A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
Tumors or cancer of the UTERUS.
A tumor composed of smooth muscle tissue, as opposed to leiomyoma, a tumor derived from smooth muscle.
A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
Tumor or cancer of the MALE GENITALIA.
Retroperitoneal neoplasms are a diverse group of tumors that originate in the retroperitoneal space, which is the area behind the peritoneum and includes the kidneys, adrenal glands, pancreas, and major blood vessels.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Either of a pair of tubular structures formed by DUCTUS DEFERENS; ARTERIES; VEINS; LYMPHATIC VESSELS; and nerves. The spermatic cord extends from the deep inguinal ring through the INGUINAL CANAL to the TESTIS in the SCROTUM.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Short thick veins which return blood from the kidneys to the vena cava.
A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
Neoplasms of the bony part of the skull.
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.

Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma. (1/527)

Distinction of malignant uterine leiomyosarcomas from benign leiomyomas by morphological criteria is not always possible. Leiomyosarcomas typically have complex cytogenetic abnormalities; in contrast, leiomyomas have simple or no cytogenetic abnormalities. To understand better the biological distinction(s) between these tumors, we analyzed two other potential markers of genomic instability, loss of heterozygosity (LOH) and microsatellite instability. We examined archival materials from 16 leiomyosarcomas and 13 benign leiomyomas by polymerase chain reaction for 26 microsatellite polymorphisms. Markers were selected based on previous reports of cytogenetic or molecular genetic abnormalities in leiomyosarcomas or leiomyomas and surveyed chromosomes 7, 9, 10, 11, 12, 14, 15, 16, 18, 21, and X. LOH for markers on chromosomes 15, 18, 21, and X was infrequent in leiomyosarcomas (1 of 6 tumors for each chromosome) and not observed for markers on chromosomes 7, 9, 11, 12, 14, or 16. Interestingly, 8 of 14 (57.2%) informative leiomyosarcomas had LOH for at least one marker on chromosome 10 and involved both chromosomal arms in 45.5% (5 of 11). In contrast to leiomyosarcomas, LOH for chromosome 10 was not found in 13 benign leiomyomas. Microsatellite instability was found infrequently in leiomyosarcomas and not detected in leiomyoma. Clinicopathological features (eg, atypia, necrosis, and clinical outcome) did not appear to correlate with LOH for chromosome 10. In contrast to other chromosomes studied, LOH on chromosome 10 was frequent in leiomyosarcomas and absent in benign leiomyomas.  (+info)

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice. (2/527)

To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridization revealed that the transgene is stably maintained in all organs of transgenic mice as a tandem insertion in a number of copies ranging from 5 to 20 per cell. In addition, tat and BKV RNA were expressed in all tissues. Transgenic mice developed three types of lesions: 1) tumors, 2) hyperplastic and dysplastic lesions, and 3) non-neoplastic lesions. Tumors of different histotypes, such as lymphomas, adenocarcinomas of skin glands, leiomyosarcomas, skin squamous cell carcinomas, hepatomas, hepatocarcinomas, and cavernous liver hemangiomas, developed in 29% of transgenic animals. The majority of tumors were malignant, invasive, and producing metastases. Conversely, tumors of only two histotypes (lymphomas and adenocarcinomas of skin glands) appeared in control mice. Hyperplastic and dysplastic lesions were more frequent in transgenic than in control mice and involved the skin or its adnexes, the liver and the rectum, indicating multiple targets for the activity of the transgene. Pyelonephritis, frequently complicated with hydronephrosis, inflammatory eye lesions, and amyloid depositions represented the most frequent non-neoplastic lesions detected in transgenic mice. Many of the pathological findings observed in this animal model are comparable to similar lesions appearing in AIDS patients, suggesting a relevant role for Tat in the pathogenesis of such lesions during the course of AIDS.  (+info)

Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. (3/527)

BACKGROUND: Calponin h1, a basic actin-binding protein capable of inhibiting smooth muscle contraction, is a constitutive element of smooth muscle cells. However, in leiomyosarcoma (a type of smooth muscle neoplasm of the uterus), reduced expression of calponin h1 is observed, as we have reported previously. In this study, we sought to assess the effects (in vitro and in vivo) of increasing calponin h1 expression in leiomyosarcoma cells. METHODS: A plasmid containing a human calponin h1 complementary DNA and a bacterial neomycin-resistance gene was transfected into the human leiomyosarcoma cell lines SKN and SK-LMS-1 by electroporation. Southern blotting, reverse transcription-polymerase chain reaction analysis, western blotting, and immunohistochemistry were used to confirm DNA transfer and expression of the calponin h1 protein in neomycin-resistant clones. We characterized the morphology of calponin h1-transfected cells, and we evaluated their proliferative activity and tumorigenicity by use of a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, an anchorage-independent growth assay, and a nude mouse tumorigenicity assay. RESULTS: The morphology of calponin h1-transfected cells in culture resembled that of cultured normal myometrial smooth muscle cells. With SK-LMS-1 cells, proliferation of calponin h1-transfection cells was reduced to 69% of control; with SKN cells, calponin h1 transfection reduced proliferation to 70% of control. In assays of anchorage-independent growth and in vivo tumorigenicity, both growth and tumorigenicity were statistically significantly reduced in calponin h1-transfected leiomyosarcoma cells. CONCLUSIONS: Calponin h1 may function as a tumor suppressor in leiomyosarcoma. Clinically, transfer of a calponin h1 complementary DNA into poorly differentiated leiomyosarcoma cells may be of potential therapeutic value through induction of a normal, differentiated cellular phenotype.  (+info)

Cerebral metastasis of a uterine leiomyosarcoma--case report. (4/527)

A 38-year-old female presented with sudden neurological deterioration 6 years after an operation and chemotherapy for uterine leiomyosarcoma. An extremely rare metastasis of the uterine leiomyosarcoma to the brain was identified and totally resected. Whole brain irradiation (50 Gy) was given. A recurrence of the metastasis was resected 10 weeks later. She ultimately died of a second recurrence. Aggressive surgical management of cerebral metastasis of uterine leiomyosarcoma may achieve an improved outcome.  (+info)

Leiomyosarcoma of the esophagus in a patient with chagasic megaesophagus: case report and literature review. (5/527)

Leiomyosarcoma constitutes approximately 0.5% of the malignant neoplasias of the esophagus and its association with megaesophagus has not been described. We report on a case of a woman with dysphagia that was slowly progressive from the age of 19 due to chagasic megaesophagus. The woman was subjected to cardiomyotomy at the age of 49. She presented a rapid worsening of the dysphagia due to leiomyosarcoma at the age of 61, and was subjected to subtotal esophagectomy with cervical esophagogastroplasty. She developed pulmonary and hepatic metastases 14 months after surgery and died six months later.  (+info)

"Mesenchymal tumor" or "decidual-like reaction"? (6/527)

For more than 40 yr, an unusual urinary bladder lesion has been known to occur in certain strains of mice, but no consensus has been obtained regarding its etiology, pathogenesis, biology, or classification. The lesion was first assumed to be epithelial and non-neoplastic, then it was called a smooth muscle cell tumor or leiomyosarcoma because of ultrastructural characteristics for smooth muscle cells. Later, the nonspecific term "mesenchymal tumor" was introduced due to histomorphologic differences from all smooth muscle tumors known. Recently, a proposal was made to name it "decidual-like reaction" because of the histomorphologic similarity to the rare spontaneous decidual reaction in the uterus of aging mice. Both lesions are characterized by spindle and large pleomorphic epithelioid cells with large bizarre nuclei; these characteristics mimic anaplasia of malignant tumors and led pathologists to assume a neoplastic nature. The decidual hypothesis is supported by the regular presence of nuclear progesterone receptors, the occasional occurrence of eosinophilic cytoplasmic granules, the rare finding of cells morphologically resembling granulated metrial gland cells (all also observed in the uterine decidual reaction), and the reproducibility through long-term feeding of combinations of estrogens and progestogens. It appears that the new decidual hypothesis can explain many detailed facets of the lesion, with the exception of the reported smooth muscle cell characteristics. The controversy of "mesenchymal tumor versus decidual-like reaction" should be resolved soon, not only as a scientific issue, but also because of consequences for risk assessment.  (+info)

Correlation between clinicopathological features and karyotype in spindle cell sarcomas. A report of 130 cases from the CHAMP study group. (7/527)

Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far, however, data regarding sarcomas of monomorphic spindle cell type have been limited and somewhat disappointing, with the notable exception of synovial sarcoma. As part of an ongoing international collaborative study, 130 karyotyped spindle-cell sarcomas were reviewed and classified histologically, without knowledge of the clinical and karyotypic data, with the aim of identifying objective correlations between morphology, karyotype, and clinical parameters. Clonal chromosomal abnormalities were identified in 82 cases studied (63%), but only in the group of synovial sarcomas was there clear correlation between the cytogenetic findings, in the form of a consistent t(X;18)(p11;q11), and morphology. Among leiomyosarcomas (41 cases) and malignant peripheral nerve sheath tumors (MPNSTs; 27 cases) as well as in individual examples of rarer entities, there was a general tendency for karyotypic complexity associated with frequent loss or rearrangement of chromosome arms 1p, 10p, 11q, 12q, 17p, and 22q. Rearrangements of 17q (the region of the NF1 gene) were seen in 9/27 (33%) of MPNSTs. Among nine cases of solitary fibrous tumor (in which previous cytogenetic data are very limited) no consistent aberrations were identified. We conclude that, with the exception of synovial sarcoma, most spindle-cell sarcomas share with pleomorphic sarcomas the tendency for karyotypic complexity. There was no indication (in most of these lesions) that detectable cytogenetic aberrations could either facilitate their diagnosis or help to determine prognosis. There is a clear need to further study and understand the significance of multiple chromosomal abnormalities in this group of mesenchymal neoplasms with the particular goal of determining their role in the process of tumor development.  (+info)

Prognostic significance of bcl-2 expression in leiomyosarcoma of the uterus. (8/527)

We examined bcl-2 expression as well as p53 expression and mutation in human uterine smooth muscle tumours to determine the influence of bcl-2 expression on prognosis in patients with uterine leiomyosarcomas. bcl-2 protein was expressed in nearly all benign smooth muscle tumours but in only 57% of leiomyosarcomas. Benign smooth muscle tumours were usually negative for p53 protein, but 16 out of 21 (76%) leiomyosarcomas were positive. A p53 gene mutation was detected in nine of the 16 leiomyosarcomas that showed p53-positive staining. A significant positive correlation was observed between p53 mutation and p53 expression, between the number of mitoses and the Ki-67 labelling index, and between clinical stage and p53 mutation. A significant negative correlation was observed between bcl-2 expression and p53 mutation, and between bcl-2 expression and p53 overexpression. Univariate survival analysis revealed that bcl-2 expression, p53 mutation and clinical stage (stage 1 vs stages 2-4) all showed a significant correlation with prognosis. In a multivariate stepwise regression analysis, positive bcl-2 expression and stage 1 disease were the independent predictors of a favourable prognosis. Our results suggest that bcl-2 is frequently expressed in human uterine smooth muscle tumours, and that its expression may correlate with a favourable prognosis in patients with uterine leiomyosarcoma.  (+info)

Leiomyosarcoma is a type of cancer that arises from the smooth muscle cells, which are responsible for the involuntary contractions of various organs and blood vessels. It most commonly occurs in the uterus, soft tissues (such as muscles and fat), and the gastrointestinal tract.

Leiomyosarcomas can vary in their aggressiveness and may spread to other parts of the body (metastasize) through the bloodstream or lymphatic system. The prognosis for leiomyosarcoma depends on several factors, including the location and size of the tumor, the patient's age and overall health, and the extent of metastasis. Treatment typically involves surgical removal of the tumor, along with radiation therapy and/or chemotherapy to help prevent recurrence or spread of the cancer.

Vascular neoplasms are a type of tumor that develops from cells that line the blood vessels or lymphatic vessels. These tumors can be benign (non-cancerous) or malignant (cancerous). Benign vascular neoplasms, such as hemangiomas and lymphangiomas, are usually harmless and may not require treatment unless they cause symptoms or complications. Malignant vascular neoplasms, on the other hand, are known as angiosarcomas and can be aggressive, spreading to other parts of the body and potentially causing serious health problems.

Angiosarcomas can develop in any part of the body but are most commonly found in the skin, particularly in areas exposed to radiation or chronic lymph edema. They can also occur in the breast, liver, spleen, and heart. Treatment for vascular neoplasms depends on the type, location, size, and stage of the tumor, as well as the patient's overall health. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Uterine neoplasms refer to abnormal growths in the uterus, which can be benign (non-cancerous) or malignant (cancerous). These growths can originate from different types of cells within the uterus, leading to various types of uterine neoplasms. The two main categories of uterine neoplasms are endometrial neoplasms and uterine sarcomas.

Endometrial neoplasms develop from the endometrium, which is the inner lining of the uterus. Most endometrial neoplasms are classified as endometrioid adenocarcinomas, arising from glandular cells in the endometrium. Other types include serous carcinoma, clear cell carcinoma, and mucinous carcinoma.

Uterine sarcomas, on the other hand, are less common and originate from the connective tissue (stroma) or muscle (myometrium) of the uterus. Uterine sarcomas can be further divided into several subtypes, such as leiomyosarcoma, endometrial stromal sarcoma, and undifferentiated uterine sarcoma.

Uterine neoplasms can cause various symptoms, including abnormal vaginal bleeding or discharge, pelvic pain, and difficulty urinating or having bowel movements. The diagnosis typically involves a combination of imaging tests (such as ultrasound, CT, or MRI scans) and tissue biopsies to determine the type and extent of the neoplasm. Treatment options depend on the type, stage, and patient's overall health but may include surgery, radiation therapy, chemotherapy, or hormone therapy.

A smooth muscle tumor refers to a growth that develops in the smooth muscles, which are involuntary muscles found in various organs and structures throughout the body, including the digestive tract, uterus, blood vessels, and bladder. These tumors can be benign (noncancerous) or malignant (cancerous).

Benign smooth muscle tumors are called leiomyomas. They are typically slow-growing and rarely spread to other parts of the body. Leiomyomas are often asymptomatic but can cause problems depending on their location. For instance, a leiomyoma in the uterus might lead to heavy menstrual periods or difficulty becoming pregnant.

Malignant smooth muscle tumors are called leiomyosarcomas. These tumors are more aggressive and have a higher risk of spreading to other parts of the body. Symptoms can vary widely depending on the location of the tumor but may include abdominal pain, bloating, or bleeding.

It's important to note that while some smooth muscle tumors can be removed surgically, others may require additional treatment such as radiation therapy or chemotherapy, especially in cases of leiomyosarcomas. Regular follow-up with a healthcare provider is essential to monitor for recurrence and manage any potential complications.

Leiomyoma is a benign (non-cancerous) tumor that originates from the smooth muscle cells. It most commonly occurs in the uterus, where it is also known as a fibroid, but can also develop in other parts of the body such as the skin, gastrointestinal tract, and genitourinary system. Leiomyomas are typically slow-growing and often cause no symptoms, although they can lead to various complications depending on their size and location. Treatment options for leiomyomas include surveillance, medication, or surgical removal.

Soft tissue neoplasms refer to abnormal growths or tumors that develop in the soft tissues of the body. Soft tissues include muscles, tendons, ligaments, fascia, nerves, blood vessels, fat, and synovial membranes (the thin layer of cells that line joints and tendons). Neoplasms can be benign (non-cancerous) or malignant (cancerous), and their behavior and potential for spread depend on the specific type of neoplasm.

Benign soft tissue neoplasms are typically slow-growing, well-circumscribed, and rarely spread to other parts of the body. They can often be removed surgically with a low risk of recurrence. Examples of benign soft tissue neoplasms include lipomas (fat tumors), schwannomas (nerve sheath tumors), and hemangiomas (blood vessel tumors).

Malignant soft tissue neoplasms, on the other hand, can grow rapidly, invade surrounding tissues, and may metastasize (spread) to distant parts of the body. They are often more difficult to treat than benign neoplasms and require a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy. Examples of malignant soft tissue neoplasms include sarcomas, such as rhabdomyosarcoma (arising from skeletal muscle), leiomyosarcoma (arising from smooth muscle), and angiosarcoma (arising from blood vessels).

It is important to note that soft tissue neoplasms can occur in any part of the body, and their diagnosis and treatment require a thorough evaluation by a healthcare professional with expertise in this area.

Sarcoma is a type of cancer that develops from certain types of connective tissue (such as muscle, fat, fibrous tissue, blood vessels, or nerves) found throughout the body. It can occur in any part of the body, but it most commonly occurs in the arms, legs, chest, and abdomen.

Sarcomas are classified into two main groups: bone sarcomas and soft tissue sarcomas. Bone sarcomas develop in the bones, while soft tissue sarcomas develop in the soft tissues of the body, such as muscles, tendons, ligaments, fat, blood vessels, and nerves.

Sarcomas can be further classified into many subtypes based on their specific characteristics, such as the type of tissue they originate from, their genetic makeup, and their appearance under a microscope. The different subtypes of sarcoma have varying symptoms, prognoses, and treatment options.

Overall, sarcomas are relatively rare cancers, accounting for less than 1% of all cancer diagnoses in the United States each year. However, they can be aggressive and may require intensive treatment, such as surgery, radiation therapy, and chemotherapy.

The inferior vena cava (IVC) is the largest vein in the human body that carries deoxygenated blood from the lower extremities, pelvis, and abdomen to the right atrium of the heart. It is formed by the union of the left and right common iliac veins at the level of the fifth lumbar vertebra. The inferior vena cava is a retroperitoneal structure, meaning it lies behind the peritoneum, the lining that covers the abdominal cavity. It ascends through the posterior abdominal wall and passes through the central tendon of the diaphragm to enter the thoracic cavity.

The inferior vena cava is composed of three parts:

1. The infrarenal portion, which lies below the renal veins
2. The renal portion, which receives blood from the renal veins
3. The suprahepatic portion, which lies above the liver and receives blood from the hepatic veins before draining into the right atrium of the heart.

The inferior vena cava plays a crucial role in maintaining venous return to the heart and contributing to cardiovascular function.

Genital neoplasms in males refer to abnormal growths or tumors that develop in the male reproductive organs. These can be benign (non-cancerous) or malignant (cancerous).

Malignant genital neoplasms are often referred to as genital cancers. The most common types of male genital cancers include:

1. Penile Cancer: This occurs when cancer cells form in the tissues of the penis.
2. Testicular Cancer: This forms in the testicles (testes), which are located inside the scrotum.
3. Prostate Cancer: This is a common cancer in men, forming in the prostate gland, which is part of the male reproductive system that helps make semen.
4. Scrotal Cancer: This is a rare form of cancer that forms in the skin or tissue of the scrotum.
5. Penile Intraepithelial Neoplasia (PeIN): This is not cancer, but it is considered a pre-cancerous condition of the penis.

Early detection and treatment of genital neoplasms can significantly improve the prognosis. Regular self-examinations and medical check-ups are recommended, especially for individuals with risk factors such as smoking, HIV infection, or a family history of these cancers.

Retroperitoneal neoplasms refer to abnormal growths or tumors that develop in the retroperitoneal space. This is the area located behind the peritoneum, which is the membrane that lines the abdominal cavity and covers the abdominal organs. The retroperitoneal space contains several vital structures such as the kidneys, adrenal glands, pancreas, aorta, and lymphatic vessels.

Retroperitoneal neoplasms can be benign or malignant (cancerous). Malignant retroperitoneal neoplasms are often aggressive and can invade surrounding tissues and organs, leading to various complications. Common types of retroperitoneal neoplasms include lymphomas, sarcomas, and metastatic tumors from other primary sites. Symptoms may vary depending on the size and location of the tumor but can include abdominal or back pain, weight loss, and swelling in the legs. Diagnosis typically involves imaging studies such as CT scans or MRI, followed by a biopsy to determine the type and grade of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Muscle neoplasms are abnormal growths or tumors that develop in the muscle tissue. They can be benign (non-cancerous) or malignant (cancerous). Benign muscle neoplasms are typically slow-growing and do not spread to other parts of the body, while malignant muscle neoplasms, also known as soft tissue sarcomas, can grow quickly, invade nearby tissues, and metastasize (spread) to distant parts of the body.

Soft tissue sarcomas can arise from any of the muscles in the body, including the skeletal muscles (voluntary muscles that attach to bones and help with movement), smooth muscles (involuntary muscles found in the walls of blood vessels, digestive tract, and other organs), or cardiac muscle (the specialized muscle found in the heart).

There are many different types of soft tissue sarcomas, each with its own set of characteristics and prognosis. Treatment for muscle neoplasms typically involves a combination of surgery, radiation therapy, and chemotherapy, depending on the type, size, location, and stage of the tumor.

Heart neoplasms are abnormal growths or tumors that develop within the heart tissue. They can be benign (noncancerous) or malignant (cancerous). Benign tumors, such as myxomas and rhabdomyomas, are typically slower growing and less likely to spread, but they can still cause serious complications if they obstruct blood flow or damage heart valves. Malignant tumors, such as angiosarcomas and rhabdomyosarcomas, are fast-growing and have a higher risk of spreading to other parts of the body. Symptoms of heart neoplasms can include shortness of breath, chest pain, fatigue, and irregular heart rhythms. Treatment options depend on the type, size, and location of the tumor, and may include surgery, radiation therapy, or chemotherapy.

Mesenchymoma is a very rare type of tumor that contains a mixture of different types of mesenchymal tissues, such as muscle, fat, bone, cartilage, or fibrous tissue. It typically occurs in children and young adults, and can be found in various parts of the body, including the head, neck, retroperitoneum (the area behind the abdominal cavity), and the limbs.

Mesenchymomas are usually slow-growing and may not cause any symptoms until they reach a large size. Treatment typically involves surgical removal of the tumor, but radiation therapy or chemotherapy may also be used in some cases. The prognosis for mesenchymoma depends on several factors, including the location and size of the tumor, the patient's age and overall health, and the specific types of tissue that are present in the tumor.

The spermatic cord is a fibrous structure that contains the vas deferens, blood vessels, nerves, and lymphatics, which provide passage for these structures between the abdomen and the scrotum in males. It is covered by several layers of protective sheaths, including the internal spermatic fascia, cremasteric fascia, and external spermatic fascia. The spermatic cord allows the testicles to be located outside the body, which helps maintain a cooler temperature for optimal sperm production.

A neoplasm of vascular tissue is an abnormal growth or mass of cells in the blood vessels or lymphatic vessels. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms, such as hemangiomas and lymphangiomas, are typically not harmful and may not require treatment. However, they can cause symptoms if they grow large enough to press on nearby organs or tissues. Malignant neoplasms, such as angiosarcomas, are cancerous and can invade and destroy surrounding tissue, as well as spread (metastasize) to other parts of the body. Treatment for vascular tissue neoplasms depends on the type, size, location, and stage of the growth, and may include surgery, radiation therapy, chemotherapy, or a combination of these.

The renal veins are a pair of large veins that carry oxygen-depleted blood and waste products from the kidneys to the inferior vena cava, which is the largest vein in the body that returns blood to the heart. The renal veins are formed by the union of several smaller veins that drain blood from different parts of the kidney.

In humans, the right renal vein is shorter and passes directly into the inferior vena cava, while the left renal vein is longer and passes in front of the aorta before entering the inferior vena cava. The left renal vein also receives blood from the gonadal (testicular or ovarian) veins, suprarenal (adrenal) veins, and the lumbar veins.

It is important to note that the renal veins are vulnerable to compression by surrounding structures, such as the overlying artery or a tumor, which can lead to renal vein thrombosis, a serious condition that requires prompt medical attention.

Liposarcoma is a type of soft tissue sarcoma, which is a cancer that develops in the soft tissues of the body, such as fat, muscle, nerves, blood vessels, and fibrous tissues. Specifically, liposarcoma arises from fat cells (adipocytes) or their precursors.

There are several subtypes of liposarcoma, which differ in their appearance under the microscope, genetic features, and clinical behavior. These include well-differentiated, dedifferentiated, myxoid, round cell, and pleomorphic liposarcomas. The most common sites for liposarcoma are the thigh, retroperitoneum (the area behind the abdominal cavity), and the buttock.

Liposarcomas can grow slowly or rapidly, and they may spread to other parts of the body (metastasize) through the bloodstream or lymphatic system. Treatment typically involves surgical removal of the tumor, often followed by radiation therapy and/or chemotherapy. The prognosis for liposarcoma depends on several factors, including the type and grade of the tumor, its size and location, and whether it has spread to other parts of the body.

Skull neoplasms refer to abnormal growths or tumors that develop within the skull. These growths can be benign (non-cancerous) or malignant (cancerous). They can originate from various types of cells, such as bone cells, nerve cells, or soft tissues. Skull neoplasms can cause various symptoms depending on their size and location, including headaches, seizures, vision problems, hearing loss, and neurological deficits. Treatment options include surgery, radiation therapy, and chemotherapy. It is important to note that a neoplasm in the skull can also refer to metastatic cancer, which has spread from another part of the body to the skull.

Jejunal neoplasms refer to abnormal growths or tumors in the jejunum, which is the middle section of the small intestine. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Malignant jejunal neoplasms are often aggressive and can spread to other parts of the body, making them potentially life-threatening.

There are several types of jejunal neoplasms, including:

1. Adenocarcinomas: These are cancerous tumors that develop from the glandular cells lining the jejunum. They are the most common type of jejunal neoplasm.
2. Carcinoid tumors: These are slow-growing neuroendocrine tumors that arise from the hormone-producing cells in the jejunum. While they are usually benign, some can become malignant and spread to other parts of the body.
3. Gastrointestinal stromal tumors (GISTs): These are rare tumors that develop from the connective tissue cells in the jejunum. They can be benign or malignant.
4. Lymphomas: These are cancerous tumors that develop from the immune system cells in the jejunum. They are less common than adenocarcinomas but can be aggressive and spread to other parts of the body.
5. Sarcomas: These are rare cancerous tumors that develop from the connective tissue cells in the jejunum. They can be aggressive and spread to other parts of the body.

Symptoms of jejunal neoplasms may include abdominal pain, bloating, diarrhea, weight loss, and bleeding in the stool. Treatment options depend on the type and stage of the neoplasm but may include surgery, chemotherapy, radiation therapy, or a combination of these approaches.

Malignant fibrous histiocytoma (MFH) is not a specific type of histiocytoma; rather, it is a type of soft tissue sarcoma. Histiocytomas are benign tumors that arise from cells called histiocytes, which are part of the immune system. MFH, on the other hand, is a malignant (cancerous) tumor that can arise in various types of soft tissues, such as muscle, fat, tendons, and ligaments.

MFH was once thought to originate from histiocytes, but more recent research suggests that it may actually arise from undifferentiated mesenchymal cells, which are capable of developing into a variety of different cell types. MFH is the most common type of soft tissue sarcoma in adults over the age of 50 and typically presents as a painless mass in the extremities or retroperitoneum (the area in the back of the abdomen).

The tumor is characterized by the presence of fibroblastic and histiocytic-like cells, which can be quite pleomorphic (varied in shape and size) and may contain numerous mitotic figures (indicating rapid cell division). Treatment typically involves surgical excision, often followed by radiation therapy and/or chemotherapy. The prognosis for MFH depends on several factors, including the tumor's location, size, grade (degree of differentiation), and the patient's age and overall health.

Uterine leiomyosarcomas come from the smooth muscle in the muscle layer of the uterus. Cutaneous leiomyosarcomas derive from ... "Leiomyosarcoma - NCI". www.cancer.gov. 2020-06-22. Retrieved 2023-10-04. "Basic info". Leiomyosarcoma.info. Archived from the ... leiomyosarcomas appear to grow from the muscle layer of a blood vessel (the tunica media). Thus, a leiomyosarcoma can have a ... A leiomyosarcoma, also known as LMS, is a rare malignant (cancerous) smooth muscle tumor. The origin of the word is from leio ...
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Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP (2018). "Uterine Leiomyosarcoma". Oncology Research and ...
"What Color Is Leiomyosarcoma". MedicineNet. "National Leiomyosarcoma Foundation". NLMSF. "Orange Coast Magazine". December 2004 ...
"Leiomyosarcoma of the esophagus". Dis Esophagus. 16 (2): 142-4. PMID 12823215. M. Loui Thomas; Subhada Vivek Chiplunkar; Urmila ... "Leiomyosarcoma of the esophagus". Dis Esophagus. 16 (2): 142-4. PMID 12823215. M. Loui Thomas; Subhada Vivek Chiplunkar; Urmila ... "Leiomyosarcoma of the esophagus". Dis Esophagus. 16 (2): 142-4. PMID 12823215. M. Loui Thomas; Subhada Vivek Chiplunkar; Urmila ...
... such as leiomyosarcoma. Bevacizumab has been studied as a treatment for cancers that grow from the nerve connecting the ear and ... "Role of bevacizumab in uterine leiomyosarcoma". Critical Reviews in Oncology/Hematology. 126: 45-51. doi:10.1016/j.critrevonc. ...
Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de Médecine de Lyon. 52 (192): ...
"Trabectedin Superior to Dacarbazine for Leiomyosarcoma, Liposarcoma". Cancer Network. 21 September 2015. Archived from the ... and that the clinical efficacy data were mainly based on patients with liposarcoma and leiomyosarcoma. However, the pivotal ... for the treatment of liposarcoma and leiomyosarcoma that is either unresectable or has metastasized. Patients must have ...
Defect is in the fumarate hydratase gene in the long arm of chromosome 1. Leiomyosarcoma Elagolix/estradiol/norethindrone ...
Ann McGuiness, 65, American reproductive rights advocate, leiomyosarcoma. Nicky Moore, 75, English singer (Samson), ...
Keller NA, Godoy H (2015). "Leiomyosarcoma of the Vagina: An Exceedingly Rare Diagnosis". Case Reports in Obstetrics and ...
... leiomyosarcoma. Thomas Bruice, 93, American biochemist, complications from a stroke. Kofi Burbridge, 57, American rock multi- ...
... leiomyosarcoma. Trevor Fancutt, 88, South African tennis player. József Fitos, 63, Hungarian football player (Szombathelyi ...
It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport ... Smith HO, Blessing JA, Vaccarello L (January 2002). "Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of ...
In August 2022, McGuiness died of leiomyosarcoma of the lungs. Genzlinger, Neil (19 August 2022). "Ann McGuiness, Major Fund- ...
"Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma". J Cell Mol Med. 13 (9B): 3898-905. doi:10.1111/j. ...
"Prognostic significance of macrophage infiltration in leiomyosarcomas". Clinical Cancer Research. 14 (5): 1423-30. doi:10.1158/ ...
Malignant smooth muscle tumors are called leiomyosarcomas. Leiomyosarcomas are one of the more common types of soft-tissue ... vascular leiomyosarcomas is a malignant neoplasm that can be found in the inferior vena cava, pulmonary arteries and veins, and ...
She sought private medical investigation which found a left-atrial leiomyosarcoma. Connie kept her cancer diagnosis secret from ...
Coard, Kathleen C. M.; Fletcher, Horace (2002). "Leiomyosarcoma of the Uterus with a Florid Intravascular Component (' ...
In 2002, Price was treated for a leiomyosarcoma on her finger. The cancerous tumor was removed at a Nuffield Hospital near her ...
Leiomyosarcoma List of cutaneous conditions Inflammatory myofibroblastic tumour Shields, Jerry A.; Shields, Carol L.; Christian ... leiomyosarcoma, or inflammatory myofibroblastic tumor. The diagnosis of NF and its variants depends on a combination of ...
Broadway.com reported that she died of leiomyosarcoma, a rare cancer. Roberts, Sam (December 23, 2015). "Patricia Elliott, Tony ...
Rarer forms of tubal neoplasm include leiomyosarcoma, and transitional cell carcinoma. As the tumor is often enmeshed with the ...
Bassist/vocalist David J. Keyes died in July 2019 from leiomyosarcoma. Betty Thatcher (born 16 February 1944), the band's non- ...
Hubbard, G. B.; Fletcher, K. C. (1985). "A seminoma and a leiomyosarcoma in an albino African lungfish (Protopterus dolloi)". ...
... leiomyosarcoma. Mo Abbaro, 82, Sudanese-born British potter. Christopher Armishaw, 63, English cricketer (Derbyshire). Rafiq ...
"The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year ... The original description employed the then-prevailing terminology of gastric epithelioid leiomyosarcoma. Subsequent advances in ... The three classically associated tumors are a subset of gastric epithelioid leiomyosarcoma (it is now known that this subset is ...
... died of leiomyosarcoma on March 11, 2016, aged 83. Van Gelder, Lawrence (October 26, 1996). "Eat and Be ... Deaths from leiomyosarcoma, 20th-century American journalists, Columbia College (New York) alumni). ...
Uterine leiomyosarcomas come from the smooth muscle in the muscle layer of the uterus. Cutaneous leiomyosarcomas derive from ... "Leiomyosarcoma - NCI". www.cancer.gov. 2020-06-22. Retrieved 2023-10-04. "Basic info". Leiomyosarcoma.info. Archived from the ... leiomyosarcomas appear to grow from the muscle layer of a blood vessel (the tunica media). Thus, a leiomyosarcoma can have a ... A leiomyosarcoma, also known as LMS, is a rare malignant (cancerous) smooth muscle tumor. The origin of the word is from leio ...
Of this uncommon group of highly malignant neoplasms, the leiomyosarcoma is the most common histiotype. ... As many as 50% of the leiomyosarcomas occurring in the small intestine are found in the ileum. Relatively few leiomyosarcomas ... encoded search term (Intestinal Leiomyosarcoma) and Intestinal Leiomyosarcoma What to Read Next on Medscape ... and leiomyosarcomas occur more distally. Depending on the study reviewed, the primary sites of occurrence of leiomyosarcomas ...
Learn more about childhood leiomyosarcoma, symptoms, treatment and more at Dana-Farber Cancer Institute. ... What Is Childhood Leiomyosarcoma?. Leiomyosarcoma is a very rare, but very treatable cancer. It is a type of soft tissue ... Bone leiomyosarcoma. The exact cause of childhood leiomyosarcoma is not entirely understood, but studies suggest that genetics ... How We Treat Childhood Leiomyosarcoma. Surgery to remove the tumor is the primary treatment for childhood leiomyosarcoma, ...
Leiomyosarcoma. Disease definition A rare soft tissue sarcoma characterized by a malignant space-occupying lesion most commonly ...
PTC596-LMS (Leiomyosarcoma) - Clinical Trial. What is the Purpose of this Study?. ... Adults ages 18+ who are diagnosed with locally advanced leiomyosarcoma.. For more information on who can participate in this ... called unesbulin is a safe and effective option that can help people with a type of soft tissue sarcoma called leiomyosarcoma. ...
Discover the rarity of leiomyosarcoma of the breast and its treatment strategy in this case report. Explore clinical ... Primary breast leiomyosarcoma: case report and literature review () Fatima Zahra EL Mrabet, Hanane El kacemi, Omar El Mesbahi ... PURPOSE: Leiomyosarcoma of the breast is extremely rare. To date, the factors that are predictive of patient prognosis have not ... 2003) Primary leiomyosarcoma of the breast: A case report with review of the literature, The Breast Journal, 9, 494-496. doi: ...
About Leiomyosarcoma Leiomyosarcoma (LMS) is a rare and aggressive cancer found in smooth muscle tissue. LMS is one of the more ... "Leiomyosarcoma is an aggressive soft tissue sarcoma that has significant high unmet medical need, especially for those patients ... "Leiomyosarcoma is a particularly aggressive tumor type that desperately requires new treatment options for patients," said ... Preliminary Results Presented at ASCO Demonstrated Promising Clinical Efficacy with Unesbulin in Leiomyosarcoma Study ...
Leiomyosarcoma patients with high expression of GAS6 or PROS1 present a significantly worse PFS. Leiomyosarcoma patients, ... Leiomyosarcoma (LMS) are 15% of adult sarcomas and remain seldom curable in metastatic phase. The TAM receptors and their ... Leiomyosarcoma cells were seeded into 96-wells plates at a density of 2000-5000 cells per well. Cells were allowed to adhere ... Leiomyosarcoma patients expressing higher levels of GAS6 and/or PROS1 are more prone to relapse and/or develop metastasis in ...
In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene ... Abnormalities of the p53 MDM2 and DCC genes in human leiomyosarcomas Br J Cancer. 1994 Jun;69(6):1052-8. doi: 10.1038/bjc. ... In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene ... Except for evidence of a rearrangement in a single leiomyosarcoma cell line, SK-UT-1, we have found no direct evidence to ...
This research supports the further study of identified therapeutic targets in leiomyosarcoma in the hopes of taking one or more ... in supporting leiomyosarcoma research. LMSdr and LSSI have come together to fund three earlier leiomyosarcoma grants, and we ... Leiomyosarcoma Research. ---Collagen Deletion. ---Mir-17-92 Dysregulation. ---Mouse Model. ---MicroRNA Deregulation. ---Novel ... Leiomyosarcoma. Research Grants. The Initiative has funded five LMS research grants and one study open to several types of ...
We present the case of a 67-year-old woman with lung metastasis after eighteen years since uterine leiomyosarcoma diagnosis and ... this disease-free interval is the longest among previous reports of pulmonary metastasis of uterine leiomyosarcoma. ... Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% ... Careful followup after treatment of the uterine leiomyosarcoma is recommended because metastatic leiomyosarcoma can possibly ...
An Introduction to Leiomyosarcoma of the Bone and Soft Tissue. Available at: http://sarcomahelp.org/leiomyosarcoma.html. ... liposarcoma and leiomyosarcoma - where there are limited available alternatives," said George D. Demetri, M.D.,+ Director of ... or leiomyosarcoma (LMS) who received a prior anthracycline-containing regimen. The approval was based on recently published ... for the Treatment of Patients with Unresectable or Metastatic Liposarcoma or Leiomyosarcoma, Two Common Subtypes of Soft Tissue ...
Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases Subject Area: Oncology , Womens and Childrens Health ... Lin Gong, Hui Liu, Kai-Xuan Yang, Zhi-Lan Peng; Stage IV Primary Vaginal Leiomyosarcoma with Lung and Breast Metastases. Breast ... Case Report: We present the first report of a FIGO stage IV primary vaginal leiomyosarcoma with metastases to the lung and left ... To our knowledge, metastasis of vaginal leiomyosarcoma to the breast has not been previously reported in the literature. ...
Of this uncommon group of highly malignant neoplasms, the leiomyosarcoma is the most common histiotype. ... As many as 50% of the leiomyosarcomas occurring in the small intestine are found in the ileum. Relatively few leiomyosarcomas ... encoded search term (Intestinal Leiomyosarcoma) and Intestinal Leiomyosarcoma What to Read Next on Medscape ... and leiomyosarcomas occur more distally. Depending on the study reviewed, the primary sites of occurrence of leiomyosarcomas ...
Information about the SNOMED CT code 400011005 representing Leiomyosarcoma - category. ... Leiomyosarcoma - category 400011005 removed: 2021-09-30. ancestors. sorted most to least specific ... Printed 2023-09-22 from https://www.findacode.com/snomed/400011005--leiomyosarcoma-category.html. Copyright © 2000-2023 ...
From 12 epithelioid leiomyosarcomas, we selected 5 that had: 1) clear cell areas and 2) spindle cell areas that were at least ... we investigated HMB-45 expression in epithelioid uterine leiomyosarcomas with clear cell areas. ... Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa Am J Surg Pathol. 2004 ... From 12 epithelioid leiomyosarcomas, we selected 5 that had: 1) clear cell areas and 2) spindle cell areas that were at least ...
Methods We stained a series of uterine leiomyosarcomas (n=26) with DOG1 and with CD117 (c-kit), another marker of GIST. ... Uterine leiomyosarcomas should be added to the list of mesenchymal neoplasms which may be DOG1 positive. ... Results DOG1 immunoreactivity was present in seven of 26 (27%) leiomyosarcomas. Staining was focal in five cases and diffuse in ... Following the identification of DOG1 immunoreactivity in a uterine leiomyosarcoma, we wished to ascertain how prevalent DOG1 ...
... expedite a diagnosis of Uterine Leiomyosarcoma, sometimes incorrectly called a cancerous fibroid. We work with women in their ... Uterine leiomyosarcoma is an aggressive form of cancer that is difficult to treat.. It unfortunately may often have a poor ... Patients with leiomyosarcoma are typically treated by a gynecologic oncologist, who will order a CT scan and/or MRI and PET ... Leiomyosarcoma of the uterus is an extremely rare form of cancerous fibroid that can often present just like a uterine fibroid ...
Diagnosed with Leiomyosarcoma back in August 2021. had surgery to remove mass in upper right groin that same month. July 29th ... I too have leiomyosarcoma and had 2 nodules removed from my right lung on 3 October. I have been told that there is not any ... Diagnosed with Leiomyosarcoma back in August 2021. had surgery to remove mass in upper right groin that same month. July 29th ... Leiomyosarcoma: What can I expect now?. Posted by kkhersh @kkhersh, Oct 10, 2022 ...
Multiple Cases Panel Discussion: S2 Level Sacrectomy for Sacral Mass, Myxofibrosarcoma, and Leiomyosarcoma. By Penn Medicine ...
Coexisting primary pulmonary leiomyosarcoma (PPL) with pulmonary Aspergillosis in immunocompetent patients is a rare occurrence ... Primary pulmonary leiomyosarcoma with coexistent pulmonary aspergillosis: a case report. Primary pulmonary leiomyosarcoma with ... Primary pulmonary leiomyosarcoma in a forty-year-old woman. Case Rep Oncol. 2021 Sep-Dec;14(3):1333-6. PubMed , Google Scholar ... A case of primary pulmonary leiomyosarcoma. Respir Med Case Rep. 2019 May 27;27:100863. PubMed , Google Scholar ...
The following leiomyosarcoma cell lines were purchased from the ATCC: SK-LMS1 (ATCC® HTB-88™, leiomyosarcoma of the vulva), SK- ... Keywords: leiomyosarcoma; 5-azacitidine; Guadecitabine. Abbreviations: LMS: leiomyosarcoma; Aza: 5-azacitidine; DAC: Decitabine ... Leiomyosarcoma cell lines showed decrease in tumorigenesis when treated with Guadecitabine. Given the remarkable in vitro anti- ... Leiomyosarcoma cell lines showed variable responses to epigenetic drugs in vitro. The cellular viability of three ...
Tag Archives: leiomyosarcoma. Susan Jennifer Titus. Posted on December 17, 2017 by barb crews , Comments Off on Susan Jennifer ... Another Leiomyosarcoma patient called her Rocky. Yes, she was and is a Rocky. Ever since she became a cancer warrior her ... the disease along with helping others learn how to both fight and learn how to accept that wicked diagnosis of Leiomyosarcoma. ...
Does Lymphadenectomy Improve Survival in Uterine Leiomyosarcoma?. International Journal of Gynecologic Cancer 2015;25:1031-1036 ...
Uterine leiomyosarcoma. Uterine leiomyosarcomas grow in the muscle of the uterus, whats called the myometrium, according to ... and it turned out to be a leiomyosarcoma," Sharon Anderson, founder of Leiomyosarcoma Support & Direct Research Foundation, ... "There was no research about estrogen receptors in leiomyosarcoma. We took out my ovaries and then went on a breast cancer drug ... In 2021, further testing revealed she had stage 4 uterine leiomyosarcoma, a rare cancer of the smooth muscles in the uterus. ...
Drugs offered: leiomyosarcoma trial.. Havent missed a day, or a dose. No titania unforgivable at all. Theyll keep an eye on ...
Get Information on Leiomyosarcoma Cancer & Morcellators here. Get the medical and legal support you and your family deserve. ...
Study Name: Pazopanib for Treating Uterine Leiomyosarcoma. Condition: Uterine Leiomyosarcoma. Date: 2015-02-17. Interventions: ... Study Name: Activity of Trabectedin or Gemcitabine + Docetaxel in Uterine Leiomyosarcoma. Condition: Leiomyosarcoma. Date: 2014 ... Leiomyosarcoma - 25 Studies Found. Status. Study Recruiting. Study Name: Efficacy of Gemcitabine With Pazopanib as Second Line ... Leiomyosarcoma. Date: 2014-09-05. Interventions: Drug: Trabectedin Trabectedin administered at a dose of 1.5 mg/m2 - 1.3 mg/m2 ...
This report describes a case of rapidly progressive retroperitoneal pleomorphic leiomyosarcoma that was favorably controlled by ... The immunohistochemical diagnosis was pleomorphic leiomyosarcoma with high-grade malignancy and aggressive proliferative ... combination chemotherapy and radiotherapy controlled a rapidly progressive retroperitoneal pleomorphic leiomyosarcoma. ... such as pleomorphic leiomyosarcoma, often invade or displace vital organs in the abdominal cavity and exhibit an aggressive ...
Category: Leiomyosarcoma. Leiomyosarcoma: Heres what you need to know about this rare form of cancer.. Dr. Rich: In my last ... Worried about fibroid cancer (Leiomyosarcoma)? Heres what you need to know.. Dr. Rich: In my last video on fibroids, I ... mentioned the rare but significant risk of something called fibroid cancer, also known as leiomyosarcoma. How common is it and ... video on fibroids, I mentioned the rare but significant risk of something called fibroid cancer, also known as leiomyosarcoma. ...
  • Uterine leiomyosarcomas come from the smooth muscle in the muscle layer of the uterus. (wikipedia.org)
  • Leiomyosarcoma of the uterus is an extremely rare form of cancerous fibroid that can often present just like a uterine fibroid. (txfertility.com)
  • A leiomyosarcoma may cause symptoms indistinguishable from those of a fibroid, ranging from mild to very significant, depending on its size and location within in the uterus. (txfertility.com)
  • Leiomyosarcomas are sporadic malignant tumors that frequently arise from soft tissues, smooth muscles of the uterus, or gastrointestinal tract. (panafrican-med-journal.com)
  • In 2021, further testing revealed she had stage 4 uterine leiomyosarcoma, a rare cancer of the smooth muscles in the uterus. (yahoo.com)
  • Leiomyosarcoma of the corpus uteri is a rare malignant mesenchymal tumor of smooth muscle origin characterized histologically by spindle and/or pleomorphic cells often forming disorganized fascicles with tumor cell necrosis and macroscopically by a large soft usually intramural mass with irregular borders and necrotic and hemorrhagic areas located in the uterus. (globalgenes.org)
  • The V79 cell line was used in most of the experiments, derived from Chinese-hamster embryo lung, along with the HT cell line, derived from a human teratocarcinoma and the SK-UT-1 cell line, derived from a human leiomyosarcoma of the uterus. (cdc.gov)
  • A leiomyosarcoma, also known as LMS, is a rare malignant (cancerous) smooth muscle tumor. (wikipedia.org)
  • Leiomyosarcoma is very treatable, with 80% success rate if the tumor is completely removed. (dana-farber.org)
  • Surgery to remove the tumor is the primary treatment for childhood leiomyosarcoma, sometimes followed by chemotherapy and radiation therapy to destroy any cancer cells that may have spread beyond the tumor, and to prevent a recurrence. (dana-farber.org)
  • Leiomyosarcoma is a particularly aggressive tumor type that desperately requires new treatment options for patients," said Brian Van Tine , M.D., Ph.D., Sarcoma Program, Washington University and lead clinical investigator. (prnewswire.com)
  • Dr. Matt van de Rijn explains the difficulty of treating LMS: 'The challenge that leiomyosarcoma poses for the treating physician is that surgery remains the major avenue of therapy for this tumor. (sarcomahelp.org)
  • This means that when a tumor can not be completely resected, or when a tumor has already metastasized, that there are no targeted therapies that specifically will attack the leiomyosarcoma cells. (sarcomahelp.org)
  • The resected tumor was histologically identified as low-grade leiomyosarcoma. (hindawi.com)
  • These results were compared with the histological data of the previous tumor, and a final diagnosis of pulmonary metastasis was obtained: the immune histochemistry supported the diagnosis of metastases of leiomyosarcoma. (hindawi.com)
  • Patients with leiomyosarcoma are typically treated by a gynecologic oncologist, who will order a CT scan and/or MRI and PET scan to assess the pelvic area and biopsy the tumor. (txfertility.com)
  • The treatment options depend on whether a uterine tumor is a leiomyosarcoma or not, for example, it could be a leiomyoma or a fibroma. (epainassist.com)
  • Additionally, researchers are continuing to find new ways to diagnose leiomyosarcoma in addition to the standard imaging techniques with the help of blood tests for the levels of LDH, body weight of the patient, and size of the tumor. (epainassist.com)
  • Primary leiomyosarcomas of the gastrointestinal tract in the post-gastrointestinal stromal tumor era. (medscape.com)
  • The tumor, which measured 3.5 x 2.5 x 2.0 cm in size, was enucleated using videoassisted thoracic surgery and was diagnosed to be a very rare myxoid leiomyosarcoma with a thorough pathologic examination. (elsevierpure.com)
  • Leiomyosarcoma, tumor of the foot, smooth muscle cell tumor. (faoj.org)
  • We report a case of primary leiomyosarcoma of the breast occurring in young female patient which was successfully treated by surgery and radiotherapy. (scirp.org)
  • According to literature data, primary leiomyosarcoma is characterized by a better prognosis compared with other breast sarcomas, To date, the factors that are predictive of patient prognosis have not been identified. (scirp.org)
  • 2003) Primary leiomyosarcoma of the breast: A case report with review of the literature, The Breast Journal, 9, 494-496. (scirp.org)
  • Primary Leiomyosarcoma of the Kidney : A Case Report and Review of Literature', Iranian Journal of Pathology , 5(3), pp. 154-157. (iranpath.org)
  • In this study, we investigated HMB-45 expression in epithelioid uterine leiomyosarcomas with clear cell areas. (nih.gov)
  • however, it is advisable to designate them as uterine leiomyosarcomas. (nih.gov)
  • Methods We stained a series of uterine leiomyosarcomas (n=26) with DOG1 and with CD117 (c-kit), another marker of GIST. (bmj.com)
  • Uterine leiomyosarcomas should be added to the list of mesenchymal neoplasms which may be DOG1 positive. (bmj.com)
  • Most uterine leiomyosarcomas are found by chance during hysterectomy surgery to remove fibroid tumors. (txfertility.com)
  • Of this uncommon group of highly malignant neoplasms, the leiomyosarcoma is the most common histiotype. (medscape.com)
  • Primary pulmonary leiomyosarcomas is a subtype of pulmonary sarcoma, accounting for less than 0.5% of all malignant pulmonary neoplasms. (panafrican-med-journal.com)
  • Leiomyosarcomas (LMS), theirs malignant counterpart, comprise 7% of head and neck sarcomas [2]. (peertechzpublications.org)
  • Leiomyosarcoma patients, especially those whom develop metastasis, express higher levels of TYRO3 and GAS6. (nature.com)
  • We present the case of a 67-year-old woman with lung metastasis after eighteen years since uterine leiomyosarcoma diagnosis and its following surgical resection. (hindawi.com)
  • To our knowledge, this disease-free interval is the longest among previous reports of pulmonary metastasis of uterine leiomyosarcoma. (hindawi.com)
  • To our knowledge, metastasis of vaginal leiomyosarcoma to the breast has not been previously reported in the literature. (karger.com)
  • Right ventricular metastasis of leiomyosarcoma. (lu.se)
  • Dive into the research topics of 'Right ventricular metastasis of leiomyosarcoma. (lu.se)
  • Although leiomyosarcomas are rare, they belong to of the more common types of soft-tissue sarcoma, representing 10 to 20% of new cases. (wikipedia.org)
  • We are doing this study to find out if a study drug called unesbulin is a safe and effective option that can help people with a type of soft tissue sarcoma called leiomyosarcoma. (dukehealth.org)
  • Leiomyosarcoma is an aggressive soft tissue sarcoma that has significant high unmet medical need, especially for those patients who have relapsed or are refractory to current treatments. (prnewswire.com)
  • The LeioMyoSarcoma Direct Research Foundation and the Liddy Shriver Sarcoma Initiative have come together to fund a $150,000 grant for promising leiomyosarcoma research at Stanford University. (sarcomahelp.org)
  • That was an excellent suggestion, as at that time I was orienting myself on which sarcoma I wanted to go into in more detail, and I felt that leiomyosarcomas were relatively understudied within the group of soft tissue tumors, while they constituted a considerable percentage of these tumors. (sarcomahelp.org)
  • Leiomyosarcoma is a type of soft tissue sarcoma. (drallison.org)
  • As with all forms of sarcoma, leiomyosarcomas can develop anywhere in the body, and the treatment options vary depending on where the tumors are located, the grade and stage, and the patient's overall health profile, among other factors. (drallison.org)
  • Uterine leiomyosarcoma (uLMS) is an aggressive subtype of soft- tissue sarcoma with frequent metastatic relapse after curative surgery . (bvsalud.org)
  • Leiomyomas are benign smooth muscle tumors that have overlapping features with leiomyosarcomas. (wikipedia.org)
  • [ 1 ] Intestinal leiomyosarcomas are mesenchymal tumors of smooth muscle origin. (medscape.com)
  • In the past, GI stromal tumors ( GISTs ) were misdiagnosed as leiomyosarcomas. (medscape.com)
  • Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
  • Dana-Farber/Boston Children's Cancer and Blood Disorders Center provides comprehensive medical and surgical care for children with childhood leiomyosarcoma in our Bone and Soft Tissue Tumors Program . (dana-farber.org)
  • It's important to note that, even though they sound similar, benign fibroid tumors (or "leiomyomas") are quite different from leiomyosarcomas. (txfertility.com)
  • Primary intestinal leiomyosarcomas in children are rare tumors. (mcmaster.ca)
  • There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)
  • Leiomyosarcoma is a very rare, but very treatable cancer. (dana-farber.org)
  • Children with other forms of cancer, such as retinoblastoma , may be at higher risk for developing leiomyosarcoma as adults. (dana-farber.org)
  • Leiomyosarcoma (LMS) is a rare and aggressive cancer found in smooth muscle tissue. (prnewswire.com)
  • Leiomyosarcoma (LMS) is a rare and aggressive cancer. (sarcomahelp.org)
  • Uterine leiomyosarcoma (ULMS) is an uncommon aggressive uterine cancer characterized by a poor prognosis. (hindawi.com)
  • Uterine leiomyosarcoma is an aggressive form of cancer that is difficult to treat. (txfertility.com)
  • Get Information on Leiomyosarcoma Cancer & Morcellators here. (leiomyosarcoma.org)
  • Leiomyosarcoma: Here's what you need to know about this rare form of cancer. (farnammd.com)
  • Dr. Rich: In my last video on fibroids, I mentioned the rare but significant risk of something called fibroid cancer, also known as leiomyosarcoma. (farnammd.com)
  • Worried about fibroid cancer (Leiomyosarcoma)? (farnammd.com)
  • Leiomyosarcoma is a type of cancer that affects dogs, specifically the smooth muscle cells. (vetartwork.com)
  • The treatment for leiomyosarcoma in dogs depends on the location and stage of the cancer. (vetartwork.com)
  • Women who have had a type of eye cancer called retinoblastoma due to a congenital anomaly of a copy of the RB gene are at an increased risk of developing leiomyosarcomas. (epainassist.com)
  • Stomach and intestinal cancer is also known as leiomyosarcoma, which arises from the smooth muscles of the stomach and intestines. (petlifeus.com)
  • Primary cardiac leiomyosarcoma is a very rare type of heart cancer that arises from the smooth muscle cell tissues of the heart. (withoutaribbon.org)
  • Primary Cardiac Leiomyosarcoma is rare cancer, meaning it is not as well known as other forms of cancer. (withoutaribbon.org)
  • If you suffer from rare cancer such as Primary Cardiac Leiomyosarcoma, we can help and support you through your journey thanks to the generous donations we receive. (withoutaribbon.org)
  • Leiomyosarcoma accounts for approximately 10% of all diagnoses for this form of cancer, making it the third most common form (overall, soft tissue cancer is very rare). (drallison.org)
  • Leiomyosarcoma (cancer of smooth muscle cells) can develop in the wall of the stomach. (msdmanuals.com)
  • If cancer has already spread (metastasized) to other parts of the body at the time a leiomyosarcoma is found, then chemotherapy may lead to slightly longer survival. (msdmanuals.com)
  • Leiomyomas are seen in pre-menopausal women and are symptomatic 20-50% of the time, while leiomyosarcomas, the most common uterine sarcomas, are seen in older post-menopausal women with 40-60 being the peak age incidence. (wikipedia.org)
  • The exact cause of childhood leiomyosarcoma is not entirely understood, but studies suggest that genetics may play a role in the formation of all soft tissue sarcomas. (dana-farber.org)
  • Sarcomas comprise less than 1% of all primary breast neoplasms and only a minority of these are leiomyosarcomas. (scirp.org)
  • Leiomyosarcoma (LMS) are 15% of adult sarcomas and remain seldom curable in metastatic phase. (nature.com)
  • Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5-1/100,000/year. (hindawi.com)
  • Leiomyosarcomas (LMS) are sarcomas that comprise spindle-cell neoplasms that develop from smooth muscle tissue and affect approximately 1 out of 100,000 Americans per year [ 2 - 4 ]. (oncotarget.com)
  • Retroperitoneal sarcomas (RPS), such as pleomorphic leiomyosarcoma, often invade or displace vital organs in the abdominal cavity and exhibit an aggressive clinical course. (biomedcentral.com)
  • Among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. (iranpath.org)
  • Approximately 350 spindle cell sarcomas are diagnosed each year and of these only eight percent are leiomyosarcomas. (faoj.org)
  • I was diagnosed with peritoneal Leiomyosarcoma in August 2022. (mayoclinic.org)
  • Cutaneous leiomyosarcomas derive from the pilo-erector muscles in the skin. (wikipedia.org)
  • The best prognosis is cutaneous leiomyosarcoma and arises from the small muscles in the hair follicles. (faoj.org)
  • The prognosis for patients with purely cutaneous leiomyosarcoma is an unusually good 90% survival. (faoj.org)
  • To clarify the nature of leiomyosarcoma of the breast, and also to establish the proper treatment strategy, we report this case We report this case while discussing The Clinical presentation, diagnosis, therapy and pathologic feature. (scirp.org)
  • Conclusions Since GISTs have rarely been described as primary uterine neoplasms, the presence of DOG1 immunoreactivity in a uterine leiomyosarcoma may result in diagnostic confusion, and a panel of markers is necessary for diagnosis. (bmj.com)
  • She fought the disease along with helping others learn how to both fight and learn how to accept that wicked diagnosis of Leiomyosarcoma. (barbcrews.com)
  • The immunohistochemical diagnosis was pleomorphic leiomyosarcoma with high-grade malignancy and aggressive proliferative features. (biomedcentral.com)
  • A diagnosis of leiomyosarcoma in your dog can be very difficult and emotional. (vetartwork.com)
  • By the CT-guided biopsy, the diagnosis of leiomyosarcoma with faint hemorrhage was made on immunohistochemical stain. (radiologypaper.com)
  • The aim of this study is to analyse and compare the clinical features of leiomyoma and leiomyosarcoma, because they help in the differential diagnosis. (bvsalud.org)
  • pazopanib is the targeted therapy used in metastatic leiomyosarcoma as second line and is well tolerated. (wikipedia.org)
  • Although both originate from smooth muscle, it is important to note that leiomyomas do not mature to become leiomyosarcomas. (wikipedia.org)
  • Our Austin fertility doctors regularly counsel patients who are referred to see us for treatment of their fibroids about the many differences between leiomyomas and leiomyosarcomas. (txfertility.com)
  • Oct. 23, 2015 /PRNewswire/ -- Janssen Biotech, Inc. today announced the U.S. Food and Drug Administration (FDA) has approved YONDELIS ® (trabectedin) for the treatment of patients with unresectable (unable to be removed with surgery) or metastatic liposarcoma (LPS) or leiomyosarcoma (LMS) who received a prior anthracycline-containing regimen. (prnewswire.com)
  • Inclusion criteria: * Histologically proven primary high risk leiomyosarcoma (LMS) or Liposarcoma (LPS) of retroperitoneal space or infra-peritoneal spaces of pelvis (LPS: Grade 3 DDLPS OR confirmed Grade 2 DDLPS on biopsy only if FNCLCC score = 5 AND clear necrosis on imaging. (who.int)
  • Primary high risk leiomyosarcoma or dedifferentiated liposarcoma of the retroperitoneum. (who.int)
  • Primary oral leiomyosarcomas are exceptionally rare lesions often associated with poor prognosis. (peertechzpublications.org)
  • Records of oral leiomyoma and leiomyosarcoma from Oral Pathology Department of Dental School at University of São Paulo during the period 1962-2010 were analysed. (bvsalud.org)
  • Intestinal leiomyosarcomas are fairly rare, with a frequency of around 1.4 cases per 100,000 patients. (medscape.com)
  • The authors report the 28th case of pediatric intestinal leiomyosarcoma and its follow-up, that of a newborn presenting with intestinal obstruction. (mcmaster.ca)
  • Leiomyosarcomas are rare mesenchymal neoplasms characterized by a smooth muscle differentiation pattern. (oncotarget.com)
  • PTCT ) today announced encouraging preliminary safety and efficacy results from its Phase 1B study of unesbulin (PTC596) in advanced leiomyosarcoma (LMS) patients. (prnewswire.com)
  • The preliminary results demonstrate promising early efficacy in patients with advanced leiomyosarcoma. (prnewswire.com)
  • Leiomyosarcoma patients with high expression of GAS6 or PROS1 present a significantly worse PFS. (nature.com)
  • Coexisting primary pulmonary leiomyosarcoma (PPL) with pulmonary Aspergillosis in immunocompetent patients is a rare occurrence. (panafrican-med-journal.com)
  • In one study, 59% of patients with leiomyosarcomas were symptomatic. (medscape.com)
  • In this series, which reviewed more than 11,000 cases, 6% of the patients with leiomyosarcomas also had a history of Crohn disease. (medscape.com)
  • Leiomyosarcoma was more frequent in patients up to 50 years and the jaws were the most affected sites. (bvsalud.org)
  • Patients in the standard arm (surgery alone) will undergo large en- bloc curative intent surgery will be performed within 4 weeks following randomization. (who.int)
  • Il s'agissait d'une étude descriptive avec une collecte rétrospective des données des patients hospitalisés et/ou reçus en consultation dans le service de Néphrologie du CHU de Yopougon à Abidjan entre Janvier 1991 et Décembre 2015. (bvsalud.org)
  • L'ectopie rénale croisée a été notée chez deux patients et l'ectopie bilatérale chez quatre dont un cas de fusion en fer à cheval. (bvsalud.org)
  • Le contrôle radiologique effectué chez les patients ayant présenté un traumatisme au stade IV a montré une reconstruction du rein et une absence d'extravasion de produit de contraste.Conclusion :Les traumatismes du rein sont de plus en plus fréquents. (bvsalud.org)
  • Leiomyosarcoma of the breast is extremely rare. (scirp.org)
  • Although experts do not know the exact reason for the cause of leiomyosarcoma (which is a very rare disease), some researches are being carried out to determine the causes, the available options to avoid the disease, diagnose using other imaging techniques and better treatment options which do not cause more side effects. (epainassist.com)
  • The authors present a case report of a rare leiomyosarcoma. (faoj.org)
  • 3] Leiomyosarcoma in the foot is relatively rare and infrequently reported. (faoj.org)
  • Primary pulmonary leiomyosarcomas (PPLs) are uncommon, with few reported cases in the literature [ 1 ]. (panafrican-med-journal.com)
  • This report describes a case of rapidly progressive retroperitoneal pleomorphic leiomyosarcoma that was favorably controlled by debulking surgery followed by combination chemotherapy and radiotherapy. (biomedcentral.com)
  • Multimodal therapy with debulking surgery, combination chemotherapy and radiotherapy controlled a rapidly progressive retroperitoneal pleomorphic leiomyosarcoma. (biomedcentral.com)
  • The chemotherapy drug imatinib has been found to be effective in treating leiomyosarcoma that cannot be treated with surgery. (msdmanuals.com)
  • We present the first report of a FIGO stage IV primary vaginal leiomyosarcoma with metastases to the lung and left breast. (karger.com)
  • It is important to be aware of the signs and symptoms of leiomyosarcoma in dogs so that you can catch it early and seek veterinary care. (vetartwork.com)
  • At most other primary sites-retroperitoneal extremity (in the abdomen, behind the intestines), truncal, abdominal organs, etc.-leiomyosarcomas appear to grow from the muscle layer of a blood vessel (the tunica media). (wikipedia.org)
  • Whereas fibroids affect women of all reproductive ages, leiomyosarcomas typically present in a woman's 50s and 60s. (txfertility.com)
  • It is known that these factors affect a woman's risk of leiomyosarcoma. (epainassist.com)
  • The rarest type is vascular leiomyosarcomas. (faoj.org)
  • 2004) Leiomyosarcoma of the breast: A pathologic and comparative genomic hybridization study of two cases. (scirp.org)
  • The initial treatment of choice of uterine leiomyosarcoma is the surgical resection and, in addition to this, adjuvant therapy (including chemotherapy and radiotherapy) can be used to reduce the risk of recurrence, despite the fact that the clinical efficacy is still uncertain [ 2 ]. (hindawi.com)
  • Additional studies are required to explore potential therapeutic applications and mechanisms for leiomyosarcoma treatment. (oncotarget.com)
  • Healthcare professionals are also trying to analyze immunotherapies and other targeted therapies as a mode of treatment for leiomyosarcoma. (epainassist.com)
  • These medications may not have the same working mechanism as chemotherapy medications but they have shown to be effective when chemotherapy has no effect on the patient or there is a recurrence of leiomyosarcoma post treatment. (epainassist.com)
  • Treatment for subcutaneous leiomyosarcoma is resection and some authors suggest postoperative radiotherapy. (faoj.org)
  • Gastrointestinal leiomyosarcomas might come from smooth muscle in the GI tract, or alternatively, from a blood vessel. (wikipedia.org)
  • In this paper, we report a patient with leiomyosarcoma of the kidney presented with non-specific abdominal pain and a palpable mass. (iranpath.org)
  • A risk factor is anything that influences the likelihood that you get a disease, such as leiomyosarcoma. (epainassist.com)
  • Past medical history: One study reported a possible relationship between leiomyosarcomas and Crohn disease. (medscape.com)
  • De la Pena, J, Wapnir, I. (2008) Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclo-phosphamide exposure: A case report. (scirp.org)
  • 2004) Primitive leiomyosarcoma of the breast: case report and review of the literature. (scirp.org)
  • Gupta, R.K. (2007) Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. (scirp.org)
  • We report a case of leiomyosarcoma arising in the anterior mandibular gingiva, which is a non-prevalent site of occurrence. (peertechzpublications.org)
  • To our knowledge, this is only the second case of esophageal myxoid leiomyosarcoma reported in the literature. (elsevierpure.com)
  • Here, we report a case of subcutaneous leiomyosarcoma, which was initially diagnosed as a ganglionic cyst and was referred to podiatry by a primary care physician for evaluation. (faoj.org)
  • Leiomyosarcomas spread to the liver and peritoneum first. (medscape.com)
  • From 12 epithelioid leiomyosarcomas, we selected 5 that had: 1) clear cell areas and 2) spindle cell areas that were at least focally positive for desmin and caldesmon. (nih.gov)