A cellular subtype of malignant melanoma. It is a pigmented lesion composed of melanocytes occurring on sun-exposed skin, usually the face and neck. The melanocytes are commonly multinucleated with a "starburst" appearance. It is considered by many to be the in situ phase of lentigo maligna melanoma.
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.
Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.
A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.
Color of hair or fur.
Coloration of the skin.
Irradiation directly from the sun.
Tumors or cancer of the SKIN.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Hutchinson's melanotic freckle, also known as Hutchinson's melanotic macule or naevus, is a type of pigmented lesion that can be a precursor to malignant melanoma, a serious form of skin cancer. It is typically characterized by the presence of darkly pigmented, irregularly shaped patches on the skin, often found on the face or neck.

The lesions are usually brown or black in color and may have an uneven border or surface. They can vary in size from a few millimeters to several centimeters in diameter. Hutchinson's melanotic freckles are typically larger, darker, and more irregularly shaped than common freckles.

These lesions are named after Sir Jonathan Hutchinson, an English surgeon and pathologist who first described them in the late 19th century. It is important to note that while Hutchinson's melanotic freckles can be a sign of increased risk for developing melanoma, not all such lesions will become cancerous. However, any changes in size, shape, or color of these lesions should be evaluated by a healthcare professional as soon as possible.

Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare and fatal genetic condition characterized by the rapid aging of children. The term "progeria" comes from the Greek words "pro," meaning prematurely, and "gereas," meaning old age.

Individuals with progeria typically appear normal at birth but begin to display signs of accelerated aging within the first two years of life. These symptoms can include growth failure, loss of body fat and hair, aged-looking skin, joint stiffness, hip dislocation, and cardiovascular disease. The most common cause of death in progeria patients is heart attack or stroke due to widespread atherosclerosis (the hardening and narrowing of the arteries).

Progeria is caused by a mutation in the LMNA gene, which provides instructions for making a protein called lamin A. This protein is essential for the structure and function of the nuclear envelope, the membrane that surrounds the cell's nucleus. The mutation leads to the production of an abnormal form of lamin A called progerin, which accumulates in cells throughout the body, causing premature aging.

There is currently no cure for progeria, and treatment is focused on managing symptoms and complications. Researchers are actively studying potential treatments that could slow or reverse the effects of the disease.

Melanosis is a general term that refers to an increased deposit of melanin, the pigment responsible for coloring our skin, in the skin or other organs. It can occur in response to various factors such as sun exposure, aging, or certain medical conditions. There are several types of melanosis, including:

1. Epidermal melanosis: This type of melanosis is characterized by an increase in melanin within the epidermis, the outermost layer of the skin. It can result from sun exposure, hormonal changes, or inflammation.
2. Dermal melanosis: In this type of melanosis, there is an accumulation of melanin within the dermis, the middle layer of the skin. It can be caused by various conditions such as nevus of Ota, nevus of Ito, or melanoma metastasis.
3. Mucosal melanosis: This type of melanosis involves an increase in melanin within the mucous membranes, such as those lining the mouth, nose, and genitals. It can be a sign of systemic disorders like Addison's disease or Peutz-Jeghers syndrome.
4. Lentigo simplex: Also known as simple lentigines, these are small, benign spots that appear on sun-exposed skin. They result from an increase in melanocytes, the cells responsible for producing melanin.
5. Labial melanotic macule: This is a pigmented lesion found on the lips, typically the lower lip. It is more common in darker-skinned individuals and is usually benign but should be monitored for changes that may indicate malignancy.
6. Ocular melanosis: An increase in melanin within the eye can lead to various conditions such as ocular melanocytosis, oculodermal melanocytosis, or choroidal melanoma.

It is important to note that while some forms of melanosis are benign and harmless, others may indicate an underlying medical condition or even malignancy. Therefore, any new or changing pigmented lesions should be evaluated by a healthcare professional.

Iris neoplasms refer to abnormal growths or tumors that develop in the iris, which is the colored part of the eye. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Benign iris neoplasms are typically slow-growing and do not spread to other parts of the body. Malignant iris neoplasms, on the other hand, can grow quickly and may spread to other parts of the eye or nearby structures, such as the ciliary body or choroid.

Iris neoplasms can cause various symptoms, including changes in the appearance of the eye, such as a visible mass or discoloration, pain, redness, light sensitivity, blurred vision, or changes in the size or shape of the pupil. The diagnosis of iris neoplasms typically involves a comprehensive eye examination, including a visual acuity test, refraction, slit-lamp examination, and sometimes imaging tests such as ultrasound or optical coherence tomography (OCT).

Treatment options for iris neoplasms depend on the type, size, location, and severity of the tumor. Small, benign iris neoplasms may not require treatment and can be monitored over time. Larger or malignant iris neoplasms may require surgical removal, radiation therapy, or other treatments to prevent complications or spread to other parts of the eye or body. It is essential to seek medical attention promptly if you experience any symptoms of iris neoplasms or notice any changes in your vision or the appearance of your eyes.

A nevus, also known as a mole, is a benign growth or mark on the skin that is usually brown or black. It can be raised or flat and can appear anywhere on the body. Nevi are made up of cells called melanocytes, which produce the pigment melanin. Most nevi develop in childhood or adolescence, but they can also appear later in life. Some people have many nevi, while others have few or none.

There are several types of nevi, including:

* Common nevi: These are the most common type of mole and are usually small, round, and brown or black. They can be flat or raised and can appear anywhere on the body.
* Atypical nevi: These moles are larger than common nevi and have irregular borders and color. They may be flat or raised and can appear anywhere on the body, but are most commonly found on the trunk and extremities. Atypical nevi are more likely to develop into melanoma, a type of skin cancer, than common nevi.
* Congenital nevi: These moles are present at birth and can vary in size from small to large. They are more likely to develop into melanoma than moles that develop later in life.
* Spitz nevi: These are rare, benign growths that typically appear in children and adolescents. They are usually pink or red and dome-shaped.

It is important to monitor nevi for changes in size, shape, color, and texture, as these can be signs of melanoma. If you notice any changes in a mole, or if you have a new mole that is unusual or bleeding, it is important to see a healthcare provider for further evaluation.

Homologous transplantation is a type of transplant surgery where organs or tissues are transferred between two genetically non-identical individuals of the same species. The term "homologous" refers to the similarity in structure and function of the donated organ or tissue to the recipient's own organ or tissue.

For example, a heart transplant from one human to another is an example of homologous transplantation because both organs are hearts and perform the same function. Similarly, a liver transplant, kidney transplant, lung transplant, and other types of organ transplants between individuals of the same species are also considered homologous transplantations.

Homologous transplantation is in contrast to heterologous or xenogeneic transplantation, where organs or tissues are transferred from one species to another, such as a pig heart transplanted into a human. Homologous transplantation is more commonly performed than heterologous transplantation due to the increased risk of rejection and other complications associated with xenogeneic transplants.

Hematopoietic Stem Cell Transplantation (HSCT) is a medical procedure where hematopoietic stem cells (immature cells that give rise to all blood cell types) are transplanted into a patient. This procedure is often used to treat various malignant and non-malignant disorders affecting the hematopoietic system, such as leukemias, lymphomas, multiple myeloma, aplastic anemia, inherited immune deficiency diseases, and certain genetic metabolic disorders.

The transplantation can be autologous (using the patient's own stem cells), allogeneic (using stem cells from a genetically matched donor, usually a sibling or unrelated volunteer), or syngeneic (using stem cells from an identical twin).

The process involves collecting hematopoietic stem cells, most commonly from the peripheral blood or bone marrow. The collected cells are then infused into the patient after the recipient's own hematopoietic system has been ablated (or destroyed) using high-dose chemotherapy and/or radiation therapy. This allows the donor's stem cells to engraft, reconstitute, and restore the patient's hematopoietic system.

HSCT is a complex and potentially risky procedure with various complications, including graft-versus-host disease, infections, and organ damage. However, it offers the potential for cure or long-term remission in many patients with otherwise fatal diseases.

A nevus pigmentosus, also known as a pigmented mole or melanocytic nevus, is a benign proliferation of melanocytes, the pigment-producing cells in the skin. These lesions typically appear as well-circumscribed, brown to black macules or papules. They can vary in size and shape and may be flat or raised. Most nevi are harmless and do not require treatment; however, some may undergo malignant transformation into melanoma, a potentially life-threatening skin cancer. Regular self-skin examinations and professional skin checks are recommended to monitor for changes in nevi that may indicate malignancy.

I'm sorry for any confusion, but "hair color" is not a term that has a medical definition in the same way that a term like "myocardial infarction" (heart attack) does. Hair color can be described in various ways, such as being a natural hair color (like blonde, brunette, red, or black) or describing a change in hair color due to factors like aging (gray or white hairs) or hair dye usage.

However, it's worth noting that changes in hair color can sometimes be associated with certain medical conditions. For example, premature graying of the hair before the age of 30 can be a feature of certain genetic disorders or vitamin B12 deficiency. Similarly, some skin conditions like alopecia areata or vitiligo can cause patchy changes in hair color. But these associations don't provide a medical definition for 'hair color'.

Skin pigmentation is the coloration of the skin that is primarily determined by two types of melanin pigments, eumelanin and pheomelanin. These pigments are produced by melanocytes, which are specialized cells located in the epidermis. Eumelanin is responsible for brown or black coloration, while pheomelanin produces a red or yellow hue.

The amount and distribution of melanin in the skin can vary depending on genetic factors, age, sun exposure, and various other influences. Increased production of melanin in response to UV radiation from the sun helps protect the skin from damage, leading to darkening or tanning of the skin. However, excessive sun exposure can also cause irregular pigmentation, such as sunspots or freckles.

Abnormalities in skin pigmentation can result from various medical conditions, including albinism (lack of melanin production), vitiligo (loss of melanocytes leading to white patches), and melasma (excessive pigmentation often caused by hormonal changes). These conditions may require medical treatment to manage or improve the pigmentation issues.

I'm sorry for any confusion, but "sunlight" is not a term with a specific medical definition. However, sunlight does have various implications in the field of medicine. It is the light that comes from the sun, which is a star at the center of our solar system. Sunlight is essential for the production of vitamin D in humans, and it can also have effects on mood and sleep patterns due to its influence on circadian rhythms.

In a medical context, sunlight is often discussed in relation to its potential health benefits and risks. For instance, moderate sun exposure can help increase vitamin D levels, which are important for bone health, immune function, and other bodily processes. However, excessive sun exposure can lead to harmful effects, such as sunburn, premature skin aging, and an increased risk of skin cancer.

It's essential to balance the benefits and risks of sunlight exposure by practicing safe sun habits, such as wearing protective clothing, using a broad-spectrum sunscreen with an SPF of at least 30, seeking shade during peak sunlight hours, and avoiding intentional tanning.

Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.

Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.

It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.

Melanoma is defined as a type of cancer that develops from the pigment-containing cells known as melanocytes. It typically occurs in the skin but can rarely occur in other parts of the body, including the eyes and internal organs. Melanoma is characterized by the uncontrolled growth and multiplication of melanocytes, which can form malignant tumors that invade and destroy surrounding tissue.

Melanoma is often caused by exposure to ultraviolet (UV) radiation from the sun or tanning beds, but it can also occur in areas of the body not exposed to the sun. It is more likely to develop in people with fair skin, light hair, and blue or green eyes, but it can affect anyone, regardless of their skin type.

Melanoma can be treated effectively if detected early, but if left untreated, it can spread to other parts of the body and become life-threatening. Treatment options for melanoma include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, depending on the stage and location of the cancer. Regular skin examinations and self-checks are recommended to detect any changes or abnormalities in moles or other pigmented lesions that may indicate melanoma.

"Hutchinson's melanotic freckle". This is named for Jonathan Hutchinson. The word lentiginous comes from the latin for freckle. ... Green A, Little JH, Weedon D (January 1983). "The diagnosis of Hutchinson's melanotic freckle (lentigo maligna) in Queensland ... synd/1439 at Who Named It? J. Hutchinson. Senile freckle with deep staining - a superficial epithelioma of the cheek. Archives ...
... hutchinson's melanotic freckle MeSH C04.557.465.625.650.510.515 - melanoma, amelanotic MeSH C04.557.465.625.650.510.525 - ... hutchinson's melanotic freckle MeSH C04.557.580.625.650.510.515 - melanoma, amelanotic MeSH C04.557.580.625.650.510.525 - ... hutchinson's melanotic freckle MeSH C04.557.665.510.515 - melanoma, amelanotic MeSH C04.557.665.510.525 - melanoma, ... melanotic MeSH C04.557.465.625.650 - neuroendocrine tumors MeSH C04.557.465.625.650.025 - adenoma, acidophil MeSH C04.557. ...
... dehidrosis Hutchinson's disease or senile degeneration of the choroid Hutchinson's facies Hutchinson's melanotic freckle (was ... Hutchinson's prurigo Hutchinson's pupil Hutchinson's teeth (seen in congenital syphilis) Hutchinson's triad Hutchinson-Gilford ... Hutchinson has his name attached to these entities in medicine: Hutchinson's angina Hutchinson's sign Hutchinson's ... Hutchinson's mask Hutchinson's melanotic disease Hutchinson's patch (a corneal sign attached to syphilitic keratitis) ...
NOS M8741/3 Malignant melanoma in precancerous melanosis M8742/3 Lentigo maligna melanoma Hutchinson melanotic freckle M8743/3 ... with glandular differentiation Epithelioid with mesenchymal differentiation Melanotic Melanotic psammomatous M9541/0 Melanotic ... Transitional pineal tumor M9363/0 Melanotic neuroectodermal tumor Retinal anlage tumor Melanoameloblastoma Melanotic progonoma ... NOS Melanotic medulloblastoma M9471/3 Desmoplastic nodular medulloblastoma Desmoplastic medulloblastoma Circumscribed ...
Hutchinson-Gilford progeria syndrome, Hutchinson-Gilford syndrome, progeria syndrome) Progressive osseous heteroplasia ... senile freckle) Melanoma is a malignant proliferation of melanocytes and the most aggressive type of skin cancer. Acral ... melanotic macules) Nevus of Ito (nevus fuscoceruleus acromiodeltoideus) Nevus of Ota (congenital melanosis bulbi, melanosis ... Hutchinson's summer prurigo, hydroa aestivale) Aerosol burn Benign summer light eruption Beryllium granuloma Black heel and ...
"Hutchinsons melanotic freckle". This is named for Jonathan Hutchinson. The word lentiginous comes from the latin for freckle. ... Green A, Little JH, Weedon D (January 1983). "The diagnosis of Hutchinsons melanotic freckle (lentigo maligna) in Queensland ... synd/1439 at Who Named It? J. Hutchinson. Senile freckle with deep staining - a superficial epithelioma of the cheek. Archives ...
... the disease continues to be called Hutchinson melanotic freckle on occasion. The Hutchinson melanotic freckle was originally ... Sir John Hutchinson first described lentigo maligna in 1890; ...
iris freckles small, pigmented clusters of uveal melanocytes on the surface of the iris. melanotic f. SYN: lentigo maligna. ... O. E. freken] Hutchinson f. SYN: lentigo maligna. ... freckle (frek′l). Yellowish or brownish macules developing on ...
M]Hutchinsons melanotic freckle Active Synonym false false 2842275010 Hutchinson melanotic freckle Active Synonym false false ... Hutchinsons melanotic freckle Active Synonym false false 101726010 Lentigo maligna Active Synonym false false ...
Hutchinson melanotic freckle; lentigo maligna melanoma in situ.. Epidemiology. 10-15% of all melanoma. Slight female ...
Hutchinson's Melanotic Freckle, Nevus, Spindle Cell, Epithelioid Cells, Nevus, Epithelioid and Spindle Cell, Nevus, ...
They develop from very slow growing pigmented areas of skin called lentigo maligna or Hutchinsons melanotic freckle. This type ...
Lentigo maligna (melanotic freckle of Hutchinson), most common on the face and after the age of 50, first appears as a flat ... They generally appear by the time a person is 20 and resemble freckles at first. A moles color and shape dont usually change ...
Hutchinsons Melanotic Freckle. *Mohs Surgery. *Skin Neoplasms. _. Top Journals Top journals in which articles about this ...
Hutchinsons melanotic freckle. *Hyperhidrosis. I *Ichthyosis. *Icterus gravidarum. *Idiopathic jaundice of pregnancy ...
Hutchinsons melanotic freckle. *Hyperhidrosis. I *Ichthyosis. *Icterus gravidarum. *Idiopathic jaundice of pregnancy ...
Malignant Lentigo use Hutchinsons Melanotic Freckle Malignant Lentigos use Hutchinsons Melanotic Freckle ...
Malignant Lentigo use Hutchinsons Melanotic Freckle Malignant Lentigos use Hutchinsons Melanotic Freckle ...
Malignant Lentigo use Hutchinsons Melanotic Freckle Malignant Lentigos use Hutchinsons Melanotic Freckle ...
Malignant Lentigo use Hutchinsons Melanotic Freckle Malignant Lentigos use Hutchinsons Melanotic Freckle ...
Malignant Lentigo use Hutchinsons Melanotic Freckle Malignant Lentigos use Hutchinsons Melanotic Freckle ...
Hutchinsons Melanotic Freckle/diagnosis/*pathology, Immunohistochemistry, Jorizzo Joseph L, Journal of the American Academy of ...
Hutchinsons Melanotic Freckle/diagnosis/*pathology, Immunohistochemistry, Jorizzo Joseph L, Journal of the American Academy of ...
... fre frea freak freakbrothers freakish freakishly freakishness freaks frealaf freawine freckle freckled freckles freckling ... husks husky husnaes hussar hussy hustat hustings hustle hustled hustler hustles hustling huston hut hutch hutchins hutchinson ... melanistic melanite melanitic melanize melanochroi melanochroic melanoid melanoma melanomas melanomata melanosis melanotic ... Francis7 Francis8 Francis9 Francisco Franco Frank Frank1 Frankenthal Franklin Frantz Franz Franz1 Fraser Fraternity Freckle ...
... freakish freakishly freakishness freakout freakouts freaks freaky freckle freckled freckles frecklier freckliest freckling ... hussy hustings hustle hustled hustler hustlers hustles hustling Huston hut hutch hutched hutches hutching Hutchins Hutchinson ... melanocyte melanogen melanogenesis melanoid melanoids melanoma melanomas melanomata melanophore melanosis melanotic melatonin ...
... frazzling freak freakier freakish freakishly freakishness freaks freaks freaky Freccia freckle freckled freckles freckling ... Hussite hussy hustings hustle hustled hustler hustlers hustles hustling Huston Hustons hut hutch hutchie Hutchins Hutchinson ... melanoblastoma Melanochroi melanochroic melanocyte melanogenesis melanoid melanoma melanophore melanosis melanotic melanous ...
... frazzling freak freakier freakish freakishly freakishness freaks freaks freaky Freccia freckle freckled freckles freckling ... Hussite hussy hustings hustle hustled hustler hustlers hustles hustling Huston Hustons hut hutch hutchie Hutchins Hutchinson ... melanoblastoma Melanochroi melanochroic melanocyte melanogenesis melanoid melanoma melanophore melanosis melanotic melanous ...
ARIOSO CONCURRENT LARYNGOSTENOSIS BOBBLE UNMASKED GEMMING OVERSIGHT COSTLIER DITCHED SKEEING SHMALTZ DEBASE DEBARK FRECKLES ... GRAVITONS BEDNIGHTS MIMICRY MILKSOP RECOUNTING SECULARS SMELTERIES AWARDEES PRESCRIBING WHOREDOMS UNIMPASSIONED MELANOTIC ... BAYONETTING CESSPIT WOOLLIER OVERSTRIKES UNCLAMPS INTERCESSORS COLLOIDS GALLING MILANESE AGGREGATING WEIGHTLESSLY HUTCHINSON ... SELECTOR COLOURER REDISCOUNT INFLATIONISM SWASTIKA INCREMENTS INTERMEDIARIES NODULOSE UNIONIZERS INELIGIBLE RUCHING FRECKLING ...
  • They develop from very slow growing pigmented areas of skin called lentigo maligna or Hutchinson's melanotic freckle. (survivornet.ca)
  • 16. Acral lentiginous melanoma or Hutchinson's melanotic freckle of the extremities. (nih.gov)
  • Evidence is presented suggesting that superficial spreading melanoma and lentigo maligna melanoma (Hutchinson's melanotic freckle), though evolving at different rates, show a long period of superficial growth, followed by the relatively rapid appearance of nodules or deeper invasion within the primary lesion. (aacrjournals.org)
  • Lentigo maligna (LM), historically known as Hutchinson's melanotic freckle, is a subtype of melanoma in situ characterised by atypical intraepidermal melanocytes that usually occurs in sun damaged skin. (cancer.org.au)
  • Lentigo maligna (Hutchinson's melanotic freckle) is considered the premalignant lesion of lentigo maligna melanoma. (idahoeyelidandface.com)
  • Initial lesions, such as dryness of the skin and freckles on the face, were noticed in all patients. (nih.gov)
  • It grows very slowly from pigmented areas of skin referred to as lentigo maligna or Hutchinson's melanotic freckles. (healthandconditions.com)