscle pain, digestive problems, insomnia, headaches, fever, and swollen glands. (holistichelp.net)
Treatments4
- researches treatments for Chronic Fatigue Syndrome and fibromyalgia. (psychologytoday.com)
- Over the years, Earth Clinic readers have sent us many reports about their treatments for Chronic Fatigue Syndrome. (earthclinic.com)
- We're going to take you step by step through chronic fatigue syndrome symptoms, causes, and treatments. (uppercervicalawareness.com)
- When talking about chronic fatigue syndrome treatments, please take the word treatment with a grain of salt. (uppercervicalawareness.com)
Findings3
- Revised and expanded, this edition offers the latest findings on chronic fatigue, fibromyalgia, and overlapping diseases such as Gulf War Syndrome. (askjan.org)
- While these findings may not lead to identifying the cause of CFS, it is hopeful that they could eventually lead to a reliable chronic fatigue syndrome test. (uppercervicalawareness.com)
- Taking exception to chronic fatigue syndrome prevalence findings by Price, et al. (cdc.gov)
Exhaustion1
- ME/CFS is described as a living death due to incapacitating fatigue and utter exhaustion," says Mac. (goop.com)
Disability4
- Is chronic fatigue syndrome considered a disability? (bupa.co.uk)
- Chronic fatigue syndrome after Giardia enteritis: clinical characteristics, disability and long-term sickness absence. (meassociation.org.uk)
- Internet-based cognitive behavioral therapy (I-CBT) leads to a reduction of fatigue severity and disability in adults with chronic fatigue syndrome (CFS). (jmir.org)
- The International CFS Study Group also identified ambiguities associated with exclusionary and comorbid conditions and reviewed the standardized, internationally applicable instruments used to measure symptoms, fatigue intensity and associated disability. (biomedcentral.com)
Ailment1
- And to top everything off, with this type of chronic ailment for which there is no set or effective medical or pharmaceutical intervention, there is the specter of clinical depression plaguing those who face day after day of unrelieved pain. (heartlandhealing.com)
Nonspecific symptoms1
- Chronic Fatigue Syndrome, or CFS, comprises a complex of symptoms characterized by chronic, debilitating fatigue and other nonspecific symptoms. (cdc.gov)
Diagnostic criteria1
- This should provide the population using well defined diagnostic criteria, and over time may indicate if the syndrome is stable or increasing in frequency. (cdc.gov)
Acute2
- Q fever is a common and acute but rare chronic zoonosis caused by Coxiella burnetii. (medscimonit.com)
- Its acute form manifests as atypical pneumonia, flu-like syndrome, or hepatitis. (medscimonit.com)
Treatment8
- Now, however, physicians are understanding the overall syndrome and its treatment more clearly. (nuhs.edu)
- Fatigue, functional capacity, and fitness were significantly better after exercise than after flexibility treatment. (bmj.com)
- She has seen many people with this syndrome misdiagnosed with other conditions, and she says effective treatment options are lacking. (goop.com)
- The recommendation of antibiotic treatment in post-Q-fever fatigue syndrome requires further investigation. (medscimonit.com)
- To receive adequate, competent, and respectful treatment for chronic fatigue syndrome, usually requires finding an alternative health doctor such as a holistic medical doctor, an integrative medicine doctor, a functional medicine doctor, a doctor of environmental medicine, or a naturopath. (holistichelp.net)
- Dr. Friedberg is also a psychologist in private practice for 25 years specializing in the treatment of CFS, fibromyalgia, and other chronic pain conditions. (iacfsme.org)
- This study aimed to compare the efficacy of stepped care, using therapist-assisted I-CBT, followed by face-to-face (f2f) cognitive behavioral therapy (CBT) when needed, with f2f CBT (treatment as usual [TAU]) on fatigue severity. (jmir.org)
- Graded exercise is an important chronic fatigue syndrome treatment. (uppercervicalawareness.com)
Symptoms of chronic fatigue5
- What are the symptoms of chronic fatigue syndrome (CFS)? (medlineplus.gov)
- Reduced functional capacity and postexertion fatigue after physical activity are hallmark symptoms of chronic fatigue syndrome (CFS) and may even qualify for biomarker status. (nih.gov)
- The symptoms of chronic fatigue are usually exacerbated with exertion, which is called post-exertional malaise or (PEM). (holistichelp.net)
- As anyone living with the symptoms of chronic fatigue syndrome knows, they would give about anything to have their energy return and live the life they once knew. (holistichelp.net)
- I f the sound of your alarm clock makes you cringe just thinking about it, you're practically using your computer as a pillow by 4 p.m., and you feel too exhausted to make it through your workout, then you're already familiar with the symptoms of chronic fatigue syndrome. (wellandgood.com)
Search1
- I also have chronic fatigue and have had to struggle for many years and search many avenues to keep myself from being totally unable to function. (curezone.com)
Headaches2
- In many cases, chronic headaches are also experienced. (heartlandhealing.com)
- Headaches - Chronic headaches are a frequent issue for CFS sufferers. (uppercervicalawareness.com)
20181
- Muscle fatigue occurs after mild physical exertion and is accompanied by impaired sensory, cognitive, and autonomic functions ( Twisk, 2018 ). (frontiersin.org)
Orthostatic2
- They were also diagnosed with mast cell activation syndrome and postural orthostatic tachycardic syndrome (POTS), which tend to occur along with ME/CFS. (goop.com)
- In children, it is especially important to address the associated autonomic problems such as POTS (Postural Orthostatic Tachycardia Syndrome). (drhoffman.com)
Severity4
- The degree of severity in fatigue and accompanying symptoms can vary greatly from one individual to another. (holistichelp.net)
- Fatigue was self-rated by the Fatigue Severity Scale (FSS). (meassociation.org.uk)
- The primary outcome was fatigue severity (Checklist Individual Strength). (jmir.org)
- Noninferiority was indicated, as the upper boundary of the one-sided 98.75% CI of the difference in the change in fatigue severity between both forms of stepped care and TAU were below the noninferiority margin of 5.2 (4.25 and 3.81, respectively). (jmir.org)
People with chronic1
- Since most people with chronic fatigue present with a weakened immune system, this has become a "chicken or the egg" type battle between researchers with no decisive winner yet. (uppercervicalawareness.com)
Characteristic2
- A characteristic pattern of symptoms and signs is referred to as a syndrome (sometimes a clinical syndrome). (gresham.ac.uk)
- The relentless fatigue is the primary characteristic and is often described as feeling as if there are weights attached to the arms and legs dragging the individual down and making almost any activity feel like a monumental task. (holistichelp.net)
Clinic1
- Chronic fatigue clinic in a general hospital department of psychiatry. (bmj.com)
Extreme fatigue4
- Because symptoms such as extreme fatigue, difficulty concentrating, dizziness, and sleep problems are similar to ME/CFS, researchers are looking into a possible connection between the two conditions. (mountsinai.org)
- I really believe I have this disorder I suffer from extreme fatigue and never knew why and I have been searching for explanations. (lymedisease.org)
- It is characterized by extreme fatigue or tiredness that does not go away with bed rest. (arizonapain.com)
- It is characterized by extreme fatigue that is not improved by resting. (arizonapain.com)
Severely1
- A second test might be necessary to document the atypical recovery response and protracted fatigue possibly unique to CFS, which can severely limit productivity in the home and workplace. (nih.gov)
Cognitive dysfunction1
- The fatigue is accompanied by cognitive dysfunction and impairment of daily functioning that persists for more than 6 months. (medscape.com)
Clinical1
- CONCLUSION: After giardiasis enteritis at least 5% developed clinical characteristics and functional impairment comparable to previously described post-infectious fatigue syndrome. (meassociation.org.uk)
Research4
- ref>Adhopia V. After long-awaited recognition, serious research begins on chronic fatigue syndrome. (physio-pedia.com)
- Trauma - Much research has gone into the idea that physical or emotional trauma can play a role in the onset of chronic fatigue syndrome. (uppercervicalawareness.com)
- The articles identify knowledge gaps and needs as well as future directions for fatigue research. (cdc.gov)
- Validation of biologic markers for use in research on chronic fatigue syndrome. (cdc.gov)
20191
- This issue is a result of discussions and collaborations from the 2019 NIOSH Working Hours, Sleep and Fatigue Forum and also pulls from reports by the National Institute for Occupational Safety and Health (NIOSH) on long work hours and shift work . (cdc.gov)
Fantastic1
- There's a simple distinction," according to Teitelbaum, author of "From Fatigued to Fantastic! (washdiplomat.com)
Inflammation2
- It improves insulin sensitivity, reduces cholesterol and triglyceride production, and suppresses chronic inflammation. (wellnessresources.com)
- For example, a patient presenting to a clinician with a combination of headache, fever, vomiting and neck stiffness has a syndrome that suggests meningitis (inflammation of the covering of the brain- the meninges- usually caused by infection). (gresham.ac.uk)