Ilex paraguariensis
Ilex
Chlorogenic Acid
Plant Extracts
Mate consumption and the risk of squamous cell esophageal cancer in uruguay. (1/28)
A retrospective hospital-based case-control study was carried out at the Oncology Institute of Montevideo, Uruguay, to investigate the role of mate consumption in esophageal cancer risk. The study included 344 cases with squamous cell carcinoma of the esophagus and 469 controls recruited between January 1988 and August 2000. Mate consumption was significantly associated with an increased risk of developing esophageal cancer and showed a clear dose response, with a relative risk of 2.84 [95% confidence interval (CI), 1.41-5.73] for those drinking more than 1 liter/day of mate as compared with nondrinkers. Subjects who self-reported drinking mate at a very hot temperature had an almost 2-fold increase in risk [odds ratio (OR), 1.87; 95% CI, 1.17-3.00] compared with those drinking warm to hot mate, after adjusting for cumulative consumption of mate. Mate amount and temperature were observed to have independent effects and, although no departure from multiplicativity was observed between the two covariates, those drinking more than 1 liter/day of mate at a very hot temperature had a 3-fold increase in risk (OR, 2.95; 95% CI, 1.30-6.74) compared with those drinking less than 0.5 liter/day of mate at a warm to hot temperature. Subjects with high cumulative exposure to mate in the presence of low alcohol and tobacco exposures presented a lower-risk estimate (OR, 1.52; 95% CI, 0.88-2.62), whereas those with high cumulative exposures to mate, alcohol, and tobacco presented a 7-fold increase in esophageal cancer risk (OR, 7.10; 95% CI, 3.75-13.46). The population-attributable fraction as a result of mate consumption was calculated to be 53%, of which the sole effect of amount and temperature was 14.8 and 12.6% respectively, and 14.9% was attributable to high mate consumption at high temperature. (+info)Case-control study of bladder cancer and exposure to arsenic in Argentina. (2/28)
Studies have found increased bladder cancer risks associated with high levels of arsenic in drinking water, but little information exists about risks at lower concentrations. Ecologic studies in Argentina have found increased bladder cancer mortality in Cordoba Province, where some wells are contaminated with moderate arsenic concentrations. This population-based bladder cancer case-control study in two Cordoba counties recruited 114 case-control pairs, matched on age, sex, and county, during 1996-2000. Water samples, particularly from wells, were obtained from subjects' current residences and residences in the last 40 years. Statistical analyses showed no evidence of associations with exposure estimates based on arsenic concentrations in drinking water. However, when well-water consumption per se was used as the exposure measure, time-window analyses suggested that use of well water more than 50 years before interview was associated with increased bladder cancer risk. This association was limited to ever smokers (odds ratio = 2.5, 95% confidence interval: 1.1, 5.5 for 51-70 years before interview), and the possibility that this association is due to chance cannot be excluded. This study suggests lower bladder cancer risks for arsenic than predicted from other studies but adds to evidence that the latency for arsenic-induced bladder cancers may be longer than previously thought. (+info)Mate drinking during pregnancy and risk of preterm and small for gestational age birth. (3/28)
Mate, a hot infusion of Ilex paraguayensis, is a beverage largely consumed in Southeast Latin America, including during pregnancy. To assess the effect of mate drinking during pregnancy on preterm and small for gestational age (SGA) birth, a cross-sectional study was done. From January 1st to December 31st, 1993, in the first 24 h after delivery, all 5304 mothers giving birth at the hospitals in Pelotas, Southern Brazil, were interviewed and several of their characteristics were gathered. Birthweight was recorded and gestational age at birth assessed using the Dubowitz score. All 5189 single births were analyzed. The prevalence of SGA and preterm birth was 8.0 and 9.1%, respectively. Mate intake at least once a week during the entire pregnancy period was reported by approximately 68% of the mothers. Crude analyses showed a 30% increase in the risk of SGA among daily mate drinkers compared with nonconsumers (prevalence ratio = 1.3; 95% CI 1.1-1.6), whereas no statistical association was detected with preterm births. After controlling for confounders, the significance of the association with SGA birth no longer held and the lack of association with prematurity remained unchanged. In conclusion, prevalence of daily mate drinking was high among pregnant women and, contrary to the hypothesis, no harmful effect on intrauterine growth or duration of pregnancy was detected. (+info)Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking mate in healthy subjects from Rio Grande do Sul, Brazil. (4/28)
BACKGROUND: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. METHODS: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. RESULTS: Urine 1-hydroxypyrene glucuronide (1-OHPG) was successfully measured on 199 subjects. The median (interquartile range) of urine 1-OHPG in the 199 participants was 2.09 pmol/mL (0.51, 5.84). Tobacco smoke exposure and mate drinking were statistically significantly associated with higher urine 1-OHPG concentrations in the multivariate linear regression model. CONCLUSION: Tobacco smoke and mate both contribute to high levels of benzo[a]pyrene exposure in the people of southern Brazil. This high PAH exposure may contribute to the high rates of ESCC observed in this population. The increased urine 1-OHPG concentrations associated with mate suggest that contaminants, not just thermal injury, may help explain the increased risk of ESCC previously reported for mate consumption. (+info)Non-alcoholic beverages and risk of bladder cancer in Uruguay. (5/28)
BACKGROUND: Bladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with mate drinking. We conducted an additional case-control study in order to further explore the role of non-alcoholic beverages in bladder carcinogenesis. METHODS: In the time period 1996-2000, 255 incident cases with transitional cell carcinoma of the bladder and 501 patients treated in the same hospitals and in the same time period were frequency matched on age, sex, and residence. Both cases and controls were face-to-face interviewed on occupation, tobacco smoking, alcohol drinking and intake of mate, coffee, tea, and soft drinks. Statistical analysis was carried out by unconditional multiple logistic regression. RESULTS: Ever mate drinking was positively associated with bladder cancer (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.2-3.9) and the risk increased for increasing duration and amount of mate drinking. Both coffee and tea were strongly associated with bladder cancer risk (OR for coffee drinking 1.6, 95% CI 1.2-2.3; OR for tea drinking 2.3, 95% CI 1.5-3.4). These results were confirmed in a separate analysis of never-smokers. CONCLUSION: Our results suggest that drinking of mate, coffee and tea may be risk factors for bladder carcinoma in Uruguay. (+info)Phenolic antioxidants identified by ESI-MS from Yerba mate (Ilex paraguariensis) and green tea (Camelia sinensis) extracts. (6/28)
Aqueous extracts of green yerba mate (Ilex paraguariensis) and green tea (Camellia sinensis) are good sources of phenolic antioxidants, as already described in the literature. The subject of this study were organic extracts from yerba mate, both green and roasted, and from green tea. Their phenolic profiles were characterized by direct infusion electrospray insertion mass spectrometry (ESI-MS) and their free radical scavenging activity was determined by the DPPH assay. Organic extracts containing phenolic antioxidants might be used as natural antioxidants by the food industry, replacing the synthetic phenolic additives used nowadays. Ethanolic and aqueous extracts from green yerba mate, roasted yerba mate and green tea showed excellent DPPH scavenging activity (>89%). The ether extracts from green and roasted yerba mate displayed a weak scavenging activity, different from the behavior observed for the green tea ether extract. The main phenolic compounds identified in green yerba mate water and ethanolic extracts were: caffeic acid, quinic acid, caffeoyl glucose, caffeoylquinic acid, feruloylquinic acid, dicaffeoylquinic acid and rutin. After the roasting process two new compounds were formed: caffeoylshikimic acid and dicaffeoylshikimic acid. The ethanolic extracts from yerba mate, both roasted and green, with lower content of phenolic compounds (3.80 and 2.83 mg/mL) presented high antioxidant activity and even at very low phenolic concentrations, ether extract from GT (0.07 mg/mL) inhibited DPPH over 90%. (+info)Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice. (7/28)
(+info)High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. (8/28)
(+info)"Ilex paraguariensis" is the scientific name for a plant species native to South America, specifically in parts of Argentina, Paraguay, and Brazil. This evergreen tree or shrub belongs to the Aquifoliaceae family and is commonly known as "yerba mate" or "Paraguayan tea."
The leaves of Ilex paraguariensis contain several biologically active compounds, including xanthines (such as caffeine), saponins, polyphenols, and chlorogenic acids. Traditionally, the leaves are dried, chopped, and steeped in hot water to make a popular beverage called "mate," which is consumed for its stimulant effects and potential health benefits. Some studies suggest that yerba mate may have antioxidant, anti-inflammatory, and thermogenic properties; however, more research is needed to confirm these findings and establish the safety and efficacy of Ilex paraguariensis for medicinal purposes.
"Ilex" is a genus name, which refers to a group of plants in the family Aquifoliaceae. It's commonly known as "holly." This group includes over 400 species of evergreen or deciduous shrubs and trees, many of which have glossy, spiny leaves and bright red berries. Some species of Ilex are used in traditional medicine for various purposes, such as treating diarrhea, stimulating digestion, and reducing inflammation. However, it's important to note that the use of herbal remedies should always be discussed with a healthcare provider beforehand, as they can interact with other medications or have unintended side effects.
Chlorogenic acid is a type of polyphenolic compound that is found in various plants, including coffee, tea, and several fruits and vegetables. It is a ester of cinnamic acid and quinic acid. Chlorogenic acids are known to have antioxidant properties and may also play a role in regulating glucose metabolism and inhibiting the growth of certain types of cancer cells. However, more research is needed to fully understand the potential health benefits and risks associated with chlorogenic acid consumption.
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
Glipizide is an oral anti-diabetic medication belonging to the sulfonylurea class. It is used in the management of type 2 diabetes mellitus, by stimulating the release of insulin from the pancreas and reducing glucose production in the liver. Glipizide works by binding to specific receptors on the beta cells of the pancreas, leading to an increase in intracellular calcium levels and ultimately resulting in insulin secretion.
The medical definition of Glipizide is: "A second-generation sulfonylurea used in the treatment of type 2 diabetes mellitus. It acts by binding to specific receptors on the beta cells of the pancreas, leading to an increase in intracellular calcium levels and insulin secretion."
It is important to note that Glipizide should be used with caution in patients with impaired kidney or liver function, as well as those who are at risk for hypoglycemia. Regular monitoring of blood glucose levels is necessary during treatment with Glipizide to ensure safe and effective use.