Infections with viruses of the family FILOVIRIDAE. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.
A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.
An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.
A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.
A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.

Filoviral haemorrhagic fevers. (1/38)

Sensationalised accounts of wards of dying patients have fueled intense public fascination with filoviruses and highlighted the global threat of emerging and re-emerging infectious diseases. Filoviruses are the prototypical emerging pathogens: they cause a haemorrhagic disease of high case-fatality associated with explosive outbreaks due to person-to-person transmission, have no known treatment, occur unpredictably, and have an unknown reservoir. In truth, since their initial discovery in 1967, only a handful of filoviral outbreaks have occurred, mostly in remote locations. However, the documented occurrence of secondary cases in locations far from endemic areas validates the concern that filoviruses have the potential to cause unprecedented outbreaks in the future.  (+info)

The role of the Type I interferon response in the resistance of mice to filovirus infection. (2/38)

Adult immunocompetent mice inoculated with Ebola (EBO) or Marburg (MBG) virus do not become ill. A suckling-mouse-passaged variant of EBO Zaire '76 ('mouse-adapted EBO-Z') causes rapidly lethal infection in adult mice after intraperitoneal (i.p.) inoculation, but does not cause apparent disease when inoculated subcutaneously (s.c.). A series of experiments showed that both forms of resistance to infection are mediated by the Type I interferon response. Mice lacking the cell-surface IFN-alpha/beta receptor died within a week after inoculation of EBO-Z '76, EBO Sudan, MBG Musoke or MBG Ravn, or after s.c. challenge with mouse-adapted EBO-Z. EBO Reston and EBO Ivory Coast did not cause illness, but immunized the mice against subsequent challenge with mouse-adapted EBO-Z. Normal adult mice treated with antibodies against murine IFN-alpha/beta could also be lethally infected with i.p.-inoculated EBO-Z '76 or EBO Sudan and with s.c.-inoculated mouse-adapted EBO-Z. Severe combined immunodeficient (SCID) mice became ill 3-4 weeks after inoculation with EBO-Z '76, EBO Sudan or MBG Ravn, but not the other viruses. Treatment with anti-IFN-alpha/beta antibodies markedly accelerated the course of EBO-Z '76 infection. Antibody treatment blocked the effect of a potent antiviral drug, 3-deazaneplanocin A, indicating that successful filovirus therapy may require the active participation of the Type I IFN response. Mice lacking an IFN-alpha/beta response resemble primates in their susceptibility to rapidly progressive, overwhelming filovirus infection. The outcome of filovirus transfer between animal species appears to be determined by interactions between the virus and the innate immune response.  (+info)

Ecologic and geographic distribution of filovirus disease. (3/38)

We used ecologic niche modeling of outbreaks and sporadic cases of filovirus-associated hemorrhagic fever (HF) to provide a large-scale perspective on the geographic and ecologic distributions of Ebola and Marburg viruses. We predicted that filovirus would occur across the Afrotropics: Ebola HF in the humid rain forests of central and western Africa, and Marburg HF in the drier and more open areas of central and eastern Africa. Most of the predicted geographic extent of Ebola HF appear to have been observed; Marburg HF has the potential to occur farther south and east. Ecologic conditions appropriate for Ebola HF are also present in Southeast Asia and the Philippines, where Ebola Reston is hypothesized to be distributed. This first large-scale ecologic analysis provides a framework for a more informed search for taxa that could constitute the natural reservoir for this virus family.  (+info)

Ebola and Marburg virus-like particles activate human myeloid dendritic cells. (4/38)

The filoviruses, Ebola (EBOV) and Marburg (MARV), are potential global health threats, which cause deadly hemorrhagic fevers. Although both EBOV and MARV logarithmically replicate in dendritic cells (DCs), these viruses do not elicit DC cytokine secretion and fail to activate and mature infected DCs. Here, we employed virus-like particles (VLPs) of EBOV and MARV to investigate whether these genome-free particles maintain similar immune evasive properties as authentic filoviruses. Confocal microscopy indicated that human myeloid-derived DCs readily took up VLPs. However, unlike EBOV and MARV, VLPs induced maturation of DCs including upregulation of costimulatory molecules (CD40, CD80, CD86), major histocompatibility complex (MHC) class I and II surface antigens, and the late DC maturation marker CD83. The chemokine receptors CCR5 and CCR7 were also modulated on VLP-stimulated DCs, indicating that DC could migrate following VLP exposure. Furthermore, VLPs also elicited DC secretion of the pro-inflammatory cytokines TNF-alpha, IL-8, IL-6, and MIP-1alpha. Most significantly, in stark contrast to DC treated with intact EBOV or MARV, DC stimulated with EBOV or MARV VLPs showed enhanced ability to support human T-cell proliferation in an allogenic mixed lymphocyte response (MLR). Thus, our findings suggest that unlike EBOV and MARV, VLPs are effective stimulators of DCs and have potential in enhancing innate and adaptive immune responses.  (+info)

Potential mammalian filovirus reservoirs. (5/38)

Ebola and Marburg viruses are maintained in unknown reservoir species; spillover into human populations results in occasional human cases or epidemics. We attempted to narrow the list of possibilities regarding the identity of those reservoir species. We made a series of explicit assumptions about the reservoir: it is a mammal; it supports persistent, largely asymptomatic filovirus infections; its range subsumes that of its associated filovirus; it has coevolved with the virus; it is of small body size; and it is not a species that is commensal with humans. Under these assumptions, we developed priority lists of mammal clades that coincide distributionally with filovirus outbreak distributions and compared these lists with those mammal taxa that have been tested for filovirus infection in previous epidemiologic studies. Studying the remainder of these taxa may be a fruitful avenue for pursuing the identity of natural reservoirs of filoviruses.  (+info)

Dendritic cells in viral pathogenesis: protective or defective? (6/38)

Dendritic cells (DC) are potent antigen-presenting cells that are critical in the initiation of immune responses to control and/or eliminate viral infections. Recent studies have investigated the effects of virus infection on the biology of DC. This review summarizes these changes, focusing on both the DC parameters affected and the viral factors involved. In addition, the central role of DC biology in the pathogenesis of several viral families, including herpesviruses, paramyxoviruses and retroviruses, is explored. The field of pathogen recognition by DC is addressed, focusing on its role in protecting the host from viral infection, as well as the ability of viruses to exploit such host receptor ligation and signalling to their replicative advantage. The hypothesis is proposed that virus and host have evolved a symbiotic relationship to ensure both viral transmission and host survival.  (+info)

Rapid molecular strategy for filovirus detection and characterization. (7/38)

Filoviruses have the capacity to cause lethal outbreaks of hemorrhagic fever in primates. Here we present a simple consensus reverse transcription-PCR method for filovirus recognition and characterization and demonstrate its utility with all known filovirus strains. Phylogenetic assignment is achieved by automated web-based sequence analysis of amplification products.  (+info)

Outbreaks of filovirus hemorrhagic fever: time to refocus on the patient. (8/38)

In the 40 years since the recognition of filoviruses as agents of lethal human disease, there have been no specific advances in antiviral therapies or vaccines and few clinical studies on the efficacy of supportive care. On 20 September 2006, experts from 14 countries representing 68 institutions integrally involved in the response to outbreaks of filovirus hemorrhagic fever gathered at the National Microbiology Laboratory of the Public Health Agency of Canada in Winnipeg to discuss possible remedies for this grim situation, in a unique workshop entitled "Marburg and Ebola Hemorrhagic Fever: Feasibility of Prophylaxis and Therapy." A summary of the opportunities for and challenges to improving treatment of filovirus hemorrhagic fevers is presented here.  (+info)

Filoviridae infections refer to diseases caused by viruses belonging to the Filoviridae family, which includes Ebola virus and Marburg virus. These viruses are characterized by filamentous or threadlike shapes and can cause severe hemorrhagic fever in humans and primates. The infections are associated with high mortality rates, ranging from 25% to 90%, depending on the specific virus and strain.

Transmission of Filoviridae viruses occurs through direct contact with infected bodily fluids or contaminated surfaces. The initial symptoms of infection include fever, muscle pain, headache, and sore throat, followed by vomiting, diarrhea, rash, and impaired organ function. In severe cases, the disease can progress to hemorrhagic fever, characterized by internal and external bleeding, shock, and multi-organ failure.

Currently, there are no approved vaccines or antiviral treatments for Filoviridae infections, although several experimental therapies and vaccines are under development. Prevention measures include avoiding contact with infected individuals, practicing good hygiene, and using personal protective equipment when caring for sick patients.

Filoviridae is a family of negative-sense, single-stranded RNA viruses that includes three genera: Ebolavirus, Marburgvirus, and Cuevavirus. These viruses are known to cause severe hemorrhagic fever in humans and nonhuman primates, with high fatality rates. The most well-known members of this family are Ebola virus and Marburg virus.

The virions of Filoviridae are filamentous, often having a "U," "6," or "hook" shape, and can be up to 14,000 nanometers in length. The genome of these viruses is non-segmented and contains seven genes that encode for structural proteins and enzymes necessary for replication.

Transmission of Filoviridae occurs through direct contact with infected bodily fluids or contaminated surfaces, and infection can result in a range of symptoms including fever, severe headache, muscle pain, weakness, fatigue, and hemorrhage. There are currently no approved vaccines or antiviral treatments for Filoviridae infections, although several are in development.

Marburg Virus Disease (MVD) is an acute and often fatal viral hemorrhagic fever illness caused by the Marburg virus, a member of the filovirus family. It's a highly infectious disease that can be transmitted from human to human through direct contact with infected bodily fluids, tissues, or indirectly through contaminated surfaces and materials.

The incubation period for MVD ranges from 2 to 21 days, after which symptoms such as fever, chills, headache, muscle aches, severe malaise, and progressive weakness appear. Around the fifth day of illness, a maculopapular rash may occur, followed by diarrhea, nausea, vomiting, abdominal pain, and non-bloody stools. In some cases, patients may develop severe bleeding disorders, shock, liver failure, and multi-organ dysfunction, which can lead to death in 24-48 hours.

Currently, there are no approved vaccines or antiviral treatments for MVD, but supportive care is crucial for managing the symptoms of the disease. Preventive measures such as avoiding contact with infected individuals and their bodily fluids, wearing protective clothing, and practicing good hygiene can help prevent the spread of the virus.

According to the World Health Organization (WHO), Marburgviruses are toxiviral hemorrhagic fever-causing agents that belong to the Filoviridae family, which also includes Ebolaviruses. These enveloped, non-segmented, negative-stranded RNA viruses cause a severe and often fatal illness in humans and non-human primates. The Marburg virus was initially discovered in 1967, after simultaneous outbreaks occurred in laboratories in Marburg and Frankfurt, Germany, and in Belgrade, Yugoslavia (now Serbia).

The virions of Marburgviruses are typically filamentous or U-shaped and measure approximately 80 nm in diameter. The genome consists of a single non-segmented, negative-sense RNA molecule that encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor protein (VP35), matrix protein (VP40), glycoprotein (GP), transcription activator protein (VP30), RNA-dependent RNA polymerase (L), and a small hydrophobic protein (sVP24 or VP80).

Marburgviruses are primarily transmitted to humans through contact with the bodily fluids of infected animals, such as bats and non-human primates. Human-to-human transmission can occur via direct contact with infected individuals' blood, secretions, organs, or other bodily fluids, as well as through contaminated surfaces and materials.

The incubation period for Marburg virus disease (MVD) typically ranges from 2 to 21 days. Initial symptoms include fever, chills, headache, muscle aches, and general malaise. As the disease progresses, patients may develop severe watery diarrhea, abdominal pain, nausea, vomiting, and unexplained bleeding or bruising. In fatal cases, MVD can cause multi-organ failure, shock, and death, often within 7 to 14 days after symptom onset.

Currently, there are no approved vaccines or antiviral treatments specifically for Marburg virus infections. However, supportive care, such as fluid replacement, electrolyte management, and treatment of secondary infections, can help improve outcomes for MVD patients. Preventive measures, including the use of personal protective equipment (PPE) and proper infection control practices, are crucial to reducing the risk of transmission during outbreaks.

Ebolavirus is a genus of viruses in the family Filoviridae, order Mononegavirales. It is named after the Ebola River in the Democratic Republic of Congo (formerly Zaire), where the virus was first identified in 1976. There are six species of Ebolavirus, four of which are known to cause disease in humans: Zaire ebolavirus, Sudan ebolavirus, Bundibugyo ebolavirus, and Tai Forest ebolavirus (formerly Cote d'Ivoire ebolavirus). The fifth species, Reston ebolavirus, is known to cause disease in non-human primates and pigs, but not in humans. The sixth and most recently identified species, Bombali ebolavirus, has not been associated with any human or animal diseases.

Ebolaviruses are enveloped, negative-sense, single-stranded RNA viruses that cause a severe and often fatal hemorrhagic fever in humans and non-human primates. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats of the Pteropodidae family are considered to be the natural host of Ebolavirus.

The symptoms of Ebolavirus disease (EVD) typically include fever, severe headache, muscle pain, weakness, fatigue, and sore throat, followed by vomiting, diarrhea, rash, impaired kidney and liver function, and in some cases, both internal and external bleeding. The case fatality rate of EVD is variable but has been historically high, ranging from 25% to 90% in past outbreaks depending on the species and the quality of medical care. There are no licensed specific treatments or vaccines available for EVD, although several promising candidates are currently under development.

Ebola Hemorrhagic Fever (EHF) is a severe, often fatal illness in humans. It is one of the five identified subtypes of the Ebolavirus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission.

The early symptoms include sudden onset of fever, fatigue, muscle pain, headache and sore throat. This is followed by vomiting, diarrhea, rash, symptoms of impaired kidney and liver function, and in some cases, both internal and external bleeding.

Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes.

The virus is introduced into the human population through close contact with the blood, secretions, organs or other bodily fluids of infected animals such as fruit bats, porcupines and non-human primates. Then it spreads in communities through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials contaminated with these fluids.

Healthcare workers have frequently been infected while treating patients with suspected or confirmed EVD due to a lack of adequate infection prevention and control measures.

There are currently no approved specific antiviral drugs or vaccines for Ebola. Several promising treatments and vaccine candidates are being evaluated.

Zeller H, Bouloy M (April 2000). "Infections by viruses of the families Bunyaviridae and Filoviridae". Rev Sci Tech. 19 (1): 79 ... there are no known symptoms of infection. There is a quick period of viraemia before seroconversion and the infection is ... However, if the animal is pregnant and not protected by antibodies from a previous infection, Cache Valley virus can be very ... After 45-50 days of gestation CVV infection is not expected to cause harmful effects. After 76 days the fetus has a functioning ...
"Methods for treating Filoviridae virus infections", published 5 May 2016, issued 8 August 2017, assigned to Gilead Sciences Inc ... "Methods for treating Filoviridae virus infections", published 1 November 2018, issued 9 April 2019, assigned to Gilead Sciences ... and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection ... The results found that remdesivir functioned well as an inhibitor of the infection. The study was published as a letter to the ...
A similar change in the current circulating strains of EBOV could greatly increase the infection and disease rates caused by ... Wikispecies has information related to Filoviridae. ICTV Report: Filoviridae "Filoviridae". NCBI Taxonomy Browser. 11266. " ... The name Filoviridae is derived from the Latin noun filum (alluding to the filamentous morphology of filovirions) and the ... The family Filoviridae is a virological taxon that was defined in 1982 and emended in 1991, 1998, 2000, 2005, 2010 and 2011. ...
A case of MARV infection occurred in 1980 in Kenya. A French man, who worked as an electrical engineer in a sugar factory in ... List of other Filoviridae outbreaks "Ebola Virus Disease & Marburg Virus Disease - Chapter 3 - 2018 Yellow Book , Travelers' ... Both men had been admitted to hospitals in June and survived their infections, which were proven to be due to MARV. A fourth, ... Most marburgvirus infections were repeatedly associated with people visiting natural caves or working in mines. In 2009, the ...
... filoviridae infections MeSH C02.782.580.250.400 - hemorrhagic fever, ebola MeSH C02.782.580.250.500 - marburg virus disease ... cardiovirus infections MeSH C02.782.687.207 - common cold MeSH C02.782.687.359 - enterovirus infections MeSH C02.782.687.359. ... deltaretrovirus infections MeSH C02.782.815.200.260 - enzootic bovine leukosis MeSH C02.782.815.200.470 - htlv-i infections ... avulavirus infections MeSH C02.782.580.600.080.600 - newcastle disease MeSH C02.782.580.600.400 - henipavirus infections MeSH ...
Most viral infections of humans and other animals have incubation periods during which the infection causes no signs or ... Several highly lethal viral pathogens are members of the Filoviridae. Filoviruses are filament-like viruses that cause viral ... The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... Smallpox infections have been eradicated. Vaccines are available to prevent over thirteen viral infections of humans, and more ...
The first infections occurred in laboratory workers who were conducting necropsies on imported African green monkeys. The ... List of epidemics List of Filoviridae outbreaks "Marburg Hemorrhagic Fever (Marburg HF) , CDC". www.cdc.gov. 25 February 2019. ... The ratio of primary to secondary infections was 21:3 in Marburg, 4:2 in Frankfurt, and 1:1 in Belgrade. Three cases of ... The monkeys were believed to have been infected in Uganda, although infection from other animals in storage in London was also ...
Some zoonotic infections are often "dead ends", in that after the initial outbreak the rate of subsequent infections subsides ... Several highly lethal viral pathogens are members of the Filoviridae. Filoviruses are filament-like viruses that cause viral ... References to influenza infections date from the late 15th and early 16th centuries, but infections almost certainly occurred ... a bacterial infection - is probably the most notorious. Except for smallpox and influenza, documented outbreaks of infections ...
Ebola virus infection was lethal to nearly all monkeys. However, most of the monkeys infected with Reston virus recovered in a ... Netesov, S. V.; Feldmann, H.; Jahrling, P. B.; Klenk, H. D.; Sanchez, A. (2000). "Family Filoviridae". In van Regenmortel, M. H ... Although the man was asymptomatic and the source of the infection is uncertain, this could represent the first case of pig-to- ... Following the test at the CDC campus in DeKalb County, two of the monkeys who had survived Reston virus infection were infected ...
Hence, NPC1 was shown to be critical to entry of this filovirus, because it mediates infection by binding directly to viral GP ... Netesov SV, Feldmann H, Jahrling PB, Klenk HD, Sanchez A (2000). "Family Filoviridae". In van Regenmortel MHV, Fauquet CM, ... Silencing its effect with siRNA prevented infection of Vero cells. TIM1 is expressed in tissues known to be seriously impacted ... A further study has also presented evidence that NPC1 is the critical receptor mediating Ebola infection via its direct binding ...
Tai Forest ebolavirus has been seen in a single human infection due to contact with chimpanzees from the Tai Forest in Côte ... The species Taï Forest ebolavirus (/tɑːˈiː/) is a virological taxon included in the genus Ebolavirus, family Filoviridae, order ...
If the basic reproduction number is less than 1, the infection dies out; if it is greater than 1, the infection continues to ... "Filoviridae". Centers for Disease Control and Prevention (CDC). Retrieved 5 August 2018. "Filoviridae , Viral Hemorrhagic ... 22 November 2018). "Infection Rates and Risk Factors for Infection Among Health Workers During Ebola and Marburg Virus ... On 12 June, the WHO reported that the 5-year-old patient had died, while 2 more cases of Ebola infection within the same family ...
This approach has provided minimum ages ranging from 30 to 93 million years for the Parvoviridae, Filoviridae, Bornaviridae and ... For example, some protect against infection with related viruses. In some mammal groups, including higher primates, retroviral ...
After infection, endothelial cells (cells lining the inside of blood vessels), liver cells, and several types of immune cells ... December 2010). "Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and ... Following infection, immune cells carry the virus to nearby lymph nodes where further reproduction of the virus takes place. ... The Ebola virus may be able to persist for more than three months in the semen after recovery, which could lead to infections ...
Current infections have not run their course, and the estimate may be poor if reporting is biased towards severe cases. The ... "Filoviridae: Current Taxonomy (2015)". International Committee on Taxonomy of Viruses. 2015. Archived from the original on 10 ... Emond, R. T. D.; Evans, Brandon; Bowen, E. T. W.; Lloyd, G. (1977). "A case of Ebola virus infection". British Medical Journal ... RESTV has caused subclinical infections in humans, producing an antibody response but no visual symptoms or disease state ...
Emond, R T; Evans, B; Bowen, E T; Lloyd, G (27 August 1977). "A case of Ebola virus infection". British Medical Journal. 2 ( ... Beer, B.; Kurth, R.; Bukreyev, A. (1999). "Characteristics of Filoviridae: Marburg and Ebola viruses". Die Naturwissenschaften ... Mole, Beth (2023-02-04). "Freak infection with an eradicated form of polio shows virus' craftiness". Ars Technica. Condé Nast. ... Siengsanan-Lamont, Jarunee; Blacksell, Stuart D. (2018). "A Review of Laboratory-Acquired Infections in the Asia-Pacific: ...
The cases were later confirmed as Marburg virus infection and on 21 March 2023. Though there is an ongoing outbreak of marburg ... 2023 Marburg virus disease outbreak in Equatorial Guinea List of other Filoviridae outbreaks "Tanzania confirms first-ever ...
People who were vaccinated were followed up for 84 days to assess whether they were protected from infection and to monitor any ... Zaire ebolavirus, which was identified in this outbreak, is included in genus Ebolavirus, family Filoviridae, The virus was ... Post-Ebola virus syndrome affects those who have survived EVD infection; the resulting signs and symptoms can include muscle ... Nebehay, Stephanie (24 May 2018). "Infection alert after dying Ebola patients taken to Congo prayer…". Reuters. Retrieved 24 ...
"Filoviridae". ViralZone. SIB Swiss Institute of Bioinformatics. Archived from the original on 2015-10-04. Retrieved 2015-10-03 ... A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... "Babies Born with CMV (Congenital CMV Infection)". Centers for Disease Control and Prevention. April 13, 2017. Retrieved June 17 ... Page 273 in: Lennette's Laboratory Diagnosis of Viral Infections (Fourth ed.). CRC Press. 2010. ISBN 978-1420084962. Murillo A ...
Filoviridae) Ebola virus (Filoviridae) Influenza (Orthomyxoviridae) Measles (Paramyxoviridae) Mumps virus (Paramyxoviridae) ... which often aims to prevent viral infections. In modern history, numerous disease outbreaks have been caused by RdRp-encoding ...
It then injects its DNA or RNA into the host to initiate infection. In animal cells these viruses get into the cell through the ... Examples in this class include the families Orthomyxoviridae, Paramyxoviridae, Bunyaviridae, Filoviridae, and Rhabdoviridae ( ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ... The Effects of Viral Infections and Viral Insulins on Host Metabolism". Annual Review of Virology. 8 (1): 373-391. doi:10.1146/ ...
Filoviridae) Ebola virus (Filoviridae) Influenza (Orthomyxoviridae) Measles (Paramyxoviridae) Mumps virus (Paramyxoviridae) ... Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X (2017). "Hantavirus infection: a global zoonotic challenge". Virol Sin. 32 (1): ... Borkenhagen LK, Salman MD, Ma MJ, Gray GC (November 2019). "Animal influenza virus infections in humans: A commentary". Int J ... Avsic-Zupanc T, Saksida A, Korva M (April 2019). "Hantavirus infections". Clin Microbiol Infect. 21S: e6-e16. doi:10.1111/1469- ...
After the first infection, macrophages display antibodies on their cell membranes specific to the dengue virus. By attaching to ... VHFs may be caused by five distinct families of RNA viruses: the families Filoviridae, Flaviviridae, Rhabdoviridae, and several ... Post-exposure prophylactic (preventive) ribavirin may be effective for some bunyavirus and arenavirus infections. VHF isolation ... Dengue fever becomes more virulent during a second infection by means of antibody-dependent enhancement. ...
Aditi; Shariff, M. (2019). "Nipah virus infection: A review". Epidemiology and Infection. 147: e95. doi:10.1017/ ... Filoviridae is a family of virus containing two genera associated with bats: Marburgvirus and Ebolavirus, which contain the ... In late 2012, a vaccine was released to prevent infection in horses. Vaccine uptake has been low, with an estimated 11-17% of ... Bats' immune systems may have evolved to be more tolerant of stressors such as viral infections compared to other mammals. The ...
A virus of the family Filoviridae is a member of the genus Ebolavirus if its genome has several gene overlaps its fourth gene ( ... Researchers have found evidence of Ebola infection in three species of fruit bat. The bats show no symptoms of the disease, ... is a virological taxon included in the family Filoviridae (filament-shaped viruses), order Mononegavirales. The members of this ...
... (MARV) is a hemorrhagic fever virus of the Filoviridae family of viruses and a member of the species Marburg ... Furthermore, NPC1 was shown to be critical to filovirus entry because it mediates infection by binding directly to the viral ... In one of the original studies, a small molecule was shown to inhibit Ebola virus infection by preventing the virus ... Niemann-Pick C1 (NPC1) cholesterol transporter protein appears to be essential for infection with both Ebola and Marburg virus ...
Filoviridae) Ebola virus (Filoviridae) Influenza (Orthomyxoviridae) Measles (Paramyxoviridae) Mumps virus (Paramyxoviridae) ... Purified RNA of a positive-sense virus can directly cause infection though it may be less infectious than the whole virus ... Kondo H, Chiba S, Toyoda K, Suzuki N (January 2013). "Evidence for negative-strand RNA virus infection in fungi". Virology. 435 ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans. Classification is based principally ...
The sub-type Zaire ebolavirus has been confirmed in the current outbreak, from the family Filoviridae. It is a single stranded ... is a rare and deadly disease caused by infection with one of the Ebola virus species. Ebola can cause disease in humans and ... "Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations ...
Health Canada reports that world-wide until 1999 there were recorded over 5,000 cases of accidental laboratory infections and ... A standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae". ... "Members: The Doherty Institute for Infection and Immunity". Global Virus Network. May 2013. Archived from the original on 20 ... Journal of Infection and Public Health. 9 (3): 236-239. doi:10.1016/j.jiph.2016.04.007. PMC 7102798. PMID 27118215. Racaniello ...
The initial infection is believed to occur after an Ebola virus is transmitted to a human by contact with an infected animal's ... "Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations ... Secondary infections of medical workers occurred in the United States and Spain. In addition, isolated cases were recorded in ... By November 2014, the rate of new infections in Liberia appeared to be declining and the state of emergency was lifted. The ...
Zeller H, Bouloy M (April 2000). "Infections by viruses of the families Bunyaviridae and Filoviridae". Rev Sci Tech. 19 (1): 79 ... there are no known symptoms of infection. There is a quick period of viraemia before seroconversion and the infection is ... However, if the animal is pregnant and not protected by antibodies from a previous infection, Cache Valley virus can be very ... After 45-50 days of gestation CVV infection is not expected to cause harmful effects. After 76 days the fetus has a functioning ...
Categories: Filoviridae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Ebola is caused by infection with a virus of the family Filoviridae, genus Ebolavirus. There are five identified Ebola virus ... Ebola Virus Infection Associated with Transmission from Survivors Saskia Den Boon et al. Volume 25, Number 2-February 2019 ... Vectorborne Infections, Mali David Safronetz et al. Volume 22, Number 2-February 2016 Responding to Ebola through Visual Poetry ... Secondary Infections with Ebola Virus in Rural Communities, Liberia and Guinea, 2014-2015 Kim A. Lindblade et al. Volume 22, ...
The family Filoviridae resides in the order Mononegavirales and contains the largest genome within the order. This family ... encoded search term (Ebola Virus Infection) and Ebola Virus Infection What to Read Next on Medscape ... Ebola Virus Infection. Updated: Aug 08, 2023 * Author: John W King, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD ... Among infection survivors, only males had been shown to transmit the virus, via semen, in which the virus can persist for up to ...
Filoviridae Infections, Hepatitis, Acquired Immunodeficiency Syndrome, Rabies ... Respiratory Tract Infections, Hypertension, Tuberculosis, Leprosy, ATENÇÃO BÁSICA ...
Filoviridae), Lassa virus (Arenaviridae), Crimean-Congo hemorrhagic fever and Rift Valley Fever virus (Bunyaviridae), and ... Burn wound infections and colonization, as well as bloodstream infections, caused by multidrug-resistant P. aeruginosa 361, A. ... Infections of home care providers, that could pose a risk to home care patients include infections transmitted by the airborne ... alert icon Interim Measles Infection Control [July 2019]. See Interim Infection Prevention and Control Recommendations for ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
FILOVIRUS INFECTIONS. FILOVIRIDAE INFECTIONS. C10 - NERVOUS SYSTEM DISEASES. BRAIN DISEASES, METABOLIC, ACQUIRED. BRAIN ...
Mononegavirales Infections [C02.782.580]. *Filoviridae Infections [C02.782.580.250]. *Hemorrhagic Fever, Ebola [C02.782.580.250 ...
... and Filovirus Infections - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical ... The Filoviridae consists of 2 genera: Ebolavirus (consisting of 5 species) and Marburgvirus (consisting of 2 species). The ... Some infections (eg, West Nile virus infection West Nile Virus West Nile virus is a flavivirus that is now the primary cause of ... Zika virus infection is typically... read more , and chikungunya disease Chikungunya Disease Chikungunya disease is transmitted ...
These febrile diseases result from infection by viruses from 4 viral families: Arenaviridae, Bunyaviridae, Filoviridae, and ... These febrile diseases result from infection by viruses from 4 viral families: Arenaviridae, Bunyaviridae, Filoviridae, and ... Random cases of infection occur as a result of the importation of viruses by travelers or the importation of scientific ... Recognition of viral infection by the innate immune system occurs through the cytoplasmic recognition of cellular receptors of ...
The patent states that Remdesivir, is useful for treating "Filoviridae virus infection" to which family the novel coronavirus ...
The patent stated that it is useful for treating Filoviridae virus infection and the coronavirus belongs to the same family of ...
Marburg Filoviridae virus infection. *Yellow fever. *Ebola. *Lassa fever. *Hantavirus hemorrhagic fever with renal syndrome ... Asymptomatic and mild infections occur often, but the mortality rate of the hemorrhagic form is 20%-50%.. At present, no ...
Currently, no licensed therapies exist to treat filovirus infections, which cause up to 90% mortality in human cases. To ... Marburg virus (MARV) and Ebola virus (EBOV), members of the family Filoviridae, represent a significant challenge to global ... Currently, no licensed therapies exist to treat filovirus infections, which cause up to 90% mortality in human cases. To ... Marburg virus (MARV) and Ebola virus (EBOV), members of the family Filoviridae, represent a significant challenge to global ...
Ebola virus is part of the Filoviridae family of viruses. The reservoir of the virus is most likely bats and the virus can then ... Preventing Ebola infection through a vaccine is now a major global research focus and researchers from the Scripps Research ... At only 3 months post infection, 3% of the donor IgG antibodies were specific to the Ebola envelope glycoprotein (GP) and bound ... Flynn Webinar: Immune features associated natural infection. *Flynn Webinar: What immune cells play a role in protection ...

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