Lethargy
Dog Diseases
Euthanasia, Animal
Fatal Outcome
Cat Diseases
Animals, Zoo
Air Conditioning
Dogs
Hyperammonemia
Enterocolitis
Sleep Stages
Infant Behavior
Carcinogenicity Tests
Cats
Rats, Inbred F344
Treatment Outcome
Boredom
Parkinson Disease, Postencephalitic
Encyclopedias as Topic
Sleep
Physiology
Best practice guidelines for the molecular genetic diagnosis of Type 1 (HFE-related) hereditary haemochromatosis. (1/28)
BACKGROUND: Hereditary haemochromatosis (HH) is a recessively-inherited disorder of iron over-absorption prevalent in Caucasian populations. Affected individuals for Type 1 HH are usually either homozygous for a cysteine to tyrosine amino acid substitution at position 282 (C282Y) of the HFE gene, or compound heterozygotes for C282Y and for a histidine to aspartic acid change at position 63 (H63D). Molecular genetic testing for these two mutations has become widespread in recent years. With diverse testing methods and reporting practices in use, there was a clear need for agreed guidelines for haemochromatosis genetic testing. The UK Clinical Molecular Genetics Society has elaborated a consensus process for the development of disease-specific best practice guidelines for genetic testing. METHODS: A survey of current practice in the molecular diagnosis of haemochromatosis was conducted. Based on the results of this survey, draft guidelines were prepared using the template developed by UK Clinical Molecular Genetics Society. A workshop was held to develop the draft into a consensus document. The consensus document was then posted on the Clinical Molecular Genetics Society website for broader consultation and amendment. RESULTS: Consensus or near-consensus was achieved on all points in the draft guidelines. The consensus and consultation processes worked well, and outstanding issues were documented in an appendix to the guidelines. CONCLUSION: An agreed set of best practice guidelines were developed for diagnostic, predictive and carrier testing for hereditary haemochromatosis and for reporting the results of such testing. (+info)Rift Valley fever virus lacking NSm proteins retains high virulence in vivo and may provide a model of human delayed onset neurologic disease. (2/28)
Rift Valley fever virus is a significant human and veterinary pathogen responsible for explosive outbreaks throughout Africa and the Arabian Peninsula. Severe acute disease in humans includes rapid onset hepatic disease and hemorrhagic fever or delayed onset encephalitis. A highly efficient reverse genetics system was developed which allowed generation of recombinant RVF viruses to assess the role of NSm protein in virulence in a rat model in which wild-type RVF virus strain ZH501 (wt-ZH501) results in 100% lethal hepatic disease 2-3 days post infection. While extensive genomic analysis indicates conservation of the NSm coding capability of diverse RVF viruses, and viruses deficient in NSs proteins are completely attenuated in vivo, comparison of wt-ZH501, a reverse genetics generated wt-ZH501 virus (R-ZH501), and R-ZH501 virus lacking the NSm proteins (R-DeltaNSm-ZH501) demonstrated that the NSm proteins were nonessential for in vivo virulence and lethality. Surprisingly, while 44% of R-DeltaNSm-ZH501 infected animals quickly developed lethal hepatic disease similar to wt- and R-ZH501, 17% developed delayed onset neurologic disease (lethargy, head tremors, and ataxia) at 13 days post infection. Such infections may provide the basis for study of both RVF acute hepatic disease and delayed onset encephalitic disease in humans. (+info)Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. (3/28)
(+info)Maternal depression and neurobehavior in newborns prenatally exposed to methamphetamine. (4/28)
(+info)Topiramate and adrenocorticotropic hormone (ACTH) as initial treatment for infantile spasms. (5/28)
(+info)Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial. (6/28)
(+info)Idiopathic lesions and visual deficits in the american lobster (Homarus americanus) from Long Island Sound, NY. (7/28)
In 1999, a mass mortality of the American lobster (Homarus americanus) occurred in western Long Island Sound (WLIS). Although the etiology of this event remains unknown, bottom water temperature, hypoxia, heavy metal poisoning, and pesticides are potential causal factors. Lobsters from WLIS continue to display signs of morbidity, including lethargy and cloudy grey eyes that contain idiopathic lesions. As the effect of these lesions on lobster vision is unknown, we used electroretinography (ERG) to document changes in visual function in lobsters from WLIS, while using histology to quantify the extent of physical damage. Seventy-three percent of lobsters from WLIS showed damage to photoreceptors and optic nerve fibers, including necrosis, cellular breakdown, and hemocyte infiltration in the optic nerves, rhabdoms, and ommatidia. Animals with more than 15% of their photoreceptors exhibiting damage also displayed markedly reduced responses to 10-ms flashes of a broad-spectrum white light. Specifically, maximum voltage (Vmax) responses were significantly lower and occurred at a lower light intensity compared to responses from lobsters lacking idiopathic lesions. Nearly a decade after the 1999 mortality event, lobsters from WLIS still appear to be subjected to a stressor of unknown etiology that causes significant functional damage to the eyes. (+info)Prenatal methadone exposure and neonatal neurobehavioral functioning. (8/28)
(+info)Lethargy is a state of extreme fatigue, drowsiness, and/or lack of energy. In a medical context, lethargy may refer to a reduced level of consciousness or awareness where an individual has difficulty staying awake or responding to stimuli. It can be a symptom of various medical conditions such as infections, neurological disorders, metabolic imbalances, or psychological issues. However, it is important to note that lethargy should be evaluated by a healthcare professional for proper diagnosis and treatment.
There is no medical definition for "dog diseases" as it is too broad a term. However, dogs can suffer from various health conditions and illnesses that are specific to their species or similar to those found in humans. Some common categories of dog diseases include:
1. Infectious Diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include distemper, parvovirus, kennel cough, Lyme disease, and heartworms.
2. Hereditary/Genetic Disorders: Some dogs may inherit certain genetic disorders from their parents. Examples include hip dysplasia, elbow dysplasia, progressive retinal atrophy (PRA), and degenerative myelopathy.
3. Age-Related Diseases: As dogs age, they become more susceptible to various health issues. Common age-related diseases in dogs include arthritis, dental disease, cancer, and cognitive dysfunction syndrome (CDS).
4. Nutritional Disorders: Malnutrition or improper feeding can lead to various health problems in dogs. Examples include obesity, malnutrition, and vitamin deficiencies.
5. Environmental Diseases: These are caused by exposure to environmental factors such as toxins, allergens, or extreme temperatures. Examples include heatstroke, frostbite, and toxicities from ingesting harmful substances.
6. Neurological Disorders: Dogs can suffer from various neurological conditions that affect their nervous system. Examples include epilepsy, intervertebral disc disease (IVDD), and vestibular disease.
7. Behavioral Disorders: Some dogs may develop behavioral issues due to various factors such as anxiety, fear, or aggression. Examples include separation anxiety, noise phobias, and resource guarding.
It's important to note that regular veterinary care, proper nutrition, exercise, and preventative measures can help reduce the risk of many dog diseases.
Euthanasia, when used in the context of animals, refers to the act of intentionally causing the death of an animal in a humane and peaceful manner to alleviate suffering from incurable illness or injury. It is also commonly referred to as "putting an animal to sleep" or "mercy killing." The goal of euthanasia in animals is to minimize pain and distress, and it is typically carried out by a veterinarian using approved medications and techniques. Euthanasia may be considered when an animal's quality of life has become significantly compromised and there are no reasonable treatment options available to alleviate its suffering.
A fatal outcome is a term used in medical context to describe a situation where a disease, injury, or illness results in the death of an individual. It is the most severe and unfortunate possible outcome of any medical condition, and is often used as a measure of the severity and prognosis of various diseases and injuries. In clinical trials and research, fatal outcome may be used as an endpoint to evaluate the effectiveness and safety of different treatments or interventions.
There are many diseases that can affect cats, and the specific medical definitions for these conditions can be quite detailed and complex. However, here are some common categories of feline diseases and examples of each:
1. Infectious diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include:
* Feline panleukopenia virus (FPV), also known as feline parvovirus, which can cause severe gastrointestinal symptoms and death in kittens.
* Feline calicivirus (FCV), which can cause upper respiratory symptoms such as sneezing and nasal discharge.
* Feline leukemia virus (FeLV), which can suppress the immune system and lead to a variety of secondary infections and diseases.
* Bacterial infections, such as those caused by Pasteurella multocida or Bartonella henselae, which can cause abscesses or other symptoms.
2. Neoplastic diseases: These are cancerous conditions that can affect various organs and tissues in cats. Examples include:
* Lymphoma, which is a common type of cancer in cats that can affect the lymph nodes, spleen, liver, and other organs.
* Fibrosarcoma, which is a type of soft tissue cancer that can arise from fibrous connective tissue.
* Squamous cell carcinoma, which is a type of skin cancer that can be caused by exposure to sunlight or tobacco smoke.
3. Degenerative diseases: These are conditions that result from the normal wear and tear of aging or other factors. Examples include:
* Osteoarthritis, which is a degenerative joint disease that can cause pain and stiffness in older cats.
* Dental disease, which is a common condition in cats that can lead to tooth loss, gum inflammation, and other problems.
* Heart disease, such as hypertrophic cardiomyopathy (HCM), which is a thickening of the heart muscle that can lead to congestive heart failure.
4. Hereditary diseases: These are conditions that are inherited from a cat's parents and are present at birth or develop early in life. Examples include:
* Polycystic kidney disease (PKD), which is a genetic disorder that causes cysts to form in the kidneys and can lead to kidney failure.
* Hypertrophic cardiomyopathy (HCM), which can be inherited as an autosomal dominant trait in some cats.
* Progressive retinal atrophy (PRA), which is a group of genetic disorders that cause degeneration of the retina and can lead to blindness.
"Animals, Zoo" is not a medical term. However, it generally refers to a collection of various species of wild animals kept in enclosures or exhibits for the public to view and learn about. These animals are usually obtained from different parts of the world and live in environments that attempt to simulate their natural habitats. Zoos play an essential role in conservation efforts, education, and research. They provide a unique opportunity for people to connect with wildlife and understand the importance of preserving and protecting endangered species and their ecosystems.
Air conditioning is the process of controlling and maintaining a comfortable indoor environment through the regulation of temperature, humidity, air movement, and cleanliness. It typically involves the use of mechanical systems that circulate and treat air to meet specific comfort requirements. The goal of air conditioning is to provide a comfortable, healthy, and productive indoor environment while also saving energy and reducing environmental impact.
In medical terms, air conditioning can be particularly important in healthcare settings such as hospitals and clinics, where maintaining proper temperature and humidity levels is essential for the health and well-being of patients and staff. Proper air conditioning can help prevent the growth of bacteria, viruses, and mold, reduce the spread of airborne particles, and minimize the risk of infection and illness.
Air conditioning systems in healthcare facilities may include specialized components such as HEPA filters, UV germicidal irradiation, and humidity control to provide a higher level of air quality and protection against infectious diseases. Regular maintenance and testing of these systems is also critical to ensure their proper functioning and to maintain a safe and healthy indoor environment.
Hypernatremia is a medical condition characterized by an abnormally high concentration of sodium (na+) in the blood, specifically a serum sodium level greater than 145 mEq/L. Sodium is an essential electrolyte that helps regulate water balance in and around your cells. It's crucial for many body functions, including the maintenance of blood pressure, regulation of nerve and muscle function, and regulation of fluid balance.
Hypernatremia typically results from a deficit of total body water relative to solute, which can be caused by decreased water intake, increased water loss, or a combination of both. Common causes include dehydration due to severe vomiting or diarrhea, excessive sweating, burns, kidney diseases, and the use of certain medications such as diuretics.
Symptoms of hypernatremia can range from mild to severe and may include thirst, muscle weakness, lethargy, irritability, confusion, seizures, and in extreme cases, coma or even death. Treatment typically involves correcting the underlying cause and gradually rehydrating the individual with intravenous fluids to restore normal sodium levels.
I believe there might be a misunderstanding in your question. "Dogs" is not a medical term or condition. It is the common name for a domesticated carnivore of the family Canidae, specifically the genus Canis, which includes wolves, foxes, and other extant and extinct species of mammals. Dogs are often kept as pets and companions, and they have been bred in a wide variety of forms and sizes for different purposes, such as hunting, herding, guarding, assisting police and military forces, and providing companionship and emotional support.
If you meant to ask about a specific medical condition or term related to dogs, please provide more context so I can give you an accurate answer.
Hyperammonemia is a medical condition characterized by an excessively high level of ammonia (a toxic byproduct of protein metabolism) in the blood. This can lead to serious neurological symptoms and complications, as ammonia is highly toxic to the brain. Hyperammonemia can be caused by various underlying conditions, including liver disease, genetic disorders that affect ammonia metabolism, certain medications, and infections. It is important to diagnose and treat hyperammonemia promptly to prevent long-term neurological damage or even death. Treatment typically involves addressing the underlying cause of the condition, as well as providing supportive care such as administering medications that help remove ammonia from the blood.
Enterocolitis is a medical condition that involves inflammation of the small intestine (enteritis) and large intestine (colitis). This condition can affect people of all ages, but it is most commonly seen in infants and young children. The symptoms of enterocolitis may include diarrhea, abdominal cramps, bloating, nausea, vomiting, fever, and dehydration.
There are several types of enterocolitis, including:
1. Infectious Enterocolitis: This type is caused by a bacterial, viral, or parasitic infection in the intestines. Common causes include Salmonella, Shigella, Escherichia coli (E. coli), and norovirus.
2. Antibiotic-Associated Enterocolitis: This type is caused by an overgrowth of harmful bacteria in the intestines following the use of antibiotics that kill off beneficial gut bacteria.
3. Pseudomembranous Enterocolitis: This is a severe form of antibiotic-associated enterocolitis caused by the bacterium Clostridioides difficile (C. diff).
4. Necrotizing Enterocolitis: This is a serious condition that primarily affects premature infants, causing inflammation and damage to the intestinal tissue, which can lead to perforations and sepsis.
5. Ischemic Enterocolitis: This type is caused by reduced blood flow to the intestines, often due to conditions such as mesenteric ischemia or vasculitis.
6. Radiation Enterocolitis: This type occurs as a complication of radiation therapy for cancer treatment, which can damage the intestinal lining and lead to inflammation.
7. Eosinophilic Enterocolitis: This is a rare condition characterized by an excessive buildup of eosinophils (a type of white blood cell) in the intestinal tissue, leading to inflammation and symptoms similar to those seen in inflammatory bowel disease.
Treatment for enterocolitis depends on the underlying cause and severity of the condition. It may include antibiotics, antiparasitic medications, probiotics, or surgery in severe cases.
New World camelids are a family of mammals (Camelidae) that are native to South America. The family includes four species: the llama (Lama glama), the alpaca (Vicugna pacos), the guanaco (Lama guanicoe), and the vicuña (Vicugna vicugna). These animals are characterized by their long necks, long legs, and a pad on their chest instead of a true knee joint. They are known for their ability to survive in harsh environments with limited water and food resources.
Sleep stages are distinct patterns of brain activity that occur during sleep, as measured by an electroencephalogram (EEG). They are part of the sleep cycle and are used to describe the different types of sleep that humans go through during a normal night's rest. The sleep cycle includes several repeating stages:
1. Stage 1 (N1): This is the lightest stage of sleep, where you transition from wakefulness to sleep. During this stage, muscle activity and brain waves begin to slow down.
2. Stage 2 (N2): In this stage, your heart rate slows, body temperature decreases, and eye movements stop. Brain wave activity becomes slower, with occasional bursts of electrical activity called sleep spindles.
3. Stage 3 (N3): Also known as deep non-REM sleep, this stage is characterized by slow delta waves. It is during this stage that the body undergoes restorative processes such as tissue repair, growth, and immune function enhancement.
4. REM (Rapid Eye Movement) sleep: This is the stage where dreaming typically occurs. Your eyes move rapidly beneath closed eyelids, heart rate and respiration become irregular, and brain wave activity increases to levels similar to wakefulness. REM sleep is important for memory consolidation and learning.
The sleep cycle progresses through these stages multiple times during the night, with REM sleep periods becoming longer towards morning. Understanding sleep stages is crucial in diagnosing and treating various sleep disorders.
'Infant behavior' is not a medical term per se, but it does fall under the purview of child development and pediatrics. It generally refers to the actions or reactions of an infant (a child between birth and 12 months) in response to internal states (e.g., hunger, discomfort, fatigue) and external stimuli (e.g., people, objects, events).
Infant behavior can encompass a wide range of aspects including:
1. Reflexes: Automatic responses to certain stimuli, such as the rooting reflex (turning head towards touch on cheek) or startle reflex (abrupt muscle contraction).
2. Motor skills: Control and coordination of movements, from simple ones like lifting the head to complex ones like crawling.
3. Social-emotional development: Responses to social interactions, forming attachments, expressing emotions.
4. Communication: Using cries, coos, gestures, and later, words to communicate needs and feelings.
5. Cognitive development: Problem-solving skills, memory, attention, and perception.
Understanding typical infant behavior is crucial for parental education, childcare, early intervention when there are concerns, and overall child development research.
I understand you are asking for a medical definition of "Horse Diseases." However, it's important to note that there isn't a specific medical field dedicated to horse diseases as we typically categorize medical fields by human diseases and conditions. Veterinary medicine is the field responsible for studying, diagnosing, and treating diseases in animals, including horses.
Here's a general definition of 'Horse Diseases':
Horse diseases are health issues or medical conditions that affect equine species, particularly horses. These diseases can be caused by various factors such as bacterial, viral, fungal, or parasitic infections; genetic predispositions; environmental factors; and metabolic disorders. Examples of horse diseases include Strangles (Streptococcus equi), Equine Influenza, Equine Herpesvirus, West Nile Virus, Rabies, Potomac Horse Fever, Lyme Disease, and internal or external parasites like worms and ticks. Additionally, horses can suffer from musculoskeletal disorders such as arthritis, laminitis, and various injuries. Regular veterinary care, preventative measures, and proper management are crucial for maintaining horse health and preventing diseases.
Aminoglutethimide is a medication that is primarily used to treat hormone-sensitive cancers such as breast cancer and prostate cancer. It works by blocking the production of certain hormones in the body, including estrogen and cortisol. Aminoglutethimide is an inhibitor of steroid synthesis, specifically targeting the enzymes involved in the conversion of cholesterol to steroid hormones.
The medication is available in oral form and is typically taken 2-3 times a day. Common side effects include drowsiness, dizziness, dry mouth, skin rash, and changes in appetite or weight. More serious side effects may include liver damage, severe allergic reactions, and changes in heart rhythm.
It's important to note that aminoglutethimide can interact with other medications, so it's crucial to inform your healthcare provider about all the drugs you are currently taking before starting this medication. Additionally, regular monitoring of liver function and hormone levels may be necessary during treatment with aminoglutethimide.
Carcinogenicity tests are a type of toxicity test used to determine the potential of a chemical or physical agent to cause cancer. These tests are typically conducted on animals, such as rats or mice, and involve exposing the animals to the agent over a long period of time, often for the majority of their lifespan. The animals are then closely monitored for any signs of tumor development or other indicators of cancer.
The results of carcinogenicity tests can be used by regulatory agencies, such as the U.S. Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA), to help determine safe exposure levels for chemicals and other agents. The tests are also used by industry to assess the potential health risks associated with their products and to develop safer alternatives.
It is important to note that carcinogenicity tests have limitations, including the use of animals, which may not always accurately predict the effects of a chemical on humans. Additionally, these tests can be time-consuming and expensive, which has led to the development of alternative test methods, such as in vitro (test tube) assays and computational models, that aim to provide more efficient and ethical alternatives for carcinogenicity testing.
Vomiting is defined in medical terms as the forceful expulsion of stomach contents through the mouth. It is a violent, involuntary act that is usually accompanied by strong contractions of the abdominal muscles and retching. The body's vomiting reflex is typically triggered when the brain receives signals from the digestive system that something is amiss.
There are many potential causes of vomiting, including gastrointestinal infections, food poisoning, motion sickness, pregnancy, alcohol consumption, and certain medications or medical conditions. In some cases, vomiting can be a symptom of a more serious underlying condition, such as a brain injury, concussion, or chemical imbalance in the body.
Vomiting is generally not considered a serious medical emergency on its own, but it can lead to dehydration and other complications if left untreated. If vomiting persists for an extended period of time, or if it is accompanied by other concerning symptoms such as severe abdominal pain, fever, or difficulty breathing, it is important to seek medical attention promptly.
Fever, also known as pyrexia or febrile response, is a common medical sign characterized by an elevation in core body temperature above the normal range of 36.5-37.5°C (97.7-99.5°F) due to a dysregulation of the body's thermoregulatory system. It is often a response to an infection, inflammation, or other underlying medical conditions, and it serves as a part of the immune system's effort to combat the invading pathogens or to repair damaged tissues.
Fevers can be classified based on their magnitude:
* Low-grade fever: 37.5-38°C (99.5-100.4°F)
* Moderate fever: 38-39°C (100.4-102.2°F)
* High-grade or severe fever: above 39°C (102.2°F)
It is important to note that a single elevated temperature reading does not necessarily indicate the presence of a fever, as body temperature can fluctuate throughout the day and can be influenced by various factors such as physical activity, environmental conditions, and the menstrual cycle in females. The diagnosis of fever typically requires the confirmation of an elevated core body temperature on at least two occasions or a consistently high temperature over a period of time.
While fevers are generally considered beneficial in fighting off infections and promoting recovery, extremely high temperatures or prolonged febrile states may necessitate medical intervention to prevent potential complications such as dehydration, seizures, or damage to vital organs.
"Cat" is a common name that refers to various species of small carnivorous mammals that belong to the family Felidae. The domestic cat, also known as Felis catus or Felis silvestris catus, is a popular pet and companion animal. It is a subspecies of the wildcat, which is found in Europe, Africa, and Asia.
Domestic cats are often kept as pets because of their companionship, playful behavior, and ability to hunt vermin. They are also valued for their ability to provide emotional support and therapy to people. Cats are obligate carnivores, which means that they require a diet that consists mainly of meat to meet their nutritional needs.
Cats are known for their agility, sharp senses, and predatory instincts. They have retractable claws, which they use for hunting and self-defense. Cats also have a keen sense of smell, hearing, and vision, which allow them to detect prey and navigate their environment.
In medical terms, cats can be hosts to various parasites and diseases that can affect humans and other animals. Some common feline diseases include rabies, feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and toxoplasmosis. It is important for cat owners to keep their pets healthy and up-to-date on vaccinations and preventative treatments to protect both the cats and their human companions.
F344 is a strain code used to designate an outbred stock of rats that has been inbreeded for over 100 generations. The F344 rats, also known as Fischer 344 rats, were originally developed at the National Institutes of Health (NIH) and are now widely used in biomedical research due to their consistent and reliable genetic background.
Inbred strains, like the F344, are created by mating genetically identical individuals (siblings or parents and offspring) for many generations until a state of complete homozygosity is reached, meaning that all members of the strain have identical genomes. This genetic uniformity makes inbred strains ideal for use in studies where consistent and reproducible results are important.
F344 rats are known for their longevity, with a median lifespan of around 27-31 months, making them useful for aging research. They also have a relatively low incidence of spontaneous tumors compared to other rat strains. However, they may be more susceptible to certain types of cancer and other diseases due to their inbred status.
It's important to note that while F344 rats are often used as a standard laboratory rat strain, there can still be some genetic variation between individual animals within the same strain, particularly if they come from different suppliers or breeding colonies. Therefore, it's always important to consider the source and history of any animal model when designing experiments and interpreting results.
Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.
Boredom is not a medical condition or diagnosis that appears in the standard classifications used by healthcare professionals. It is a common human experience that can be described as a feeling of dissatisfaction, restlessness, and lack of interest in one's current situation or activities. Boredom can stem from various factors such as monotony, lack of stimulation, or unmet psychological needs.
While not a medical condition itself, boredom can sometimes contribute to mental health issues like anxiety, depression, or poor impulse control. If you find that boredom frequently leads to negative emotions or behaviors, it might be helpful to consult a mental health professional for guidance on how to better manage your feelings and engage in more fulfilling activities.
Postencephalitic Parkinson's disease (PEPD) is a secondary form of Parkinsonism that occurs as a result of viral encephalitis, most commonly following the 1918-1920 influenza pandemic. It is a rare condition today due to advancements in healthcare and vaccinations.
The infection causes inflammation in the brain, leading to damage in various areas, particularly the substantia nigra pars compacta, where dopamine-producing neurons are located. This results in decreased levels of dopamine, a neurotransmitter essential for smooth and controlled muscle movements.
The symptoms of PEPD can be similar to those seen in primary Parkinson's disease (PD), such as bradykinesia (slowness of movement), rigidity, resting tremors, and postural instability. However, there are some distinct differences between the two conditions:
1. Age at onset: PEPD tends to affect younger individuals, often in their 20s or 30s, while primary PD usually manifests in people over 50.
2. Symptom progression: The progression of symptoms in PEPD is typically more rapid and severe than in primary PD.
3. Non-motor symptoms: PEPD often presents with a wider range of non-motor symptoms, including sleep disturbances, mood changes, autonomic dysfunction, and oculogyric crises (involuntary upward deviation of the eyes).
4. Response to treatment: PEPD may not respond as well to levodopa therapy compared to primary PD, and patients often experience more severe side effects such as dyskinesias (abnormal involuntary movements) and motor fluctuations.
It is essential to differentiate between postencephalitic Parkinson's disease and primary Parkinson's disease, as the treatment approaches and prognosis may differ significantly.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Sleep is a complex physiological process characterized by altered consciousness, relatively inhibited sensory activity, reduced voluntary muscle activity, and decreased interaction with the environment. It's typically associated with specific stages that can be identified through electroencephalography (EEG) patterns. These stages include rapid eye movement (REM) sleep, associated with dreaming, and non-rapid eye movement (NREM) sleep, which is further divided into three stages.
Sleep serves a variety of functions, including restoration and strengthening of the immune system, support for growth and development in children and adolescents, consolidation of memory, learning, and emotional regulation. The lack of sufficient sleep or poor quality sleep can lead to significant health problems, such as obesity, diabetes, cardiovascular disease, and even cognitive decline.
The American Academy of Sleep Medicine (AASM) defines sleep as "a period of daily recurring natural rest during which consciousness is suspended and metabolic processes are reduced." However, it's important to note that the exact mechanisms and purposes of sleep are still being researched and debated among scientists.
Physiology is the scientific study of the normal functions and mechanisms of living organisms, including all of their biological systems, organs, cells, and biomolecules. It focuses on how various bodily functions are regulated, coordinated, and integrated to maintain a healthy state in an organism. This field encompasses a wide range of areas such as cellular physiology, neurophysiology, cardiovascular physiology, respiratory physiology, renal physiology, endocrine physiology, reproductive physiology, and exercise physiology, among others. Physiologists use a combination of experimental and theoretical approaches to understand the principles underlying normal biological function and to investigate how these functions are altered in various disease states.
Sleep deprivation is a condition that occurs when an individual fails to get sufficient quality sleep or the recommended amount of sleep, typically 7-9 hours for adults. This can lead to various physical and mental health issues. It can be acute, lasting for one night or a few days, or chronic, persisting over a longer period.
The consequences of sleep deprivation include:
1. Fatigue and lack of energy
2. Difficulty concentrating or remembering things
3. Mood changes, such as irritability or depression
4. Weakened immune system
5. Increased appetite and potential weight gain
6. Higher risk of accidents due to decreased reaction time
7. Health problems like high blood pressure, diabetes, and heart disease over time
Sleep deprivation can be caused by various factors, including stress, shift work, sleep disorders like insomnia or sleep apnea, poor sleep hygiene, and certain medications. It's essential to address the underlying causes of sleep deprivation to ensure proper rest and overall well-being.
Lethargy
Lethargy (film)
Lethargy theorem
Lethargy (band)
Springtime lethargy
Six Lethargies
Idiopathic chronic fatigue
Procarbazine
Brann Dailor
Three Violent People
Shibuya incident
Dan Haigh
Indian Squash Academy
1994 Idaho Vandals football team
Fenfluramine
List of poems by Ivan Bunin
1955 Atlantic hurricane season
Jorge Costa
David Bruce (microbiologist)
Casey Tiumalu
Bak Solmay
Malignant peripheral nerve sheath tumor
Sleeping Sickness Commission
Lifted Research Group
Steve McManaman
Glycerol kinase deficiency
Death (tarot card)
Scurvy
Mycoplasma haemofelis
The Fortune
Lethargy - Wikipedia
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- Healthline - What Causes Lethargy? (britannica.com)
- What Causes Lethargy in Dogs? (getvetco.com)
- Lack of water in the body also causes lethargy, due to which one does not feel like doing any work. (besmartguru.com)
Symptoms8
- BBC Food Article: www.bbc.co.uk/food/articles/mineral_deficiency Many people in the UK are not getting the recommended amount of some vital minerals, leading to symptoms including fatigue and lethargy, sometimes with long-term health risks. (betterbiohealth.com)
- But, if you are in the sun for too long, it can dehydrate your body and bring about symptoms of lethargy. (dianepenelope.com)
- However, some dogs may exhibit symptoms of lethargy after a flea treatment. (bestiepaws.com)
- Apart from lethargy, a dog might exhibit other symptoms after a flea treatment. (bestiepaws.com)
- Sometimes, lethargy is accompanied by visible physical symptoms. (somegrub.co.uk)
- Lethargy is accompanied by other concerning symptoms like vomiting, diarrhoea, or difficulty breathing. (somegrub.co.uk)
- Monitor and seek medical advice - If there are notable symptoms in addition to the lethargy, it is even more important to seek the advice of a vet sooner rather than later. (getvetco.com)
- Yogurt contains proteins, carbohydrates, which remove the symptoms of lethargy and fatigue. (besmartguru.com)
Lasting drowsiness1
- lethargy , in medicine , a morbid condition of deep and lasting drowsiness from which the sufferer can be aroused only with difficulty and temporarily. (britannica.com)
Apathy3
- Far from being a state of apathy, however, lethargy may hold the potential for social change. (penguinrandomhouse.com)
- Now as never before should you strive mightily to free yourselves from the obstacles of apathy, attachment to worldly pursuits, and lethargy, which stand in the way of so glorious a realization. (bahaiteachings.org)
- However, to accomplish these noble goals everyone must overcome two major hurdles: apathy and lethargy. (bahaiteachings.org)
Fatigue4
- The words lassitude and lethargy can be used in similar contexts, but lassitude stresses listlessness or indifference resulting from fatigue or poor health. (merriam-webster.com)
- Unstable blood sugar levels, food intolerances, diabetes and chronic fatigue syndrome may all be causes of lethargy. (hypnosisdownloads.com)
- Below is the change in Fatigue / Lethargy / Tiredness seen after the predictor is higher than average. (quantimo.do)
- Fatigue, weakness and lethargy are common in the body due to lack of energy and lack of sleep. (besmartguru.com)
Sluggishness1
- Lethargy is a state where a dog shows noticeable sluggishness, indifference, and decreased energy levels. (somegrub.co.uk)
Laziness2
- Duration: Lethargy lasts for extended periods, while laziness can be sporadic. (somegrub.co.uk)
- Behavioural changes: Lethargy often comes with other behavioural changes, whereas laziness does not. (somegrub.co.uk)
Weakness1
- When a dog reacts this way, it can often manifest as lethargy, a lack of energy, or general weakness. (bestiepaws.com)
Symptom2
- As mentioned earlier, lethargy is a symptom associated with many underlying medical conditions. (stylecraze.com)
- Lethargy is a common symptom for a variety of conditions, especially in older dogs. (getvetco.com)
Noun1
- How does the noun lethargy contrast with its synonyms? (merriam-webster.com)
Duration1
- The duration of lethargy can vary depending on the individual dog and their reaction to the treatment. (bestiepaws.com)
Loss of appet3
- Unexplained limp, lethargy and loss of appetite. (pets.ca)
- A sudden loss of appetite accompanied by lethargy could be indicative of digestive issues, dental problems, or more severe conditions. (somegrub.co.uk)
- Sometimes, anxiety or stress can cause lethargy, in which case it is commonly accompanied by social withdrawal and a loss of appetite. (getvetco.com)
Excessive1
- However, there's a fine line between healthy rest and excessive lethargy. (somegrub.co.uk)
Dog's1
- It's essential to know when to consult a professional about your dog's lethargy. (somegrub.co.uk)
Listlessness2
- Tung-Hui Hu calls this state of exhaustion, disappointment, and listlessness digital lethargy . (penguinrandomhouse.com)
- This article looks at some of the remedies and foods that can treat lethargy naturally and curb the feeling of listlessness and lassitude. (stylecraze.com)
Boredom1
- If boredom is twinned with lethargy then pessimism is a first cousin. (hypnosisdownloads.com)
Depression2
- There is no 'gene for lethargy' (just as there is no gene for depression ) but attitudes can be passed from one person to another like an infection. (hypnosisdownloads.com)
- The physician may also order a psychiatric assessment to rule out depression as a cause for lethargy and disorientation. (medscape.com)
Lassitude2
- Some common synonyms of lethargy are languor , lassitude , stupor , and torpor . (merriam-webster.com)
- When is lassitude a more appropriate choice than lethargy ? (merriam-webster.com)
Https2
- Merriam-Webster.com Thesaurus , Merriam-Webster, https://www.merriam-webster.com/thesaurus/lethargy. (merriam-webster.com)
- 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/427235/all/Lethargy__grunting__and_hypercapnia_predict_ventilator_risk_in_kids_with_RSV. (unboundmedicine.com)
Consult1
- Here are some of the most common reasons for lethargy in dogs, as well as some natural remedy suggestions and supplements , and how to know when it's time to consult your vet. (getvetco.com)
Motivation2
- Lethargy robs you of motivation and without motivation you do nothing. (hypnosisdownloads.com)
- This relaxing hypnotic session seeks to lift lethargy and give you a shot of motivation and compulsion to act and work. (hypnosisdownloads.com)
Occasional1
- While occasional restfulness is natural, prolonged or sudden lethargy should not be overlooked. (somegrub.co.uk)
Condition2
- Lethargy is a common condition associated with many medical issues, which leaves an individual feeling sleepy and fatigued (both mental and physical). (stylecraze.com)
- Arthritis can also create lethargy and is a condition most prevalent in older dogs. (getvetco.com)
Mental1
- While all these words mean "physical or mental inertness," lethargy implies such drowsiness or aversion to activity as is induced by disease, injury, or drugs. (merriam-webster.com)
Good1
- When would languor be a good substitute for lethargy ? (merriam-webster.com)
Common1
- Although the words stupor and lethargy have much in common, stupor implies a deadening of the mind and senses by shock, narcotics, or intoxicants. (merriam-webster.com)
Feel2
- But if you feel your lethargy has just become a habit and it's now automatic for you to respond to a call to action with a: 'What's the point? (hypnosisdownloads.com)
- Lethargy makes you feel very sluggish , tired and yet, you can't get to sleep properly. (dianepenelope.com)
Health1
- Lethargy can be a sign of many different health problems, including pancreatitis. (everycreaturecounts.org)
Conditions1
- Surprisingly, an increased appetite combined with lethargy might point to conditions like diabetes. (somegrub.co.uk)
Alternative1
- Where would stupor be a reasonable alternative to lethargy ? (merriam-webster.com)
Maximum1
- This means that as a long-term strategy and it's ideal in that you can maintain Trenbolone as Trenbolone (and testosterone) in excess of the anabolic (androgenic) and thus Trenbolone level stays high and allows for maximum testosterone synthesis, trenbolone lethargy. (makingrealmovesllc.com)
Normal1
- Understanding the difference between normal restfulness and concerning lethargy is the first step. (somegrub.co.uk)