Hyperandrogenism
Polycystic Ovary Syndrome
Hirsutism
Acne Vulgaris
Virilism
Nafarelin
Androgens
Testosterone
Acanthosis Nigricans
17-alpha-Hydroxyprogesterone
Androstenedione
Acneiform Eruptions
Dehydroepiandrosterone Sulfate
Puberty, Precocious
Adrenal Hyperplasia, Congenital
Luteoma
Sex Hormone-Binding Globulin
Anti-Mullerian Hormone
Neoplasms, Gonadal Tissue
Ovary
Dehydroepiandrosterone
Anovulation
Metformin
Insulin Resistance
Hyperinsulinism
Luteinizing Hormone
Steroid 17-alpha-Hydroxylase
Hormones
Menstrual Cycle
Theca Cells
Insulin
Follicle Stimulating Hormone
Obesity
Glucose Tolerance Test
Adrenal Glands
Body Mass Index
Steroids
Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism. (1/197)
Gonadal steroids are believed to influence glucose metabolism, oestrogens inducing an improvement and androgens or progestins a deterioration. At baseline and after 3 months of ovarian suppression with a gonadotrophin-releasing hormone analogue (GnRHa: goserelin depot 3.75 mg/28 days), glucose metabolism was evaluated in eight lean women affected by ovarian hyperandrogenism (PCOS) and six age-weight-matched non-hyperandrogenic women (controls) by using both an oral glucose tolerance test (75 g; OGTT) and the minimal model method. The latter method allows calculation of peripheral insulin sensitivity (Si) and glucose dependent glucose utilization (Sg). In PCOS, higher fasting concentrations (P < 0.05) of insulin and C-peptide, and lower Sg (P < 0.05) and Si (P < 0.01) were found. GnRHa did not significantly modify glucose metabolism of controls, while in women with PCOS it decreased fasting glucose (P < 0.05) and significantly increased Si (P < 0.03) up to control values. The present data indicate that strong suppression of ovarian activity improves Si in lean women with PCOS, while it is without relevant effects on glucose metabolism of non-hyperandrogenic women. (+info)Dexamethasone supplementation to gonadotropin stimulation for in vitro fertilization in polycystic ovarian disease. (2/197)
PURPOSE: This study was conducted to determine whether glucocorticoid supplementation for patients with polycystic ovarian disease during ovulation induction with gonadotropins for in vitro fertilization (IVF) therapy is beneficial. METHODS: Seventy-one cycles of patients undergoing first attempts at IVF, with classical polycystic ovarian disease and hyperandrogenemia, who enrolled in the IVF-embryo transfer program, were evaluated retrospectively. In 20 cycles (20 patients) glucocorticoid supplementation was noted and compared to 51 cycles (51 patients) without glucocorticoid as adrenal androgen suppression. Ovaries were stimulated by gonadotropin releasing hormone agonist, human menopausal gonadotropin, and dexamethasone. Ovarian responsiveness and IVF-embryo transfer outcome were analyzed and included the number of follicles > 17 mm in diameter, serum estradiol concentration on the day of human chorionic gonadotropin administration, number of human chorionic gonadotropin ampoules administered, number of oocytes retrieved, percentage of oocytes fertilized, number of embryos transferred, implantation rate, and number of clinical pregnancies and their outcome. RESULTS: The results showed that the pregnancy rate in patients who received glucocorticoid was 22.1%, compared to 26% in the controls (statistically insignificant). The IVF cycle variables studied revealed no statistically significant differences. CONCLUSIONS: Our observations did not support the notion that adrenal androgen suppression by glucocorticoid, or as an adjuvant therapy, is beneficial to patients with polycystic ovarian disease who enrolled in an IVF-embryo transfer program. (+info)Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. (3/197)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of women, characterized by hyperandrogenism and chronic anovulation. It is a leading cause of female infertility and is associated with polycystic ovaries, hirsutism, obesity, and insulin resistance. We tested a carefully chosen collection of 37 candidate genes for linkage and association with PCOS or hyperandrogenemia in data from 150 families. The strongest evidence for linkage was with the follistatin gene, for which affected sisters showed increased identity by descent (72%; chi(2) = 12.97; nominal P = 3.2 x 10(-4)). After correction for multiple testing (33 tests), the follistatin findings were still highly significant (P(c) = 0.01). Although the linkage results for CYP11A were also nominally significant (P = 0.02), they were no longer significant after correction. In 11 candidate gene regions, at least one allele showed nominally significant evidence for population association with PCOS in the transmission/disequilibrium test (chi(2) >/= 3.84; nominal P < 0.05). The strongest effect in the transmission/disequilibrium test was observed in the INSR region (D19S884; allele 5; chi(2) = 8.53) but was not significant after correction. Our study shows how a systematic screen of candidate genes can provide strong evidence for genetic linkage in complex diseases and can identify those genes that should have high (or low) priority for further study. (+info)Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status. (4/197)
OBJECTIVE: To study the incidence of 21-hydroxylase deficiency in Slovenian hyperandrogenic women, at the gene level. Previous endocrine studies indicated large differences in the incidence of 21-hydroxylase deficiency in hyperandrogenic women. The predictive values of the 17-hydroxyprogesterone (17-OHP) response to ACTH stimulation and of HLA typing in screening for carrier status were re-evaluated. DESIGN: Molecular analysis of CYP21 gene, ACTH stimulation and human leucocyte antigen (HLA) typing were performed in 83 consecutive Slovenian hyperandrogenic women. MEASUREMENTS: Cortisol and 17-OHP concentrations were measured at baseline and 60 min after ACTH stimulation. Basal adrenal androgen concentrations were also measured. RESULTS: None of 83 hyperandrogenic patients was affected with non-classical 21-hydroxylase deficiency, but 12 of 81 patients (14.8%) had high concentrations of 17-OHP after stimulation, indicative of carrier status. The increase in 17-OHP concentrations could be explained by a carrier status for CYP21 gene mutations in only three of 12 patients (25%), whereas seven of 69 patients (10. 1%) with normal concentrations of 17-OHP after stimulation were found to be carriers of CYP21 gene mutations, indicating low positive predictive values of ACTH stimulation as a screening test for carriers of 21-hydroxylase deficiency. In total, 11 carriers were identified among 83 patients: seven CYP21 gene deletions/conversions, two Gln(318)Stop and one Val(281)Leu mutation and one gene conversion extending from exon 4 to exon 7 were found. The association between Val(281)Leu mutation and HLA-B14 antigen was confirmed in this Slovenian population. CONCLUSIONS: Basal or ACTH-stimulated 17-OHP concentrations are not a good indicator of the carrier status for 21-hydroxylase deficiency among Slovenian hyperandrogenic patients. Reliable screening for carriers of 21-hydroxylase deficiency is possible only by molecular analysis of the CYP21 gene. (+info)Clearance of acanthosis nigricans associated with the HAIR-AN syndrome after partial pancreatectomy: an 11-year follow-up. (5/197)
We describe a woman with the syndrome characterised by hyperandrogenism, insulin resistance and acanthosis nigricans (the HAIR-AN syndrome), and an associated insulinoma (islet B-cell tumour), whose signs and symptoms cleared after partial pancreatectomy. (+info)Clinical presentation of PCOS following development of an insulinoma: case report. (6/197)
A 24 year old woman presented with a prolonged clinical history of fasting and exertional hypoglycaemia, and was subsequently diagnosed with an insulinoma. Concurrent symptoms of oligomenorrhoea and hyperandrogenism of similar duration were noted. Biochemically, hyperinsulinaemia was observed in association with a raised serum luteinizing hormone (LH), raised testosterone and androstendione concentrations. Surgical removal of the insulinoma resulted in resolution of the clinical and biochemical features of the polycystic ovarian syndrome (PCOS) but minimal change was observed in the ovarian ultrasound appearances. This case demonstrates the role of insulin in mediating the hypersecretion of both LH and androgens in women with polycystic ovaries. We suggest that hyperinsulinaemia converted occult 'polycystic ovaries' to become clinically manifest as 'polycystic ovary syndrome'. This paradigm has clear implications for women with insulin dependent diabetes mellitus who presumably have systemic hyperinsulinaemia. (+info)Use of a long-acting gonadotrophin-releasing hormone analogue in a postmenopausal woman with hyperandrogenism due to a hilus cell tumour. (7/197)
OBJECTIVE: The aim of this study was to prove the utility of GnRH analogues for the suppression of androgen secretion in a postmenopausal woman with a suspected virilizing ovarian tumour. DESIGN AND METHODS: We present a case of a 72-year-old woman with virilization of recent onset. Hormonal studies revealed a fourfold increase in serum testosterone levels, normal dehydroepiandrosterone sulphate concentrations and high levels of serum 17-hydroxyprogesterone levels. Computed axial tomography scan of the ovaries was normal and the adrenal glands showed a discrete enlargement. The long-acting GnRH analogue, triptorelin, was injected initially (3.75mg i.m.) and serum hormone levels were measured weekly throughout one month. RESULTS: GnRH produced a decrease in serum testosterone levels to normal values, in parallel with the suppression of serum LH and FSH concentrations. The patient was treated for three months with triptorelin and she experienced an amelioration of the hyperandrogenic symptoms. In order to achieve a diagnosis, the patient was submitted to a laparotomy that revealed a small hilus cell tumour in the left ovary. CONCLUSION: GnRH analogues may offer a good therapeutic option in some states of gonadotrophin-dependent hyperandrogenism of ovarian origin. (+info)The best correlation of the new index of hyperandrogenism with the grade of increased body hair. (8/197)
OBJECTIVE: Hyperandrogenemia is the most frequent endocrine disorder in fertile women causing a variety of negative metabolic disturbances. Establishing the diagnosis of androgen overproduction has important implications for the follow-up and treatment of patients. The aim of our study was to identify the optimal laboratory marker of androgen production by correlating the markers to the presence or grade of increased body hair as a clinical sign of hyperandrogenism. DESIGN: Prospective observational study. METHODS: A total of 62 women with acne were included into the study. The serum concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS) and sex hormone-binding globulin (SHBG) were evaluated. The index of free testosterone (IFT) and a new index of hyperandrogenism (IHA) were calculated. The monitored laboratory markers were correlated to the presence or grade of increased body hair using several statistical methods. RESULTS: The statistical significance of differences between the average levels of laboratory markers between hirsute and non-hirsute women decreased in the following order: IHA, androstenedione and DHEA. Of all the above laboratory markers, only increased IHA was present significantly more often in hirsute women. The significance of correlation between the grade of increased body hair and the tested variables decreased in the following order: IHA, IFT, DHEA, androstenedione, DHEAS and testosterone. CONCLUSIONS: The clinical marker of hyperandrogenism correlates most closely to IHA, reflecting the levels of all commonly determined androgens or androgen precursors and SHBG. Its simple calculation makes IHA a suitable tool for determining total production of androgens in clinical practice, especially in cases with borderline elevations of values. (+info)Hyperandrogenism is a medical condition characterized by excessive levels of androgens (male sex hormones) in the body. This can lead to various symptoms such as hirsutism (excessive hair growth), acne, irregular menstrual periods, and infertility in women. It can be caused by conditions like polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia, and tumors in the ovaries or adrenal glands. Proper diagnosis and management of hyperandrogenism is important to prevent complications and improve quality of life.
Polycyctic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by the presence of hyperandrogenism (excess male hormones), ovulatory dysfunction, and polycystic ovaries. The Rotterdam criteria are commonly used for diagnosis, which require at least two of the following three features:
1. Oligo- or anovulation (irregular menstrual cycles)
2. Clinical and/or biochemical signs of hyperandrogenism (e.g., hirsutism, acne, or high levels of androgens in the blood)
3. Polycystic ovaries on ultrasound examination (presence of 12 or more follicles measuring 2-9 mm in diameter, or increased ovarian volume >10 mL)
The exact cause of PCOS remains unclear, but it is believed to involve a combination of genetic and environmental factors. Insulin resistance and obesity are common findings in women with PCOS, which can contribute to the development of metabolic complications such as type 2 diabetes, dyslipidemia, and cardiovascular disease.
Management of PCOS typically involves a multidisciplinary approach that includes lifestyle modifications (diet, exercise, weight loss), medications to regulate menstrual cycles and reduce hyperandrogenism (e.g., oral contraceptives, metformin, anti-androgens), and fertility treatments if desired. Regular monitoring of metabolic parameters and long-term follow-up are essential for optimal management and prevention of complications.
Hirsutism is a medical condition characterized by excessive hair growth in women in areas where hair growth is typically androgen-dependent, such as the face, chest, lower abdomen, and inner thighs. This hair growth is often thick, dark, and coarse, resembling male-pattern hair growth. Hirsutism can be caused by various factors, including hormonal imbalances, certain medications, and genetic conditions. It's essential to consult a healthcare professional if you experience excessive or unwanted hair growth to determine the underlying cause and develop an appropriate treatment plan.
Oligomenorrhea is a medical term used to describe infrequent menstrual periods, where the cycle length is more than 35 days but less than 68 days. It's considered a menstrual disorder and can affect people of reproductive age. The causes of oligomenorrhea are varied, including hormonal imbalances, polycystic ovary syndrome (PCOS), thyroid disorders, excessive exercise, significant weight loss or gain, and stress. In some cases, it may not cause any other symptoms, but in others, it can be associated with infertility, hirsutism (excessive hair growth), acne, or obesity. Treatment depends on the underlying cause and may include lifestyle modifications, hormonal medications, or surgery in rare cases.
Acne vulgaris is a common skin condition characterized by the formation of various types of blemishes on the skin, such as blackheads, whiteheads, papules, pustules, and cysts or nodules. These lesions typically appear on areas of the body that have a high concentration of sebaceous glands, including the face, neck, chest, back, and shoulders.
Acne vulgaris occurs when hair follicles become clogged with dead skin cells and excess oil (sebum) produced by the sebaceous glands. This blockage provides an ideal environment for bacteria, particularly Propionibacterium acnes, to multiply, leading to inflammation and infection. The severity of acne vulgaris can range from mild with only a few scattered comedones (blackheads or whiteheads) to severe cystic acne, which can cause significant scarring and emotional distress.
The exact causes of acne vulgaris are not fully understood, but several factors contribute to its development, including:
1. Hormonal changes during puberty, menstruation, pregnancy, or due to conditions like polycystic ovary syndrome (PCOS)
2. Genetic predisposition
3. Use of certain medications, such as corticosteroids and lithium
4. Excessive production of sebum due to overactive sebaceous glands
5. Accumulation of dead skin cells that clog pores
6. Bacterial infection (particularly Propionibacterium acnes)
7. Inflammation caused by the body's immune response to bacterial infection and clogged pores
Treatment for acne vulgaris depends on its severity and can include over-the-counter or prescription topical treatments, oral medications, chemical peels, light therapies, or even hormonal therapies in some cases. It is essential to seek professional medical advice from a dermatologist or healthcare provider to determine the most appropriate treatment plan for individual needs.
Virilism is a condition that results from excessive exposure to androgens (male hormones) such as testosterone. It can occur in both males and females, but it is more noticeable in women and children. In females, virilism can cause various masculinizing features like excess body hair, deepened voice, enlarged clitoris, and irregular menstrual cycles. In children, it can lead to premature puberty and growth abnormalities. Virilism is often caused by conditions that involve the adrenal glands or ovaries, including tumors, congenital adrenal hyperplasia, and certain medications.
Nafarelin is a synthetic decapeptide analog of the natural gonadotropin-releasing hormone (GnRH). It is primarily used as a nasal spray for the treatment of central precocious puberty in children and endometriosis in adults.
In medical terms, Nafarelin is defined as:
A synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) used in the treatment of central precocious puberty and endometriosis. It acts as a potent agonist of GnRH receptors, leading to an initial increase in the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), followed by downregulation of these receptors and a decrease in FSH and LH secretion. This results in decreased gonadal steroid production, including estrogen and testosterone, which helps to control the symptoms of central precocious puberty and endometriosis.
Nafarelin is available under the brand name Synarel and is administered as a nasal spray. It is important to note that Nafarelin can cause side effects such as hot flashes, headaches, and mood changes, and it may also affect bone growth in children with central precocious puberty. Therefore, it should be used under the close supervision of a healthcare provider.
Androgens are a class of hormones that are primarily responsible for the development and maintenance of male sexual characteristics and reproductive function. Testosterone is the most well-known androgen, but other androgens include dehydroepiandrosterone (DHEA), androstenedione, and dihydrotestosterone (DHT).
Androgens are produced primarily by the testes in men and the ovaries in women, although small amounts are also produced by the adrenal glands in both sexes. They play a critical role in the development of male secondary sexual characteristics during puberty, such as the growth of facial hair, deepening of the voice, and increased muscle mass.
In addition to their role in sexual development and function, androgens also have important effects on bone density, mood, and cognitive function. Abnormal levels of androgens can contribute to a variety of medical conditions, including infertility, erectile dysfunction, acne, hirsutism (excessive hair growth), and prostate cancer.
Testosterone is a steroid hormone that belongs to androsten class of hormones. It is primarily secreted by the Leydig cells in the testes of males and, to a lesser extent, by the ovaries and adrenal glands in females. Testosterone is the main male sex hormone and anabolic steroid. It plays a key role in the development of masculine characteristics, such as body hair and muscle mass, and contributes to bone density, fat distribution, red cell production, and sex drive. In females, testosterone contributes to sexual desire and bone health. Testosterone is synthesized from cholesterol and its production is regulated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Acanthosis nigricans is a medical condition characterized by the darkening and thickening of the skin in certain areas of the body. These areas typically include the back of the neck, armpits, groin, and skin folds. The skin becomes velvety to touch, and may have a "dirty" appearance.
The condition is often associated with insulin resistance, which can be a sign of type 2 diabetes or prediabetes. It can also be linked to obesity, hormonal imbalances, certain medications, and some rare genetic syndromes.
In addition to the changes in skin color and texture, people with acanthosis nigricans may also experience itching, odor, or discomfort in the affected areas. Treatment typically involves addressing the underlying cause of the condition, such as managing diabetes or losing weight. Topical treatments may also be used to improve the appearance of the skin.
17-α-Hydroxyprogesterone is a naturally occurring hormone produced by the adrenal glands and, in smaller amounts, by the ovaries and testes. It is an intermediate in the biosynthesis of steroid hormones, including cortisol, aldosterone, and sex hormones such as testosterone and estrogen.
In a medical context, 17-α-Hydroxyprogesterone may also refer to a synthetic form of this hormone that is used in the treatment of certain medical conditions. For example, a medication called 17-alpha-hydroxyprogesterone caproate (17-OHP) is used to reduce the risk of preterm birth in women who have previously given birth prematurely. It works by suppressing uterine contractions and promoting fetal lung maturity.
It's important to note that 17-alpha-Hydroxyprogesterone should only be used under the supervision of a healthcare provider, as it can have side effects and may interact with other medications.
Androstenedione is a steroid hormone produced by the adrenal glands, ovaries, and testes. It is a precursor to both male and female sex hormones, including testosterone and estrogen. In the adrenal glands, it is produced from cholesterol through a series of biochemical reactions involving several enzymes. Androstenedione can also be converted into other steroid hormones, such as dehydroepiandrosterone (DHEA) and estrone.
In the body, androstenedione plays an important role in the development and maintenance of secondary sexual characteristics, such as facial hair and a deep voice in men, and breast development and menstrual cycles in women. It also contributes to bone density, muscle mass, and overall physical strength.
Androstenedione is available as a dietary supplement and has been marketed as a way to boost athletic performance and increase muscle mass. However, its effectiveness for these purposes is not supported by scientific evidence, and it may have harmful side effects when taken in high doses or for extended periods of time. Additionally, the use of androstenedione as a dietary supplement is banned by many sports organizations, including the International Olympic Committee and the National Collegiate Athletic Association.
Menstruation disturbances, also known as menstrual disorders, refer to any irregularities or abnormalities in a woman's menstrual cycle. These disturbances can manifest in various ways, including:
1. Amenorrhea: The absence of menstrual periods for three consecutive cycles or more in women of reproductive age.
2. Oligomenorrhea: Infrequent or light menstrual periods that occur at intervals greater than 35 days.
3. Dysmenorrhea: Painful menstruation, often accompanied by cramping, pelvic pain, and other symptoms that can interfere with daily activities.
4. Menorrhagia: Heavy or prolonged menstrual periods that last longer than seven days or result in excessive blood loss, leading to anemia or other health complications.
5. Polymenorrhea: Abnormally frequent menstrual periods that occur at intervals of 21 days or less.
6. Metrorrhagia: Irregular and unpredictable vaginal bleeding between expected menstrual periods, which can be caused by various factors such as hormonal imbalances, infections, or structural abnormalities.
Menstruation disturbances can have significant impacts on a woman's quality of life, fertility, and overall health. They may result from various underlying conditions, including hormonal imbalances, polycystic ovary syndrome (PCOS), thyroid disorders, uterine fibroids, endometriosis, or sexually transmitted infections. Proper diagnosis and treatment of the underlying cause are essential for managing menstruation disturbances effectively.
Acneiform eruptions refer to skin conditions that resemble or mimic the appearance of acne vulgaris. These eruptions are characterized by the presence of papules, pustules, and comedones on the skin. However, acneiform eruptions are not true acne and can be caused by various factors such as medications, infections, or underlying medical conditions.
Some examples of acneiform eruptions include:
* Drug-induced acne: Certain medications such as corticosteroids, lithium, and antiepileptic drugs can cause an acne-like rash as a side effect.
* Rosacea: A chronic skin condition that causes redness, flushing, and pimple-like bumps on the face.
* Pseudofolliculitis barbae: A condition that occurs when curly hair grows back into the skin after shaving, causing inflammation and acne-like lesions.
* Gram-negative folliculitis: A bacterial infection that can occur as a complication of long-term antibiotic use for acne treatment.
It is important to distinguish acneiform eruptions from true acne vulgaris, as the treatment approach may differ depending on the underlying cause. Dermatologists or healthcare providers specializing in skin conditions can provide an accurate diagnosis and recommend appropriate treatment options.
Dehydroepiandrosterone sulfate (DHEA-S) is a steroid hormone that is produced by the adrenal glands. It is a modified form of dehydroepiandrosterone (DHEA), which is converted to DHEA-S in the body for storage and later conversion back to DHEA or other steroid hormones, such as testosterone and estrogen. DHEA-S is often measured in the blood as a marker of adrenal function. It is also available as a dietary supplement, although its effectiveness for any medical purpose is not well established.
Precocious puberty is a medical condition where the onset of sexual maturation occurs at an unusually early age, typically before the age of 8 in girls and before the age of 9 in boys. It is characterized by the development of secondary sexual characteristics such as breast development or growth of facial hair, as well as the start of menstruation in girls. This condition can be caused by various factors including central nervous system abnormalities, genetic disorders, or exposure to certain hormones. Early diagnosis and treatment are important to prevent potential negative effects on growth, bone health, and psychosocial development.
Congenital Adrenal Hyperplasia (CAH) is a group of inherited genetic disorders that affect the adrenal glands, which are triangular-shaped glands located on top of the kidneys. The adrenal glands are responsible for producing several essential hormones, including cortisol, aldosterone, and androgens.
CAH is caused by mutations in genes that code for enzymes involved in the synthesis of these hormones. The most common form of CAH is 21-hydroxylase deficiency, which affects approximately 90% to 95% of all cases. Other less common forms of CAH include 11-beta-hydroxylase deficiency and 3-beta-hydroxysteroid dehydrogenase deficiency.
The severity of the disorder can vary widely, depending on the degree of enzyme deficiency. In severe cases, the lack of cortisol production can lead to life-threatening salt wasting and electrolyte imbalances in newborns. The excess androgens produced due to the enzyme deficiency can also cause virilization, or masculinization, of female fetuses, leading to ambiguous genitalia at birth.
In milder forms of CAH, symptoms may not appear until later in childhood or even adulthood. These may include early puberty, rapid growth followed by premature fusion of the growth plates and short stature, acne, excessive hair growth, irregular menstrual periods, and infertility.
Treatment for CAH typically involves replacing the missing hormones with medications such as hydrocortisone, fludrocortisone, and/or sex hormones. Regular monitoring of hormone levels and careful management of medication doses is essential to prevent complications such as adrenal crisis, growth suppression, and osteoporosis.
In severe cases of CAH, early diagnosis and treatment can help prevent or minimize the risk of serious health problems and improve quality of life. Genetic counseling may also be recommended for affected individuals and their families to discuss the risks of passing on the disorder to future generations.
A luteoma is a benign ovarian tumor that is composed of luteinized cells, which are typically found in the corpus luteum of the ovary. The corpus luteum is a temporary endocrine structure that forms during the menstrual cycle and produces progesterone to support pregnancy.
Luteomas are rare tumors that usually occur in women of reproductive age, particularly those who have used fertility drugs or who have had prolonged exposure to high levels of estrogen. They can be asymptomatic or may cause symptoms such as abdominal pain, bloating, and menstrual irregularities.
Luteomas are typically diagnosed through imaging studies such as ultrasound or CT scan, and the diagnosis is confirmed through biopsy or surgical removal of the tumor. Treatment usually involves surgical removal of the tumor, and the prognosis is generally good, with a low risk of recurrence. However, luteomas can produce high levels of hormones that may cause virilization or other endocrine abnormalities, so follow-up care is important to monitor for any potential complications.
Sex Hormone-Binding Globulin (SHBG) is a protein produced mainly in the liver that plays a crucial role in regulating the active forms of the sex hormones, testosterone and estradiol, in the body. SHBG binds to these hormones in the bloodstream, creating a reservoir of bound hormones. Only the unbound (or "free") fraction of testosterone and estradiol is considered biologically active and can easily enter cells to exert its effects.
By binding to sex hormones, SHBG helps control their availability and transport in the body. Factors such as age, sex, infection with certain viruses (like hepatitis or HIV), liver disease, obesity, and various medications can influence SHBG levels and, consequently, impact the amount of free testosterone and estradiol in circulation.
SHBG is an essential factor in maintaining hormonal balance and has implications for several physiological processes, including sexual development, reproduction, bone health, muscle mass, and overall well-being. Abnormal SHBG levels can contribute to various medical conditions, such as hypogonadism (low testosterone levels), polycystic ovary syndrome (PCOS), and certain types of cancer.
Anti-Mullerian Hormone (AMH) is a glycoprotein hormone that belongs to the transforming growth factor-beta (TGF-β) family. It is primarily produced by the granulosa cells of developing follicles in the ovaries of females. AMH plays an essential role in female reproductive physiology, as it inhibits the recruitment and further development of primordial follicles, thereby regulating the size of the primordial follicle pool and the onset of puberty.
AMH levels are often used as a biomarker for ovarian reserve assessment in women. High AMH levels indicate a larger ovarian reserve, while low levels suggest a decreased reserve, which may be associated with reduced fertility or an earlier onset of menopause. Additionally, measuring AMH levels can help predict the response to ovarian stimulation during assisted reproductive technologies (ART) such as in vitro fertilization (IVF).
A neoplasm of gonadal tissue refers to an abnormal growth or tumor that develops in the reproductive organs, specifically the ovaries in women and the testes in men. These tumors can be benign (non-cancerous) or malignant (cancerous), and their growth can interfere with the normal function of the gonads.
Gonadal tissue neoplasms can have various causes, including genetic mutations, environmental factors, and hormonal imbalances. The symptoms of these tumors may vary depending on their size, location, and type, but they can include pelvic pain, bloating, abnormal menstruation, or a palpable mass in the affected area.
It is essential to diagnose and treat gonadal tissue neoplasms as early as possible to prevent complications such as infertility, metastasis, or death. Diagnostic procedures may include imaging tests, blood tests, and biopsies, while treatment options may include surgery, radiation therapy, chemotherapy, or hormone therapy.
An ovary is a part of the female reproductive system in which ova or eggs are produced through the process of oogenesis. They are a pair of solid, almond-shaped structures located one on each side of the uterus within the pelvic cavity. Each ovary measures about 3 to 5 centimeters in length and weighs around 14 grams.
The ovaries have two main functions: endocrine (hormonal) function and reproductive function. They produce and release eggs (ovulation) responsible for potential fertilization and development of an embryo/fetus during pregnancy. Additionally, they are essential in the production of female sex hormones, primarily estrogen and progesterone, which regulate menstrual cycles, sexual development, and reproduction.
During each menstrual cycle, a mature egg is released from one of the ovaries into the fallopian tube, where it may be fertilized by sperm. If not fertilized, the egg, along with the uterine lining, will be shed, leading to menstruation.
Dehydroepiandrosterone (DHEA) is a steroid hormone produced by the adrenal glands. It serves as a precursor to other hormones, including androgens such as testosterone and estrogens such as estradiol. DHEA levels typically peak during early adulthood and then gradually decline with age.
DHEA has been studied for its potential effects on various health conditions, including aging, cognitive function, sexual dysfunction, and certain chronic diseases. However, the evidence supporting its use for these purposes is generally limited and inconclusive. As with any supplement or medication, it's important to consult with a healthcare provider before taking DHEA to ensure safety and effectiveness.
Anovulation is a medical condition in which there is a failure to ovulate, or release a mature egg from the ovaries, during a menstrual cycle. This can occur due to various reasons such as hormonal imbalances, polycystic ovary syndrome (PCOS), premature ovarian failure, excessive exercise, stress, low body weight, or certain medications. Anovulation is common in women with irregular menstrual cycles and can cause infertility if left untreated. In some cases, anovulation may be treated with medication to stimulate ovulation.
Metformin is a type of biguanide antihyperglycemic agent used primarily in the treatment of type 2 diabetes mellitus. It works by decreasing glucose production in the liver, reducing glucose absorption in the gut, and increasing insulin sensitivity in muscle and fat tissue. By lowering both basal and postprandial plasma glucose levels, metformin helps to control blood sugar levels and improve glycemic control. It is also used off-label for various other indications such as polycystic ovary syndrome (PCOS) and gestational diabetes. Common side effects include diarrhea, nausea, vomiting, and abdominal discomfort. Lactic acidosis is a rare but serious side effect that requires immediate medical attention.
Insulin resistance is a condition in which the body's cells become less responsive to insulin, a hormone produced by the pancreas that regulates blood sugar levels. In response to this decreased sensitivity, the pancreas produces more insulin to help glucose enter the cells. However, over time, the pancreas may not be able to keep up with the increased demand for insulin, leading to high levels of glucose in the blood and potentially resulting in type 2 diabetes, prediabetes, or other health issues such as metabolic syndrome, cardiovascular disease, and non-alcoholic fatty liver disease. Insulin resistance is often associated with obesity, physical inactivity, and genetic factors.
Adrenal gland diseases refer to a group of medical conditions that affect the function or structure of the adrenal glands. The adrenal glands are small, triangular-shaped glands located on top of each kidney. They are responsible for producing several essential hormones, including cortisol, aldosterone, and adrenaline (epinephrine).
There are various types of adrenal gland diseases, some of which include:
1. Adrenal Insufficiency: A condition where the adrenal glands do not produce enough hormones, particularly cortisol and aldosterone. This can lead to symptoms such as fatigue, weight loss, low blood pressure, and skin hyperpigmentation.
2. Cushing's Syndrome: A condition characterized by an excess of cortisol in the body. It can be caused by a tumor in the pituitary gland or adrenal glands, or it can result from long-term use of steroid medications.
3. Adrenal Cancer: A rare type of cancer that affects the adrenal glands. Symptoms may include abdominal pain, weight loss, and high blood pressure.
4. Pheochromocytoma: A tumor that develops in the adrenal glands and causes an overproduction of adrenaline (epinephrine) and noradrenaline (norepinephrine). Symptoms may include high blood pressure, headaches, sweating, and anxiety.
5. Adrenal Hemorrhage: A condition where bleeding occurs in the adrenal glands, often as a result of severe trauma or infection. This can lead to adrenal insufficiency and other complications.
6. Congenital Adrenal Hyperplasia: An inherited disorder that affects the production of cortisol and other hormones in the adrenal glands. Symptoms may include ambiguous genitalia, precocious puberty, and short stature.
Treatment for adrenal gland diseases varies depending on the specific condition and its severity. Treatment options may include medication, surgery, or radiation therapy.
Hyperinsulinism is a medical condition characterized by an excess production and release of insulin from the pancreas. Insulin is a hormone that helps regulate blood sugar levels by allowing cells in the body to take in sugar (glucose) for energy or storage. In hyperinsulinism, the increased insulin levels can cause low blood sugar (hypoglycemia), which can lead to symptoms such as sweating, shaking, confusion, and in severe cases, seizures or loss of consciousness.
There are several types of hyperinsulinism, including congenital forms that are present at birth and acquired forms that develop later in life. Congenital hyperinsulinism is often caused by genetic mutations that affect the way insulin is produced or released from the pancreas. Acquired hyperinsulinism can be caused by factors such as certain medications, hormonal disorders, or tumors of the pancreas.
Treatment for hyperinsulinism depends on the underlying cause and severity of the condition. Treatment options may include dietary changes, medication to reduce insulin secretion, or surgery to remove part or all of the pancreas.
Amenorrhea is a medical condition characterized by the absence or cessation of menstrual periods in women of reproductive age. It can be categorized as primary amenorrhea, when a woman who has not yet had her first period at the expected age (usually around 16 years old), or secondary amenorrhea, when a woman who has previously had regular periods stops getting them for six months or more.
There are various causes of amenorrhea, including hormonal imbalances, pregnancy, breastfeeding, menopause, extreme weight loss or gain, eating disorders, intense exercise, stress, chronic illness, tumors, and certain medications or medical treatments. In some cases, amenorrhea may indicate an underlying medical condition that requires further evaluation and treatment.
Amenorrhea can have significant impacts on a woman's health and quality of life, including infertility, bone loss, and emotional distress. Therefore, it is essential to consult with a healthcare provider if you experience amenorrhea or missed periods to determine the underlying cause and develop an appropriate treatment plan.
Luteinizing Hormone (LH) is a glycoprotein hormone, which is primarily produced and released by the anterior pituitary gland. In women, a surge of LH triggers ovulation, the release of an egg from the ovaries during the menstrual cycle. During pregnancy, LH stimulates the corpus luteum to produce progesterone. In men, LH stimulates the testes to produce testosterone. It plays a crucial role in sexual development, reproduction, and maintaining the reproductive system.
Alopecia is a medical term that refers to the loss of hair or baldness. It can occur in various parts of the body, but it's most commonly used to describe hair loss from the scalp. Alopecia can have several causes, including genetics, hormonal changes, medical conditions, and aging.
There are different types of alopecia, such as:
* Alopecia Areata: It is a condition that causes round patches of hair loss on the scalp or other parts of the body. The immune system attacks the hair follicles, causing the hair to fall out.
* Androgenetic Alopecia: Also known as male pattern baldness or female pattern baldness, it's a genetic condition that causes gradual hair thinning and eventual hair loss, typically following a specific pattern.
* Telogen Effluvium: It is a temporary hair loss condition caused by stress, medication, pregnancy, or other factors that can cause the hair follicles to enter a resting phase, leading to shedding and thinning of the hair.
The treatment for alopecia depends on the underlying cause. In some cases, such as with telogen effluvium, hair growth may resume without any treatment. However, other forms of alopecia may require medical intervention, including topical treatments, oral medications, or even hair transplant surgery in severe cases.
Flutamide is an anti-androgen medication, which is primarily used to treat prostate cancer. It works by blocking the action of androgens (male hormones), such as testosterone, on cancer cells. This helps to slow down or stop the growth of prostate cancer cells. Flutamide may be given in combination with other medications, such as a luteinizing hormone-releasing hormone (LHRH) agonist, to enhance its effectiveness. It is usually taken by mouth in the form of tablets.
Flutamide can have side effects, including breast tenderness and enlargement, hot flashes, nausea, vomiting, diarrhea, and loss of sexual desire. In rare cases, it may cause more serious side effects such as liver damage. It is important to be monitored by a healthcare professional while taking this medication to ensure that it is working properly and to manage any potential side effects.
Steroid 17-alpha-hydroxylase, also known as CYP17A1, is a cytochrome P450 enzyme that plays a crucial role in steroid hormone biosynthesis. It is located in the endoplasmic reticulum of cells in the adrenal glands and gonads. This enzyme catalyzes the 17-alpha-hydroxylation and subsequent lyase cleavage of pregnenolone and progesterone, converting them into dehydroepiandrosterone (DHEA) and androstenedione, respectively. These steroid intermediates are essential for the biosynthesis of both glucocorticoids and sex steroids, including cortisol, aldosterone, estrogens, and testosterone.
Defects in the CYP17A1 gene can lead to several disorders, such as congenital adrenal hyperplasia (CAH) due to 17-alpha-hydroxylase deficiency, which is characterized by decreased production of cortisol and sex steroids and increased mineralocorticoid levels. This condition results in sexual infantilism, electrolyte imbalances, and hypertension.
Hormones are defined as chemical messengers that are produced by endocrine glands or specialized cells and are transported through the bloodstream to tissues and organs, where they elicit specific responses. They play crucial roles in regulating various physiological processes such as growth, development, metabolism, reproduction, and mood. Examples of hormones include insulin, estrogen, testosterone, adrenaline, and thyroxine.
The menstrual cycle is a series of natural changes that occur in the female reproductive system over an approximate 28-day interval, marking the body's preparation for potential pregnancy. It involves the interplay of hormones that regulate the growth and disintegration of the uterine lining (endometrium) and the release of an egg (ovulation) from the ovaries.
The menstrual cycle can be divided into three main phases:
1. Menstrual phase: The cycle begins with the onset of menstruation, where the thickened uterine lining is shed through the vagina, lasting typically for 3-7 days. This shedding occurs due to a decrease in estrogen and progesterone levels, which are hormones essential for maintaining the endometrium during the previous cycle.
2. Follicular phase: After menstruation, the follicular phase commences with the pituitary gland releasing follicle-stimulating hormone (FSH). FSH stimulates the growth of several ovarian follicles, each containing an immature egg. One dominant follicle usually becomes selected to mature and release an egg during ovulation. Estrogen levels rise as the dominant follicle grows, causing the endometrium to thicken in preparation for a potential pregnancy.
3. Luteal phase: Following ovulation, the ruptured follicle transforms into the corpus luteum, which produces progesterone and estrogen to further support the endometrial thickening. If fertilization does not occur within approximately 24 hours after ovulation, the corpus luteum will degenerate, leading to a decline in hormone levels. This drop triggers the onset of menstruation, initiating a new menstrual cycle.
Understanding the menstrual cycle is crucial for monitoring reproductive health and planning or preventing pregnancies. Variations in cycle length and symptoms are common among women, but persistent irregularities may indicate underlying medical conditions requiring further evaluation by a healthcare professional.
Theca cells are specialized cells that are part of the follicle where the egg matures in the ovary. They are located in the outer layer of the follicle and play an important role in producing hormones necessary for the growth and development of the follicle and the egg within it. Specifically, they produce androgens, such as testosterone, which are then converted into estrogens by another type of cells in the follicle called granulosa cells. These hormones help to thicken the lining of the uterus in preparation for a possible pregnancy. In some cases, theca cells can become overactive and produce too much testosterone, leading to conditions such as polycystic ovary syndrome (PCOS).
Menarche is the first occurrence of menstruation in a female adolescent, indicating the onset of reproductive capability. It usually happens between the ages of 10 and 16, with an average age of around 12-13 years old, but it can vary widely from one individual to another due to various factors such as genetics, nutrition, and overall health.
Achieving menarche is a significant milestone in a girl's life, signaling the transition from childhood to adolescence. It is also an essential indicator of sexual maturation, often used in conjunction with other physical changes to assess pubertal development. However, it does not necessarily mean that a girl is psychologically or emotionally prepared for menstruation and sexual activity; therefore, appropriate education and support are crucial during this period.
Insulin is a hormone produced by the beta cells of the pancreatic islets, primarily in response to elevated levels of glucose in the circulating blood. It plays a crucial role in regulating blood glucose levels and facilitating the uptake and utilization of glucose by peripheral tissues, such as muscle and adipose tissue, for energy production and storage. Insulin also inhibits glucose production in the liver and promotes the storage of excess glucose as glycogen or triglycerides.
Deficiency in insulin secretion or action leads to impaired glucose regulation and can result in conditions such as diabetes mellitus, characterized by chronic hyperglycemia and associated complications. Exogenous insulin is used as a replacement therapy in individuals with diabetes to help manage their blood glucose levels and prevent long-term complications.
Follicle-Stimulating Hormone (FSH) is a glycoprotein hormone secreted and released by the anterior pituitary gland. In females, it promotes the growth and development of ovarian follicles in the ovary, which ultimately leads to the maturation and release of an egg (ovulation). In males, FSH stimulates the testes to produce sperm. It works in conjunction with luteinizing hormone (LH) to regulate reproductive processes. The secretion of FSH is controlled by the hypothalamic-pituitary-gonadal axis and its release is influenced by the levels of gonadotropin-releasing hormone (GnRH), estrogen, inhibin, and androgens.
Obesity is a complex disease characterized by an excess accumulation of body fat to the extent that it negatively impacts health. It's typically defined using Body Mass Index (BMI), a measure calculated from a person's weight and height. A BMI of 30 or higher is indicative of obesity. However, it's important to note that while BMI can be a useful tool for identifying obesity in populations, it does not directly measure body fat and may not accurately reflect health status in individuals. Other factors such as waist circumference, blood pressure, cholesterol levels, and blood sugar levels should also be considered when assessing health risks associated with weight.
A Glucose Tolerance Test (GTT) is a medical test used to diagnose prediabetes, type 2 diabetes, and gestational diabetes. It measures how well your body is able to process glucose, which is a type of sugar.
During the test, you will be asked to fast (not eat or drink anything except water) for at least eight hours before the test. Then, a healthcare professional will take a blood sample to measure your fasting blood sugar level. After that, you will be given a sugary drink containing a specific amount of glucose. Your blood sugar levels will be measured again after two hours and sometimes also after one hour.
The results of the test will indicate how well your body is able to process the glucose and whether you have normal, impaired, or diabetic glucose tolerance. If your blood sugar levels are higher than normal but not high enough to be diagnosed with diabetes, you may have prediabetes, which means that you are at increased risk of developing type 2 diabetes in the future.
It is important to note that a Glucose Tolerance Test should be performed under the supervision of a healthcare professional, as high blood sugar levels can be dangerous if not properly managed.
The adrenal glands are a pair of endocrine glands that are located on top of the kidneys. Each gland has two parts: the outer cortex and the inner medulla. The adrenal cortex produces hormones such as cortisol, aldosterone, and androgens, which regulate metabolism, blood pressure, and other vital functions. The adrenal medulla produces catecholamines, including epinephrine (adrenaline) and norepinephrine (noradrenaline), which help the body respond to stress by increasing heart rate, blood pressure, and alertness.
Androgen antagonists are a class of drugs that block the action of androgens, which are hormones that contribute to male sexual development and characteristics. They work by binding to androgen receptors in cells, preventing the natural androgens from attaching and exerting their effects. This can be useful in treating conditions that are caused or worsened by androgens, such as prostate cancer, hirsutism (excessive hair growth in women), and acne. Examples of androgen antagonists include flutamide, bicalutamide, and spironolactone.
Body Mass Index (BMI) is a measure used to assess whether a person has a healthy weight for their height. It's calculated by dividing a person's weight in kilograms by the square of their height in meters. Here is the medical definition:
Body Mass Index (BMI) = weight(kg) / [height(m)]^2
According to the World Health Organization, BMI categories are defined as follows:
* Less than 18.5: Underweight
* 18.5-24.9: Normal or healthy weight
* 25.0-29.9: Overweight
* 30.0 and above: Obese
It is important to note that while BMI can be a useful tool for identifying weight issues in populations, it does have limitations when applied to individuals. For example, it may not accurately reflect body fat distribution or muscle mass, which can affect health risks associated with excess weight. Therefore, BMI should be used as one of several factors when evaluating an individual's health status and risk for chronic diseases.
Steroids, also known as corticosteroids, are a type of hormone that the adrenal gland produces in your body. They have many functions, such as controlling the balance of salt and water in your body and helping to reduce inflammation. Steroids can also be synthetically produced and used as medications to treat a variety of conditions, including allergies, asthma, skin conditions, and autoimmune disorders.
Steroid medications are available in various forms, such as oral pills, injections, creams, and inhalers. They work by mimicking the effects of natural hormones produced by your body, reducing inflammation and suppressing the immune system's response to prevent or reduce symptoms. However, long-term use of steroids can have significant side effects, including weight gain, high blood pressure, osteoporosis, and increased risk of infections.
It is important to note that anabolic steroids are a different class of drugs that are sometimes abused for their muscle-building properties. These steroids are synthetic versions of the male hormone testosterone and can have serious health consequences when taken in large doses or without medical supervision.
Hyperandrogenism
Polycystic ovary syndrome
Vaginal atresia
Cyproterone acetate
List of OMIM disorder codes
Dihydrotestosterone
Androstanedione
Antiandrogen
WNT4 deficiency
Sex-determining region Y protein
Court of Arbitration for Sport
Sex verification in sports
Caster Semenya
Adrenocortical adenoma
Flutamide
Spondyloepimetaphyseal dysplasia, Pakistani type
Feminizing hormone therapy
Libido
HAIR-AN syndrome
Androgen deficiency
Late onset congenital adrenal hyperplasia
Gonadotropin-releasing hormone agonist
Cortisone reductase deficiency
Obesity and fertility
Testosterone
Functional hypothalamic amenorrhea
Morgan Carpenter
SAHA syndrome
Pharmacokinetics of testosterone
Cimetidine
Hyperandrogenism - Wikipedia
Müllerian aplasia and hyperandrogenism: MedlinePlus Genetics
IAAF's Hyperandrogenism policy attracts IWG's wrath | Sunday Standard
Asser International Sports Law Blog | All posts tagged 'Hyperandrogenism'
Asser International Sports Law Blog | All posts tagged 'Hyperandrogenism'
Postmenopausal women with hyperandrogenism: case reports of three patients | ECE2016 | 18th European Congress of Endocrinology ...
Effect of berberine on hyperandrogenemia, ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome ...
PCOS, acne, and acne treatment: What to know
Hyperandrogenism in Athletics
Hyperadrenocorticism/Hyperandrogenism - Vetacademy
hyperandrogenism - The Curbsiders
Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism - [scite report]
Why Caster Semenya and Dutee Chand deserve to compete at Rio 2016
Fertility Treatment for Hyperandrogenism - Houston, TX
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G...
The treatment of hyperandrogenism with oral contraceptives<...
Candidate gene analysis in premature pubarche and adolescent hyperandrogenism. | Profiles RNS
Why Caster Semenya and Dutee Chand deserve to compete (and win) at Rio 2016
Diagnosis of hyperandrogenism: clinical criteria as a source of information in Wikipedia
hyperandrogenism found 1 record - Provincial Hospitals Library Catalogue - Nova Scotia Health Authority
topic:"Hyperandrogenism" found 1 record - Provincial Hospitals Library Catalogue - Nova Scotia Health Authority
Women's Health - Whole Health Library
Hirsutism: Causes and Symptoms
Generalized Lipodystrophy: Practice Essentials, Pathophysiology, Lipoatrophic Diabetes
Nutrients | Free Full-Text | Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition...
Impact of EA and physical exercise on hyperandrogenism and oligo/amenorrhea in women with PCOS. - Acupuncture Pregnancy Clinic
Nord Open Research Archive: Maternal hyperandrogenism is associated with a higher risk of type 2 diabetes mellitus and...
The impact of hyperandrogenism in female obesity and cardiometabolic diseases associated with polycystic ovary syndrome - WRAP...
Contribuição das características clínicas, hormonais e radiológicas para o diagnóstico...
PCOS15
- To study the effect of berberine (BBR) on hyperandrogenemia (HA), ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome (PCOS). (ajol.info)
- Berberine lowers the weight of PCOS mice, mitigates hyperandrogenemia and inflammatory state, and enhances recovery of ovulation. (ajol.info)
- Excess androgen production, or hyperandrogenism, is a defining feature of PCOS. (medicalnewstoday.com)
- One of the primary causes of hyperandrogenism is polycystic ovarian syndrome (PCOS), the development of cysts on the ovaries as a result of malfunctioning ovarian follicles. (infertilityivfhouston.com)
- Women diagnosed with PCOS or hyperandrogenism who are also overweight are first encouraged to achieve a healthy weight before beginning fertility treatment. (infertilityivfhouston.com)
- This procedure has proven successful for women with hyperandrogenism, PCOS, or other ovulation disorders. (infertilityivfhouston.com)
- Polycystic ovarian syndrome (PCOS) is a clinical diagnosis characterized by oligoovulation, hyperandrogenism, and often the presence of polycystic ovaries. (va.gov)
- Impact of EA and physical exercise on hyperandrogenism and oligo/amenorrhea in women with PCOS. (acupuncturepregnancy.com.au)
- The Rotterdam diagnostic criteria have also introduced two new phenotypic subgroups (including normoandrogenemic women with PCOS) that have provided novel insights into a potential role for hyperandrogenism in the development of adverse cardiometabolic risk in women with PCOS. (warwick.ac.uk)
- Supplements of resveratrol may reverse the hyperandrogenemia and hyperinsulinemia associated with polycystic ovary syndrome (PCOS), a new study suggests. (medscape.com)
- Based on these observations, he and his colleagues hypothesized that resveratrol might relieve the hyperandrogenism seen in patients with PCOS. (medscape.com)
- It seems that women with PCOS are especially vulnerable to developing a fatty liver - especially if they also have hyperandrogenism. (liversupport.com)
- About 80 percent of women with PCOS have hyperandrogenism. (science20.com)
- Calculated free testosterone, free androgen index, or calculated bioavailable testosterone should be used to assess biochemical hyperandrogenism in the diagnosis of PCOS. (medscape.com)
- Other signs of hyperandrogenism (eg, clitoromegaly, increased muscle mass, voice deepening) are more characteristic of an extreme form of PCOS termed hyperthecosis. (medscape.com)
Symptoms of hyperandrogenism4
- Symptoms of hyperandrogenism may include acne, seborrhea (inflamed skin), hair loss on the scalp, increased body or facial hair, and infrequent or absent menstruation. (wikipedia.org)
- Symptoms of hyperandrogenism can be treated with birth control pills or antiandrogens, such as cyproterone acetate or spironolactone. (wikipedia.org)
- Because hyperandrogenism is characterized by elevated male sex hormone levels, symptoms of hyperandrogenism in men are often negligible. (wikipedia.org)
- Elevated androstenedione levels may cause symptoms of hyperandrogenism in females. (cdc.gov)
Androgens6
- Hyperandrogenism is a medical condition characterized by high levels of androgens. (wikipedia.org)
- Hyperandrogenism can affect both men and women but is more noticeable in women since elevated levels of androgens in women may facilitate virilization. (wikipedia.org)
- Women with Müllerian aplasia and hyperandrogenism have higher-than-normal levels of male sex hormones called androgens in their blood (hyperandrogenism), which can cause acne and excessive facial hair (facial hirsutism). (medlineplus.gov)
- Loss of regulation by WNT4 likely disrupts development of the female reproductive system and induces abnormal production of androgens, leading to the features of Müllerian aplasia and hyperandrogenism. (medlineplus.gov)
- In particular, there is a condition called hyperandrogenism wherein females have higher levels of 'androgens,' such as testosterone. (thesportsniche.com)
- The hormonal imbalance leads to an increased production of androgens called hyperandrogenism. (pearltrees.com)
Hirsutism2
- Symptoms may include the following: Hirsutism (male-pattern hair growth) Alopecia (balding) Masculine appearance Hidradenitis suppurativa Polycystic ovarian syndrome Oligomenorrhea (menstrual irregularities) Acne Obesity Infertility Deepening of voice Oily skin Seborrhea (skin inflammation) Libido (increased sex drive) Type 2 diabetes Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. (wikipedia.org)
- Prominent signs of hyperandrogenism are hirsutism (unwanted growth of hair, especially in the abdominal region and on the back), adult acne, deepening of the voice, and alopecia (balding). (wikipedia.org)
Clinical4
- point of view, 'Diagnosis of hyperandrogenism: clinical criteria' is the 413,802nd most reliable publication with DOI number in different language versions of Wikipedia (AR-score). (bestref.net)
- This book is a practical clinical guide to the correct diagnosis and appropriate treatment of hyperandrogenism, an extremely common endocrine disease that can affect women from adolescence to menopause. (nshealth.ca)
- Clinical features and assessment of hyperandrogenism: differential diagnosis for clinical use -- 4. (nshealth.ca)
- Obtain total testosterone and dehydroepiandrosterone sulfate (DHEA-S) levels in patients with clinical hyperandrogenism and 8 AM 17-hydroxyprogesterone levels if late-onset congenital adrenal hyperplasia (CAH) is suspected. (medscape.com)
Insulin resistance2
- For example, some common pathophysiological pathways, such as hyperandrogenism or insulin resistance, may be involved. (eurekalert.org)
- Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. (nature.com)
Testosterone6
- In 2011, the International Association of Athletics Federations (now World Athletics) and IOC (International Olympic Committee) released statements restricting the eligibility of female athletes with high testosterone, whether through hyperandrogenism or as a result of a difference in sex development (DSD). (wikipedia.org)
- The IAAF's Hyperandrogenism regulations applies only on women with higher levels of testosterone and hyperandrogenic female athletes are believed to have performance advantage over other athletes. (sundaystandard.info)
- The Court of Arbitration for Sport's suspension of regulations on hyperandrogenism-a medical condition that causes an excessive amount of testosterone in the body-cleared the track for Indian sprinter Dutee Chand and other female athletes , including South Africa's Caster Semenya, to compete at the Rio Olympics this year. (newsweek.com)
- A large number of young women suffer from high testosterone levels or Hyperandrogenism, also known as excess male hormones. (medhyaherbals.com)
- It was discovered that Semenya has hyperandrogenism, which is naturally occurring excess levels of testosterone. (911weknow.com)
- This drug, which is used to treat certain types of breast cancer, blocks the conversion of testosterone into estrogen and results in a condition known as hyperandrogenism. (science20.com)
Ovarian2
- Virilizing ovarian tumors (VOT) and ovarian stromal hyperthecosis (OH) are the most common hyperandrogenism etiologies in the postmenopausal women. (usp.br)
- Due to the difficulties in establishing the differential diagnosis between VOT and OH, bilateral oophorectomy is the treatment of choice in postmenopausal women with hyperandrogenism of ovarian origin. (usp.br)
Excess2
- Hyperandrogenism is a term used to describe women who have an excess of male hormones in their body. (infertilityivfhouston.com)
- Hyperandrogenism clinically manifests as excess terminal body hair in a male distribution pattern. (medscape.com)
Females1
- Müllerian aplasia and hyperandrogenism is a condition that affects the reproductive system in females. (medlineplus.gov)
Women7
- Hyperandrogenism affects 5-10% of women of reproductive age. (wikipedia.org)
- Hyperandrogenism in women is typically diagnosed in late adolescence with a medical evaluation. (wikipedia.org)
- While hyperandrogenism in women can be caused by external factors, it can also appear spontaneously. (wikipedia.org)
- Girls with Müllerian aplasia and hyperandrogenism do not inherit the mutation from their mother, because women with this disorder cannot have children. (medlineplus.gov)
- International Association of Athletics Federations (IAAF)'s controversial Hyperandrogenism policy ÔÇô a policy which intends to force women athletes with high testerone levels to take medication to regulate the hormones ahead of competitions ÔÇô has attracted the wrath of International Working Group on Women and Sports (IWG). (sundaystandard.info)
- Based on evidence from cross-sectional and interventional studies, hyperandrogenism, obesity, and cardiometabolic risk in women appear to be linked through complex and multidirectional pathways. (warwick.ac.uk)
- Data from female-to-male transsexuals are particularly informative because these show direct effects of hyperandrogenism (induced through exogenous use of androgenic therapies) on fat distribution and cardiometabolic risk in women. (warwick.ac.uk)
Regulations1
- These regulations were referred to by both bodies as hyperandrogenism regulations and have led to athletes with DSDs being described as having hyperandrogenism. (wikipedia.org)
Irregular1
- Combined oral contraceptive pills (COCP) should be recommended to manage hyperandrogenism and/or irregular menstrual cycles. (medscape.com)
Ovary1
- Polycystic ovary syndrome accounts for about 70% of hyperandrogenism cases. (wikipedia.org)
Levels1
- If you are looking to find relief from high androgen levels (Hyperandrogenism) in a natural way, then Ayurveda can help you out. (medhyaherbals.com)
Naturally1
- and on the other hand athletes with other naturally occurring, endogenous genetic or biological variations such as hyperandrogenism are disqualified from competition on the grounds of an unfair advantage. (newsweek.com)
Occur1
- Müllerian aplasia and hyperandrogenism may occur in people with no history of the disorder in their family. (medlineplus.gov)
Premature1
- Candidate gene analysis in premature pubarche and adolescent hyperandrogenism. (ouhsc.edu)
Infertility1
- At the crossroads of fertility and metabolism: the importance of AMPK-dependent signaling in female infertility associated with hyperandrogenism. (who.int)
Typically1
- Individuals with Müllerian aplasia and hyperandrogenism typically have an underdeveloped or absent uterus and may also have abnormalities of other reproductive organs. (medlineplus.gov)
Signs3
- Signs of hyperandrogenism regressed. (endocrine-abstracts.org)
- Signs of hyperandrogenism regressed, DM2 is well controlled with metformin. (endocrine-abstracts.org)
- Ovariectomy in described cases resulted in regression of signs of hyperandrogenism. (endocrine-abstracts.org)
Treatment1
- In addition to testing, we also provide a wide range of fertility services, including fertility treatment for hyperandrogenism . (infertilityivfhouston.com)
Type1
- Hyperandrogenism has also been observed to increase insulin tolerance, which can lead to type two diabetes and dyslipidemia, such as high cholesterol. (wikipedia.org)
Hyperinsulinemia1
- Objective: This study examines whether adipose structure-functional changes exist in normal weight PCOS women and correlate with hyperandrogenism and/or hyperinsulinemia. (elsevierpure.com)
Biochemical3
- We describe an adolescent with type A IR who experienced resolution of clinical and biochemical hyperandrogenism during GnRH agonist treatment. (medscape.com)
- These criteria were recently expanded to include polycystic ovaries apparent on ultrasonography and biochemical hyperandrogenemia, but these criteria are not necessary for diagnosis. (cfp.ca)
- These features include oligomenorrhea or anovulation, clinical or biochemical hyperandrogenism and polycystic ovaries. (ukessays.com)
APLASIA AND HYPERANDROGENISM6
- Müllerian aplasia and hyperandrogenism is a condition that affects the reproductive system in females. (medlineplus.gov)
- Individuals with Müllerian aplasia and hyperandrogenism typically have an underdeveloped or absent uterus and may also have abnormalities of other reproductive organs. (medlineplus.gov)
- Mutations in the WNT4 gene cause Müllerian aplasia and hyperandrogenism. (medlineplus.gov)
- Loss of regulation by WNT4 likely disrupts development of the female reproductive system and induces abnormal production of androgens, leading to the features of Müllerian aplasia and hyperandrogenism. (medlineplus.gov)
- Girls with Müllerian aplasia and hyperandrogenism do not inherit the mutation from their mother, because women with this disorder cannot have children. (medlineplus.gov)
- Müllerian aplasia and hyperandrogenism may occur in people with no history of the disorder in their family. (medlineplus.gov)
Postmenopausal hyperandrogenism3
- 11. Diffuse stromal Leydig cell hyperplasia: a unique cause of postmenopausal hyperandrogenism and virilization. (nih.gov)
- 20. Postmenopausal hyperandrogenism. (nih.gov)
- Gonadotropin-Releasing Hormone Analogue Stimulation Test Versus Venous Sampling in Postmenopausal Hyperandrogenism. (nni.com.sg)
Clinical3
- [ 3 ] Clinical hyperandrogenism is a concern for patients, yet there are limited data on treatment options in severe IR syndromes. (medscape.com)
- This book is a practical clinical guide to the correct diagnosis and appropriate treatment of hyperandrogenism, an extremely common endocrine disease that can affect women from adolescence to menopause. (nshealth.ca)
- Clinical features and assessment of hyperandrogenism: differential diagnosis for clinical use -- 4. (nshealth.ca)
Obesity2
- It presents with mild acanthosis nigricans, severe IR, and hyperandrogenism in the absence of obesity or lipodystrophy. (medscape.com)
- As female obesity is associated with hyperandrogenism and infertility, we studied the role of SDC3 polymorphisms in female individuals undergoing diagnostics prior to infertility treatment. (nih.gov)
Polycystic Ovary Sy2
- Polycystic ovary syndrome accounts for about 70% of hyperandrogenism cases. (wikipedia.org)
- Bilateral adrenal hyperplasia as a mechanism for hyperandrogenism in women with polycystic ovary syndrome. (nih.gov)
Dutee Chand1
- In July 2014, the Sports Authority of India (SAI) confirmed that Indian sprinter, Dutee Chand, was ineligible to compete in the Commonwealth Games due to hyperandrogenism , as determined by the blood tests conducted by the SAI on the Athletics Federation of India's (AFI's) 1 request. (lawinsport.com)
Acanthosis nigricans1
- It presents after puberty with acanthosis nigricans, IR, and hyperandrogenism. (medscape.com)
Androgen levels3
- The SAI noted that they were following the IOC's and the IAAF's hyperandrogenism guidelines when testing Chand's androgen levels. (lawinsport.com)
- As of August 22, the SAI is arguing that because high androgen levels are a " biological factor " beyond the athlete's control, hyperandrogenism should not be used to determine whether a female athlete can compete. (lawinsport.com)
- Chand has yet to release a formal statement on whether she will pursue a case against IOC's and IAAF's hyperandrogenism regulations, or whether she will opt for surgery to lower her androgen levels. (lawinsport.com)
Puberty1
- Identification of this syndrome should permit monitoring for the development of hyperandrogenemia during puberty and determination of other affected family members. (utmb.edu)
GnRH2
- GnRH agonist therapy should be considered in the treatment of hyperandrogenism in severe cases of IR. (medscape.com)
- [ 4 ] Similarly, we describe an adolescent patient with type A IR who demonstrated resolution of hyperandrogenism during GnRH agonist treatment while severe IR persisted. (medscape.com)
Dysglycemia1
- Because of hyperandrogenism with severe IR, dysglycemia, and normal lipids, type A IR was considered. (medscape.com)
Diagnosis2
Dyslipidemia1
- Hyperandrogenism has also been observed to increase insulin tolerance, which can lead to type two diabetes and dyslipidemia, such as high cholesterol. (wikipedia.org)
Ineligible to compete1
- Regarding female athletes with hyperandrogenism, the IOC proposed rules that still were relatively archaic, despite noting their goals to protect women athletes, ensure fair competition, and avoid discriminatory practices by allowing female athletes with hyperandrogenism to compete in male competition if ineligible to compete in female events. (villanova.edu)
IOC's2
- The IOC's 2015 guidelines are no victory for female athletes with hyperandrogenism. (villanova.edu)
- The SAI is now advising Chand to argue her case to the Court of Arbitration for Sport (CAS) 5, aiming to change the IOC's and IAAF's guidelines on hyperandrogenism. (lawinsport.com)
Acne1
- Symptoms of hyperandrogenism may include acne, seborrhea (inflamed skin), hair loss on the scalp, increased body or facial hair, and infrequent or absent menstruation. (wikipedia.org)
Symptoms3
- Symptoms of hyperandrogenism can be treated with birth control pills or antiandrogens, such as cyproterone acetate or spironolactone. (wikipedia.org)
- Because hyperandrogenism is characterized by elevated male sex hormone levels, symptoms of hyperandrogenism in men are often negligible. (wikipedia.org)
- Elevated androstenedione levels may cause symptoms of hyperandrogenism in females. (cdc.gov)
Adolescent1
- Starting from hypothalamic pituitary gonadal axis regulation, it analyzes the characteristics and treatments of hypothalamic amenorrhea and eating disorders, as well as polycystic ovary and adolescent hyperandrogenism. (nshealth.ca)
Severe1
- 9. Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis. (nih.gov)
Female1
- 21] In trying to avoid discrimination against female athletes with hyperandrogenism by allowing these individuals to compete with men, some athletes opine the IOC sticks firmly to the traditional gender binary, thereby discriminating, ostracizing, and humiliating these athletes. (villanova.edu)
Athletes2
- In the past, the International Olympic Committee (IOC) has required that trans athletes or athletes with naturally-occurring hormonal imbalances (such as hyperandrogenism) submit to embarrassing sex tests. (villanova.edu)
- An oft-cited study describes how four athletes between 18 to 21 years of age from "rural mountainous regions of developing countries" were flagged at the 2012 Olympics because of hyperandrogenism . (lse.ac.uk)