Unusual tumor affecting any site of the body, but most often encountered in the head and neck. Considerable debate has surrounded the histogenesis of this neoplasm; however, it is considered to be a myoblastoma of, usually, a benign nature. It affects women more often than men. When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma.
'Gingival neoplasms' are abnormal, uncontrolled growths of tissue originating from the gingiva, which can be benign (non-cancerous) or malignant (cancerous), often manifesting as swellings, ulcerations, or masses within the oral cavity.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Tumors or cancer of the TONGUE.
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Diseases of domestic and wild horses of the species Equus caballus.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.

Malignant granular cell tumor at the retrotracheal space. (1/86)

We report a case of an extremely rare neoplasm, malignant granular cell tumor (MGCT). The patient was a 21-year-old woman, who was 5 months pregnant. The tumor occurred in the retrotracheal space, extending from the level of the larynx to the thoracic inlet. In addition, there were multiple, variable-sized tumor nodules within both lung fields on chest CT scan. Histologically, tissue biopsied from the periphery of the tumor consisted of solid sheets of large ovoid cells with ample, eosinophilic cytoplasm, eccentric nuclei, and prominent nucleoli. Each cell showed slight atypism of the nuclei. There was a focal necrosis at the periphery of the lesion. These cells stained strongly for S-100 protein, neuron-specific enolase (NSE) and CD68. On electron microscopy, the tumor cells contained autophagic vacuoles. The patient refused further treatment and died 7 months later. The exact cause of death was not known. Until now, the diagnosis of MGCTs has been made only when metastasis and an aggressive clinical course are identified, although some observers advocate that some histologic features such as nuclear pleomorphism, necrosis, and the presence of any mitotic activity are indicative of malignancy. These histologic findings are not easily detectable in every case of MGCT, as in our case. So the diagnosis of a MGCT should be considered in cases with aggressive clinical findings and some histologic features, such as necrosis, nuclear atypism, and mitotic activities, which could suggest the malignant behavior of this neoplasm.  (+info)

Granular cell lesions in the distal female reproductive tract of aged Sprague-Dawley rats. (2/86)

During the review of a rat carcinogenicity study, a spectrum of granular cell lesions was recognized in the distal female reproductive tract. To verify the diagnoses, cell populations of nine granular cell alterations of the cervix or vagina were characterized immunohistochemically and four were evaluated ultrastructurally. Immunoreactivity was demonstrated in 8/9 cases with S100 protein, 6/9 cases with neuron-specific enolase, and 7/9 cases with Leu-7. Granular cells were negative for smooth muscle-specific actin and calretinin. The immunohistochemical profile of these lesions was similar to that previously reported in other species, including humans. Ultrastructurally, as expected many lysosomal bodies were present in the cytoplasm of granular cells in all specimens evaluated. Based on the detailed evaluation of a series of lesions, we adopted the following diagnostic criteria and nomenclature for the granular cell changes of the female reproductive tract of rats. Granular cell aggregates were non-space-occupying lesions composed of clusters of typical granular cells. Benign granular cell tumors were space occupying lesions that typically contained prominent interstitial collagen and were either discrete masses or were difficult to discern from the surrounding tissues. Some benign tumors also contained foci of spindle cells with decreased granularity. Malignant tumors exhibited pleomorphism and an increased nucleus: cytoplasm ratio morphologically but had the same biologic behavior as the benign tumors. We applied these diagnostic criteria during the review of controls from 9 carcinogenicity studies. Up to 23% of control females in those carcinogenicity studies had granular cell lesions that could be classified into one of the three categories. Granular cell lesions appear to be common in the cervix/vagina of the Sprague-Dawley rat, and tumors may develop from granular cell aggregates.  (+info)

Granular cell tumor of the breast. (3/86)

We report a case of granular cell tumor of the breast presenting as a spiculated lesion mimicking carcinoma on mammography and ultrasonography (US).  (+info)

Aromatase inhibitors prevent spontaneous granular cell tumors in the distal female reproductive tract of Sprague-Dawley rats. (4/86)

We recently established diagnostic criteria for granular cell changes in the distal female reproductive tract of rats. In a review of control animals from 9 carcinogenicity studies, we found that approximately 23% of animals had granular cell alterations. Because estrogen may play a role in the pathogenesis of granular cell alterations, we reviewed tissue sections from carcinogenicity studies with 2 aromatase inhibitors and found compound-related decreases in the incidence of granular cell changes. Since these aromatase inhibitors selectively prevent the conversion of androgenic steroids to the corresponding estrogens, these data further suggest that estrogen may play a role in the pathogenesis of granular cell tumors of the reproductive tract of rats.  (+info)

Nine cases of granular cell tumors in B6C3F1 mice. (5/86)

The histological characteristics of 9 cases of granular cell tumors (GCTs) observed in B6C3F1 mice were examined to determine their cellular origin. Seven of the 9 cases were found in the uterus and other 2 cases were in the subcutaneous tissue. Tumor cells had abundant granules in the cytoplasm which were stained with PAS and were resistant to diastase treatment. Ultrastructurally, the granules were identified as lysosomes. The cell surface had cytoplasmic processus showing interdigitation with adjacent cells. A character feature of the tumor cells was the presence of a desmosome-like structure on their cell surface but no basal lamina was demonstrated. Although GCTs have been considered to be derived from Schwann cells on the basis of their ultrastructural features and S-100 protein-immunopositive findings, the absence of basal lamina in the present cases may raise a controversy as to their origin.  (+info)

Symptomatic granular cell tumor involving the pituitary gland in a dog: a case report and review of the literature. (6/86)

A granular cell tumor involving the pituitary gland, optic chiasm and ventral pyriform lobes was discovered in a 12-year-old Labrador Retriever. Clinical signs included acute blindness, seizures, ataxia, weakness, and behavioral changes. The diagnosis was established by histopathologic and ultrastructural examination of neoplastic tissues collected at necropsy. Granular cell tumors involving the central nervous system are well documented in humans but rarely have been described in dogs. The location of the neoplasm and the clinical symptoms seen in this dog closely parallel those of a rare syndrome in humans commonly described as symptomatic parasellar or pituitary granular cell tumors. The cell of origin for these tumors is still highly debated, and attempts to characterize human granular cell tumors through immunohistochemistry have produced conflicting results. An immunohistochemical profile of this neoplasm revealed focal positive staining for vimentin with a lack of staining for neuron-specific enolase, glial fibrillary acidic protein, S-100, and synaptophysin. All neoplastic cells were strongly positive with the periodic acid-Schiff reaction.  (+info)

Granular cell tumor of the canine central nervous system: two cases. (7/86)

Although pure granular cell tumors have been reported in various sites in the dog, only one tumor has been reported in the central nervous system. Two dogs presented with neurologic signs had brain lesions detected by magnetic resonance imaging in the area of the olfactory bulbs and frontal cortex. In both dogs, a clinical diagnosis of a granular cell tumor was made from tissues obtained from stereotactic biopsies guided by computed tomography. Surgical removal of the tumors was followed by histopathologic, ultrastructural, and immunocytochemical characterization. Although not conclusive, these studies indicated that the granular cells were not of leucocyte origin but may have been derived from the meninges. One dog died 12 months after surgery, and the other was alive 4 months later.  (+info)

Granular cell tumor of the palate: a case report. (8/86)

Granular cell tumor (GCT) is an infrequent benign neoplasm, which Abrikosoff accurately described in 1926. GCT probably has a neural crest cell origin. We present the clinical and imaging findings in a 45-year-old woman with a GCT involving the palate. CT and MR imaging revealed perineural tumor spread along the greater and lesser palatine nerves. We emphasize the peculiarity of the palatine location and the perineural spread of GCTs.  (+info)

A Granular Cell Tumor (GCT) is a rare, usually benign neoplasm that can occur in various parts of the body. These tumors are typically composed of large polygonal cells with abundant eosinophilic granular cytoplasm, which contain numerous mitochondria. They often involve the skin and subcutaneous tissues, but they can also arise in the oral cavity, gastrointestinal tract, respiratory system, and other visceral organs.

Granular Cell Tumors are thought to originate from Schwann cells, which are nerve sheath cells, although their exact origin is still a matter of debate. They usually present as solitary, slow-growing nodules or masses that are often painless, but they can become symptomatic if they involve sensitive areas or if they undergo malignant transformation, which occurs in about 1-2% of cases.

The diagnosis of Granular Cell Tumors is usually made based on histopathological examination of a biopsy specimen. Immunohistochemical staining can be used to confirm the Schwann cell origin of these tumors, as they typically express S-100 protein and other markers of neural differentiation.

Treatment options for Granular Cell Tumors depend on their location, size, and behavior. Solitary, benign tumors can often be excised surgically with a wide margin to reduce the risk of recurrence. However, malignant tumors or those that cannot be completely removed may require more aggressive treatment, such as radiation therapy or chemotherapy. Regular follow-up is recommended to monitor for recurrence or metastasis.

Gingival neoplasms refer to abnormal growths or tumors that occur in the gingiva, which are the part of the gums that surround the teeth. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms include conditions such as fibromas, papillomas, and hemangiomas, while malignant neoplasms are typically squamous cell carcinomas.

Gingival neoplasms can present with a variety of symptoms, including swelling, bleeding, pain, and loose teeth. They may also cause difficulty with chewing, speaking, or swallowing. The exact cause of these neoplasms is not always known, but risk factors include tobacco use, alcohol consumption, poor oral hygiene, and certain viral infections.

Diagnosis of gingival neoplasms typically involves a thorough clinical examination, including a dental exam and biopsy. Treatment options depend on the type and stage of the neoplasm, but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular dental check-ups and good oral hygiene practices can help to detect gingival neoplasms at an early stage and improve treatment outcomes.

Neoplasms in muscle tissue refer to abnormal and excessive growths of muscle cells that can be benign or malignant. These growths can arise from any of the three types of muscle tissue: skeletal, cardiac, or smooth muscle. Neoplasms in muscle tissue are classified based on their origin, behavior, and histological features.

Benign neoplasms in muscle tissue include leiomyomas (smooth muscle), rhabdomyomas (skeletal muscle), and myxomas (cardiac muscle). These tumors are usually slow-growing and do not invade surrounding tissues or spread to other parts of the body.

Malignant neoplasms in muscle tissue, also known as sarcomas, include leiomyosarcoma (smooth muscle), rhabdomyosarcoma (skeletal muscle), and angiosarcoma (cardiac muscle). These tumors are aggressive, invasive, and have the potential to metastasize to other parts of the body.

Symptoms of neoplasms in muscle tissue depend on their location, size, and type. They may include a painless or painful mass, weakness, fatigue, weight loss, and difficulty swallowing or breathing. Treatment options for neoplasms in muscle tissue include surgery, radiation therapy, chemotherapy, and targeted therapy. The choice of treatment depends on the type, stage, location, and patient's overall health condition.

Tongue neoplasms refer to abnormal growths or tumors that develop in the tongue tissue. These growths can be benign (non-cancerous) or malignant (cancerous).

Benign tongue neoplasms may include entities such as papillomas, fibromas, or granular cell tumors. They are typically slow growing and less likely to spread to other parts of the body.

Malignant tongue neoplasms, on the other hand, are cancers that can invade surrounding tissues and spread to other parts of the body. The most common type of malignant tongue neoplasm is squamous cell carcinoma, which arises from the thin, flat cells (squamous cells) that line the surface of the tongue.

Tongue neoplasms can cause various symptoms such as a lump or thickening on the tongue, pain or burning sensation in the mouth, difficulty swallowing or speaking, and unexplained bleeding from the mouth. Early detection and treatment are crucial for improving outcomes and preventing complications.

S100 proteins are a family of calcium-binding proteins that are involved in the regulation of various cellular processes, including cell growth and differentiation, intracellular signaling, and inflammation. They are found in high concentrations in certain types of cells, such as nerve cells (neurons), glial cells (supporting cells in the nervous system), and skin cells (keratinocytes).

The S100 protein family consists of more than 20 members, which are divided into several subfamilies based on their structural similarities. Some of the well-known members of this family include S100A1, S100B, S100 calcium-binding protein A8 (S100A8), and S100 calcium-binding protein A9 (S100A9).

Abnormal expression or regulation of S100 proteins has been implicated in various pathological conditions, such as neurodegenerative diseases, cancer, and inflammatory disorders. For example, increased levels of S100B have been found in the brains of patients with Alzheimer's disease, while overexpression of S100A8 and S100A9 has been associated with the development and progression of certain types of cancer.

Therefore, understanding the functions and regulation of S100 proteins is important for developing new diagnostic and therapeutic strategies for various diseases.

The descending colon is a part of the large intestine in the human digestive system. It is called "descending" because it is located inferiorly and posteriorly to the transverse colon, and its direction goes downward as it continues toward the rectum. The descending colon receives digested food material from the transverse colon via the splenic flexure, also known as the left colic flexure.

The primary function of the descending colon is to absorb water, electrolytes, and any remaining nutrients from the undigested food materials that have passed through the small intestine. The descending colon also stores this waste material temporarily before it moves into the rectum for eventual elimination from the body.

The descending colon's wall contains a layer of smooth muscle, which helps propel the waste material along the gastrointestinal tract via peristalsis. Additionally, the inner mucosal lining of the descending colon contains numerous goblet cells that produce and secrete mucus to lubricate the passage of stool and protect the intestinal wall from irritation or damage caused by waste materials.

In summary, the medical definition of 'Colon, Descending' refers to a section of the large intestine responsible for absorbing water and electrolytes while storing and eliminating waste materials through peristaltic movements and mucus secretion.

There is no medical definition for "dog diseases" as it is too broad a term. However, dogs can suffer from various health conditions and illnesses that are specific to their species or similar to those found in humans. Some common categories of dog diseases include:

1. Infectious Diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include distemper, parvovirus, kennel cough, Lyme disease, and heartworms.
2. Hereditary/Genetic Disorders: Some dogs may inherit certain genetic disorders from their parents. Examples include hip dysplasia, elbow dysplasia, progressive retinal atrophy (PRA), and degenerative myelopathy.
3. Age-Related Diseases: As dogs age, they become more susceptible to various health issues. Common age-related diseases in dogs include arthritis, dental disease, cancer, and cognitive dysfunction syndrome (CDS).
4. Nutritional Disorders: Malnutrition or improper feeding can lead to various health problems in dogs. Examples include obesity, malnutrition, and vitamin deficiencies.
5. Environmental Diseases: These are caused by exposure to environmental factors such as toxins, allergens, or extreme temperatures. Examples include heatstroke, frostbite, and toxicities from ingesting harmful substances.
6. Neurological Disorders: Dogs can suffer from various neurological conditions that affect their nervous system. Examples include epilepsy, intervertebral disc disease (IVDD), and vestibular disease.
7. Behavioral Disorders: Some dogs may develop behavioral issues due to various factors such as anxiety, fear, or aggression. Examples include separation anxiety, noise phobias, and resource guarding.

It's important to note that regular veterinary care, proper nutrition, exercise, and preventative measures can help reduce the risk of many dog diseases.

A neurilemmoma, also known as schwannoma or peripheral nerve sheath tumor, is a benign, slow-growing tumor that arises from the Schwann cells, which produce the myelin sheath that surrounds and insulates peripheral nerves. These tumors can occur anywhere along the course of a peripheral nerve, but they most commonly affect the acoustic nerve (vestibulocochlear nerve), leading to a type of tumor called vestibular schwannoma or acoustic neuroma. Neurilemmomas are typically encapsulated and do not invade the surrounding tissue, although larger ones may cause pressure-related symptoms due to compression of nearby structures. Rarely, these tumors can undergo malignant transformation, leading to a condition called malignant peripheral nerve sheath tumor or neurofibrosarcoma.

A Granulosa Cell Tumor is a type of sex cord-stromal tumor, which are uncommon neoplasms that arise from the supporting cells of the ovary or testis. These tumors account for approximately 5% of all ovarian tumors and can occur at any age, but they are most commonly found in perimenopausal and postmenopausal women.

Granulosa cell tumors originate from the granulosa cells, which are normally responsible for producing estrogen and supporting the development of the egg within the ovarian follicle. These tumors can be functional, meaning they produce hormones, or nonfunctional. Functional granulosa cell tumors often secrete estrogen, leading to symptoms such as irregular menstrual periods, postmenopausal bleeding, and, in rare cases, the development of male characteristics (virilization) due to androgen production.

Granulosa cell tumors are typically slow-growing and can vary in size. They are often diagnosed at an early stage because they cause symptoms related to hormonal imbalances or, less commonly, due to abdominal pain or distention caused by the growing mass. The diagnosis is usually confirmed through imaging studies (such as ultrasound, CT, or MRI) and a biopsy or surgical removal of the tumor, followed by histopathological examination.

Treatment for granulosa cell tumors typically involves surgery to remove the tumor and, in some cases, adjacent organs if there is evidence of spread. The role of chemotherapy and radiation therapy is less clear, but they may be used in certain situations, such as advanced-stage disease or high-risk features. Regular follow-up with imaging studies and tumor marker measurements (such as inhibin) is essential due to the risk of recurrence, even many years after initial treatment.

Immunohistochemistry (IHC) is a technique used in pathology and laboratory medicine to identify specific proteins or antigens in tissue sections. It combines the principles of immunology and histology to detect the presence and location of these target molecules within cells and tissues. This technique utilizes antibodies that are specific to the protein or antigen of interest, which are then tagged with a detection system such as a chromogen or fluorophore. The stained tissue sections can be examined under a microscope, allowing for the visualization and analysis of the distribution and expression patterns of the target molecule in the context of the tissue architecture. Immunohistochemistry is widely used in diagnostic pathology to help identify various diseases, including cancer, infectious diseases, and immune-mediated disorders.

A Giant Cell Tumor (GCT) of bone is a relatively uncommon, locally aggressive tumor that can sometimes become malignant. It is characterized by the presence of multinucleated giant cells which are distributed throughout the tumor tissue. These giant cells are thought to be derived from osteoclasts, which are specialized cells responsible for bone resorption.

GCTs typically affect adults in their 20s and 30s, with a slight female predominance. The most common sites of involvement include the long bones near the knee (distal femur and proximal tibia), as well as the distal radius, sacrum, and spine.

The tumor usually presents as pain and swelling in the affected area, sometimes accompanied by restricted mobility or pathological fractures due to bone weakening. The diagnosis is typically made based on imaging studies (such as X-rays, CT scans, or MRI) and confirmed through a biopsy.

Treatment options for GCTs of bone may include intralesional curettage with or without the use of adjuvant therapies (like phenol, liquid nitrogen, or cement), radiation therapy, or surgical resection. In some cases, systemic treatments like denosumab, a monoclonal antibody targeting RANKL, may be used to control the growth and spread of the tumor. Regular follow-ups are essential to monitor for potential recurrence, which can occur in up to 50% of cases within five years after treatment.

I understand you are asking for a medical definition of "Horse Diseases." However, it's important to note that there isn't a specific medical field dedicated to horse diseases as we typically categorize medical fields by human diseases and conditions. Veterinary medicine is the field responsible for studying, diagnosing, and treating diseases in animals, including horses.

Here's a general definition of 'Horse Diseases':

Horse diseases are health issues or medical conditions that affect equine species, particularly horses. These diseases can be caused by various factors such as bacterial, viral, fungal, or parasitic infections; genetic predispositions; environmental factors; and metabolic disorders. Examples of horse diseases include Strangles (Streptococcus equi), Equine Influenza, Equine Herpesvirus, West Nile Virus, Rabies, Potomac Horse Fever, Lyme Disease, and internal or external parasites like worms and ticks. Additionally, horses can suffer from musculoskeletal disorders such as arthritis, laminitis, and various injuries. Regular veterinary care, preventative measures, and proper management are crucial for maintaining horse health and preventing diseases.

A meningioma is a type of slow-growing tumor that forms on the membranes (meninges) surrounding the brain and spinal cord. It's usually benign, meaning it doesn't spread to other parts of the body, but it can still cause serious problems if it grows and presses on nearby tissues.

Meningiomas most commonly occur in adults, and are more common in women than men. They can cause various symptoms depending on their location and size, including headaches, seizures, vision or hearing problems, memory loss, and changes in personality or behavior. In some cases, they may not cause any symptoms at all and are discovered only during imaging tests for other conditions.

Treatment options for meningiomas include monitoring with regular imaging scans, surgery to remove the tumor, and radiation therapy to shrink or kill the tumor cells. The best treatment approach depends on factors such as the size and location of the tumor, the patient's age and overall health, and their personal preferences.

Giant cell tumors (GCTs) are a type of benign or rarely malignant bone tumor that is characterized by the presence of multinucleated giant cells. These tumors typically affect adults between the ages of 20 and 40, and they can occur in any bone, but they most commonly involve the long bones near the knee joint.

GCTs are composed of three types of cells: mononuclear stromal cells, which produce the matrix of the tumor; multinucleated osteoclast-like giant cells, which resemble the bone-resorbing cells found in normal bone; and macrophages, which are part of the body's immune system.

The mononuclear stromal cells produce a variety of growth factors that stimulate the formation and activity of the osteoclast-like giant cells, leading to localized bone destruction. The tumor may cause pain, swelling, and limited mobility in the affected area.

While GCTs are typically benign, they can be aggressive and locally destructive, with a tendency to recur after surgical removal. In some cases, GCTs may undergo malignant transformation, leading to the development of sarcomas. Treatment options for GCTs include curettage (scraping out) of the tumor, followed by bone grafting or the use of a cement spacer to fill the defect, and/or adjuvant therapy with radiation or chemotherapy.

Neoplasms, germ cell and embryonal are types of tumors that originate from the abnormal growth of cells. Here's a brief medical definition for each:

1. Neoplasms: Neoplasms refer to abnormal tissue growths or masses, which can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled cell division and may invade surrounding tissues or spread to other parts of the body through a process called metastasis.
2. Germ Cell Tumors: These are rare tumors that develop from the germ cells, which give rise to sperm and eggs in the reproductive organs (ovaries and testes). They can be benign or malignant and may occur in both children and adults. Germ cell tumors can also arise outside of the reproductive organs, a condition known as extragonadal germ cell tumors.
3. Embryonal Tumors: These are a type of malignant neoplasm that primarily affects infants and young children. They develop from embryonic cells, which are immature cells present during fetal development. Embryonal tumors can occur in various organs, including the brain (medulloblastomas), nervous system (primitive neuroectodermal tumors or PNETs), and other areas like the kidneys and liver.

It is essential to note that these conditions require professional medical evaluation and treatment by healthcare professionals with expertise in oncology and related fields.

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Le BH, Boyer PJ, Lewis JE, Kapadia SB (July 2004). "Granular cell tumor: immunohistochemical assessment of inhibin-alpha, ... giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance ... However, in some cell types it is detectable only when up-regulated, such as activated but not quiescent microglia, and can ... O'Reilly D, Greaves DR (September 2007). "Cell-type-specific expression of the human CD68 gene is associated with changes in ...
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Granular cell tumor Glomus tumor Plexiform angiomyxoid myofibroblastic tumor Primary clear cell sarcoma This tumour was first ... The tumour is biphasic and contains spindle and epithelial cells. The spindle cells form diffuse sheets. The epithelial cells ... diagnosis include Multiple minute gastrointestinal stromal tumor Interstitial cell of Cajal hyperplasia Nerve sheath tumors ( ... Miettinen M, Dow N, Lasota J, Sobin LH (2009) A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young ...
Granular Cell Tumour is also a tumour arising from neural cells, though it was incorrectly thought to arise from muscle cells ... also known as Congenital Granular Cell Tumour (but not related to Granular Cell Tumour) occur mostly on the upper gum, the ... c) Giant Cell Epulis also known as Peripheral Giant Cell Granuloma, are like Fibrous Epulis and occur at the anterior ... The cells terminally differentiate as they migrate to the surface from the stratum basale where the progenitor cells are ...
The tumour compresses the surrounding parenchyma, producing a pseudocapsule. The most common cell type exhibited by renal cell ... containing both clear and granular cells. The recommended histologic grading schema for RCC is the Fuhrman system (1982), which ... Clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma with smooth muscle stroma Mucinous tubular and ... Multilocular cystic clear cell renal cell carcinoma Tubulocystic renal cell carcinoma Thyroid-like follicular renal cell ...
... granular cell tumor of the sellar region, and spindle cell oncocytoma 11.4 Pituitary adenoma/PitNET 11.5 Pituitary blastoma ... 9.1.2.4 T-cell and NK/T-cell lymphomas 9.2 Histiocytic tumors 9.2.1 Erdheim-Chester disease 9.2.2 Rosai-Dorfman disease 9.2.3 ... tumor 1.5.6 Rosette-forming glioneuronal tumor 1.5.7 Myxoid glioneuronal tumor 1.5.8 Diffuse leptomeningeal glioneuronal tumor ... 3 malignant tumour and /1 borderline tumour), and the WHO Grade (a parameter connected with the "aggressiveness" of the tumour ...
There are cystic spaces surrounded by two uniform rows of oncocytes, which are epithelial cells with abundant, granular, ... This Warthin's tumor presented as a parotid mass in a middle-aged male, who underwent superficial parotidectomy. The tumor, at ... Histopathology of Warthin tumor in the parotid gland. H&E stain. Histopathology of Warthin tumor in the parotid gland. Another ... Histopathology of Warthin tumor in the parotid gland. Higher magnification of a file "Warthin tumor (1).jpg". H&E stain. ...
... plasma-cell tumors, mast-cell tumors, the granular-cell tumors, cervical cancer and the common liver tumor of the mouse. ... She developed lines of a transplantable mast-cell tumor of a mouse, now known as "Dunn cells", used widely in laboratory ... Potter, Michael (2007). "The Early History of Plasma Cell Tumors in Mice, 1954-1976" in George F. Vande Woude and George Klein ... Stewart also mentions Dunn's discoveries the protein-secreting, plasma-cell tumors that originate in the ileocecal region of ...
PECs consist of perivascular epithelioid cells with a clear/granular cytoplasm and central round nucleus without prominent ... clear-cell sugar tumour (CCST), lymphangioleiomyomatosis, and, clear-cell myomelanocytic tumour of ligamentum teres/falciform ... Perivascular epithelioid cell tumour, also known as PEComa or PEC tumour, is a family of mesenchymal tumours consisting of ... Normally, no perivascular epitheloid cells exist; the name refers to the characteristics of the tumour when examined under the ...
Histomorphologically, the tumour resembles the cells of the pancreatic acini and, typically, have moderate granular cytoplasm ... Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. It ... Light microscopy of an acinar cell carcinoma biopsy typically shows granular appearance. Immunohistochemistry is usually ... Feb 2010). "[A case of acinar cell carcinoma of pancreas, manifested by subcutaneous nodule as initial clinical symptom]". ...
... solitary glomus tumor) Granular cell tumor (Abrikossoff's tumor, Abrikossov's tumor, granular cell myoblastoma, granular cell ... about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an ... Giant cell fibroblastoma Giant cell tumor of the tendon sheath (giant cell synovioma, localized nodular tenosynovitis, ... pale cell acanthoma) Clear cell squamous cell carcinoma (clear cell carcinoma of the skin) Chronic scar keratosis (chronic ...
This hypothesis was arrived at by taking miRNA expression profiles of GNP-like tumour cells from mouse mutants. There are ... It arises when cerebellar granule neurone progenitor (GNP) cells fail to properly migrate and differentiate. MB can be induced ... These totipotent cells represent the earliest stages of mammalian development (they are derived from the inner cells of the ... Mir-92 is no exception and currently identified gene targets have been among those involved in cell cycle regulation and cell ...
... granular cytoplasm. The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant. ... An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting ... An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing ... Kidney Renal cell carcinoma Hurthle cell Coburn V, Radfar A, Snook D, Mahalingam M (April 2007). "Cutaneous oncocytoma - a ...
... cerebellum neurons such as Cerebellum granule cell and Purkinje cells. Finally, it is expressed in multiple tumor cells for ... One frequent destination of tumor cells is the brain. So to settle in the brain, tumor cells have to succeed in crossing the ... This could explain why this protein gets suddenly overproduced in tumor cells. L1CAM's diverse functions make tumor cells more ... cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal ...
... and either non-solid tumor cells such as leukemia cells or normal cells. This test yielded promising results, as kalkitoxin ... Kalkitoxin induces delayed neuronal necrosis in cerebellar granule cells of the rat. This neuronal necrosis proved to be NMDA- ... and HCT-116 cells) as compared to the non-solid tumor and normal cell conditions. Kalkitoxin exerts this cytotoxic effect ... At concentrations comparable to those required for tumor-selective cytotoxicity, kalkitoxin induces cell death when applied to ...
The tumor is uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular ... whereas nongerminomatous germ-cell tumors display a variety of differentiation. Like other germ-cell tumors, germinomas can ... Nongerminomatous germ-cell tumors may be associated with increased markers such as alpha-fetoprotein with yolk sac tumors, as ... A germinoma is a type of germ-cell tumor, which is not differentiated upon examination. It may be benign or malignant. ...
WNT tumors originate from the lower rhombic lip of the brainstem, while SHH tumors originate from the external granular layer. ... Small-blue-round-cell tumors, Brain tumor, Pediatric cancers). ... The classic rosette with tumor cells around a central lumen can ... Using gene transfer of SV40 large T-antigen in neuronal precursor cells of rats, a brain tumor model was established. The PNETs ... Histologically, the tumor is solid, pink-gray in color, and is well circumscribed. The tumor is very cellular, with high ...
It is a description of how deeply tumor cells have invaded. Currently, the standard Breslow's depth has been replaced by the ... Breslow's depth is measured from the granular layer of the epidermis down to the deepest point of invasion (sometimes involving ... Tumor depth cannot be calculated from a shave biopsy that only contains a portion of the tumor because it leads to an ... Tumor depth is most accurately measured by evaluating the entire tumor via an excisional biopsy. Determination from specimens ...
... granular cell myoblastoma, granular cell nerve sheath tumor, and granular cell schwannoma. Granular cell tumors (GCTs) affect ... Vaginal granular cell tumors are generally rare. Breast granular cell tumors arise from intralobular breast stroma and occurs ... Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. It is ... Multiple granular cell tumors may seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene. These tumors, ...
A somewhat similar lesion, congenital epulis, occurs less frequently than the granular cell tumor and occurs on the alveolar ... Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. ... Malignant granular cell tumors are extremely uncommon, accounting for less than 2% of granular cell tumors. [24] Granular cell ... 26] However, congenital oral granular cell tumor has been reported in a neonate,27 and non-congenital granular cell tumor of ...
Beat cancer and the feeling of deteriorating health with New Hope Unlimiteds Alternative Treatments for Granular Cell Tumors. ... Malignant granular cell tumor (MGCT) is a high-grade mesenchymal tumor of Schwann cell origin. Mesenchymal tumors include ... The goal of our alternative treatments for granular cell tumors is to stimulate the spontaneous regression of cancer cells and ... Were you diagnosed with a malignant granular cell tumor? If yes, the next most important step to take is to plan your treatment ...
A somewhat similar lesion, congenital epulis, occurs less frequently than the granular cell tumor and occurs on the alveolar ... Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. ... Malignant granular cell tumors are extremely uncommon, accounting for less than 2% of granular cell tumors. [24] Granular cell ... 26] However, congenital oral granular cell tumor has been reported in a neonate,27 and non-congenital granular cell tumor of ...
Primitive non-neural granular cell tumour (PNGCT) is a rare tumour of uncertain lineage. This report describes a case of PGNCT ...
Breast, Schwann Cells, S100 Proteins Abstract. Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin ... Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group Authors. * Pakesh Baishya ... Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. Although rare, GCT of the breast should ... Pediatric Granular Cell Tumor of the Breast: An uncommon neoplasm in an uncommon site and age group. Autopsy and Case Reports, ...
A somewhat similar lesion, congenital epulis, occurs less frequently than the granular cell tumor and occurs on the alveolar ... Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. ... encoded search term (Oral Granular Cell Tumors) and Oral Granular Cell Tumors What to Read Next on Medscape ... The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a ...
"Granular Cell Tumor" by people in this website by year, and whether "Granular Cell Tumor" was a major or minor topic of these ... "Granular Cell Tumor" by people in Profiles.. * Pulmonary Granular Cell Tumors: A Study of 4 Cases Including a Malignant ... Cutaneous clear-cell granular cell tumors: the histologic description of an unusual variant. J Cutan Pathol. 2007 May; 34(5): ... "Granular Cell Tumor" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
A somewhat similar lesion, congenital epulis, occurs less frequently than the granular cell tumor and occurs on the alveolar ... Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. ... Malignant granular cell tumors are extremely uncommon, accounting for less than 2% of granular cell tumors. [2] Granular cell ... encoded search term (Oral Granular Cell Tumors) and Oral Granular Cell Tumors What to Read Next on Medscape ...
CURRA, Marina et al. Granular cell tumor: report of two cases. RPG, Rev. pós-grad. []. 2011, 18, 4, pp. 266-268. ISSN 0104-5695 ... The granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue. The sites most commonly affected are the dorsum ...
Diagnosis: Granular cell tumor Week 88: Case 3. Diagnosis: Granular cell tumor Week 34: Case 4. Diagnosis: Granular cell tumor ... Granular cell tumor Week 665: Case 1. Diagnosis: Granular cell tumor Week 659: Case 3. Diagnosis: breastGranular cell tumor ... Granular cell tumor Week 576: Case 1. Diagnosis: Granular cell tumor Week 443: Case 4. Diagnosis: Granular cell tumor Week 416 ... Granular cell tumor Week 372: Case 3. Diagnosis: Granular cell tumor Week 340: Case 1. Diagnosis: Granular cell tumor Week 315 ...
This case series of soft tissue granular cell tumors aimed to better characterize their histologic and clinical findings. ... Objectives Granular cell tumors are rare neoplasms of neural origin. Despite the mesenchymal nature of these tumors, they ... Granular cell tumors (GCTs) are rare lesions believed to be of neural origin.[1,2] They can occur in almost any location along ... Methods All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin ...
Ayres, B., Miller, N. R., Eberhart, C. G., & DiBernardo, C. W. (2009). Ultrasound features of orbital granular cell tumor. ... Ultrasound features of orbital granular cell tumor. / Ayres, Bernadete; Miller, Neil R.; Eberhart, Charles G. et al. In: ... Ayres, B, Miller, NR, Eberhart, CG & DiBernardo, CW 2009, Ultrasound features of orbital granular cell tumor, Ophthalmic ... Ultrasound features of orbital granular cell tumor. In: Ophthalmic plastic and reconstructive surgery. 2009 ; Vol. 25, No. 4. ...
Granular-cell tumor of the anterior abdominal wall. Lee J. McGhan, Nabil Wasif, Scott W. Young, Joseph M. Collins, Ann E. ... Dive into the research topics of Granular-cell tumor of the anterior abdominal wall. Together they form a unique fingerprint ...
keywords = "polypoid granular cell tumor, polypoid granular cell tumor",. author = "Francesco Ricci and Andrea Paradisi and { ... Primitive polypoid granular cell tumor. Insieme formano una fingerprint unica. * Cells Agricultural and Biological Sciences ... Primitive polypoid granular cell tumor. / Ricci, Francesco; Paradisi, Andrea; Lanza Silveri, Sara et al. In: European Journal ... Primitive polypoid granular cell tumor. European Journal of Dermatology. 2012;22:574-575. doi: 10.1684/ejd.2012.1768 ...
A granular cell tumor that arises from a peripheral nerve and is characterized by the absence of atypical or malignant ... Granular cell tumor*Benign granular cell tumor*Benign peripheral nerve granular cell tumor ... benign granular cell tumor of nerve; Benign Granular Cell Tumor of Peripheral Nerve; benign granular cell tumor of peripheral ... benign granular cell tumor of the peripheral nerve; benign granular cell tumour of nerve; benign granular cell tumour of ...
Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the ... Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review Jahan Abtahi, * E-Mail Address of Dr ... Keywords: Granular cell tumor, Orbit, Protein S-100, Inferior rectus muscle, Magnetic resonance imaging, Biopsy.. ... The tumor was resected through a retroseptal transconjunctival approach. The final histological examination revealed findings ...
Conclusion: Granular cell tumor is a rare tumor of the larynx and should be considered a differential diagnosis in all adult ... Cura, Melisa B., Labedz, Geraldine, Degli Uomini, Luciana and Palacios Huatuco, René M. (2022) Granular cell tumor of the vocal ... Introduction and importance: Granular cell tumors (GCT) are rare neoplasms. The most common places are the head and neck. The ... Granular cell tumor of the vocal cord: Case Report and Literature Review ...
Ortiz-Hidalgo, C., de la Vega, G., & Moreno-Collado, C. (1997). Granular cell tumor (Abrikossoff tumor) of the clitoris. ...
We have recently shown that in human granule precursor tumour cells a fall in extracellular pH triggers increases in ... We now find that differentiation of granule precursor tumour cells profoundly affects their ability to respond to extracellular ... Hence, the ability of human granule cells to respond to extracellular acidification by generating Ca(2+) signals and ERK ... Differentiating cells have a lower Ca(2+) release probability from intracellular Ca(2+) stores upon acidification and cells ...
Granular cell tumor 2nd. Deep mucosa. Hypo. Round. Homogenous, fine margins. Inflammatory fibroid polyp 2nd. Deep mucosa. Hypo ... Table 1 Endoscopic ultrasonography features of subepithelial tumors Subepithelial tumor. Endoscopic ultrasound layer. ... Neuroendocrine tumor (carcinoid) 2nd. Deep mucosa. Hypo or iso. Round, sessile or polypoid. Erythematous depression or ... Gastrointestinal stromal tumor 4th. Muscularis propria. Hypo. Irregular or round. Heterogenous, marginal halo, cystic spaces, ...
Spinal intradural extramedullary granular cell tumor. Farhat L, Hodroj MH, Kawtharani S, Moussalem C, Annan TE, Assi H, Darwish ... Novel strategies to prevent and overcome relapse after allogeneic hematopoietic cell transplantation in acute lymphoblastic ...
Differential diagnoses include carcinoma, granular cell tumor of the larynx, and sarcoid. ...
Bridging the histologic features between pituicytoma and granular cell tumor is the spindle cell oncocytoma, a tumor that is ... The TTF1-Associated Family of Sellar Tumors. Pituicytoma, granular cell tumor, and spindle cell oncocytoma exhibit overlapping ... TTF1-associated pituitary tumors include pituicytoma, granular cell tumor, and spindle cell oncocytoma. ... Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Am J Surg Pathol. 2013;37:1694- ...
Moreover, CE does not represent a variant of granular cell tumors.7 It differs from other granular cell tumors in adults by its ... Congenital epulis also called congenital granular cell tumour of the newborn is a rare benign gingival cell tumor that most ... It is a congenital granular cell lesion (CGCL) having a close resemblance to granular cell myeloblastoma. The word "epulis" ... C.E. only occurs on the gum pads of neonates while granular cell tumors can occur any where in the body and at any age. ...
Malignant Granular Cell Tumor; Multiple Myeloma; Non-Hodgkin s Lymphoma; Parkinsons Disease; Prostate Cancer and Respiratory ... Now the ear, nose and throat guy says that the MRI for the tumor in my brain didnt find the tumor where they thought it was ... B Cell Leukemia s,such as hairy Cell Leukemia. Parkinsons disease. Ischemic Heart Disease. ... Then basal cell skin cancers appeared. They eventually turned into squamous cell skin cancers that were removed leaving deep ...
Cytopathology of Oncocytic Carcinoid Tumor of the Lung Mimicking Granular Cell Tumor: A Case Report Subject Area: Pathology and ... View articletitled, Cytopathology of Oncocytic Carcinoid Tumor of the Lung Mimicking Granular Cell Tumor,span class=subtitle- ... Cystic Degeneration in Phyllodes Tumor: A Source of Error in Cytologic Interpretation Subject Area: Pathology and Cell Biology ... Circulating Cancer Cells in Peripheral Blood: A Case Report Subject Area: Pathology and Cell Biology ...
Granular cell tumors of the tongue: fibroma or schwannoma. Head Face Med. 2018 Jan 03; 14(1):1. ... PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells ... The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium ... Cell and Tissue Display: An Alternative Multipurpose Tool for Microscopy. J Histochem Cytochem. 2016 07; 64(7):403-11. ...
Granular cell tumor of the tongue (Abrikossoffs tumor). A case report and review of the literature ...
Granular cell tumors (GCTs). Human studies. GCTs are uncommon tumors. They are believed to be of neuronal origin (57). They are ... soft tissue tumors, which are thought to be derived from Schwann cells (58). The immunoprofile of granular cell tumors has ... increased incidence of malignant or non-malignant granular cell tumors in the meninges, likely derived from Schwann cells, ... Rejas RA, Campos MS, Cortes AR, Pinto DD and de Sousa SC: The neural histogenetic origin of the oral granular cell tumor: An ...
  • Eleven (21.6%) cases showed evidence of cytologic atypia and fulfilled the criteria for a diagnosis of atypical giant cell tumor. (medscape.com)
  • Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor. (opendentistryjournal.com)
  • Conclusion: Granular cell tumor is a rare tumor of the larynx and should be considered a differential diagnosis in all adult men with long-standing dysphonia. (ucc.edu.ar)
  • The diagnosis of pituitary adenoma is usually straightforward on H&E stained sections, which readily identify the monomorphic adenoma cell population. (cap.org)
  • Reporting more detailed histologic data can help clarify the biology of this tumor and aid in its histopathologic diagnosis. (thejcdp.com)
  • Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
  • Hemoptysis, while uncommon, more often occurs with a squamous cell carcinoma and can potentially lead to earlier diagnosis, whereas wheezing or stridor occurs more often with the adenoid cystic variant. (msdmanuals.com)
  • These tumors, on occasion, may appear similar to neoplasms of renal (relating to the kidneys) origin or other soft tissue neoplasms. (wikipedia.org)
  • Objectives Granular cell tumors are rare neoplasms of neural origin. (medscape.com)
  • Introduction and importance: Granular cell tumors (GCT) are rare neoplasms. (ucc.edu.ar)
  • Odontogenic tumors, including odontogenic myxomas (OMs) are regarded as rare neoplasms in the human body. (thejcdp.com)
  • These lesions characteristically consist of polygonal cells with bland nuclei, abundant cytoplasm and fine eosinophilic cytoplasmic granules. (wikipedia.org)
  • Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. (medscape.com)
  • Granular cell tumors are slow-growing lesions (0.5-1 mm per year) that are neither painful nor tender. (medscape.com)
  • For many years, these lesions were referred to as granular cell myoblastoma. (medscape.com)
  • We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. (medscape.com)
  • Granular cell tumors (GCTs) are rare lesions believed to be of neural origin. (medscape.com)
  • Odontogenic tumors and allied lesions. (thejcdp.com)
  • Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
  • In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
  • A review of the literature reveals only a few reports of this tumor, and there has been scanty discussion of the imaging findings of posterior pituitary astrocytomas compared with lesions of the anterior pituitary gland. (ajnr.org)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • The granular cell tumor is characterized by the presence of sheets or clusters of plump, polygonal cells with a granular cytoplasm. (medscape.com)
  • Congenital epulis also contains sheets and/or clusters of plump cells with a granular cytoplasm and rounded or oval nuclei. (medscape.com)
  • Histopathologic evaluation showed sheets and nests of cells with abundant eosinophilic and granular cytoplasm in a uniform distribution throughout the lesion. (johnshopkins.edu)
  • There were foci of eosinophilia, stellate cytoplasm, and occasional gemistocytic morphology, and many cells were positive for glial fibrillary acidic protein (GFAP). (ajnr.org)
  • The tumor cells have abundant pale eosinophilic or amphophilic granular or vacuolated cytoplasm. (webpathology.com)
  • These cells generally are uniform and do not exhibit significant atypical features. (medscape.com)
  • Conclusions Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. (medscape.com)
  • A granular cell tumor that arises from a peripheral nerve and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. (beds.ac.uk)
  • atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
  • It is also known as Abrikossoff's tumor, granular cell myoblastoma, granular cell nerve sheath tumor, and granular cell schwannoma. (wikipedia.org)
  • Granular cell tumors of the tongue: fibroma or schwannoma. (harvard.edu)
  • A statistically significant increased risk for ipsilateral use of mobile phones, the same side of the brain as the phone was used, was published for malignant brain tumors ( 4 ) and vestibular schwannoma ( 5 ). (spandidos-publications.com)
  • Caltabiano R, Cappellani A, Di Vita M, Lanzafame S. The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (medscape.com)
  • When it develops beneath the epidermis or mucous membrane, it can lead to proliferation of the squamous cells and mimic squamous cell carcinoma. (uchicago.edu)
  • [ 2 ] Granular cell tumor with an overlying squamous cell carcinoma has been reported. (medscape.com)
  • Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
  • Other forms of cancer that can cause a bump in the tongue include squamous cell carcinoma, mast cell tumor and a granular cell tumor. (petcarerx.com)
  • Squamous cell carcinomas tend to metastasize to regional lymph nodes and directly invade mediastinal structures, leading to high local and regional recurrence rates. (msdmanuals.com)
  • Breast granular cell tumors arise from intralobular breast stroma and occurs within the distribution of the cutaneous branches of the supraclavicular nerve. (wikipedia.org)
  • List of cutaneous conditions Glassy cell carcinoma Rapini, Ronald P. (wikipedia.org)
  • Childhood cutaneous Abrikossoff tumor]. (medscape.com)
  • Cutaneous clear-cell granular cell tumors: the histologic description of an unusual variant. (uchicago.edu)
  • Granular cell tumors (GCTs) affect females more often than males. (wikipedia.org)
  • GCTs of the soft tissue are rare and not well characterized, representing only 0.5% of all soft tissue tumors. (medscape.com)
  • Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. (opendentistryjournal.com)
  • Malignant granular cell tumor (MGCT) is a high-grade mesenchymal tumor of Schwann cell origin. (newhopemedicalcenter.com)
  • Mesenchymal tumors include structures arising from mesodermal-derived precursor cells that develop into cartilage, bone, or other connective tissues. (newhopemedicalcenter.com)
  • Despite the mesenchymal nature of these tumors, they rarely occur in the soft tissue, and as a result, this subset is not well characterized. (medscape.com)
  • Tumors of the soft tissues composed of large eosinophilic cells. (beds.ac.uk)
  • In 1926, Abrikossoff first described granular cell tumors. (medscape.com)
  • Granular cell tumor (Abrikossoff tumor) of the clitoris. (lvhn.org)
  • Granular cell tumors are derived from neural tissue, as can be demonstrated by immunohistochemistry and ultrastructural evidence using electron microscopy. (wikipedia.org)
  • Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (wikipedia.org)
  • Granular cell tumor (GCT) is a rare soft tissue neoplasm of Schwann cell origin. (usp.br)
  • The granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue. (bvsalud.org)
  • Methods All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings. (medscape.com)
  • Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts. (medscape.com)
  • The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. (harvard.edu)
  • Cell and Tissue Display: An Alternative Multipurpose Tool for Microscopy. (harvard.edu)
  • A non-cancerous (benign) soft tissue tumour is a growth that does not spread (metastasize) to other parts of the body. (cancer.ca)
  • They are grouped by the type of soft tissue where the tumour started. (cancer.ca)
  • Lipoma is the most common type of non-cancerous soft tissue tumour. (cancer.ca)
  • Desmoid-type fibromatosis is a soft tissue tumour that is usually non-cancerous. (cancer.ca)
  • Hemangioma is a common non-cancerous soft tissue tumour caused by an abnormal buildup of blood vessels. (cancer.ca)
  • Soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. (dana-farber.org)
  • It starts in bone cells that make new bone tissue. (dana-farber.org)
  • Ewing tumors are most common in bone but can also form in soft tissue. (dana-farber.org)
  • Betatrophin is a newly characterized circulating hormone that is produced in tissue such as for example adipose tissues and liver organ and stimulates pancreatic beta-cell proliferation. (acancerjourney.info)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
  • Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)
  • There is also a cancerous type of glomus tumour called malignant glomus tumour. (cancer.ca)
  • Malignant granular cell tumors are extremely uncommon, accounting for less than 2% of granular cell tumors. (medscape.com)
  • Oral granular cell tumor is too uncommon to accurately assess an incidence rate. (medscape.com)
  • Oral granular cell tumors: a clinicopathologic and immunocytochemical study. (medscape.com)
  • Freitas VS, dos Santos JN, Oliveira MC, Santos PP, Freitas Rde A, de Souza LB. Intraoral granular cell tumors: clinicopathologic and immunohistochemical study. (medscape.com)
  • Primitive non-neural granular cell tumour (PNGCT) is a rare tumour of uncertain lineage. (bmj.com)
  • Myxoma, the tumor of primitive mesenchyme. (thejcdp.com)
  • Benign granular cell tumors have a recurrence rate of 2% to 8% when resection margins are deemed clear of tumor infiltration. (wikipedia.org)
  • While extensive surgery is not indicated, recurrence of granular cell tumors has been reported several years after removal. (medscape.com)
  • A third transcription factor, pituitary cell-restricted T box factor (Tpit), drives corticotroph adenomas but its antibody is not yet commercially available as an IHC marker. (cap.org)
  • The majority of previously classified "null cell" adenomas - negative for all hormonal markers - are now recognized as SF1 - driven and therefore would be classified as gonadotroph adenomas. (cap.org)
  • Pleomorphic adenomas and granular cell and benign cartilaginous tumors also occur. (msdmanuals.com)
  • Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models. (utsouthwestern.edu)
  • Pseudoepitheliomatous hyperplasia, a frequent finding in granular cell tumors, generally is not present over the congenital epulis. (medscape.com)
  • A somewhat similar lesion, congenital epulis, occurs less frequently than the granular cell tumor and occurs on the alveolar ridge of newborns. (medscape.com)
  • Treatment for granular cell tumors and congenital epulis is surgery. (medscape.com)
  • however, congenital epulis is negative for S-100 and other markers found in the granular cell tumor. (medscape.com)
  • Congenital epulis (CE) is a rare benign tumor that arises from the gum pads of neonates especially on the anterior maxillary regions and in females. (ispub.com)
  • Congenital epulis also called congenital granular cell tumour of the newborn is a rare benign gingival cell tumor that most commonly occurs along the anterior alveolar ridges of a neonate. (ispub.com)
  • Congenital epulis (CE) is a rare benign gingival tumor that occurs on the gum pads of a neonate. (ispub.com)
  • The etiology of oral granular cell tumors is unknown. (medscape.com)
  • Etiology Human papillomavirus (HPV) infects epithelial cells. (msdmanuals.com)
  • Malignant granular cell tumors, which fortunately are rare, may have a very benign histologic appearance. (medscape.com)
  • Histologic evaluation of the excised breast mass revealed a benign granular cell tumor. (usp.br)
  • Vered M, Carpenter WM, Buchner A. Granular cell tumor of the oral cavity: updated immunohistochemical profile. (medscape.com)
  • Granular-cell tumours: an immunohistochemical study. (medscape.com)
  • Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (medscape.com)
  • PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells. (harvard.edu)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • Granular Cell Tumor of the Orbit: Review of the Literature and a Proposed Treatment Modality. (beds.ac.uk)
  • Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue 40% of the time. (wikipedia.org)
  • Clinical photograph of a granular cell tumor on the tongue of a 38-year-old man. (medscape.com)
  • Approximately 70% of oral granular cell tumors occur in the tongue. (medscape.com)
  • GCT is usually a slow-growing, painless tumor involving the skin and soft tissues that is mostly located in the head and neck region, especially the tongue. (usp.br)
  • Granular cell tumor of the tongue in a 6-year-old girl--a case report. (medscape.com)
  • Dive A, Dhobley A, Fande PZ, Dixit S. Granular cell tumor of the tongue: Report of a case. (medscape.com)
  • Granular cell tumor of the tongue (Abrikossoff's tumor). (minervamedica.it)
  • was described our hospital for even more administration of tumor that was diagnosed, histopathologically, simply because low quality glioma. (acancerjourney.info)
  • Our study group has since the end of the 1990s published results from case-control studies on use of wireless phones and brain tumor risk ( 3 ). (spandidos-publications.com)
  • Pediatric Brain Tumor Cancer Stem Cells: Cell Cycle Dynamics, DNA Repair, and Etoposide Extrusion. (worthington-biochem.com)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • may give rise to cancer cell growth within the dut, known as ductal carcinoma in situ (DCIS). (brainscape.com)
  • Secretory carcinoma of the breast is a rare tumor that was initially described in children but the majority of cases have been reported in adults. (webpathology.com)
  • Secretory carcinoma of breast may be related to acinic cell carcinoma of salivary glands . (webpathology.com)
  • The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Granular cell tumors occur more commonly in blacks than in whites. (medscape.com)
  • Granular cell tumors occur twice as frequently in females than in males. (medscape.com)
  • Treatment of benign esophageal tumors by endoscopic techniques. (uchicago.edu)
  • Unlike traditional breast cancers, granular cell tumors are mostly found in the upper inner quadrant of the breast. (wikipedia.org)
  • Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. (researchgate.net)
  • The airway can be affected by primary tracheobronchial tumors, primary tumors that are adjacent to and invade or compress the airway, or cancers that metastasize to the airway. (msdmanuals.com)
  • In cases where the patient comes to surgery after long-term dopamine agonist therapy, stromal fibrosis and cytoplasmic shrinkage causing the cells to resemble lymphocytes may be evident. (cap.org)
  • Natural killer cells are large granular lymphocytes capable of killing tumor cells and certain virally infected cells in a manner not restricted by the major histocompatibility complex (MHC). (lu.se)
  • An orbitotomy with complete excision of the tumor was performed. (johnshopkins.edu)
  • It is a relatively indolent tumor with an excellent overall prognosis . (webpathology.com)
  • Primary airway tumors should be treated definitively with surgical resection if possible. (msdmanuals.com)
  • Vaginal granular cell tumors are generally rare. (wikipedia.org)
  • Malignancy is rare and constitutes only 2% of all granular cell tumors. (wikipedia.org)
  • The authors report the echographic characteristics of a rare orbital granular cell tumor and correlate these findings with histopathology. (johnshopkins.edu)
  • 1 2 3 4 5 The tumor is very rare and was described for the first time by Neumann in 1871and so is also called Neumann's tumor. (ispub.com)
  • Summary: Astrocytoma, or pituicytoma, of the posterior pituitary is a relatively rare entity consisting of poorly characterized glial tumor cells. (ajnr.org)
  • Elastofibroma is a rare non-cancerous tumour that grows slowly. (cancer.ca)
  • Rhabdomyoma is a rare non-cancerous tumour that starts in skeletal muscle. (cancer.ca)
  • Primary tracheal tumors are rare. (msdmanuals.com)
  • Microscopically, section shows spindle cell proliferation. (omicsonline.org)
  • Granular cell tumor of uncertain malignant potential. (uchicago.edu)
  • Both malignant and benign versions of the tumor exist, where malignant tumors are characterized histologically by features such as spindling, high nuclear to cytoplasmic ratios, pleomorphism, and necrosis. (wikipedia.org)
  • Granular cell tumors are typically solitary and rarely larger than three centimeters. (wikipedia.org)
  • The patient underwent a second TSS, and histology of the specimen revealed neoplastic proliferation of astrocytes and spindle-shaped cells with fascicles. (ajnr.org)
  • The head and neck region accounts for approximately 45-65% of all sites for granular cell tumors. (medscape.com)
  • Unusual tumor affecting any site of the body, but most often encountered in the head and neck. (uchicago.edu)
  • Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification. (beds.ac.uk)
  • Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells. (ox.ac.uk)
  • We have recently shown that in human granule precursor tumour cells a fall in extracellular pH triggers increases in intracellular Ca(2+) concentration through activation of G-protein coupled proton-sensing receptors coupling to phospholipase C. This pH-dependent rise in cytosolic Ca(2+) led to activation of the extracellular signal-regulated kinase ERK, providing a mechanistic explanation of how extracellular acidification can promote tumour growth. (ox.ac.uk)
  • We now find that differentiation of granule precursor tumour cells profoundly affects their ability to respond to extracellular acidification with gene transcription. (ox.ac.uk)
  • Most primary airway tumors are not resectable because of metastasis, locally advanced stage, or patient comorbidities. (msdmanuals.com)
  • Granular cell tumors now generally are accepted as being of neural origin, either Schwann cell or neuroendocrine. (medscape.com)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • A similar molecular genetic abnormality has been found in both tumors - a recurrent balanced chromosomal translocation, t(12;15)(p13;q25) , which leads to the formation of ETV6-NTRK3 fusion gene. (webpathology.com)
  • However, proliferative growth and development of an ulcer indicates likely malignancy as this type of tumor can be either benign or malignant. (wikipedia.org)
  • Malignancy is limited to approximately 1-2% of all granular cell tumors. (medscape.com)