Glomus Tumor
Glomus Jugulare Tumor
Nail Diseases
Aortic Bodies
Imprinting (Psychology)
Genes, Neurofibromatosis 1
Tracheal Neoplasms
Neurofibromatosis 1
Radiography, Abdominal
Paraganglioma
Glomeromycota
Encyclopedias as Topic
Histochemical investigation into the molecular mechanisms of malignant transformation in a benign glomus tumour. (1/77)
A glomangiosarcoma arose in a benign glomus tumour. The histological and immunohistochemical characteristics of the tumour were investigated. Apoptotic cells were identified by terminal deoxynucleotidyl transferase (TdT) mediated dUTP-biotin nick end labelling (TUNEL). The proportion of apoptotic cells was found to be low and TUNEL positive nuclei were present in the benign part of the tumour. Bcl-2 protein, an inhibitor of apoptosis, was strongly expressed in the glomangiosarcoma with only weak staining in the benign area. The proliferation index of the glomangiosarcoma was almost 10-fold higher than that of the benign glomus tumour. Numerous nuclei in the glomangiosarcoma were intensely stained for the tumour suppressor protein p53. The results of the this study may contribute to an understanding of the molecular basis of malignant transformation in benign glomus tumours. (+info)A gene for inherited cutaneous venous anomalies ("glomangiomas") localizes to chromosome 1p21-22. (2/77)
Venous malformations (VMs) are localized defects of vascular morphogenesis. They can occur in every organ system, most commonly in skin and muscle. They can cause pain and bleeding, and in some critical locations they can be life threatening. Usually venous anomalies occur sporadically, but families with dominant inheritance have been identified. Using linkage analysis, we have established in earlier reports that some families with inherited VMs show linkage to chromosome 9p21; the mutation causes ligand-independent activation of an endothelial cell-specific receptor tyrosine kinase, TIE-2. Here we show that VMs with glomus cells (known as "glomangiomas"), inherited as an autosomal dominant trait in five families, are not linked to 9p21 but, instead, link to a new locus, on 1p21-p22, called "VMGLOM" (LOD score 12.70 at recombination fraction.00). We exclude three known positional candidate genes, DR1 (depressor of transcription 1), TGFBR3 (transforming growth factor-beta receptor, type 3), and TFA (tissue factor). We hypothesize that cutaneous venous anomalies (i.e., glomangiomas) are caused by mutations in a novel gene that may act to regulate angiogenesis, in concert with the TIE-2 signaling pathway. (+info)Additional glomangioma families link to chromosome 1p: no evidence for genetic heterogeneity. (3/77)
Venous malformations are a common abnormality of the vasculature that may occur sporadically or, more rarely, as an autosomal dominant trait. One familial form of venous malformations has previously been linked to chromosome 9p. Mutations in the gene encoding Tie2, an endothelial specific receptor tyrosine kinase, have been identified in four different families. Glomangiomas are a subtype of venous malformations with glomus cell involvement. These cutaneous lesions can be inherited as an autosomal dominant disease with reduced penetrance and variable expressivity. We present evidence of linkage to chromosome 1p21-1p22 using four new glomangioma families, with a combined maximum two-point lod score of 7.32 at marker D1S2804. Markers D1S2129 and D1S2881 define the 24-cM linkage interval determined by recombination within affected individuals. A recent report also showed linkage of the glomangioma locus to chromosome 1p. A total of 9 families now map to this region, suggesting a decreased likelihood of locus heterogenity in familial glomangiomas. Investigation of candidate genes within the interval should provide new insights into lesion formation in inherited venous malformations. (+info)Linkage disequilibrium narrows locus for venous malformation with glomus cells (VMGLOM) to a single 1.48 Mbp YAC. (4/77)
Venous malformations with glomus cells are localised cutaneous lesions of vascular dysmorphogenesis. They are usually sporadic, but sometimes familial. Using five families, we mapped the locus, VMGLOM, to chromosome 1p21-p22. In order to refine this locus, spanning 4-6 Mbp, we then studied seven additional families. They exhibited linkage to VMGLOM and the combined lod score for all 12 families was 18.41 at theta = 0.0 for marker D1S188. We found a distinct haplotype shared by seven families, comprising seven alleles which are rare in the general population (P < 0.01). This indicates that the haplotype is identical by descent in all seven families, and hence the locus can be refined by inferring ancestral crossovers. Using this approach, we position the causative gene between two markers on the same non-chimeric YAC of 1.48 Mbp, a feasible size for positional cloning. As there is no known gene involved in vasculogenesis and/or angiogenesis in this YAC, the identification of the causative gene is likely to reveal a novel regulator or vascular development. (+info)A rare case of bronchial glomus tumor. (5/77)
A 48-year-old man was admitted because of bloody sputum in whom a chest computed tomography (CT) scan and fiberoptic bronchoscopy demonstrated a polypoid tumor in the left main bronchus. The tumor was surgically resected, and the pathological and immunohistochemical findings led to diagnosis of the tumor as a bronchial glomus tumor. (+info)Unusual eustachian tube mass: glomus tympanicum. (6/77)
SUMMARY: A case of recurrent glomus tympanicum presenting with epistaxis is described. CT and MR imaging revealed a homogeneously enhancing mass extending along the entire course of the eustachian tube, with a portion protruding into the nasopharynx. Glomus tumors tend to spread along the path of least resistance and may extend into the eustachian tube. The unique imaging appearance should place a glomus tumor high on the list of differential diagnoses. (+info)Juxtaglomerular cell tumor: a clinicopathologic study of four cases and review of the literature. (7/77)
We studied 4 new cases of juxtaglomerular cell tumor and compared their morphologic and immunohistochemicalfeatures with 2 renal hemangiopericytomas and 5 cutaneous glomus tumors. The juxtaglomerular tumors were resectedfrom 2 males and 2 females (mean age at diagnosis, 23 years). Three patients manifested with severe hypertension. Tumors ranged from 2.2 to 8.0 cm and were well circumscribed. The tumors consisted of solid sheets and nodules of variably sized tumor cells with round, oval, and spindled nuclei alternating with edematous microcystic foci. Nuclear atypia, present in all tumors, was a prominent feature in 2. Mitotic activity was not identified. All cases showed hemorrhage, numerous mast cells, and thick-walled blood vessels. Unusual features included coagulative tumor necrosis, a hemangiopericytoma-like vascular pattern, and hyalinized stroma. All tumors were immunoreactive for CD34 and actin. Ultrastructural analysis revealed the presence of rhomboid-shaped renin protogranules. Patients were treated by partial or radical nephrectomy and followed up for 14 to 48 months. There were no recurrences or metastases. The characteristic clinical and morphologic features of juxtaglomerular cell tumor permit distinction from renal hemangiopericytoma and other renal tumors. (+info)Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). (8/77)
Glomuvenous malformations (GVMs) are cutaneous venous lesions characterized by the presence of smooth-muscle--like glomus cells in the media surrounding distended vascular lumens. We have shown that heritable GVMs link to a 4--6-cM region in chromosome 1p21-22. We also identified linkage disequilibrium that allowed a narrowing of this VMGLOM locus to 1.48 Mb. Herein, we report the identification of the mutated gene, glomulin, localized on the basis of the YAC and PAC maps. An incomplete cDNA sequence for glomulin had previously been designated "FAP48," for "FKBP-associated protein of 48 kD." The complete cDNA for glomulin contains an open reading frame of 1,785 nt encoding a predicted protein of 68 kD. The gene consists of 19 exons in which we identified 14 different germline mutations in patients with GVM. In addition, we found a somatic "second hit" mutation in affected tissue of a patient with an inherited genomic deletion. Since all but one of the mutations result in premature stop codons, and since the localized nature of the lesions could be explained by Knudson's two-hit model, GVMs are likely caused by complete loss of function of glomulin. The abnormal phenotype of vascular smooth-muscle cells (VSMCs) in GVMs suggests that glomulin plays an important role in differentiation of these cells--and, thereby, in vascular morphogenesis--especially in cutaneous veins. (+info)A Glomus tumor is a rare, benign (non-cancerous) neoplasm that arises from the glomus body, a specialized form of blood vessel found in the skin, particularly in the fingers and toes. These tumors are highly vascular and usually appear as small, blue or red nodules just beneath the nail bed or on the fingertips. They can also occur in other parts of the body such as the stomach, lung, and kidney, but these locations are much less common.
Glomus tumors typically present with symptoms like severe pain, especially when exposed to cold temperatures or pressure. The pain is often described as sharp, stabbing, or throbbing, and it can be debilitating for some individuals. Diagnosis of glomus tumors usually involves a physical examination, imaging studies such as MRI or CT scans, and sometimes biopsy. Treatment options include surgical excision, which is often curative, and in some cases, embolization or sclerotherapy may be used to reduce the blood flow to the tumor before surgery.
A Glomus Jugulare Tumor is a rare, usually benign, slow-growing tumor that develops from the glomus body, a small collection of modified blood vessels involved in temperature regulation, located near the jugular bulb in the skull. This type of tumor can cause symptoms such as hearing loss, pulsatile tinnitus (a rhythmic sound in the ear), and cranial nerve palsies due to its proximity to critical structures in the head and neck. Treatment typically involves surgical removal or radiation therapy.
Nail diseases, also known as onychopathies, refer to a group of medical conditions that affect the nail unit, which includes the nail plate, nail bed, lunula, and surrounding skin (nail fold). These diseases can be caused by various factors such as fungal infections, bacterial infections, viral infections, systemic diseases, trauma, and neoplasms.
Some common examples of nail diseases include:
1. Onychomycosis - a fungal infection that affects the nail plate and bed, causing discoloration, thickening, and crumbling of the nail.
2. Paronychia - an infection or inflammation of the nail fold, caused by bacteria or fungi, resulting in redness, swelling, and pain.
3. Ingrown toenails - a condition where the nail plate grows into the surrounding skin, causing pain, redness, and infection.
4. Onycholysis - a separation of the nail plate from the nail bed, often caused by trauma or underlying medical conditions.
5. Psoriasis - a systemic disease that can affect the nails, causing pitting, ridging, discoloration, and onycholysis.
6. Lichen planus - an inflammatory condition that can affect the skin and nails, causing nail thinning, ridging, and loss.
7. Melanonychia - a darkening of the nail plate due to pigmentation, which can be benign or malignant.
8. Brittle nails - a condition characterized by weak, thin, and fragile nails that easily break or split.
9. Subungual hematoma - a collection of blood under the nail plate, often caused by trauma, resulting in discoloration and pain.
10. Tumors - abnormal growths that can develop in or around the nail unit, ranging from benign to malignant.
Accurate diagnosis and treatment of nail diseases require a thorough examination and sometimes laboratory tests, such as fungal cultures or skin biopsies. Treatment options vary depending on the underlying cause and may include topical or oral medications, surgical intervention, or lifestyle modifications.
Aortic bodies, also known as aortic arch chemoreceptors or simply as carotid and aortic bodies, are small clusters of nerve cells located near the bifurcation of the common carotid artery (carotid body) and in the wall of the aortic arch (aortic body). They are part of the peripheral chemoreceptor system that responds to changes in chemical composition of the blood, particularly to decreases in oxygen levels, increases in carbon dioxide levels, and changes in pH. These receptors send signals to the brainstem, which in turn regulates breathing rate and depth to maintain adequate gas exchange and acid-base balance in the body.
Bronchial neoplasms refer to abnormal growths or tumors in the bronchi, which are the large airways that lead into the lungs. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Malignant bronchial neoplasms are often referred to as lung cancer and can be further classified into small cell lung cancer and non-small cell lung cancer, depending on the type of cells involved.
Benign bronchial neoplasms are less common than malignant ones and may include growths such as papillomas, hamartomas, or chondromas. While benign neoplasms are not cancerous, they can still cause symptoms and complications if they grow large enough to obstruct the airways or if they become infected.
Treatment for bronchial neoplasms depends on several factors, including the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
Neurofibromatosis 1 (NF1) is a genetic disorder caused by mutations in the NF1 gene, which is located on chromosome 17 and encodes the protein neurofibromin. Neurofibromin is a tumor suppressor protein that regulates cell growth and differentiation.
The NF1 gene mutation leads to the development of benign (non-cancerous) tumors on nerves and skin, called neurofibromas, as well as other clinical features such as café-au-lait spots (light brown patches on the skin), freckling in the axillary or inguinal regions, Lisch nodules (harmless growths on the iris of the eye), and skeletal abnormalities.
Neurofibromatosis 1 is an autosomal dominant disorder, which means that a person has a 50% chance of inheriting the mutated gene from an affected parent. However, up to 50% of cases result from new mutations in the NF1 gene and occur in people with no family history of the condition.
The clinical manifestations of Neurofibromatosis 1 can vary widely among individuals, even within the same family. The diagnosis is typically made based on clinical criteria established by the National Institutes of Health (NIH). Treatment is generally focused on managing symptoms and addressing complications as they arise, although surgery may be necessary to remove large or symptomatic tumors.
Tracheal neoplasms refer to abnormal growths or tumors in the trachea, which is the windpipe that carries air from the nose and throat to the lungs. These growths can be benign (non-cancerous) or malignant (cancerous). Malignant tracheal neoplasms are relatively rare and can be primary (originating in the trachea) or secondary (spreading from another part of the body, such as lung cancer). Primary tracheal cancers can be squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, or sarcomas. Symptoms may include cough, difficulty breathing, wheezing, or chest pain. Treatment options depend on the type, size, and location of the neoplasm and can include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
Neurofibromatosis 1 (NF1) is a genetic disorder that affects the development and growth of nerve tissue. It's also known as von Recklinghausen disease. NF1 is characterized by the growth of non-cancerous tumors on the nerves, as well as skin and bone abnormalities.
The symptoms of Neurofibromatosis 1 can vary widely, even among members of the same family. Some common features include:
* Multiple café au lait spots (flat, light brown patches on the skin)
* Freckles in the underarms and groin area
* Benign growths on or under the skin called neurofibromas
* Larger, more complex tumors called plexiform neurofibromas
* Optic gliomas (tumors that form on the optic nerve)
* Distinctive bone abnormalities, such as a curved spine (scoliosis) or an enlarged head (macrocephaly)
* Learning disabilities and behavioral problems
Neurofibromatosis 1 is caused by mutations in the NF1 gene, which provides instructions for making a protein called neurofibromin. This protein helps regulate cell growth and division. When the NF1 gene is mutated, the production of neurofibromin is reduced or absent, leading to uncontrolled cell growth and the development of tumors.
NF1 is an autosomal dominant disorder, which means that a person has a 50% chance of inheriting the mutated gene from an affected parent. However, about half of all cases are the result of new mutations in the NF1 gene, and occur in people with no family history of the disorder.
There is currently no cure for Neurofibromatosis 1, but treatments are available to manage the symptoms and complications of the disease. These may include medications to control pain or reduce the size of tumors, surgery to remove tumors or correct bone abnormalities, and physical therapy to improve mobility and strength. Regular monitoring by a healthcare team experienced in treating Neurofibromatosis 1 is also important to detect any changes in the condition and provide appropriate care.
Abdominal radiography, also known as a KUB (kidneys, ureters, bladder) X-ray, is a medical imaging technique used to examine the abdominal cavity. It involves using ionizing radiation to produce images of the internal structures of the abdomen, including the bones, organs, and soft tissues.
The procedure typically involves the patient lying down on a table while a specialized X-ray machine captures images of the abdomen from different angles. The images produced can help doctors diagnose and monitor a variety of conditions, such as kidney stones, intestinal obstructions, and abnormalities in the spine or other bones.
Abdominal radiography is a quick, painless, and non-invasive procedure that requires little preparation on the part of the patient. However, it does involve exposure to radiation, so it is typically only used when necessary and when other imaging techniques are not appropriate.
In medical terms, toes are the digits located at the end of the foot. Humans typically have five toes on each foot, consisting of the big toe (hallux), second toe, third toe, fourth toe, and little toe (fifth toe). The bones of the toes are called phalanges, with the exception of the big toe, which has a different bone structure and is composed of a proximal phalanx, distal phalanx, and sometimes a sesamoid bone.
Toes play an essential role in maintaining balance and assisting in locomotion by helping to push off the ground during walking or running. They also contribute to the overall stability and posture of the body. Various medical conditions can affect toes, such as ingrown toenails, bunions, hammertoes, and neuromas, which may require specific treatments or interventions to alleviate pain, restore function, or improve appearance.
Paraganglioma is a rare type of tumor that develops in the nervous system, specifically in the paraganglia. Paraganglia are clusters of specialized nerve cells throughout the body that release hormones in response to stress or physical activity. Most paragangliomas are benign (noncancerous), but some can be malignant (cancerous) and may spread to other parts of the body.
Paragangliomas can occur in various locations, including the head and neck region (called "head and neck paragangliomas") or near the spine, abdomen, or chest (called "extra-adrenal paragangliomas"). When they develop in the adrenal glands, which are located on top of each kidney, they are called pheochromocytomas.
Paragangliomas can produce and release hormones such as epinephrine (adrenaline) and norepinephrine, leading to symptoms like high blood pressure, rapid heart rate, sweating, anxiety, and headaches. Treatment typically involves surgical removal of the tumor, along with medications to manage symptoms and control hormone levels before and after surgery.
Glomeromycota is a phylum of fungi that form arbuscular mycorrhizae, which are symbiotic associations with the roots of most land plants. These fungi exist exclusively as tiny, threadlike structures called hyphae, which penetrate the cells of plant roots and form unique structures called arbuscules where nutrient exchange occurs. The fungi receive carbon from the plant in the form of sugars, while they provide essential mineral nutrients like phosphorus and nitrogen to the plant.
Glomeromycota fungi have a mutualistic relationship with plants, helping them to grow and survive in nutrient-poor soils. They also play a crucial role in soil ecology by promoting aggregate formation, improving soil structure, and increasing its water-holding capacity. These fungi are found worldwide and can be detected in almost all terrestrial ecosystems.
It is worth noting that Glomeromycota fungi lack a sexual reproductive stage, and their identification and classification rely on the morphology of their vegetative structures and molecular data.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
An arteriovenous (AV) anastomosis is a connection or short channel between an artery and a vein that bypasses the capillary bed. In a normal physiological condition, blood flows from the arteries to the capillaries, where oxygen and nutrients are exchanged with the surrounding tissues, and then drains into veins. However, in an AV anastomosis, blood flows directly from the artery to the vein without passing through the capillary network.
AV anastomoses can occur naturally or be created surgically for various medical purposes. For example, they may be created during bypass surgery to reroute blood flow around a blocked or damaged vessel. In some cases, AV anastomoses may also develop as a result of certain medical conditions, such as cirrhosis or arteriovenous malformations (AVMs). AVMs are abnormal connections between arteries and veins that can lead to the formation of an AV anastomosis.
It is important to note that while AV anastomoses can be beneficial in certain medical situations, they can also have negative consequences if they occur inappropriately or become too large. For example, excessive AV anastomoses can lead to high-flow shunts, which can cause tissue damage and other complications.
Glomus tumor
Glomus body
Coccygeal glomus
Temporal bone
Glomangiosarcoma
Paraganglioma
Hildreth's sign
Myopericytoma
Auricular branch of vagus nerve
Eccrine angiomatous hamartoma
Tympanic nerve
Walter Freudenthal
Glomectomy
Glomus
Ricardo Ramina
Cranial auscultation
Juxtaglomerular cell tumor
List of neuromuscular disorders
Health effects from noise
Angioma
Hereditary leiomyomatosis and renal cell cancer syndrome
Hyperhidrosis
Melanonychia
Gastroblastoma
Jugular foramen syndrome
Otology
List of MeSH codes (C04)
Hypoglossal canal
Cerebellopontine angle syndrome
List of skin conditions
Glomus tumor - Wikipedia
Glomus tympanum tumor: MedlinePlus Medical Encyclopedia
Dermatologic Manifestations of Glomus Tumor: Background, Pathophysiology, Etiology
Tracheal Glomus Tumour | Citedby Results | Respiration | Karger Publishers
Paragangliomas & Glomus Tumors | Paragangliomas Tumors
Glomus Jugulare Tumors Treatment & Management: Medical Therapy, Surgical Therapy, Preoperative, Intraoperative, and...
Multiple glomus tumors and segmental neurofibromatosis: There are no coincidences
Glomus Tumors - Dermpath Diagnostics
Glomus Tumor - Pathology - Orthobullets
Videos • Glomus Jugulare Tumor
Glomus tumors - Hard to Diagnose
Dermatologic Manifestations of Glomus Tumor: Background, Pathophysiology, Epidemiology
Glomus tumour of the kidney: a case report and review of the literature<...
AIIMS ENT Topic 12 Glomus tumor | Incus Quiz Private Limited
Imaging of Head and Neck Glomus Tumors (Paragangliomas) - Naqlafshk.com
February 1968 - Volume 41 - Issue 2 : Plastic and Reconstructive Surgery
Cytodiagnosis of glomus tumor- a case report | International Journal of Current Research
Intractable Knee pain….it could be Glomus! - Journal of Bone & Soft Tissue Tumors
MBS Online - G
American Journal of Case Reports | Glomus Tumor Within the Tensor Fascia Lata: A Case Report - Article abstract #938726
June 2021 (Vol. 45, Issue 2) | Glomus Tumor of the Thigh | AMA JVU 452-76 - Society for Vascular Ultrasound
Multicentric Cervical Paraganglioma. Rare Case of Five Locations in One Patient. Case Report and Literature Review
Propuesta de clasificación tomografica preoperatoria para el tumor del cuerpo carotideo Translated title: Proposal for...
Vol. 12 No. 2 (2017) | Faridpur Medical College Journal
Myles L. Pensak, MD,FACS
Bailey OT[au] - Search Results - PubMed
Otology/Neurotology & Lateral Skull Base Surgery
Finger Joint Pain - Symptoms, Causes, Treatments & More
Akash Chadha, PA-C| Plastic Surgery | MedStar Health
Paraganglioma4
- Glomus tumor was also the name formerly (and incorrectly) used for a tumor now called a paraganglioma. (wikipedia.org)
- In 1974, Glenner and Grimley renamed the tumor paraganglioma on the basis of its anatomic and physiologic characteristics. (naqlafshk.com)
- Objective: To report a case of a multiple paraganglioma with 5 concurrent locations and also describe a complication not found in the literature, spontaneous tumor bleeding. (scirp.org)
- Parasympathetic PGLs are most often nonsecreting, although about 30% are associated with elevated levels of the dopamine metabolite 3-methoxytyramine (3-MT). [ 5 ] Pheochromocytoma (PHEO) and sympathetic paraganglioma (SPGL) are catecholamine-secreting tumors. (medscape.com)
Paragangliomas6
- As stated above, these lesions should not be confused with paragangliomas, which were formerly also called glomus tumors in now-antiquated clinical usage. (wikipedia.org)
- Glomus tumors do not arise from glomus cells, but paragangliomas do. (wikipedia.org)
- Paragangliomas tumors (sometimes referred to as glomus, as glomus cells are the place of origin) are a typically benign abnormal cell growth. (knowcancer.com)
- Imaging is the primary investigative modality for glomus tumors of the head and neck (paragangliomas). (naqlafshk.com)
- Paragangliomas (PGLs) are rare neuroendocrine tumors that carry the highest degree of heritability among human neoplasms. (medscape.com)
- Head and neck paragangliomas (HNPGLs) emerge from the parasympathetic nervous systemand are usually benign, slow-growing tumors. (medscape.com)
Majority of glomus tumors are benign2
- The majority of glomus tumors are benign, but they can also show malignant features. (wikipedia.org)
- While the vast majority of glomus tumors are benign, malignant cases have been rarely reported, with such cases typically being locally invasive. (medscape.com)
Excision5
- Surgical excision is the preferred treatment for benign glomus tumors. (wikipedia.org)
- The treatment of choice for solitary glomus tumors is surgical excision. (dermpathdiagnostics.com)
- For multiple glomus tumors, excision may be more difficult because of their poor circumscription and the large number of lesions. (dermpathdiagnostics.com)
- Glomus tumor, Knee, excision biopsy. (jbstjournal.com)
- A laparotomy and presacral tumour excision is a surgical procedure used to. (yashodahospitals.com)
Diagnosis of glomus tumor1
- Careful cytomorphological examination supported by appropriate clinical history should suggest the diagnosis of glomus tumor and help in preoperative diagnosis. (journalcra.com)
Multiple glomus tumors3
- they are plaguelike in appearance and are considered a variant of multiple glomus tumors. (wikipedia.org)
- Multiple glomus tumors. (medscape.com)
- There are two different types of glomus tumors: Solitary and Multiple glomus tumors, which are also known as glomangiomas or glomulovenous malformations. (dermpathdiagnostics.com)
Resection2
- A large retrospective, multicenter, international study analyzed the long-term outcome in 132 patients with primary radiation treatment or radiation after partial resection of a glomus tumor. (medscape.com)
- The tumor had infiltrated the bladder, and a tumorectomy was conducted through partially combined resection. (karger.com)
Stereotactic radiosurgery3
- However, radiation therapy, particularly stereotactic radiosurgery (eg, Gamma Knife surgery), has been shown to provide good tumor growth control with a low risk of treatment-related cranial nerve injury. (medscape.com)
- A German study of 32 patients who underwent stereotactic radiosurgery for glomus jugulare tumors showed that stereotactic linear accelerator (LINAC) radiosurgery achieved excellent long-term tumor control, along with a low rate of morbidity. (medscape.com)
- In a study of 28 patients treated with radiosurgery and 2 patients with stereotactic radiosurgery, crude overall survival, tumor control, clinical control, and long-term grade 1 toxicity rates were 97%, 97%, 97%, and 13% (4/30), respectively. (medscape.com)
Uncommon6
- Glomus tumors are uncommon benign tumors. (cdlib.org)
- Glomus tumors are uncommon benign tumors that originate in the neuromyoarterial elements of the glomus body, an arteriovenous shunt specialized in thermoregulation. (cdlib.org)
- Glomus Tumors are relatively uncommon benign neoplasms that differentiate to become modified smooth muscle cells called glomus cells. (dermpathdiagnostics.com)
- Although glomus tumors usually appear as solitary lesions at 1 site, multiple lesions at multiple sites are not uncommon (see the image below). (naqlafshk.com)
- Glomus tumors are uncommon and are rarely diagnosed on cytopathology. (journalcra.com)
- Extra-digital location of glomus tumour is uncommon [2]. (jbstjournal.com)
Tympanicum tumors2
- Although glomus tympanicum tumors are the most common primary neoplasms of the middle ear, these tumors are the rarest of head and neck glomus tumors. (naqlafshk.com)
- Glomus tympanicum tumors are small sized tumors originating in the middle ear. (earsite.com)
Occur13
- about one third of the cases of multiple tumors occur in those younger than 20 years. (wikipedia.org)
- These tumors most often occur late in life, around age 60 or 70, but they can appear at any age. (medlineplus.gov)
- [ 3 , 4 ] Glomus tumors most frequently occur in areas with high concentrations of glomus bodies, including subungual regions of the fingers and the deep dermis of the hand (palm), forearm, and foot (sole). (medscape.com)
- While glomus tumors predominate on the hands and fingers, these tumors can occur in a wide anatomic distribution, including sites not known to contain glomus cells, such as deep soft tissues, nerve, bone, and abdominal viscera. (medscape.com)
- Interestingly, while glomus tumors predominate on the hands and fingers especially, these tumors can occur in a wide anatomic distribution, to include sites not known to contain glomus cells. (medscape.com)
- These disseminated variants of glomus tumor, known as glomangiomas or glomuvenous malformations, differ clinically from glomus tumors in that they occur more often in children and adolescents, are typically multifocal, and do not have a predilection for subungual sites. (medscape.com)
- Solitary glomus tumors can occur at any age, but they are most frequent in young adults. (medscape.com)
- Carotid body glomus tumors, also called carotid body tumors, occur at the bifurcation of the common carotid artery and arise from the tissue of the normal carotid body (see the image below). (naqlafshk.com)
- Glomus tumors can rarely occur in unusual locations. (jbstjournal.com)
- Glomus tumors are rare, benign, soft-tissue lesions, usually occurring in the hand, but they can occur in other regions of the body, such as the thigh. (amjcaserep.com)
- Most glomus tumors occur in the hand, especially in the subungual region, as it is rich in blood vessels. (amjcaserep.com)
- Glomus tumors can occur in other regions of the body, and this is considered a very rare situation. (amjcaserep.com)
- The multicentric lesions can occur at different life stages not being necessarily simultaneous, a fact that prevents image exam research to be conclusive for tumor presence or absence. (scirp.org)
Glomangioma2
- Glomangioma (20% of cases): Tumors with a prominent vascular component. (wikipedia.org)
- A glomus tumour (glomangioma, tumors of Popoff, or Barré-Masson syndrome) is a benign mesenchymal neoplasm composed of cells which resemble the modified smooth muscle cells of the normal glomus body (glomocytes) [1]. (jbstjournal.com)
Middle ear2
- A glomus tympanum tumor is a tumor of the middle ear and bone behind the ear (mastoid). (medlineplus.gov)
- Glomus tumors of the head and neck are associated with 4 primary locations, the jugular bulb, middle ear cavity, vagus nerve, and carotid body. (naqlafshk.com)
Vascular4
- Glomangiomyoma (5% of cases): Tumors with prominent vascular and smooth muscle components. (wikipedia.org)
- They are highly vascular, locally invasive, slow-growing tumors that frequently involve critical neurovascular structures. (naqlafshk.com)
- Histological examination revealed a well-circumscribed benign lesion with several vascular spaces (Fig. 3a) and solid aggregates of regular round glomus cells with darkly staining basophilic nucleus in a hyaline stroma. (jbstjournal.com)
- Glomus tumor is a benign tumor derived from the vascular wall of the arteriovenous anastomosis complex. (koreamed.org)
Lesions4
- Glomus tumors are usually solitary and small lesions. (wikipedia.org)
- Solitary glomus tumors, particularly subungual lesions, are more common in females than in males. (wikipedia.org)
- however, the true incidence of glomus tumors is unknown, likely as a result of misdiagnosis of many of these lesions as hemangiomas or venous malformations. (medscape.com)
- Glomus tumors are rare, benign, soft-tissue lesions, representing around 1% to 2% of all soft-tissue tumors. (amjcaserep.com)
Carotid7
- About 80% of all glomus tumors are carotid body tumors or glomus jugulare tumors. (naqlafshk.com)
- Haller introduced glomus tumors of the head and neck into the medical record in 1762 when he described a mass at the carotid bifurcation that had a glomus body-like structure. (naqlafshk.com)
- Carotid body tumor. (naqlafshk.com)
- Vagal and Carotid Body Tumors. (scirp.org)
- Abstract Objective: To propose a preoperative classification of patients with Carotid Body Tumor and relate them to postoperative complications. (scienceopen.com)
- Material and methods: All patients operated with a diagnosis of Carotid Body Tumor between 2005 and 2014 at the Obrero Hospital No. 1 of the National Health Fund in La Paz - Bolivia Results: 115 patients with an average age of 52 years (SD±11.725 and a mode of 57 years) were analyzed and operated on, of which 109 (94.80%) corresponded to the female gender with a ratio of 18: 1. (scienceopen.com)
- A carotid body tumor is suspected if a pulsatile mass in the neck is observed. (earsite.com)
Skull base2
- Surgical strategy for communicating tumors in lateral skull base: pre-sigmoid sinus or retro-sigmoid sinus or combined approach? (thieme-connect.de)
- in five patients, tumor extended below the skull base. (ajnr.org)
Clinical4
- Glomus tumors were first described by Hoyer in 1877 while the first complete clinical description was given by Masson in 1924. (wikipedia.org)
- While once considered a subset of glomus tumors, GVMs are now widely considered to be unrelated in pathogenesis given their differences in clinical and histopathologic features. (medscape.com)
- Of 22 patients with glomus jugulare tumors who underwent Gamma Knife surgery, neurologic status improved in 12 patients, 7 showed stable clinical condition, and 3 patients developed new moderate deficits. (medscape.com)
- The usual clinical presentations consist of pain, tenderness at the site of the tumor, and hypersensitivity to cold. (amjcaserep.com)
Blood vessels2
- Clusters of tumor cells (type I cells interspersed with type II cells), called zellballen, are surrounded by a dense network of capillary caliber blood vessels. (naqlafshk.com)
- An angioma or haemangioma is a benign tumour formed by the dilation of blood vessels or the formation of new ones by the proliferation of endothelial cells. (dermnetnz.org)
Tumours2
- 2. De Smet L, Sciot R, Legius E. Multifocal glomus tumours of the fingers in two patients with neurofibromatosis type 1. (cdlib.org)
- Rarely, glomus tumours may have a malignant potential [3]. (jbstjournal.com)
Jugulare tumor1
- Glomus jugulare tumor surgery. (lookfordiagnosis.com)
Histopathology1
- By histopathology, glomus tumors can be termed as follows: Solid glomus tumor (75% of cases): Consisting predominantly of glomus cells, with poor vasculature and rare smooth muscle cells. (wikipedia.org)
Vestibular Schwannoma1
- Schwannomas of the jugular foramen, usually with origin from the ninth nerve, are rare, but the presenting symptoms may be similar to those of a vestibular schwannoma owing to mass effect by tumor growth in the posterior cranial fossa (2-4) . (ajnr.org)
Soft-tissue ne2
- Glomus tumors are rare soft-tissue neoplasms of the neuromyoarterial glomus body that account for approximately 2% of all soft-tissue tumors in the extremities. (medscape.com)
- Glomus tumors are rare soft tissue neoplasms that typically present in adults (ages 20-40 years) as small, blue-red papules or nodules of the distal extremities, with most cases involving subungual sites. (medscape.com)
Rarely5
- Glomus tympanum tumors are rarely cancerous and do not tend to spread to other parts of the body. (medlineplus.gov)
- Nerve damage, which may be caused by the tumor itself or damage during surgery, rarely occurs. (medlineplus.gov)
- Rarely, glomus tumors can undergo malignant transformation or malignant glomus tumors can arise de novo. (medscape.com)
- After review of the literature, we could verify that, although rarely reported, there is a well established relationship between NF1 and glomus tumors, single or multiple. (cdlib.org)
- [ 10 ] SDH- associated syndromes are characterized by the development of PGLs, with an additional risk for developing other tumor types [ e.g. , clear cell renal cancer (RCC), gastrointestinal stromal tumors (GISTs), and, more rarely, neuroendocrine tumors and pituitary adenomas]. (medscape.com)
Histologically4
- Histologically, glomus tumors are made up of an afferent arteriole, anastomotic vessel, and collecting venule. (wikipedia.org)
- Histologically GT arises from glomus bodies that are specialised form of arteriovenous anastomosis involved in temperature regulation. (jbstjournal.com)
- Histologically, GT are divided into 3 subtypes: The classical glomus tumour, glomangiomas and glomangiomyomas, the last being least common. (jbstjournal.com)
- When the origin could be identified, almost all these tumors were histologically proved to be schwannomas of the glossopharyngeal nerve. (ajnr.org)
Normal glomus1
- Glomus tumors are thought to represent hamartomatous proliferations of modified smooth muscle cells originating from preexisting normal glomus cell populations. (medscape.com)
Temporal4
- A glomus tympanum tumor grows in the temporal bone of the skull, behind the eardrum (tympanic membrane). (medlineplus.gov)
- they are the most common tumors of the inner ear and the second most common tumors of the temporal bone after schwannomas . (naqlafshk.com)
- Dall′Igna, C., Antunes, M.B. and Dall′Igna, D.P. (2005) Radiation Therapy for Glomus Tumors of the Temporal Bone. (scirp.org)
- Most tumors emanating from the temporal bone directly affects the internal auditory canal and may prolepses into the auditory nerve endings. (sinuswars.com)
Exceedingly rare1
- Cancerous glomus tumors are exceedingly rare. (wikipedia.org)
Arise7
- Glomus tumors are thought to arise from the glomus body or Sucquet-Hoyer canal, a thermoregulatory arteriovenous shunt composed of modified smooth muscle cells. (medscape.com)
- [ 11 ] These tumors may arise from perivascular cells or pluripotent mesenchymal cells capable of differentiating into glomus cells. (medscape.com)
- Glomus tumors are thought to arise from the glomus body, a thermoregulatory shunt concentrated in the fingers and toes. (medscape.com)
- One explanation for this finding is that these tumors may arise from perivascular cells that can differentiate into glomus cells. (medscape.com)
- multiple tumors-classically seen as glomuvenous malformations-arise in younger patients and tend to be asymptomatic. (medscape.com)
- they arise from the glomus bodies that run with the tympanic branch of the glossopharyngeal nerve. (naqlafshk.com)
- Glomus jugulare arise from paraganglia in or around the jugular bulb, and as they grow they occlude this venous structure. (earsite.com)
Malignancy3
- Malignant glomus tumors, or glomangiosarcomas, are extremely rare and usually represent a locally infiltrative malignancy. (wikipedia.org)
- Criteria for the diagnosis of malignancy in glomus tumors are: Tumor size of more than 2 centimeters and subfascial or visceral location. (wikipedia.org)
- A study from Vanderbilt University found that in the absence of brainstem compression or concern for malignancy, observation of glomus jugulare tumors can be a viable initial management approach for elderly patients. (medscape.com)
Neoplasms3
- Glomus tumors are neoplasms caused by a proliferation of glomus cells, which make up a portion of the glomus body. (dermpathdiagnostics.com)
- Tumors of the cranial nerve sheath constitute 5% to 10% of all intracranial neoplasms, yet few articles have described their CT and MR characteristics. (ajnr.org)
- Cranial nerve sheath tumors constitute 5% to 10% of all intracranial neoplasms. (ajnr.org)
Rare neoplasm1
- A glomus tumor (also known as a "solitary glomus tumor") is a rare neoplasm arising from the glomus body and mainly found under the nail, on the fingertip or in the foot. (wikipedia.org)
Malformations2
- It is thought that GVMs and glomus tumors have different etiologies, with GVMs resembling venous malformations and containing more dilated venous channels than glomus tumors. (medscape.com)
- The multiple variant of glomus tumor - generalized glomuvenous malformations, or multiple glomangiomas - is much less common, accounting for less than 10% of all reported cases. (medscape.com)
Cranial nerve1
- The study found long-term successful control of the tumor growthi and mprovement of tinnitus and overall neurological status, as well as cranial nerve function. (medscape.com)
Anastomotic vessel1
- The glomus body is composed of an afferent arteriole, anastomotic vessel (termed Sucquet-Hoyer canal), primary collecting vein, intraglomerular reticulum, and a capsular portion. (medscape.com)
Cancerous1
- Pericytes of Zimmerman Cancerous glomus tumors have been subdivided into three categories based on their histologic appearance: locally infiltrative glomus tumors (LIGT), glomangiosarcomas arising in benign glomus tumors (GABG), and glomangiosarcomas arising de novo (GADN). (wikipedia.org)
Symptoms3
- Depending upon where the tumor is located, as well as how large it is, there can be various symptoms present. (knowcancer.com)
- Most of the time, extradigital glomus tumors are difficult to diagnose, and symptoms can persist for a long time. (amjcaserep.com)
- Therefore routine examination is not justifiable when symptoms relative to tumor presence are not present. (scirp.org)
Head and neck2
- Tumors affecting the head and neck can cause pain, nerve paralysis, and even some hemorrhaging or inflammation. (knowcancer.com)
- This is the most common type of glomus tumor of the head and neck. (naqlafshk.com)
Bone1
- Schwannoma of the jugular foramen is characteristically a sharply demarcated, contrast-enhancing tumor, typically centered on or based in an enlarged jugular foramen with sharply rounded bone borders and a sclerotic rim. (ajnr.org)
Cell populations1
- Glomus cell populations are specialized arteriovenous anastomoses found most often in the fingers and are characterized by Sucquet-Hoyer canals, which play an important role in thermoregulation. (medscape.com)
Microenvironment1
- Exosomes secreted by cancer cells, malicious exosomes, have important roles in tumor microenvironment maturation and cancer progression. (bvsalud.org)
Bodies3
- Glomus tumors are modified smooth muscle cells that control the thermoregulatory function of dermal glomus bodies. (wikipedia.org)
- This area contains nerve fibers (glomus bodies) that normally respond to changes in body temperature or blood pressure. (medlineplus.gov)
- Glomus bodies play an important role in thermoregulation via arteriovenous shunting. (medscape.com)
Histopathological1
- The tumor was a huge lesion occupying the inside of the lumen, and histopathological findings revealed that the tumor, the main part of which lay beneath the mucous membrane, had a transitional image composed of both spindle-shaped atypical cells and sarcomatoid shape. (karger.com)
Distal extremities1
- The most common location for these tumors is the distal extremities, especially in subungual areas. (dermpathdiagnostics.com)
Benign mesenchymal1
- Lipoma is the most frequent benign mesenchymal tumor. (koreamed.org)
Neuroendocrine1
- Because they are parts of the neuroendocrine system, these tumors are highly vascularized. (naqlafshk.com)
Neurofibromatosis3
- An epidemiologic relationship may exist between glomus tumors and neurofibromatosis, which most often produces subungual glomus tumors. (medscape.com)
- 3. Rutkowski JL, Wu K, Gutmann DH, Boyer PJ, Legius E. Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. (cdlib.org)
- About 130 patients with neurogenic tumors of the jugular foramen without associated neurofibromatosis have been reported. (ajnr.org)
Vasculature1
- The three components of most glomus tumors include glomus cells, vasculature, and smooth muscle cells. (medscape.com)