Gigantism
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Growth Hormone-Secreting Pituitary Adenoma
Dinosaurs
Acromegaly
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Bermuda
A British colony in the western North Atlantic Ocean about 640 miles east southeast of Cape Hatteras, North Carolina. It comprises a group of about 300 islands of which only about 20 are inhabited. It is called also the Bermuda Islands or the Bermudas. It was named for the Spanish explorer Juan Bermudez who visited the islands in 1515. (From Webster's New Geographical Dictionary, 1988, p140 & Room, Brewer's Dictionary of Names, 1992, p61)
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Reptiles
Adenoma, Acidophil
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Arthropods
Growth in Sotos syndrome. (1/60)
Although there are several reports on infant and childhood growth in patients with Sotos syndrome, there is little information on the final height achieved and puberty. Growth data on 40 patients (20 female and 20 male) aged 2-31 years were collected. These showed that patients with Sotos syndrome are excessively tall at birth, during infancy, and during childhood. Disproportionately long limbs constitute much of the increase in stature. However, the combination of advanced bone age and early onset of menarche led to a mean (SD) final height of 172.9 (5.7) cm in women. This is within the normal range for the population. Most of the men also attained a final height (mean, 184.3 cm; SD, 6.0) within the normal range, although exceptions were more likely in men than in women. Therefore, these results show that most patients with Sotos syndrome do not require intervention to limit their adult height. (+info)Myocardial infarction with Moyamoya disease and pituitary gigantism in a young female patient. (2/60)
Myocardial infarction is very rare in young female patients with systemic vascular disorders. Moyamoya disease is a cerebrovascular disease associated with an abnormal vascular network. This report presents a 19-year-old female patient who suffered from chest pain and exertional dyspnea for 2 months prior to admission. She had a history of Moyamoya disease and pituitary gigantism since childhood. Her ejection fraction on echocardiogram was 20% and a perfusion defect with partial reversibility in the anterior wall was demonstrated on stress single photon emission computed tomography (SPECT). Diagnostic coronary angiogram revealed critical stenosis in the middle left anterior descending artery, which was treated by coronary stenting. Her subjective symptoms were relieved and the perfusion defect seen on SPECT decreased after coronary intervention. (+info)The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. (3/60)
Rearrangements of the HMGI-C gene have frequently been detected in human benign tumors of mesenchymal origin, including lipomas. The HMGI-C protein has three AT-hook domains and an acidic COOH-terminal tail. The HMGI-C modifications consist in the loss of the C-tail and the fusion with ectopic sequences. Recent results show that the loss of the COOH-terminal region, rather than the acquisition of new sequences, is sufficient to confer to HMGI-C the ability to transform NIH3T3 cells. Therefore, transgenic mice carrying a HMGI-C construct (HMGI-C/T), containing only the three AT-hook domains, were generated. The HMGI-C/T mice showed a giant phenotype, together with a predominantly abdominal/pelvic lipomatosis, suggesting a pivotal role of the HMGI-C truncation in the generation of human lipomas. (+info)Evidence for growth hormone (GH) autoregulation in pituitary somatotrophs in GH antagonist-transgenic mice and GH receptor-deficient mice. (4/60)
Growth hormone (GH) modulates the hypothalamic release of somatostatin and GH-releasing hormone; however, there has been no evidence of GH autoregulation on the pituitary somatotroph. To determine the effects of GH on its own regulation, we examined the pituitaries of giant transgenic mice expressing a GH agonist (E117L), dwarf transgenic mice expressing a GH antagonist (G119K), and dwarf mice devoid of the GH receptor/binding protein (GHR/BP). In the E117L transgenic mice, the number and distribution of pituitary GH-immunoreactive cells were unchanged from nontransgenic littermate controls; an ultrastructural examination revealed typical, densely granulated somatotrophs. In contrast, the pituitaries of the G119K mice contained both moderately granulated somatotrophs and a sparsely granulated (SG) population with well-developed synthetic organelles and a distinct juxtanuclear globular GH-staining pattern. GHR/BP-deficient mice exhibited a marked reduction in the intensity of cytoplasmic GH immunoreactivity; however, prominent GH staining in the juxtanuclear Golgi was seen. GH-immunoreactive cells were increased in number, and the reticulin network pattern was distorted; stains for proliferating cell nuclear antigen confirmed mild hyperplasia. Electron microscopy showed that the somatotrophs were hyperactive SG cells with prominent endoplasmic reticulum membranes, large Golgi complexes, and numerous mitochondria. These findings are consistent with synthetic and secretory hyperactivity in pituitary somatotrophs due to the reduced GH feedback regulation. The changes are most striking in animals that are devoid of GHR/BP and less marked in animals expressing a GH antagonist; both models had reduced insulin-like growth factor-I levels, but the more dramatic change in the GHR/BP animals can be explained by abrogated GH signaling. This represents the first evidence of direct GH feedback inhibition on pituitary somatotrophs, which may have implications for the use of GH analogs in different clinical settings. (+info)Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. (5/60)
Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked syndrome characterized by pre- and postnatal overgrowth (gigantism), which clinically resembles the autosomal Beckwith-Wiedemann syndrome (BWS). Deletions and translocations involving the glypican-3 gene ( GPC3 ) have been shown to be associated with SGBS. Occasionally, these deletions also include the glypican-4 gene ( GPC4 ). Glypicans are heparan sulfate proteoglycans which have a role in the control of cell growth and cell division. We have examined the mutational status of the GPC3 and GPC4 genes in one patient with Perlman syndrome, three patients with overgrowth without syndrome diagnosis, ten unrelated SGBS-patients and 11 BWS patients. We identified one SGBS patient with a deletion of a GPC3 exon. Six SGBS patients showed point mutations in GPC3. One frameshift, three nonsense, and one splice mutation predict a loss-of-function of the glypican-3 protein. One missense mutation, W296R, changes an amino acid that is conserved in all glypicans identified so far. A GPC3 protein that reproduces this mutation is poorly processed and fails to increase the cell surface expression of heparan sulfate, suggesting that this missense mutation is also a loss-of-function mutation. In three SGBS patients and in all non-SGBS patients, no mutations could be identified. We found three single nucleotide polymorphisms in the GPC4 gene but no evidence for loss-of-function mutations in GPC4 associated with SGBS. (+info)Sotos syndrome (cerebral gigantism): analysis of 8 cases. (6/60)
Sotos syndrome or cerebral gigantism is characterized by macrocephaly, overgrowth, mental retardation and central nervous system abnormalities. Congenital heart defects may be present. We report 8 patients with this syndrome and relate their clinical features, neuroimaging and echocardiographic findings. (+info)Comparative analysis of vertebrate dystrophin loci indicate intron gigantism as a common feature. (7/60)
The human DMD gene is the largest known to date, spanning > 2000 kb on the X chromosome. The gene size is mainly accounted for by huge intronic regions. We sequenced 190 kb of Fugu rubripes (pufferfish) genomic DNA corresponding to the complete dystrophin gene (FrDMD) and provide the first report of gene structure and sequence comparison among dystrophin genomic sequences from different vertebrate organisms. Almost all intron positions and phases are conserved between FrDMD and its mammalian counterparts, and the predicted protein product of the Fugu gene displays 55% identity and 71% similarity to human dystrophin. In analogy to the human gene, FrDMD presents several-fold longer than average intronic regions. Analysis of intron sequences of the human and murine genes revealed that they are extremely conserved in size and that a similar fraction of total intron length is represented by repetitive elements; moreover, our data indicate that intron expansion through repeat accumulation in the two orthologs is the result of independent insertional events. The hypothesis that intron length might be functionally relevant to the DMD gene regulation is proposed and substantiated by the finding that dystrophin intron gigantism is common to the three vertebrate genes. (+info)Cerebral gigantism with West syndrome. (8/60)
A case of cerebral gigantism (Sotos syndrome) with West syndrome in a one-year-old male child is reported. The case had a large stature, typical facies and neurodevelopmental delay along with infantile spasms, which were refractory to treatment with valproate and clonazepam. (+info)Gigantism is a rare hormonal disorder characterized by excessive growth and height acquisition due to overproduction of growth hormone before epiphyseal plate closure during childhood.
Gigantism is a rare medical condition characterized by excessive growth and height significantly above average. This occurs due to an overproduction of growth hormone (GH), also known as somatotropin, during the growth phase in childhood. The pituitary gland, a small gland located at the base of the brain, is responsible for producing this hormone.
In gigantism, the pituitary gland releases too much GH, leading to abnormal bone and tissue growth. This condition is different from acromegaly, which is characterized by excessive GH production in adulthood after the growth phase has ended. In both cases, the excess GH can lead to various health complications, including cardiovascular disease, diabetes, hypertension, and joint problems.
Gigantism is typically caused by a benign tumor called a pituitary adenoma that presses against and stimulates the production of GH from the anterior pituitary gland. Treatment usually involves surgical removal of the tumor or medication to control GH levels, depending on the severity and progression of the condition. Early diagnosis and treatment are crucial for managing the symptoms and preventing long-term health complications associated with gigantism.
"Body size is a broad term referring to the overall dimension or mass of an individual's body, typically encompassing parameters such as height, weight, and girth measurements."
"Body size" is a general term that refers to the overall physical dimensions and proportions of an individual's body. It can encompass various measurements, including height, weight, waist circumference, hip circumference, blood pressure, and other anthropometric measures.
In medical and public health contexts, body size is often used to assess health status, risk factors for chronic diseases, and overall well-being. For example, a high body mass index (BMI) may indicate excess body fat and increase the risk of conditions such as diabetes, hypertension, and cardiovascular disease. Similarly, a large waist circumference or high blood pressure may also be indicators of increased health risks.
It's important to note that body size is just one aspect of health and should not be used as the sole indicator of an individual's overall well-being. A holistic approach to health that considers multiple factors, including diet, physical activity, mental health, and social determinants of health, is essential for promoting optimal health outcomes.
A Growth Hormone-Secreting Pituitary Adenoma is a type of benign pituitary tumor that secretes excessive amounts of growth hormone, leading to acromegaly in adults or gigantism in children.
A Growth Hormone-Secreting Pituitary Adenoma (GH-secreting pituitary adenoma, or GHoma) is a type of benign tumor that develops in the pituitary gland and results in excessive production of growth hormone (GH). This leads to a condition known as acromegaly if it occurs in adults, or gigantism if it occurs in children before the closure of the growth plates.
Symptoms of GH-secreting pituitary adenoma may include:
1. Coarsening of facial features
2. Enlargement of hands and feet
3. Deepened voice due to thickening of vocal cords
4. Increased sweating and body odor
5. Joint pain and stiffness
6. Sleep apnea
7. Fatigue, weakness, or muscle wasting
8. Headaches
9. Vision problems
10. Irregular menstrual periods in women
11. Erectile dysfunction in men
Diagnosis typically involves measuring the levels of GH and insulin-like growth factor 1 (IGF-1) in the blood, along with imaging tests like MRI or CT scans to locate and characterize the tumor. Treatment options include surgical removal of the tumor, radiation therapy, and medication to control GH production. Regular follow-ups are necessary to monitor for potential recurrence.
**Medical Definition:** Dinosaurs are a group of extinct terrestrial reptiles that existed for over 160 million years, characterized by their upright posture and diverse adaptations, with species ranging from the colossal sauropods to agile theropods like *Velociraptor* and *Tyrannosaurus rex*.
Dinosaurs are a group of reptiles that were the dominant terrestrial vertebrates for over 160 million years, from the late Triassic period until the end of the Cretaceous period. They first appeared approximately 230 million years ago and went extinct around 65 million years ago.
Dinosaurs are characterized by their upright stance, with legs positioned directly under their bodies, and a wide range of body sizes and shapes. Some dinosaurs were enormous, such as the long-necked sauropods that could reach lengths of over 100 feet, while others were small and agile.
Dinosaurs are classified into two main groups: the saurischians (lizard-hipped) and the ornithischians (bird-hipped). The saurischians include both the large carnivorous theropods, such as Tyrannosaurus rex, and the long-necked sauropods. The ornithischians were primarily herbivores and included a diverse array of species, such as the armored ankylosaurs and the horned ceratopsians.
Despite their extinction, dinosaurs have left a lasting impact on our planet and continue to be a source of fascination for people of all ages. The study of dinosaurs, known as paleontology, has shed light on many aspects of Earth's history and the evolution of life on our planet.
Acromegaly is a chronic endocrine disorder characterized by the excessive growth hormone production, typically from a pituitary adenoma, leading to progressive enlargement of bones, particularly in the face, hands, and feet, along with various systemic manifestations if left untreated.
Acromegaly is a rare hormonal disorder that typically occurs in middle-aged adults. It results from the pituitary gland producing too much growth hormone (GH) during adulthood. The excessive production of GH leads to abnormal growth of body tissues, particularly in the hands, feet, and face.
The term "acromegaly" is derived from two Greek words: "akros," meaning extremities, and "megaly," meaning enlargement. In most cases, acromegaly is caused by a benign tumor (adenoma) of the pituitary gland, which results in overproduction of GH.
Common symptoms include enlarged hands and feet, coarse facial features, deepened voice, joint pain, and sweating. If left untreated, acromegaly can lead to serious complications such as diabetes, hypertension, heart disease, and arthritis. Treatment usually involves surgical removal of the tumor, radiation therapy, or medication to control GH production.
I'm sorry for any confusion, but "Bermuda" is not a term with a widely accepted medical definition in the field of medicine or healthcare. It appears to be a geographical location and does not have specific relevance to medical terminology.
I'm not aware of any medical definition for the term "Bermuda." The term "Bermuda" is typically used to refer to a group of islands located in the North Atlantic Ocean, or it can be used more generally to refer to something related to those islands. It is not a term that is commonly used in a medical context. If you have encountered this term in a medical context and are seeking clarification, I would recommend checking the source again or consulting with a healthcare professional for further information.
Pituitary neoplasms are abnormal growths (tumors or tumor-like lesions) that develop within the pituitary gland, which can be benign or malignant, secretory or non-secretory, and may result in various hormonal imbalances and neurological symptoms due to their location at the base of the brain.
Pituitary neoplasms refer to abnormal growths or tumors in the pituitary gland, a small endocrine gland located at the base of the brain. These neoplasms can be benign (non-cancerous) or malignant (cancerous), with most being benign. They can vary in size and may cause various symptoms depending on their location, size, and hormonal activity.
Pituitary neoplasms can produce and secrete excess hormones, leading to a variety of endocrine disorders such as Cushing's disease (caused by excessive ACTH production), acromegaly (caused by excessive GH production), or prolactinoma (caused by excessive PRL production). They can also cause local compression symptoms due to their size, leading to headaches, vision problems, and cranial nerve palsies.
The exact causes of pituitary neoplasms are not fully understood, but genetic factors, radiation exposure, and certain inherited conditions may increase the risk of developing these tumors. Treatment options for pituitary neoplasms include surgical removal, radiation therapy, and medical management with drugs that can help control hormonal imbalances.
Reptiles are a group of air-breathing, cold-blooded vertebrates characterized by the presence of scales on their skin, laying eggs on land, and having a three-chambered heart, including snakes, lizards, turtles, crocodiles, and extinct groups like dinosaurs.
I'm sorry for any confusion, but "Reptiles" is not a medical term. It is a term used in biology to describe a class of cold-blooded, scaly-skinned animals that include snakes, lizards, alligators, crocodiles, turtles, and tortoises. They are characterized by having lungs for breathing, laying eggs on land, and having a three-chambered heart. If you have any medical questions or terms, I'd be happy to help clarify those!
An adenoma, acidophil is a specific type of benign tumor that develops from the acidophilic cells (also known as somatotrophs) of the anterior pituitary gland, which can lead to excessive production of growth hormone, resulting in acromegaly or gigantism if presented in children.
An adenoma is a benign tumor that forms in glandular tissue. When referring to "acidophil," it describes the appearance of the cells under a microscope. Acidophils are cells that take up acidic dyes, giving them a distinct appearance. In the context of an adenoma, an acidophil adenoma would be a benign tumor composed of acidophil cells.
Acidophil adenomas are most commonly found in the pituitary gland and are also known as lactotroph or mammosomatotroph adenomas. These tumors can produce and release prolactin, growth hormone, or both, leading to various endocrine disorders such as hyperprolactinemia, acromegaly, or gigantism. Treatment options typically include surgical removal of the tumor or medical management with dopamine agonists or somatostatin analogs.
Arthropods are invertebrate animals characterized by a segmented body, jointed appendages, and an exoskeleton made of chitin, which together form the phylum Arthropoda, including insects, arachnids, crustaceans, and myriapods.
Arthropods are a phylum of animals characterized by the presence of a segmented body, a pair of jointed appendages on each segment, and a tough exoskeleton made of chitin. This phylum includes insects, arachnids (spiders, scorpions, mites), crustaceans (crabs, lobsters, shrimp), and myriapods (centipedes, millipedes). They are the largest group of animals on Earth, making up more than 80% of all described species. Arthropods can be found in nearly every habitat, from the deep sea to mountaintops, and play important roles in ecosystems as decomposers, pollinators, and predators.
Gigantism - Wikipedia
Gigantism is characterized by an excess of growth hormone (GH). The excess of growth hormone that brings about gigantism is ... 2.95 MB) Gigantism Clinical Trials from U.S. National Institutes of Health Gigantism information from U.S. National Library of ... Finding a specific genetic cause for gigantism has proven to be difficult. Gigantism is the primary example of growth hormone ... "Gigantism: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 27 April 2017. "Gigantism and Acromegaly: Practice ...
Gigantism: MedlinePlus Medical Encyclopedia
Gigantism is abnormal growth due to an excess of growth hormone (GH) during childhood. ... Gigantism is abnormal growth due to an excess of growth hormone (GH) during childhood. ... Gigantism is very rare. The most common cause of too much GH release is a noncancerous (benign) tumor of the pituitary gland. ... Gigantism cannot be prevented. Early treatment may prevent the disease from getting worse and help avoid complications. ...
Gigantism and Acromegaly: Practice Essentials, Background, Pathophysiology and Etiology
Gigantism refers to abnormally high linear growth due to excessive action of insulinlike growth factor I (IGF-I) while the ... Gigantism. Gigantism is a nonspecific term that refers to any standing height more than 2 standard deviations above the mean ... encoded search term (Gigantism and Acromegaly) and Gigantism and Acromegaly What to Read Next on Medscape ... Gigantism and Acromegaly. Updated: Jun 09, 2020 * Author: Robert A Schwartz, MD, MPH; Chief Editor: Sasigarn A Bowden, MD, FAAP ...
And Then There Was One: Imperial Gigantism and the Decline of Planet Earth | Truthout
Cerebral gigantism (Sotos syndrome). Compiled data of 22 cases. Analysis of clinical features, growth and plasma somatomedin
Dwyer to discuss Polar Gigantism in Antarctic Sea Spiders | PolarTREC
Discovery of the Largest Orbweaving Spider Species: The Evolution of Gigantism in Nephila | PLOS ONE
Background More than 41,000 spider species are known with about 400-500 added each year, but for some well-known groups, such as the giant golden orbweavers, Nephila, the last valid described species dates from the 19th century. Nephila are renowned for being the largest web-spinning spiders, making the largest orb webs, and are model organisms for the study of extreme sexual size dimorphism (SSD) and sexual biology. Here, we report on the discovery of a new, giant Nephila species from Africa and Madagascar, and review size evolution and SSD in Nephilidae. Methodology We formally describe N. komaci sp. nov., the largest web spinning species known, and place the species in phylogenetic context to reconstruct the evolution of mean size (via squared change parsimony). We then test female and male mean size correlation using phylogenetically independent contrasts, and simulate nephilid body size evolution using Monte Carlo statistics. Conclusions Nephila females increased in size almost monotonically to
Gigantism and Acromegaly: Practice Essentials, Background, Pathophysiology and Etiology
Gigantism refers to abnormally high linear growth due to excessive action of insulinlike growth factor I (IGF-I) while the ... Gigantism. Gigantism is a nonspecific term that refers to any standing height more than 2 standard deviations above the mean ... encoded search term (Gigantism and Acromegaly) and Gigantism and Acromegaly What to Read Next on Medscape ... Gigantism and Acromegaly. Updated: Jun 09, 2020 * Author: Robert A Schwartz, MD, MPH; Chief Editor: Sasigarn A Bowden, MD, FAAP ...
Global Acromegaly and Gigantism Drugs Market 2018-2022 Market
Acromegaly and gigantism drugs industry growth will also be impacted by the demand for non-surgical options and the popularity ... Acromegaly and gigantism drugs market analysis indicates growth will be driven by the presence of a strong pipeline. ... Global acromegaly and gigantism drugs market size will grow by USD 189.78 million during 2018-2022, at a CAGR of 3%. The ... Top acromegaly and gigantism drugs companies covered in this market research report. The acromegaly and gigantism drugs market ...
Growth hormone pituitary microadenoma - gigantism | Radiology Case | Radiopaedia.org
In the skeletally immature, in whom long bones can continue to grow, gigantism is the result. ... Gaillard F, Growth hormone pituitary microadenoma - gigantism. Case study, Radiopaedia.org (Accessed on 30 Sep 2023) https:// ... ":"growth-hormone-pituitary-microadenoma-gigantism","modality":"X-ray","series":[{"id":10001000,"content_type":"image/jpeg"," ... ":"growth-hormone-pituitary-microadenoma-gigantism","modality":"CT","series":[{"id":9999535,"content_type":"image/jpeg","frames ...
Cook Strait Giant Weta female climbing onto Bryce's hand (Deinacrida rugosa, Stenopelmatidae). Endemic endangered New Zealand...
Cook Strait Giant Weta male (Deinacrida rugosa, Stenopelmatidae). Endemic endangered New Zealand insect. Wetapunga. Island...
Into the Ground: Cataloging Latent Gigantism | Tower to TowerGigantism in Architecture and Digital Culture | Books Gateway |...
Quick Facts: Gigantism and Acromegaly - MSD Manual Consumer Version
Gigantism and Acromegaly - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer ... What are gigantism and acromegaly? Gigantism and acromegaly are patterns of abnormal growth caused by having too much growth ... How can doctors tell if a person has gigantism or acromegaly? Its usually easy to see when children are growing too much. But ... Doctors treat gigantism and acromegaly with surgery and medicines to lower growth hormone levels ...
These Student Designed Images Will Blow Your Mind With Their Gigantism
Gigantism | Profiles RNS
"Gigantism" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Gigantism" by people in this website by year, and whether " ... Below are the most recent publications written about "Gigantism" by people in Profiles. ...
On Gigantism | Protesilaos Stavrou
Gigantism is about establishing/reinforcing a hierarchy that controls every aspect of life within its field of application. We ... The common denominator is gigantism.. Gigantism detests autonomy and autarky. We may not live in a modern incarnation of the ... We can find gigantism as a fully realised ambition in the empires of yore as well as everywhere in our world. The Romans at the ... This is gigantism: the belief in the inherent value of aggrandising the scale of operations while concentrating control. ...
Gigantism and Acromegaly Differential Diagnoses
Gigantism refers to abnormally high linear growth due to excessive action of insulinlike growth factor I (IGF-I) while the ... encoded search term (Gigantism and Acromegaly) and Gigantism and Acromegaly What to Read Next on Medscape ... Gigantism and Acromegaly Differential Diagnoses. Updated: Jan 06, 2015 * Author: Alicia Diaz-Thomas, MD, MPH; Chief Editor: ... Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. N Engl J Med. 2014 Dec 18. 371(25):2363-74. [QxMD ...
Hand⎪Macrodactyly (local gigantism) - Orthohub
Gigantism Archives - Natural Health News
Hyper secretion of which hormone causes gigantism?
Gigantism occurs when growth hormone hypersecretion occurs before the fusion of the long bone epiphysis and is characterized by ... Detailed explanation-1: -Acromegaly and gigantism are disorders of growth hormone hypersecretion. The most common cause is a ... Detailed explanation-2: -Gigantism is abnormal growth due to an excess of growth hormone (GH) during childhood. ...
Difference Between Acromegaly and Gigantism (With Table)
Gigantism occurs in children, leading to unusual height. ... Acromegaly and gigantism are conditions caused by excessive ... While Gigantism affects people below the age of 20.. *In acromegaly, the height of a person might be average. In gigantism, the ... What is Gigantism?. Gigantism also happens due to the overproduction of growth hormones by the pituitary gland. However, unlike ... Acromegaly vs Gigantism. The main difference between Acromegaly and Gigantism is that Acromegaly happens when the pituitary ...
10 Medical Conditions Once Found in Sideshows | HowStuffWorks
5: Gigantism ". " Gigantism sometimes causes people to grow to extreme heights. © Historical/CORBIS ... Gigantism can be a symptom of other conditions, but by and large its caused by adenoma. Thats a tumor of the pituitary gland ... that causes an excessive amount of growth hormone, which leads to gigantism [source: UCLA]. Obviously, gigantism causes an ... Gigantism. (April 24, 2015) http://pituitary.ucla.edu/body.cfm?id=83 ...
Gigantism and Acromegaly: Practice Essentials, Background, Pathophysiology and Etiology
Gigantism refers to abnormally high linear growth due to excessive action of insulinlike growth factor I (IGF-I) while the ... Gigantism. Gigantism is a nonspecific term that refers to any standing height more than 2 standard deviations above the mean ... Gigantism is extremely rare, with approximately 100 reported cases to date. Acromegaly is more common than gigantism, with an ... encoded search term (Gigantism and Acromegaly) and Gigantism and Acromegaly What to Read Next on Medscape ...
Deep Sea Gigantism - Why Deep Sea Animals Are Big
![Mad Max (2015) | Page 9 | [H]ard|Forum](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAMAAAAoLQ9TAAAAeFBMVEVHcEyYDwieEQm9Fw9yBwGDCwW8GA+hEQqVDwjGGRHGGRGeEAl1CAGYDwixFQ17CQNxBwGNDAa9Fw+RDgeFCwWrFAy9Fw95CQKxFQ2YDwh4CAKeEQmEDAXBGBCfEQqQDgeeEQmEDAWeEQrBGBCrFAyRDgeeEQm3Fw45qFFUAAAAJHRSTlMAHSUy/f7uEQlOQkBoa2s/3HXD68/rO+zV1J/sanCKvN/p6v65GveuAAAAfElEQVQYlZ3PyRKCMBBF0UfmBBWQ0RG1SfL/f2hDuXPHrerNWb0GdlR474J3GLwNPjA8iKQhizNJIsNwyhImM+QB0waLQL+slZh6hmMSuKVn80olLp8VokAbHebI0DLcdQGtLTpdoXszHNS1cBbga8ZxA1X9JtWq3vPJX189uwch5ZmmcAAAAABJRU5ErkJggg==)
Mad Max (2015) | Page 9 | [H]ard|Forum
Is bigger always better - Economies of scale and gigantism in shipping
An academic look at economies of scale and gigantism with a view to answering the question whether bigger is better in shipping ... With gigantism being the most popular trend currently pursued by the worlds major carriers a new global context has ... The trend of Gigantism remains strongly in force and has demonstrated few signs in slowing down. Elucidation to practical ... The purpose of this article was to examine the principle of economies of scale within the context of gigantism. Whilst bigger ...
SPOTLIGHT: 'ABYSSAL GIGANTISM" FROM TWO-MAN GIANT SQUID - Bands do BK
For whales, study shows gigantism is in the genes | Kalkine Media
"Gigantism may bring some advantages such as a lower chance of being preyed upon and a greater chance of obtaining food," Silva ... For whales, study shows gigantism is in the genes. January 19, 2023 01:06 PM -03 , By Reuters * ... "Gigantism in the current cetacean lineage is recent, estimated at approximately 5 million years ago. Before that, there were ... "Our results are among the first to study gigantism in cetaceans from a molecular perspective." The study focused on seven whale ...
GIGANTISM - Causes and Risk Factors, Clinical Manifestations, Diagnostic Evaluations and Management
... ... GIGANTISM - Causes and Risk Factors, Clinical Manifestations, Diagnostic Evaluations and Management. Gigantism is abnormally ... Gigantism is very rare.. CLINICAL MANIFESTATIONS. The child will grow in height, as well as in the muscles and organs. This ... Gigantism begins before epiphyseal closure and causes proportional overgrowth of all body tissues.. CAUSES AND RISK FACTORS. ...
Acromegaly and gigantismPituitary GigantismDeep Sea GiganPatients with gigantismTreat gigantismSymptomsCerebralAbnormalCetaceanAdulthoodPediatricDefinitionSecretionOccursGrowth disorderPubertyPathwaysEndocrineGeneticChildhoodAdultDisorderMutationsSignsBoneGPR101GenesCharacteristicTallCasesRareZealandTreatmentCasePersonShowsPeopleDiseaseTOPICStrong
Acromegaly and gigantism12
- The presence of a strong pipeline will be one of the primary factors driving the acromegaly and gigantism drugs market growth until 2022. (technavio.com)
- Researchers are focusing on launching pipeline molecules for acromegaly and gigantism and most of these molecules are in the Phase III stage of development. (technavio.com)
- Based on the acromegaly and gigantism drugs market insights, this market will register a CAGR of about 3% during the forecast period. (technavio.com)
- According to our analysts, this is one of the key trends that will stimulate the growth of the acromegaly and gigantism drugs market size and share. (technavio.com)
- The acromegaly and gigantism drugs market is moderately fragmented with companies focusing on developing new drugs. (technavio.com)
- By offering a complete analysis of the market's competitive landscape and with information on the products offered by the companies, this acromegaly and gigantism drugs industry analysis report is designed to aid clients identify new growth opportunities and design innovative strategies for strengthening their position in the market. (technavio.com)
- The Americas has always been a key market in the context of global acromegaly and gigantism drugs demand and this is mainly due to the high prevalence of the disease in the region. (technavio.com)
- Additionally, the report will also provide an accurate prediction of the contribution of the various drug class segments to the growth of the acromegaly and gigantism drugs market size. (technavio.com)
- Acromegaly and gigantism are disorders of growth hormone hypersecretion. (github.io)
- When there is an imbalance in the secretion of the growth hormones, it can cause disorders like Acromegaly and Gigantism. (learnanydifference.com)
- Cases of Acromegaly and Gigantism might look the same, but both disorders are very different in how they impact the individual. (learnanydifference.com)
- The main difference between Acromegaly and Gigantism is that Acromegaly happens when the pituitary glands in a human's body secrete excessive amounts of hormones when they become an adult. (learnanydifference.com)
Pituitary Gigantism1
- The most common form of gigantism is known as Pituitary Gigantism. (healthylifestyletips365.com)
Deep Sea Gigan1
- Also known as deep-sea gigantism, this is the tendency for invertebrates and deep sea-dwelling animals to grow to much larger sizes than their shallow water relatives. (hammerfilms.com)
Patients with gigantism3
- It does not undergo diurnal variation and will thus be consistently elevated in GH hyper-secretion and therefore patients with gigantism. (wikipedia.org)
- They have been found to be present in about 29 percent of patients with gigantism. (wikipedia.org)
- The presentation of patients with gigantism is usually dramatic, unlike the insidious onset of acromegaly in adults. (medscape.com)
Treat gigantism1
- Various treatments involving surgery and drugs have been used to treat gigantism. (wikipedia.org)
Symptoms6
- The specific age of onset for gigantism varies between patients and gender, but the common age that excessive growth symptoms start to appear has been found to be around 13 years. (wikipedia.org)
- Typically, these patients also experienced an onset of typical gigantism symptoms before reaching the age of 5. (wikipedia.org)
- What are the symptoms of gigantism? (msdmanuals.com)
- The signs and symptoms of gigantism include excessive growth of organs and muscles, increased height, weakness, and insomnia. (learnanydifference.com)
- One of the signs or symptoms that can be identified in a child having Gigantism is more than average height right from the early age of 10 to 12 years. (learnanydifference.com)
- In the beginning, it is difficult to spot the symptoms of Gigantism or this growth disorder as the initial growth of a child is believed to be growth sprout. (healthylifestyletips365.com)
Cerebral3
Abnormal4
- Gigantism is abnormal growth due to an excess of growth hormone (GH) during childhood. (medlineplus.gov)
- Gigantism and acromegaly are patterns of abnormal growth caused by having too much growth hormone. (msdmanuals.com)
- A person is diagnosed with Gigantism when there is an abnormal growth in the height and size of the body. (learnanydifference.com)
- Although not so rare in occurrence, a child who is diagnosed with Gigantism starts to develop abnormal growth either in some parts of the body or the whole body. (learnanydifference.com)
Cetacean1
- Gigantism in the current cetacean lineage is recent, estimated at approximately 5 million years ago. (kalkinemedia.com)
Adulthood1
- However, unlike Acromegaly, Gigantism does not start in adulthood. (learnanydifference.com)
Pediatric1
- Pediatric gigantism patients have shown to have duplications of genes on a specific chromosome, Xq26. (wikipedia.org)
Definition1
- According to Gigantism Definition, a person grows significantly above the average height. (healthylifestyletips365.com)
Secretion2
- Gigantism is the primary example of growth hormone hyper-secretion disorders, a group of illnesses that are not yet deeply understood. (wikipedia.org)
- Apart from the excessive secretion of growth hormone, other reasons can cause Gigantism. (learnanydifference.com)
Occurs3
- Gigantism occurs when growth hormone hypersecretion occurs before the fusion of the long bone epiphysis and is characterized by tall stature. (github.io)
- Gigantism occurs before a person hits puberty or before 15 years of age. (learnanydifference.com)
- Gigantism is an extremely rare disease that occurs when there's too much growth hormone before the bone plates have fused. (bewellbuzz.com)
Growth disorder1
- Gigantism is a growth disorder where almost all parts of the body grow more than average due to the oversecretion of growth hormones. (learnanydifference.com)
Puberty2
- The usual age when Gigantism starts is during puberty or the age of 13 to 15 years. (learnanydifference.com)
- Gigantism can also cause delayed puberty, vision problems, and weakness. (bewellbuzz.com)
Pathways1
- Optic pathway glioma infiltrating into somatostatinergic pathways in a young boy with gigantism. (bvsalud.org)
Endocrine2
- Additionally, a large variety of other known genetic disorders have been found to influence the development of gigantism such as multiple endocrine neoplasia type 1 and 4, McCune-Albright syndrome, Carney complex, familial isolated pituitary adenoma, X-linked acrogigantism (X-LAG). (wikipedia.org)
- Ailments and disorders like McCune-Albright syndrome, inherited carney complex, endocrine neoplasia, etc can contribute to the growth of tumors that can in turn be a cause for Gigantism. (learnanydifference.com)
Genetic3
- Finding a specific genetic cause for gigantism has proven to be difficult. (wikipedia.org)
- Researchers have identified a gene on the X chromosome, GPR101 , which was overexpressed 1000-fold more than normal in a genetic study of 43 patients affected by sporadic or inherited gigantism that manifested during childhood or adolescence. (medscape.com)
- A new study explored the genetic underpinnings of gigantism in whales, identifying four genes that appear to have played crucial roles. (kalkinemedia.com)
Childhood3
- Gigantism refers to abnormally high linear growth (see the image below) due to excessive action of insulinlike growth factor I (IGF-I) while the epiphyseal growth plates are open during childhood. (medscape.com)
- On the other hand, Gigantism happens when the pituitary glands in a human's body oversecrete hormones during childhood. (learnanydifference.com)
- The occurrence of Gigantism is more during the childhood or growing years of an individual. (learnanydifference.com)
Adult1
- Gigantism should not be confused with acromegaly, the adult form of the disorder, characterized by somatic enlargement specifically in the extremities and face. (wikipedia.org)
Disorder1
- Gigantism is a hormonal disorder. (healthylifestyletips365.com)
Mutations3
- Some common mutations have been associated with gigantism. (wikipedia.org)
- Additionally, DNA mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene are common in gigantism patients. (wikipedia.org)
- Mutations in AIP sequencing can have deleterious effects by inducing the development of pituitary adenomas which in turn can cause gigantism. (wikipedia.org)
Signs1
- The trend of Gigantism remains strongly in force and has demonstrated few signs in slowing down. (shippingandfreightresource.com)
Bone3
- Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are two substances that have been identified as influencing growth plate formation and bone growth and, therefore, gigantism. (wikipedia.org)
- Gigantism is abnormally large growth due to an excess of growth hormone during child-hood, before the bone growth plates have closed. (canestar.com)
- Characteristic plurifocal overgrowths (partial or regional gigantism) can involve any structure of the body but most commonly involve the bone, connective tissue, and fat. (medscape.com)
GPR1012
- and 10% had X-linked acro-gigantism (X-LAG) due to chromosome Xq26.3 microduplications on the GPR101 gene. (medscape.com)
- Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (medscape.com)
Genes1
- The lack of shared positive selected genes between different large-bodied whale species supports a previously proposed convergent evolution of gigantism and hence cancer resistance in baleen whales. (lu.se)
Characteristic1
- Haast's eagle is a characteristic example of island gigantism. (otago.ac.nz)
Tall1
- It is important to see that there are several people in the world who on the other side are so tall because they are affected by a disease name gigantism. (healthylifestyletips365.com)
Cases1
- The cases of gigantism can be found across the history and on every continent. (healthylifestyletips365.com)
Rare1
- Gigantism is very rare. (medlineplus.gov)
Zealand1
- Island gigantism, Mana Island, New Zealand (NZ). (naturespic.com)
Treatment1
- This, in turn, results in a strong pipeline for gigantism and acromegaly treatment. (technavio.com)
Case1
- He was also the case of gigantism. (healthylifestyletips365.com)
Person1
- How can doctors tell if a person has gigantism or acromegaly? (msdmanuals.com)
Shows1
- This graph shows the total number of publications written about "Gigantism" by people in this website by year, and whether "Gigantism" was a major or minor topic of these publications. (jefferson.edu)
People2
- People with untreated gigantism and acromegaly have a shorter life expectancy. (msdmanuals.com)
- Below are the most recent publications written about "Gigantism" by people in Profiles. (jefferson.edu)
Disease1
- Gigantism is a disease of children. (msdmanuals.com)
TOPIC1
- In this episode, we review the high-yield topic of Macrodactyly (local gigantism) from the Hand section. (orthohub.xyz)
Strong1
- Male predominance was seen among AIP -mutated gigantism, whereas X-LAG had a strong female predilection. (medscape.com)
![Mad Max (2015) | Page 8 | [H]ard|Forum](https://hardforum.com/styles/default/xenforo/add_to_home.gif)
