Marburg virus disease. Medical search. Definitions

An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.

A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.

A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.

A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.

A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.

Infections with viruses of the family FILOVIRIDAE. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.

A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.

A general term for diseases produced by viruses.

A species of ALPHAVIRUS associated with epidemic EXANTHEMA and polyarthritis in Australia.

A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.

Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. (1/99)

Since the Marburg (MBG) and Ebola (EBO) viruses have sequence homology and cause similar diseases, we hypothesized that they associate with target cells by similar mechanisms. Pseudotype viruses prepared with a luciferase-containing human immunodeficiency virus type 1 backbone and packaged by the MBG virus or the Zaire subtype EBO virus glycoproteins (GP) mediated infection of a comparable wide range of mammalian cell types, and both were inhibited by ammonium chloride. In contrast, they exhibited differential sensitivities to treatment of target cells with tunicamycin, endoglycosidase H, or protease (pronase). Therefore, while they exhibit certain functional similarities, the MBG and EBO virus GP interact with target cells by distinct processes. (+info)

Viewpoint: filovirus haemorrhagic fever outbreaks: much ado about nothing? (2/99)

The recent outbreak of Marburg haemorrhagic fever in the Democratic Republic of Congo has put the filovirus threat back on the international health agenda. This paper gives an overview of Marburg and Ebola outbreaks so far observed and puts them in a public health perspective. Damage on the local level has been devastating at times, but was marginal on the international level despite the considerable media attention these outbreaks received. The potential hazard of outbreaks, however, after export of filovirus from its natural environment into metropolitan areas, is argued to be considerable. Some avenues for future research and intervention are explored. Beyond the obvious need to find the reservoir and study the natural history, public health strategies for a more timely and efficient response are urgently needed. (+info)

Enzyme-linked immunosorbent assays for detection of antibodies to Ebola and Marburg viruses using recombinant nucleoproteins. (3/99)

The full-length nucleoprotein (NP) of Ebola virus (EBO) was expressed as a His-tagged recombinant protein (His-EBO-NP) by a baculovirus system. Carboxy-terminal halves of NPs of EBO and Marburg virus (MBG) were expressed as glutathione S-transferase-tagged recombinant proteins in an Escherichia coli system. The antigenic regions on the NPs of EBO and MBG were determined by both Western blotting and enzyme-linked immunosorbent assay (ELISA) to be located on the C-terminal halves. The C-terminal 110 and 102 amino acids of the NPs of EBO and MBG, respectively, possess strong antigenicity. The full-length NP of EBO was strongly expressed in insect cells upon infection with the recombinant baculovirus, while expression of the full-length NP of MBG was weak. We developed an immunoglobulin G (IgG) ELISA using His-EBO-NP and the C-terminal halves of the NPs of EBO and MBG as antigens. We evaluated the IgG ELISA for the ability to detect IgG antibodies to EBO and MBG, using human sera collected from EBO and MBG patients. The IgG ELISA with the recombinant NPs showed high sensitivity and specificity in detecting EBO and MBG antibodies. The results indicate that ELISA systems prepared with the recombinant NPs of EBO and MBG are valuable tools for the diagnosis of EBO and MBG infections and for seroepidemiological field studies. (+info)

VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment. (4/99)

Localization of VP40 in Marburg virus (MBGV)-infected cells was studied by using immunofluorescence and immunoelectron microscopic analysis. VP40 was detected in association with nucleocapsid structures, present in viral inclusions and at sites of virus budding. Additionally, VP40 was identified in the foci of virus-induced membrane proliferation and in intracellular membrane clusters which had the appearance of multivesicular bodies (MVBs). VP40-containing MVBs were free of nucleocapsids. When analyzed by immunogold labeling, the concentration of VP40 in MVBs was six times higher than in nucleocapsid structures. Biochemical studies showed that recombinant VP40 represented a peripheral membrane protein that was stably associated with membranes by hydrophobic interaction. Recombinant VP40 was also found in association with membranes of MVBs and in filopodia- or lamellipodia-like protrusions at the cell surface. Antibodies against marker proteins of various cellular compartments showed that VP40-positive membranes contained Lamp-1 and the transferrin receptor, confirming that they belong to the late endosomal compartment. VP40-positive membranes were also associated with actin. Western blot analysis of purified MBGV structural proteins demonstrated trace amounts of actin, Lamp-1, and Rab11 (markers of recycling endosomes), while markers for other cellular compartments were absent. Our data indicate that MBGV VP40 was able to interact with membranes of late endosomes in the course of viral infection. This capability was independent of other MBGV proteins. (+info)

Immunoglobulin M and G responses measured by immunofluorescence in patients with Lassa or Marburg virus infections. (5/99)

Immunoglobulin M antibodies can be measured by indirect immunofluorescence in sera of patients suffering from Lassa fever or Marburg virus disease 4-7 days after onset of illness. Titres reach a peak 1-2 weeks later. These antibodies disappear, or titres decrease considerably, 1-2 months after onset of illness. Antiviral IgG antibodies can be detected at the same time as, or a little later than, IgM antibodies, but they persist much longer. None of the three patients discussed in this paper who died of Lassa fever developed IgG antibodies and only one developed IgM antibodies. (+info)

Short communication: a cluster of Marburg virus disease involving an infant. (6/99)

A noteworthy cluster of six cases of Marburg haemorrhagic fever (MHF) was identified in the Democratic Republic of Congo. One of the cases is the first infant Marburg fever patient ever documented. Three of six cases presented surprisingly mild symptoms. The results of epidemiological and virological investigations are compatible with person-to-person transmission through body fluids and with mother-to-child transmission while nurturing. The findings show that mild cases of MHF have to be expected during an outbreak and point out the difficulty to base patient management decisions on clinical case definitions alone. (+info)

Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes. (7/99)

Monoclonal antibodies (MAbs) reactive with Marburg virus (strain Musoke) were evaluated for both biological activity and specificity. Several of the Marburg virus- (MBGV) specific MAbs reduced the size and/or number of MBGV plaques in vitro. The ability of the MAbs to affect plaque formation in vitro was demonstrated to be specific for the glycoprotein (GP) of the strain of MBGV used for vaccination. Using deletion analysis and peptide mapping, the binding epitopes of several of these neutralizing MAbs were identified. Not unexpectedly, the epitopes were shown to lie in the most hypervariable and highly glycosylated region of MBGV GP. An analysis of the in vivo activity of several MAbs revealed that some antibodies provided substantial but incomplete protection of naive guinea pigs by passive transfer. These data suggest that neutralizing epitopes exist within MBGV GP but that induction of antibodies to these neutralizing epitopes may not be sufficient for protection from lethal infection. (+info)

Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. (8/99)

We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo. Questionnaires were administered and serum samples tested for Marburg-specific antibodies by enzyme-linked immunosorbent assay. Fifteen (2%) of 912 participants in a general village cross-sectional antibody survey were positive for Marburg immunoglobulin G antibody. Thirteen (87%) of these 15 were men who worked in the local gold mines. Working as a miner (odds ratio [OR] 13.9, 95% confidence interval [CI] 3.1 to 62.1) and receiving injections (OR 7.4, 95% CI 1.6 to 33.2) were associated with a positive antibody result. All 103 participants in a targeted antibody survey of healthcare workers were antibody negative. Primary transmission of Marburg virus to humans likely occurred via exposure to a still unidentified reservoir in the local mines. Secondary transmission appears to be less common with Marburg virus than with Ebola virus, the other known filovirus. (+info)

Marburg Virus Disease (MVD) is an acute and often fatal viral hemorrhagic fever illness caused by the Marburg virus, a member of the filovirus family. It's a highly infectious disease that can be transmitted from human to human through direct contact with infected bodily fluids, tissues, or indirectly through contaminated surfaces and materials.

The incubation period for MVD ranges from 2 to 21 days, after which symptoms such as fever, chills, headache, muscle aches, severe malaise, and progressive weakness appear. Around the fifth day of illness, a maculopapular rash may occur, followed by diarrhea, nausea, vomiting, abdominal pain, and non-bloody stools. In some cases, patients may develop severe bleeding disorders, shock, liver failure, and multi-organ dysfunction, which can lead to death in 24-48 hours.

Currently, there are no approved vaccines or antiviral treatments for MVD, but supportive care is crucial for managing the symptoms of the disease. Preventive measures such as avoiding contact with infected individuals and their bodily fluids, wearing protective clothing, and practicing good hygiene can help prevent the spread of the virus.

According to the World Health Organization (WHO), Marburgviruses are toxiviral hemorrhagic fever-causing agents that belong to the Filoviridae family, which also includes Ebolaviruses. These enveloped, non-segmented, negative-stranded RNA viruses cause a severe and often fatal illness in humans and non-human primates. The Marburg virus was initially discovered in 1967, after simultaneous outbreaks occurred in laboratories in Marburg and Frankfurt, Germany, and in Belgrade, Yugoslavia (now Serbia).

The virions of Marburgviruses are typically filamentous or U-shaped and measure approximately 80 nm in diameter. The genome consists of a single non-segmented, negative-sense RNA molecule that encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor protein (VP35), matrix protein (VP40), glycoprotein (GP), transcription activator protein (VP30), RNA-dependent RNA polymerase (L), and a small hydrophobic protein (sVP24 or VP80).

Marburgviruses are primarily transmitted to humans through contact with the bodily fluids of infected animals, such as bats and non-human primates. Human-to-human transmission can occur via direct contact with infected individuals' blood, secretions, organs, or other bodily fluids, as well as through contaminated surfaces and materials.

The incubation period for Marburg virus disease (MVD) typically ranges from 2 to 21 days. Initial symptoms include fever, chills, headache, muscle aches, and general malaise. As the disease progresses, patients may develop severe watery diarrhea, abdominal pain, nausea, vomiting, and unexplained bleeding or bruising. In fatal cases, MVD can cause multi-organ failure, shock, and death, often within 7 to 14 days after symptom onset.

Currently, there are no approved vaccines or antiviral treatments specifically for Marburg virus infections. However, supportive care, such as fluid replacement, electrolyte management, and treatment of secondary infections, can help improve outcomes for MVD patients. Preventive measures, including the use of personal protective equipment (PPE) and proper infection control practices, are crucial to reducing the risk of transmission during outbreaks.

Filoviridae is a family of negative-sense, single-stranded RNA viruses that includes three genera: Ebolavirus, Marburgvirus, and Cuevavirus. These viruses are known to cause severe hemorrhagic fever in humans and nonhuman primates, with high fatality rates. The most well-known members of this family are Ebola virus and Marburg virus.

The virions of Filoviridae are filamentous, often having a "U," "6," or "hook" shape, and can be up to 14,000 nanometers in length. The genome of these viruses is non-segmented and contains seven genes that encode for structural proteins and enzymes necessary for replication.

Transmission of Filoviridae occurs through direct contact with infected bodily fluids or contaminated surfaces, and infection can result in a range of symptoms including fever, severe headache, muscle pain, weakness, fatigue, and hemorrhage. There are currently no approved vaccines or antiviral treatments for Filoviridae infections, although several are in development.

Ebolavirus is a genus of viruses in the family Filoviridae, order Mononegavirales. It is named after the Ebola River in the Democratic Republic of Congo (formerly Zaire), where the virus was first identified in 1976. There are six species of Ebolavirus, four of which are known to cause disease in humans: Zaire ebolavirus, Sudan ebolavirus, Bundibugyo ebolavirus, and Tai Forest ebolavirus (formerly Cote d'Ivoire ebolavirus). The fifth species, Reston ebolavirus, is known to cause disease in non-human primates and pigs, but not in humans. The sixth and most recently identified species, Bombali ebolavirus, has not been associated with any human or animal diseases.

Ebolaviruses are enveloped, negative-sense, single-stranded RNA viruses that cause a severe and often fatal hemorrhagic fever in humans and non-human primates. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats of the Pteropodidae family are considered to be the natural host of Ebolavirus.

The symptoms of Ebolavirus disease (EVD) typically include fever, severe headache, muscle pain, weakness, fatigue, and sore throat, followed by vomiting, diarrhea, rash, impaired kidney and liver function, and in some cases, both internal and external bleeding. The case fatality rate of EVD is variable but has been historically high, ranging from 25% to 90% in past outbreaks depending on the species and the quality of medical care. There are no licensed specific treatments or vaccines available for EVD, although several promising candidates are currently under development.

**Hemorrhagic fevers, viral** are a group of severe, potentially fatal illnesses caused by viruses that affect the body's ability to regulate its blood vessels and clotting abilities. These viruses belong to several different families including *Filoviridae* (e.g., Ebola, Marburg), *Arenaviridae* (e.g., Lassa, Machupo), *Bunyaviridae* (e.g., Hantavirus, Crimean-Congo hemorrhagic fever virus) and *Flaviviridae* (e.g., Dengue, Yellow Fever).

The initial symptoms are non-specific and include sudden onset of fever, fatigue, muscle aches, joint pains, headache, and vomiting. As the disease progresses, it may lead to capillary leakage, internal and external bleeding, and multi-organ failure resulting in shock and death in severe cases.

The transmission of these viruses can occur through various means depending on the specific virus. For example, some are transmitted via contact with infected animals or their urine/feces (e.g., Hantavirus), others through insect vectors like ticks (Crimean-Congo hemorrhagic fever) or mosquitoes (Dengue, Yellow Fever), and yet others through direct contact with infected body fluids (Ebola, Marburg).

There are no specific treatments for most viral hemorrhagic fevers. However, some experimental antiviral drugs have shown promise in treating certain types of the disease. Supportive care, such as maintaining blood pressure, replacing lost fluids and electrolytes, and managing pain, is critical to improving outcomes. Prevention measures include avoiding areas where the viruses are common, using personal protective equipment when caring for infected individuals or handling potentially contaminated materials, and controlling insect vectors.

Sources: Centers for Disease Control and Prevention (CDC), World Health Organization (WHO).

Filoviridae infections refer to diseases caused by viruses belonging to the Filoviridae family, which includes Ebola virus and Marburg virus. These viruses are characterized by filamentous or threadlike shapes and can cause severe hemorrhagic fever in humans and primates. The infections are associated with high mortality rates, ranging from 25% to 90%, depending on the specific virus and strain.

Transmission of Filoviridae viruses occurs through direct contact with infected bodily fluids or contaminated surfaces. The initial symptoms of infection include fever, muscle pain, headache, and sore throat, followed by vomiting, diarrhea, rash, and impaired organ function. In severe cases, the disease can progress to hemorrhagic fever, characterized by internal and external bleeding, shock, and multi-organ failure.

Currently, there are no approved vaccines or antiviral treatments for Filoviridae infections, although several experimental therapies and vaccines are under development. Prevention measures include avoiding contact with infected individuals, practicing good hygiene, and using personal protective equipment when caring for sick patients.

Ebola Hemorrhagic Fever (EHF) is a severe, often fatal illness in humans. It is one of the five identified subtypes of the Ebolavirus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission.

The early symptoms include sudden onset of fever, fatigue, muscle pain, headache and sore throat. This is followed by vomiting, diarrhea, rash, symptoms of impaired kidney and liver function, and in some cases, both internal and external bleeding.

Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes.

The virus is introduced into the human population through close contact with the blood, secretions, organs or other bodily fluids of infected animals such as fruit bats, porcupines and non-human primates. Then it spreads in communities through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials contaminated with these fluids.

Healthcare workers have frequently been infected while treating patients with suspected or confirmed EVD due to a lack of adequate infection prevention and control measures.

There are currently no approved specific antiviral drugs or vaccines for Ebola. Several promising treatments and vaccine candidates are being evaluated.

Viral diseases are illnesses caused by the infection and replication of viruses in host organisms. These infectious agents are obligate parasites, meaning they rely on the cells of other living organisms to survive and reproduce. Viruses can infect various types of hosts, including animals, plants, and microorganisms, causing a wide range of diseases with varying symptoms and severity.

Once a virus enters a host cell, it takes over the cell's machinery to produce new viral particles, often leading to cell damage or death. The immune system recognizes the viral components as foreign and mounts an immune response to eliminate the infection. This response can result in inflammation, fever, and other symptoms associated with viral diseases.

Examples of well-known viral diseases include:

1. Influenza (flu) - caused by influenza A, B, or C viruses
2. Common cold - usually caused by rhinoviruses or coronaviruses
3. HIV/AIDS - caused by human immunodeficiency virus (HIV)
4. Measles - caused by measles morbillivirus
5. Hepatitis B and C - caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), respectively
6. Herpes simplex - caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2)
7. Chickenpox and shingles - both caused by varicella-zoster virus (VZV)
8. Rabies - caused by rabies lyssavirus
9. Ebola - caused by ebolaviruses
10. COVID-19 - caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Prevention and treatment strategies for viral diseases may include vaccination, antiviral medications, and supportive care to manage symptoms while the immune system fights off the infection.

Ross River virus (RRV) is an infectious disease caused by the Ross River virus, which is a type of alphavirus. It is transmitted to humans through the bite of infected mosquitoes, primarily Aedes vigilax, Culex annulirostris, and Culex australicus in Australia.

RRV is endemic to Australia, Papua New Guinea, and some islands in the Pacific Ocean. The symptoms of RRV include fever, rash, joint pain and swelling, muscle aches, fatigue, and headache, which can last for several weeks to months. In severe cases, it can lead to chronic arthritis and other long-term complications.

There is no specific treatment for RRV, and management typically involves relieving symptoms with rest, fluids, and pain relief medications. Preventive measures include avoiding mosquito bites by using insect repellent, wearing protective clothing, and staying indoors during peak mosquito activity hours.

The Democratic Republic of the Congo (DRC) is a country located in Central Africa. It is named after the Congo River, which flows through the country. The DRC is the second-largest country in Africa by area and the eleventh-largest in the world. It is home to a diverse population of more than 80 million people, making it one of the most populous countries on the continent.

The DRC is a democratic republic, which means that it is a form of government in which the people have the power to choose their leaders through free and fair elections. The country has a presidential system of government, in which the president serves as both the head of state and the head of government. The current president of the DRC is Félix Tshisekedi, who took office in January 2019.

The DRC is a federal republic, meaning that it is divided into several provinces, each with its own elected government. The country has a total of 26 provinces, which are further divided into districts and sectors.

The DRC is a member of various international organizations, including the United Nations, the African Union, and the Southern African Development Community. It is also a party to several international treaties and agreements, such as the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) and the Paris Agreement on climate change.

The DRC has a mixed economy, with both private and public sectors playing important roles. The country is rich in natural resources, including minerals such as copper, diamonds, gold, and tin. It also has large areas of fertile land that are suitable for agriculture. However, the DRC faces significant challenges, including poverty, corruption, and conflict. Despite these challenges, the country has made progress in recent years in terms of economic growth and development.

Martini, G. A. (1971). "Marburg Virus Disease. Clinical Syndrome". In Martini, G. A.; Siegert, R. (eds.). Marburg Virus Disease ... Scholia has a topic profile for Marburg virus disease. ViralZone: Marburg virus Centers for Disease Control, Infection Control ... List of other Filoviridae outbreaks "Ebola Virus Disease & Marburg Virus Disease - Chapter 3 - 2018 Yellow Book , Travelers' ... Marburg virus (MARV) and Ravn virus (RAVV). Its clinical symptoms are very similar to those of Ebola virus disease (EVD). ...

https://en.wikipedia.org/wiki/Marburg_virus_disease

"Marburg (Marburg Virus Disease) , Marburg (Marburg Virus Disease) , CDC". www.cdc.gov. 19 April 2023. Retrieved 19 April 2023 ... Marburg virus disease is a viral hemorrhagic fever caused by the Marburg virus, with a case fatality ratio of up to 88 percent ... Symptoms are similar to Ebola virus disease and like Ebola, Marburg virus spreads through contact with body fluids of infected ... 2023 disease outbreaks, Marburg virus outbreaks, Disease outbreaks in Tanzania, 2023 disasters in Africa, April 2023 events in ...

https://en.wikipedia.org/wiki/2023_Marburg_virus_disease_outbreak_in_Tanzania

"Update on Marburg Virus Disease Outbreak in Ghana" (Tweet) - via Twitter. {{cite web}}: Check ,url= value (help) "Marburg virus ... Marburg virus disease (MVD) is a highly virulent, epidemic-prone disease, associated with a high case-fatality ratio of 24-90 ... 2022 disease outbreaks, July 2022 events in Africa, Marburg virus outbreaks, Disease outbreaks in Ghana, 2022 disasters in ... In July 2022, an outbreak of Marburg virus disease occurred in Ghana. Two positive cases were reported by Ghana on 8 July. ...

https://en.wikipedia.org/wiki/2022_Marburg_virus_disease_outbreak_in_Ghana

"Marburg virus: Man who died in Guinea found to have disease". BBC News. Retrieved 3 December 2021. "Marburg virus disease - ... Marburg virus disease is a highly virulent, epidemic-prone disease, associated with a high case-fatality ratio of 24-90%. In ... "Guinea declares end of Marburg virus outbreak". CNN. CNN. Retrieved 18 September 2021. "Malburg virus disease - Guinea". World ... Angola-like Marburg virus and Marburg virus, which are genetically similar to variants from Uganda, Gabon, and the Democratic ...

https://en.wikipedia.org/wiki/2021_Marburg_virus_disease_outbreak_in_Guinea

"Marburg (Marburg Virus Disease) , Marburg (Marburg Virus Disease) , CDC". www.cdc.gov. 8 August 2022. Archived from the ... Marburg virus disease is a viral hemorrhagic fever caused by the Marburg virus, with a case fatality ratio of up to 88 percent ... "WHO declares end to Marburg virus outbreak in Equatorial Guinea". France 24. Retrieved 19 June 2023. "Marburg Virus Disease ... it was identified as being Marburg virus disease. It was the first time the disease was detected in the country. As of 4 April ...

https://en.wikipedia.org/wiki/2023_Marburg_virus_disease_outbreak_in_Equatorial_Guinea

... was first described in 1967. It was discovered that year during a set of outbreaks of Marburg virus disease in ... Marburg virus (MARV) is a hemorrhagic fever virus of the Filoviridae family of viruses and a member of the species Marburg ... marburgvirus, genus Marburgvirus. It causes Marburg virus disease in primates, a form of viral hemorrhagic fever. The virus is ... of the species Marburg marburgvirus because their genomes diverge from the prototype Marburg marburgvirus or the Marburg virus ...

https://en.wikipedia.org/wiki/Marburg_virus

The 1967 Marburg virus outbreak was the first recorded outbreak of Marburg virus disease. It started in early August 1967 when ... "Ebola Virus Disease & Marburg Virus Disease - Chapter 3 - 2018 Yellow Book , Travelers' Health , CDC". wwwnc.cdc.gov. Centers ... Disease outbreaks in Germany, 1967 disease outbreaks, Hemorrhagic fevers outbreaks, Tropical diseases, Marburg virus outbreaks ... Bebell, Lisa M.; Riley, Laura E. (June 2015). "Ebola Virus Disease and Marburg Disease in Pregnancy". Obstetrics & Gynecology. ...

https://en.wikipedia.org/wiki/1967_Marburg_virus_outbreak

Marburg virus disease Marburg virus Filoviridae Athumani, Halima. "Uganda Confirms 1 Death From Ebola-like Marburg Virus". VOA ... "Ebola-like Marburg virus kills two in Uganda". Daily Nation. Retrieved 21 October 2017. "Marburg virus disease - Uganda and ... "Ebola Virus Disease & Marburg Virus Disease - Chapter 3 - 2018 Yellow Book , Travelers' Health , CDC". wwwnc.cdc.gov. Centers ... "Uganda ends Marburg virus disease outbreak". ReliefWeb. Retrieved 8 December 2017. "WHO , Marburg haemorrhagic fever in Uganda ...

https://en.wikipedia.org/wiki/2017_Uganda_Marburg_virus_outbreak

Marburg virus (MARV) and Ravn virus (RAVV). Both viruses cause Marburg virus disease in humans and nonhuman primates, a form of ... where Marburg virus was first discovered), and the taxonomic suffix -virus (which denotes a virus genus). Even though the virus ... The genus currently includes a single virus species, Marburg marburgvirus. The members of the genus (i.e. the actual physical ... The genus Marburgvirus is the taxonomic home of Marburg marburgvirus, whose members are the two known marburgviruses, ...

https://en.wikipedia.org/wiki/Marburgvirus

"Outbreake of Marburg virus disease in Johannesburg". British Medical Journal. 4 (5995): 489-93. doi:10.1136/bmj.4.5995.489. PMC ... In patients with these conditions, the pseudo-Pelger-Huët cells tend to appear late in the disease and often appear after ... "Pelger-Huet anomaly". Disease Infosearch. Retrieved 2020-04-27. Creative Commons Attribution 3.0 License Cunningham, John M.; ... It has also been described in Filovirus disease. ...

https://en.wikipedia.org/wiki/Pelger–Huët_anomaly

"Multidistrict outbreak of Marburg virus disease-Uganda, 2012". The Journal of Infectious Diseases. 212 Suppl 2 (Suppl 2): S119- ... Multidistrict outbreak of Marburg virus disease-Uganda, 2012. 2015: Is the glass half full or half empty? A qualitative ... Aceng, Jane Ruth; Ario, Alex R.; Muruta, Allan N.; Makumbi, Issa (19 March 2020). "Uganda's experience in Ebola virus disease ... Infectious Diseases Institute (16 July 2016). "Infectious Diseases Institute: Board Members: Dr Jane Ruth Aceng". Kampala: ...

https://en.wikipedia.org/wiki/Jane_Aceng

MHF is Marburg hemorrhagic fever, renamed Marburg virus disease. MHF may also refer to: Mamaa language (by ISO 639 code) ...

https://en.wikipedia.org/wiki/MHF_(disambiguation)

"Africa braces against Marburg virus after Ghana cases". medicalxpress.com. Retrieved 31 August 2022. "Marburg virus disease - ... Ebola virus (EBOV), Sudan virus (SUDV), Reston virus (RESTV), Taï Forest virus (TAFV), and Bundibugyo virus (BDBV). Four of the ... "Marburg Virus Disease outbreak in Tanzania declared over". World Health Organization. 2 June 2023. Retrieved 3 June 2023. de ... "Marburg virus disease - Uganda". World Health Organization. Archived from the original on 26 October 2017. Retrieved 29 August ...

https://en.wikipedia.org/wiki/List_of_Ebola_outbreaks

Ebola virus disease or Marburg virus) than typhus or typhoid. Unusual in the history of plagues during military operations, ... the type of primates responsible for transmitting Marburg virus into Germany and Yugoslavia when that disease was first ... Given the possibility that profiles of a known disease may have changed over time, or that the plague was caused by a disease ... The lack of a durable signature by RNA viruses means some etiologies, notably the hemorrhagic fever viruses, are not testable ...

https://en.wikipedia.org/wiki/Plague_of_Athens

This was later determined to be Marburg virus. See main article at 2023 Marburg virus disease outbreak in Equatorial Guinea. 13 ... "Equatorial Guinea confirms country's first Marburg virus disease outbreak -WHO". Reuters. 14 February 2023. "ABS-CBN". February ... 23 March - Equatorial Guinea confirms eight new cases of the Marburg virus, bringing the total cases to nine in the country. " ... "Equatorial Guinea confirms 8 new cases of Marburg virus". AP NEWS. 2023-03-23. Retrieved 2023-04-05. (Articles with short ...

https://en.wikipedia.org/wiki/2023_in_Equatorial_Guinea

In the 1980s, two visitors to the cave contracted Marburg virus disease. In 1980, a French man died from the disease after ... "Marburg Virus in Fruit Bat, Kenya". Emerging Infectious Diseases. Centers for Disease Control and Prevention (CDC). 16 (2): 352 ... In the 1980s, two European visitors contracted Marburg virus disease there. It is one of five named "elephant caves" of Mount ... Despite sampling a wide variety of species (including fruit bats), no Marburg disease-causing viruses were found and the animal ...

https://en.wikipedia.org/wiki/Kitum_Cave

Lowland grazing and Marburg virus disease (MVD) outbreak in Kween district, Eastern Uganda. The study concluded that there is ... "Lowland grazing and Marburg virus disease (MVD) outbreak in Kween district, Eastern Uganda". BMC Public Health. 19 (1): 136. ... This article discovered that most of the patients with COVID-19 presented with mild disease and exhibited a clinical trajectory ... concepts within agricultural extension service provision in Uganda so as to enhance the management of such infectious diseases ...

https://en.wikipedia.org/wiki/William_Bazeyo

Infectious diseases such as Ebola, Marburg virus disease and yellow fever can cause bleeding.[citation needed] Dioxaborolane ... This is a rare condition that is most likely to occur in older patients and in those with autoimmune diseases. Another common ... For instance, deficiency of Factor VIII causes classic hemophilia A while deficiencies of Factor IX cause "Christmas disease"( ... bleeding disorder is Von Willebrand disease. It is caused by a deficiency or abnormal function of the "Von Willebrand" factor, ...

https://en.wikipedia.org/wiki/Bleeding

... (/ˈrævən/; RAVV) is a close relative of Marburg virus (MARV). RAVV causes Marburg virus disease in humans and ... Marburg virus (MARV). A virus that fulfills the criteria for being a member of the species Marburg marburgvirus is a Ravn virus ... and the taxonomic suffix virus. Ravn virus was first introduced as a new subtype of Marburg virus in 1996. In 2006, a whole- ... Today, the virus is classified as one of two members of the species Marburg marburgvirus, which is included into the genus ...

https://en.wikipedia.org/wiki/Ravn_virus

An outbreak of Marburg virus disease began in Nsok-Nsomo in February 2023, promoting a local lockdown. Subdivisions of ... "Equatorial Guinea declares outbreak of Ebola-like Marburg virus". BNO News. Retrieved 13 February 2023. v t e ) (Articles with ...

https://en.wikipedia.org/wiki/Nsok-Nsomo

It was caused by Marburg virus which is an African RNA virus that causes green monkey disease. Now thought to be under control ... Beginning in October 2004 and continuing into 2005, Uíge Province was the centre of an outbreak of Marburg hemorrhagic fever, a ...

https://en.wikipedia.org/wiki/Uíge_Province

... and Marburgvirus. The presence of Marburgvirus, which causes Marburg virus disease, has been confirmed in one species, the ... The United States Centers for Disease Control and Prevention lists a total of 601 confirmed cases of Marburg virus disease from ... Flying foxes can transmit several non-lethal diseases as well, such as Menangle virus and Nelson Bay virus. These viruses ... "Ebola (Ebola Virus Disease): Transmission". Centers for Disease Control and Prevention. 17 May 2019. Retrieved 30 May 2019. " ...

https://en.wikipedia.org/wiki/Megabat

In 1998 the Orientale villages of Durba and Watsa were the center of an outbreak of Marburg virus disease among gold mine ... the epicenter of the 1998 outbreak of Marburg hemorrhagic fever." "Liste des gouverneurs de la Province Orientale". ...

https://en.wikipedia.org/wiki/Orientale_Province

Chikungunya virus, COVID-19, Crimean-Congo haemorrhagic fever, Dengue, Ebola virus disease, HIV, Malaria, Marburg virus disease ... Geisbert TW, Feldmann H (November 2011). "Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus ... Clinical studies have utilized such viruses on a range of diseases in model animals such as mice, chicken and primates. mRNA ... and Chikungunya virus. In March 2022 Moderna announced the development of mRNA vaccines for 15 diseases: ...

https://en.wikipedia.org/wiki/MRNA_vaccine

Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a ... Two members of the family that are commonly known are Ebola virus and Marburg virus. Both viruses, and some of their lesser ... Tai Forest virus, Sudan virus, and Reston virus) estimated at 1000-2100 years. The most recent common ancestor of the Marburg ... Primate diseases, Animal viral diseases, Biological weapons, Hemorrhagic fevers, Tropical diseases, Zoonoses, Virus families). ...

https://en.wikipedia.org/wiki/Filoviridae

In September 2013, NIAID contracted with BioCryst for the development of galidesivir as a treatment for Marburg virus disease ... Marburg, Yellow Fever and Zika viruses. BioCryst is developing galidesivir in collaboration with U.S. government agencies and ... The company is a late stage biotech company that focuses on oral drugs for rare and serious diseases. BioCryst's antiviral drug ... BCX9930, an oral Factor D inhibitor for the treatment of complement-mediated diseases. FDA has granted Fast Track designation ...

https://en.wikipedia.org/wiki/BioCryst_Pharmaceuticals

Kabila The villages of Durba and Watsa in Orientale Province are the center of an outbreak of Marburg virus disease among gold ...

https://en.wikipedia.org/wiki/1998_in_the_Democratic_Republic_of_the_Congo

... but was then repurposed and studied as a potential treatment for Ebola virus disease and Marburg virus infections. According to ... and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection ... In some viruses, such as the respiratory syncytial virus, it causes the RNA-dependent RNA polymerases to pause, but its ... for remdesivir for the treatment of Ebola virus disease. In April 2020, the European Medicines Agency (EMA) provided ...

https://en.wikipedia.org/wiki/Remdesivir

Marburg virus disease, Crimean-Congo haemorrhagic fever (CCHF) and yellow fever. Lassa, Ebola, Marburg and CCHF can be spread ... There are a number of different viral hemorrhagic fevers including Ebola virus disease, Lassa fever, Rift valley fever, ... This provides some protection against transmission of VHF and other diseases. This requires at least cake soap cut into small ... Wash hands with soap and clean water before leaving the changing room Disinfection kills almost all bacteria, fungi, viruses, ...

https://en.wikipedia.org/wiki/Prevention_of_viral_hemorrhagic_fever

Between 1998 and 2000, co-circulating Marburg virus and Ravn virus caused 154 cases of Marburg virus disease and 128 deaths ... 2006). "Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of Virus" (PDF). New England Journal of Medicine. ...

https://en.wikipedia.org/wiki/Haut-Uele_District

Recommendations for Marburg virus disease (MVD) infection prevention. ... Marburg virus disease (MVD) is caused by a group of viruses called marburgviruses and is a rare type of viral hemorrhagic fever ... Recommendations for Marburg virus disease (MVD) infection prevention and control precautions are the same as for Ebola Disease ... should monitor their health for 21 days and seek medical care immediately if they develop symptoms of Marburg virus disease. ...

https://www.cdc.gov/vhf/marburg/prevention/index.html

Marburg virus disease in Uganda - http://www.who.int/csr/don/25-october-2017-marburg-uganda/en/ ... Please note for your information that a Disease Outbreak News has been posted by WHO for the following public health event:. · ... Главная » Marburg virus disease in Uganda Marburg virus disease in Uganda Опубликовано ср, 10/25/2017 - 14:09 пользователем ...

https://extranet.who.int/pagnet/?q=ru/content/marburg-virus-disease-uganda

Provided by the Centers for Disease Control and Prevention (CDC). ... Marburg Virus Disease) , Marburg (Marburg Virus Disease) , CDC ... Marburg virus disease is a rare but highly fatal viral hemorrhagic fever caused by two zoonotic viruses, Marburg virus and Ravn ... and biosafety precautions that apply to Ebola Disease also apply to Marburg Virus Disease (MVD) in U.S. healthcare settings. ... MVD is a serious and often deadly disease. When living in or traveling to a region where Marburg virus is potentially present, ...

https://emergency.cdc.gov/han/2023/han00489.asp

Etymologia: Marburg Virus. Emerging Infectious Diseases. 2017;23(10):1689. doi:10.3201/eid2310.et2310.. ... A new virus, named Marburg virus, was isolated from patients and monkeys, and the high case-fatality ratio called for the best ... Marburg virus. Ann N Y Acad Sci. 1970;174(2 Unusual Isola):932-45. DOIPubMedGoogle Scholar ... Etymologia: Marburg Virus. Volume 23, Number 10-October 2017. Article Views: 459. Data is collected weekly and does not include ...

https://wwwnc.cdc.gov/eid/article/23/10/et-2310_article

Marburg virus disease is a highly virulent disease that causes haemorrhagic fever, with a fatality ratio of up to 88%. It is in ... It can be difficult to clinically distinguish Marburg virus disease from other infectious diseases such as malaria, typhoid ... Human infection with Marburg virus disease initially results from prolonged exposure to mines or caves inhabited by Rousettus ... Based on further analysis of ongoing research, WHO recommends that male survivors of Marburg virus disease practise safer sex ...

http://www.emro.who.int/fr/health-topics/marburg-virus-disease/index/Page-1.html

Martini, G. A. (1971). "Marburg Virus Disease. Clinical Syndrome". In Martini, G. A.; Siegert, R. (eds.). Marburg Virus Disease ... Scholia has a topic profile for Marburg virus disease. ViralZone: Marburg virus Centers for Disease Control, Infection Control ... List of other Filoviridae outbreaks "Ebola Virus Disease & Marburg Virus Disease - Chapter 3 - 2018 Yellow Book , Travelers ... Marburg virus (MARV) and Ravn virus (RAVV). Its clinical symptoms are very similar to those of Ebola virus disease (EVD). ...

https://en.wikipedia.org/wiki/Marburg_virus_disease

https://www.emergency.cdc.gov/han/2023/han00489.asp

WHO announced that Equatorial Guinea confirmed its first outbreak of the rare disease ... Infectious Disease > General Infectious Disease What Do We Know About Marburg Virus Disease?. - WHO announced that Equatorial ... Marburg virus disease affects both people and non-human primates, and is caused by a genetically unique animal-borne RNA virus ... The first known human cases of Marburg virus disease were reported in 1967 in Marburg and Frankfurt, Germany, and in Belgrade, ...

https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/103109

Its the first case of the Ebola-like virus in West Africa. ... but highly infectious Marburg virus disease has died in Guinea ... A patient with the rare, but highly infectious Marburg virus disease has died in Guinea, according to a World Health ... Guinea confirms West Africas first case of rare, Ebola-like Marburg virus disease ... Marburg virus was first identified in 1967, when 31 people became sick in Germany and Yugoslavia in an outbreak that was ...

https://edition.cnn.com/2021/08/10/africa/guinea-confirms-marburg-disease-intl/index.html

... no cases of Ebola virus disease or Marburg virus disease were reported in the EU/EEA. ... For 2019, no cases of Ebola virus disease or Marburg virus disease were reported in the EU/EEA. ... Ebola virus disease Ebola and Marburg haemorrhagic fevers are rare diseases but have the potential to cause high death rates. ... European Centre for Disease Prevention and Control. Ebola and Marburg virus disease. In: ECDC. Annual epidemiological report ...

https://www.ecdc.europa.eu/en/publications-data/ebola-and-marburg-virus-diseases-annual-epidemiological-report-2019

The One Health Initiative is a movement to forge co-equal, all inclusive collaborations between physicians, osteopathic physicians, veterinarians, dentists, nurses, and other scientific-health and environmentally related disciplines.

https://onehealthinitiative.com/promed/marburg-virus-disease-equatorial-guinea-03-kie-ntem-01-march-2023/

Revelation13.net: Ebola and Marburg Virus Diseases - The "Andromeda Strain"? - A New Age / Bible Prophecy / King James Bible ... Ebola and a similar virus called Marburg have surfaced in recent years in periodic outbreaks. One theory is that the Marburg ... may be carriers of the Marburg virus. This cave has been considered to be a possible source of Marburg, because two people ... Ebola, a lethal disease of Africa that kills in two weeks of infection, had its virus discovered in 1976, so if we associate ...

http://www.revelation13.net/Ebola.html

Ebola Virus Disease (EVD) and Marburg Virus Disease (MVD) are both rare but serious diseases known as viral hemorrhagic fevers ... What are Ebola Virus Disease and Marburg Virus Disease? ... What are Ebola Virus Disease and Marburg Virus Disease?. Ebola ... Virus Disease (EVD) and Marburg Virus Disease (MVD) are both rare but serious diseases known as viral hemorrhagic fevers (VHFs ... Although these are 2 different diseases caused by different viruses, the sickness they cause is similar. Because of this, the ...

https://doh.wa.gov/emergencies/be-prepared-be-safe/diseases/ebola-virus-disease-and-marburg-virus-disease

https://doh.wa.gov/ln/node/17680

Marburg virus disease outbreaks from 2000 to 2016. Peoples knowledge and attitude towards Ebola and Marburg virus disease ... that communities describe Ebola and Marburg virus diseases as very severe diseases with no cure and they believe the diseases ... Marburgvirus Marburg Virus Disease Middle Aged Public Health Social Stigma Young Adult ... People educated beyond primary school were more likely to be knowledgeable about Ebola and Marburg virus disease than those who ...

https://stacks.cdc.gov/view/cdc/53875

You must be logged in to use lightbox functionality. Please Log In or Register. ...

https://photos.hq.who.int/galleries/209

... Centers for Disease Control and Prevention (U.S.) "Marburg ... Centers for Disease Control and Prevention (U.S.) "Marburg virus disease outbreaks in Equatorial Guinea and Tanzania" , 2023. ... Title : Marburg virus disease outbreaks in Equatorial Guinea and Tanzania Corporate Authors(s) : Centers for Disease Control ... to inform clinicians and public health departments in the United States about two confirmed outbreaks of Marburg virus disease ...

https://stacks.cdc.gov/view/cdc/126616

https://tools.cdc.gov/podcasts/download.asp?m=320567&c=734469

Marburg and Ebola Virus Infections - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - ... Marburg virus disease, and WHO: Interim advice on the sexual transmission of the Ebola virus disease. ... Symptoms and Signs of Marburg and Ebola Virus Infections Symptoms of Marburg and Ebola virus infection are very similar. ... Diagnosis of Marburg and Ebola Virus Infections *. Evaluation and testing per the Centers for Disease Control and Prevention ...

https://www.msdmanuals.com/en-gb/professional/infectious-diseases/arboviruses,-arenaviridae,-and-filoviridae/marburg-and-ebola-virus-infections

In "Marburg Virus Disease", Springer-Verlag, Berlin-West. 1971. pp. 208-215.. 7. Casals, J. 1971. In "Marburg Virus Disease". ... In "Marburg Virus Disease". Springer-Verlag, Berlin-West. 1971. pp. 203-207.. 12. Tauraso, N.M., et al. 1968. Nature 218:876- ... Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Human Disease. Geographic Distribution. References. Remarks. References. History. Abbreviations. Information Exchange User ...

https://wwwn.cdc.gov/ArboCAT/VirusDetails.aspx?ID=442&SID=13

What makes the possibility of a Marburg-related infection scary is that no treatment or vaccine exists for this virus and it ... Marburg virus disease (MVD), formerly known as Marburg haemorrhagic fever, is a severe, often fatal illness in humans. ... What is Marburg virus disease? Ghana reports first case, should India be worried? Signs and symptoms of this deadly-like Ebola ... Now it seems two cases of the deadly Marburg virus have been identified in Ghana, the first time the Ebola-like disease has ...

https://www.timesnownews.com/health/what-is-marburg-virus-disease-ghana-reports-first-case-should-india-be-worried-signs-and-symptoms-of-this-deadly-like-ebola-disease-article-92827570

Since the first discovery of Marburg virus, there have been at least 14 Marburg virus disease outbreaks worldwide, with nearly ...

http://www.medscape.com/resource/ebola

CDC Marburg Site. References. *↑ Pigott DM, Golding N, Mylne A, et al. Mapping the zoonotic niche of Marburg virus disease in ... Ebola virus disease and Marburg disease in pregnancy: a review and management considerations for filovirus infection. Obstet ... Multidistrict Outbreak of Marburg Virus Disease-Uganda, 2012. J Infect Dis. 2015 Jul 23. pii: jiv351. ... Also known as Marburg hemorrhagic fever. *RNA virus of the filovirus family *The 5 species of Ebola are the other 5 members of ...

https://www.wikem.org/wiki/Marburg

Also read Marburg Virus Disease articles about how to live with Marburg Virus Disease , and more. ... Read about Marburg Virus Disease symptoms, causes, diagnosis, and treatment. ... "Marburg virus disease," World Health Organization. "Marburg hemorrhagic fever (Marburg HF)," Centers for Disease Control and ... Many of the signs and symptoms of Marburg virus disease (MVD) are non specific and are similar to those of other diseases such ...

https://feeds.rxwiki.com/condition/marburg-virus-disease

... and mode of transmission in nature of Ebola virus and the related Marburg virus are unknown. Humans have acquired the disease ... Marburg virus disease. Berlin: Springer-Verlag, 1971.. *National Institutes of Health. Guide for the care and use of laboratory ... of blood and tissues from monkeys infected in the wild by Marburg virus. Animal caretakers did not become infected (2).. The ... did not identify unusual illness compatible with Ebola virus disease in either workers or nonhuman primates. The infected ...

https://wonder.cdc.gov/wonder/prevguid/p0000272/p0000272.asp

The current list includes COVID-19, Crimean-Cong hemorrhagic fever, Ebola virus disease and Marburg virus disease, Lassa fever ... Tag Archives: Marburg virus disease. November 27, 2022. WHO Convenes Panel to Identify Priority Pathogens for Research and ... "Disease X." Disease X is included to indicate an unknown pathogen that could cause a serious international epidemic. The ... The process began on November 18 with a meeting of more than 300 scientists who will consider the evidence on over 25 virus ...

https://foodsafetytech.com/tag/marburg-virus-disease/

Marburg virus disease answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, ... disease. Accessed October 3, 2023.. Marburg virus disease. (2021). In Venes, D. (Ed.), Tabers Medical Dictionary (24th ed.). F ... disease. Marburg Virus Disease [Internet]. In: Venes DD, editors. Tabers Medical Dictionary. F.A. Davis Company; 2021. [cited ... "Marburg Virus Disease." Tabers Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Nursing Central, nursing. ...

https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/752247/all/Marburg_virus_disease?refer=true

In February and March 2023, two distinct outbreaks of Marburg virus were reported in Equatorial Guinea and Tanzania. (cdc.gov)
On February 12, 2023, clinical samples were collected from known contacts of the decedents and sent to the Institute Pasteur in Dakar, Senegal, where one sample was confirmed positive for Marburg virus by real-time polymerase chain reaction (RT-PCR). (cdc.gov)
On March 13, 2023, two additional samples collected from people in Kié-Ntem province tested positive for Marburg virus by RT-PCR performed at a CDC-supported field laboratory at the Regional Hospital of Ebibeyin. (cdc.gov)
Brazzaville/Dar es Salaam, 2 June 2023 - Tanzania today declared the end of the Marburg Virus Disease outbreak which was confirmed just over two months ago in the north-western Kagera region. (modernghana.com)
In Tanzania, teams of responders - one trained in March 2023 and another in 2022 as neighbouring Uganda battled an outbreak of Sudan Virus Disease - were instrumental in controlling the just-ended Marburg outbreak. (modernghana.com)
Rohan, H. (2023) Situational Analysis: Marburg Virus Disease in Equatorial Guinea and Tanzania. (ids.ac.uk)
Rohan, H. (2023) Analyse Situationnelle : Maladie à Virus Marburg en Guinée équatoriale et en Tanzanie. (ids.ac.uk)
The WHO announced that on February 13, 2023, Equatorial Guinea confirmed its first-ever outbreak of Marburg virus disease. (unmc.edu)
In March 2023 authorities confirmed the first known outbreak of Marburg Virus Disease (MVD) in Tanzania. (edu.au)
Today, the World Health Organization (WHO) released its latest progress report on the fight against Neglected Tropical Diseases (NTDs) entitled " Global report on neglected tropical diseases 2023 . (abujaclinics.com)

Brazzaville/Malabo - The outbreak of Marburg Virus Disease in Equatorial Guinea ended today with no new cases reported over the past 42 days after the last patient was discharged from treatment. (who.int)
Ghana announced the country's first outbreak of Marburg virus disease after two people who were not related died on June 27 and 28. (reachmd.com)
On 17 October 2017, the Ugandan Ministry of Health notified WHO of a confirmed outbreak of Marburg virus disease (MVD) in Kween district, eastern Uganda. (who.int)

Marburg was first detected in 1967, when outbreaks of hemorrhagic fever occurred simultaneously in laboratories in Marburg and Frankfurt in Germany, and in Belgrade, in what is now Serbia - in cases that were linked to African green monkeys imported from Uganda. (reachmd.com)

While outbreak-prone diseases continue to pose a major health threat in Africa, we can bank on the region's growing expertise in health emergency response to act quickly and decisively to safeguard health and avert widespread loss of life," said Dr Matshidiso Moeti, World Health Organization (WHO) Regional Director for Africa. (who.int)
In Africa, the first outbreak of Marburg was recorded in South Africa in 1975, followed by two others in Kenya in the 1980s. (who.int)
MVD is clinically indistinguishable from Ebola virus disease (EVD), and it can also easily be confused with many other diseases prevalent in Equatorial Africa, such as other viral hemorrhagic fevers, falciparum malaria, typhoid fever, shigellosis, rickettsial diseases such as typhus, cholera, gram-negative sepsis, borreliosis such as relapsing fever or EHEC enteritis. (wikipedia.org)
Most outbreaks of Marburg and Ebola virus infections have originated in sub-Saharan Central and West Africa. (msdmanuals.com)
In December 2013, a large Zaire Ebola virus outbreak began in rural Guinea (West Africa), then spread to densely populated urban regions in Guinea and to neighboring Liberia and Sierra Leone. (msdmanuals.com)
Both Marburg viruses cause clinically indistinguishable disease (MVD) and are highly lethal human pathogens that have been linked to several epidemics of haemorrhagic fever in Africa. (europa.eu)
The disease is found throughout sub-Saharan Africa and has appeared in sporadic outbreaks since its discovery. (oklahoma.gov)
The reservoir for Marburg is the Egyptian rousette bat ( Rousettus aegyptiacus) , a type of fruit bat native to Africa. (oklahoma.gov)
Public health workers learned during the 2014-15 Ebola outbreak in West Africa that lack of available treatment options kept diseased and at-risk people away from treatment centers, making disease tracking and outbreak containment more difficult. (nih.gov)
Previous outbreaks and sporadic cases of Marburg in Africa have been reported in Angola, Zimbabwe, the Democratic Republic of the Congo, Kenya, South Africa, and Uganda. (africanhealthreport.com)
Previous outbreaks and sporadic cases of Marburg have been recorded in other African countries like Angola, Zimbabwe, the Democratic Republic of the Congo, Kenya, South Africa, and Uganda. (africanhealthreport.com)
Any outbreak of Marburg is a major concern," said Dr Matshidiso Moeti, WHO Regional Director for Africa. (facetvnews.com)
The Marburg outbreak in Ghana was the second of its kind in West Africa. (facetvnews.com)
Scientists have detected Marburg virus in fruit bats in Sierra Leone, marking the first time the deadly virus has been found in West Africa. (sciencedaily.com)
The Ghana outbreak is only the second in West Africa after Guinea detected the virus last year. (cnn.com)
New outbreaks of the Marburg virus in Africa are raising concerns about disease spread and whether researchers can move in quickly to test potential vaccines. (medpagetoday.com)
These viruses started in Africa, and that is where most cases of the disease have happened. (kaiserpermanente.org)
Avoid hospitals or clinics in West Africa where the disease is being treated. (kaiserpermanente.org)
AFRICA CDC The Ministry of Health and Social Welfare (MoH) of Equatorial Guinea reported a confirmed Marburg virus disease (MVD). (topafricanews.com)
It is thought that MARV disease outbreaks in humans begin when the virus spills over from its primary animal host, which is likely to be chronically infected bats in sub-Saharan Africa. (genengnews.com)
In areas of Africa where a vaccine for Marburg is most needed, a single-dose vaccine that could protect recipients over a long period of time would be a crucial part of quelling outbreaks. (genengnews.com)

Many of the signs and symptoms of MVD are similar to other infectious diseases (such as malaria, typhoid fever, or dengue) or viral hemorrhagic fevers that may be endemic in the area (such as Lassa fever or Ebola). (cdc.gov)
Marburg virus disease is a rare but highly fatal viral hemorrhagic fever caused by two zoonotic viruses, Marburg virus and Ravn virus, that are closely related to ebolaviruses within family Filoviridae . (cdc.gov)
In August and September 1967, an outbreak of a viral hemorrhagic fever occurred among laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia (now Serbia) who were processing kidneys from African green monkeys that had been imported from Uganda. (cdc.gov)
About Marburg hemorrhagic fever [cited 2017 Mar 31]. (cdc.gov)
formerly Marburg hemorrhagic fever) is a viral hemorrhagic fever in human and non-human primates caused by either of the two Marburgviruses: Marburg virus (MARV) and Ravn virus (RAVV). (wikipedia.org)
Clinical phases of Marburg hemorrhagic fever's presentation are described below. (wikipedia.org)
Non-infectious diseases that can be confused with MVD are acute promyelocytic leukemia, hemolytic uremic syndrome, snake envenomation, clotting factor deficiencies/platelet disorders, thrombotic thrombocytopenic purpura, hereditary hemorrhagic telangiectasia, Kawasaki disease, and even warfarin intoxication. (wikipedia.org)
Marburg and Ebola viruses are filamentous filoviruses that are distinct from each other but that cause clinically similar diseases characterized by hemorrhagic fevers and capillary leakage. (msdmanuals.com)
However, in 1967, a small Marburg hemorrhagic fever outbreak occurred in Germany and Yugoslavia among laboratory workers who had been exposed to tissues from imported green monkeys. (msdmanuals.com)
Marburg can cause severe viral hemorrhagic fever, which interferes with the blood's ability to clot. (reachmd.com)
Marburg Virus Disease (MVD) is a viral hemorrhagic fever that is a part of the same family as Ebola viruses. (oklahoma.gov)
Marburg can cause severe viral hemorrhagic fever, which impairs the ability of the blood to clot. (legacyias.com)
Clinically, MVD is difficult to distinguish from diseases such as malaria, typhoid fever, and other viral hemorrhagic fevers. (legacyias.com)
Kyasanur Forest disease and Omsk HF are typical biphasic diseases with a febrile or hemorrhagic period that is often followed by CNS involvement, similar to tick-borne encephalitis (Central European encephalitis, Russian spring-summer encephalitis) except that hemorrhagic manifestations are not characteristic of the first phase of the tick-borne encephalitides. (medscape.com)
It is part of the family of viruses that causes hemorrhagic fever. (myjoyonline.com)
The presence of Marburg virus, a close relative to Ebola virus that also causes hemorrhagic disease in people, was detected in advance of any reported cases of human illness in Sierra Leone. (sciencedaily.com)
Finding Marburg virus in bats in Sierra Leone before any known cases in people is a huge success, as public health officials and doctors can now include Marburg virus among the possible causes when diagnosing hemorrhagic fever cases in the region," said Tracey Goldstein, co-principal investigator and pathogen detection lead for the PREDICT project from the UC Davis One Health Institute. (sciencedaily.com)
Marburg is a highly infectious viral hemorrhagic fever in the same family as the better known Ebola virus disease and has a fatality ratio of up to 88%, according to WHO. (cnn.com)
These are known as hemorrhagic viruses, because they can cause severe bleeding. (kaiserpermanente.org)

Human infection with Marburg virus disease initially results from prolonged exposure to mines or caves inhabited by Rousettus bat colonies. (who.int)
Raising awareness of risk factors for Marburg infection and protective measures that individuals can take is an effective way to reduce human transmission. (who.int)
The mortality, modes of infection, diagnostic tests, and treatments of Marburg virus disease: A systematic review. (nih.gov)
Ebola virus infection is slightly more virulent than Marburg virus infection. (msdmanuals.com)
It is unknown how Marburg virus first spread from animal to human, but two previous cases have shown exposure to infected bat feces or aerosols as the likely routes of infection. (oklahoma.gov)
He has also recently studied the course of infection by the highly virulent Marburg Angola virus in nonhuman primates. (nih.gov)
Scientists funded by the National Institutes of Health have found that an experimental treatment cured 100 percent of guinea pigs and rhesus monkeys in late stages of infection with lethal levels of Marburg and Ravn viruses, relatives of the Ebola virus. (nih.gov)
Prior studies of different experimental Marburg treatments involved daily dosing for 7 and 14 days, respectively, with treatment beginning closer to the time of infection. (nih.gov)
It is not yet known how the Marburg virus first spreads from its animal host to individuals, however, in 2008, for two cases in tourists visiting Uganda, unprotected contact with infected bat feces or aerosols are the most possible routes of infection. (africanhealthreport.com)
Lives have been saved and people's health protected thanks to an effective disease detection system that helped to quickly identify the virus and enabled prompt response to curb the spread of infection. (facetvnews.com)
Eleven Egyptian rousette fruit bats tested positive for active Marburg virus infection. (sciencedaily.com)
These findings indicate that filovirus outbreaks may go undetected in Uganda and people involved in artisan gold mining are more likely to be exposed to infection with either Marburg virus or ebolaviruses, likely due to increased risk of exposure to bats. (biomedcentral.com)
A person who is sick with one of these viruses can spread the infection to others. (kaiserpermanente.org)
How is an Ebola or Marburg virus infection treated? (kaiserpermanente.org)
There is no medicine that cures an Ebola or Marburg virus infection. (kaiserpermanente.org)

Marburg virus disease (MVD), formerly known as Marburg haemorrhagic fever, is a severe disease in humans caused by Marburg marburgvirus (MARV). (europa.eu)
According to Ghana Health Service, the disease was suspected following the identification of two persons who met the case definition for an Acute Haemorrhagic Fever in two different locations in the Ashanti Region. (nursesinghana.com)
Marburg Virus Disease is a rare but severe haemorrhagic fever that affects both humans and non-human primates. (nursesinghana.com)
Marburg virus disease is an extremely infectious viral haemorrhagic fever in the same family as the well-known Ebola virus disease. (africanhealthreport.com)
Marburg virus disease was previously referred to as Marburg haemorrhagic fever and is often a severe fatal illness in humans. (africanhealthreport.com)
The virus causes severe viral haemorrhagic fever in humans and was first recognised in 1967, when two large outbreaks took place at the same time in Marburg and Frankfurt in Germany, and in Belgrade, Serbia. (africanhealthreport.com)

Two large outbreaks that occurred simultaneously in Marburg and Frankfurt in Germany, and in Belgrade, Serbia, in 1967, led to the initial recognition of the disease. (who.int)
Negative contrast electron microscopy of Marburg virus, from original monkey kidney cell culture propagation done at CDC in 1967, magnification ≈40,000x. (cdc.gov)
Marburg was first recognized in 1967, when simultaneous outbreaks occurred in Marburg and Frankfurt, Germany and in Belgrade, Yugoslavia (now Serbia). (oklahoma.gov)
It was first identified in 1967 in a German City called Marburg hence its name. (myjoyonline.com)

Marburg virus (MARV) and Ravn virus (RAVV), family Filoviridae. (wikipedia.org)
There is a single species Marburg marburgvirus , that includes two viruses: Marburg and Ravn virus with approximately 20% genetic divergence [4]. (europa.eu)
Although the Marburg and Ravn viruses are less familiar than Ebola virus, both can resemble Ebola in symptoms and outcomes in people, and both lack preventive and therapeutic countermeasures. (nih.gov)
Therapeutic treatment of Marburg and Ravn virus disease in nonhuman primates with a human monoclonal antibody. (nih.gov)
These include seven EVD outbreaks caused by Sudan virus (6 outbreaks) and Bundibugyo virus (one outbreak) and four Marburg virus disease (MVD) outbreaks caused by Marburg virus and Ravn virus [ 1 ]. (biomedcentral.com)

Thanks to these efforts, Tanzania has been able to end this outbreak and limit the potentially devastating impacts of a highly infectious disease," Dr Moeti said. (modernghana.com)
Mortality is very high," said Dr. John Amuasi, who leads the global health and infectious disease research group at the Kumasi Center for Collaborative Research in Tropical Medicine in Kumasi, Ghana. (reachmd.com)
Journal of Infectious Disease. (stanford.edu)
Ghana has declared the end of an outbreak of Marburg virus, a highly infectious disease similar to Ebola. (bizcommunity.com)
The focus of this STTR phase I component is on proof-of-concept studies demonstrating applicability of technical approaches for identificationof circulatory diagnostic markers for infectious disease. (sbir.gov)

There have only been two cases of Marburg virus disease this year, both reported in Ghana. (reachmd.com)
The Ghana Health Service (GHS) in a press statement has confirmed two cases of Marburg Virus Disease (MVD) in the Ashanti Region. (nursesinghana.com)
About 522 cases of Marburg virus disease have been recorded across 11 countries since its discovery. (myjoyonline.com)
Tanzania has confirmed its first-ever cases of Marburg Virus Disease, after laboratory tests were carried out following reports of cases and deaths in the country's north-west Kagera region. (abujaclinics.com)

The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments in the United States about two confirmed outbreaks of Marburg virus disease (MVD)-one in Equatorial Guinea and one in Tanzania. (cdc.gov)
In the previous outbreaks of Marburg Virus Disease (MVD), only one US traveler was diagnosed MVD. (oklahoma.gov)

The virus-positive bats were all Egyptian rousette bats, the known reservoir for Marburg virus, which primarily feed on fruit. (sciencedaily.com)

If a person has early symptoms of MVD and a possible exposure to marburgvirus, the patient should be isolated and public health professionals notified. (cdc.gov)
Based on further analysis of ongoing research, WHO recommends that male survivors of Marburg virus disease practise safer sex and hygiene for 12 months from onset of symptoms or until their semen twice tests negative for Marburg virus. (who.int)
Its clinical symptoms are very similar to those of Ebola virus disease (EVD). (wikipedia.org)
The most detailed study on the frequency, onset, and duration of MVD clinical signs and symptoms was performed during the 1998-2000 mixed MARV/RAVV disease outbreak. (wikipedia.org)
MVD is not an airborne disease and is considered not to be contagious before symptoms appear. (europa.eu)
Survivors rarely show the most severe symptoms of the disease and may never reach the late organ phase [13]. (europa.eu)
There are no vaccines or antiviral treatments for the disease, medical experts said, but hydrating patients and treating their specific symptoms can improve their chances of survival. (reachmd.com)
The disease is clinically similar to Ebola in its spread, symptoms, and progression, although it is caused by a different virus, according to the W.H.O. In Marburg's case, fruit bats are considered to be the hosts of the virus, though researchers say it does not cause them illness. (reachmd.com)
What are the symptoms of Marburg virus disease? (reachmd.com)
According to medical experts, there are no vaccines or antiviral treatments for the disease, but hydrating patients and treating their specific symptoms can improve their chances of survival. (legacyias.com)
According to WHO, the disease is clinically similar to Ebola in its spread, symptoms, and progression, despite being caused by a different virus. (legacyias.com)
The clinical diagnosis of MVD can be tough because of the similarity in the signs and symptoms with other infectious diseases such as malaria or typhoid fever. (africanhealthreport.com)
The disease symptoms may also be similar to viral haemorrhagic fevers such as Lassa fever or Ebola. (africanhealthreport.com)
However, none of the 98 people has shown symptoms nor tested positive for the virus. (myjoyonline.com)
The first stage is characterized by a sudden onset of flu-like symptoms like high fever, general body weakness and headache, similar to other infectious diseases such as malaria, typhoid and covid-19. (myjoyonline.com)
Management of Marburg virus disease is, therefore, symptoms based. (myjoyonline.com)
The other three recovered and do not have any symptoms of the disease. (medlineplus.gov)
A person who has Ebola CANNOT spread the disease until symptoms appear. (medlineplus.gov)
A person who does not have symptoms 21 days after being exposed to Ebola will not develop the disease. (medlineplus.gov)
Health care providers will treat the symptoms of the disease. (medlineplus.gov)
Male survivors of Marburg virus disease should practice safer sexual practices and hygiene for 12 months from onset of symptoms or until their semen twice tests undetected (negative) for Marburg virus. (medicalnotes.info)
As for where Disease X could come from, nobody knows for sure, but there a multitude of possible sources, including existing viruses that demonstrate new virulence and symptoms (such as Zika virus ), engineered viruses escaped from laboratories or used as bioweapons, and zoonotic infections transferred from animals to humans. (sciencealert.com)
People infected with the virus cannot spread it until they have symptoms. (kaiserpermanente.org)
The symptoms appear suddenly from 2 to 21 days after you are exposed to the virus. (kaiserpermanente.org)
You have flu-like symptoms and you may have been exposed to the virus. (kaiserpermanente.org)
You may need to watch for symptoms and avoid exposing others to the virus. (kaiserpermanente.org)
Those diagnosed with Marburg are usually advised to drink plenty of water as doctors treat a patient's specific symptoms. (dailytrust.com)

According to the CDC, there was one case in Guinea in 2021 that resulted in death, and three of four people who had the disease in Uganda in 2017 also died. (legacyias.com)
To date, there have been 12 known outbreaks of Marburg virus with the most recent in Uganda in 2017. (sciencedaily.com)

The Marburg virus is transmitted to people from fruit bats and spreads among humans through direct contact with the bodily fluids of infected people, surfaces and materials. (who.int)
Egyptian fruit bats are believed to be the normal carrier in nature and Marburg virus RNA has been isolated from them. (wikipedia.org)
This isolation strongly suggests that Old World fruit bats are involved in the natural maintenance of marburgviruses and that visiting bat-infested caves is a risk factor for acquiring marburgvirus infections. (wikipedia.org)
Fruit bats, known to be the carriers of the virus, are common in the Ashanti region. (reachmd.com)
In the case of Marburg, fruit bats are thought to be the virus's hosts, though researchers claim the virus does not cause illness in them. (legacyias.com)
Marburg can be transmitted to individuals from continuous exposure to mines or caves inhabited by Rousettus bat colonies, fruit bats of the Pteropodidae family, are considered to be natural hosts of the Marburg virus. (africanhealthreport.com)
Fruit bats pollinate important crops, and insect-eating bats eat thousands of insects each night, including mosquitoes, which helps control pests that transmit disease and damage crops. (sciencedaily.com)
The virus is transmitted to humans from fruit bats and can then be spread human-to-human through direct contact with the bodily fluids of infected people or surfaces and materials contaminated with these fluids, WHO explained. (cnn.com)
The Ghana Health Service has urged the Ghanaian public to avoid mines and caves occupied by fruit bats and to thoroughly cook all meat products before consumption, to help reduce the risk of spreading the virus. (cnn.com)
Fruit bats are natural hosts of Marburg virus, the health service said. (cnn.com)
Marburg is transmitted to people from fruit bats and spreads between humans through bodily fluids. (dailytrust.com)

Blood samples sent to Noguchi Memorial Institute for Medical Research suggest Marburg virus. (nursesinghana.com)
Genomic sequence analyses of the Marburg virus by Senegal's Institut Pasteur and the Noguchi Memorial Institute for Medical Research in Ghana suggest that this latest outbreak is related to the case reported in Guinea in 2021. (facetvnews.com)

MVD is caused by the Marburg virus, a genetically unique zoonotic or animal-borne RNA virus of the filovirus family. (africanhealthreport.com)
How exactly do we know that this virus, SARS-CoV-2, has a "zoonotic" animal origin and not an artificial one? (theconversation.com)

Marburg, Ebole and Lassa virus infections]. (nih.gov)
The nasty viruses--Lassa, Marburg, and Ebola. (nih.gov)
A clinical guide to viral haemorrhagic fevers: Ebola, Marburg and Lassa. (nih.gov)
Swollen baby syndrome describes severe Lassa fever in infants and toddlers with anasarca, abdominal distention, and spontaneous bleeding but pediatric disease is otherwise not distinctive from that observed in older patients. (medscape.com)
It currently includes COVID-19, Ebola virus disease and Marburg virus disease, Lassa fever , Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), Nipah, Zika, and Disease X. (sciencealert.com)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
Researchers believe that Ebola is likely carried by bats or by nonhuman primates, according to the Centers for Disease Control and Prevention. (reachmd.com)
Marburg virus was detected by projects led by the Centers for Disease Control and Prevention, the USAID-funded PREDICT project led by the One Health Institute at the UC Davis School of Veterinary Medicine, Njala University, Sierra Leone and the University of Makeni, Sierra Leone. (sciencedaily.com)
For the most up-to-date news about Ebola or Marburg outbreaks, check the U.S. Centers for Disease Control and Prevention (CDC) website (www.cdc.gov/vhf/ebola or www.cdc.gov/vhf/marburg) or call them at 800-CDC-INFO (800-232-4636). (kaiserpermanente.org)
Check the U.S. Centers for Disease Control and Prevention (CDC) website (www.cdc.gov/vhf/ebola or www.cdc.gov/vhf/marburg). (kaiserpermanente.org)

The Marburg virus is the pathogen that causes Marburg virus disease in humans, health experts said. (reachmd.com)
Code-named 'Disease X', this mystery pathogen hasn't even been discovered yet, but the looming threat of its almost certain inevitability has secured it a place on the WHO's 'most dangerous' list: a catalogue of potential future epidemics for which countermeasures are insufficient - or don't exist at all. (sciencealert.com)
Disease X represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease," the WHO explained in a recent statement . (sciencealert.com)
This year, for the first time, the WHO added Disease X to the list, in an acknowledgment of the fact it's highly probable another pathogen will soon be added to this record - and by increasing awareness of that probability, it may actually boost research efforts to combat the imminent, unknown, threat. (sciencealert.com)
They will also consider the so-called "Disease X" - an unknown pathogen that could cause a serious international epidemic . (sciencealert.com)

Bats are reservoir hosts of several high-impact viruses that cause significant human diseases, including Nipah virus, Marburg virus and rabies virus. (mdpi.com)
Bats were also the source of the viruses causing Ebola, rabies, Nipah and Hendra virus infections, Marburg virus disease, and strains of Influenza A virus. (theconversation.com)

Two people infected with the virus died in Ghana last month, though no other cases were found, experts said. (reachmd.com)
For now, health researchers in Ghana and in other parts of the world said that there was no indication that the virus had spread further. (reachmd.com)
The people who contracted the virus were not related and they were in different parts of the Ashanti region of Ghana, Dr. Amuasi said. (reachmd.com)
Ghana declared the country's first Marburg virus disease outbreak after two unrelated people died. (legacyias.com)
Recently, the disease was detected in the Southern Ashanti region of Ghana. (africanhealthreport.com)
Ghana is racing against time to contain the outbreak of one of the highly lethal viruses in human history. (myjoyonline.com)
Two people in the southern part of Ghana tested positive for the Marburg virus. (myjoyonline.com)
Ghana and Guinea are the only two west African countries with recorded cases of this deadly virus. (myjoyonline.com)
Accra/Brazzaville - Ghana today declared the end of the Marburg virus disease outbreak that was confirmed nearly two months ago. (facetvnews.com)
Ghana has confirmed its first two cases of the highly infectious Marburg virus disease, the World Health Organization (WHO) said Sunday in a statement . (cnn.com)
The announcement comes after two unrelated patients from the southern Ashanti region of Ghana, both of whom later died, tested positive for the virus. (cnn.com)
Ghana has reported two suspected cases of Marburg virus as the fear of possible outbreak heightened, the BBC reports. (dailytrust.com)
Plans are in place to conduct further trials of the cAd3-Marburg vaccine in Ghana, Kenya, Uganda, and the United States. (genengnews.com)

Marburg virus in Egyptian Rousettus bats in Guinea: Investigation of Marburg virus outbreak origin in 2021. (nih.gov)

Overview of Arbovirus, Arenavirus, and Filovirus Infections Arbovirus (arthropod-borne virus) is defined as any virus that is transmitted to humans and/or other vertebrates by certain species of blood-feeding arthropods, mostly insects (flies and mosquitoes). (msdmanuals.com)
The six species of the Ebola virus are the only other known members of the filovirus family. (africanhealthreport.com)
Marburg and Ebola viruses are both members of the Filoviridae family (filovirus). (medicalnotes.info)
Among all participants, filovirus seropositivity was 2.6% (19/724) of which 2.3% (17/724) were reactive to Sudan virus only and 0.1% (1/724) to Marburg virus. (biomedcentral.com)
Marburg, a filovirus closely related to Ebola, can be transmitted via semen up to 12 weeks after clinical recovery ( 1 ). (stanford.edu)
MARV, a filovirus (the same family as Ebola virus), causes a rapidly progressive febrile illness that leads to shock and death in a large proportion of infected individuals. (genengnews.com)

Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review. (nih.gov)
This brief provides an overview of the Marburg Virus Disease outbreaks in Equatorial Guinea and Tanzania, as well as contextual factors to inform considerations for responses in both countries. (ids.ac.uk)

Once an individual gets infected with the virus, it spreads among humans through direct contact with the blood, secretions, organs, or other bodily fluids of infected people, and with contaminated surfaces and materials. (africanhealthreport.com)
Marburg spreads through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials (e.g. bedding, clothing) contaminated with these fluids. (medicalnotes.info)
However, COVID-19 is a new disease and we are still learning about how it spreads and the severity of illness it causes. (snohd.org)

Even though it has not spread widely, Marburg has been deadly, with case fatality rates ranging from 24 to 88 percent, depending on which strain people contract and the management of cases, according to the W.H.O.The Ebola case fatality rates are nearly the same. (reachmd.com)
MVD is a severe, often deadly disease that affects both humans and non-human primates (such as monkeys, gorillas, and chimpanzees). (oklahoma.gov)
The news of a new outbreak of a deadly disease caused by viral infections heightened the concerns of a public already exhausted by the coronavirus pandemic and alarmed by the spread of monkeypox and a new case of polio. (legacyias.com)
Despite the fact that it has not spread widely, Marburg has been deadly, with case fatality rates ranging from 24 percent to 88 percent, according to WHO, depending on which strain people contract and how cases are managed. (legacyias.com)
Marburg's fatality rate, which measures how deadly the disease can be, varies. (myjoyonline.com)
Ebola is a severe and often deadly disease caused by a virus. (medlineplus.gov)
Ebola and Marburg virus diseases are rare but often deadly diseases that are caused by the Ebola or Marburg virus. (kaiserpermanente.org)
Ebola is a deadly disease caused by a virus. (mountsinai.org)

Unfortunately, there is no treatment, cure or approved vaccine for the Marburg Virus disease. (myjoyonline.com)
If you work in health care or a laboratory and you work with Ebola patients or the Ebola virus, you may be able to get the Ebola vaccine. (kaiserpermanente.org)
There is currently no vaccine or treatment for the disease. (dailytrust.com)
An experimental vaccine against Marburg virus (MARV) was found to be safe and induced an immune response in a small, first-in-human clinical trial. (genengnews.com)
The vaccine, developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), could become an important tool to respond to Marburg virus outbreaks. (genengnews.com)
This first-in-human, Phase I study tested an experimental MARV vaccine candidate, known as cAd3-Marburg, which was developed at NIAID's Vaccine Research Center (VRC). (genengnews.com)
This vaccine uses a modified chimpanzee adenovirus called cAd3, which can no longer replicate or infect cells, and displays a glycoprotein found on the surface of MARV to induce immune responses against the virus. (genengnews.com)
The cAd3 vaccine platform demonstrated a good safety profile in prior clinical trials when used in investigational Ebola virus and Sudan virus vaccines developed by the VRC. (genengnews.com)
If additional data support the promising results seen in the Phase I trial, the cAd3-Marburg virus vaccine could someday be used in emergency responses to MARV outbreaks. (genengnews.com)

And there's no asymptomatic Marburg. (reachmd.com)
There are also indications that patients may be able to spread the virus while pre-symptomatic or asymptomatic. (snohd.org)

It was the country's first outbreak of the disease. (modernghana.com)

Cell and tissue tropism and virus‑cell membrane fusion are determined by MARV GP. (europa.eu)
No approved vaccines or specific therapies are available for MARV disease, aside from supportive care. (genengnews.com)

Ebola and Marburg infections occur from unknown sources, but links to primates and contact with other infected humans are observed. (medscape.com)

Clinical diagnosis of Marburg virus disease (MVD) can be difficult. (cdc.gov)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
Because of its similitude with other infectious diseases, clinical diagnosis in the early stages can be challenging and requires a very high index of suspicion. (myjoyonline.com)
Marburg virus transmission via infected semen has been documented up to seven weeks after clinical recovery. (medicalnotes.info)
The health authorities, with support from World Health Organization (WHO) and other health partners, swiftly rolled out outbreak control measures, stepping up disease surveillance, testing, contact-tracing, clinical care as well as raising public awareness and working with communities to support disease prevention efforts. (facetvnews.com)
He is an Associate Professor in the School of Public Health, Tropical Medicine & Rehabilitation Sciences at James Cook University, Townsville, Queensland, and a specialist Clinical Microbiologist and Infectious Diseases Physician, who holds specialist qualifications in pathology (microbiology), internal medicine (infectious diseases), public health and tropical medicine. (edu.au)
He also holds a position as Clinical Senior Lecturer in Infectious Diseases at Sydney University. (edu.au)

These outbreaks mark the first time that Marburg virus has been identified in either Equatorial Guinea or Tanzania, though the virus has been identified previously in neighboring countries and the reservoir, the Egyptian fruit bat, is known to be present in both countries. (cdc.gov)
As is usual with reservoir hosts, these viruses apparently cause little or no pathology in bats. (mdpi.com)

The Ebola -Sudan Virus Disease (SVD) outbreak in Uganda was confirmed by health authorities on September 20, 2022. (unmc.edu)
Uganda has experienced seven Ebola Virus Disease (EVD) outbreaks and four Marburg Virus Disease (MVD) outbreaks between 2000 and 2019. (biomedcentral.com)
We investigated the seroprevalence and risk factors for Marburg virus and ebolaviruses in gold mining communities around Kitaka gold mine in Western Uganda and compared them to non-mining communities in Central Uganda. (biomedcentral.com)
In September 2022 an Ebola Virus outbreak was reported from Uganda, and is ongoing as at late November/early December 2022 with deaths including some in health care workers. (edu.au)

The national health authorities with support from World Health Organization (WHO) and partner organizations immediately rolled out outbreak response to stop the spread of the virus and save lives. (modernghana.com)
According to a new status report from the World Health Organization (WHO), five billion people globally remain unprotected from harmful trans fat, increasing their risk of heart disease and death. (abujaclinics.com)

More than 200 people died in an outbreak in Angola from 2004 to 2005 and more than 100 died of the disease in the Democratic Republic of Congo from 1998 to 2000, according to the C.D.C. Other outbreaks of Marburg have not involved as many cases. (reachmd.com)
According to the CDC, more than 200 people died in an outbreak in Angola from 2004 to 2005, and more than 100 died of the disease in Congo from 1998 to 2000. (legacyias.com)

Viruses in the genera Ebolavirus and Marburgvirus belong to the family Filoviridae and cause classical viral haemorrhagic fevers (VHFs) in humans, which are associated with high morbidity and mortality and pose a serious threat to human and animal populations in endemic countries. (biomedcentral.com)

MVD in humans is a notifiable disease at the EU/EEA level [2]. (europa.eu)
They also harbor many other viruses that are thought to have caused disease in humans after spillover into intermediate hosts, including SARS and MERS coronaviruses. (mdpi.com)
These challenges can be addressed, in part, with new technologies that are species-independent that can provide insight into the interactions of bats and viruses, which should clarify how the viruses persist in nature, and what risk factors might facilitate transmission to humans and livestock. (mdpi.com)
As the ecosystem and human habitats change there is always the risk of disease jumping from animals to humans," Rottingen said . (sciencealert.com)
But the vast majority of scientists who have studied the virus agree that it evolved naturally and crossed into humans from an animal species, most likely a bat. (theconversation.com)
An estimated 60% of known infectious diseases and 75% of all new, emerging, or re-emerging diseases in humans have animal origins . (theconversation.com)
Or an initially harmless form of the virus might have jumped directly into humans and then evolved to become harmful as it passed between people. (theconversation.com)

Este informe proporciona una imagen global de los brotes de la enfermedad por el virus de Marburg en Guinea Ecuatorial y Tanzania, así como los factores coyunturales a tener en cuenta para implementar medidas de respuesta en ambos países. (ids.ac.uk)

In total, three confirmed cases, including two deaths were recorded in the outbreak declared on 7 July 2022 after laboratory confirmation of the virus that affected the country's Ashanti, Savannah and Western regions. (facetvnews.com)
Since the end of August 2022, CDC sentinel surveillance sites for respiratory pathogens have been reporting increases in enterovirus D-68 (EV-D68) respiratory disease. (snohd.org)

Rabies is one of the most fatal diseases but can be prevented by avoiding contact with wild animals, maintenance of high immunization rates in. (mdedge.com)

The incubation period for the disease is two (2) to twenty-one (21) days. (nursesinghana.com)

According to health organisations, a patient's condition can be confirmed as Marburg by using antibody, antigen, and polymerase chain reaction tests. (legacyias.com)

It is in the same family as the virus that causes Ebola virus disease. (who.int)
Contrary to Ebola virus disease (EVD), which has been associated with heavy rains after long periods of dry weather, triggering factors for spillover of marburgviruses into the human population have not yet been described. (wikipedia.org)

Word of a new outbreak of a lethal disease caused by viral infections added to the concerns of a public weary from battling the coronavirus pandemic, and recently alarmed by the spread of monkeypox and a new case of polio. (reachmd.com)
How can India ensure better disease management based on the lessons learned from the Covid Pandemic? (legacyias.com)
In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. (sbir.gov)
Targeting priority pathogens and virus families for research and development of countermeasures is essential for a fast and effective epidemic and pandemic response," said WHO emergencies director Michael Ryan . (sciencealert.com)

Four patients recovered from the virus and have been enrolled in a survivors programme to receive psychosocial and other post-recovery support. (who.int)
Additionally, with partners, WHO shipped nearly three tons of supplies of personal protective equipment and is also working with the Ministry of Health to support survivors of the disease. (modernghana.com)
All Marburg survivors and their sexual partners should receive counselling to ensure safer sexual practices until their semen has twice tested negative for Marburg virus. (medicalnotes.info)
Male Marburg survivors should be enrolled in semen testing programmes when discharged (starting with counselling) and offered semen testing when mentally and physically ready, within three months of disease onset. (medicalnotes.info)
Having tested undetected (negative), survivors can safely resume normal sexual practices with minimized risk of Marburg virus transmission. (medicalnotes.info)
Until such time as their semen has twice tested undetected (negative) for Marburg, survivors should practice good hand and personal hygiene by immediately and thoroughly washing with soap and water after any physical contact with semen, including after masturbation. (medicalnotes.info)

Five of the new strains identified among the Marburg-positive bats in Sierra Leone were genetically similar to the strain that caused the outbreak in Angola. (sciencedaily.com)
If the virus had been genetically engineered in a lab there would be signs of manipulation in the genome data. (theconversation.com)
It is very unlikely that any techniques used to genetically engineer the virus would not leave a genetic signature , like specific identifiable pieces of DNA code. (theconversation.com)

Infected bats shed the virus in their saliva, urine and feces. (sciencedaily.com)
People may be exposed to Marburg virus through bat bites as they catch the bats. (sciencedaily.com)
Researchers and government officials met with community members to present their findings, answer questions about Marburg virus, and address how to reduce people's risk of exposure and live safely with bats. (sciencedaily.com)
Killing and coming into direct contact with bats can actually increase the risk of virus transmission, not halt it. (sciencedaily.com)
The answers lie in the genetic material and evolutionary history of the virus, and understanding the ecology of the bats in question. (theconversation.com)
Coronaviruses and bats are locked in an evolutionary arms race in which the viruses are constantly evolving to evade the bat immune system and bats are evolving to withstand infections from coronaviruses. (theconversation.com)
A virus will evolve multiple variants, most of which will be destroyed by the bat's immune system, but some will survive and pass to other bats. (theconversation.com)

What are the hosts for the Marburg virus? (legacyias.com)

Both diseases are rare and have the capacity to cause dramatic outbreaks with high fatality rates. (medicalnotes.info)

Marburg viruses are filamentous, enveloped, single-stranded, negative-sense RNA viruses that belong to the family Filoviridae , genus Marburgvirus . (europa.eu)

Marburg is a frightening disease as it is highly infectious and lethal. (facetvnews.com)

Most marburgvirus infections were repeatedly associated with people visiting natural caves or working in mines. (wikipedia.org)
Infections have occurred in other parts of the world when people with the disease traveled there. (kaiserpermanente.org)

A new virus, named Marburg virus, was isolated from patients and monkeys, and the high case-fatality ratio called for the best biocontainment of the day ( Figure ). (cdc.gov)
Agent of disease contracted from green monkeys. (cdc.gov)
Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory. (stanford.edu)

Although the outbreak has ended, WHO is continues to work with Equatorial Guinea to maintain measures such as surveillance and testing to enable prompt action should flare-ups of the virus occur, with the training provided during the outbreak helping to strengthen readiness capacity. (who.int)
According to the WHO, last year, one case of the disease was also confirmed in Guinea, however, the outbreak was declared over on 16 September 2021, five weeks after the initial case was identified. (africanhealthreport.com)
The patient in the Guinea outbreak also died from the virus. (cnn.com)

Resurgence of Marburg can occur and WHO is working with Ghana's health authorities to maintain surveillance and improve detection and response to potential flare-up of the virus. (facetvnews.com)

Marburg Virus Disease has a fatality ratio of up to 88 per cent depending on virus strain and the quality of case management. (africanhealthreport.com)
The average Marburg virus fatality ratio is about 90% (475 deaths/522 cases). (myjoyonline.com)

Organisms4

Diseases5

Geographicals1

Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. (1/99)

Viewpoint: filovirus haemorrhagic fever outbreaks: much ado about nothing? (2/99)

Enzyme-linked immunosorbent assays for detection of antibodies to Ebola and Marburg viruses using recombinant nucleoproteins. (3/99)

VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment. (4/99)

Immunoglobulin M and G responses measured by immunofluorescence in patients with Lassa or Marburg virus infections. (5/99)

Short communication: a cluster of Marburg virus disease involving an infant. (6/99)

Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes. (7/99)

Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. (8/99)

Marburg Virus Disease

Marburgvirus

Filoviridae

Ebolavirus

Hemorrhagic Fevers, Viral

Filoviridae Infections

Hemorrhagic Fever, Ebola

Virus Diseases

Ross River virus

Democratic Republic of the Congo

Distinct mechanisms of entry by envelope glycoproteins of Marburg and Ebola (Zaire) viruses. (1/99)

Viewpoint: filovirus haemorrhagic fever outbreaks: much ado about nothing? (2/99)

Enzyme-linked immunosorbent assays for detection of antibodies to Ebola and Marburg viruses using recombinant nucleoproteins. (3/99)

VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment. (4/99)

Immunoglobulin M and G responses measured by immunofluorescence in patients with Lassa or Marburg virus infections. (5/99)

Short communication: a cluster of Marburg virus disease involving an infant. (6/99)

Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes. (7/99)

Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. (8/99)

Marburg virus disease

2023 Marburg virus disease outbreak in Tanzania

2022 Marburg virus disease outbreak in Ghana

2021 Marburg virus disease outbreak in Guinea

2023 Marburg virus disease outbreak in Equatorial Guinea

Marburg virus

1967 Marburg virus outbreak

2017 Uganda Marburg virus outbreak

Marburgvirus

Pelger-Huët anomaly

Jane Aceng

MHF (disambiguation)

List of Ebola outbreaks

Plague of Athens

2023 in Equatorial Guinea

Kitum Cave

William Bazeyo

Bleeding

Ravn virus

Nsok-Nsomo

Uíge Province

Megabat

Orientale Province

MRNA vaccine

Filoviridae

BioCryst Pharmaceuticals

1998 in the Democratic Republic of the Congo

Remdesivir

Prevention of viral hemorrhagic fever

Haut-Uele District

Prevention | Marburg (Marburg Virus Disease) | CDC

Marburg virus disease in Uganda | PAGNet

Health Alert Network (HAN) - 00489 | Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

Etymologia: Marburg Virus - Volume 23, Number 10-October 2017 - Emerging Infectious Diseases journal - CDC

WHO EMRO | Marburg virus disease | Thèmes de santé

Marburg virus disease - Wikipedia

Health Alert Network (HAN) - 00489 | Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

What Do We Know About Marburg Virus Disease? | MedPage Today

Marburg virus disease: Guinea confirms West Africa's first case of rare, Ebola-like disease | CNN

Ebola and Marburg virus diseases - Annual Epidemiological Report for 2019

MARBURG VIRUS DISEASE - EQUATORIAL GUINEA (03): (KIE-NTEM) 01 March 2023 - One Health Initiative

Ebola and Marburg Virus Diseases - A New Age / Bible Prophecy / King James Bible Code Analysis

Ebola Virus Disease and Marburg Virus Disease | Washington State Department of Health

Ebola Virus Disease and Marburg Virus Disease | Washington State Department of Health

Knowledge and attitude towards Ebola and Marburg virus diseases in Uganda using quantitative and participatory epidemiology...

WHO Photo Library - Gallery - Marburg virus disease

Marburg virus disease outbreaks in Equatorial Guinea and Tanzania

Health Alert Network (HAN) - 00489 | Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania

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202310

Outbreak of Marburg virus d3

Detected in 19671

Africa21

Hemorrhagic19