A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a "leather bottle" shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach.
Tumors or cancer of the STOMACH.

Primary linitis plastica of the rectosigmoid in a thirteen year old boy. (1/14)

Childhood malignant neoplasms of the gut are extremely rare. The reported incidence of colorectal cancers in patients under 20 years of age is 1 in 10 million. The low index of suspicion for this tumour in children results in advanced disease at diagnosis and subsequently a poor prognosis. A rare case of a primary linitis plastica of the rectum occurring in a 13 year old boy is reported with review of pertinent literature.  (+info)

Marked increase of trypsin(ogen) in serum of linitis plastica (gastric cancer, borrmann 4) patients. (2/14)

Linitis plastica, or Borrmann 4 gastric cancer, shows very poor prognosis, and the reason has not been understood. In the present study, we examined serum levels of trypsin(ogen) in 44 gastric cancer patients, including 17 early gastric cancer, 18 non-Borrmann 4 advanced gastric cancer, and 9 Borrmann 4 gastric cancer, by using the RIA gnost Trypsin kit (Hoechst Japan, Tokyo, Japan), which was expected to detect trypsin-1, trypsin-2, trypsinogen-1, and trypsinogen-2 in sera. The trypsin(ogen) concentration was much higher in the patients with linitis plastica than in the other gross types of gastric cancer. Hypertrypsinemia was identified in approximately 60% of advanced gastric cancer cases. Lymph node involvement, liver metastasis, or poorly differentiated adenocarcinoma is an important factor of hypertrypsinemia. The serum trypsin(ogen) level in linitis plastica patients was 3484.4 +/- 2319.7 ng/ml (mean +/- SD), which was significantly higher not only than that of the early gastric cancer (384.1 +/- 92.1) but also the stage IV gastric cancer patients (578 +/- 440.4), excluding those with linitis plastica. The elevated serum trypsinogen level in linitis plastica patients may be related to the malignant behavior of this type of cancer cell. Serum trypsin(ogen) of linitis plastica shows significantly higher concentrations than do the other types of advanced gastric cancer. Therefore, serum concentration of trypsin(ogen) might be a good marker of gastric cancer of linitis plastica.  (+info)

Gastric linitis adenocarcinoma and carcinomatous meningitis: an infrequent but aggressive association--report of four cases. (3/14)

Carcinomatous meningitis (CM) is a very rare complication of gastrointestinal malignancies and especially gastric adenocarcinoma. Linitis plastica (LP), which is a specific form of gastric neoplasia, locally penetrates through the gastric wall to reach the peritoneum. Lymph node involvement is frequent and metastatic sites are almost exclusively observed in the abdominal cavity. The meningeal localization is extremely rare with only a few cases described in the literature. We report here, over a five-year period, four cases of CM on a total of eighty linitis cases diagnosed and treated in our institution, which represent 5% of a non selected linitis population. The clinical manifestations were clearly poor, and characterized by aspecific neurological signs. The diagnosis was made by the discovery of signet cells in the cerebrospinal fluid. Invasive treatment, consisting of intrathecal infusion of chemotherapy, was undertaken with mixed clinical response and no cytological normalization of the cerebrospinal fluid (CSF). In conclusion, our observation which is based on a large series of successive gastric linitis, demonstrates a 5% frequency of developing CM with a predominance among metastatic patients. Furthermore, the diagnosis of CM must be done as soon as possible because of the clear effectiveness of a therapeutic approach on the improvement of symptoms and quality of life.  (+info)

A case of linitis plastica involving the entire colon, ileum, and appendix. (4/14)

Linitis plastica of the colon is an uncommon presentation of primary colorectal cancer. This entity of colorectal cancer is characterized by a diffuse infiltrating tumor with desmoplastic reaction and poor prognosis. Although widespread infiltration is the main feature of linitis plastica, the tumor extending to more than 2 segments of the colon is uncommon. We report a case of primary linitis plastica involving the entire colon, ileum and appendix. The clinical characteristics are discussed with a review of literatures.  (+info)

Detection of disseminated cancer cells in linitis plastica-type gastric carcinoma. (5/14)

BACKGROUND: Dissemination of cancer cells in the abdominal cavity may lead to peritoneal carcinomatosis, a common event in the linitis plastica type of gastric carcinoma. Reverse transcriptase polymerase chain reaction (RT-PCR) is a sensitive technique for detecting these cells. METHODS: Peritoneal washings were obtained during laparotomy from 47 consecutive linitis plastica patients who preoperatively were considered candidates for curative resection. Together with conventional cytological examination using Papanicolaou staining, real-time RT-PCR was performed to quantitate prospectively carcinoembryonic antigen (CEA) mRNA in these washings. Samples above a cutoff value for CEA mRNA were considered positive for molecular detection of disseminated cancer cells. RESULTS: Conventional cytological examination was positive in 43% (20/47). Positivity of CEA mRNA was much higher at 83% (39/47) and peritoneal carcinomatosis actually was observed in 77% (36/47), either at laparotomy or during postoperative follow-up. Although only two of eight patients who were negative for CEA mRNA suffered from peritoneal carcinomatosis, three more patients died of recurrences through other metastatic pathways. Multivariate analysis revealed that curability of the operation (knowledge of the CEA mRNA values excluded) and T categories were the only significant independent prognostic factors. CONCLUSIONS: RT-PCR of the peritoneal washes had little value as a prognostic factor, but identified over 80% of the patients planned for curative surgery to have disseminated cancer cells in the peritoneal cavity. Almost the same proportion of patients actually suffered from peritoneal carcinomatosis. These facts indicate why treatment with surgery alone rarely cures patients with linitis plastica.  (+info)

Different regression equations relate age to the incidence of Lauren types 1 and 2 stomach cancer in the SEER database: these equations are unaffected by sex or race. (6/14)

BACKGROUND: Although impacts upon gastric cancer incidence of race, age, sex, and Lauren type have been individually explored, neither their importance when evaluated together nor the presence or absence of interactions among them have not been fully described. METHODS: This study, derived from SEER (Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute) data, analyzed the incidences of gastric cancer between the years 1992-2001. There were 7882 patients who had developed gastric cancer. The total denominator population was 145,155, 669 persons (68,395,787 for 1992-1996, 78,759,882 for 1997-2001). Patients with multiple tumors were evaluated as per the default of the SEER*Stat program. 160 age-, five year period (1992-1996 vs 1997-2001)-, sex-, race (Asian vs non-Asian)-, Lauren type- specific incidences were derived to form the stratified sample evaluated by linear regression. (160 groups = 2 five year periods x 2 race groups x 2 sexes x 2 Lauren types x 10 age groups.) Linear regression was used to analyze the importance of each of these explanatory variables and to see if there were interactions among the explanatory variables. RESULTS: Race, sex, age group, and Lauren type were found to be important explanatory variables, as were interactions between Lauren type and each of the other important explanatory variables. In the final model, the contribution of each explanatory variable was highly statistically significant (t > 5, d.f. 151, P < 0.00001). The regression equation for Lauren type 1 had different coefficients for the explanatory variables Race, Sex, and Age, than did the regression equation for Lauren type 2. CONCLUSION: The change of the incidence of stomach cancer with respect to age for Lauren type 1 stomach cancer differs from that for Lauren type 2 stomach cancers. The relationships between age and Lauren type do not differ across gender or race. The results support the notion that Lauren type 1 and Lauren type 2 gastric cancers have different etiologies and different patterns of progression from pre-cancer to cancer. The results should be validated by evaluation of other databases.  (+info)

An endoscopic view in gastric linitis. A case report. (7/14)

A case of an 84 year old woman addressed for dysphagia is discussed. The endoscopic and histologic examination revealed a gastric linitis with cardial invasion. Classically, there is no characteristic macroscopic description associated with gastric linitis. An endoscopic aspect considered highly suggestive for gastric linitis is presented.  (+info)

Subsite distribution of gastric cancer in an area of high prevalence--northwest Iran. (8/14)

BACKGROUND: The aim of the present study was to determine subsites of gastric cancer in East Azerbaijan, Iran-a high incidence region for gastric cancer and Helicobacter pylori infection. METHODS: Data were collected from 2002 through 2007 from patients who sought treatment for gastrointestinal symptoms or signs at a university clinic and subsequently underwent upper gastrointestinal endoscopy. RESULTS: Cancer was diagnosed and histologically confirmed in 362 patients (352 adenocarcinomas). The mean age of the patients was 64.57 +/- 11.32 (range, 16-94 years) and the male-to-female ratio was 2.8:1. The gastric cardia was involved in 40.3% of patients with gastric adenocarcinoma, while the gastric fundus was involved in 3.7%, the gastric body in 49.1%, and the gastric antrum in 24.1% of patients. Complete evaluation for metastasis was possible in 144 patients; 61 were free of metastasis, and most of these patients underwent surgical therapy. Cardia involvement was not associated with the sex or age of patients. CONCLUSIONS: Noncardia gastric cancer is still more frequent in East Azerbaijan, which is likely due to the very high prevalence of infection with Helicobacter pylori. The low rate of cancer involving the fundus is a target for further research on the etiology of gastric cancer.  (+info)

Linitis plastica is a pathological term that describes a condition in which the wall of an organ, most commonly the stomach, becomes thickened and stiff due to the growth of cancerous cells within the wall's submucosa and muscularis propria layers. This infiltration of malignant cells gives the organ's wall a characteristic "leather-bottle" or "pipe-stem" appearance, which is where the term "linitis plastica" originates from - "linitis" meaning "leather-like," and "plastica" meaning "formation."

This condition most frequently occurs in association with diffuse (signet-ring cell) gastric adenocarcinoma, a specific subtype of stomach cancer. The infiltrative growth pattern of these cancer cells leads to the replacement of normal tissue structure with dense tumor cell deposits, causing the organ's wall to thicken and lose its elasticity.

Linitis plastica can also rarely affect other organs, such as the urinary bladder, biliary system, or large intestine. The condition is often associated with poor prognosis due to its advanced stage at diagnosis and the difficulty of achieving complete surgical resection.

Stomach neoplasms refer to abnormal growths in the stomach that can be benign or malignant. They include a wide range of conditions such as:

1. Gastric adenomas: These are benign tumors that develop from glandular cells in the stomach lining.
2. Gastrointestinal stromal tumors (GISTs): These are rare tumors that can be found in the stomach and other parts of the digestive tract. They originate from the stem cells in the wall of the digestive tract.
3. Leiomyomas: These are benign tumors that develop from smooth muscle cells in the stomach wall.
4. Lipomas: These are benign tumors that develop from fat cells in the stomach wall.
5. Neuroendocrine tumors (NETs): These are tumors that develop from the neuroendocrine cells in the stomach lining. They can be benign or malignant.
6. Gastric carcinomas: These are malignant tumors that develop from the glandular cells in the stomach lining. They are the most common type of stomach neoplasm and include adenocarcinomas, signet ring cell carcinomas, and others.
7. Lymphomas: These are malignant tumors that develop from the immune cells in the stomach wall.

Stomach neoplasms can cause various symptoms such as abdominal pain, nausea, vomiting, weight loss, and difficulty swallowing. The diagnosis of stomach neoplasms usually involves a combination of imaging tests, endoscopy, and biopsy. Treatment options depend on the type and stage of the neoplasm and may include surgery, chemotherapy, radiation therapy, or targeted therapy.

... is a type of adenocarcinoma and accounts for 3-19% of gastric adenocarcinomas. Causes of cancerous linitis ... Linitis plastica is a widely used term for Brinton's disease (also known as leather bottle stomach), a morphological variant of ... Symptoms of linitis plastica do not usually present until the disease is in an advanced stage, making early diagnosis difficult ... Wikimedia Commons has media related to Linitis plastica. "Carcinoma of the Stomach." at patient.info (CS1 maint: multiple names ...
Mikio Narita, 55, Japanese actor, linitis plastica. Chips Sobek, 70, American basketball player. Astrid Sommer, 83, Norwegian ...
He also portrayed the evil character in Mito Kōmon (3rd season). He died of Linitis plastica on 9 April 1990. His final film ...
He died of linitis plastica on December 25, 1993, at the age of 48. Itsumi, Masataka; Itsumi, Harue Gan Saihatsusu (ガン再発す) ( ...
Patients with higher CMTM2 levels in their linitis plastica stomach cancer (i.e. a type of gastric cancer also termed diffuse- ... tissues had better prognoses than patients with lower CMTM2 levels in their linitis plastica tissues. And, the CMTM2 gene has ... suggest that the CMTM2 gene may act as a tumor suppressor not only in hepatocellular carcinoma but also in linitis plastica and ...
Linitis plastica (C16._) M8143/3 Superficial spreading adenocarcinoma M8144/3 Adenocarcinoma, intestinal type (C16._) Carcinoma ...
... linitis plastica MeSH C04.557.470.200.025.105 - adenocarcinoma, sebaceous MeSH C04.557.470.200.025.152 - adrenocortical ...
Linitis plastica (M8155/3) Vipoma (M8160/3) Cholangiocarcinoma (M8170/3) Hepatocellular carcinoma, NOS (M8200/3) Adenoid cystic ...
Diffuse type adenocarcinoma (mucinous, colloid, linitis plastica or leather-bottle stomach) tumour cells are discohesive and ...
Malignant Tumours of the stomach, including adenocarcinoma (and its linitis plastica variant), lymphoma, and gastrointestinal ...
Linitis plastica is a type of adenocarcinoma and accounts for 3-19% of gastric adenocarcinomas. Causes of cancerous linitis ... Linitis plastica is a widely used term for Brintons disease (also known as leather bottle stomach), a morphological variant of ... Symptoms of linitis plastica do not usually present until the disease is in an advanced stage, making early diagnosis difficult ... Wikimedia Commons has media related to Linitis plastica. "Carcinoma of the Stomach." at patient.info (CS1 maint: multiple names ...
I have avery close friend who has recently been diagnosed with linitis plastica. It is inoperable and stage four. He is very ... Linitis Plastica Hereditary?. Hey, My husband, age 50 diagnosed at end of April 2009 with a cancer, not linitis plastica until ... Linitis Plastica Hereditary?. Hey, My husband, age 50 diagnosed at end of April 2009 with a cancer, not linitis plastica until ... Linitis Plastica Survivor. I was diagnosed on 8/7/2008 with linitis plastica gastric cancer at the age of 39. My tumor was ...
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica Zhu Liu # 1 , Lian-Lian ... Linitis Plastica: a Distinct Type of Gastric Cancer. Ikoma N, Agnes A, Chen HC, Wang X, Blum MM, Das P, Minsky B, Estrella JS, ... Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica Zhu Liu et al. Gastric ... The significance of a nineteenth century definition in the era of genomics: linitis plastica. Agnes A, Estrella JS, Badgwell B. ...
Although linitis plastica is usually caused by gastric carcinoma, it can also be caused by metastatic breast cancer. ... giving rise to the typical linitis plastica, or "leather bottle," appearance (as seen in the image below). Although some are ...
Extensive gastric involvement may resemble linitis plastica.. Endoscopic findings in lymphocytic gastritis include enlarged ...
6. Linitis Plastica: a Distinct Type of Gastric Cancer.. Ikoma N; Agnes A; Chen HC; Wang X; Blum MM; Das P; Minsky B; Estrella ... Linitis plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass: a case report.. Haenen FW; Gys B; Moreels T; ... 2. [Linitis plastica].. Issam Beyrouti M; Beyrouti R; Ben Amar M; Frikha F; Beyrouti R; Abid M; Ben Salah K; Boujelben S. ... 5. Linitis plastica in a child.. Black RE. J Pediatr Surg; 1985 Feb; 20(1):86-7. PubMed ID: 2983060. [TBL] ...
Figure 2. Endoscopic image of diffuse gastric cancer with typical linitis plastica involvement. This occurs at an advanced ...
These tumours characteristically have infiltrative submucosal growth patterns resembling linitis plastica of the stomach. On ...
A clinical lecture on linitis plastica, or leather bottle stomach.. Subject(s):. Stomach (Inflammation of, Hypertrophic) [ ... A case of linitis plastica.. Subject(s):. Stomach (Inflammation of, Hypertrophic) [ Linitis plastica ]. ...
In a large linitis plastica cohort study in the National Cancer Database, 51.9% of cases occurred in females and 48.1% occurred ... Linitis plastica is a malignant tumor that causes local gastric infiltration of the stomach wall, with involvement of at least ... The CA 19-9 laboratory marker is associated with linitis plastica. A study found that a cutoff CA 19-9 level of 50 U/mL is ... Linitis plastica usually presents at an advanced stage with peritoneal involvement, which could appear as ascites or trabeculae ...
Primary gastric amyloidosis associated with linitis plastica and delayed progression to systemic amyloidosis and multiple ...
Malignant C9159 Gastric Diffuse Adenocarcinoma Adenocarcinoma of Linitis Plastica Type ,, Adenocarcinoma of the Linitis ... Plastica Type ,, Diffuse Adenocarcinoma of Stomach ,, Diffuse Adenocarcinoma of the Stomach ,, Diffuse Stomach Adenocarcinoma ...
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica. Gastric cancer : official ...
Linitis Plastica Preferred Term Term UI T023961. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Linitis Plastica Preferred Concept UI. M0012529. Scope Note. A condition where the stomach wall becomes thickened, rubbery and ... Linitis Plastica. Tree Number(s). C04.557.470.200.025.095.410. Unique ID. D008039. RDF Unique Identifier. http://id.nlm.nih.gov ...
Linitis plastica: The tumor infiltrates the stomach wall with an associated fibrous reaction that causes a rigid "leather ... may occur if the cancer obstructs the pyloric region or if the stomach becomes nondistensible secondary to linitis plastica. ...
Linitis plastica of stomach (disorder). Code System Preferred Concept Name. Linitis plastica of stomach (disorder). ...
... linitis plastica) without forming a distinct mass. Diffuse gastric cancer is also referred to as signet ring carcinoma or ... A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination. Eur J ... linitis plastica) without forming a distinct mass. Diffuse gastric cancer is also referred to as signet ring carcinoma or ... a phenomenon known as linitis plastica [McColl 2006]. No tumor mass is formed, unlike that of the intestinal type. The ...
Twelve patients (4.6%) demonstrated metastases to the stomach, eleven of whom presented with a linitis plastica pattern. ... Twelve patients (4.6%) demonstrated metastases to the stomach, eleven of whom presented with a linitis plastica pattern. ... Twelve patients (4.6%) demonstrated metastases to the stomach, eleven of whom presented with a linitis plastica pattern. ... Twelve patients (4.6%) demonstrated metastases to the stomach, eleven of whom presented with a linitis plastica pattern. ...
Diffuse; widespread: 3/4s or more; linitis plastica:. -Stomach and Esophagus GE Junction (C16.0-C16.6, C16.8, C16.9). Diffuse, ...
tract: Linitis plastica. *Familial adenomatous polyposis. *pancreas *Insulinoma. *Glucagonoma. *Gastrinoma. *VIPoma. * ...
Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A ...
A clinical lecture on linitis plastica, or leather bottle stomach.. Subject(s):. Stomach (Inflammation of, Hypertrophic) [ ... A case of linitis plastica.. Subject(s):. Stomach (Inflammation of, Hypertrophic) [ Linitis plastica ]. ...
... known as linitis plastica. Helicobacter pylori infection is associated with risk for both the intestinal and diffuse varieties ...
Colonoscopy revealed linitis plastica-like colon stenosis; however, biopsy pathology did not reveal any findings indicating ...
... such as linitis plastica, which have poor prognosis, especially in young patients [7, 8]. Genomic DNA modifications leading to ...
Diagnosis: Linitis plastica or diffuse carcinoma of the stomach; confirmed by non-distensibility on OGD and biopsies taken from ...
l(ft..RSTENS, H. C. and-----. Carcinoma of the colon simulating linitis plastica: Report of 2 cases. Proc. Staff Meet., Mayo ...
Linitis Plastica. Lipoma. Liposarcoma. Lymphangioma. Lymphocyte-Depleted Classical Hodgkin Lymphoma. Lymphocytic Leukemia. ...
  • Linitis plastica is a widely used term for Brinton's disease (also known as leather bottle stomach), a morphological variant of diffuse (or infiltrating) stomach cancer. (wikipedia.org)
  • Causes of cancerous linitis plastica are commonly primary gastric cancer, but in rarer cases could be metastatic infiltration of the stomach, particularly breast and lung carcinoma. (wikipedia.org)
  • My mother-in-law was diagnosed about a month ago with this rare linitis plastica stomach cancer. (cancer.org)
  • 4. [Linitis plastica of the stomach. (nih.gov)
  • 9. Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica. (nih.gov)
  • 16. Linitis plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass: a case report. (nih.gov)
  • A clinical lecture on linitis plastica, or leather bottle stomach. (nih.gov)
  • Linitis plastica is a malignant tumor that causes local gastric infiltration of the stomach wall, with involvement of at least one third of the total thickness. (medscape.com)
  • Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma that infiltrates into the stomach wall causing thickening of the wall ( linitis plastica ) without forming a distinct mass. (nih.gov)
  • Twelve patients (4.6%) demonstrated metastases to the stomach, eleven of whom presented with a linitis plastica pattern. (johnshopkins.edu)
  • 7. Gastric linitis plastica due to signet-ring cell carcinoma with Krukenberg tumors diagnosed by endoscopic ultrasound-guided fine-needle aspiration. (nih.gov)
  • Other historical synonymous names for linitis plastica include signet-ring cell carcinoma, Borrmann type 4 gastric carcinoma, and Lauren diffuse carcinoma. (medscape.com)
  • 12. Corrosive gastritis mimicking linitis plastica carcinoma. (nih.gov)
  • 17. The evolution of Linitis plastica as a consequence of advanced gastric carcinoma in pregnancy. (nih.gov)
  • 10. Endoscopic ultrasound-guided fine-needle aspiration used in diagnosing gastric linitis plastica: Metastatic lymph nodes can be valuable targets. (nih.gov)
  • 15. Gastric Linitis Plastica and role of endoscopic ultrasound: An under-recognised diagnostic modality. (nih.gov)
  • 19. [Intestinal linitis plastica: late metastasis from gastric signet ring cell adenocarcinoma]. (nih.gov)
  • The diffuse type pathology is characterized by poorly cohesive clusters of cells which infiltrate the gastric wall, leading to its widespread thickening and rigidity of the gastric wall, known as linitis plastica. (nih.gov)
  • 14. Gastric Linitis Plastica: Clinical Characteristics and Outcomes from the National Cancer Database. (nih.gov)
  • In a large linitis plastica cohort study in the National Cancer Database, 51.9% of cases occurred in females and 48.1% occurred in males. (medscape.com)
  • Extensive gastric involvement may resemble linitis plastica. (medscape.com)
  • Linitis plastica usually presents at an advanced stage with peritoneal involvement, which could appear as ascites or trabeculae, as in the patient in this case. (medscape.com)
  • Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. (journal-jmsr.net)
  • Linitis plastica is a type of adenocarcinoma and accounts for 3-19% of gastric adenocarcinomas. (wikipedia.org)
  • 6. Linitis Plastica: a Distinct Type of Gastric Cancer. (nih.gov)
  • A case of linitis plastica. (nih.gov)
  • 20. Linitis plastica: current prognostic implication of a classic concept. (nih.gov)
  • [ 7 ] Other markers associated with linitis plastica include CEA and cancer antigen 72-4. (medscape.com)
  • The genetic risk factor for linitis plastica is a mutation in the CDH1 gene called the E-cadherin mutation, especially in patients who have a family history. (medscape.com)
  • Linitis plastica is common in women and in poorly differentiated and signet ring cell histologies: an analysis of 217 patients (abstract). (medscape.com)