Heinz Bodies
Phenylhydrazines
Anemia, Hemolytic
Hemoglobins, Abnormal
Methemoglobin
Methemoglobinemia
Erythrocyte Deformability
Chromium Isotopes
Iron Isotopes
Erythrocytes
The kinetics of hematopoiesis in the light horse III. The hematological response to hemolytic anemia. (1/50)
The hematological response to acetylphenylhydrazine hemolytic anemia was studied in three standardbred horses. The lifespan of erythrocytes produced during the most severe phase of the anemia were measured with 75-selenomethionine and found to be 144 days as compared to the 139 day lifespan in response to hemorrhagic anemia or 155 days in normal standardbred horses measured previously using the same technique. The erythrocyte counts returned to initial values in 42 days (37, 34 and 54 days) a mean erythrocyte production of 6.4 times 10-12 erythrocytes/day. The mean hemoglobin production was 0.31 gm/kg body weight/day as compared to 0.11 gm Hb/kg/day previously observed in response to hemorrhagic anemia. The mean increase in erythrocyte mean cell volume was 12 mu-3 during the acute response phase to hemolytic anemia in contrast to the absence of a significant increase in the mean cell volume as previously observed during response to hemorrhagic anemia. Free Heinz bodies separated from erythrocytes during the acute phase could not be differentiated from platelets on the hemocytometer counting chamber with standard techniques. (+info)Hematological effects in F344 rats and B6C3F1 mice during the 13-week gavage toxicity study of methylene blue trihydrate. (2/50)
Methylene blue trihydrate is used widely as a dye and therapeutic agent. Methylene blue was administered by gavage to 30 animals/sex/dose group in a 0.5% aqueous methylcellulose suspension at doses of 0, 25, 50, 100, and 200 mg/kg. Blood samples from 10 animals/sex/dose group were collected at the end of study weeks 1, 6, and 13. Methylene blue treatment resulted in methemoglobin formation and oxidative damage to red blood cells, leading to a regenerative anemia and a variety of tissue and biochemical changes secondary to erythrocyte injury. An early change was a dose-related increase in methemoglobin, where the response of rats and mice was similar in magnitude. Mice appeared to be more sensitive than rats to the formation of Heinz bodies and the development of anemia that was characterized by a decrease in hemoglobin, hematocrit, and erythrocyte count. Splenomegaly was apparent in all treated mice and in the 100 mg/kg (males only) and 200 mg/kg rats at necropsy. There was a dose-related increase in absolute and relative spleen weight for both species. Microscopic examination revealed increased splenic hematopoiesis in all mice treatment groups and in rats at the 50 mg/kg dose level and above. Splenic congestion and bone marrow hyperplasia were also observed in these rat-dose groups. Mice at the higher doses showed hematopoiesis in the liver and accumulation of hemosiderin in Kupffer cells. These gross and microscopic findings are consistent with the development of hemolytic anemia. A dose-related increase in the reticulocyte count during study weeks 6 and 13 suggested a compensatory response to anemia. (+info)Abnormal erythrocyte metabolism in hepatic disease. (3/50)
Erythrocyte (RBC) metabolic studies were done on 114 patients with severe hepatic disease. Heinz body formation after incubation of RBCs with acetyl phenylhydrazine was found to be significantly higher in patients than in controls. RBC-reduced glutathione levels were lower than those of controls both before and after incubation with acetyl phenylhydrazine, and patients with the highest Heinz body counts had the lowest reduced glutathione levels. RBC methylene blue-stimulated hexose monophosphate (HMP) shunt metabolism and glucose recycling through the shunt were significantly lower in patients with active hepatic disease than in controls. There was no difference in resting HMP shunt activity or in resting recycling of glucose. Despite impairment of shunt metabolism, total glucose consumption was greater in patients than in controls. The patients with the lowest stimulated HMP shunt metabolism and glucose recycling had the highest Heinz body counts, lowest reduced glutathione, and highest total glucose consumption. A continuum of abnormal shunt metabolism was seen, from a mild reduction of stimulated HMP shunt activity to a severe combined decrease in both the HMP shunt and glucose recycling. When measured, glutathione reductase, glutathione peroxidase, glucose-6-phosphate dehydrogenase, and transketolase were normal or increased. Sequential studies were done on 11 patients who had abnormal metabolic studies. Coincident with improvement of HMP shunt metabolism, the Heinz body counts became lower, reduced glutathione higher, hematocrit higher, and liver function improved. Impaired HMP shunt metabolism appears to be a common, acquired RBC abnormality in patients with severe, active liver disease. (+info)Comparative gavage subchronic toxicity studies of o-chloroaniline and m-chloroaniline in F344 rats and B6C3F1 mice. (4/50)
ortho-Chloroaniline (o-CA) andmeta-chloroaniline (m-CA) are chemical intermediates for pigment production in the textile industry. Comparative subchronic gavage studies were conducted to determine the effect of structure on toxicity.o-CA orm-CA was administered to 10 animals/sex/species in deionized water at dosages of 0, 10, 20, 40, 80, and 160 mg/kg for 13 weeks. Blood samples for clinical pathology were collected after 3 and 23 days in rats and at study termination (Day 93) in rats and mice. No mortalities occurred that could be directly attributed to treatment. Transient clinical signs of toxicity observed after dosing included cyanosis in rats and ataxia and tremors in mice. Methemoglobin formation was directly related to dosage (rats and mice) and duration of treatment (rats). At study termination, Heinz body formation in erythrocytes in association with decreased hemoglobin, hematocrit, and red blood cell count was a prominent treatment-related effect. Enlarged spleens (gross necropsy observation) and increased spleen weight were treatment effects of each chemical in both species. Microscopic lesions typical of increased red blood cell production were found in hematopoietic tissues (bone marrow, spleen, and liver), while lesions due to increased red cell destruction were found in these tissues and also the kidneys (rats). Microscopic changes were more frequently seen and severe, and involved more body organs, in rats than mice, and in m-CA-treated animals thano-CA-treated animals. Sex differences in lesion incidence/severity were not evident. (+info)Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. (5/50)
Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions, including cell proliferation and differentiation and protection of specific proteins from oxidative damage. However, the physiological roles of the peroxiredoxins have not been determined. To clarify the physiological relevance of this protein type, we generated a mouse model deficient in Prx II, which is abundantly expressed in all types of cells. The Prx II-/- mice were healthy in appearance and fertile. However, they had splenomegaly caused by the congestion of red pulp with hemosiderin accumulation. Heinz bodies were detected in their peripheral blood, and morphologically abnormal cells were elevated in the dense red blood cell (RBC) fractions, which contained markedly higher levels of reactive oxygen species (ROS). The Prx II-/- mice had significantly decreased hematocrit levels, but increased reticulocyte counts and erythropoietin levels, indicative of a compensatory action to maintain hematologic homeostasis in the mice. In addition, a labeling experiment with the thiol-modifying reagent biotinylated iodoacetamide (BIAM) in Prx II-/- mice revealed that a variety of RBC proteins were highly oxidized. Our results suggest that Prx II-/- mice have hemolytic anemia and that Prx II plays a major role in protecting RBCs from oxidative stress in mice. (+info)Isolation and identification of sodium 2-propenyl thiosulfate from boiled garlic (Allium sativum) that oxidizes canine erythrocytes. (6/50)
Sodium 2-propenyl thiosulfate was identified in boiled garlic (Allium sativum). When canine erythrocytes were incubated with sodium 2-propenyl thiosulfate, the methemoglobin concentration and Heinz body percentage in erythrocytes were both increased, indicating that the compound induced oxidative damage in canine erythrocytes. It seems that this compound is one of the causative agents of garlic-induced hemolysis in dogs. (+info)Formation of meso, N-diphenylprotoporphyrin IX by an aerobic reaction of phenylhydrazine with oxyhemoglobins. (7/50)
Administration of phenylhydrazine to rabbits resulted in the denaturation of hemoglobins in erythrocytes, causing the formation of intracellular precipitates known as Heinz bodies, severe hemolytic anemia, and reticulocytosis. To elucidate the molecular mechanism of the destabilization, we allowed human oxyhemoglobins to react aerobically with phenylhydrazine. After treatment with acetic acid/HCl and H2SO4/methanol, the chloroform extract contained blue-green pigments of major products accompanied by different minor products. Each product was isolated by column chromatography. By fast-atom-bombardment mass spectrometry (FAB-MS) and proton nuclear magnetic resonance (1H-NMR) spectrometry, dimethyl esters of N-phenylprotoporphyrin IX and meso, N-diphenylprotoporphyrin IX were determined. Other major products also were determined to be dimethyl esters of triphenyl-and tetraphenyl-substituted protoporphyrins by FAB-MS. The formation of meso, N-diphenylprotoporphyrin indicated that the addition of a phenyl radical to the meso-carbon atom of the protoporphyrin ring occurred. Triphenyl and tetraphenyl adducts also indicated the formation of phenyl radicals in the aerobic reaction of phenylhydrazine with oxyhemoglobins. From these results, we suggest that the formation of phenyl radicals and the replacement of heme with phenyl-substituted protoporphyrins cause the destabilization of hemoglobins to induce Heinz bodies and hemolytic anemia with phenylhydrazine. (+info)Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia. (8/50)
Hemoglobin (Hb) A production during red blood cell development is coordinated to minimize the deleterious effects of free alpha- and beta-Hb subunits, which are unstable and cytotoxic. The alpha-Hb-stabilizing protein (AHSP) is an erythroid protein that specifically binds alpha-Hb and prevents its precipitation in vitro, which suggests that it may function to limit free alpha-Hb toxicities in vivo. We investigated this possibility through gene ablation and biochemical studies. AHSP(-/-) erythrocytes contained hemoglobin precipitates and were short-lived. In hematopoietic tissues, erythroid precursors were elevated in number but exhibited increased apoptosis. Consistent with unstable alpha-Hb, AHSP(-/-) erythrocytes contained increased ROS and evidence of oxidative damage. Moreover, purified recombinant AHSP inhibited ROS production by alpha-Hb in solution. Finally, loss of AHSP worsened the phenotype of beta-thalassemia, a common inherited anemia characterized by excess free alpha-Hb. Together, the data support a model in which AHSP binds alpha-Hb transiently to stabilize its conformation and render it biochemically inert prior to Hb A assembly. This function is essential for normal erythropoiesis and, to a greater extent, in beta-thalassemia. Our findings raise the possibility that altered AHSP expression levels could modulate the severity of beta-thalassemia in humans. (+info)Heinz bodies are small, irregularly shaped inclusions found in the red blood cells (RBCs). They are aggregates of denatured hemoglobin and are typically seen in RBCs that have been exposed to oxidative stress. This can occur due to various factors such as exposure to certain chemicals, drugs, or diseases.
The presence of Heinz bodies can lead to the premature destruction of RBCs, a condition known as hemolysis. This can result in anemia and related symptoms such as fatigue, weakness, and shortness of breath. It's important to note that while Heinz bodies are often associated with certain diseases, they can also be present in otherwise healthy individuals who have been exposed to oxidative stress.
It's worth mentioning that the term "Heinz bodies" comes from the name of the scientist Robert Heinz, who first described them in 1890.
Phenylhydrazines are organic compounds that contain a phenyl group (a benzene ring with a hydrogen atom substituted by a hydroxy group) and a hydrazine group (-NH-NH2). They are aromatic amines that have been used in various chemical reactions, including the formation of azos and hydrazones. In medicine, phenylhydrazines were once used as vasodilators to treat angina pectoris, but their use has largely been discontinued due to their toxicity and potential carcinogenicity.
Hemolytic anemia, congenital is a type of anemia that is present at birth and characterized by the abnormal breakdown (hemolysis) of red blood cells. This can occur due to various genetic defects that affect the structure or function of the red blood cells, making them more susceptible to damage and destruction.
There are several types of congenital hemolytic anemias, including:
1. Congenital spherocytosis: A condition caused by mutations in genes that affect the shape and stability of red blood cells, leading to the formation of abnormally shaped and fragile cells that are prone to hemolysis.
2. G6PD deficiency: A genetic disorder that affects the enzyme glucose-6-phosphate dehydrogenase (G6PD), which is essential for protecting red blood cells from damage. People with this condition have low levels of G6PD, making their red blood cells more susceptible to hemolysis when exposed to certain triggers such as infections or certain medications.
3. Hereditary elliptocytosis: A condition caused by mutations in genes that affect the structure and flexibility of red blood cells, leading to the formation of abnormally shaped and fragile cells that are prone to hemolysis.
4. Pyruvate kinase deficiency: A rare genetic disorder that affects an enzyme called pyruvate kinase, which is essential for the production of energy in red blood cells. People with this condition have low levels of pyruvate kinase, leading to the formation of fragile and abnormally shaped red blood cells that are prone to hemolysis.
Symptoms of congenital hemolytic anemia can vary depending on the severity of the condition but may include fatigue, weakness, pale skin, jaundice, dark urine, and an enlarged spleen. Treatment may involve blood transfusions, medications to manage symptoms, and in some cases, surgery to remove the spleen.
Hemolytic anemia is a type of anemia that occurs when red blood cells are destroyed (hemolysis) faster than they can be produced. Red blood cells are essential for carrying oxygen throughout the body. When they are destroyed, hemoglobin and other cellular components are released into the bloodstream, which can lead to complications such as kidney damage and gallstones.
Hemolytic anemia can be inherited or acquired. Inherited forms of the condition may result from genetic defects that affect the structure or function of red blood cells. Acquired forms of hemolytic anemia can be caused by various factors, including infections, medications, autoimmune disorders, and certain medical conditions such as cancer or blood disorders.
Symptoms of hemolytic anemia may include fatigue, weakness, shortness of breath, pale skin, jaundice (yellowing of the skin and eyes), dark urine, and a rapid heartbeat. Treatment for hemolytic anemia depends on the underlying cause and may include medications, blood transfusions, or surgery.
Abnormal hemoglobins refer to variants of the oxygen-carrying protein found in red blood cells, which differ from the normal adult hemoglobin (HbA) in terms of their structure and function. These variations can result from genetic mutations that affect the composition of the globin chains in the hemoglobin molecule. Some abnormal hemoglobins are clinically insignificant, while others can lead to various medical conditions such as hemolytic anemia, thalassemia, or sickle cell disease. Examples of abnormal hemoglobins include HbS (associated with sickle cell anemia), HbC, HbE, and HbF (fetal hemoglobin). These variants can be detected through specialized laboratory tests, such as hemoglobin electrophoresis or high-performance liquid chromatography (HPLC).
Blood protein electrophoresis (BPE) is a laboratory test that separates and measures the different proteins in the blood, such as albumin, alpha-1 globulins, alpha-2 globulins, beta globulins, and gamma globulins. This test is often used to help diagnose or monitor conditions related to abnormal protein levels, such as multiple myeloma, macroglobulinemia, and other plasma cell disorders.
In this test, a sample of the patient's blood is placed on a special gel and an electric current is applied. The proteins in the blood migrate through the gel based on their electrical charge and size, creating bands that can be visualized and measured. By comparing the band patterns to reference ranges, doctors can identify any abnormal protein levels or ratios, which may indicate underlying medical conditions.
It's important to note that while BPE is a useful diagnostic tool, it should be interpreted in conjunction with other clinical findings and laboratory tests for accurate diagnosis and management of the patient's condition.
Methemoglobin is a form of hemoglobin in which the iron within the heme group is in the ferric (Fe3+) state instead of the ferrous (Fe2+) state. This oxidation reduces its ability to bind and transport oxygen effectively, leading to methemoglobinemia when methemoglobin levels become too high. Methemoglobin has a limited capacity to release oxygen to tissues, which can result in hypoxia (reduced oxygen supply) and cyanosis (bluish discoloration of the skin and mucous membranes).
Methemoglobin is normally present in small amounts in the blood, but certain factors such as exposure to oxidizing agents, genetic predisposition, or certain medications can increase its levels. Elevated methemoglobin levels can be treated with methylene blue, which helps restore the iron within hemoglobin back to its ferrous state and improves oxygen transport capacity.
Methemoglobinemia is a medical condition characterized by an increased level of methemoglobin in the blood. Methemoglobin is a form of hemoglobin that cannot effectively transport oxygen throughout the body due to the iron atom within its structure being oxidized from the ferrous (Fe2+) state to the ferric (Fe3+) state.
Under normal circumstances, methemoglobin levels are kept below 1% of total hemoglobin. However, when these levels rise above 10%, it can lead to symptoms such as shortness of breath, headache, fatigue, and cyanosis (a bluish discoloration of the skin and mucous membranes). Severe methemoglobinemia, with levels exceeding 50%, can result in life-threatening complications, including seizures, coma, and even death.
Methemoglobinemia can be congenital or acquired. Congenital methemoglobinemia is caused by genetic defects affecting the enzymes responsible for reducing methemoglobin back to its functional form, hemoglobin. Acquired methemoglobinemia can result from exposure to certain medications, chemicals, or toxins that oxidize hemoglobin and increase methemoglobin levels. Treatment typically involves administering methylene blue, a reducing agent that helps convert methemoglobin back to functional hemoglobin. In severe cases or when methylene blue is contraindicated, alternative treatments such as exchange transfusions or hyperbaric oxygen therapy may be considered.
Erythrocyte count, also known as red blood cell (RBC) count, is a laboratory test that measures the number of red blood cells in a sample of blood. Red blood cells are important because they carry oxygen from the lungs to the rest of the body. A low erythrocyte count may indicate anemia, while a high count may be a sign of certain medical conditions such as polycythemia. The normal range for erythrocyte count varies depending on a person's age, sex, and other factors.
Erythrocyte deformability refers to the ability of red blood cells (erythrocytes) to change shape and bend without rupturing, which is crucial for their efficient movement through narrow blood vessels. This deformability is influenced by several factors including the cell membrane structure, hemoglobin concentration, and intracellular viscosity. A decrease in erythrocyte deformability can negatively impact blood flow and oxygen delivery to tissues, potentially contributing to various pathological conditions such as sickle cell disease, diabetes, and cardiovascular diseases.
Chromium isotopes are different forms of the chemical element Chromium (Cr), which have different numbers of neutrons in their atomic nuclei. This results in each isotope having a different atomic mass, although they all have the same number of protons (24) and therefore share the same chemical properties.
The most common and stable chromium isotopes are Chromium-52 (Cr-52), Chromium-53 (Cr-53), Chromium-54 (Cr-54), and Chromium-56 (Cr-56). The other less abundant isotopes of Chromium, such as Chromium-50 (Cr-50) and Chromium-51 (Cr-51), are radioactive and undergo decay to become stable isotopes.
Chromium is an essential trace element for human health, playing a role in the metabolism of carbohydrates, lipids, and proteins. It is also used in various industrial applications, such as in the production of stainless steel and other alloys.
I must clarify that "Iron Isotopes" is not a medical term, but rather a scientific concept from the field of physics and chemistry. However, I can certainly provide a general explanation of isotopes and then focus on iron isotopes specifically.
An isotope is a variant of a chemical element that has the same number of protons (and thus the same atomic number) but a different number of neutrons within its nucleus. This results in variations of the atomic mass of isotopes of the same element. Some isotopes are stable, while others are unstable and will decay over time into other elements or isotopes, a process called radioactive decay.
Iron (Fe) has four naturally occurring stable isotopes: Fe-54, Fe-56, Fe-57, and Fe-58. These iron isotopes have different numbers of neutrons in their nuclei, resulting in slightly different atomic masses. The most abundant iron isotope is Fe-56, which contains 26 protons and 30 neutrons in its nucleus.
In the context of human health, iron is an essential nutrient that plays a crucial role in various biological processes, such as oxygen transport and energy production. However, the concept of iron isotopes does not have a direct medical relevance, but it can be useful in scientific research related to fields like geochemistry, environmental science, or nuclear physics.
Erythrocytes, also known as red blood cells (RBCs), are the most common type of blood cell in circulating blood in mammals. They are responsible for transporting oxygen from the lungs to the body's tissues and carbon dioxide from the tissues to the lungs.
Erythrocytes are formed in the bone marrow and have a biconcave shape, which allows them to fold and bend easily as they pass through narrow blood vessels. They do not have a nucleus or mitochondria, which makes them more flexible but also limits their ability to reproduce or repair themselves.
In humans, erythrocytes are typically disc-shaped and measure about 7 micrometers in diameter. They contain the protein hemoglobin, which binds to oxygen and gives blood its red color. The lifespan of an erythrocyte is approximately 120 days, after which it is broken down in the liver and spleen.
Abnormalities in erythrocyte count or function can lead to various medical conditions, such as anemia, polycythemia, and sickle cell disease.
Sulfur isotopes are different forms of the chemical element sulfur, each with a distinct number of neutrons in their atomic nuclei. The most common sulfur isotopes are sulfur-32 (with 16 neutrons) and sulfur-34 (with 18 neutrons). These isotopes have similar chemical properties but different atomic masses, which can be used to trace the movement and cycling of sulfur through various environmental processes, such as volcanic emissions, bacterial metabolism, and fossil fuel combustion. The relative abundances of sulfur isotopes can also provide information about the origins and history of sulfur-containing minerals and compounds.
Heinz body - Wikipedia
Celestial bodies. Visual artist Irina Heinz
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Hemoglobin8
- Heinz bodies (also referred to as "Heinz-Ehrlich bodies") are inclusions within red blood cells composed of denatured hemoglobin. (wikipedia.org)
- The presence of Heinz bodies represents damage to hemoglobin and is classically observed in G6PD deficiency, a genetic disorder that causes hemolytic anemia. (wikipedia.org)
- Heinz bodies are formed by damage to the hemoglobin component molecules, usually through oxidative damage by administered drugs, or from an inherited mutation (i.e. change of an internal amino acid residue). (wikipedia.org)
- Oxidation of hemoglobin leads to methemoglobinemia and/or Heinz body formation. (ivis.org)
- They form Heinz bodies - clumps of hemoglobin that cannot transport oxygen as they should. (woodypet.com)
- ATSDR Case Studies: Nitrate/Nitrite Toxicity] In some cases, methemoglobin-forming compounds cause denaturation of hemoglobin (Heinz bodies) followed by hemolytic anemia. (haz-map.com)
- In rare instances, Heinz body anemia, methemoglobinemia, and hemoglobinuria may occur a few hours to 24 hours after exposure (ASPCA Animal Poison Control Center Antox: Unpublished data, 2011).5 In these cases, the thiols in the skunk spray cause oxidative damage to hemoglobin. (dvm360.com)
- Thiyl radicals and hydrogen peroxide are highly reactive and combine with hemoglobin sulfhydryl groups, resulting in Heinz bodies and subsequent hemolysis. (dvm360.com)
Hemolytic anemia2
- They are named after Robert Heinz (1865-1924), a German physician who in 1890 described these inclusions in connection with cases of hemolytic anemia. (wikipedia.org)
- The hemolytic anemia described in the article was caused by Heinz bodies, which is characteristic of poisoning by onions, although other chemicals are possible causes (copper, zinc, vitamin K) No one is claiming that low-dose garlic (or low-dose onions, for that matter) cause problems. (uvm.edu)
Hemolysis2
- Olson, p. 317] Subacute methemoglobinemia, oxidative hemolysis, and Heinz body anemia may develop in susceptible individuals exposed to chemicals that can induce methemoglobinemia. (haz-map.com)
- A further phenomenon of toxicity common to many hydrazine derivatives is hemolysis and the appearance of Heinz‑Ehrlich inclusion bodies in erythrocytes. (guidelinecentral.com)
Kraft Heinz13
- Kraft Heinz ( KHC ) Lunchables could be at sold at your child's school cafeteria this fall. (yahoo.com)
- It's the company's biggest 'away from home' innovation this year, a Kraft Heinz spokesperson told Yahoo Finance. (yahoo.com)
- Kraft Heinz did not reveal the terms of the deal to Yahoo Finance or potential costs for schools or students, but did say that they are working directly with school districts, which develop their own school cafeteria menus and will ultimately decide whether or not to offer the products. (yahoo.com)
- In 2022, Lunchables brought in $1.8 billion in sales and made up 8.6% of total Kraft Heinz sales. (yahoo.com)
- In order to meet the requirements of the NSLP , Kraft Heinz changed the original recipes to incorporate more protein and whole grains, reduced saturated fat and sodium, and increased serving size. (yahoo.com)
- A Kraft Heinz spokesperson said the revamped products are the 'latest example of the brand's commitment to the health and nutrition of consumers. (yahoo.com)
- schools'] labor needs and costs,' as seen on a sell sheet on the Kraft Heinz' food services website . (yahoo.com)
- Kraft Heinz director of corporate and government affairs Nigel Dickie insisted: "Heinz to Home is focused on frontline workers and has no impact at all on customers' deliveries. (thegrocer.co.uk)
- AP) - Kraft Heinz said Tuesday it's recalling more than 83,000 cases of individually-wrapped Kraft Singles American processed cheese slices because part of the wrapper could stick to the slice and become a choking hazard. (ktiv.com)
- Kraft Heinz said it initiated the voluntary recall after it received several consumer complaints. (ktiv.com)
- In six cases, people said the issue caused gagging or choking, but no injuries or serious health issues have been reported, Kraft Heinz said. (ktiv.com)
- Consumers who bought those products should not consume them and should return them to the store where they were purchased for an exchange or a refund, Kraft Heinz said. (ktiv.com)
- Consumers can also contact Kraft Heinz at 1-800-280-8252 to see if a product is part of the recall and to receive reimbursement. (ktiv.com)
Anemia3
- The denaturing process is irreversible and the continual elimination of damaged cells leads to Heinz body anemia. (wikipedia.org)
- According to the FDA "It was known for some time that propylene glycol caused Heinz Body formation in the red blood cells of cats (small clumps of proteins seen in the cells when viewed under the microscope), but it could not be shown to cause overt anemia or other clinical effects. (wikipedia.org)
- When used excessively or over an extended period, garlic may cause Heinz-body anemia, a potentially life-threatening blood disease. (mountaindogfood.com)
Hemoglobins1
- Heinz+Bodies at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Unstable Hemoglobins: The Role of Heme Loss in Heinz Body Formation" Jacon, Harry and Winterhalter, Kaspar, Proceedings of the National Academy of Sciences, Vol. 64, No3, pp. 697-701, March 1970 synd/658 at Who Named It? (wikipedia.org)
Dapsone1
- G6PD (glucose-6-phosphate dehydrogenase) deficiency exacerbated by administration of oxidant drugs (e.g., primaquine, dapsone, quinidine) can also result in Heinz bodies. (wikipedia.org)
RBCs1
- Transfusion of washed, leukocyte-poor red blood cells (RBCs) at approximately 8-15 mL RBCs per kilogram (kg) of body weight over 1-2 hours is recommended. (medscape.com)
Cells3
- G6PD deficient red cells in combination with high levels of oxidants causes a cross-linking of sulfhydryl groups on globin chains which causes a denaturing and formation of Heinz body precipitates. (wikipedia.org)
- The presence of Heinz bodies may also be a feature of hyposplenism or asplenia, when a damaged or absent spleen cannot remove these damaged cells from circulation. (wikipedia.org)
- The toxic compound in onions creates specific structural damage to the red blood cells called a Heinz bodies, which can be seen under a microscope. (petmd.com)
Inclusions1
- Heinz bodies appear as small round inclusions within the red cell body, though they are not visible when stained with Romanowsky dyes. (wikipedia.org)
Onions2
- Heinz bodies are associated with the consumption of paracetamol (acetaminophen), garlic, and onions by cats, dogs, and various primates. (wikipedia.org)
- Onion poisoning is consistently noted in pets who consume more than 0.5% of their body weight in onions. (petmd.com)
Dog's2
- And if Heinz bodies persist, remember to eliminate all food from the allium family which contains organosulfur compounds from your dog's diet. (woodypet.com)
- Not only do fats provide energy, but they also serve important roles in the normal development and function of your dog's body . (pawdiet.com)
Abnormalities1
- Hyperthyroidism has been associated with a variety of routine clinicopathological abnormalities such as mild to moderate erythrocytosis, macrocytosis, Heinz body anaemia and higher mean platelet size (8,23,26,27) . (vin.com)
Anthropometric2
- Composite body shape phenotypes of multiple anthropometric traits and risk of cancer development (INCa-ShapeCancer). (who.int)
- Comfortable fitting exoskeleton suits that are adaptable to a variety of body shapes require multivariate or 3-dimensional anthropometric data in the design process [9,10]. (cdc.gov)
Inhalation1
- CFC-12 was tested by inhalation on Sprague-Dawley rats and Swiss Mice using whole body exposure. (europa.eu)
Fluids5
- Heinz Feldmann] Well, Ebola is contagious but it is not transmitted through the air and by aerosols, at least that there's no good evidence, and it's transmitted largely through direct contact with body fluids from an infected individual. (cdc.gov)
- So once a case comes into a hospital setting and gets treated under low hygiene standards in resource-poor areas, then human-to-human transmission through direct contact with body fluids is the main way of transmission. (cdc.gov)
- To provide guidance for implementing such practices, this article reviews how HIV is transmitted, including the presence of HIV in various body fluids and the risk of transmission after various exposures, and provides specific guidelines for preventing the transmission of HIV in settings where children are cared for. (cdc.gov)
- The serious nature of HIV infection, the presence of HIV in a variety of body fluids and the close contact that children often enjoy with their playmates and caretakers have combined to generate considerable concern about HIV transmission in homes, schools, day-care centers and playgrounds. (cdc.gov)
- Presence of HIV in body fluids. (cdc.gov)
Garlic2
- So if a dog has too much garlic for too long, just removing the garlic for a while will allow the body to heal completely. (verm-x.com)
- It has also been found that garlic contains a compound that inhibits various forms of cancerous growths in the body, by strengthening the actions of the liver. (mountaindogfood.com)
Blood1
- Carrots also contain vitamin C, a nutrient that helps produce collagen in bones, muscle, cartilage and blood vessels so that iron can be absorbed by the body. (howstuffworks.com)
Composition2
- the effect of breastfeeding over the body mass components still demands analyses aiming to further investigate the body composition evolution in the after-breastfeeding childhood. (bvsalud.org)
- analyze the influence of breastfeeding (BF) over the body composition of children under 3 years old. (bvsalud.org)
Weight2
- Children exposed to the same levels of aniline vapor as adults may receive larger dose because they have greater lung surface area:body weight ratios and increased minute volumes:weight ratios. (cdc.gov)
- Children are more vulnerable to toxicants absorbed through the skin because of their relatively larger surface area:body weight ratio. (cdc.gov)
Immune1
- A substance added to killed vaccines to stimulate a better immune response by the body. (mysanantoniovet.com)
Time5
- After both Heinz and Margot were "called up" to work in a Nazi Labor camp, they went into hiding at roughly the same time. (nctcsf.org)
- Heinz Geiringer left over twenty paintings and a book of poetry which show us both his hope for the future and the terror of the time. (nctcsf.org)
- A trained musician, Heinz turned to painting and poetry to utilize his time. (nctcsf.org)
- The venture seems a nice initiative from the Heinz marketing team and comes at the right time for the brand to be making noise about supporting the nation," said Bestway Wholesale MD Dawood Pervez. (thegrocer.co.uk)
- Our purpose is to help feed the nation at this time of need and we are working day and night to replenish retailers and wholesalers with our most popular Heinz varieties, and provide stock for care packages to be distributed to the elderly and vulnerable, as well as deliver on our charitable commitments. (thegrocer.co.uk)
Cases2
- The 'bodies' are named after Robert Heinz (1865-1924), a German doctor who, in 1890, described them in connection with human cases of destructive anaemia. (verm-x.com)
- So if you look at the overall cases, this is really the vast majority of cases just by human-to-human contact and human-to-human body fluid contact. (cdc.gov)
Mechanical1
- Occupational exoskeletons are "wearable devices that augment, enable, assist, and/or enhance physical activity through mechanical interaction with the body. (cdc.gov)
Year1
- A year ago, Heinz Field was the scene of a performance the Pittsburgh Steelers won't soon forget. (patriots.com)
Products2
- Discover a new generation of leather jacket, unique and unmistakable, the products of Heinz Bauer Manufakt are masterpieces of craftsmanship. (mersmann.com)
- Heinz has confirmed over the coming days and weeks further products will be added, including Tomato Ketchup. (thegrocer.co.uk)
Result1
- As a result of his extraordinary body of work, Nachtwey has just received a Heinz Award in the Arts and Humanities. (leoweekly.com)
Size2
- Not only is there is no consensus on the upper limit of normal size, but splenic size varies with age, geographic origin, and body size. (medscape.com)
- 2014) factors, adipokines, and body size in epidemiological studies, in collaboration and to identify novel dietary biomarkers young Mexican women have been inves- with NEP. (who.int)
Effects2
- Thus, the breastfeeding effect over the body mass components still requires additional analysis, especially to identify the breastfeeding effects over children body fat. (bvsalud.org)
- Occupational exoskeleton technologies are rapidly developing and so is the body of evidence regarding their potential effects on workers in diverse applications [8]. (cdc.gov)
AGEs1
- It is imperative to assess the critical dimensions and configurations of exoskeletons to make them applicable to and effective for use in a wide range of tasks and to ensure fit, comfort, and usability for a broad set of users of different sizes and body types, genders, and ages [8]. (cdc.gov)
Arts1
- Heinz loved the arts. (nctcsf.org)
Work1
- From the tender age of fifteen to seventeen, Heinz created a body of work that exists to this day. (nctcsf.org)
Found1
- Heinz bodies can also be found in chronic liver disease. (wikipedia.org)
Impact1
- Heinz has insisted its newly launched direct-to-consumer venture will not impact its ability to supply its wholesale and convenience customers. (thegrocer.co.uk)
Whole body1
- But usually in a lethal or in a very severe and lethal case, around day 7-10 people start develop more systemic, whole-body symptoms. (cdc.gov)
Multiple1
- As the largest organ of the body, the skin performs multiple critical functions, such as serving as the primary barrier to the external environment. (cdc.gov)
Days1
- Heinz Feldmann] Well, Ebola is on everybody's mind these days and that's largely due to that big outbreak in West Africa from 2013-2016. (cdc.gov)
Book1
- The Rigid Body Kinematics book by Batlle and Barjau presents the concepts of kinematics for points, rigid bodies and multibody systems with a depth and thoroughness which is not common in textbooks nowadays. (books-express.ro)
Effect1
- The effect of predominant breastfeeding over the mass gain and body fat gain evolution in children up to three years old will be evaluated in this study. (bvsalud.org)
Account1
- Rigid Body Kinematics provides a clear and comprehensive account of the kinematics of rigid bodies in three-dimensional space, built from the ground up. (books-express.ro)