A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
Tumors or cancer of the UTERUS.
The smooth muscle coat of the uterus, which forms the main mass of the organ.
A relatively rare smooth muscle tumor found most frequently in the wall of the gastrointestinal tract, especially in the stomach. It is similar to other smooth muscle tumors but may become very large and hemorrhage and exhibit small cystic areas. Simple excision is almost always curative. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)
The state of having multiple leiomyomas throughout the body. (Stedman, 25th ed)
A benign tumor consisting of vascular and smooth muscle elements.
Surgical removal of a LEIOMYOMA of the UTERUS.
A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
Excision of the uterus.
A tumor composed of smooth muscle tissue, as opposed to leiomyoma, a tumor derived from smooth muscle.
Pregnadienes which have undergone ring contractions or are lacking carbon-18 or carbon-19.
The use of embolizing agents to block the arterial blood supply to parts or all of the UTERUS. The procedures are done to control bleeding or to cause destruction of uterine tissues.
Excessive uterine bleeding during MENSTRUATION.
Food that has been prepared and stored in a way to prevent spoilage.
A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
A group of proteins that covalently attach to selenium or SELENIUM-containing compounds.

Epithelioid leiomyoma of the vulva. (1/5)

Smooth muscle tumors are uncommon lesions of the vulva and represent a variety of histologic types. When encountered, surgical treatment is guided by the malignant potential of the tumors. This article presents the case of a 45-year-old woman who underwent conservative excision of a 10-cm vulvar lesion consistent with benign epithelioid leiomyoma. This unusual case provides an opportunity to review the clinical and pathologic features of this uncommon variant of leiomyoma and to describe the recently suggested pathologic criteria for determining the malignant potential of smooth muscle tumors arising in the vulva. Knowledge of these criteria can guide the clinician in selecting the appropriate management.  (+info)

Endosonographic features predictive of benign and malignant gastrointestinal stromal cell tumours. (2/5)

BACKGROUND/AIM: Some endoscopic ultrasonographic (EUS) features have been reported to be suggestive of malignancy in gastrointestinal stromal cell tumours (SCTs). The aim of this study was to assess the predictive value of these features for malignancy. METHODS: A total of 56 histologically proven cases of SCT studied by EUS between 1989 and 1996 were reviewed. There were 42 gastric tumours, 12 oesophageal tumours, and two rectal tumours. The tumours were divided into two groups: (a) benign SCT, comprising benign leiomyoma (n = 34); (b) malignant or borderline SCT (n = 22), comprising leiomyosarcoma (n = 9), leiomyoblastoma (n = 9), and leiomyoma of uncertain malignant potential (n = 4). The main EUS features recorded were tumour size, ulceration, echo pattern, cystic spaces, extraluminal margins, and lymph nodes with a malignant pattern. The two groups were compared by univariate and multivariate analysis. RESULTS: Irregular extraluminal margins, cystic spaces, and lymph nodes with a malignant pattern were most predictive of malignant or borderline SCT. Pairwise combinations of the three features had a specificity and positive predictive value of 100% for malignant or borderline SCT, but a sensitivity of only 23%. The presence of at least one of these three criteria had 91% sensitivity, 88% specificity, and 83% predictive positive value. In multivariate analysis, cystic spaces and irregular margins were the only two features independently predictive of malignant potential. The features most predictive of benign SCTs were regular margins, tumour size < or = 30 mm, and a homogeneous echo pattern. When the three features were combined, histology confirmed a benign SCT in all cases. CONCLUSIONS: The combined presence of two out of three EUS features (irregular extraluminal margins, cystic spaces, and lymph nodes with a malignant pattern) had a positive predictive value of 100% for malignant or borderline gastrointestinal SCT. Tumours less than 30 mm in diameter with regular margins and a homogeneous echo pattern are usually benign.  (+info)

Endoscopic ultrasound-guided fine-needle aspiration findings of gastrointestinal leiomyomas and gastrointestinal stromal tumors. (3/5)

True leiomyomas of the gastrointestinal system are rare but remain the most common mesenchymal tumors of the esophagus. It has become important to distinguish these tumors from gastrointestinal stromal tumors (GISTs) because the neoplasms have different prognoses and treatment options. We describe and compare clinical findings and the following fine-needle aspiration (FNA) features of 9 gastrointestinal leiomyomas and 19 GISTs sampled with endoscopic ultrasound: overall cellularity, cell group features, cell shape and cytoplasmic features, nuclear characteristics, background, cell block features, and immunohistochemical results. Gastrointestinal leiomyomas and GISTs have different clinical and cytologic features that help pathologists distinguish these tumors, and the immunohistochemical findings that help define these lesions can be derived readily from cell block material obtained by endoscopic ultrasound-guided FNA.  (+info)

Pathological characteristics of gastric leiomyoblastoma. (4/5)

AIM: To determine the pathological characteristics of gastric leiomyoblastoma. METHODS: All tissues were obtained during surgery or gastroscopy. Tissue specimens for examination by light microscope were 1 cm x 1 cm x 1 cm in size, fixed in 40 g/L neutral buffered formaldehyde, embedded in paraffin, and stained with hematoxylin and eosin. The fresh tissues obtained for electron microscopy were 1 mm x 1 mm x 1 mm in size, and fixed in phosphate buffered 30 g/L glutaraldehyde, postfixed in 10 g/L osmium tetroxide and dehydrated in graded alcohol, embebbed in Epon 812. Ultrathin sections of 50 nm were stained with uranyl acetate and lead citrate and examined under a JEM-2000 EX transmission electron microscope. RESULTS: The most important histopathological feature of leiomyoblastoma was the predominance of large, rounded or polygonal cells with characteristic perinuclear clear zone in cytoplasms. The tumor cells arranged in patch, cell junction or junctional complex could be found occasionally between cells under electron microscope. Most of the neoplastic cytoplasms were filled with myofilaments, dense bodies, and dense patches. Rough endoplasmic reticulum dilatated as lakes, and large quantities of protein secretions of intermediate electron density were found in the dilated cisternae. Intracisternal segregation could also be found. The nuclei were round or oval, and anomalous nuclei were found in part of cells. CONCLUSION: The diagnosis of gastric leiomyoblastoma can be confirmed by electron microscopy. The clear appearance of tumor cells is due to the dilation of rough endoplasmic reticulum, not fat droplets, glycogens or mucus in cytoplasm.  (+info)

Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids. (5/5)

 (+info)

Leiomyoma is a benign (non-cancerous) tumor that originates from the smooth muscle cells. It most commonly occurs in the uterus, where it is also known as a fibroid, but can also develop in other parts of the body such as the skin, gastrointestinal tract, and genitourinary system. Leiomyomas are typically slow-growing and often cause no symptoms, although they can lead to various complications depending on their size and location. Treatment options for leiomyomas include surveillance, medication, or surgical removal.

Uterine neoplasms refer to abnormal growths in the uterus, which can be benign (non-cancerous) or malignant (cancerous). These growths can originate from different types of cells within the uterus, leading to various types of uterine neoplasms. The two main categories of uterine neoplasms are endometrial neoplasms and uterine sarcomas.

Endometrial neoplasms develop from the endometrium, which is the inner lining of the uterus. Most endometrial neoplasms are classified as endometrioid adenocarcinomas, arising from glandular cells in the endometrium. Other types include serous carcinoma, clear cell carcinoma, and mucinous carcinoma.

Uterine sarcomas, on the other hand, are less common and originate from the connective tissue (stroma) or muscle (myometrium) of the uterus. Uterine sarcomas can be further divided into several subtypes, such as leiomyosarcoma, endometrial stromal sarcoma, and undifferentiated uterine sarcoma.

Uterine neoplasms can cause various symptoms, including abnormal vaginal bleeding or discharge, pelvic pain, and difficulty urinating or having bowel movements. The diagnosis typically involves a combination of imaging tests (such as ultrasound, CT, or MRI scans) and tissue biopsies to determine the type and extent of the neoplasm. Treatment options depend on the type, stage, and patient's overall health but may include surgery, radiation therapy, chemotherapy, or hormone therapy.

The myometrium is the middle and thickest layer of the uterine wall, composed mainly of smooth muscle cells. It is responsible for the strong contractions during labor and can also contribute to bleeding during menstruation or childbirth. The myometrium is able to stretch and expand to accommodate a growing fetus and then contract during labor to help push the baby out. It also plays a role in maintaining the structure and shape of the uterus, and in protecting the internal organs within the pelvic cavity.

Epithelioid Leiomyoma is a rare type of benign (non-cancerous) smooth muscle tumor. It arises from the muscularis mucosa or the smooth muscle layer of blood vessels in the gastrointestinal tract, particularly in the esophagus and stomach.

Epithelioid Leiomyomas are composed of epithelioid cells, which have an appearance similar to epithelial cells, but they are actually smooth muscle cells with an altered shape and size. These tumors typically appear as well-circumscribed masses, and they usually do not invade surrounding tissues or metastasize (spread) to other organs.

The diagnosis of Epithelioid Leiomyoma is based on histopathological examination, which involves the examination of tissue samples under a microscope. Immunohistochemical staining may also be used to confirm the presence of smooth muscle markers and exclude other malignant tumors with similar morphology.

Treatment typically involves surgical excision of the tumor, and the prognosis is generally excellent, with a low risk of recurrence. However, close follow-up is recommended to monitor for any potential recurrences or changes in the tumor's behavior.

Leiomyomatosis is a medical term that refers to the benign growth (non-cancerous) of smooth muscle cells, which form tumors known as leiomyomas or fibroids. These growths can occur in various parts of the body, including the skin, uterus, gastrointestinal tract, and other organs.

The term "leiomyomatosis" is often used to describe a condition where multiple smooth muscle tumors develop in a single organ or throughout the body. For example:

1. Cutaneous leiomyomatosis - Multiple benign tumors of the smooth muscle in the skin.
2. Uterine leiomyomatosis - Multiple fibroids in the uterus, also known as uterine fibroids or myomas.
3. Gastrointestinal stromal tumor (GIST) leiomyomatosis - Multiple benign smooth muscle tumors in the gastrointestinal tract.
4. Disseminated peritoneal leiomyomatosis - Multiple benign smooth muscle tumors spread across the peritoneum, the lining of the abdominal cavity.

These conditions are usually not cancerous but can cause various symptoms depending on their location and size. Treatment options may include surveillance, medication, or surgical removal of the tumors.

An angiomyoma is a benign tumor that is composed of both blood vessels and smooth muscle cells. It is also known as a vascular leiomyoma. These types of tumors can occur in various parts of the body, but when they occur in the uterus, they are often referred to as fibroids. Angiomyomas are typically slow-growing and asymptomatic, but in some cases, they may cause symptoms such as heavy menstrual bleeding, pelvic pain, or pressure on surrounding organs. Treatment options for angiomyomas may include observation, medication, or surgical removal.

A uterine myomectomy is a surgical procedure that involves removing uterine fibroids, which are noncancerous growths that develop in the muscular wall of the uterus. The surgery aims to preserve the uterus, unlike a hysterectomy, where the entire uterus is removed.

During the myomectomy procedure, the surgeon makes an incision in the uterus, carefully extracts the fibroids, and then closes the incision. The approach to the surgery can vary depending on factors such as the size, number, and location of the fibroids:

1. Abdominal myomectomy: An open surgical procedure where an incision is made in the lower abdomen to access the uterus directly. This method is typically used when there are numerous or large fibroids.
2. Laparoscopic myomectomy: A minimally invasive procedure that involves making several small incisions in the abdomen, through which a laparoscope (a thin, lighted tube with a camera) and specialized surgical instruments are inserted to perform the surgery. This method is often preferred for smaller fibroids and when preserving the uterus is essential.
3. Hysteroscopic myomectomy: Another minimally invasive procedure that involves inserting a hysteroscope through the cervix into the uterine cavity to remove submucosal fibroids (fibroids that grow into the inner cavity of the uterus). No abdominal incisions are required for this approach.

Recovery time and postoperative discomfort will vary depending on the type of myomectomy performed, but generally, minimally invasive procedures result in quicker recoveries and fewer complications compared to open surgeries.

Leiomyosarcoma is a type of cancer that arises from the smooth muscle cells, which are responsible for the involuntary contractions of various organs and blood vessels. It most commonly occurs in the uterus, soft tissues (such as muscles and fat), and the gastrointestinal tract.

Leiomyosarcomas can vary in their aggressiveness and may spread to other parts of the body (metastasize) through the bloodstream or lymphatic system. The prognosis for leiomyosarcoma depends on several factors, including the location and size of the tumor, the patient's age and overall health, and the extent of metastasis. Treatment typically involves surgical removal of the tumor, along with radiation therapy and/or chemotherapy to help prevent recurrence or spread of the cancer.

A hysterectomy is a surgical procedure that involves the removal of the uterus (womb). Depending on the specific medical condition and necessity, a hysterectomy may also include the removal of the ovaries, fallopian tubes, and surrounding tissues. There are different types of hysterectomies, including:

1. Total hysterectomy: The uterus and cervix are removed.
2. Supracervical (or subtotal) hysterectomy: Only the upper part of the uterus is removed, leaving the cervix intact.
3. Radical hysterectomy: This procedure involves removing the uterus, cervix, surrounding tissues, and the upper part of the vagina. It is typically performed in cases of cervical cancer.
4. Oophorectomy: The removal of one or both ovaries can be performed along with a hysterectomy depending on the patient's medical condition and age.
5. Salpingectomy: The removal of one or both fallopian tubes can also be performed along with a hysterectomy if needed.

The reasons for performing a hysterectomy may include but are not limited to: uterine fibroids, heavy menstrual bleeding, endometriosis, adenomyosis, pelvic prolapse, cervical or uterine cancer, and chronic pelvic pain. The choice of the type of hysterectomy depends on the patient's medical condition, age, and personal preferences.

A smooth muscle tumor refers to a growth that develops in the smooth muscles, which are involuntary muscles found in various organs and structures throughout the body, including the digestive tract, uterus, blood vessels, and bladder. These tumors can be benign (noncancerous) or malignant (cancerous).

Benign smooth muscle tumors are called leiomyomas. They are typically slow-growing and rarely spread to other parts of the body. Leiomyomas are often asymptomatic but can cause problems depending on their location. For instance, a leiomyoma in the uterus might lead to heavy menstrual periods or difficulty becoming pregnant.

Malignant smooth muscle tumors are called leiomyosarcomas. These tumors are more aggressive and have a higher risk of spreading to other parts of the body. Symptoms can vary widely depending on the location of the tumor but may include abdominal pain, bloating, or bleeding.

It's important to note that while some smooth muscle tumors can be removed surgically, others may require additional treatment such as radiation therapy or chemotherapy, especially in cases of leiomyosarcomas. Regular follow-up with a healthcare provider is essential to monitor for recurrence and manage any potential complications.

Norpregnadienes are a type of steroid hormone that are structurally similar to progesterone, but with certain chemical groups (such as the methyl group at C10) removed. They are formed through the metabolism of certain steroid hormones and can be further metabolized into other compounds.

Norpregnadienes have been studied for their potential role in various physiological processes, including the regulation of reproductive function and the development of certain diseases such as cancer. However, more research is needed to fully understand their functions and clinical significance.

Uterine artery embolization (UAE) is a minimally invasive procedure used to treat certain conditions related to the uterus and uterine fibroids. The procedure involves blocking or reducing the blood flow to the fibroids, causing them to shrink and alleviating symptoms such as heavy menstrual bleeding, pain, and pressure.

During the procedure, an interventional radiologist makes a small incision in the groin area and inserts a catheter into the femoral artery. The catheter is then guided to the uterine arteries using fluoroscopic imaging. Once in place, tiny particles are injected through the catheter to block or reduce the blood flow to the fibroids. This process may be performed on one or both uterine arteries, depending on the location and size of the fibroids.

UAE is typically an outpatient procedure, and most women can return home the same day. Recovery time varies but is generally shorter than that of a hysterectomy, which is the surgical removal of the uterus. Potential risks associated with UAE include infection, bleeding, damage to nearby organs, and premature menopause in some cases. However, these complications are relatively rare.

Menorrhagia is a medical term used to describe abnormally heavy or prolonged menstrual periods. It's often characterized by the loss of an excessive amount of menstrual blood (usually more than 80 ml) and can last longer than normal, typically over seven days. This condition can have significant impacts on a woman's quality of life, causing fatigue, distress, and restrictions in daily activities due to the need for frequent pad or tampon changes.

The causes of menorrhagia are varied and can include hormonal imbalances, uterine fibroids or polyps, endometrial hyperplasia, pelvic inflammatory disease, pregnancy complications, certain medications, and underlying medical conditions such as coagulopathies or thyroid disorders. In some cases, the cause may remain undetermined even after a thorough evaluation.

Treatment options for menorrhagia depend on the underlying cause and range from medication management with hormonal therapies, nonsteroidal anti-inflammatory drugs (NSAIDs), or tranexamic acid to procedural interventions like endometrial ablation, hysteroscopic resection of polyps or fibroids, or ultimately hysterectomy in severe cases. It is essential for individuals experiencing menorrhagia to consult with their healthcare provider to determine the best course of action based on their specific situation and medical history.

Preserved food, in a medical context, refers to food that has been treated or processed in order to inhibit spoilage and prolong its shelf life. This is typically achieved through methods such as canning, pickling, smoking, drying, or freezing. These processes work by reducing the moisture content, increasing acidity, or introducing chemicals that prevent the growth of bacteria, fungi, and other microorganisms that can cause foodborne illness.

While preserved foods can be a valuable source of nutrition, especially in situations where fresh food is not available, it's important to note that some preservation methods can also introduce harmful substances, such as sodium nitrite in cured meats or acrylamide in fried or baked starchy foods. Therefore, preserved foods should be consumed in moderation as part of a balanced diet.

Transforming Growth Factor-beta 3 (TGF-β3) is a type of cytokine, specifically a growth factor that belongs to the TGF-β family. It plays crucial roles in regulating various cellular processes such as proliferation, differentiation, apoptosis, and extracellular matrix production.

TGF-β3 has been identified to have significant functions during embryonic development and tissue repair. In particular, it is known to be involved in the regulation of wound healing and scar formation. TGF-β3 can influence the behavior of various cell types, including fibroblasts, epithelial cells, and immune cells.

In some cases, TGF-β3 has been investigated for its potential therapeutic use in reducing fibrosis and promoting tissue regeneration. However, more research is needed to fully understand its mechanisms and potential clinical applications.

Selenium-binding proteins (Se-binding proteins) are a group of proteins that contain selenocysteine, an amino acid containing selenium. Selenocysteine is incorporated into these proteins at specific positions during protein synthesis, and it plays a crucial role in the function of Se-binding proteins.

One of the most well-known Se-binding proteins is glutathione peroxidase (GPx), an antioxidant enzyme that protects cells from oxidative damage by reducing hydrogen peroxide and lipid peroxides to water and alcohols, respectively. Other Se-binding proteins include thioredoxin reductase, which plays a role in redox regulation, and iodothyronine deiodinases, which are involved in thyroid hormone metabolism.

Se-binding proteins have been identified in various organisms, including bacteria, archaea, and eukaryotes. In humans, Se-binding proteins are found in a variety of tissues, including the liver, kidney, and brain. The expression and activity of Se-binding proteins can be influenced by factors such as selenium status, oxidative stress, and inflammation.

Iglesias C, Torrelo A, Colmenero I, Mediero IG, Zambrano A, Requenca L. Isolated multiple congential epithelioid blue naevus. ... In addition to these three classical tumors, there is an increased incidence of pheochromocytoma, esophageal leiomyoma and ... "The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year ... The original description employed the then-prevailing terminology of gastric epithelioid leiomyosarcoma. Subsequent advances in ...
Leiomyosarcoma Fibrous histiocytoma Proximal epithelioid sarcoma Alveolar soft part sarcoma Liposarcoma Dermatofibrosarcoma ... Hidradenoma papilliferum Anogential mammary-like glands Endometriosis Hemangioma Fibroma Lipoma Granular cell tumor Leiomyoma ... protuberans Deep angiomyxoma Superficial angiomyxoma Angiomyofibroblastoma Cellular angiofibroma Leiomyoma Granular cell Tumor ...
... leiomyoma MeSH C04.557.450.590.450.125 - angiomyoma MeSH C04.557.450.590.450.455 - leiomyoma, epithelioid MeSH C04.557.450.590. ... epithelioid and spindle cell MeSH C04.557.695.065 - ameloblastoma MeSH C04.557.695.210 - cementoma MeSH C04.557.695.605 - ... epithelioid MeSH C04.557.645.375.380 - hemangioma, capillary MeSH C04.557.645.375.380.370 - hemangioblastoma MeSH C04.557. ...
Epithelioid cell histiocytoma Epithelioid hemangioendothelioma Epithelioid sarcoma Erythrodermic mastocytosis Extraskeletal ... Multiple cutaneous leiomyoma (pilar leiomyoma) Neural fibrolipoma Neuroblastoma (infantile neuroblastoma, neuroepithelioma) ... Ganglion cyst Ganglioneuroma Gardner fibroma Genital leiomyoma (dartoic leiomyoma) Giant cell fibroblastoma Giant cell tumor of ... Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma, histiocytoid hemangioma, inflammatory angiomatous nodule, ...
0 Epithelioid leiomyoma Leiomyoblastoma M8891/3 Epithelioid leiomyosarcoma M8892/0 Cellular leiomyoma M8893/0 Bizarre leiomyoma ... cell nevus of Reed M8770/3 Mixed epithelioid and spindle cell melanoma M8771/0 Epithelioid cell nevus M8771/3 Epithelioid cell ... Pleomorphic cell sarcoma M8803/3 Small cell sarcoma Round cell sarcoma M8804/3 Epithelioid sarcoma Epithelioid cell sarcoma ... NOS Fetal lipomatosis Lipoblastoma M8890/0 Leiomyoma, NOS Fibroid uterus (C55.9) Fibromyoma Leiomyofibroma Plexiform leiomyoma ...
For example, a benign tumor of smooth muscle cells is called a leiomyoma (the common name of this frequently occurring benign ... cancer Thymoma and thymic carcinoma Squamous-cell carcinoma of the lung AIDS-related cancers Kaposi sarcoma Epithelioid ...
Several histologic subtypes exist, including usual (spindled), epithelioid, and myxoid tumors. ... they range from benign leiomyomas to low-grade and high-grade leiomyosarcomas. ... Leiomyoma with atypia (formerly called symplastic leiomyoma). Note the focal nature of the severe atypia. By definition, tumors ... Leiomyoma with atypia (formerly called symplastic leiomyoma). Note the focal nature of the severe atypia. By definition, tumors ...
Iglesias C, Torrelo A, Colmenero I, Mediero IG, Zambrano A, Requenca L. Isolated multiple congential epithelioid blue naevus. ... In addition to these three classical tumors, there is an increased incidence of pheochromocytoma, esophageal leiomyoma and ... "The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year ... The original description employed the then-prevailing terminology of gastric epithelioid leiomyosarcoma. Subsequent advances in ...
Bladder Perivascular Epithelioid Cell Tumor: A Novel Rare Neoplasm Urol Int (November,2011) ... Hepatic Myxoid Leiomyoma: A Very Rare Tumor GE Port J Gastroenterol (December,2019) ...
This case was determined to be an epithelioid leiomyoma. I didnt do electron microscopy to look for mitochondia, but it may ... have called a mitochondria-rich epithelioid leiomyoma (Arch Ophthalmol, Vol 120, January 2002). ...
Previously, these tumors were classified as GI leiomyomas, leiomyosarcomas, leiomyoblastomas, or schwannomas, on the basis of ... Epithelioid GISTs may have either a solid pattern or a myxoid pattern, with a possible compartmental pattern. Although GISTs ... Gastrointestinal Stromal Tumors (Leiomyoma/Leiomyosarcoma) Imaging * Sections Gastrointestinal Stromal Tumors (Leiomyoma/ ... 4] Only with tumors in the esophagus does the term leiomyoma remain accurate. Leiomyomas are the most common mesenchymal tumors ...
... epitheloid gastrointestinal stromal tumor is regarded as a rare malignancy that should be distinguished from leiomyomas and ... Our case was also presented as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor ... Histopathology report showed the retroperitoneal mass to be a malignant epithelioid gastrointestinal tumor. Her cytology report ... to epithelioid (20% - 30%) or mixed. Gastrointestinal stromal tumours (GISTs) were initially presumed to be of "true" smooth ...
Cystic clear cell epithelioid leiomyoma: An unusual presentation. Singh, V. K., Shetty, T. & Singh, B. M. K., 01-10-2019, In: ... Primary Adrenal Epithelioid Sarcoma in a Child: A Case Report with Literature Review. Monappa, V., Singh, V. K. & Chawla, A., ... Xanthogranulomatous Degeneration in a Leiomyoma - First Documentation. Singh, V. K., Rasheed, H., Singh, B. M. K. & Guruvare, S ...
Epithelioid leiomyoma (morphologic abnormality). Code System Preferred Concept Name. Epithelioid leiomyoma (morphologic ...
... epithelioid smooth muscle tumors, benign metastasizing leiomyomas, intravenous leiomyomatosis, diffuse leiomyomatosis," and ... and perivascular epithelioid cell neoplasm (PEComa).3 Carcinosarcomas were previously categorized and included in the sarcoma ...
Malignant transformation may have malignant epithelioid cells and rarely shows divergent differentiation as angiosarcoma-like ... Uterine leiomyoma was first discovered by Hippocrates in 460-375 B.C and called it "uterine stone". Uterine leiomyoma may be ... Differentiating Leiomyoma from other Diseases. Differentiating Leiomyoma from Other Diseases Disease entity Etiology (Genetic ... Pelvic ultrasound is helpful in the diagnosis of uterine leiomyoma.. *Findings on an ultrasound diagnostic of uterine leiomyoma ...
Epithelioid leiomyoma. Post navigation. Previous PostWeek 237: Case 6Next PostWeek 238: Case 2 ...
epithelioid angiomyolipoma* leiomyoma* hemangioma* juxtaglomerular cell tumor* renomedullary interstitial cell tumor* ...
Epithelioid Leiomyoma of Vagina. The Effect Of Gardnerella Vaginalis On Infertility And Pregnancy Of Albino Rats ...
... PubMed, SCI, Scopus, ESCI ... Uterine leiomyoma with right ovarian haemorrhagic luteum were histological diagnosed. ... Perivascular epithelioid cell tumor of the retroperitoneum in a young woman resulting in an abdominal chyloma. J Gastrointest ... Perivascular epithelioid cell tumor (PEComa) with perirenal manifestation. Int J Urol Off J Japanese Urol Assoc 12 (2005): 489- ...
Uterine leiomyoma HP:0000131 * epithelioid trophoblastic tumor DOID:3593 * endometriosis of uterus ...
Previously, these tumors were classified as GI leiomyomas, leiomyosarcomas, leiomyoblastomas, or schwannomas, on the basis of ... Epithelioid GISTs may have either a solid pattern or a myxoid pattern, with a possible compartmental pattern. Although GISTs ... 2] Only with tumors in the esophagus does the term leiomyoma remain accurate. Leiomyomas are the most common mesenchymal tumors ... Imaging in Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma. Updated: Nov 21, 2015 * Author: Vu H Nguyen, MD; Chief ...
Multiple epitheloid plexiform tumourlet leiomyoma of the uterus with focal vascular invasion. ... However, the prognosis of this variant of epithelioid leiomyoma remains unknown, due to its rarity. The main differential ... diagnosis of this entity are discussed, including endometrial stromal sarcoma exhibiting epitheloid cytomorphology, intravenous ... leiomyomatosis of epitheloid variant.. Asunto(s). Leiomioma Epitelioide/patología , Neoplasias Uterinas/patología , Adulto , ...
11.33).60 Epithelioid leiomyomas are very uncommon and are composed of large, epithelioid cells with abundant eosinophilic ... and epithelioid. Conventional leiomyomas appear similar to leiomyomas from other sites in the body and are circumscribed, ... Leiomyomas. Leiomyomas have been described throughout the upper aerodigestive tract but have been most frequently identified in ... Also, the fascicular cell arrangement of leiomyomas is much more pronounced, and the individual cells of those tumors are more ...
In the differential diagnosis of UTROSCT, we considered ESTSCLE, low-grade endometrial stromal sarcoma, epithelioid leiomyoma, ... The differential diagnosis of UTROSCT should consider epithelioid leiomyoma, ESTSCLE, endometrioid carcinoma with sex cord-like ...
From 27 leiomyomas, 21 (78%) were vascular type and only 6 (22%) were solid, no epithelioid was found. The table 1 shows ... Out of 102 leiomyomas, 71 (69,6%) were vascular, 28 (27,4%) solid and 3 (3%) epithelioid. Table 4 shows distribution of lesions ... Follow up data were reported for 53 cases with leiomyoma and 95 cases with leiomyosarcoma. Only 3 (6%) leiomyomas were reported ... The leiomyoma is more common in the fifth decade of life and the most affected sites are lips and tongue. The majority of cases ...
... malignant mixed mullerian tumors and highly cellular leiomyomas express CD10.[5,6] A perivascular epithelioid cell tumour ( ... Uterine leiomyoma are the commonest type of benign tumor of female reproductive tract during the reproductive age group with an ... Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review ... 2. Flake GP, Andersen J, Dixon D. Etiology and Pathogenesis of uterine leiomyomas: A review. Environ Health Perspect 2003; 111: ...
... epithelioid (clear cell) leiomyoma、endometrial stromal tumor 與 metastastic carcinoma。 ... 發生的年齡平均來說較良性的子宮肌瘤(leiomyoma)來得大些。由於其流行病學研究的結果與子宮內膜癌非常相近,其發生原因可能與雌激素有關。雖然都是源自於平滑肌的腫
Genital leiomyomas are histologically heterogeneous lesions that frequently contain cells with myxoid and epithelioid changes. ... Deep leiomyomas are less frequent than subcutaneous leiomyomas. Deep leiomyomas can occur in the deep parts of the extremities ... leiomyomas derived from the arrectores pilorum muscle complex and genital leiomyomas [19].. The arrectores pilorum leiomyomas ... 2. deep leiomyoma 8890/0. 3. genital leiomyoma 8890/0. B. Malignant tumors. Leiomyosarcoma ( excluding skin) 8890/3. Skeletal ...
If such a tumor does not stain for HMB-45 or Melan-A, a specific diagnosis of epithelioid pleomorphic angiomyolipoma cannot be ... We present here what is, to the best of our knowledge, the first case of epithelioid/pleomorphic angiomyolipoma of the kidney ... The tumor was composed of sheets of pleomorphic, round to polygonal epithelioid cells with prominent eosinophilic cytoplasm, ... we concluded this was a renal epithelioid/pleomorphic angiomyolipoma with a negative premelanosome antigen phenotype. ...
The cut surface resembles leiomyoma: firm, whorled or trabeculated, and pale (28). There is no true capsule. The tumor usually ... epithelioid, spindle cell, lymphomatoid, vascular, pseudopapillary, and cystic (39). These are usually mixed with the typical ...
Uterus and cervix were unremarkable grossly; however, the uterus showed an intramural leiomyoma. Bilateral ovaries and ... Guidelines for the cytopathologic diagnosis of epithelioid and mixed-type malignant mesothelioma. Complementary statement from ... epithelioid/polygonal cell (7 cases), and well-differentiated liposarcoma (1 case).21 In the spindle cell group, 7 cases were ... epithelioid-like cells forming acinar-like structures were also identified (Figure 1D). Mitoses were infrequent. The ...
Leiomyoma Page: Leiomyosarcoma Page: Leukemia Page: Lipoma Page: Liposarcoma Page: Low-grade intramedullary osteosarcoma Page: ... Epithelioid sarcoma Page: Fibromatosis Page: Fibrosarcoma Page: Fibrous cortical defect Page: Fibrous dysplasia Page: Ganglion ...
Uterine perivascular epithelioid cell tumour and assessment of its malignant potential. Wei Qiang Leow, Sathiyamoorthy ... A rare case of intratesticular leiomyoma. Zhan Peng Yong, Zhen Bang Liu, Cora Chau, Kian Tai Chong ...
  • These tumors are usually more than 5 cm in their greatest dimension, but a uterine mass of any size that has features different from the usual whorled, white, cut surface of a leiomyoma should be sampled. (medscape.com)
  • The three classically associated tumors are a subset of gastric epithelioid leiomyosarcoma (it is now known that this subset is actually gastrointestinal stromal tumor arising from the interstitial cells of Cajal), pulmonary chondroma, and extra-adrenal paraganglioma. (wikipedia.org)
  • In addition to these three classical tumors, there is an increased incidence of pheochromocytoma, esophageal leiomyoma and adrenocortical adenoma. (wikipedia.org)
  • Previously, these tumors were classified as GI leiomyomas, leiomyosarcomas, leiomyoblastomas, or schwannomas, on the basis of histologic findings and the fact that these tumors apparently originate in the muscularis propria layer of the intestinal wall. (medscape.com)
  • Morphologically, GISTs vary from cellular spindle cell tumors (70% - 80%) to epithelioid (20% - 30%) or mixed. (scirp.org)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)
  • Nine thousand seven hundred and seventy histopathologic exams were accomplished during this period and only 64 (0,092%) were diagnosed as smooth muscle tumors, that corresponded to 49 cases, being 27 (55%) leiomyomas e 22 (45%) leiomyossarcomas. (bvsalud.org)
  • In two fundamental papers based on lesions seen by the Armed Forces Institute of Pathology over a 10-years period, Kransdorf reported 311 benign tumors af muscular origin (leiomyomas) out of a total of 18.677 benign soft tissue tumors, or 1.7 % [ 32]. (5y1.org)
  • Most are spindle cell tumors as in this example, whereas others are epithelioid -- hwile others have a mixture of both morphologies. (surgpath4u.com)
  • Those tumors with PDGFRA mutations show a predilection for gastric GISTs with epithelioid morphology. (surgpath4u.com)
  • Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. (jogcr.com)
  • Epithelioid smooth-muscle tumors of the uterus: a clinicopathologic study of 18 patients. (jogcr.com)
  • The original description employed the then-prevailing terminology of gastric epithelioid leiomyosarcoma. (wikipedia.org)
  • The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. (wikipedia.org)
  • The aim of this study is to analyse and compare the clinical features of leiomyoma and leiomyosarcoma, because they help in the differential diagnosis. (bvsalud.org)
  • The histologic distinction between atypical leiomyoma and low grade leiomyosarcoma is difficult and is based on the following criteria: number of mitosis, cellular atypia and pattern of necrosis 5,6 . (bvsalud.org)
  • The aim of this retrospective study is to evaluate and compare clinical features, like gender, age, location and symptomatology of leiomyoma and leiomyosarcoma, and review the literature from 1970 to 2010, since there isn't any recent comparative article. (bvsalud.org)
  • Records of oral leiomyoma and leiomyosarcoma from Oral Pathology Department of Dental School at University of São Paulo during the period 1962-2010 were analysed. (bvsalud.org)
  • The primary differential medical diagnosis of GIST contains simple muscles tumours (leiomyoma and leiomyosarcoma), nerve sheath tumours (schwannoma and neurofibroma), inflammatory fibroid polyp and desmoid fibromatosis. (moonphase2018.com)
  • Gastric gastrointestinal stromal tumor (GIST) en face. (medscape.com)
  • Case Report: We reported a case of 55-year-old post menopausal woman who presented to us as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
  • Our case was also presented as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
  • Histopathology report showed the retroperitoneal mass to be a malignant epithelioid gastrointestinal tumor. (scirp.org)
  • If such a tumor does not stain for HMB-45 or Melan-A, a specific diagnosis of epithelioid pleomorphic angiomyolipoma cannot be made with certainty. (biomedcentral.com)
  • We present here what is, to the best of our knowledge, the first case of epithelioid/pleomorphic angiomyolipoma of the kidney in a 50-year-old Caucasian man with no history of tuberous sclerosis, and with a tumor marker profile negative for several premelanosome antigens. (biomedcentral.com)
  • The tumor was composed of sheets of pleomorphic, round to polygonal epithelioid cells with prominent eosinophilic cytoplasm, large nuclei, many multinucleated, and very prominent nucleoli. (biomedcentral.com)
  • Based on the characteristic microscopic appearance of this tumor, and its overall tumor marker profile, we concluded this was a renal epithelioid/pleomorphic angiomyolipoma with a negative premelanosome antigen phenotype. (biomedcentral.com)
  • Uterine leiomyoma must be differentiated from other diseases that cause uterine mass, such as: uterine adenomyoma , pregnancy , hematometra , uterine sarcoma , uterine carcinosarcoma, and metastasis . (wikidoc.org)
  • The main differential diagnosis of this entity are discussed, including endometrial stromal sarcoma exhibiting epitheloid cytomorphology, intravenous leiomyomatosis of epitheloid variant. (bvsalud.org)
  • In the differential diagnosis of UTROSCT, we considered ESTSCLE, low-grade endometrial stromal sarcoma, epithelioid leiomyoma, and endometrioid carcinoma with sex-cord-like elements. (turkjpath.org)
  • Common risk factors in the development of uterine leiomyoma include African-American race, early menarche , prenatal exposure to diethylstilbestrol , having one or more pregnancies extending beyond 20 weeks, obesity , significant consumption of beef and other red meats, hypertension , family history , and alcohol consumption. (wikidoc.org)
  • The mainstay of therapy for uterine leiomyoma is oral contraceptive pills , either combination pills or progestin-only , Gonadotropin-releasing hormone analogs . (wikidoc.org)
  • Surgery is also part of mainstay therapy for uterine leiomyoma. (wikidoc.org)
  • However, of a uterine leiomyoma with other genital blood tests on the woman were normal and organs unaffected. (who.int)
  • Cytologically, GISTs can be classified into 2 broad categories: spindle cell GISTs and epithelioid GISTs. (medscape.com)
  • Epithelioid GISTs may have either a solid pattern or a myxoid pattern, with a possible compartmental pattern. (medscape.com)
  • After Imatinib therapy, some GISTs as well as exhibit a more epithelioid morphology as seen here -- loss of c-KIT and CD34 immunopositivity have been described as well (Fletcher). (surgpath4u.com)
  • Because GISTs often looked like swirling fascicles of smooth muscle cells under the microscope, they were historically classified as leiomyomas or leiomyosarcomas. (surgpath4u.com)
  • GISTs are cytologically monomorphic and display spindle cell or epithelioid cell cytomorphology generally, and a blended pattern comprising both epithelioid and spindle cells [10]. (moonphase2018.com)
  • Epithelioid and blended epithelioid and spindle GISTs are more prevalent in the tummy [16]. (moonphase2018.com)
  • Spindle cell GISTs are organized in fascicles, and epithelioid tumours are arranged in nests or bed sheets often. (moonphase2018.com)
  • 1) pure spindled cell (most GISTs), (2) mixed-spindled and epithelioid, (3) pure epithelioid cells (usually only seen in the stomach). (cap.org)
  • Histologically, not absolutely all GISTs are comprised of spindle cells, which makes up about just 70% of GISTs, and various other subtypes such as for example epithelioid cells and blended spindle and epithelioid cells take into account 20% and 10% of GISTs. (mycareerpeer.com)
  • In addition, the mimics of GISTs, such as leiomyomas, leiomyosarcomas and schwannomas, were near-universally bad for CD117, indicating that CD117 is definitely a highly sensitive and specific marker for GISTs [9,10,20]. (mycareerpeer.com)
  • Microscopically, the benign leio- multiple calcified bilharzial ova myoma showed multiple epitheloid granu- lomas with calcified bilharzial ova within the leiomyoma. (who.int)
  • The rare variant of renal epithelioid/pleomorphic angiomyolipoma has been reported in approximately 120 cases. (biomedcentral.com)
  • Rare cases of AML, composed of a prominent epithelioid component, with spindle and giant cells, containing none or a minimal amount of adipose tissue, have been reported as the epithelioid variant of angiomyolipoma (EAML) [ 2 ]. (biomedcentral.com)
  • In appearance, leiomyosarcomas of the uterus have features that range from those similar to leiomyoma (rare) to overtly malignant, gross features similar to those of high-grade sarcomas that may occur anywhere in the body, with infiltrative edges, necrosis, hemorrhage, and a variegated cut surface. (medscape.com)
  • Atypical leiomyoma of the uterus: a clinicopathologic study of 46 cases [abstract]. (jogcr.com)
  • Bizarre leiomyomas of the uterus: a comprehensive pathologic study of 24 cases with long-term follow-up. (jogcr.com)
  • Leiomyomas can start almost anywhere in the body but are most common in the gastrointestinal (GI) tract and uterus. (cancer.ca)
  • A leiomyoma that develops in the uterus is also called a fibroid. (cancer.ca)
  • Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases. (uchicago.edu)
  • The Carney complex is a distinct entity, characterized by myxomatous neoplasms (cardiac, endocrine, cutaneous and neural), and a host of pigmented lesions of the skin and mucosae, including the rarely occurring epitheloid blue nevus. (wikipedia.org)
  • The epithelioid cells in EAML can be quite pleomorphic and the appearance of a carcinoma-like pattern is frequently observed. (biomedcentral.com)
  • Background: Perivascular epithelioid cell tumours (PEComas) are mesenchymal neoplasms with variable biological behaviour, ranging from benign to extremely aggressive diseases able to metastasize. (fortuneonline.org)
  • Leiomyomas are non-cancerous tumours that develop in smooth muscle. (cancer.ca)
  • Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients. (uchicago.edu)
  • they range from benign leiomyomas to low-grade and high-grade leiomyosarcomas . (medscape.com)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • RESULTS: The leiomyoma showed bizarre histologic appearance in absence of mitotic figures and degenerative changes. (lookfordiagnosis.com)
  • Conclusion: Le cancer de l'endomètre étant un cancer souvent d'emblée de mauvais pronostic, il est d'intérêt de mettre en place une stratégie de prévention et de management adapté.Mots clés: cancer, endomètre, étude clinicopathologique, suivi, Gabon Abstract:Introduction:The general objective of our work was to provide an epidemiological and clinicopathological description of endometrial cancer in Gabon. (bvsalud.org)
  • Angioleiomyoma, angiomyoma or vascular leiomyomas are histologically divided into three subtypes: solid, cavernous and venous. (5y1.org)
  • Figure 2 An epithelioid granuloma with section. (who.int)
  • The resultant granulomatous inflammation had possibly influenced the Figure 1 An epithelioid granuloma within the size of the fibroid, explaining its relatively leiomyoma large size in this patient. (who.int)
  • These leiomyomas present as solitary or multiple painful nodules with a diameter of 1-2 cm. (5y1.org)
  • However, the prognosis of this variant of epithelioid leiomyoma remains unknown, due to its rarity. (bvsalud.org)
  • Epithelioid cells are associated with more aggressive behavior and carry a poorer prognosis for the patient's survival. (medscape.com)
  • GIST can also show an epithelioid appearance , with distinct polygonal cells with a moderate amount of cytoplasm. (surgpath4u.com)
  • Superficial or cutaneous leiomyomas must be divided into two entities: leiomyomas derived from the arrectores pilorum muscle complex and genital leiomyomas [19]. (5y1.org)
  • Submucosal leiomyomas occur within the myometrium. (medscape.com)
  • Clinical-pathological study of uterine leiomyomas with high mitotic activity. (jogcr.com)
  • When they degenerate, leiomyomata may assume a red discoloration, called carneous degeneration (the nodule looks like skeletal muscle). (medscape.com)
  • Leiomyomas are often responsive to hormones. (medscape.com)
  • CONCLUSION: Progestin as part of a combined hormonal replacement therapy may play an important role in promoting the development of leiomyoma in hormonal responsive tissue of the round ligament in postmenopausal women . (lookfordiagnosis.com)
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
  • On gross pathology , round, well circumscribed, non-encapsulated, solid white or tan nodules , and whorled are characteristic findings of leiomyoma. (wikidoc.org)
  • The leiomyoma/myometrial interface is smooth and very well circumscribed (see the image below). (medscape.com)
  • They usually do not exhibit the whirling smooth muscle pattern of leiomyomas. (surgpath4u.com)
  • More aggressive iris melanomas (Fig. 2B) exhibit a varying amount of epithelioid cells. (aao.org)
  • exhibit an epithelioid morphology, 2. (surgpath4u.com)
  • There are rare AMLs of epithelioid type that can exhibit malignant behavior. (pediagenosis.com)
  • Three distinct cell types are recognized in uveal melanomas: spindle A, spindle B, and epithelioid. (medscape.com)
  • Leiomyomas are more frequent in Black women. (medscape.com)
  • Leiomyoma was more frequent in the fifth decade of life. (bvsalud.org)