Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.
A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.
Pyrimidinones are heterocyclic organic compounds that consist of a pyrimidine ring fused with a ketone group, which have significant applications in medicinal chemistry due to their wide range of biological activities, including antibacterial, antiviral, and anticancer properties.
A plant species of the genus VICIA, family FABACEAE. The edible beans are well known but they cause FAVISM in some individuals with GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY. This plant contains vicine, convicine, Vicia lectins, unknown seed protein, AAP2 transport protein, and Vicia faba DNA-binding protein 1.
Glucose-6-Phosphate Dehydrogenase (G6PD) is an enzyme that plays a critical role in the pentose phosphate pathway, catalyzing the oxidation of glucose-6-phosphate to 6-phosphoglucono-δ-lactone while reducing nicotinamide adenine dinucleotide phosphate (NADP+) to nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), thereby protecting cells from oxidative damage and maintaining redox balance.

Favism: divicine hemotoxicity in the rat. (1/26)

Favism is an acute hemolytic anemia known to occur in susceptible individuals who ingest fava beans. Susceptibility to favism is conferred by a genetic deficiency in erythrocytic glucose-6-phosphate dehydrogenase (G6PD) activity. Although the fava bean pyrimidine aglycones, divicine and isouramil, have been implicated in the onset of favism in humans, the lack of a well-defined experimental animal model for favism has hampered progress in elucidating the mechanism underlying hemotoxicity. We have examined whether a favic-like response could be provoked in G6PD-normal rats treated with synthetic divicine. Intraperitoneal administration of divicine to rats preloaded with 51Cr-tagged erythrocytes resulted in a severe, dose-dependent decrease in blood radioactivity (TD50 approximately 0.5 mmol/kg) within 24 h. The increased rate of removal of blood radioactivity was accompanied by a rapid decline in reduced glutathione levels in the blood, decreased hematocrits, marked hemoglobinuria, splenic enlargement, and reticulocytosis. In vitro exposure of 51Cr-tagged red cells to divicine before their re-administration to isologous rats also resulted in a sharp, concentration-dependent decrease in erythrocyte survival in vivo (TC50 approximately 1.5 mM), and these divicine-damaged red cells were removed from the circulation by the spleen. These data demonstrate that a favic response can be induced in G6PD-normal rats treated with divicine, and that hemolytic activity can be reproduced in isolated red cells under conditions that will allow a direct examination of the mechanism underlying this hemotoxicity.  (+info)

Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. (2/26)

Favism is an acute anemic crisis that can occur in susceptible individuals who ingest fava beans. The fava bean pyrimidine aglycone divicine has been identified as a hemotoxic constituent; however, its mechanism of toxicity remains unknown. We have shown recently that divicine can induce a favic-like response in rats and that divicine is directly toxic to rat red cells. In the present study, we have examined the effect of hemotoxic concentrations of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate (HMP) shunt activity, morphology, and membrane skeletal proteins. In vitro exposure of rat red cells to divicine markedly stimulated HMP shunt activity and resulted in depletion of reduced glutathione with concomitant formation of glutathione-protein mixed-disulfides. Examination of divicine-treated red cells by scanning electron microscopy revealed transformation of the cells to an extreme echinocytic morphology. SDS-PAGE and immunoblotting analysis of the membrane skeletal proteins indicated that hemotoxicity was associated with the apparent loss of skeletal protein bands 2.1, 3, and 4.2, and the appearance of membrane-bound hemoglobin. Treatment of divicine-damaged red cells with dithiothreitol reversed the protein changes, which indicated that the observed alterations were due primarily to the formation of disulfide-linked hemoglobin-skeletal protein adducts. The data suggest that oxidative modification of hemoglobin and membrane skeletal proteins by divicine may be key events in the mechanism underlying favism.  (+info)

Acid phosphatases. (3/26)

Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Mystery surrounds the precise functional role of these molecular facilitators, despite much research. Yet, paradoxically, human APs have had considerable impact as tools of clinical investigation and intervention. One particular example is tartrate resistant acid phosphatase, which is detected in the serum in raised amounts accompanying pathological bone resorption. This article seeks to explore the identity and diversity of APs, and to demonstrate the relation between APs, human disease, and clinical diagnosis.  (+info)

Serum lipoprotein pattern as modified in G6PD-deficient children during haemolytic anaemia induced by fava bean ingestion. (4/26)

In the present study, plasma lipid concentrations were determined at different times after admission in sera from G6PD-deficient children during haemolytic crisis induced by fava bean ingestion. Reductions in total, LDL and HDL cholesterol were found in association with the maximum of bone marrow hyperplasia. A return towards normal values occurred with regression of the disease. No changes in other lipid parameters were observed. These data suggest that alterations of lipoprotein pattern, other than in experimental animals, are also present in humans with non-malignant proliferative processes. These changes appear to be a consequence of the disease, probably due to an increased utilization of cholesterol by proliferating cells.  (+info)

An Ashkenazi Jewish woman presenting with favism. (5/26)

The case of a 44 year old Ashkenazi Jewish woman of Russian origin who presented with a typical clinical and haematological picture of favism is reported. There was initial difficulty in confirming glucose-6-phosphate dehydrogenase (G6PD) deficiency because the enzyme concentrations were normal at presentation, but later fell to a concentration compatible with heterozygosity for the Mediterranean type of G6PD deficiency. The diagnosis was also later confirmed by gene analysis. The reasons for the difficulties in the initial confirmation of the diagnosis and the normal G6PD enzyme activity at presentation are discussed.  (+info)

Acute massive haemolysis in children with glucose-6-phosphate dehydrogenase deficiency. (6/26)

We report seven consecutive episodes of acute massive haemolysis accompanied by symptomatic anaemia and gross haemoglobinuria in six boys with glucose-6-phosphate dehydrogenase deficiency seen in a regional hospital during a 12-year period. They presented at a mean age of 5.5 years (range, 1.5-11.3 years) with trough haemoglobin levels between 35 and 84 g/L. Two children developed transient renal impairment. Five children required erythrocyte transfusion, of whom one underwent exchange transfusion during the oliguric phase. Three patients required intensive care but all recovered from the haemolysis. The probable precipitating factors included consumption of fava beans (n=2), exposure to mothballs (n=1), treatment with herbal medicine or intramuscular injection of unknown nature (n=3), and upper respiratory tract infection (n=1). Although uncommon, acute massive haemolysis remains a life-threatening complication in children with glucose-6-phosphate dehydrogenase deficiency. Improvement in patient education and public health measures is suggested.  (+info)

Molecular basis of glutathione reductase deficiency in human blood cells. (7/26)

Hereditary glutathione reductase (GR) deficiency was found in only 2 cases when testing more than 15 000 blood samples. We have investigated the blood cells of 2 patients (1a and 1b) in a previously described family suffering from favism and cataract and of a novel patient (2) presenting with severe neonatal jaundice. Red blood cells and leukocytes of the patients in family 1 did not contain any GR activity, and the GR protein was undetectable by Western blotting. Owing to a 2246-bp deletion in the patients' DNA, translated GR is expected to lack almost the complete dimerization domain, which results in unstable and inactive enzyme. The red blood cells from patient 2 did not exhibit GR activity either, but the patient's leukocytes contained some residual activity that correlated with a weak protein expression. Patient 2 was found to be a compound heterozygote, with a premature stop codon on one allele and a substitution of glycine 330, a highly conserved residue in the superfamily of NAD(P)H-dependent disulfide reductases, into alanine on the other allele. Studies on recombinant GR G330A revealed a drastically impaired thermostability of the protein. This is the first identification of mutations in the GR gene causing clinical GR deficiency.  (+info)

Association between ACP(1) genetic polymorphism and favism. (8/26)

 (+info)

Favism is a genetic disorder that results in a sensitivity to broad beans (Vicia faba) and related plants. It is most commonly found in populations from the Mediterranean, Middle East, and Asia. The disorder is caused by a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD), which is necessary for protecting red blood cells from damage.

When individuals with favism eat broad beans or inhale their pollen, the beans' metabolites can cause the release of harmful oxidative agents that destroy red blood cells, leading to hemolytic anemia. Symptoms of favism can include weakness, fatigue, abdominal pain, dark urine, and jaundice. In severe cases, it can lead to kidney failure, seizures, or even death.

Avoiding broad beans and related plants is the primary treatment for favism. In some cases, blood transfusions or medications that boost red blood cell production may be necessary to manage symptoms. It's important to note that not all people with G6PD deficiency will develop favism, and not all people with favism have G6PD deficiency.

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is a genetic disorder that affects the normal functioning of an enzyme called G6PD. This enzyme is found in red blood cells and plays a crucial role in protecting them from damage.

In people with G6PD deficiency, the enzyme's activity is reduced or absent, making their red blood cells more susceptible to damage and destruction, particularly when they are exposed to certain triggers such as certain medications, infections, or foods. This can lead to a condition called hemolysis, where the red blood cells break down prematurely, leading to anemia, jaundice, and in severe cases, kidney failure.

G6PD deficiency is typically inherited from one's parents in an X-linked recessive pattern, meaning that males are more likely to be affected than females. While there is no cure for G6PD deficiency, avoiding triggers and managing symptoms can help prevent complications.

Pyrimidinones are a class of heterocyclic organic compounds that contain a pyrimidine ring fused with a ketone group. The basic structure of a pyrimidinone consists of two nitrogen atoms and four carbon atoms in a six-membered ring, with a carbonyl (C=O) group attached to one of the carbon atoms.

In a medical context, pyrimidinones are important because many naturally occurring and synthetic compounds that contain this structure have been found to have biological activity. For example, some pyrimidinones have antiviral, antibacterial, or anticancer properties, making them useful in the development of new drugs for various medical conditions.

One well-known drug that contains a pyrimidinone ring is the antiviral medication Ribavirin, which is used to treat hepatitis C and certain viral hemorrhagic fevers. Other pyrimidinones are being studied for their potential therapeutic benefits in areas such as cancer therapy, neuroprotection, and inflammation.

'Vicia faba' is the scientific name for the fava bean plant, which belongs to the legume family (Fabaceae). It is also known as broad bean or horse bean. The plant is widely cultivated as a vegetable crop, and its seeds, pods, and young leaves are all edible. Fava beans are rich in proteins, dietary fiber, vitamins, and minerals, making them an essential component of many diets around the world. However, some people may have an adverse reaction to fava beans due to a genetic disorder called favism, which can cause hemolytic anemia.

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), also known as Glucosephosphate Dehydrogenase, is an enzyme that plays a crucial role in cellular metabolism, particularly in the glycolytic pathway. It catalyzes the conversion of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (1,3-BPG), while also converting nicotinamide adenine dinucleotide (NAD+) to its reduced form NADH. This reaction is essential for the production of energy in the form of adenosine triphosphate (ATP) during cellular respiration. GAPDH has been widely used as a housekeeping gene in molecular biology research due to its consistent expression across various tissues and cells, although recent studies have shown that its expression can vary under certain conditions.

Indications of such a sudden attack of favism are dark urine, pallor, jaundice, abdominal pain and in most cases fever. The β- ... Favism". In Liener, I. (ed.). Toxic constituents of plant foodstuffs. Springer. pp. 293-312. ISBN 9780323147378. Baker MA, ... It causes haemolytic anaemia, called favism. The formation of vicine in Vicia faba has been studied, but this natural formation ... Luzzatto L, Arese P (January 2018). "Favism and Glucose-6-Phosphate Dehydrogenase Deficiency". The New England Journal of ...
Commonly known as "favism", as it can be triggered by chemicals existing naturally in broad (or fava) beans. Theoretically, a ... "Favism - Doctor". patient.info. Archived from the original on 21 November 2017. Retrieved 3 May 2018. X-linked diseases from ...
Favism, or Fava-bean-ism, is a genetic deficiency of the enzyme glucose-6-phosphate dehydrogenase that affects Jews, other ... "Favism - genetic disorder". Encyclopædia Britannica. "Biological Sciences". Biology.ed.ac.uk. Retrieved 21 August 2017. ...
Belsey, Mark A. (1973). "The epidemiology of favism". Bulletin of the World Health Organization. 48 (1): 1-13. ISSN 0042-9686. ... Manifestations and Therapeutic Findings of the Children with Glucose-6-Phosphate Dehydrogenase Deficiency Presenting Favism". ...
... has been deemed a hemotoxic component of fava beans and plays a role in the development of favism, a disorder that ... Symptoms of favism include hemolysis, prolonged jaundice, kernicterus, and even acute renal failure in extreme cases. Divicine ... Luzzatto, Lucio; Arese, Paolo (2018-01-04). Longo, Dan L. (ed.). "Favism and Glucose-6-Phosphate Dehydrogenase Deficiency". New ... called favism. Divicine is also present in and at least partially responsible for the poisonous action of Lathyrus sativus - a ...
Siniscalco, M.; Bernini, L.; Latte, B. (1961). "Favism and thalassaemia in Sardinia and their relationship to malaria". Nature ... Siniscalco, M.; Bernini, L.; Latte, B. (1961). "Favism and thalassaemia in Sardinia and their relationship to malaria". Nature ...
Hedayat also managed research projects on Favism and Endemic Goiter in Iran.[citation needed] Hedayat's pioneering work in ...
... favism) enzymatic deficiency. Methylene blue is a formal derivative of phenothiazine. It is a dark green powder that yields a ...
The seeds contain high levels of vicine, which causes favism amongst susceptible individuals. The habitat of V. bithynica is ...
ISBN 9781606929438 Favism Hemoglobinopathies Malaria and the Red Cell (All articles with dead external links, Articles with ... In Mediterranean countries such individuals can develop a hemolytic diathesis (favism) after consuming fava beans. G6PD ...
Szeinberg A, Sheba C, Hirshorn N, Bodonyi E (July 1957). "Studies on erthrocytes in cases with past history of favism and drug- ...
Though all individuals with favism show G6PD deficiency, not all individuals with G6PD deficiency show favism. The condition is ... Other than this, the specifics of the chemical relationship between favism and G6PD are not well understood.[citation needed] ... ISBN 978-0-8014-4240-7. Family Practice Notebook/G6PD Deficiency (Favism) (Webarchive template wayback links, Articles with ... Very severe crisis can cause acute kidney injury Favism is a hemolytic response to the consumption of fava beans, also known as ...
In the 1950s, this identification was validated and attributed to deficiency of G6PD, and called favism. Although the first ...
Mannuzzu graduated with honors in Medicine from University of Sassari in 1984, with a thesis on favism. She continued her ...
Favism is quite common in Greece because of malaria endemicity in previous centuries, and people afflicted by it do not eat ... Sufferers of favism must avoid broad beans, as they contain the alkaloid glycoside vicine which may initiate a hemolytic crisis ... Some people suffer from favism, a hemolytic response to the consumption of broad beans, a condition linked to a metabolism ...
Razin examined the metabolism of nucleic acids and the biochemical faults in patients with gout and favism. He later studied ...
Drug intolerance Egg intolerance Elimination diet Favism Fructose malabsorption Gluten sensitivity Gluten-sensitive enteropathy ... phenylketonuria and favism. Pharmacological reactions are generally due to low-molecular-weight chemicals which occur either as ...
The reason is unclear: perhaps the flatulence they cause, perhaps as protection from potential favism, but most likely for ...
... may occur in individuals with G6PD deficiency and in individuals with a family or personal history of favism. Areas of high ...
... phenylketonuria and favism. Toxic food reactions are caused by the direct action of a food or additive without immune ...
One example of a conditional lethal is favism, a sex-linked inherited condition that causes the carrier to develop hemolytic ...
In favism, patients lack glucose-6-phosphate dehydrogenase, an enzyme in their pentose phosphate pathway that reduces NADP+ to ... In the same study, glutathione reductase deficiency was associated with cataracts and favism in one patient and their family, ...
... decrease in glucose-6-phosphate dehydrogenase which may results in glucose-6-phosphate dehydrogenase deficiency known as favism ...
... divicine and vicine in quantities sufficient to lower glutathione levels in G6PD-deficient persons to cause favism disease. At ...
... favism MeSH C16.320.070.490 - hemoglobin c disease MeSH C16.320.070.785 - spherocytosis, hereditary MeSH C16.320.070.875 - ...
... favism MeSH C15.378.071.141.150.490 - hemoglobin c disease MeSH C15.378.071.141.150.785 - spherocytosis, hereditary MeSH ... favism MeSH C15.378.071.141.510 - hemoglobinuria MeSH C15.378.071.141.510.460 - hemoglobinuria, paroxysmal MeSH C15.378.071.141 ...
One of the most common diseases among certain ethnic groups in Iran was glucose-6-phosphate dehydrogenase deficiency favism, an ...
... beta thalassemia and favism, multiple sclerosis and coeliac disease. Some other genetic peculiarities have been noted, like the ...
... favism MeSH C21.613.756.558 - lathyrism MeSH C21.613.756.600 - milk sickness MeSH C21.613.809.750 - psychoses, alcoholic MeSH ... favism MeSH C21.613.415.551 - mushroom poisoning MeSH C21.613.415.738 - salmonella food poisoning MeSH C21.613.415.846 - ...
Glucose-6-phosphate dehydrogenase deficiency (G6PD or favism) Pyruvate kinase deficiency Aldolase A deficiency ...
Favism is not a food allergy, neither is it an autoimmune condition, and it can only be considered a food intolerance in that ... Translated, it read: "Warning to customers at risk of acute haemolysis caused by favism: fresh broad beans are displayed and on ... Although I initially stumbled across favism while researching my first book, Living with Food Intolerance, some twenty years ... those affected by favism cannot tolerate broad beans.. The cause is a deficiency of an enzyme called glucose-6-phosphate ...
FAVISM . Share with your dear once Share with your dear once Link. ... 2023, FAVISM Everything on this website has been made with a lots of love and hard work. If you copy anything we will hunt you ...
Indications of such a sudden attack of favism are dark urine, pallor, jaundice, abdominal pain and in most cases fever. The β- ... Favism". In Liener, I. (ed.). Toxic constituents of plant foodstuffs. Springer. pp. 293-312. ISBN 9780323147378. Baker MA, ... It causes haemolytic anaemia, called favism. The formation of vicine in Vicia faba has been studied, but this natural formation ... Luzzatto L, Arese P (January 2018). "Favism and Glucose-6-Phosphate Dehydrogenase Deficiency". The New England Journal of ...
Favism. Feminine hygiene products. Fertilisers and growing media. Fish pedicure. Fish - consumption and nutritional intakes. ...
Acute Favism: Methemoglobinemia May Cause Cyanosis and Low Pulse Oximetry Readings. Leunbach, T. L., Pedersen, J. F., Trydal, T ...
G6PD Deficiency: Favism [Internet]. www.g6pd.org; What is G6PD Deficiency (English); [cited 2021 Apr 23]; [about 3 screens]; ...
Hemolysis after ingestion of fava beans (favism) is most frequently associated with the Mediterranean variant of G6PD ...
Risk factors for G6PD deficiency or favism must be assessed. Baseline hematocrit and hemoglobin must be checked before ... may occur in individuals with G6PD deficiency and in individuals with a family or personal history of favism. Areas of high ...
The third, published in March this year, edited genes associated with the diseases beta thalassemia and favism. This time the ...
Favism:. Favism breaks red blood cells in the body. It may further lead to anaemia, fever, stomach pain, and coma. Someone with ... The seeds of bitter gourd can even cause favism in pregnant women who are already susceptible to anaemia. ... G6PD (a type of glucose) deficiency may develop favism after eating bitter gourd seeds. ...
The importance of plants as agents of illness and disease (including allergies and favism) will also be discussed. PREREQ: BIOL ...
... these compounds lead to favism, a type of anemia. When used in livestock feed, these compounds also detrimentally impact the ...
Important Info : A small percentage of people suffer from favism an allergy to the fava or broad bean, which can be fatal ...
They are particularly used in Middle Eastern cooking (and are the cause of a sometimes fatal allery known as "favism" - a ...
... a condition known as favism. This deficit is most common in people from Africa, followed by those from the Mediterranean and ...
Favism is a disorder that runs in families and is characterized by a deficiency in an enzyme known as glucose-6-phosphate ... While fava beans are a very healthy ingredient, they are not suitable for people who suffer from Favism, otherwise known as a ...
But favism, an inherited enzymatic deficiency occurring among some Jews--mainly those of Kurdish and Iraqi ancestry, many of ...
or favism) that makes him unable to metabolise aspirin, quinine (so no gin and tonic) or anti-malarial drugs, but gives him ...
Dye additionally points out that thats G6PD deficiency, not favism. You have to have G6PD deficiency to get favism, but only a ... Favism destroys red blood cells and is dangerous for young children. The favism theory holds that the Pythagoreans were aware ... In light of that, favism doesnt sound quite as momentous. For our purposes, that is: obviously favism remains a critical ... not favism.. The favism theory doesnt amount to a hill of beans. At best its a mildly interesting speculation. More ...
Pythagoras, fava beans, and favism February 13, 2022 / By Roberta Attanasio Pythagoras-a cloak-wearing mystical leader with a ...
Congenital GR deficiency is associated with acute haemolytic crisis after oxidant drugs of fava beans ingestion (favism). ... Congenital GR deficiency is associated with acute haemolytic crisis after oxidant drugs of fava beans ingestion (favism). In ... favism and severe neonatal jaundice). Cataracts may also be present. ... the only three cases so far reported, favism is always associated with cataracts. ...
... a reaction called favism). Glucose-6-dehydrogenase deficiency is also a significant cause of mild to severe jaundice in ...
... those suffering from the genetic deficiency known as favism), eating raw broad beans can provoke a serious allergic reaction ( ...
... may have a genetic predisposition to favism, an enzyme deficiency that can cause a severe reaction to raw beans and pollen. If ...
... favism, heart failure.Before having surgery, tell your doctor or dentist about all the products you use (including prescription ...
G-6-PD deficiency; Hemolytic anemia due to G6PD deficiency; Favism. Classification. *Defects of phagocyte function ...
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
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  • Although I initially stumbled across favism while researching my first book, Living with Food Intolerance , some twenty years ago, I hadn't realised it could pose such a risk to those those with acute G6PD deficiency. (allergy-insight.com)
  • Risk factors for G6PD deficiency or favism must be assessed. (nih.gov)
  • Hemolytic reactions (moderate to severe) may occur in individuals with G6PD deficiency and in individuals with a family or personal history of favism. (nih.gov)
  • In humans with the G6PD genetic deficiency, these compounds lead to favism, a type of anemia. (saskpulse.com)
  • Clinical manifestations of GR deficiency are very similar to that of glucose-6-phosphate dehydrogenase (G6PD) deficiency (favism and severe neonatal jaundice). (enerca.org)
  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. (krystexxa.com)
  • Accuracy of Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency Depending on Clinical Manifestations of Favism. (edu.ly)
  • 11. Known significant glucose-6-phosphate dehydrogenase deficiency (favism, acute hemolytic anemia) (for systemic ozone therapy). (who.int)
  • Congenital GR deficiency is associated with acute haemolytic crisis after oxidant drugs of fava beans ingestion (favism). (enerca.org)
  • Many Italian cities have launched ordinances banning the cultivation of fava beans inside tons of of meters of colleges or the properties of the weak, as some favism victims say a mere whiff of the insidious fava pollen can set off an assault. (thebusinessnext.com)
  • Favism is a severe reaction to fava beans and or their pollen. (seeds-gallery.com)
  • But one of the most sensible explanations is the fact that in some people (those suffering from the genetic deficiency known as favism), eating raw broad beans can provoke a serious allergic reaction (severe haemolytic anaemia) and could lead to death. (cooksister.com)
  • Metabolic food reactions are due to inborn or acquired errors of metabolism of nutrients, such as in lactase deficiency, phenylketonuria and favism. (olsreview.com)
  • Vicine and convicine are anti-nutritional compounds that when present in high levels can give rise to favism in humans (those that have a deficiency in the activity of a particular enzyme) and can give performance issues when fed in animal feeds. (farmersguide.co.uk)
  • The importance of plants as agents of illness and disease (including allergies and favism) will also be discussed. (laurentian.ca)
  • Favism is not a food allergy, neither is it an autoimmune condition, and it can only be considered a food intolerance in that those affected by favism cannot 'tolerate' broad beans. (allergy-insight.com)
  • Important Info : A small percentage of people suffer from 'favism' an allergy to the 'fava' or 'broad' bean, which can be fatal. (backyardgardener.com)
  • That can cause favism in people who have a variant glucose-6-phosphate dehydrogenase. (seeds-gallery.com)
  • G6PD Deficiency: Favism [Internet]. (medlineplus.gov)
  • Risk factors for G6PD deficiency or favism must be assessed. (nih.gov)
  • Hemolytic reactions (moderate to severe) may occur in individuals with G6PD deficiency and in individuals with a family or personal history of favism. (nih.gov)
  • have a rare blood problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency or favism. (krystexxa.com)
  • There is a hereditary condition, Favism, which causes an allergic-like reaction to fava or broad beans . (foodreference.com)
  • Favism, named after the fava bean, is a hereditary disease that can cause significant levels of hemolysis. (perfusiontheory.com)
  • In this later case, the disorder is known as favism . (bvsalud.org)
  • Indications of such a sudden attack of favism are dark urine, pallor, jaundice, abdominal pain and in most cases fever. (wikipedia.org)
  • People with favism react to external factors that trigger jaundice during babyhood the most. (gurmebebek.com)
  • In a review of 67 cases of favism over a 3-year period by a physician in Cyprus, 2 of the cases were breastfed infants, aged 5 and 9 months. (nih.gov)
  • What is Favism?It is a genetic disease. (oxxo.life)
  • Favism by proxy in nursing glucose-6-phosphate dehydrogenase-deficient neonates. (nih.gov)
  • Favism can cause anemia by destroying red blood cells ( 15 , 16 , 17 ). (healthline.com)
  • Favism via breastmilk can be quite severe. (nih.gov)
  • It should not be used in cases with favism disease, widespread infection, thyroid dysfunction, and pregnant women. (profdrokanbalcioglu.com)
  • Such an association is likely coincidental because favism is common among individuals from the family's place of origin. (medscape.com)
  • An estimated, 30,000 to 40,000 black male G6PDD babies, a high risk group for favism, are born annually in the United States (2). (perfusiontheory.com)
  • The purpose of this site is to offer the reader a background information on favism. (g6pd.org)
  • While all effort has been made to ensure that the information offered as part of this site is correct and up-to-date, neither the authors of included content, nor the Associazione Italiana Favism - Deficit di G6PD, which created the site, nor the volunteers who are now administering it, and third party information providers warrant that the information is accurate and complete. (g6pd.org)