A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.
A characteristic symptom complex.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Enlargement of the spleen.
Surgical procedure involving either partial or entire removal of the spleen.

Human triclonal anti-IgG gammopathy. I. Iso-electric focusing characteristics of the IgG, IgA and IgM anti-IgG and their heavy and light chains. (1/66)

Human IgG, IgA and IgM anti-IgG autoantibodies have been isolated from the serum of an individual with Felty's syndrome. These were initially noted as soluble circulating serum complexes by analytical ultracentrifugation. Isolation was accomplished by solid phase immunoadsorption and each of the three antibody populations obtained was shown to be of restricted heterogeneity by liquid and polyacrylamide gel electrofocussing methods. Type kappa light chains were obtained from each protein. Co-isoelectric focusing experiments of all possible pairs of these light chains showed them to have identical net charge characteristics. Heavy chains obtained from each protein were also monoclonal and of differing isoelectric point. The availability of this serum provides a human model with which to study the changes which may occur in autoantibodies during the autoimmune response.  (+info)

Defective responsiveness to ascorbic acid of neutrophil random and chemotactic migration in Felty's syndrome and systemic lupus erythematosus. (2/66)

Polymorphonuclear (PMN) leucocytes from 4 patients with untreated systemic lupus erythematosus (SLE) showed defective random migration (P less than 0-05) and depressed chemotactic responses to C5a and kallikrein (P less than 0-01) compared to PMN leucocytes from normal subjects, or patients with rheumatoid arthritis (4) or Felty's syndrome (4) when examined at a standardized cell concentration with a micropore filter radioassay but not with a conventional Boyden technique. Normal in vitro enhancement of PMN leucocyte random and chemotactic migration by sodium ascorbate was absent in SLE and Felty's syndrome, but sodium ascorbate gave normal stimulation of hexose monophosphate shunt activity in the PMN leucocytes precluding a defect in ascorbate transport.  (+info)

A Fas promoter polymorphism at position -670 in the enhancer region does not confer susceptibility to Felty's and large granular lymphocyte syndromes. (3/66)

OBJECTIVE: We examined whether there are associations between a polymorphism in the Fas promoter, recently found to be associated with rheumatoid arthritis (RA), and Felty's syndrome or large granular lymphocyte (LGL) leukaemia. METHODS: Thirty-five patients with Felty's were studied, along with 18 patients with LGL syndrome and arthritis, 17 patients with LGL syndrome but no arthritis, and 128 controls. The polymorphism was typed by polymerase chain reaction followed by digestion with the restriction enzyme MvaI. RESULTS: No significant difference was found in genotype or allele frequencies between the groups. CONCLUSION: This promoter polymorphism is not a significant risk factor responsible for the LGL expansions seen in Felty's and LGL syndromes. Abnormal, constitutive expression of Fas ligand may be more relevant to the aetiology of these diseases.  (+info)

CD8+, CD57+ T cells from healthy elderly subjects suppress neutrophil development in vitro: implications for the neutropenia of Felty's and large granular lymphocyte syndromes. (4/66)

OBJECTIVE: To investigate the ability of CD8+,CD57+ large granular lymphocytes (LGL) from normal individuals and from Felty's syndrome (FS) or LGL syndrome patients to suppress allogeneic neutrophil precursor development. METHODS: Six FS patients, 5 LGL syndrome patients, and 13 elderly controls were studied. CD8+,CD57+ T cells were cocultured with cord blood-derived stem cells, and percentage inhibition was calculated. Recombinant chemokines and Fas-stimulating molecules were used in separate cultures to address possible mechanisms of suppression. Proliferation after stimulation with interleukin-2 (IL-2) and anti-CD3 was assessed. RESULTS: Significant (79%) suppression of colony-forming unit-granulocyte-macrophage (CFU-GM) by the CD8+,CD57+ subset was shown by 1 FS patient. None of the CD8+,CD57+ cells from LGL syndrome patients had any effect. Six of 13 controls studied showed >40% inhibition of CFU-GM, and all but 2 showed at least some suppression. The suppressive effect was not mediated by Fas/Fas ligand interactions or by the chemokines macrophage inhibitory protein 1alpha or IL-8. LGL from both patients and controls were largely CD28- and had reduced proliferative capacity. CONCLUSION: In a subset of FS patients, expansion of CD8+,CD57+ T cells in the bone marrow may be responsible for neutropenia by suppressing neutrophil precursors. This effect is also seen with normal LGL, which are likely to have an important function in neutrophil homeostasis.  (+info)

Major histocompatility complex haplotypic associations in Felty's syndrome and large granular lymphocyte syndrome are secondary to allelic association with HLA-DRB1 *0401. (5/66)

OBJECTIVE: To investigate the role of HLA class I in susceptibility to Felty's syndrome (FS) and large granular lymphocyte (LGL) syndrome. METHODS: Fifty caucasoid FS patients, and 55 patients with LGL syndrome, of whom 26 had arthritis and 29 did not, were studied. Complete HLA class I and HLA-DR typing including, where relevant, DRB1*04 subtyping was carried out by molecular methods. Comparison was made with 78 unselected healthy caucasoid controls and a further 29 DRB1*0401+ individuals. RESULTS: A significant association was found between HLA-A*02 and FS [odds ratio (OR) 3.9, 95% confidence interval (95% CI) 1.8-8.4, P = 0.0004]. At the B locus, there was an association between B*44 and LGL with arthritis [OR 3.5 (1.3-9.2), P = 0.01]. For HLA-Cw*0501, there was an association with FS [OR 4 (1. 7-9.2) P = 0.0008]. For both FS and LGL with arthritis, the extended haplotype HLA-A*02;B*44;Cw*0501;DRB1*0401 was significantly associated [OR 9.5 (2.6-35), P = 0.0001; OR 4.6 (1-22.4), P = 0.05, respectively]. There was no association between HLA class I or II and LGL without arthritis. All the allelic and haplotypic associations were lost on comparison with HLA-DRB1*0401+ controls. The strongest HLA association was with HLA-DRB1*0401 for FS [OR 27.9 (10.3-75.5), P = 10(-13)], and LGL with arthritis [OR 35.4 (9.6-131. 3), P = 10(-10)]. CONCLUSIONS: The major histocompatibility locus (MHC) associations with FS reported here are due to linkage disequilibrium with HLA-DRB1*0401. LGL syndrome with arthritis shows identical class II associations with FS, although there may be subtle immunogenetic differences between the two in the class I region. One of the extended haplotypes reported in a number of studies for FS and rheumatoid arthritis (summarized as HLA-A*02;Cw*0501; B*44;TNFb5;TNFa6;TNFd4;C4A*3;C4BQ*0;DRB1*0 401;DQB1*0301) is likely to be attributable to strong primary association with HLA-DRB1*0401, rather than to epistatic interaction between these loci.  (+info)

Cloning and expression of a novel human antibody-antigen pair associated with Felty's syndrome. (6/66)

An increasing number of studies suggest the importance of antibodies in the pathogenesis of most systemic and organ-specific autoimmune diseases, although there is considerable controversy over the precise role of the autoantibodies involved. In humans, a major obstacle to progress is the identification and cloning of the relevant autoantibodies and autoantigens. Here, an approach based on the sequential use of antibody phage display and antigen expression libraries is developed and applied to a donor suffering from rheumatoid arthritis (RA), splenomegaly, and peripheral destruction of neutrophils leading to neutropenia (Felty's syndrome). An antibody phage display library was constructed from bone marrow from the donor and a high-affinity human mAb, ANA15, selected by panning against fresh neutrophils and independently by panning against a fixed cell line. The antibody showed strong staining of neutrophils and a number of cell lines. Probing of a lambdagt11 expression library from an induced myelomonocytic cell line with the mAb ANA15 identified the eukaryotic elongation factor 1A-1 (eEF1A-1) as a novel autoantigen. The specificity of ANA15 was confirmed by reactivity with both purified and recombinant eEF1A-1. Screening of a large panel of sera revealed that 66% of patients with Felty's syndrome had elevated levels of anti-eEF1A-1 antibodies. The cloning of this antibody-antigen pair should permit rational evaluation of any pathogenicity resulting from the interaction and its significance in neutropenia.  (+info)

Depression of bone marrow colony formation in gold-induced neutropenia. (7/66)

Bone marrow culture in semi-solid agar was used to assess the proliferative activity and the response to sodium aurothiomalate of the myeloid precursor cells from patients during and after recovery from neutropenia associated with the use of this drug. Colony formation was reduced during the neutropenia and returned to normal after recovery. The rheumatoid process itself did not impair colony formation even in patients with Felty's syndrome. Sodium aurothiomalate inhibited colony formation by normal marrow in a dose-dependent manner. Bone marrow colonies from patients who had recovered from neutropenia induced by sodium aurothiomalate were not abnormally sensitive to the inhibitory effect of the drug in vitro. The metabolism of gold is probably altered in a small proportion of patients, which causes high local concentrations within the bone marrow leading directly to marrow depression.  (+info)

Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. (8/66)

Understanding of the genetic basis of autoimmune diseases is currently incomplete. Cytokine gene polymorphisms warrant consideration as factors explaining variation in the human immune and inflammatory responses and as candidate susceptibility genes for related pathological states. Interleukin 12 (IL-12) is a key regulator of the polarisation of immune responses to T helper 1 or 2 categories and plays a role in autoimmune and infectious diseases. Using a bioinformatic strategy, we aligned cDNA and expressed sequence tag sequences to identify putative polymorphic regions of the IL-12 p40 gene. Position 1188 in the 3' untranslated region (UTR) was polymorphic with the frequency of the common allele around 80% in healthy UK Caucasoids. PCR genotyping of multiple Caucasoid groups and an African group showed significant population variation. In a case-control design, the polymorphism was not associated with rheumatoid arthritis, Felty's syndrome or large granular lymphocyte syndrome with arthritis or multiple sclerosis. A nonsignificant increase in the B allele frequency was observed in the rare large granular lymphocyte syndrome without arthritis (odds ratio 2.02 95% CI 0.95-4.3). This new genetic marker could be useful in anthropological studies and should be investigated in other autoimmune, allergic, inflammatory and infectious diseases.  (+info)

Felty syndrome is a rare complication that can occur in people with long-standing chronic inflammatory arthritis, specifically those with rheumatoid arthritis. It is characterized by the triad of rheumatoid arthritis, an enlarged spleen (splenomegaly), and a decrease in white blood cell count (neutropenia). The neutropenia can lead to an increased risk of infections. Additionally, some people with Felty syndrome may also develop other symptoms such as fatigue, weakness, fever, and a purple rash on the legs (purpura).

The exact cause of Felty syndrome is not fully understood, but it is thought to be related to an abnormal immune response in people with rheumatoid arthritis. Treatment typically involves medications to manage the symptoms and control the underlying rheumatoid arthritis, such as disease-modifying anti-rheumatic drugs (DMARDs) and/or immunosuppressive therapies. In some cases, removal of the spleen (splenectomy) may be recommended to help improve the neutropenia and reduce the risk of infections.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Down syndrome is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is characterized by intellectual and developmental disabilities, distinctive facial features, and sometimes physical growth delays and health problems. The condition affects approximately one in every 700 babies born in the United States.

Individuals with Down syndrome have varying degrees of cognitive impairment, ranging from mild to moderate or severe. They may also have delayed development, including late walking and talking, and may require additional support and education services throughout their lives.

People with Down syndrome are at increased risk for certain health conditions, such as congenital heart defects, respiratory infections, hearing loss, vision problems, gastrointestinal issues, and thyroid disorders. However, many individuals with Down syndrome live healthy and fulfilling lives with appropriate medical care and support.

The condition is named after John Langdon Down, an English physician who first described the syndrome in 1866.

Metabolic syndrome, also known as Syndrome X, is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes. It is not a single disease but a group of risk factors that often co-occur. According to the American Heart Association and the National Heart, Lung, and Blood Institute, a person has metabolic syndrome if they have any three of the following five conditions:

1. Abdominal obesity (waist circumference of 40 inches or more in men, and 35 inches or more in women)
2. Triglyceride level of 150 milligrams per deciliter of blood (mg/dL) or greater
3. HDL cholesterol level of less than 40 mg/dL in men or less than 50 mg/dL in women
4. Systolic blood pressure of 130 millimeters of mercury (mmHg) or greater, or diastolic blood pressure of 85 mmHg or greater
5. Fasting glucose level of 100 mg/dL or greater

Metabolic syndrome is thought to be caused by a combination of genetic and lifestyle factors, such as physical inactivity and a diet high in refined carbohydrates and unhealthy fats. Treatment typically involves making lifestyle changes, such as eating a healthy diet, getting regular exercise, and losing weight if necessary. In some cases, medication may also be needed to manage individual components of the syndrome, such as high blood pressure or high cholesterol.

Nephrotic syndrome is a group of symptoms that indicate kidney damage, specifically damage to the glomeruli—the tiny blood vessel clusters in the kidneys that filter waste and excess fluids from the blood. The main features of nephrotic syndrome are:

1. Proteinuria (excess protein in urine): Large amounts of a protein called albumin leak into the urine due to damaged glomeruli, which can't properly filter proteins. This leads to low levels of albumin in the blood, causing fluid buildup and swelling.
2. Hypoalbuminemia (low blood albumin levels): As albumin leaks into the urine, the concentration of albumin in the blood decreases, leading to hypoalbuminemia. This can cause edema (swelling), particularly in the legs, ankles, and feet.
3. Edema (fluid retention and swelling): With low levels of albumin in the blood, fluids move into the surrounding tissues, causing swelling or puffiness. The swelling is most noticeable around the eyes, face, hands, feet, and abdomen.
4. Hyperlipidemia (high lipid/cholesterol levels): The kidneys play a role in regulating lipid metabolism. Damage to the glomeruli can lead to increased lipid production and high cholesterol levels in the blood.

Nephrotic syndrome can result from various underlying kidney diseases, such as minimal change disease, membranous nephropathy, or focal segmental glomerulosclerosis. Treatment depends on the underlying cause and may include medications to control inflammation, manage high blood pressure, and reduce proteinuria. In some cases, dietary modifications and lifestyle changes are also recommended.

Sjögren's syndrome is a chronic autoimmune disorder in which the body's immune system mistakenly attacks its own moisture-producing glands, particularly the tear and salivary glands. This can lead to symptoms such as dry eyes, dry mouth, and dryness in other areas of the body. In some cases, it may also affect other organs, leading to a variety of complications.

There are two types of Sjögren's syndrome: primary and secondary. Primary Sjögren's syndrome occurs when the condition develops on its own, while secondary Sjögren's syndrome occurs when it develops in conjunction with another autoimmune disease, such as rheumatoid arthritis or lupus.

The exact cause of Sjögren's syndrome is not fully understood, but it is believed to involve a combination of genetic and environmental factors. Treatment typically focuses on relieving symptoms and may include artificial tears, saliva substitutes, medications to stimulate saliva production, and immunosuppressive drugs in more severe cases.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. It is characterized by persistent inflammation, synovial hyperplasia, and subsequent damage to the articular cartilage and bone. The immune system mistakenly attacks the body's own tissues, specifically targeting the synovial membrane lining the joint capsule. This results in swelling, pain, warmth, and stiffness in affected joints, often most severely in the hands and feet.

RA can also have extra-articular manifestations, affecting other organs such as the lungs, heart, skin, eyes, and blood vessels. The exact cause of RA remains unknown, but it is believed to involve a complex interplay between genetic susceptibility and environmental triggers. Early diagnosis and treatment are crucial in managing rheumatoid arthritis to prevent joint damage, disability, and systemic complications.

Agranulocytosis is a medical condition characterized by an abnormally low concentration of granulocytes (a type of white blood cells) in the peripheral blood. Granulocytes, which include neutrophils, eosinophils, and basophils, play a crucial role in the body's defense against infections. A significant reduction in their numbers can make an individual highly susceptible to various bacterial and fungal infections.

The condition is typically defined as having fewer than 150 granulocytes per microliter of blood or less than 1% of the total white blood cell count. Symptoms of agranulocytosis may include fever, fatigue, sore throat, mouth ulcers, and susceptibility to infections. The condition can be caused by various factors, including certain medications, medical treatments (such as chemotherapy or radiation therapy), autoimmune disorders, and congenital conditions. Immediate medical attention is required for individuals diagnosed with agranulocytosis to prevent and treat potential infections and restore the normal granulocyte count.

Splenomegaly is a medical term that refers to an enlargement or expansion of the spleen beyond its normal size. The spleen is a vital organ located in the upper left quadrant of the abdomen, behind the stomach and below the diaphragm. It plays a crucial role in filtering the blood, fighting infections, and storing red and white blood cells and platelets.

Splenomegaly can occur due to various underlying medical conditions, including infections, liver diseases, blood disorders, cancer, and inflammatory diseases. The enlarged spleen may put pressure on surrounding organs, causing discomfort or pain in the abdomen, and it may also lead to a decrease in red and white blood cells and platelets, increasing the risk of anemia, infections, and bleeding.

The diagnosis of splenomegaly typically involves a physical examination, medical history, and imaging tests such as ultrasound, CT scan, or MRI. Treatment depends on the underlying cause and may include medications, surgery, or other interventions to manage the underlying condition.

A splenectomy is a surgical procedure in which the spleen is removed from the body. The spleen is an organ located in the upper left quadrant of the abdomen, near the stomach and behind the ribs. It plays several important roles in the body, including fighting certain types of infections, removing old or damaged red blood cells from the circulation, and storing platelets and white blood cells.

There are several reasons why a splenectomy may be necessary, including:

* Trauma to the spleen that cannot be repaired
* Certain types of cancer, such as Hodgkin's lymphoma or non-Hodgkin's lymphoma
* Sickle cell disease, which can cause the spleen to enlarge and become damaged
* A ruptured spleen, which can be life-threatening if not treated promptly
* Certain blood disorders, such as idiopathic thrombocytopenic purpura (ITP) or hemolytic anemia

A splenectomy is typically performed under general anesthesia and may be done using open surgery or laparoscopically. After the spleen is removed, the incision(s) are closed with sutures or staples. Recovery time varies depending on the individual and the type of surgery performed, but most people are able to return to their normal activities within a few weeks.

It's important to note that following a splenectomy, individuals may be at increased risk for certain types of infections, so it's recommended that they receive vaccinations to help protect against these infections. They should also seek medical attention promptly if they develop fever, chills, or other signs of infection.

Brief biography of Felty: "Augustus Roi Felty", Whonamedit? See also: "Felty's syndrome", Whonamedit? Felty, A. R. (1924). " ... Felty's syndrome (FS), also called Felty syndrome, is rare autoimmune disease characterized by the triad of rheumatoid ... "CIGNA - Felty's Syndrome". Retrieved 2008-11-07. "HowStuffWorks "Felty's Syndrome - Medical Dictionary"". Archived from the ... Felty's syndrome may remain undiagnosed. In more rare instances, the development of Felty's syndrome may precede the ...
"Immune complexes and the pathogenesis of neutropenia in Felty's syndrome". Annals of the Rheumatic Diseases. 45 (8): 696-702. ... Some, such as chronic fatigue syndrome, are controversial. These conditions are included here because they are frequently ... Murinson BB (2004). "Stiff-person syndrome". Neurologist. 10 (3): 131-7. doi:10.1097/01.nrl.0000126587.37087.1a. PMID 15140273 ... "POEMS syndrome: definitions and long-term outcome". Blood. 101 (7): 2496-506. doi:10.1182/blood-2002-07-2299. PMID 12456500. ...
This isoform is identified as an autoantigen in 66% of patients with Felty's syndrome. This gene has been found to have ...
He obtained his PhD at Leiden University in 1985, with a dissertation titled: "Felty syndrome". Breedveld was a professor of ...
Increased CD57+ counts have also been reported in rheumatoid arthritis and Felty's syndrome, among other conditions. High ... "Collagen type IX and HNK-1 epitope in tears of patients with pseudoexfoliation syndrome". Biochimica et Biophysica Acta (BBA ...
Felty syndrome Systemic lupus erythematosus HIV/AIDS infection Glycogen storage disease Cohen syndrome Congenital immune ... Other causes of congenital neutropenia are Shwachman-Diamond syndrome, Cyclic neutropenia, bone marrow failure syndromes, ... deficiency Barth syndrome Copper deficiency Vitamin B12 deficiency Pearson syndrome Some types of Hermansky-Pudlak syndrome ... Bone marrow biopsies can also be used to monitor the development of myelodysplastic syndrome (MDS) or acute myeloid leukemia ( ...
Rheumatoid arthritis is commonly observed in people with T-LGLL, leading to a clinical presentation similar to Felty's syndrome ...
A low white blood cell count usually only occurs in people with Felty's syndrome with an enlarged liver and spleen. The ... The most common problem is carpal tunnel syndrome caused by compression of the median nerve by swelling around the wrist. ... Other, rather rare, skin associated symptoms include pyoderma gangrenosum, Sweet's syndrome, drug reactions, erythema nodosum, ... Caplan's syndrome describes lung nodules in individuals with RA and additional exposure to coal dust. Exudative pleural ...
In 70% of patients with rheumatoid arthritis, Felty's syndrome, Sjogren's syndrome, systemic sclerosis, and primary biliary ... but are also implicated in other autoimmune diseases like Sjögren syndrome, dermatomyositis, or rheumatoid arthritis. Anti- ...
Systemic lupus erythematosus Felty's syndrome Still's disease Drug hypersensitivity as Hydantoin, Hydralazine, Allopurinol Misc ...
... a set of attribute-value pairs Felty's syndrome, autoimmune disease, with rheumatoid arthritis, enlargement of the spleen and ...
Felty's syndrome MeSH C20.111.199.774 - Sjögren syndrome MeSH C20.111.199.856 - spondylitis, ankylosing MeSH C20.111.199.870 - ... Guillain-Barré syndrome MeSH C20.111.258.750.400.500 - Miller Fisher syndrome MeSH C20.111.258.750.600 - hereditary sensory and ... Sézary syndrome MeSH C20.683.515.950 - tumor lysis syndrome MeSH C20.683.780.250 - cryoglobulinemia MeSH C20.683.780.490 - ... Schnitzler syndrome MeSH C20.683.780.650 - multiple myeloma MeSH C20.683.780.750 - POEMS syndrome MeSH C20.683.780.925 - ...
Polyoma BK virus nephropathy Kimura's disease Systemic lupus erythematosus Felty's syndrome Takayasu arteritis Granulomatosis ... Stevens-Johnson syndrome, cutaneous lupus erythematosus, severe infection, interstitial lung disease, cirrhosis and liver ...
Fechtner syndrome Feigenbaum-Bergeron-Richardson syndrome Feigenbaum-Bergeron syndrome Feingold syndrome Felty's syndrome ... syndrome Fraser-Jequier-Chen syndrome Fraser-like syndrome Fraser syndrome Frasier syndrome FRAXA syndrome FRAXD FRAXE syndrome ... syndrome Frenkel-Russe syndrome Frey's syndrome Frias syndrome Fried-Goldberg-Mundel syndrome Friedel-Heid-Grosshans syndrome ... Ashenazi syndrome Frydman-Cohen-Karmon syndrome Fryer syndrome Fryns-Fabry-Remans syndrome Fryns-Hofkens-Fabry syndrome Fryns- ...
Felty's syndrome MeSH C17.300.775.099.683 - rheumatoid nodule MeSH C17.300.775.099.774 - Sjögren syndrome MeSH C17.300.775.099. ... Tietze syndrome MeSH C17.300.200.310 - Ehlers-Danlos syndrome MeSH C17.300.200.425 - keloid MeSH C17.300.200.425.125 - acne ... Stevens-Johnson syndrome MeSH C17.800.229.413 - erythema nodosum MeSH C17.800.229.413.800 - Sweet's syndrome MeSH C17.800. ... leopard syndrome MeSH C17.800.621.430.530.550.625 - Peutz-Jeghers syndrome MeSH C17.800.621.440 - hypopigmentation MeSH C17.800 ...
... syndrome Feingold syndrome Feline hyperesthesia syndrome Felty's syndrome Femur fibula ulna syndrome Fetal alcohol syndrome ... syndrome Wende-Bauckus syndrome Werner syndrome Wernicke-Korsakoff syndrome West syndrome Westerhof syndrome Wet lung syndrome ... syndrome Shone's syndrome Short anagen syndrome Short bowel syndrome short limb syndrome Short man syndrome Short QT syndrome ... syndrome Radial tunnel syndrome Rage syndrome Raghib syndrome Raine syndrome Ramos-Arroyo syndrome Ramsay Hunt syndrome type 1 ...
Felty's syndrome MeSH C05.550.114.154.683 - rheumatoid nodule MeSH C05.550.114.154.774 - Sjögren syndrome MeSH C05.550.114.154. ... Caplan's syndrome MeSH C05.799.114.389 - Felty's syndrome MeSH C05.799.114.683 - rheumatoid nodule MeSH C05.799.114.774 - ... Klippel-Feil syndrome MeSH C05.116.099.370.652 - orofaciodigital syndromes MeSH C05.116.099.370.797 - Rubinstein-Taybi syndrome ... Hajdu-Cheney syndrome MeSH C05.116.099.105 - basal-cell nevus syndrome MeSH C05.116.099.343 - dwarfism MeSH C05.116.099.343.110 ...
Felty's syndrome Juvenile idiopathic arthritis Adult-onset Still's disease Crystal arthropathy Gout Chondrocalcinosis ...
Sidney Farber Felty's syndrome - Augustus Roi Felty Fitz-Hugh-Curtis syndrome - Thomas Fitz-Hugh Jr., Arthur Hale Curtis Foix- ... Hakaru Hashimoto Havisham syndrome (a.k.a. Diogenes syndrome, Miss Havisham syndrome, and Plyushkin syndrome) - Miss Havisham, ... Havisham syndrome, Miss Havisham syndrome, Plyushkin syndrome)- Diogenes of Sinope (the particular usage, Diogenes syndrome, is ... syndrome - Moritz Simmonds Sipple's syndrome - John H. Sipple Sjögren syndrome - Henrik Sjögren Sjögren-Larsson syndrome - ...
Vella A, Carlson LA, Blier B, Felty C, Kuiper JD, Rooke TW (2000). "Circulator boot therapy alters the natural history of ... Abdul W, Hickey B, Wilson C (April 2016). "Lower extremity compartment syndrome in the setting of iliofemoral deep vein ... phantom eye syndrome). A similar phenomenon is unexplained sensation in a body part unrelated to the amputated limb. It has ... can cause compartment syndrome and gangrene Cancerous bone or soft tissue tumors (e.g. osteosarcoma, chondrosarcoma, ...
Roy D, Sarkar S, Felty Q (January 2006). "Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells". Frontiers ... Increased production of IL-1β causes a number of different autoinflammatory syndromes, most notably the monogenic conditions ... and approved in many countries for treatment of cryopyrin-associated periodic syndromes. Rilonacept is an IL-1 trap developed ... referred to as Cryopyrin-Associated Periodic Syndromes (CAPS), due to mutations in the inflammasome receptor NLRP3 which ...
Brief biography of Felty: "Augustus Roi Felty", Whonamedit? See also: "Feltys syndrome", Whonamedit? Felty, A. R. (1924). " ... Feltys syndrome (FS), also called Felty syndrome, is rare autoimmune disease characterized by the triad of rheumatoid ... "CIGNA - Feltys Syndrome". Retrieved 2008-11-07. "HowStuffWorks "Feltys Syndrome - Medical Dictionary"". Archived from the ... Feltys syndrome may remain undiagnosed. In more rare instances, the development of Feltys syndrome may precede the ...
Felty syndrome is a disorder that includes rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and ... Felty syndrome is a disorder that includes rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and ... The cause of Felty syndrome is unknown. It is more common in people who have had rheumatoid arthritis (RA) for a long time. ... Felty syndrome is a disorder that includes rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and ...
Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive ... encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape ... Felty Syndrome. Updated: Jul 19, 2022 * Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD more... ... One case of Feltys syndrome efficiently treated with rituximab. Joint Bone Spine. 2012 Mar 6. [QxMD MEDLINE Link]. ...
ICD-10 code M05.05 for Feltys syndrome, hip is a medical classification as listed by WHO under the range -Inflammatory ... ICD-10-CM Code for Feltys syndrome, hip M05.05 ICD-10 code M05.05 for Feltys syndrome, hip is a medical classification as ... Feltys syndrome, hip M05. Excludes1: rheumatic fever (I00). juvenile rheumatoid arthritis (M08.-). rheumatoid arthritis of ...
Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive ... encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape ... Felty Syndrome. Updated: Jul 19, 2022 * Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD more... ... One case of Feltys syndrome efficiently treated with rituximab. Joint Bone Spine. 2012 Mar 6. [QxMD MEDLINE Link]. ...
Felty syndrome was first described in 1924.. What is Felty Syndrome. According to Definitionexplorer, felty syndrome affects ... As a special form of rheumatoid arthritis, direct prevention of Feltys syndrome is unfortunately not possible. Felty syndrome ... the causes of invasive inflammatory joint changes in Feltys syndrome are still largely in the dark. Since Feltys syndrome, in ... Felty syndrome does not reduce life expectancy. However, the syndrome increases the risk of accidents and falls at home and at ...
Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive ... encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape ... Felty Syndrome Differential Diagnoses. Updated: Feb 12, 2014 * Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert ... One case of Feltys syndrome efficiently treated with rituximab. Joint Bone Spine. 2012 Mar 6. [QxMD MEDLINE Link]. ...
Incidence of cancer among men with the Felty syndrome.. G Gridley, J H Klippel, R N Hoover, J F Fraumeni. Annals of Internal ... Hospital records confirmed the diagnoses of the Felty syndrome and cancer.. RESULTS: We observed a twofold increase in total ... CONCLUSION: The increased risk for non-Hodgkin lymphoma after the Felty syndrome in our study is similar to the risk associated ... PATIENTS: 906 men with a discharge diagnosis of the Felty syndrome.. MEASUREMENTS: Standardized incidence ratios (SIR) (ratios ...
Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive ... encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape ... Felty Syndrome. Updated: Feb 12, 2014 * Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD more... ... One case of Feltys syndrome efficiently treated with rituximab. Joint Bone Spine. 2012 Mar 6. [QxMD MEDLINE Link]. ...
title = "Spontaneous remission of feltys syndrome",. abstract = "The clinical course of a patient with Felty syndrome is ... syndrome. Then a spontaneous remission began. During the subsequent 6 years, neither symptoms nor signs of Felty syndrome have ... syndrome. Then a spontaneous remission began. During the subsequent 6 years, neither symptoms nor signs of Felty syndrome have ... syndrome. Then a spontaneous remission began. During the subsequent 6 years, neither symptoms nor signs of Felty syndrome have ...
The treatment of Feltys syndrome is based on using classic synthetic and biological disease-modifying drugs (DMARDs). In this ... A triad of symptoms characterises Feltys syndrome: seropositive rheumatoid arthritis (RA), splenomegaly and neutropenia. ... The treatment of Feltys syndrome is based on using classic synthetic and biological disease-modifying drugs (DMARDs). In this ... Feltys syndrome (FS) is a rare systemic connective tissue disease. It is characterised by a triad of symptoms: seropositive ...
What is Feltys syndrome?. It is a rare complication of rheumatoid arthritis in which there is leukopenia with selective ... lymphocyte, may mimic Feltys syndrome in rheumatoid arthritis.. Note. Splenectomy does not prevent sepsis and may hasten the ... Augustus R. Felty (1895-1964) was a physician at Hartford Hospital, Hartford, Connecticut. He described this syndrome while he ... This patient has moderate splenomegaly with rheumatoid arthritis (lesions) due to Feltys syndrome. ...
Neutropenias in Feltys syndrome and systemic lupus erythematosus. / Akhtari, Mojtaba; Waller, Edmund K. Twenty Years of G-CSF ... Neutropenias in Feltys syndrome and systemic lupus erythematosus. In Molineux G, Arvedson T, Foote M, editors, Twenty Years of ... title = "Neutropenias in Feltys syndrome and systemic lupus erythematosus",. author = "Mojtaba Akhtari and Waller, {Edmund K ... Akhtari, M & Waller, EK 2012, Neutropenias in Feltys syndrome and systemic lupus erythematosus. in G Molineux, T Arvedson & M ...
ICD-10-CM code M05.03 for Feltys syndrome, wrist - Non-billable ... M05.05 Feltys syndrome, hip. *M05.051 Feltys syndrome, right ... M05.03 is a non-billable ICD-10 code for Feltys syndrome, wrist. It should not be used for HIPAA-covered transactions as a ... for Feltys syndrome, wrist. These codes can be used for all HIPAA-covered transactions. ... M05.00 Feltys syndrome, unspecified site. *. M05.01 Feltys syndrome, shoulder. *M05.011 Feltys syndrome, right shoulder ...
The subsequent clinical course often mirrors that of the Waterhouse-Friderichsen syndrome, with bilateral adrenal hemorrhages ... Overwhelming postsplenectomy infection (OPSI), also known as postsplenectomy sepsis syndrome, begins as a nonspecific, flulike ... and clinical evidence of disseminated intravascular coagulation-thus making this syndrome a true medical emergency. ...
Felty syndrome. Splenomegaly, neutropenia, and thrombocytopenia. Nervous system. Cervical myelopathy. Caused by C1-C2 ... Secondary Sjögren syndrome, dry mouth may also occur. Peripheral ulcerative keratitis. More severe scleritis, if untreated can ... Caplan syndrome. Nodules and pneumoconiosis (e.g., in coal miners). Interstitial lung disease. May resemble bronchiolitis ...
Feltys Syndrome. *Rheumatoid Lung. *Psoriatic Arthritis. *Plaque Psoriasis. *Non-Radiographic Axial Spondyloarthritis ... numbness or tingling, or a nervous system disorder such as multiple sclerosis or Guillain-Barré syndrome; or ... for UTITurmeric BenefitsPomegranate Juice BenefitsHypothyroidism DietWasp Stings TreatmentAshwagandha BenefitsSkeeter Syndrome ...
Feingold syndrome + Feingold Trainer Syndrome Feline Acquired Immunodeficiency Syndrome Feltys syndrome Female Athlete Triad ... urofacial syndrome + A syndrome that is characterized by inverted facial expressions in association with a severe and early- ... Cerebellar Vermis Aplasia with Associated Features suggesting Smith-Lemli-Opitz Syndrome and Meckel Syndrome ... urofacial syndrome (DOID:0050816). Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (2) Bonobo: (2) Dog: (2) Squirrel: ( ...
Feltys syndrome (M05.0). juvenile dermatomyositis (M33.0-). psoriatic juvenile arthropathy (L40.54). Code also: any associated ...
When these problems occur together, it is called Feltys syndrome. Inflammation can also affect the blood vessels (vasculitis ... Down Syndrome: Helping Your Child Learn to Walk and Use Other Motor Skills ...
1.2.3. Autoimmune disorders (SLE, RA/Felty syndrome). 1.2.4. Malignancies (lymphomas, MPN) ...
Feltys syndrome or other systemic involvement); comorbidity including prior outpatient infection, prior hospitalised infection ...
Felty Syndrome. *Fibromyalgia. *Holding the neck in one position too long. *Japanese encephalitis ...
Felty syndrome, Sjögren syndrome Sjögren Syndrome Sjögren syndrome is a relatively common chronic, autoimmune, systemic, ... Carpal tunnel syndrome Carpal Tunnel Syndrome Carpal tunnel syndrome is compression of the median nerve as it passes through ... Neutropenia occurs in 1 to 2% of cases, often with splenomegaly (Felty syndrome). Acute-phase reactants (eg, thrombocytosis, ... Felty syndrome, Sjögren syndrome, scleromalacia, and episcleritis. ...
Chandra PA, Margulis Y, Schiff C. Rituximab is useful in the treatment of Feltys syndrome. American Journal of Therapeutics. ... "Lithium-unmasked Brugada Syndrome." Preeti A. Chandra, MD; Abhinav B. Chandra, MD.. Research Poster Presentation at Heart ... "Unmasking of Brugada syndrome by Lithium." Chandra PA, Chandra AB. Research poster presentation at the Society of Hospital ... Nerella N, Lodha A, Tiu CT, Chandra PA, Rose M. Thromboembolism in Takotsubo Syndrome: A case report. International Journal of ...
Felty syndrome is a syndrome of rheumatoid arthritis, splenomegaly, and neutropenia. Splenectomy produces an initial response, ... In individuals with neutropenia and Felty syndrome who have recurrent, life-threatening bacterial infections, splenectomy is ... Treatment of severe neutropenia due to Feltys syndrome or systemic lupus erythematosus with granulocyte colony-stimulating ... Most cases of Shwachman-Diamond syndrome are caused by mutations in the SBDS gene. [30] The precise function of this gene is ...
Arthritis (Septic arthritis, Reactive arthritis, Rheumatoid arthritis, Psoriatic arthritis, Feltys syndrome, Juvenile ... Polyarteritis nodosa - Churg-Strauss syndrome - Kawasaki disease - Hypersensitivity vasculitis - Goodpastures syndrome - ... synovium and tendon: Synovitis - Tenosynovitis (Stenosing tenosynovitis, Trigger finger, DeQuervains syndrome) bursitis ( ... Juvenile osteochondrosis (Legg-Calvé-Perthes syndrome, Osgood-Schlatter disease, Köhler disease, Severs disease) - ...
Feltys Syndrome: Causes, Symptoms, Treatment- Azathioprine, Methotrexate, Surgery. Pramod Kerkar, M.D., FFARCSI, DA - ...
Feltys syndrome, Kostmanns syndrome, Shwachman-Diamond syndrome, neutropenias of the autoimmune, isoimmune, chronic ...
Feltys Syndrome. RA in association with splenomegaly and neutropenia is known as Feltys syndrome. Thrombocytopenia also may ... Thrombocytopenia also may be observed in Feltys syndrome or vasculitis.. Although leukopenia is associated with Feltys ... Feltys syndrome, Sjögrens syndrome, rheumatoid lung findings, erosions on radiograph), bone erosions, and positive rheumatoid ... Patients with Feltys syndrome and severe leukopenia are more susceptible to infection. The decrease in granulocytes appears to ...
  • Felty's syndrome (FS), also called Felty syndrome, is rare autoimmune disease characterized by the triad of rheumatoid arthritis, enlargement of the spleen and low neutrophil count. (wikipedia.org)
  • The symptoms of Felty's syndrome are similar to those of rheumatoid arthritis. (wikipedia.org)
  • in this case, Felty's syndrome may remain undiagnosed. (wikipedia.org)
  • In more rare instances, the development of Felty's syndrome may precede the development of the symptoms and physical findings associated with rheumatoid arthritis. (wikipedia.org)
  • Felty's syndrome is also characterized by an abnormally enlarged spleen (splenomegaly) and abnormally low levels of certain white blood cells (neutropenia). (wikipedia.org)
  • Individuals with Felty's syndrome may also experience fever, weight loss, and/or fatigue. (wikipedia.org)
  • Recurrent infection Enlargement of the spleen causing too few red blood cells and platelets in the bloodstream Enlarged lymph nodes Skin hyperpigmentation Cutaneous ulceration The cause of Felty's syndrome is unknown, but it has been found to be more common in those with chronic rheumatoid arthritis. (wikipedia.org)
  • The underlying pathogenesis of Felty's syndrome is not clear. (wikipedia.org)
  • In Felty's syndrome, chronic activation of neutrophils progresses to neutropenia and unabated infections. (wikipedia.org)
  • Successful treatment of refractory neutropenia in Felty's syndrome with rituximab. (medlineplus.gov)
  • The Felty's syndrome is a disease of the rheumatic form circle. (electronicsmatter.com)
  • In Felty's syndrome, those affected regularly suffer from severe rheumatic pain and restricted mobility. (electronicsmatter.com)
  • As with most rheumatic diseases, the causes of invasive inflammatory joint changes in Felty's syndrome are still largely in the dark. (electronicsmatter.com)
  • Since Felty's syndrome, in contrast to rheumatoid arthritis, is a rare variant of rheumatism, according to the German Rheumatism League there is a lack of public funding, which is urgently needed for research into the cause. (electronicsmatter.com)
  • With advancing age, patients with rheumatoid arthritis are more likely to develop Felty's syndrome. (electronicsmatter.com)
  • More recent research results allow the conclusion that Felty's syndrome could be an autoimmune disease, i.e. the organism produces antibodies against the body's own cartilage and bone structures, which in turn leads to an inflammatory reaction. (electronicsmatter.com)
  • Felty's syndrome also increases the patient's susceptibility to infections, so that they get sick more often and suffer from various infections and inflammations. (electronicsmatter.com)
  • Autoantibodies against granulocyte colony-stimulating factor in Felty's syndrome and neutropenic systemic lupus erythematosus. (medscape.com)
  • Etanercept in treatment of Felty's syndrome. (medscape.com)
  • Treatment of Felty's syndrome with leflunomide. (medscape.com)
  • Salazosulfapyridine-induced remission of Felty's syndrome along with significant reduction in neutrophil-bound immunoglobulin G. J Rheumatol . (medscape.com)
  • Lack of efficacy of rituximab in Felty's syndrome. (medscape.com)
  • Chandra PA, Margulis Y, Schiff C. Rituximab is useful in the treatment of Felty's syndrome. (medscape.com)
  • One case of Felty's syndrome efficiently treated with rituximab. (medscape.com)
  • Biological agents in the management of Felty's syndrome: a systematic review. (medscape.com)
  • A triad of symptoms characterises Felty's syndrome: seropositive rheumatoid arthritis (RA), splenomegaly and neutropenia. (termedia.pl)
  • The treatment of Felty's syndrome is based on using classic synthetic and biological disease-modifying drugs (DMARDs). (termedia.pl)
  • In this article, we present a case of a patient with Felty's syndrome who was treated with biologic treatment. (termedia.pl)
  • Felty's syndrome (FS) is a rare systemic connective tissue disease. (termedia.pl)
  • This patient has moderate splenomegaly with rheumatoid arthritis (lesions) due to Felty's syndrome. (syrianclinic.com)
  • What is Felty's syndrome? (syrianclinic.com)
  • lymphocyte, may mimic Felty's syndrome in rheumatoid arthritis. (syrianclinic.com)
  • Akhtari, M & Waller, EK 2012, Neutropenias in Felty's syndrome and systemic lupus erythematosus . (nebraska.edu)
  • Waller, Edmund K. / Neutropenias in Felty's syndrome and systemic lupus erythematosus . (nebraska.edu)
  • M05.03 is a non-billable ICD-10 code for Felty's syndrome, wrist . (icd10coded.com)
  • When these problems occur together, it is called Felty's syndrome. (healthlinkbc.ca)
  • Felty's syndrome or malaria. (the-medical-dictionary.com)
  • 10 felty's syndrome.tw. (arthritisdaily.net)
  • Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. (medlineplus.gov)
  • Burks EJ, Loughran TP Jr. Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. (medscape.com)
  • Felty syndrome is characterized by the triad of long-standing, aggressive rheumatoid arthritis (RA), neutropenia, and splenomegaly. (basicmedicalkey.com)
  • Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive (rheumatoid factor [RF]-positive) rheumatoid arthritis (RA). (medscape.com)
  • Felty syndrome was first described in 1924. (electronicsmatter.com)
  • The myelodysplastic syndromes (MDS) include a heterogeneous group of clonal bone marrow failure syndromes characterized by cytopenias, clonally restricted hematopoiesis (associated with an abnormal G-banded metaphase karyotype in about 50% of cases), genomic instability, and a risk of progression to acute myeloid leukemia (AML). (dermatologyadvisor.com)
  • Are you sure your patient has a myelodysplastic syndrome? (dermatologyadvisor.com)
  • These disorders can be classified as systemic, affecting multiple organs or tissues (e.g., connective tissue autoimmune diseases such as systemic lupus erythematosus [ SLE ], Sjögren syndrome [ SjS ], or scleroderma), or organ specific, targeting one particular organ. (basicmedicalkey.com)
  • In most cases women are affected by Felty syndrome, in men the disease occurs largely less often and leads to fewer complications and complaints. (electronicsmatter.com)
  • This patient was unusual because during a 3‐year period of splenomegaly and leukopenia she did not develop repeated infections, leg ulcers, or other complications of Felty' syndrome. (elsevierpure.com)
  • Hospital records confirmed the diagnoses of the Felty syndrome and cancer. (qxmd.com)
  • This syndrome is mostly present in people having extra articular manifestations of rheumatoid arthritis. (wikipedia.org)
  • Felty syndrome is a disorder that includes rheumatoid arthritis , a swollen spleen, decreased white blood cell count , and repeated infections. (medlineplus.gov)
  • Before patients were diagnosed with Felty Syndrome, they had previously had rheumatoid arthritis. (electronicsmatter.com)
  • Felty syndrome occurs in less than 1 percent of cases of so-called uncomplicated rheumatoid arthritis. (electronicsmatter.com)
  • Brücker R, Schlumpf U. [Felty syndrome: a therapy-resistant variant of chronic rheumatoid arthritis? (medscape.com)
  • A handout on this topic is available at http://familydoctor.org/familydoctor/en/diseases-conditions/rheumatoid-arthritis.html . (aafp.org)
  • 8 arthritis, juvenile rheumatoid/ 9 caplan's syndrome.tw. (arthritisdaily.net)
  • Beneficial response to rituximab in refractory Felty Syndrome. (medscape.com)
  • To estimate the incidence of cancer (especially lymphoproliferative malignancies) in patients with the Felty syndrome. (qxmd.com)
  • According to the guidelines of the German Society for Rheumatology, the diagnosis of Felty Syndrome may only be made if a triad of symptoms can be clinically determined. (electronicsmatter.com)
  • There is an average of more than 12 years between the first onset of polyarthritis and the diagnosis of Felty syndrome. (electronicsmatter.com)
  • In order to make the diagnosis of Felty syndrome, the clinical manifestation of a so-called triad is essential. (electronicsmatter.com)
  • The diagnosis of Felty Syndrome is usually not made in a family doctor's practice, but rather by a rheumatologist. (electronicsmatter.com)
  • 906 men with a discharge diagnosis of the Felty syndrome. (qxmd.com)
  • Felty syndrome is diagnosed as a special form of polyarthritis by rheumatism experts. (electronicsmatter.com)
  • Incidence of cancer among men with the Felty syndrome. (medscape.com)
  • Not every affected patient develops the clinical signs of Felty syndrome over time. (electronicsmatter.com)
  • The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. (medscape.com)
  • The clinical course of a patient with Felty' syndrome is described. (elsevierpure.com)
  • Keratoconjunctivitis sicca may occur due to secondary Sjögren's syndrome. (wikipedia.org)
  • During the subsequent 6 years, neither symptoms nor signs of Felty' syndrome have recurred. (elsevierpure.com)
  • Nervous system (e.g., myasthenia gravis [a disorder of the neuromuscular junction], multiple sclerosis, Guillain-Barré Syndrome, autoimmune autonomic failure). (basicmedicalkey.com)
  • Nearly all people with Felty syndrome have a positive test for rheumatoid factor. (medlineplus.gov)
  • The splenic condition involving Felty syndrome is more specifically noted as inflammatory splenomegaly. (wikipedia.org)
  • Felty syndrome affects around 7 percent of patients with vasculitis. (electronicsmatter.com)
  • In the case of Felty syndrome, industrious patients experience severe restrictions on movement. (electronicsmatter.com)
  • Augustus R. Felty (1895-1964) was a physician at Hartford Hospital, Hartford, Connecticut. (syrianclinic.com)
  • People with this syndrome are at risk of infection because they have a low white blood cell count. (wikipedia.org)
  • The increased risk for non-Hodgkin lymphoma after the Felty syndrome in our study is similar to the risk associated with the Sjögren syndrome and may reflect similar immunostimulatory mechanisms. (qxmd.com)