Contribution of vascular pathology to the clinical expression of dementia. (1/181)
(+info)Stroke risk modifies regional white matter differences in mild cognitive impairment. (2/181)
(+info)The experimental induction of leukoencephalomyelopathy in cats. (3/181)
(+info)Analysis of genetic variability and whole genome linkage of whole-brain, subcortical, and ependymal hyperintense white matter volume. (4/181)
(+info)Higher systolic blood pressure is associated with increased water diffusivity in normal-appearing white matter. (5/181)
(+info)Methadone-induced toxic leukoencephalopathy: MR imaging and MR proton spectroscopy findings. (6/181)
(+info)Reversible delayed leukoencephalopathy after heroin intoxication with hypoxia: a case report. (7/181)
Delayed neurological deterioration after hypoxia is uncommon. Here we report a case of reversible delayed leukoencephalopathy following intravenous heroin intoxication with hypoxia. A 42-year-old man presented disturbed consciousness and unstable hemodynamic status after intravenous heroin injection. He made a good initial recovery after infection control and hemodynamic support. But his neurological condition deteriorated later on and gradually progressed into akinetic mutism and generalized hypertonia within 3 weeks. Prominent leukoencephalopathy was disclosed by magnetic resonance imaging (MRI) of the brain. His general condition improved again in a few months and follow-up MRI revealed regression of the white matter lesion. Early diagnosis of delayed leukoencephalopathy with appropriate supportive treatment may be worthwhile as illustrated by the reported case. (+info)Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (8/181)
(+info)Leukoencephalopathies are a group of medical conditions that primarily affect the white matter of the brain, which consists mainly of nerve fibers covered by myelin sheaths. These conditions are characterized by abnormalities in the structure and function of the white matter, leading to various neurological symptoms such as cognitive decline, motor impairment, seizures, and behavioral changes.
The term "leukoencephalopathy" is derived from two Greek words: "leukos," meaning white, and "enkephalos," meaning brain. The suffix "-pathy" refers to a disease or suffering. Therefore, leukoencephalopathies refer specifically to diseases that affect the white matter of the brain.
There are various types of leukoencephalopathies, including genetic, metabolic, infectious, toxic, and immune-mediated forms. Some examples include multiple sclerosis, adrenoleukodystrophy, Alexander disease, Canavan disease, and Marchiafava-Bignami disease. The diagnosis of leukoencephalopathies typically involves a combination of clinical evaluation, imaging studies such as MRI, and sometimes genetic or laboratory testing to identify the underlying cause. Treatment depends on the specific type and severity of the condition and may include medications, dietary modifications, physical therapy, or supportive care.