Rare malignant neoplasm of dendritic LANGERHANS CELLS exhibiting atypical cytology, frequent mitoses, and aggressive clinical behavior. They can be distinguished from other histiocytic and dendritic proliferations by immunohistochemical and ultrastructure studies. Cytologically benign proliferations of Langerhans cells are called LANGERHANS CELL HISTIOCYTOSIS.
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Sarcoma of FOLLICULAR DENDRITIC CELLS most often found in the lymph nodes. This rare neoplasm occurs predominately in adults.
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder.
A sarcoma characterized by the presence of small cells, cells measuring 9-14 micrometers with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. (From Segen, Dictionary of Modern Medicine, 1992)

Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity. (1/6)

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Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases. (2/6)

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Multifocal Langerhans cell sarcoma involving epidermis: a case report and review. (3/6)

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Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression. (4/6)

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Unusual cutaneous Langerhans cell sarcoma without extracutaneous involvement. (5/6)

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Langerhans cell sarcoma in two young children: imaging findings on initial presentation and recurrence. (6/6)

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Langerhans cell sarcoma is a very rare and aggressive type of cancer that affects a specific group of cells called Langerhans cells, which are part of the immune system. These cells are normally found in the skin and mucous membranes, where they help to fight infection. In Langerhans cell sarcoma, these cells become malignant (cancerous) and can multiply and spread to other parts of the body.

Langerhans cell sarcoma is distinct from a more common type of cancer called Langerhans cell histiocytosis, which is not considered a true cancer but rather a disorder of the immune system. The exact cause of Langerhans cell sarcoma is not known, but it is thought to arise from genetic mutations that occur in Langerhans cells.

Symptoms of Langerhans cell sarcoma can vary depending on the location and extent of the cancer. Common symptoms may include skin rashes or lesions, fever, fatigue, weight loss, and swollen lymph nodes. Treatment for Langerhans cell sarcoma typically involves a combination of surgery, chemotherapy, and radiation therapy. However, because this is such a rare and aggressive cancer, treatment options may vary depending on the individual case.

Langerhans cells are specialized dendritic cells that are found in the epithelium, including the skin (where they are named after Paul Langerhans who first described them in 1868) and mucous membranes. They play a crucial role in the immune system as antigen-presenting cells, contributing to the initiation of immune responses.

These cells contain Birbeck granules, unique organelles that are involved in the transportation of antigens from the cell surface to the lysosomes for processing and presentation to T-cells. Langerhans cells also produce cytokines, which help regulate immune responses and attract other immune cells to the site of infection or injury.

It is important to note that although Langerhans cells are a part of the immune system, they can sometimes contribute to the development of certain skin disorders, such as allergic contact dermatitis and some forms of cancer, like Langerhans cell histiocytosis.

Sarcoma, clear cell, is a rare type of cancer that arises from certain types of connective tissue in the body. It is called "clear cell" because the cancer cells have a clear appearance when viewed under a microscope due to the presence of lipids or glycogen within the cytoplasm.

Clear cell sarcoma can occur in various parts of the body, but it most commonly affects the soft tissues of the extremities, such as the legs and arms. It is an aggressive cancer that tends to spread to other parts of the body, including the lungs, lymph nodes, and bones.

Clear cell sarcoma typically occurs in young adults, with a median age at diagnosis of around 30 years old. The exact cause of this type of sarcoma is not known, but it has been linked to genetic mutations involving the EWSR1 gene. Treatment for clear cell sarcoma usually involves surgery to remove the tumor, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells. Despite treatment, the prognosis for patients with clear cell sarcoma is generally poor, with a five-year survival rate of around 50%.

Sarcoma is a type of cancer that develops from certain types of connective tissue (such as muscle, fat, fibrous tissue, blood vessels, or nerves) found throughout the body. It can occur in any part of the body, but it most commonly occurs in the arms, legs, chest, and abdomen.

Sarcomas are classified into two main groups: bone sarcomas and soft tissue sarcomas. Bone sarcomas develop in the bones, while soft tissue sarcomas develop in the soft tissues of the body, such as muscles, tendons, ligaments, fat, blood vessels, and nerves.

Sarcomas can be further classified into many subtypes based on their specific characteristics, such as the type of tissue they originate from, their genetic makeup, and their appearance under a microscope. The different subtypes of sarcoma have varying symptoms, prognoses, and treatment options.

Overall, sarcomas are relatively rare cancers, accounting for less than 1% of all cancer diagnoses in the United States each year. However, they can be aggressive and may require intensive treatment, such as surgery, radiation therapy, and chemotherapy.

Dendritic cell sarcoma, follicular is a very rare type of cancer that affects the dendritic cells, which are a type of immune cell found in the body. Specifically, this type of sarcoma arises from follicular dendritic cells, which are found in the lymph nodes and other lymphoid organs. These cells play an important role in helping the immune system recognize and respond to foreign invaders such as viruses and bacteria.

Dendritic cell sarcoma, follicular typically presents as a mass or enlargement of a lymph node or other lymphoid organ. It can also spread (metastasize) to other parts of the body. The symptoms of this type of cancer may vary depending on the location and extent of the tumor, but they can include swelling of lymph nodes, fever, night sweats, weight loss, and fatigue.

The exact cause of dendritic cell sarcoma, follicular is not known, but it is thought to arise from genetic mutations that occur in the cells over time. Treatment for this type of cancer typically involves a combination of surgery, radiation therapy, and chemotherapy, depending on the stage and location of the tumor.

It's important to note that medical definitions can be complex and technical, and they should not be used as a substitute for professional medical advice. If you have any concerns about your health or symptoms, please consult with a qualified healthcare provider.

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the abnormal proliferation and accumulation of dendritic cells called Langerhans cells in various tissues and organs of the body. These cells are part of the immune system and normally help to fight infection. However, in LCH, an overactive immune response leads to the excessive buildup of these cells, forming granulomas that can damage organs and impair their function.

The exact cause of LCH is not fully understood, but it is thought to involve genetic mutations that lead to uncontrolled cell growth and division. The disorder can affect people of any age, although it is most commonly diagnosed in children under the age of 15.

LCH can affect a single organ or multiple organs, depending on the severity and extent of the disease. Commonly affected sites include the bones, skin, lymph nodes, lungs, liver, spleen, and pituitary gland. Symptoms vary widely depending on the location and severity of the disease, but may include bone pain, rashes, fatigue, fever, weight loss, cough, and difficulty breathing.

Treatment for LCH depends on the extent and severity of the disease. In mild cases, observation and monitoring may be sufficient. More severe cases may require chemotherapy, radiation therapy, or surgery to remove affected tissues. In some cases, immunosuppressive drugs or targeted therapies that target specific genetic mutations may be used.

Overall, LCH is a complex and poorly understood disorder that requires careful evaluation and management by a team of medical specialists. While the prognosis for patients with LCH has improved in recent years, some cases can be life-threatening or lead to long-term complications.

Small cell sarcoma is a very rare and aggressive type of cancer that affects the connective tissues in the body, such as muscles, tendons, bones, cartilage, and fat. It is called "small cell" because the cancer cells are small and appear round or oval in shape, with scant cytoplasm and finely granular chromatin.

Small cell sarcoma typically occurs in adults between the ages of 40 and 70, and it can develop in any part of the body. However, it is most commonly found in the extremities, trunk, and retroperitoneum. The exact cause of small cell sarcoma is not known, but it is thought to be associated with genetic mutations that occur during a person's lifetime.

Small cell sarcoma can be difficult to diagnose because it often does not cause any symptoms until it has advanced to an aggressive stage. When symptoms do occur, they may include pain, swelling, or a lump in the affected area. Diagnosis typically involves a biopsy of the tumor tissue, followed by imaging tests such as CT scans, MRI scans, or PET scans to determine the extent of the cancer.

Treatment for small cell sarcoma usually involves surgery to remove the tumor, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells. However, because small cell sarcoma is so rare and aggressive, treatment options may be limited, and the prognosis is often poor. Clinical trials of new treatments are also an option for some patients.

Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell ... Langerhans cell sarcoma (LCS) is a rare form of malignant histiocytosis. It should not be confused with Langerhans cell ... Langerhans cell sarcoma can occur de novo, or can occur as a malignant transformation of Langerhans cell histiocytosis. The ... Langerhans Cell Sarcoma (LCS) is a cancerous disease caused by the uncontrolled overproliferation of Langerhans cells. Because ...
... is seen in osteosarcoma, Ewing sarcoma and Langerhans cell histiocytosis. In radiological images ...
Some types of cancers can cause it such as rhabdomyosarcoma, extrosseal Ewing sarcoma, Langerhans cell histiocytosis, ... cancer due to malignancy of mesenchymal cells that have failed to fully differentiate into muscle cells Langerhans cell ... Condition due to excess build-up of Langerhans cells. Lupus: autoimmune disease Diagnosis of the medical condition is based on ... This condition results in structural change of red blood cells (RBCs), shearing of RBCs, and anemia. Hemolytic disease of the ...
Amongst leukocytes, E-cadherin expression is unique to Langerhans cells. Langerhans cells utilize E-cadherin to localize in the ... Histiocytic sarcoma Localized histiocytic sarcoma Diffuse histiocytic sarcoma Histiocytoma is a common, benign, cutaneous ... and poorly differentiated mast cell tumors. Cutaneous histiocytoma = Langerhans cells: CD1+, CD11c+, MHCII+, CD86+, E-cad+, ... derived from specialised epidermic dendritic cells, the Langerhans cells) 2. Reactive histiocytosis (immunohistochemical ...
Langerhans cell histiocytosis (LCH) Lymphangioleiomyomatosis (LAM) Lymphocytic interstitial pneumonia (LIP) Birt-Hogg-Dubé ... This form of presentation has been described in metastatic sarcomas. A focal lung pneumatosis that is an incidental imaging ...
9.2.2 Rosai-Dorfman disease 9.2.3 Juvenile xanthogranuloma 9.2.4 Langerhans cell histiocytosis 9.2.5 Histiocytic sarcoma 10.1 ... granular cell tumor of the sellar region, and spindle cell oncocytoma 11.4 Pituitary adenoma/PitNET 11.5 Pituitary blastoma ... 9.1.2.4 T-cell and NK/T-cell lymphomas 9.2 Histiocytic tumors 9.2.1 Erdheim-Chester disease ... FET-CREB fusion-positive 7.1.4.2 CIC-rearranged sarcoma 7.1.4.3 Primary intracranial sarcoma, DICER1-mutant 7.1.4.4 Ewing ...
... sarcoma Malignant diseases of macrophages Histiocytic lymphoma A histiocytoma originates from epidermal Langerhans cells of ... Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and ... Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M (2006). "Langerhans cells arise ... A similar disease in humans, Hashimoto-Pritzker disease, is also a Langerhans cell histiocytosis. Dog breeds that may be more ...
Langerhans cell histiocytosis, Langerhans cell sarcoma, lymphoma, sarcoidosis, IgG4-related disease, and tuberculosis. The ... non-Langerhans cell histiocytoses". Rosai-Dorfman disease itself was classified into "Familial", "Classical (nodal)", " ... Microscopic examination of stained specimens will show histiocytes with lymphocytes and possibly other types of cells trapped ... "Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages". Blood. 127 (22): 2672-2681. ...
Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and ... Affolter V, Moore P (2002). "Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs". Vet Pathol. 39 ( ... Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M (2006). "Langerhans cells arise ... They include the following: Reactive diseases of Langerhans cells (most important feature in immune histochemistry is ...
Cell Cycle. 2013, 12(4):547-52. Chan JM, Bilodeau E, Celin S, Nikiforov Y, Johnson JT. Ewing sarcoma of the thyroid: Report of ... Yousem SA, Dacic S, Nikiforov YE, Nikiforova M. Pulmonary Langerhans Cell Histiocytosis: Profiling of Multifocal Tumors Using ... Cell. 2014 Oct 23;159(3):676-90. Nikiforov YE, Carty SE, Chiosea SI, Coyne C, Duvvuri U, Ferris RL, Gooding WE, Hodak SP, ... Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G0-phase human cells ...
Schwann cells, and melanocytes), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells ... paraganglioma stromal cells, histiocytoma, and clear-cell sarcomas. Further, S100 proteins are markers for inflammatory ... "Differentiation of Langerhans cells from interdigitating cells using CD1a and S-100 protein antibodies". Biotechnic & ... Wilson, AJ; Maddox, PH; Jenkins, D (January 1991). "CD1a and S100 antigen expression in skin Langerhans cells in patients with ...
... monostotic Langerhans cell histiocytosis, polystotic Langerhans cell histiocytosis, disseminated Langerhans cell sarcoma ... dendritic cell tumour Interdigitating dendritic cell sarcoma Follicular dendritic cell sarcoma Fibroblastic reticular cell ... associated lymphoproliferative disorders Histiocytic and dendritic cell neoplasms Histiocytic sarcoma Langerhans cell ... NOS Germinal centre B-cell subtype Activated B-cell subtype T-cell/histiocyte-rich large B-cell lymphoma Primary DLBCL of the ...
van den Berg LM, Geijtenbeek TB (2012). "Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 ... Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the ... a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells". Cell. 100 (5): 587-97. doi:10.1016/ ... On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and ...
... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... islet cell - islet cell cancer - islet of Langerhans cell - isoflavone - isointense - isolated hepatic perfusion - isolated ... cell - cell differentiation - cell motility - cell proliferation - cell respiration - cell adhesion - cellular adoptive ... specific immune cell - SPECT - SPF - spiculated mass - spindle cell cancer - spindle cell sarcoma - spiral CT scan - ...
... large-cell MeSH C15.604.667.400.390.550.465 - lymphoma, large-cell, ki-1 MeSH C15.604.667.400.400 - histiocytosis, langerhans- ... mast-cell sarcoma MeSH C15.604.744.293 - hypersplenism MeSH C15.604.744.428 - myeloid metaplasia MeSH C15.604.744.617 - splenic ... cell MeSH C15.604.667.400.400.360 - eosinophilic granuloma MeSH C15.604.667.400.410 - histiocytosis, non-langerhans-cell MeSH ... mantle-cell MeSH C15.604.515.569.480.475 - lymphoma, large-cell MeSH C15.604.515.569.480.475.300 - lymphoma, large-cell, ...
... lesions Non-small cell lung cancer Thyroid cancer Kidney cancer Multiple myeloma Melanoma Non-Hodgkin lymphoma Langerhans cell ... Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor is ... Tumor cells may have paraneoplastic effects, such as via the secretion of Prostaglandin E, TGF-alpha, TGF-beta, TNF, and ... The triggers which eventually awaken metastatic tumor cells are an active field of study as they could elucidate mechanisms of ...
Due to the elevated levels of blood glucose in an individual, the β-cells (islets of Langerhans) in the pancreas must release ... polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells". Oncology Reports. 9 (3): ... The more receptors a cell has that are tuned to the message, the more the cell will respond to it. Receptors are created, or ... This process is illustrated by the insulin receptor sites on target cells, e.g. liver cells, in a person with type 2 diabetes. ...
X M9755/3 Histiocytic sarcoma True histiocytic lymphoma M9756/3 Langerhans cell sarcoma M9757/3 Dendritic cell sarcoma, NOS ... Pleomorphic cell sarcoma M8803/3 Small cell sarcoma Round cell sarcoma M8804/3 Epithelioid sarcoma Epithelioid cell sarcoma ... NOS M9752/1 Langerhans cell histiocytosis, unifocal Langerhans cell granulomatosis, unifocal Langerhans cell histiocytosis, ... multifocal Langerhans cell histiocytosis, poly-ostotic M9754/3 Langerhans cell histiocytosis, disseminated Langerhans cell ...
Langerhans cell histiocytosis) lower (e.g., cryptogenic fibrosing alveolitis, connective tissue disease, asbestosis, drug ... sarcoma/infection/infarction/vascular Doubling time of six to 18 months: benign tumor/malignant granuloma Doubling time of more ... cystic bronchiectasis Langerhans cell histiocytosis lymphangioleiomyomatosis Ground glass extrinsic allergic alveolitis ... Langerhans cell histiocytosis, lymphangioleiomyomatosis, cystic fibrosis, allergic bronchopulmonary aspergillosis) decreased (e ...
The epidermis contains four cell types: keratinocytes, melanocytes, Langerhans cells, and Merkel cells. Of these, keratinocytes ... Diffuse large B-cell lymphoma (primary cutaneous large B-cell lymphoma) Granulocytic sarcoma (chloroma, myeloid sarcoma) ... pale cell acanthoma) Clear cell squamous cell carcinoma (clear cell carcinoma of the skin) Chronic scar keratosis (chronic ... Solitary trichoepithelioma Spindle cell squamous cell carcinoma (spindle cell carcinoma) Spiradenoma Squamous cell carcinoma ...
"Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans". Gene. 165 (2): 329- ... "Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus". Journal of Virology ... plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN ... May 2020). "B Cell Tetherin: A Flow Cytometric Cell-Specific Assay for Response to Type I Interferon Predicts Clinical Features ...
2020), who consider Langerhans cell histiocytosis to be the most likely diagnosis, making it the first case of LCH recognized ... who interpret their findings as evidence of these sauropods being affected by pathologies similar to Ewing's sarcoma and avian ... Bruce M. Rothschild; Darren Tanke; Frank Rühli; Ariel Pokhojaev; Hila May (2020). "Suggested case of Langerhans Cell ... Cell Research. 30 (8): 693-701. doi:10.1038/s41422-020-0349-y. PMC 7395088. PMID 32581344. Gerald Mayr; Thomas Lechner; ...
CSF1R signaling is necessary for differentiation of microglia and Langerhans cells which are derived from yolk sac progenitor ... sarcoma, and leukemias. In 2019, Pexidartinib was FDA-approved for treatment of diffuse-type tenosynovial giant cell tumors, a ... CSF1R signaling has been found to play important roles in non-myeloid cells such as neural progenitor cells, multipotent cells ... Hematopoietic stem cells express CSF1R at low levels, but CSF1R is highly expressed in more differentiated myeloid cell types ...
Paul Langerhans (1847-1888), German pathologist, physiologist and biologist. William Boog Leishman (1865-1926), English ... Max Askanazy (1865-1940), German pathologist (see Askanazy cell). E. Ask-Upmark, 20th-century Swedish pathologist (see Ask- ... eponymist of Ewing's sarcoma, one of the founders of AACR. Robert (Robin) Sanno Fåhræus (1888-1968), Swedish pathologist (see ... see Sarcoma). William Henry Welch (1850-1934), American physician, pathologist, bacteriologist, medical school administrator, ...
He detected HHV8 virus in classical Kaposi's sarcoma and Merkel cell polyomavirus in Merkel-cell carcinoma. European ... BRAFV600E mutation in cutaneous lesions of patients with adult Langerhans cell histiocytosis, JOURNAL OF THE EUROPEAN ACADEMY ... Committee supervising the research and terapeutic use of embrionyc and tissue stem cells" Medical Sciences Section of the ... chemokines and human beta-defensin-2 in vaginal epithelial cells, MICROBES AND INFECTION 7: (9-10) pp. 1117-1127, 2005. Nagy I ...
1989). "T-cell response to purified protein derivative after removal of Langerhans' cells from epidermal cell suspensions ... Bénichou S, Benmerah A (2003). "The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the ... Antigen-presenting cells (macrophages, B-cells and dendritic cells) are the cells in which DR are typically found. Increased ... These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation. The primary function of HLA-DR is ...
1989). "T-cell response to purified protein derivative after removal of Langerhans' cells from epidermal cell suspensions ... The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). ... Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha ... Cell. Biol. 12 (12): 5610-9. doi:10.1128/MCB.12.12.5610. PMC 360500. PMID 1448091. Schaiff WT, Hruska KA, McCourt DW, et al. ( ...
... and malignant cells of bone and soft tissue sarcomas. FAP is thought to be involved in the control of fibroblast growth or ... of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets". ... and in adults in pancreatic alpha cells in multipotent bone marrow stromal cells (BM-MSC) and uterine stroma. FAP expression is ... Fassnacht M, Lee J, Milazzo C, Boczkowski D, Su Z, Nair S, Gilboa E (August 2005). "Induction of CD4(+) and CD8(+) T-cell ...
... subsequent research revealed that other cells (such as keratinocytes, fibroblasts and epithelial Langerhans cells) could also ... The SV40 promoter was conventionally used until research showed that vectors driven by the Rous Sarcoma Virus (RSV) promoter ... The type of T-cell help raised is determined by the differentiated state of antigen presenting cells. Dendritic cells can ... which include dendritic cells, macrophages and specialised B-cells called professional antigen presenting cells (APC). After ...
... of Langerhans cell histiocytosis patients. The V600E mutation is a likely driver mutation in 100% of cases of hairy cell ... The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is ... The B-Raf protein is involved in sending signals inside cells which are involved in directing cell growth. In 2002, it was ... "Recent advances in the understanding of Langerhans cell histiocytosis". British Journal of Haematology. 156 (2): 163-172. doi: ...
Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell ... Langerhans cell sarcoma (LCS) is a rare form of malignant histiocytosis. It should not be confused with Langerhans cell ... Langerhans cell sarcoma can occur de novo, or can occur as a malignant transformation of Langerhans cell histiocytosis. The ... Langerhans Cell Sarcoma (LCS) is a cancerous disease caused by the uncontrolled overproliferation of Langerhans cells. Because ...
Langerhans cell histiocytosis.. *Malignant melanoma.. *Sarcoma.. *Verrucous carcinoma.. References. *Bornstein J, Bogliatto F, ... Piura B, Masotina A, Murdoch J, et al.: Recurrent squamous cell carcinoma of the vulva: a study of 73 cases. Gynecol Oncol 48 ( ... Binder SW, Huang I, Fu YS, et al.: Risk factors for the development of lymph node metastasis in vulvar squamous cell carcinoma ... Hopkins MP, Reid GC, Johnston CM, et al.: A comparison of staging systems for squamous cell carcinoma of the vulva. Gynecol ...
langerhans cell sarcoma Fri Jul 08, 2011 1:59 pm. RoseC. 1. Anal cancer Wed Jul 20, 2011 8:55 pm. ... Hepatic Undifferentiated Embryonal Sarcoma Sun Aug 16, 2009 4:20 pm. ruelostogi. 2. histiocytic sarcoma Fri Nov 06, 2009 11:43 ... Chromophobic renal cell carcinoma Fri May 27, 2011 5:49 pm. robertdr60. 6. Squamous Cell Rectal Cancer Wilkes-Barre/Scranton PA ... acinic cell carcinoma (acinar cell) Tue Jan 11, 2005 11:19 am. ... Large Cell Neuroendocrine Carcinoma of the Cervix Sun Sep 26, ...
Langerhans cell histiocytosis. ND. Histiocytic sarcoma. ND. Germ cell tumors. Mature teratoma ... Pituicytoma, granular cell tumor of the sellar region, and spindle cell oncocytoma ... Pituicytoma, granular cell tumor of the sellar region, and spindle cell oncocytoma ... which reflects the degree of abnormal behavior displayed by the tumor cells themselves. Because neoplasms in the CNS have ...
Kaposi Sarcoma Adult Langerhans Cell Histiocytosis Childhood Laryngeal Cancer Treatment (Adult) Adult ... Genetics of Kidney Cancer (Renal Cell Cancer) (PDQ®)-Health Professional Version Genetics of Prostate Cancer (PDQ®)-Health ...
Langerhans cell sarcoma: a case report and review of the literature. Liu DT, Friesenbichler J, Holzer LA, Liegl-Atzwanger B, ... Early cerebrospinal fluid infiltration in TP53-mutated blastic plasmacytoid dendritic cell neoplasm. Michaelis S, Pichler A, ... Bone marrow aspirations in Ewing sarcomas: Are they still necessary? A single-center retrospective analysis and review of the ...
Kaposis sarcoma in renal transplant recipients: pathogenetic relation between the reduced density of Langerhans cells and ... Malignancies, including squamous cell carcinoma, keratoacanthoma, basal cell carcinoma, Kaposi sarcoma, melanoma ... Although Kaposi sarcoma is the most commonly reported sarcoma in renal transplant recipient, other cutaneous sarcomas have been ... Azathioprine and its metabolites are mutagenic and toxic to Langerhans cells, but CyA is more immunosuppressive. ...
... dendritic cell sarcoma; JXG, juvenile xanthogranuloma; G, genital; GCT, granular cell tumor; L, lung; LCH, Langerhans cell ... First, our BRAF mutated Langerhans cell sarcoma patient had died; therefore, given the rarity and aggressiveness of this ... BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis. Blood. 2012; 120(12): ... of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF-V600E-mutant whereas all non-Langerhans cell ...
Langerhans cell histiocytosis. ND. Histiocytic sarcoma. ND. Germ cell tumors. Mature teratoma ... Pituicytoma, granular cell tumor of the sellar region, and spindle cell oncocytoma ... Pituicytoma, granular cell tumor of the sellar region, and spindle cell oncocytoma ... which reflects the degree of abnormal behavior displayed by the tumor cells themselves. Because neoplasms in the CNS have ...
Kaposi sarcoma, sarcoidosis, keloid scars, histiocytosis of Langerhans cells, melanoma, dermatofibrosarcoma, lymphoma, squamous ... Pagliari C, Kanashiro-Galo L, Silva AA, Barboza TC, Criado PR, Duarte MI, et al. Plasmacytoid dendritic cells in cutaneous ... Nodular lesions have cellular components that result in more active immune response cells and less active cells in infiltrative ... Thus, a diagnosis is made by skin biopsy showing a large number of yeasts of uniform size and thick cell walls that form chains ...
Discover a rare case of adult Langerhans cell histiocytosis in the spine causing spinal cord compression. Learn about the ... and evoking a differential diagnosis with Ewings sarcoma, a tuberculoma, or osteomyelitis [22] . Ver- tebral lesions imaging ... Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young ... Langerhans cell histiocytosis (LCH) is an orphan disease. In 1868, Langerhans discovered the epidermal dendritic cells that now ...
Complete remission of disseminated Langerhans cell sarcoma after stem cell transplantation. Schlintl, Verena; Schlick, ... Langerhans cell sarcoma represents an orphan malignant disease deriving from histiocytic cells. Clinical course is extremely ... Herein, we describe the case of a young patient with fulminant development of metastatic Langerhans cell sarcoma, who achieved ... Application of genetically engineered T cells (i.e. chimeric antigen receptor T cells, CAR-T cells) has proven to be highly ...
Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. Am J Dermatopathol. 2013 Apr; ... High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines. Epigenetics. 2014 Feb; 9(2):297 ... SFRP1 promoter methylation and expression in human trabecular meshwork cells. Exp Eye Res. 2012 Apr; 97(1):130-6. ...
Langerhans cell histiocytosis, endodermal sinus tumors (ESTs), and myeloid sarcoma. Analysis was performed on tissue sections ... Specimens included those from rhabdomyosarcomas, Wilms tumors, Ewing sarcoma/primitive neuroectodermal tumors, peripheral ... is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is di erentially ... Langerhans cell histiocytosis, endodermal sinus tumors (ESTs), and myeloid sarcoma. Analysis was performed on tissue sections ...
Initiative is a rare-cancer global outreach initiative that provides free genomic profiling for patients with Langerhans Cell ... and Histiocytic Sarcoma (HS). Genomic profiling with world class, next-generation sequencing technology developed at Memorial ...
Histiocytosis X (Langerhans Cell Histiocytosis) + Letterer-Siwe Histiocytosis + Hand-Schüller-Christian Histiocytosis ... Histiocytic Sarcoma + Metastatic Infiltration of the Bone Marrow + Posttheraupetic a Posttransplant Hematopoietic Changes + ...
Langerhans cell sarcoma involving skin and showing epidermotropism: a comprehensive review (*Mentor of a Dermatopathology ... T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma. J ... Concomitant Cutaneous Langerhans Cell Hystiocytosis and Leukemia Cutis. Am J Dermatopathol. e-Pub 2016. PMID: 27759701. ... Multiple Skin Lesions Showing Pleomorphic Epithlioid Cells in a Patient with a History of Metastatic Melanoma and Langerhans ...
Langerhans Cell Sarcoma Whats New Last Posted: Apr 21, 2014 * Frequent detection of BRAF(V600E) mutations in histiocytic and ... dendritic cell neoplasms. Go Heounjeong, et al. Histopathology 2014 8 (2) 261-72 ...
Langerhans cell sarcoma (morphologic abnormality). Code System Preferred Concept Name. Langerhans cell sarcoma (morphologic ...
Langerhans cell histiocytosis; Langerhans cell neoplasm; Langerhans cell sarcoma; Merkel cell polyomavirus; RAS/MAPK signaling ... of immune system cells called Langerhans cells in Langerhans cell histiocytosis 348... Langerhans cell histiocytosis in Japan ... Langerhans cells send out special agents - immune cells such as T cells and B cells - immediately after sensing any kind of ... precursor Langerhans cells, or Langerhans cells are one of the reservoir cells for MCPyV. Histiocytic disorders of children and ...
Langerhans cell sarcoma DOID:7146 * cutaneous T cell lymphoma DOID:0060061 * fungal esophagitis ...
... or T-cell lymphomas or leukemias Microscopic Pathology Partial or complete replacement of… ... Interdigitating Reticulum Cell Sarcoma Wesley O. Greaves, MD L. Jeffrey Medeiros, MD Cyril Fisher, MD, DSc, FRCPath Key Facts ... Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with ... Antigen-presenting cell involved in T-cell immunity. *. Derived from CD34(+) lymphoid/myeloid progenitor cell in bone marrow ...
T-cell lymphoma* plasmacytoma* Langerhans cell histiocytosis* myeloid sarcoma* follicular dendritic cell sarcoma* melanoma* ... granular cell tumor* keratoacanthoma* salivary gland tumors* see salivary gland section* soft tissue* Kaposi sarcoma* ... congenital granular cell epulis* fibroma* lobular capillary hemangioma* peripheral ossifying fibroma* peripheral giant cell ... squamous cell hyperplasia* dysplasia* mild* moderate* severe* carcinoma in situ* benign epithelial* papillomas* squamous ...
Deryn was just days from death due to the extremely rare langerhans cell sarcoma and his mother was alarmed by his levels of ...
RESULTS: The specific diagnoses of transdifferentiated HDCN tumors were histiocytic sarcoma (16); Langerhans cell histiocytosis ... Severe lymphocytosis was identified on complete blood cell count (69,600 cells /uL; reference range: 1,500-4,000 cells/uL), ... These cells were also detected in bone marrow cytology. Immunhistochemical examination was performed and the cells reacted ... Blood has never been thicker: Cell-free DNA fragmentomics in the liquid biopsy toolbox of B-cell lymphomas. ...
Mesodermal cell/mesoblast sarcoma. Pancreas - Islet of Langerhans. None (spontaneous). NZW/LacJ inbred observed. Peritoneal ... Mesodermal cell/mesoblast sarcoma - stromal. Uterus - Endometrium - Stroma. None (spontaneous). NZW/LacJ inbred 0. Summary ... Mesodermal cell/mesoblast sarcoma. Seminal vesicle. None (spontaneous). NZW/LacJ inbred 0. Summary ... Mesodermal cell/mesoblast sarcoma. Peritoneal cavity. None (spontaneous). NZW/LacJ inbred 0. 0. Summary ...
Langerhans cell histiocytosis mimicking molluscum contagiosum. J Am Acad Dermatol. 2012 Sep; 67(3):e117-8. ... Kaposi sarcoma in association with molluscum contagiosum: an uncommon diagnosis in a single biopsy and potential diagnostic ...
Refractory Ewing Sarcoma, Refractory Hepatoblastoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Germ Cell ... Refractory Ewing Sarcoma, Refractory Hepatoblastoma, Refractory Langerhans Cell Histiocytosis, Refractory Malignant Germ Cell ... Enteropathy-Associated T-Cell Lymphoma, Follicular T-Cell Lymphoma, Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Monomorphic ... Conditions: Recurrent Ependymoma, Recurrent Ewing Sarcoma, Recurrent Hepatoblastoma, Recurrent Langerhans Cell Histiocytosis, ...
Langerhans cell histocytosis (LCH), leukaemia and NB. The longest delay was 101.0 days in patients with HD. Median physician ... Ewing sarcoma and osteosarcoma), germ cell tumours (GCTs), brain tumours, and histiocyte disorders. ... Widhe B, Widhe T. Initial symptoms and clinical features in osteosarcoma and Ewing sarcoma. J Bone Joint Surg Am. 2000 May;82(5 ... Some slow-growing tumours (ganglioglioma or localized Ewing sarcoma) are more common in older children in comparison to some ...
  • Langerhans cell sarcoma (LCS) is a rare form of malignant histiocytosis. (wikipedia.org)
  • It should not be confused with Langerhans cell histiocytosis, which is cytologically benign. (wikipedia.org)
  • Dendritic cell neoplasms are classified by the World Health Organization as follows: Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell sarcoma/tumor Dendritic cell sarcoma The exact incidence of LCS is unknown due to the rarity of the condition. (wikipedia.org)
  • The related condition, Langerhans Cell Histiocytosis (LCH) is estimated to have an incidence of around 5 cases per 1 million people per year. (wikipedia.org)
  • Langerhans cell sarcoma can occur de novo, or can occur as a malignant transformation of Langerhans cell histiocytosis. (wikipedia.org)
  • Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
  • We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
  • Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)
  • A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
  • The Memorial Sloan Kettering Make-an-IMPACT Initiative is a rare-cancer global outreach initiative that provides free genomic profiling for patients with Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Rosai-Dorfman Disease (RDD), Juvenile Xanthogranuloma (JXG), and Histiocytic Sarcoma (HS). (histio.org)
  • Sakata N, Toguchi N, Kimura M, Nakayama M, Kawa K, Takemura T. Development of Langerhans cell histiocytosis associated with chronic active Epstein-Barr virus infection. (mayabouchenaki.com)
  • Murakami I, Gogusev J, Fournet JC, Glorion C, Jaubert F. Detection of molecular cytogenetic aberrations in langerhans cell histiocytosis of bone. (mayabouchenaki.com)
  • Erdem AP, Kasimoglu Y, Sepet E, Gencay K, Sahin S, Dervisoglu S. Oral manifestations may be the first sign of Langerhans cell histiocytosis. (mayabouchenaki.com)
  • Langerhans cell histiocytosis mimicking molluscum contagiosum. (harvard.edu)
  • Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
  • Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
  • OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
  • Pathology of the tissue biopsy demonstrated proliferation of macrophages or dendritic cells, and positive staining with CD1a confirmed a diagnosis of Langerhans' cell histiocytosis (See Figure 2) . (reviewofophthalmology.com)
  • Langerhans' cell histiocytosis (LCH), previously known as histiocytosis X, describes a rare spectrum of conditions with abnormal proliferation of histiocytes, occuring in various locations throughout the body. (reviewofophthalmology.com)
  • National death data collected by the US Vital Statistics Reporting System and aggregated using wonder.cdc.gov were analyzed for underlying cause of death due to malignant histiocytosis (MH), Langerhans cell histiocytosis (LCH) and Letterer-Siwe disease (LS, a form of LCH) for 3 periods: 1979-1988, 1989-1998, and 1999-2006. (johnshopkins.edu)
  • Symptoms of Langerhans' Cell Histiocytosis vary depending on the part of the body affected and the severity of the disease. (homeremedylifestyle.com)
  • Langerhans' cell histiocytosis can cause symptoms in the skin, bones, lungs, and other parts of the body. (homeremedylifestyle.com)
  • The symptoms of Langerhans' cell histiocytosis include pain, swelling, and brown or red skin sores. (homeremedylifestyle.com)
  • Langerhans' cell histiocytosis is a rare disease . (homeremedylifestyle.com)
  • Children with Langerhans' cell histiocytosis have a high risk of developing cancer. (homeremedylifestyle.com)
  • Single-system Langerhans' cell histiocytosis responds well to chemotherapy. (homeremedylifestyle.com)
  • Multisystem Langerhans' cell histiocytosis, however, is fatal in severe cases. (homeremedylifestyle.com)
  • The treatment for Langerhans' cell histiocytosis will depend on the organs affected. (homeremedylifestyle.com)
  • Having a diagnosis of Langerhans' Cell Histiocytosis can be a scary time for a family. (homeremedylifestyle.com)
  • A diagnosis of Langerhans' Cell Histiocytosis is dependent on a number of factors. (homeremedylifestyle.com)
  • A diagnosis of Langerhans' cell histiocytosis should be made only after the patient has undergone a biopsy . (homeremedylifestyle.com)
  • Another way to diagnose Langerhans cell histiocytosis is by examining the lymph nodes. (homeremedylifestyle.com)
  • The best way to treat Langerhans' cell histiocytosis is to have the disease treated by experts who understand the disease. (homeremedylifestyle.com)
  • Approximately one out of every 200,000 children develops Langerhans cell histiocytosis every year. (homeremedylifestyle.com)
  • We pursued target-capture next generation sequencing (NGS) on tissue specimen of patients with various histiocytic neoplasms- Erdheim-Chester disease (ECD), Langerhans cell histiocytosis (LCH), Rosai-Dorfman disease (RDD), histiocytic sarcoma (HS), and Langerhans cell sarcoma (LCS). (tempus.com)
  • An idiopathic variation of Langerhans cell histiocytosis , commonly seen as a non-neoplastic osteolytic lesion of bone. (logicalimages.com)
  • cell histiocytosis and giant cell tumor. (neobiotechnologies.com)
  • Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
  • Pulmonary Langerhans Cell Histiocytosis Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
  • Langerhans cell histiocytosis (LCH) is a dendritic cell (antigen-presenting cell) disorder. (msdmanuals.com)
  • Symptoms and signs of Langerhans cell histiocytosis vary considerably depending on which organs are infiltrated. (msdmanuals.com)
  • SummaryDiffuse large B‑cell lymphoma (DLBCL) comprises 30-40% of non-Hodgkin's lymphoma. (deepdyve.com)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • Keyword: Non-Hodgkin's Lymphoma, high-grade B-cell lymphoma, plexopathy. (bvsalud.org)
  • INTRODUCTION: Integration of molecular characterization of lymphomas in clinical diagnostics may improve subclassification and risk-stratification, and we implemented a next generation sequencing (NGS) analysis as part of routine diagnostic work-up of all mature B-cell non-Hodgkin's lymphoma (B-NHL). (bvsalud.org)
  • Richter's Transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma or Hodgkin lymphoma (both are B-cell origin) are well described in literature. (najms.com)
  • Michelis FV, Kourti G, Skertsou M. Richter transformation of chronic lymphocytic leukemia into composite diffuse large B-cell and Hodgkin lymphoma. (najms.com)
  • Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M. Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: Evidence for transdifferentiation of the follicular lymphoma clone. (najms.com)
  • Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: Evidence for transdifferentiation of the lymphoma clone. (najms.com)
  • Shao H, Xi L, Raffeld M, Feldman AL, Ketterling RP, Knudson R. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. (najms.com)
  • Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A. Histiocytic sarcoma arising in indolent small b-cell lymphoma: Report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution. (najms.com)
  • Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: A case report and review of literature. (najms.com)
  • IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. (najms.com)
  • In lymphoma, the cells in the lymphatic system grow abnormally, dividing too rapidly and growing without any order or control (Longe 2005). (newworldencyclopedia.org)
  • DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. (newworldencyclopedia.org)
  • green indicates genes that are overexpressed in normal cells compared to lymphoma cells and red indicates genes that are overexpressed in lymphoma cells compared to normal cells. (newworldencyclopedia.org)
  • The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
  • Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
  • 38= Cutaneous T-cell lymphoma, NOS (C44. (cancercentrum.se)
  • Chemotherapy regimens that have documented responses include lymphoma protocols with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) and rituximab with CHOP (R-CHOP) as well as sarcoma protocols of doxorubicin and ifosfamide or gemcitabine and a taxane [ 6 ]. (biomedcentral.com)
  • Histiocytic neoplasms are rare disorders of the monocyte-macrophage-dendritic cell lineage that pose significant management challenges to the clinicians. (tempus.com)
  • 1 ] and was since classified in the 2008 World Health Organization classification of haematolymphoid neoplasms with tumours of histiocytes and dendritic cells, alongside other dendritic cell tumours including Langerhans cell tumours, interdigitating dendritic cell sarcoma and other rare tumours. (biomedcentral.com)
  • Cells from these tumor samples will display features characteristic of Langerhans cells, but with additional signs of malignancy, such as increased mitoses, cellular atypia, and pleomorphic nuclei. (wikipedia.org)
  • As such, CNS tumor classification heavily relies on accurate grading , which reflects the degree of abnormal behavior displayed by the tumor cells themselves. (medscape.com)
  • Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
  • Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. (tubitak.gov.tr)
  • Anti-tumor activity of the HSP90 inhibitor SNX-2112 in pediatric cancer cell lines. (ucdavis.edu)
  • Biopsy of the lesion is necessary to confirm the diagnosis as other orbital lesions in children, such as neuroblastoma, Ewing sarcoma and Wilms tumor, and other bony tumors may also present similarly on clinical exam and radiographic imaging. (reviewofophthalmology.com)
  • This classification attempts to classify lymphomas by cell type (i.e. the normal cell type that most closely resembles the tumor). (newworldencyclopedia.org)
  • B-cell heavy chain rearrangement study on blood sample (pure CLL) and liver metastatic NEC (pure NEC, no contamination from CLL) revealed that these two tumors shared similar monoclonal peaks. (najms.com)
  • Dendritic cell tumors associated with low-grade b-cell malignancies. (najms.com)
  • They play a major role in defending the host from both tumors and virally infected cells. (newworldencyclopedia.org)
  • These tumors demonstrate papillary structures with a delicate fibrovascular core lined by columnar or cuboidal epithelial cells with vesicular basal nuclei. (radiopaedia.org)
  • Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)
  • Primitive Spindle Cell Neoplasm of Ileum with Extensive Heterotopic Cartilage, Presenting as Acute Abdomen in a 6-Day-Old Neonate. (ucdavis.edu)
  • Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm of mesenchymal stem cell origin whose clinical course displays much variability. (biomedcentral.com)
  • Antigen-presenting cells are also termed Dendritic cells, of which Langerhans cells are a subtype. (wikipedia.org)
  • Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)
  • Bone marrow aspirations in Ewing sarcomas: Are they still necessary? (nih.gov)
  • Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients. (ucdavis.edu)
  • It has previously been mistaken with metastatic melanoma and metastatic large-cell carcinoma. (wikipedia.org)
  • This condition is characterized by a large, noncancerous patch of abnormally dark skin that is present from birth and an increased risk of a type of skin cell cancer called melanoma (described below). (medlineplus.gov)
  • Additional gene mutations in cells within the nevus after birth can lead to melanoma in people with giant congenital melanocytic nevus. (medlineplus.gov)
  • LCH is characterized by the proliferation of CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells (LCH cells) generating inflammatory granuloma. (mayabouchenaki.com)
  • Microscopic review of the tissue specimen revealed proliferation of histiocytes (left) with positive CD1a staining, a marker for Langerhans' cells (right). (reviewofophthalmology.com)
  • Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
  • This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation. (medlineplus.gov)
  • The unregulated cell proliferation of early melanocytes leads to a large patch of darkly pigmented skin characteristic of giant congenital melanocytic nevus. (medlineplus.gov)
  • This rare condition is characterized by the abnormal production and accumulation of immune system cells called histiocytes in many of the body's tissues. (medlineplus.gov)
  • In immunohistochemical study, these eosinophilic cells expressed CD1a and S100 protein. (scirp.org)
  • Positive immunohistological staining with neuronal markers S100 and CD1a are specific for Langerhans' cells and help to confirm the diagnosis. (reviewofophthalmology.com)
  • He is the In Charge of the Paediatric Stem Cell Transplantation program which has to its credit transplanting the smallest baby in the world (transplanted for Neuroblastoma at the age of 4 months) and the youngest thalassemia transplant in India at 9 months. (kokilabenhospital.com)
  • Sagransky MJ, Deng AC, Magro CM. Primary cutaneous langerhans cell sarcoma: a report of four cases and review of the literature. (umassmed.edu)
  • Kaposi sarcoma in association with molluscum contagiosum: an uncommon diagnosis in a single biopsy and potential diagnostic pitfall. (harvard.edu)
  • In cultures, a subpopulation of Kaposi sarcoma cells express CD14. (neobiotechnologies.com)
  • In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
  • Because Langerhans cells are most commonly found in the mucosa and the skin, LCS is thought to usually begin here with further spread to other areas of the body via the lymphatic system. (wikipedia.org)
  • Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. (najms.com)
  • Ironically, the lymphatic system is fundamentally important for combating cancer cells-as well as foreign bodies, such as viruses and bacteria , and combating heart disease and arthritis as well. (newworldencyclopedia.org)
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
  • We treat all cancers occurring in children and young people (including brain tumours, solid tumours and leukemias's and offer chemotherapy, radiotherapy, stem-cell transplant and surgical treatments as required. (leedsth.nhs.uk)
  • Some high-grade monomorphic tumours, (such as Ewing's sarcoma), and some other specific tumour types cannot be graded accurately in this way and the tumour grade is defined by the specific histological type or subtype. (biomedcentral.com)
  • 80 000 cancer-related deaths per year This was a cross-sectional study of chil- sarcoma), germ cell tumours (GCTs), worldwide. (who.int)
  • Throughout the body in locations such as mucous membranes, skin, lymph nodes, thymus, and spleen are cells known as antigen-presenting cells. (wikipedia.org)
  • The biopsy specimen from the right maxillary sinus showed soft tissue infiltration with myeloid leukemic cells, consistent with a chloroma. (contemporarypediatrics.com)
  • Broadly speaking, they can be divided into Langerhans and non-Langerhans cell histiocytoses. (thedoctorsdoctor.com)
  • Langerhans cell histiocytoses are all defined by the presence of a unique ultrastructural organelle, the Birbeck granule. (thedoctorsdoctor.com)
  • Baer MR, Krantz SB, Cousar JB, Glick AD, Collins RD. Malignant histiocytoses developing in patients with b-cell lymphomas. (najms.com)
  • Our data from micro-dissected LC in both dermatopathic lymphadenopathy [12] and LCS [13] suggest that monocytes, precursor Langerhans cells, or Langerhans cells are one of the reservoir cells for MCPyV. (mayabouchenaki.com)
  • Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. (policylab.us)
  • Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. (policylab.us)
  • The antibody is a new monoclonal antibody against a C-type lectin found on the surface of Langerhans cells. (homeremedylifestyle.com)
  • They all share histologically a significant infiltration of affected tissues by langerhans cells. (scirp.org)
  • The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)
  • The BRAF gene mutation that causes this condition is somatic, meaning that it occurs during a person's lifetime and is present only in certain cells. (medlineplus.gov)
  • 13 ] have reported v-Raf murine sarcoma viral oncogene homolog B (BRAF) V600E mutations in 5 from 27 (18.5 %) cases tested. (biomedcentral.com)
  • This summary addresses squamous cell cancer of the vulva and vulvar intraepithelial neoplasias (VIN), some of which are thought to be precursors to invasive squamous cell cancers. (cancer.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines. (umassmed.edu)
  • La présente étude transversale a été menée auprès de 138 enfants atteints de cancer et traités dans l'Unité d'oncologie pédiatrique du Centre d'oncologie de l'Université de Mansoura, en Égypte. (who.int)
  • En revanche, les patients de moins de cinq ans et ceux avec un diagnostic de cancer provisoire posé initialement bénéficiaient du délai total médian le plus court. (who.int)
  • Nous suggérons de mettre en place des programmes de formation médicale continue, d'améliorer l'accès aux services de diagnostic, et de faciliter l'orientation-recours de façon à donner la priorité aux patients suspects de cancer et ainsi raccourcir le délai de diagnostic. (who.int)
  • At the age of 10, Deryn Blackwell was diagnosed with leukaemia and two years later developed a rare form of cancer called Langerhans cell sarcoma. (xpeerion.com)
  • In the most severe form of the disease, the cancer cells can spread to other parts of the body. (homeremedylifestyle.com)
  • Histologically, Langerhans cells characteristically display Birbeck granules and nuclei with a longitudinal groove. (wikipedia.org)
  • All primary malignant bone tumour cases should be discussed at a properly constituted sarcoma multidisciplinary team (MDT) meeting. (biomedcentral.com)
  • Follicular dendritic cells (FDC) form a tight meshwork in primary and secondary lymphoid follicles and interact with T and B lymphocytes through antigen presentation and generation and regulation of the germinal centre reaction [ 2 , 3 ]. (biomedcentral.com)
  • Diagnosis of Langerhans Cell Sarcoma is predominantly a pathologic diagnosis. (wikipedia.org)
  • Thus, a diagnosis is made by skin biopsy showing a large number of yeasts of uniform size and thick cell walls that form chains linked by thin bridges that are shown by staining with methenamine silver ( 2 , 4 , 9 , 18 ). (cdc.gov)
  • An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
  • Exchange transfusion therapy and its effects on real-time microcirculation in pediatric sickle cell anemia patients: an intravital microscopy study. (ucdavis.edu)
  • Comparison of real-time microvascular abnormalities in pediatric and adult sickle cell anemia patients. (ucdavis.edu)
  • Clinical factors such as a high International Prognostic Index (IPI) or molecular factors as cell of origin (COO) have an influence on the clinical outcome after conventional immunochemotherapy. (deepdyve.com)
  • The HCL-Japanese variant form (jpHCL) is rare and less well defined: there are common points with vHCL but several aspects are different in terms of morphology of hairy cells, degree of leukocytosis or clinical course. (fortuneonline.org)
  • Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. (biomedcentral.com)
  • In giant congenital melanocytic nevus, a somatic V600E mutation occurs during embryonic development in cells that will develop into pigment-producing skin cells (melanocytes). (medlineplus.gov)