A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS.
Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.
An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)
Compounds that specifically inhibit the reuptake of serotonin in the brain.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

Collagen fibrillogenesis: intermediate aggregates and suprafibrillar order. (1/50)

Polymerization of collagen in vitro has been studied with the electron microscope at early time points of fibril assembly. We have found morphologically distinct stages of aggregation, which we suggest represent successive steps in fibril formation. Linear growth of the fibril appears to occur by the tandem addition of aggregates to each other and subsequently to the ends of a subfibril; lateral growth occurs by the entwining, like a rope, of these subfibrils. Fibrillogenesis is also accompanied by extensive development of suprafibrillar order in which various patterns of parallel, spiral, and orthogonal sets of fibrils were frequently observed.  (+info)

Collagen synthesis in capsules surrounding dimethylbenzanthracene-induced rat breast tumors and the effect of pretreatment with beta-aminopropionitrile. (2/50)

Collagen synthesis is increased over three-fold in capsules surrounding dimethylbenzanthracene-induced rat breast tumors compared to the tumor parenchyma and over six-fold compared to normal breast connective tissue. Increased collagen synthesis is independent of the rate of tumor growth and final tumor size. Pretreatment of animals with beta-aminopropionitrile to inhibit collagen cross-linking caused an 82% decrease in tumor formation and a significant reduction in tumor volume (approximately 0.4 cu cm) compared to controls (approximately 10 cu cm). The four small tumors that did develop in the lathyritic animals had increased collagen synthesis in the interior tumor stroma and reduced collagen synthesis in the tumor capsule. These findings suggest that the collagenous capsule surrounding dimethylbenzanthracene tumors functions as a physical barrier to protect the tumor from the immune system of the host. The apparent antitumor effects of beta-aminopropionitrile may be due to immunopotentiation and/or cytotoxic actions of the drug.  (+info)

Analysis of the combined osteolathyritic effects of beta-aminopropionitrile and diethyldithiocarbamate on xenopus development. (3/50)

In order to examine the mechanistic basis between combined effects and mechanisms of action, two osteolathyrogens, beta-aminopropionitrile (betaAPN) and diethyldithiocarbamate (DTC), were tested together on Xenopus embryos. In a separate test, DTC was also tested with copper sulfate to determine the importance of copper in DTC-induced osteolathyrism. Frog embryos (Xenopus laevis) were exposed for 96 h, with daily solution removal and replacement. Preserved tadpoles were evaluated for osteolathyritic lesions. For the betaAPN:DTC test, a 1.2-factor matrix design was used, producing two single chemical and seven mixture-response curves. The chi(2) goodness-of-fit test was used to compare the experimental mixture-response curves with theoretical effects for two combined effects models, dose-addition and independence. All seven mixture curves were consistent with expected results for dose-addition, but the correlations were generally not high. For the DTC:copper test, the three mixture-response curves generated showed that added copper increased the DTC-alone EC(50), but there was no corresponding right shift at the top of the response curves, as observed previously with betaAPN and copper. In the betaAPN:DTC and DTC:copper tests, DTC alone showed a biphasic concentration-osteolathyrism curve, and the slope of the response curve for DTC alone in each test was statistically different than the slope for the betaAPN alone response curve. Taken together, the results suggest the potential for a second osteolathyritic effect of DTC that affected the combined toxicity enough to produce a dose-addition correlation without the chemicals necessarily having the same mechanism.  (+info)

Pattern and associated factors of the neurolathyrism epidemic in Ethiopia. (4/50)

OBJECTIVES: To describe the neurolathyrism epidemic in Ethiopia and to identify associated household factors. METHODS: We interviewed 589 randomly selected heads of household in Debre Sina district of Ethiopia, the area afflicted by the recent neurolathyrism epidemic. Disease information was obtained for 2987 family members. RESULTS: Neurolathyrism patients were detected in 56 (9.5%) households (prevalence rate 2.38%). The mean number of affected family members per household was 1.27 (SD 0.65, range 1-3). Most (77.5%) patients developed the disability during the epidemic (1995-1999). The median age at onset of paralysis was 11 years with a range of 41 (range 3-44). Younger people were more affected during the epidemic than during the non-epidemic period (P=0.01). The presence of a neurolathyrism patient in the family was associated with illiteracy [adjusted OR (95% CI)=2.23 (1.07-5.10)] of the head of household, with owning a grass pea farm [adjusted OR (95% CI)=2.01 (1.04-3.88)] and with the exclusive cooking of grass pea foods using handmade traditional clay pots [adjusted OR (95% CI=2.06 (1.08-3.90)]. CONCLUSION: Males aged 10-14 years were most affected by neurolathyrism. Increased household risk was associated with illiteracy of the head of the household and exclusive cooking of grass pea foods with handmade traditional clay pots.  (+info)

Glucosylation of galactosylhydroxylysyl residues in collagen in vitro by collagen glucosyltransferase. Inhibition by triple-helical conformation of the substrate. (5/50)

Glucosylation of galactosylhydroxylysyl residues in various collagen polypeptide chains and in small peptides prepared from collagen was studied in vitro using collagen glucosyltransferase purified about 200 to 500-fold from extract prepared from chick embryos. When various denatured polypeptide or peptide chains were compared as substrates for the enzyme, no significant differences were found between citrate-soluble collagens from normal or lathyritic rats and isolated alpha1 and alpha2 chains. In contrast, gelatinized insoluble calf skin collagen, and peptides prepared from collagen and having an average molecular weight of about 500 were clearly less effective substrates as judged from their Km and V values. A marked difference was found between native and heat-denatured citrate-soluble collagen in that no synthesis of glucosylgalactosylhydroxylysine was observed with the native collagen when the reaction was studied at 30 degrees C with different times, enzyme concentrations, and substrate concentrations. When the reaction was studied as a function of temperature, little glucosylation of native collagen was observed below 37 degrees C, but there was a sharp transition in the rate of glucosylation of native collagen at temperatures above 37 degrees C, similar to that observable in the melting curve of collagen. The data suggest that triple-helical conformation of collagen prevents that glucosylation of galactosylhydroxylysyl residues.  (+info)

Collagen metabolism in osteolathyrism in chick embryos: site of action of beta-amino-propionitrile. (6/50)

Chick embryos were sacrificed at intervals after simultaneous injection of BAPN and proline-C(14), the collagen separated into neutral salt-extractable and residue fractions, and total hydroxyproline and hydroxyproline specific radioactivity determined in each fraction. Extractable collagen, measured as hydroxyproline, increased markedly and had a higher specific activity in BAPN-treated embryos than in corresponding controls. Hydroxyproline of the residue collagen in the treated animals, however, had a lower specific activity. When proline-C(14) was injected 24 hours prior to BAPN, the specific radioactivity of the soluble collagen of treated embryos was similar to that of controls, in spite of the fact that the specific activity of the residue fraction was higher than that of the soluble fraction at the time of BAPN administration. These results suggest that the increased amount of soluble collagen in lathyrism induced by administration of BAPN does not arise from the collagen insoluble prior to administration of the drug, but rather that BAPN acts by blocking the formation of mature collagen fibers, perhaps by preventing the formation of cross-linkages between alpha-collagen chains.  (+info)

Experimental lathyrism in the chick embryo. The distribution of beta-aminopropionitrile. (7/50)

1. C(14)-labeled beta-aminopropionitrile distributed throughout the egg contents within 10 minutes postinjection. By ion exchange chromatography and electrophoretic analysis three major components of the extractable dialyzable radioactive material could be demonstrated, representing at least 80 per cent of the total. The acidic and basic components were identified as beta-aminopropionitrile and cyanoacetic acid, while the fraction isoelectric at pH 5.3, consisting of two components, remained unidentified. 2. Less than 1 molecule of betaAPN per 100 molecules of protein was present in the highly purified extractable lathyritic bone collagen indicating that binding of the lathyrogen is not a factor in collagen extractability. 3. The proximity of betaAPN to collagen in bone is not essential to its extractability. 4. The effect of incubation temperature of the embryo on collagen extractability suggests the involvement of a metabolic process in this phenomenon.  (+info)

METABOLISM OF COLLAGEN IN MAMMALIAN TISSUES. (8/50)

The amino acid composition of collagen is described and the status of knowledge about the synthesis of its unique amino acids, hydroxyproline and hydroxylysine, presented. This is followed by a schematic overview of collagen metabolism. Scurvy and lathyrism, the only two abnormalities of collagen metabolism which can now be reasonably elucidated at a molecular level, are then discussed in some detail. The paper concludes by stressing the importance of recognizing the role of histoarchitecture and of interactions of collagen with other compounds when studying collagen or its metabolism in the whole animal.  (+info)

Lathyrism is a neurological disorder caused by the consumption of large amounts of food sources containing a toxin called β-N-oxalyl-L-α,β-diaminopropionic acid (ODAP), which is found in certain legumes of the genus Lathyrus, particularly in grass peas (L. sativus). This disorder is characterized by the irreversible spastic paralysis of lower limbs due to damage in the upper motor neurons of the spinal cord. The onset and severity of lathyrism depend on the amount and duration of ODAP-containing food intake, with higher doses and longer exposure leading to more severe symptoms. Lathyrism is more prevalent in regions where grass peas are a staple food and access to diverse nutrition is limited.

Aminopropionitrile is a chemical compound with the formula NPN(H2)CH2CH2CN. It is an irritant that can cause damage to the eyes, skin, and respiratory system. It is used in the manufacture of certain plastics and resins, and has also been studied for its potential effects on the human body. Some research suggests that aminopropionitrile may interfere with the normal functioning of collagen, a protein that helps to provide structure and support to tissues and organs in the body. This has led to interest in the use of aminopropionitrile as a potential treatment for certain conditions related to collagen, such as scleroderma. However, more research is needed to determine the safety and effectiveness of this use.

Plant poisoning is a form of poisoning that occurs when someone ingests, inhales, or comes into contact with any part of a plant that contains toxic substances. These toxins can cause a range of symptoms, depending on the type and amount of plant consumed or exposed to, as well as the individual's age, health status, and sensitivity to the toxin.

Symptoms of plant poisoning may include nausea, vomiting, diarrhea, abdominal pain, difficulty breathing, skin rashes, seizures, or in severe cases, even death. Some common plants that can cause poisoning include poison ivy, poison oak, foxglove, oleander, and hemlock, among many others.

If you suspect plant poisoning, it is important to seek medical attention immediately and bring a sample of the plant or information about its identity if possible. This will help healthcare providers diagnose and treat the poisoning more effectively.

Serotonin syndrome is a potentially life-threatening condition that arises from excessive serotonergic activity in the central nervous system (CNS) and peripheral nervous system. It is typically caused by the interaction of medications, illicit substances, or dietary supplements that increase serotonin levels or enhance serotonin receptor sensitivity.

The diagnostic criteria for serotonin syndrome include:

1. Presence of a serotonergic medication or drug known to cause the syndrome
2. Development of neuromuscular abnormalities, such as hyperreflexia, myoclonus, tremor, rigidity, or akathisia
3. Autonomic dysfunction, including diaphoresis, tachycardia, hypertension, dilated pupils, and hyperthermia
4. Mental status changes, such as agitation, confusion, hallucinations, or coma
5. Symptoms that develop rapidly, usually within hours of a change in serotonergic medication or dosage

Serotonin syndrome can range from mild to severe, with the most severe cases potentially leading to respiratory failure, rhabdomyolysis, disseminated intravascular coagulation (DIC), and death. Treatment typically involves discontinuation of the offending agent(s), supportive care, and pharmacologic interventions such as cyproheptadine or cooling measures for hyperthermia.

Methylergonovine is a medication that belongs to a class of drugs called ergot alkaloids. It is primarily used to prevent and treat uterine bleeding after childbirth. Medically, it is defined as a semi-synthetic ergopeptide analog with oxytocic properties, which stimulates myometrial contractions and reduces postpartum hemorrhage.

Methylergonovine works by stimulating the smooth muscle of the uterus, causing it to contract. This helps to return the uterus to its pre-pregnancy size and also helps to control bleeding after childbirth. It is important to note that methylergonovine should only be used under the supervision of a healthcare provider, as it can have serious side effects if not used properly.

Serotonin uptake inhibitors (also known as Selective Serotonin Reuptake Inhibitors or SSRIs) are a class of medications primarily used to treat depression and anxiety disorders. They work by increasing the levels of serotonin, a neurotransmitter in the brain that helps regulate mood, appetite, and sleep, among other functions.

SSRIs block the reuptake of serotonin into the presynaptic neuron, allowing more serotonin to be available in the synapse (the space between two neurons) for binding to postsynaptic receptors. This results in increased serotonergic neurotransmission and improved mood regulation.

Examples of SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro). These medications are generally well-tolerated, with side effects that may include nausea, headache, insomnia, sexual dysfunction, and increased anxiety or agitation. However, they can have serious interactions with other medications, so it is important to inform your healthcare provider of all medications you are taking before starting an SSRI.

Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter that is found primarily in the gastrointestinal (GI) tract, blood platelets, and the central nervous system (CNS) of humans and other animals. It is produced by the conversion of the amino acid tryptophan to 5-hydroxytryptophan (5-HTP), and then to serotonin.

In the CNS, serotonin plays a role in regulating mood, appetite, sleep, memory, learning, and behavior, among other functions. It also acts as a vasoconstrictor, helping to regulate blood flow and blood pressure. In the GI tract, it is involved in peristalsis, the contraction and relaxation of muscles that moves food through the digestive system.

Serotonin is synthesized and stored in serotonergic neurons, which are nerve cells that use serotonin as their primary neurotransmitter. These neurons are found throughout the brain and spinal cord, and they communicate with other neurons by releasing serotonin into the synapse, the small gap between two neurons.

Abnormal levels of serotonin have been linked to a variety of disorders, including depression, anxiety, schizophrenia, and migraines. Medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), are commonly used to treat these conditions.

Monoamine oxidase inhibitors (MAOIs) are a class of drugs that work by blocking the action of monoamine oxidase, an enzyme found in the brain and other organs of the body. This enzyme is responsible for breaking down certain neurotransmitters, such as serotonin, dopamine, and norepinephrine, which are chemicals that transmit signals in the brain.

By inhibiting the action of monoamine oxidase, MAOIs increase the levels of these neurotransmitters in the brain, which can help to alleviate symptoms of depression and other mood disorders. However, MAOIs also affect other chemicals in the body, including tyramine, a substance found in some foods and beverages, as well as certain medications. As a result, MAOIs can have serious side effects and interactions with other substances, making them a less commonly prescribed class of antidepressants than other types of drugs.

MAOIs are typically used as a last resort when other treatments for depression have failed, due to their potential for dangerous interactions and side effects. They require careful monitoring and dosage adjustment by a healthcare provider, and patients must follow strict dietary restrictions while taking them.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Adrenergic uptake inhibitors are a class of medications that work by blocking the reuptake of neurotransmitters, such as norepinephrine and dopamine, into the presynaptic neuron. This results in an increase in the amount of neurotransmitter available to bind to postsynaptic receptors, leading to an enhancement of adrenergic transmission.

These medications are used in the treatment of various medical conditions, including depression, attention deficit hyperactivity disorder (ADHD), and narcolepsy. Some examples of adrenergic uptake inhibitors include:

* Tricyclic antidepressants (TCAs): These medications, such as imipramine and amitriptyline, were developed in the 1950s and are used to treat depression, anxiety disorders, and chronic pain.
* Selective serotonin-norepinephrine reuptake inhibitors (SNRIs): These medications, such as venlafaxine and duloxetine, were developed in the 1990s and are used to treat depression, anxiety disorders, and chronic pain.
* Norepinephrine-dopamine reuptake inhibitors (NDRIs): These medications, such as bupropion, are used to treat depression and ADHD.

It's important to note that these medications can have side effects and should be used under the supervision of a healthcare provider.

... is a condition caused by eating certain legumes of the genus Lathyrus. There are three types of lathyrism: ... "Are other systems apart from the nervous system involved in human lathyrism?" in Lathyrus sativus and Human Lathyrism: Progress ... A third type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its mechanism, employing the toxin beta- ... Mark V. Barrow; Charles F. Simpson; Edward J. Miller (1974). "Lathyrism: A Review". The Quarterly Review of Biology. 49 (2): ...
Look up lathyrism in Wiktionary, the free dictionary. Lathyrism is a class of neurological disease of humans. Lathyrism may ... This disambiguation page lists articles associated with the title Lathyrism. If an internal link led you here, you may wish to ...
"Lathyrism". Egton Medical Information Systems Limited. 22 March 2010. "Lathyrism , Doctor". patient.info. 22 March 2010. COHN, ... Another type of lathyrism is angiolathyrism which is similar to osteolathyrism in its effects on connective tissue. However, ... Lathyrism usually occurs where the combination of poverty and food insecurity leaves few other food options.[citation needed] ... Lathyrism at the Duke University Health System's Orthopedics program Detection of Toxic Lathyrus sativus flour in Gram Flour ( ...
It depicts a woman who can no longer walk due to lathyrism, surrounded by starving people waiting for bowls of grass pea-based ... The seeds contain a neurotoxin that causes lathyrism, a neurodegenerative disease, if eaten as a primary protein source for a ... Borton, Chloe (22 March 2010). "Lathyrism". Patient. EMIS Group. Edwards, Anne; Njaci, Isaac; Sarkar, Abhimanyu; Jiang, ... a disorder known as lathyrism. (Kew Gardens) Some authors have argued that this toxicity is overstated, and L. sativus is ...
Dastur, D.K. and Iyer, C.G. (1959). Lathyrism versus odoratism. Nutr. Rev. 17:33-6. Dasler, W. (1954). Observations of ... is grown for human consumption but when it forms a major part of the diet it causes symptoms of toxicity called lathyrism. In ... odoratism (sweet pea lathyrism) in the rat. Journal of Nutrition 53: 105-13. Sweet peas make a second skin - Guardian, UK, July ...
Mark V. Barrow; Charles F. Simpson; Edward J. Miller (1974). "Lathyrism: A Review". The Quarterly Review of Biology. 49 (2): ...
1974). "Lathyrism: A Review". The Quarterly Review of Biology. 49 (2): 101-128. doi:10.1086/408017. JSTOR 2820941. PMID 4601279 ... Lathyrus species contain the toxic amino acid oxalyldiaminopropionic acid and if eaten in large quantities can cause lathyrism ...
Others: Lathyrism, endemic fluorosis etc. Child malnutrition in Bangladesh is amongst the highest in the world. Two-thirds of ...
... is a form of Lathyrism disease. It is mainly caused the consumption of Lathyrus sativus (also known as grass pea ... However it is caused by similar action and is typically associated with the other forms of lathyrism.[citation needed] "Medical ... "Lathyrism". Egton Medical Information Systems Limited. 22 March 2010. (Webarchive template wayback links, Articles with short ... problems caused by plants: Lathyrism" Archived 2012-02-04 at the Wayback Machine at Prince Leopold Institute of Tropical ...
Haque, A.; Hossain, M.; Wouters, G.; Lambein, F. (1996). "Epidemiological Study of Lathyrism in Northwestern Districts of ...
This is one pea species known to cause lathyrism; nevertheless, as cicerchia it figured among the comestibles enjoyed by the ...
Arthur Kessler of Cernăuţi, reached the conclusion that the disease presented all the symptoms of lathyrism, a spastic ... By January 1943, hundreds of prisoners were suffering from lathyrism. The inmates declared a hunger strike and demanded medical ... Arthur Kessler (1903-2000)", in Lathyrus Lathyrism Newsletter, Vol. 3, pp. 3-4 Dennis Deletant Hitler's Forgotten Ally: Ion ...
... , sometimes referred to as odoratism, is a form of the disease Lathyrism. The disease results from the ingestion ... "Incisor Ash Versus Femur Ash in Sweet Pea Lathyrism (Odoratism)". The Journal of Nutrition. 54 (3): 397-402. doi:10.1093/jn/ ...
Arthur Kessler of Cernăuţi, reached the conclusion that the disease presented all the symptoms of lathyrism, a spastic ... By January 1943, hundreds of prisoners were suffering from lathyrism. 1951 - 1951 Pont-Saint-Esprit mass poisoning in France, ... Arthur Kessler (1903-2000)", in Lathyrus Lathyrism Newsletter, Vol. 3, pp. 3-4; Dennis Deletant, Hitler's Forgotten Ally: Ion ...
Lathyrism in Bangladesh: an agro-economic survey of two Lathyrismprone areas. Rajshahi: Dept. of Economics, Rajshahi University ... 1980 Lathyrism in Bangladesh : an agro-economic survey of two Lathyrismprone areas - Publish: 1986. Engineer, Nazmus Shahadat ...
It is the neurotoxin responsible for the motor neuron degeneration syndrome lathyrism. ODAP is found in the seeds of the legume ...
The Partial Exception-2020-PantaRhei-Bandcamp, Trashfuck Rec.- cdr The Tide of Unreason-2020-PantaRhei-Bandcamp Lathyrism-2020- ...
Lathyrism may be caused by oxalyldiaminopropionic acid (ODAP) poisoning from seeds of Hedysarum alpinum. The ODAP, a toxic ... a concentration well within the levels known to cause lathyrism in humans, although the interpretation of the results has been ... and are thus highly susceptible to the incapacitating effects of lathyrism after ingesting the neurotoxin". In March 2015, ... forward the proposal that McCandless starved to death because he was suffering from paralysis in his legs induced by lathyrism ...
... containing an enzyme that interferes with collagen synthesis to cause the disease Lathyrism. Lathyrus niger is a perennial ...
It depicts a woman who can no longer walk due to lathyrism, surrounded by starving people waiting for bowls of grass pea-based ... Grass peas, which grow well in dry conditions, can be toxic if eaten over a long period, causing lathyrism. Grass-pea products ...
This resulted in lathyrism, characterized by poor bone formation and strength, hyperextensible skin, weak ligaments, and ...
... but its use as a staple food will cause lathyrism even in these animals. Moreover, common vetch as well as broad bean - and ...
In the late 1950s, he became interested in lathyrism and, with Charles Levene, made the critical observations that lathyrism ... lathyrism, and wound healing. In 1969, Gross was promoted to Professor of Medicine at Harvard Medical School and named ...
Konzo, a diet-based tropical neuropathy Lathyrism, a diet-based neuropathy Tropical spastic paraparesis, and infectious ...
... can result in lathyrism "a neurological disease causing paralysis of the legs". The Jiuhuang bencao originated what Joseph ...
... which can cause paralysis called lathyrism. The leaves of the plant are used in Chinese traditional medicine. "The Plant List: ...
In 1967, following studies that linked lathyrism to ODAP, Marjorie Whiting, a nutritional antrophologist, asked Arthur Bell, a ...
Lathyrism, fluorosis and Pellagra. He was the director of the Indian Council of Medical Research there he expanded research ...
The clinical symptoms are strikingly similar to those of lathyrism and also similar to tropical spastic paraparesis and ...
Lathyrism, a disease known for centuries, encompasses 2 distinct entities: a disorder of the nervous system (neurolathyrism) ...
Lathyrism is a condition caused by eating certain legumes of the genus Lathyrus. There are three types of lathyrism: ... "Are other systems apart from the nervous system involved in human lathyrism?" in Lathyrus sativus and Human Lathyrism: Progress ... A third type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its mechanism, employing the toxin beta- ... Mark V. Barrow; Charles F. Simpson; Edward J. Miller (1974). "Lathyrism: A Review". The Quarterly Review of Biology. 49 (2): ...
Learn about Lathyrism at online-medical-dictionary.org ...
Lathyrism" at Prince Leopold Institute of Tropical Medicine online database,/ref>. The lathyrism resulting from the ... lathyrism}} {{Poisoning and toxicity}} [[de:Lathyrismus]] [[fr:Lathyrisme]] [[nl:Lathyrisme]] [[sv:Lathyrism]] {{WikiDoc Help ... "Are other systems apart from the nervous system involved in human lathyrism?" in Lathyrus sativus and Human Lathyrism: ... Its use for sheep does not pose any lathyrism problems if doses do not exceed 50 percent of the ration.,ref>{{cite book, title= ...
Lathyrism, Manyastambha, Minmina, monoplegia, Muka, Over belching, Pada daha, Padaharsha, Pakshavadha, Pangu, Paraplegia, ...
Wicked Lathyrism Army of Me 2.. Jun 28, 2004:. In Your Ear... Launch of the Noon Time Performance So Broken 5.. Feb 15, 2004: ... Wicked Lathyrism Bachelorette, All Is Full of Love 6.. Jan 18, 2004:. Nothing to Sea Army of Me ...
Lathyrism Definition and Meaning. February 13, 2021 Meaning of Coaxial Cable. May 19, 2021 ...
"Bone fracture toughness and strength correlate with collagen cross-link maturity in a dose-controlled lathyrism mouse model," ...
disease, similar to lathyrism, that results in pain, burning and prickling sensations in lower ...
Im particularly thinking of the disease Lathyrism obtained from eating the seeds of certain Lathyrus spp), that contain toxins ...
... lathyrism if they are eaten in large amounts (although small quantities are said to be nutritious)[65, 76]. Great caution is ...
Arhar dal is mixed with Khesari dal which causes lathyrism, a crippling disease characterised by paralysis of the leg. Turmeric ...
... or they would suffer from a range of permanent disabilities known collectively as lathyrism. Best to stick with your frozen ...
Barrow M.V., Simpson C.F., Miller E.J. Lathyrism: A Review .Quart. Rev. Biol. 1974. 49. P. 101-128. CrossRef PubMed ... Experiments were carried out on rats with lathyrism, which was induced by adding semicarbazide (0.075%) into drinking water for ... This experimental model of lathyrism is appropriate for investigation of the lysyl oxi-dase inhibitors effect on extracellular ... Altered collagene characteristics and lysyl oxidase activity in lathyrism. Volodina TT, Dzvonkevych ND, Petrun LM, Krysiuk IP ...
Many cases of serotonin toxicity occur in people who have ingested drug combinations that synergistically increase synaptic serotonin.[10] It may also occur due to an overdose of a single serotonergic agent.[27] The combination of monoamine oxidase inhibitors (MAOIs) with precursors such as L-tryptophan or 5-hydroxytryptophan pose a particularly acute risk of life-threatening serotonin syndrome.[28] The case of combination of MAOIs with tryptamine agonists (commonly known as ayahuasca) can present similar dangers as their combination with precursors, but this phenomenon has been described in general terms as the cheese effect. Many MAOIs irreversibly inhibit monoamine oxidase. It can take at least four weeks for this enzyme to be replaced by the body in the instance of irreversible inhibitors.[29] With respect to tricyclic antidepressants, only clomipramine and imipramine have a risk of causing SS.[30] Many medications may have been incorrectly thought to cause SS. For example, some case reports ...
LATHYRISM] 65. ԼԱՏԵՔՍ [LATEX] 16. ԼԱԿՏԱԴԵՀԻԴՐՈԳԵՆԱԶ [LACTATE DEHYDROGENASE] 66. ԼԱՏԵՔՍ ՍՏՈՒԳԱՆԻՇ [LATEX FIXATION TESTS] ...
Lathyrism MeSH DeCS ID:. 641 Unique ID:. D000629 Documents indexed in the Virtual Health Library (VHL):. Click here to access ...
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lathyrism Lathrop, Rose Hawthorne (1851-1926) Lathrop, Rose Hawthorne Lathrop, Philip H. ...
5. Lathyrism.. 6. Tandem bullet.. February 2022 :. I. Elaborate on: (1 x 10 = 10). 1. Enumerate the parameters to determine the ...
Lathyrism: A Review. The Quarterly Review of Biology 49: 101-128. 396 : Hempel, K. A. 2004. Advantages of chasmogamy and ...
Lathyrus Lathyrism Newsletter 4: 7-9.. This resource would not be possible without the input from the following people from the ...
Lathyrism is often irreversible, but not fatal. Lathyrism seems to occur when food ratios containing at least 25% chickling pea ... The onset of lathyrism can be slow or sudden, and is often indicated by a feeling of heaviness and pain in the lower limbs. ... lathyrism. ODAP is present in all parts of the plant and affects various parts of the central nervous system, disrupting ...
Nutritional problems in public health- Undernutrition, Lathyrism. *Assessment of nutritional status. *Milk Hygiene ...
The Lathyrism problem : current status and new dimensions. Series: Scientific report (Nutrition Foundation of India) ; 2 ...
... and lathyrism (poisoning by members of the pea family like Sweet Pea). ...
Only nine old cases of lathyrism were found during the study. The mean ß-ODAP content in SGP was 0.63â ¯±â ¯0.14, 0.65â ¯±â ¯ ... Lathyrism is a disease caused by excessive consumption of grass pea, Lathyrus sativus especially under conditions of severe ... Due to awareness of the disease, availability of food and levels of consumption of L. sativus there is reduction in lathyrism ... Current scenario of consumption of Lathyrus sativus and lathyrism in three districts of Chhattisgarh State, India. ...
The nutritive values of some legumes, Lathyrism in the rat. The sweet pea (Lathyrus odoratus), Lathyrus sativus, Lathyrus ...
The Toxic Factor of Lathyrus Sativus and Experimental Lathyrism in Animals 141-ii. M.N. Rudra. View ...
  • There are three types of lathyrism: neurolathyrism, osteolathyrism, and angiolathyrism, all of which are incurable, differing in their symptoms and in the body tissues affected. (wikipedia.org)
  • Lathyrism produces poorly cross-linked Collagen in healing anastomosis, keeping a larger portion of the synthesized Collagen soluble. (istanbul.edu.tr)
  • Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme that is essential for interfibrillar collagen cross-linking. (omu.edu.tr)
  • Defective collagen metabolism such as lathyrism may negatively influence the interface between implant and surrounding soft tissue attachment. (omu.edu.tr)
  • The onset of lathyrism can be slow or sudden, and is often indicated by a feeling of heaviness and pain in the lower limbs. (theferns.info)
  • Therefore, the purpose of this study was to assess the effect of defective connective tissue metabolism on epithelial implant interface by using beta-APN created chronic lathyrism in the canine model. (omu.edu.tr)
  • Lathyrism is a condition caused by eating certain legumes of the genus Lathyrus. (wikipedia.org)
  • Some states in India have banned the sale of Lathyrus seed in order to prevent its consumption, which in turn lessens the possibility of lathyrism in the general population. (wikipedia.org)
  • in Lathyrus sativus and Human Lathyrism: Progress and Prospects. (wikipedia.org)
  • Chronic cyanide poisoning is thought to be a form of lathyrism, a neurotoxicity recognized in people in some eastern Asian countries where the seeds of certain peas (Lathyrus spp. (equinegutflush.com)
  • Historically the grass pea is known to produce adverse side effects with excessive human consumption which exacerbates the risk of a neurological disorder known as lathyrism which can cause permanent paralysis below the knees both in adults and children. (livingfield.co.uk)
  • Medical problems caused by plants: Lathyrism" Archived 2012-02-04 at the Wayback Machine at Prince Leopold Institute of Tropical Medicine online database COHN, D.F. (1995) "Are other systems apart from the nervous system involved in human lathyrism? (wikipedia.org)
  • Although no records of toxicity have been found for this plant, the seed of some species in this genus contain a toxic amino acid that can cause a severe disease of the nervous system known as 'lathyrism' if they are eaten in large amounts (although small quantities are said to be nutritious)[65, 76]. (pfaf.org)
  • Arhar dal is mixed with Khesari dal which causes lathyrism, a crippling disease characterised by paralysis of the leg. (thestatesman.com)
  • Glutamate excitotoxicity is associated with diseases like amyotrophic lateral sclerosis, multiple sclerosis, lathyrism, and Alzheimer's disease (PMID: 20229265) and in epileptic seizures. (foodb.ca)
  • A plant genus in the family FABACEAE known for LATHYRISM poisoning. (nih.gov)
  • Congenital forms are believed to be due to mare factors including malpositioning of the foetus, influenza during pregnancy, thyroid problems, and lathyrism (poisoning by members of the pea family like Sweet Pea). (horsepower.com.au)
  • Barrow M.V., Simpson C.F., Miller E.J. Lathyrism: A Review .Quart. (kiev.ua)
  • This experimental model of lathyrism is appropriate for investigation of the lysyl oxi-dase inhibitors effect on extracellular matrix. (kiev.ua)
  • Lathyrism cases were identified using a case definition of symmetrical spastic leg weakness, and subacute or insidious onset, with no sensory deficit, and with a history of grass pea consumption before and at the onset of paralysis. (nih.gov)
  • Studies had linked lathyrism to consumption of certain species of legumes that contained the compound β- N -oxalylamino-ʟ-alanine (BOAA). (nih.gov)
  • Osteolathyrism, a different type of lathyrism, affects the connective tissues, not the motor neurons. (wikipedia.org)
  • Because collagens and elastin are important components of the extracellular matrix, abnormalities in their modification can be expected to affect many tissues, as seen in lathyrism, a connective tissue disorder caused by the administration of ß-aminopropionitrile, an irreversible inhibitor of lysyl oxidases. (adhd-npf.com)
  • Lathyrism, leg cramps, and thrombocytopenia: cascade of events starting in a concentration camp. (nih.gov)
  • citation needed] Eating the grasspea with legumes having high concentrations of sulphur-based amino acids reduces the risk of lathyrism if such grain is available. (wikipedia.org)
  • The discovery was serendipitous, an offshoot of research on lathyrism, a progressive paralysis of the legs found in people in China, India, and the Middle East. (nih.gov)
  • Lathyrism is a disease of the Muscles of the Legs. (herbpathy.com)
  • Enzymatic crosslinking can be limited by compounds such as β-aminopropionitrile (BAPN) and result in a crosslink deficiency characterizing a disease known as lathyrism. (purdue.edu)
  • The Lathyrism problem : current status and new dimensions. (who.int)
  • A third type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its mechanism, employing the toxin beta-aminopropionitrile. (wikipedia.org)
  • In the experimental group, lathyrism was induced by a once daily subcutaneous administration of beta-APN at a dose of 5mg in 0.4ml distilled water per 100g of body weight for 40 days. (bvsalud.org)