Disorders of the mediastinum, general or unspecified.
Tumors or cancer of the MEDIASTINUM.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
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General or unspecified injuries to the chest area.
A complication of multiple rib fractures, rib and sternum fractures, or thoracic surgery. A portion of the chest wall becomes isolated from the thoracic cage and exhibits paradoxical respiration.
Pressure, burning, or numbness in the chest.
Rib fractures are breaks or cracks in the rib bones, which can occur at any location along the rib's length, often caused by direct trauma or severe coughing, and may result in pain, difficulty breathing, and increased risk of complications such as pneumonia.
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Hemorrhage within the pleural cavity.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Tumors or cancer of the LUNG.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

Idiopathic azygos vein aneurysm: a rare cause of mediastinal mass. (1/157)

Venous aneurysm of the azygos arch is a very rare cause of mediastinal mass and is usually an incidental finding on chest radiography. Nowadays the diagnosis is made by non-invasive tests such as thoracic CT scanning and/or magnetic resonance imaging. The case is described of an asymptomatic woman in whom a mediastinal mass due to an azygos vein aneurysm was diagnosed by non-invasive procedures, the aetiology of which, in all probability, was idiopathic.  (+info)

Mediastinal fibromatosis presenting with superior vena cava syndrome. (2/157)

We encountered a fatal case of mediastinal fibromatosis in a 67-year-old female in whom there was aggressive infiltration into the large vessels, nerves and pericardium. She presented with the superior vena cava syndrome, Horner's syndrome, paralysis of bilateral vocal cords and diaphragm and heart failure. Mediastinoscopical examination revealed an extremely firm tumor adhering to the sternum, trachea and brachiocephalic artery. She died of severe heart failure due to the disturbed dilatation of the heart and ventilatory insufficiency. Although mediastinal fibromatosis is very uncommon and sometimes difficult to diagnose at an early stage, physicians should be aware of this disease for the differential diagnosis of mediastinal tumors.  (+info)

Spontaneous oesophageal perforation due to mediastinal tuberculous lymphadenitis - atypical presentation of tuberculosis. (3/157)

Spontaneous non-traumatic oesophageal perforation secondary to bursting of a mediastinal tuberculous abscess into the oesophagus is rare. The diagnosis is delayed, as perforation remains localised due to mediastinal lymph nodes. Patient can be effectively managed by paraoesophageal drainage of the mediastinal abscess and oesophageal diversion.  (+info)

Recurrent laryngeal nerve palsy associated with mediastinal amyloidosis. (4/157)

Amyloidosis affecting peripheral nerves causing isolated nerve palsies is uncommon. Localised amyloidosis occurs less frequently than the reactive or immune related systemic forms, and mediastinal localisation is virtually unknown. We present a case of recurrent laryngeal nerve palsy associated with mediastinal AL amyloidosis in a middle aged man.  (+info)

Transient mediastinal enlargement: an unusual computed tomographic manifestation of pulmonary venous hypertension and congestive heart failure. (5/157)

We describe a case of diffuse superior and middle mediastinal enlargement of soft tissue attenuation noted on helical computed tomography (CT) of a patient with clinical and radiographic findings of congestive heart failure (CHF). Upon treatment and improvement of his pulmonary venous hypertension, a repeat CT scan revealed resolution of the mediastinal abnormalities. We, therefore, advocate a search for primary CT signs of CHF in patients with findings of widespread mediastinal distension. If present, repeat CT scanning after resolution of the cardiac condition should be performed before further intervention for the mediastinal abnormality is attempted.  (+info)

Bronchopulmonary and mediastinal leishmaniasis: an unusual clinical presentation of Leishmania donovani infection. (6/157)

We describe a case of unusual leishmaniasis in a Sudanese man with a history of progressively enlarging granulomatous mediastinal lymphadenopathy, worsening hemoptysis, and an intense mucosal granulomatous inflammatory response in the large bronchi. Leishmania donovani DNA was detected in bronchial biopsies by polymerase chain reaction. This is a novel description of human leishmanial infection in an immunocompetent patient involving this anatomical site. The patient's condition improved clinically, spirometrically, and radiologically after a course of treatment with amphotericin B. The cell-mediated immune response was analyzed before, during, and after successful antileishmanial chemotherapy.  (+info)

Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation. (7/157)

To determine the role of mediastinal shift after pneumonectomy (PNX) on compensatory responses, we performed right PNX in adult dogs and replaced the resected lung with a custom-shaped inflatable silicone prosthesis. Prosthesis was inflated (Inf) to prevent mediastinal shift, or deflated (Def), allowing mediastinal shift to occur. Thoracic, lung air, and tissue volumes were measured by computerized tomography scan. Lung diffusing capacities for carbon monoxide (DL(CO)) and its components, membrane diffusing capacity for carbon monoxide (Dm(CO)) and capillary blood volume (Vc), were measured at rest and during exercise by a rebreathing technique. In the Inf group, lung air volume was significantly smaller than in Def group; however, the lung became elongated and expanded by 20% via caudal displacement of the left hemidiaphragm. Consequently, rib cage volume was similar, but total thoracic volume was higher in the Inf group. Extravascular septal tissue volume was not different between groups. At a given pulmonary blood flow, DL(CO) and Dm(CO) were significantly lower in the Inf group, but Vc was similar. In one dog, delayed mediastinal shift occurred 9 mo after PNX; both lung volume and DL(CO) progressively increased over the subsequent 3 mo. We conclude that preventing mediastinal shift after PNX impairs recruitment of diffusing capacity but does not abolish expansion of the remaining lung or the compensatory increase in extravascular septal tissue volume.  (+info)

An unusual case of mediastinal lymphadenopathy caused by amyloidosis. (8/157)

A 71-year-old Japanese female Nagasaki-atomic-bomb survivor was admitted for evaluation of a mediastinal mass. She was infected with human T-cell leukemia virus type I. Histological examination of the biopsy specimen, obtained thoracoscopically from the mass, revealed amyloid lymphadenopathy confirmed by Congo-red staining and electron-microscopic examination. Amyloid deposits and the serum monoclonal peak consisted of immunoglobulin lambda light chains. No atypical cells were detected in bone marrow. The case was diagnosed as an unusual amyloidosis affecting the mediastinal lymph node. No other sites were found to be affected by amyloidosis, although systemic involvement could not be conclusively ruled out.  (+info)

Mediastinal diseases refer to a group of conditions that affect the mediastinum, which is the area in the chest separating the lungs and containing various vital structures such as the heart, esophagus, trachea, thymus gland, lymph nodes, blood vessels, and nerves. These diseases can be benign or malignant (cancerous) and may cause symptoms due to compression or invasion of surrounding tissues. Examples of mediastinal diseases include:

1. Mediastinal tumors: Abnormal growths in the mediastinum, which can be benign or malignant. Common types include thymomas, germ cell tumors, lymphomas, and neurogenic tumors.
2. Mediastinitis: Inflammation of the mediastinal tissues, often caused by infections, trauma, or complications from medical procedures.
3. Enlarged lymph nodes: Abnormal swelling of the lymph nodes in the mediastinum can be a sign of various conditions, including infections, cancer, and autoimmune disorders.
4. Mediastinal cysts: Fluid-filled sacs that develop in the mediastinum, which are usually benign but may cause symptoms due to compression or infection.
5. Aneurysms or dissections of the aorta: Abnormal weakening or tearing of the aortic wall within the mediastinum, which can lead to life-threatening complications if not treated promptly.
6. Esophageal diseases: Conditions affecting the esophagus, such as tumors, strictures, or motility disorders, may present with symptoms related to the mediastinum.
7. Thyroid disorders: Enlargement of the thyroid gland (goiter) can extend into the mediastinum and cause compression symptoms.
8. Hematomas or effusions: Accumulation of blood (hematoma) or fluid (effusion) in the mediastinal space due to trauma, surgery, or other underlying conditions.

Early diagnosis and appropriate treatment are crucial for managing mediastinal diseases and improving patient outcomes.

Mediastinal neoplasms refer to abnormal growths or tumors located in the mediastinum, which is the central compartment of the thoracic cavity that lies between the lungs and contains various vital structures such as the heart, esophagus, trachea, blood vessels, lymph nodes, and nerves. Mediastinal neoplasms can be benign (non-cancerous) or malignant (cancerous), and they can arise from any of the tissues or organs within the mediastinum.

Benign mediastinal neoplasms may include thymomas, lipomas, neurofibromas, or teratomas, among others. These tumors are typically slow-growing and rarely spread to other parts of the body. However, they can still cause symptoms or complications by compressing adjacent structures within the mediastinum, such as the airways, blood vessels, or nerves.

Malignant mediastinal neoplasms are cancerous tumors that can invade and destroy surrounding tissues and may spread (metastasize) to other parts of the body. Common types of malignant mediastinal neoplasms include thymic carcinomas, lymphomas, germ cell tumors, and neuroendocrine tumors. These tumors often require aggressive treatment, such as surgery, radiation therapy, and chemotherapy, to control their growth and spread.

It is important to note that mediastinal neoplasms can present with various symptoms depending on their location, size, and type. Some patients may be asymptomatic, while others may experience cough, chest pain, difficulty breathing, hoarseness, or swallowing difficulties. A thorough diagnostic workup, including imaging studies and biopsies, is necessary to confirm the diagnosis and determine the best course of treatment for mediastinal neoplasms.

Mechlorethamine is an antineoplastic agent, which means it is used to treat cancer. It is a type of alkylating agent, which is a class of drugs that work by interfering with the DNA of cancer cells, preventing them from dividing and growing. Mechlorethamine is used in the treatment of Hodgkin's lymphoma and non-Hodgkin's lymphoma, as well as some other types of cancer. It can be administered intravenously or topically (as a cream) to treat skin lesions caused by certain types of cancer.

Mechlorethamine is a potent drug that can have significant side effects, including nausea, vomiting, hair loss, and an increased risk of infection due to suppression of the immune system. It can also cause damage to the heart, lungs, and reproductive system with long-term use. As with all chemotherapy drugs, mechlorethamine should be administered under the close supervision of a healthcare professional.

Hodgkin disease, also known as Hodgkin lymphoma, is a type of cancer that originates in the white blood cells called lymphocytes. It typically affects the lymphatic system, which is a network of vessels and glands spread throughout the body. The disease is characterized by the presence of a specific type of abnormal cell, known as a Reed-Sternberg cell, within the affected lymph nodes.

The symptoms of Hodgkin disease may include painless swelling of the lymph nodes in the neck, armpits, or groin; fever; night sweats; weight loss; and fatigue. The exact cause of Hodgkin disease is unknown, but it is thought to involve a combination of genetic, environmental, and infectious factors.

Hodgkin disease is typically treated with a combination of chemotherapy, radiation therapy, and/or immunotherapy, depending on the stage and extent of the disease. With appropriate treatment, the prognosis for Hodgkin disease is generally very good, with a high cure rate. However, long-term side effects of treatment may include an increased risk of secondary cancers and other health problems.

MedlinePlus is not a medical term, but rather a consumer health website that provides high-quality, accurate, and reliable health information, written in easy-to-understand language. It is produced by the U.S. National Library of Medicine, the world's largest medical library, and is widely recognized as a trusted source of health information.

MedlinePlus offers information on various health topics, including conditions, diseases, tests, treatments, and wellness. It also provides access to drug information, medical dictionary, and encyclopedia, as well as links to clinical trials, medical news, and patient organizations. The website is available in both English and Spanish and can be accessed for free.

Thoracic injuries refer to damages or traumas that occur in the thorax, which is the part of the body that contains the chest cavity. The thorax houses vital organs such as the heart, lungs, esophagus, trachea, and major blood vessels. Thoracic injuries can range from blunt trauma, caused by impacts or compressions, to penetrating trauma, resulting from stabbing or gunshot wounds. These injuries may cause various complications, including but not limited to:

1. Hemothorax - bleeding into the chest cavity
2. Pneumothorax - collapsed lung due to air accumulation in the chest cavity
3. Tension pneumothorax - a life-threatening condition where trapped air puts pressure on the heart and lungs, impairing their function
4. Cardiac tamponade - compression of the heart caused by blood or fluid accumulation in the pericardial sac
5. Rib fractures, which can lead to complications like punctured lungs or internal bleeding
6. Tracheobronchial injuries, causing air leaks and difficulty breathing
7. Great vessel injuries, potentially leading to massive hemorrhage and hemodynamic instability

Immediate medical attention is required for thoracic injuries, as they can quickly become life-threatening due to the vital organs involved. Treatment may include surgery, chest tubes, medications, or supportive care, depending on the severity and type of injury.

Flail chest is a serious injury to the thorax characterized by a segment of the chest wall that moves paradoxically in relation to the rest of the chest wall during respiration. This occurs due to multiple rib fractures at two or more places, resulting in a free-floating section of the chest wall that is not connected to the sternum or spine.

During inspiration, when the chest normally expands, the flail segment moves inward, and during expiration, it moves outward, which can lead to significant impairment of ventilation and oxygenation. Flail chest can result from high-impact trauma such as motor vehicle accidents or falls, and it is often associated with underlying lung contusions or other injuries. It requires immediate medical attention and may necessitate mechanical ventilation and surgical stabilization of the rib cage to prevent complications such as pneumonia and respiratory failure.

Chest pain is a discomfort or pain that you feel in the chest area. The pain can be sharp, dull, burning, crushing, heaviness, or tightness. It may be accompanied by other symptoms such as shortness of breath, sweating, nausea, dizziness, or pain that radiates to the arm, neck, jaw, or back.

Chest pain can have many possible causes, including heart-related conditions such as angina or a heart attack, lung conditions such as pneumonia or pleurisy, gastrointestinal problems such as acid reflux or gastritis, musculoskeletal issues such as costochondritis or muscle strain, and anxiety or panic attacks.

It is important to seek immediate medical attention if you experience chest pain that is severe, persistent, or accompanied by other concerning symptoms, as it may be a sign of a serious medical condition. A healthcare professional can evaluate your symptoms, perform tests, and provide appropriate treatment.

Rib fractures are breaks or cracks in the bones that make up the rib cage, which is the protective structure around the lungs and heart. Rib fractures can result from direct trauma to the chest, such as from a fall, motor vehicle accident, or physical assault. They can also occur from indirect forces, such as during coughing fits in people with weakened bones (osteoporosis).

Rib fractures are painful and can make breathing difficult, particularly when taking deep breaths or coughing. In some cases, rib fractures may lead to complications like punctured lungs (pneumothorax) or collapsed lungs (atelectasis), especially if multiple ribs are broken in several places.

It is essential to seek medical attention for suspected rib fractures, as proper diagnosis and management can help prevent further complications and promote healing. Treatment typically involves pain management, breathing exercises, and, in some cases, immobilization or surgery.

Nonpenetrating wounds are a type of trauma or injury to the body that do not involve a break in the skin or underlying tissues. These wounds can result from blunt force trauma, such as being struck by an object or falling onto a hard surface. They can also result from crushing injuries, where significant force is applied to a body part, causing damage to internal structures without breaking the skin.

Nonpenetrating wounds can cause a range of injuries, including bruising, swelling, and damage to internal organs, muscles, bones, and other tissues. The severity of the injury depends on the force of the trauma, the location of the impact, and the individual's overall health and age.

While nonpenetrating wounds may not involve a break in the skin, they can still be serious and require medical attention. If you have experienced blunt force trauma or suspect a nonpenetrating wound, it is important to seek medical care to assess the extent of the injury and receive appropriate treatment.

Hemothorax is a medical condition characterized by the presence of blood in the pleural space, which is the area between the lungs and the chest wall. This accumulation of blood can occur due to various reasons such as trauma, rupture of a blood vessel, or complications from lung or heart surgery.

The buildup of blood in the pleural space can cause the affected lung to collapse, leading to symptoms such as shortness of breath, chest pain, and cough. In severe cases, hemothorax can be life-threatening if not promptly diagnosed and treated. Treatment options may include chest tube drainage, blood transfusion, or surgery, depending on the severity and underlying cause of the condition.

A carcinoid tumor is a type of slow-growing neuroendocrine tumor that usually originates in the digestive tract, particularly in the small intestine. These tumors can also arise in other areas such as the lungs, appendix, and rarely in other organs. Carcinoid tumors develop from cells of the diffuse endocrine system (also known as the neuroendocrine system) that are capable of producing hormones or biologically active amines.

Carcinoid tumors can produce and release various hormones and bioactive substances, such as serotonin, histamine, bradykinins, prostaglandins, and tachykinins, which can lead to a variety of symptoms. The most common syndrome associated with carcinoid tumors is the carcinoid syndrome, characterized by flushing, diarrhea, abdominal cramping, and wheezing or difficulty breathing.

Carcinoid tumors are typically classified as functional or nonfunctional based on whether they produce and secrete hormones that cause symptoms. Functional carcinoid tumors account for approximately 30% of cases and can lead to the development of carcinoid syndrome, while nonfunctional tumors do not produce significant amounts of hormones and are often asymptomatic until they grow large enough to cause local or distant complications.

Treatment options for carcinoid tumors depend on the location, size, and extent of the tumor, as well as whether it is functional or nonfunctional. Treatment may include surgery, medications (such as somatostatin analogs, chemotherapy, or targeted therapies), and radiation therapy. Regular follow-up with imaging studies and biochemical tests is essential to monitor for recurrence and assess treatment response.

Neuroendocrine tumors (NETs) are a diverse group of neoplasms that arise from cells of the neuroendocrine system, which is composed of dispersed neuroendocrine cells throughout the body, often in close association with nerves and blood vessels. These cells have the ability to produce and secrete hormones or hormone-like substances in response to various stimuli. NETs can occur in a variety of organs, including the lungs, pancreas, small intestine, colon, rectum, stomach, and thyroid gland, as well as in some less common sites such as the thymus, adrenal glands, and nervous system.

NETs can be functional or nonfunctional, depending on whether they produce and secrete hormones or hormone-like substances that cause specific symptoms related to hormonal excess. Functional NETs may give rise to a variety of clinical syndromes, such as carcinoid syndrome, Zollinger-Ellison syndrome, pancreatic neuroendocrine tumor syndrome (also known as Verner-Morrison or WDHA syndrome), and others. Nonfunctional NETs are more likely to present with symptoms related to the size and location of the tumor, such as abdominal pain, intestinal obstruction, or bleeding.

The diagnosis of NETs typically involves a combination of imaging studies, biochemical tests (e.g., measurement of serum hormone levels), and histopathological examination of tissue samples obtained through biopsy or surgical resection. Treatment options depend on the type, location, stage, and grade of the tumor, as well as the presence or absence of functional symptoms. They may include surgery, radiation therapy, chemotherapy, targeted therapy, and/or peptide receptor radionuclide therapy (PRRT).

Lung neoplasms refer to abnormal growths or tumors in the lung tissue. These tumors can be benign (non-cancerous) or malignant (cancerous). Malignant lung neoplasms are further classified into two main types: small cell lung carcinoma and non-small cell lung carcinoma. Lung neoplasms can cause symptoms such as cough, chest pain, shortness of breath, and weight loss. They are often caused by smoking or exposure to secondhand smoke, but can also occur due to genetic factors, radiation exposure, and other environmental carcinogens. Early detection and treatment of lung neoplasms is crucial for improving outcomes and survival rates.

Practice guidelines, also known as clinical practice guidelines, are systematically developed statements that aim to assist healthcare professionals and patients in making informed decisions about appropriate health care for specific clinical circumstances. They are based on a thorough evaluation of the available scientific evidence, consensus of expert opinion, and consideration of patient preferences. Practice guidelines can cover a wide range of topics, including diagnosis, management, prevention, and treatment options for various medical conditions. They are intended to improve the quality and consistency of care, reduce unnecessary variations in practice, and promote evidence-based medicine. However, they should not replace clinical judgment or individualized patient care.

Neoplasm staging is a systematic process used in medicine to describe the extent of spread of a cancer, including the size and location of the original (primary) tumor and whether it has metastasized (spread) to other parts of the body. The most widely accepted system for this purpose is the TNM classification system developed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC).

In this system, T stands for tumor, and it describes the size and extent of the primary tumor. N stands for nodes, and it indicates whether the cancer has spread to nearby lymph nodes. M stands for metastasis, and it shows whether the cancer has spread to distant parts of the body.

Each letter is followed by a number that provides more details about the extent of the disease. For example, a T1N0M0 cancer means that the primary tumor is small and has not spread to nearby lymph nodes or distant sites. The higher the numbers, the more advanced the cancer.

Staging helps doctors determine the most appropriate treatment for each patient and estimate the patient's prognosis. It is an essential tool for communication among members of the healthcare team and for comparing outcomes of treatments in clinical trials.

Guideline adherence, in the context of medicine, refers to the extent to which healthcare professionals follow established clinical practice guidelines or recommendations in their daily practice. These guidelines are systematically developed statements designed to assist practitioners and patient decisions about appropriate health care for specific clinical circumstances. Adherence to evidence-based guidelines can help improve the quality of care, reduce unnecessary variations in practice, and promote optimal patient outcomes. Factors that may influence guideline adherence include clinician awareness, familiarity, agreement, self-efficacy, outcome expectancy, and the complexity of the recommendation.

Carcinoma, neuroendocrine is a type of cancer that arises from the neuroendocrine cells, which are specialized cells that have both nerve and hormone-producing functions. These cells are found throughout the body, but neuroendocrine tumors (NETs) most commonly occur in the lungs, gastrointestinal tract, pancreas, and thyroid gland.

Neuroendocrine carcinomas can be classified as well-differentiated or poorly differentiated based on how closely they resemble normal neuroendocrine cells under a microscope. Well-differentiated tumors tend to grow more slowly and are less aggressive than poorly differentiated tumors.

Neuroendocrine carcinomas can produce and release hormones and other substances that can cause a variety of symptoms, such as flushing, diarrhea, wheezing, and heart palpitations. Treatment for neuroendocrine carcinoma depends on the location and extent of the tumor, as well as the patient's overall health. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches.

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... intestinal and mediastinal diseases must be absent. MRI and ultrasound also have characterictic findings. Skin biopsy is ... This disease affects more men than women. After onset, the disease stabilizes after about 5-20 years. Life of PDP patients can ... such as cardiopulmonary diseases, malignancies or paraneoplastic syndrome). Unlike SHO, PDP does not have an underlying disease ... PDP is a rare genetic disease. At least 204 cases of PDP have been reported. The precise incidence and prevalence of PDP are ...
... hyaline-vascular variant of Castleman's disease, Rosai-Dorfman disease, Kawasaki disease, Kimura disease Benign lymphadenopathy ... Mediastinal lymphadenopathy Bilateral hilar lymphadenopathy Dermatopathic lymphadenopathy: lymphadenopathy associated with skin ... "Eosinophilic lung disease complicated by Kimura's disease: a case report and literature review". Internal Medicine (Tokyo, ... Lymphadenopathy of more than 1.5-2 cm increases the risk of cancer or granulomatous disease as the cause rather than only ...
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Castleman, B.; Iverson, L.; Menendez, V. P. (July 1956). "Localized mediastinal lymphnode hyperplasia resembling thymoma". ... Castleman disease is named after Benjamin Castleman, who first described the disease in 1956. The Castleman Disease ... Whether Castleman disease should be considered an autoimmune disease, cancer, or infectious disease is currently unknown. ... Diseases other than Castleman disease can present with similar histologic findings in lymph node tissue, including: Infectious ...
"Whipple Disease Revealed by Lung Involvement". Chest. 141 (6): 1595-8. doi:10.1378/chest.11-1812. PMID 22670021. v t e (Medical ... Mediastinal lymphadenopathy or mediastinal adenopathy is an enlargement of the mediastinal lymph nodes. There are many possible ... Silicone mediastinal lymphadenopathy. Lymphadenopathy Mediastinum Mediastinal lymph node Mediastinal mass Neoplasia ... which has migrated and collected in mediastinal lymph nodes. ...
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... or mediastinal diseases or other possible causes of the symptoms often seen with LP. Some vets may also recommend running a ... However, the disorder may arise secondary to general neuropathies, generalized neuromuscular diseases, muscular diseases, ... If medical therapy is unsuccessful and surgery cannot be performed due to concurrent disease (such as heart or lung problems) ... or cost, euthanasia may be necessary if the animal's quality of life is considered unacceptable due to the disease. Stanley BJ ...
Castleman, B.; Iverson, L.; Menendez, V. P. (July 1956). "Localized mediastinal lymphnode hyperplasia resembling thymoma". ... Castleman disease is named after Benjamin Castleman, who first described the disease in 1956. The Castleman Disease ... World Castleman Disease Day was established in 2018 and is held every year on July 23.[citation needed] The Castleman Disease ... Unicentric Castleman disease is a subtype of Castleman disease (also known as giant lymph node hyperplasia, lymphoid hamartoma ...
In Europe, this disease is exceptionally rare. More cases are seen in USA where the disease may often be associated with ... Lymphatic organ diseases, Autosomal recessive disorders, All stub articles, Respiratory disease stubs). ... Mediastinal fibrosis is characterized by invasive, calcified fibrosis centered on lymph nodes that block major vessels and ... Mitchell IM, Saunders NR, Maher O, Lennox SC, Walker DR (1986). "Surgical treatment of idiopathic mediastinal fibrosis: report ...
Castleman, B.; Iverson, L.; Menendez, V. P. (July 1956). "Localized mediastinal lymphnode hyperplasia resembling thymoma". ... Castleman disease was named after Dr. Benjamin Castleman, who first described the disease in 1956. The Castleman Disease ... but not to pre-disease baseline Stable disease - Improvement in at least 1 (but not all) symptoms Progressive disease - ... Diseases that must be excluded in the diagnosis of iMCD include infectious diseases, such as HHV-8-associated MCD, Epstein-Barr ...
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... heart disease), lungs (lung disease), and other pleural or mediastinal structures. In most countries, cardiothoracic surgery is ... If there is no evidence of undue shortness of breath or diffuse parenchymal lung disease, and the FEV1 exceeds 2 litres or 80% ... The first attempts to palliate congenital heart disease were performed by Alfred Blalock with the assistance of William ... Gang Hou (30 December 2015). "Bronchoscopic lung volume reduction in chronic obstructive pulmonary disease:History and progress ...
... as a result of diffuse mediastinal lymphadenopathy of various pathologies such as cystic fibrosis and Castleman's disease. Park ... 2008). "Giant mass due to Castleman's disease causing superior vena cava syndrome". Thorac Cardiovasc Surg. 56 (5): 303-305. ... 1997). "Superior vena cava obstruction secondary to mediastinal lymphadenopathy in a patient with cystic fibrosis". Chest. 112 ...
... disease; (2) Teratoma and cyst. Many signs and symptoms of a mediastinal tumor do not distinguish between these two principal ... The most common mediastinal masses are neurogenic tumors (20% of mediastinal tumors), usually found in the posterior ... There is also primary mediastinal B-cell lymphoma with exceptionally good prognosis. Common symptoms of a mediastinal lymphoma ... of cases are mediastinal large B cell lymphomas. In several editions of Physical Diagnosis, concerning mediastinal tumors the ...
... as the disease progresses. Mediastinal lymphadenopathy and bronchiectasis may also be seen. Precise distribution and types of ... It can take many years of exposure to cause BFL, with an average of 1.6 years to cause acute disease, and 16 years to cause ... Pulmonary fibrosis is generally the most serious consequence of the disease, as it progressively and irreversibly diminishes ... Corticosteroids, such as prednisone, often suppresses symptoms temporarily, especially in the early stages of the disease. ...
... and mediastinal pleura. The number and size varies. Pleural plaques are typically asymptomatic, however, there is still some ... Asbestos-related diseases are disorders of the lung and pleura caused by the inhalation of asbestos fibres. Asbestos-related ... People who worked in jobs with high asbestos dust exposure are at the highest risk of developing asbestos-related disease. ... Thus asbestos-related pleural diseases can result from much lower doses than the fibrotic changes in the lung. Pleural plaques ...
370 Gene expression profiling shows considerable variance from other DLBCLs and similarity to Hodgkin disease.: 290-293 PMLBCL ... 2011). "Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray ... Primary mediastinal (thymic) large B-cell lymphoma is a distinct type of diffuse large B-cell lymphoma involving the ... Despite 80% PMLBCL being stage I or II, the presenting anterior mediastinal mass is often over 10 cm and is locally invasive of ...
... mediastinal fibrosis and some cases of retroperitoneal fibrosis. This is not a complete list, as IgG4-RD can involve any site ... related disease: an orphan disease with many faces". Orphanet Journal of Rare Diseases. 9: 110. doi:10.1186/s13023-014-0110-z. ... IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition ... IgG4-related ophthalmic disease IgG4-related prostatitis IgG4-related skin disease Wallace, Zachary S.; Deshpande, Vikram; ...
... interstitial lung diseases and sarcoidosis. Coughing can also be triggered by benign or malignant lung tumors or mediastinal ... In healthy children it may be normal in the absence of any disease to cough ten times a day. The most common cause of an acute ... A healthy adult also coughs 18.8 times a day on average, but in the population with respiratory disease the geometric mean ... Cardiovascular diseases associated with cough are heart failure, pulmonary infarction and aortic aneurysm. Nocturnal cough is ...
They are now considered to be manifestations of IgG4-related disease. Brooks, MS; Robinson, JA (1985). "Idiopathic ... Known manifestations include retroperitoneal fibrosis, mediastinal fibrosis and Riedel's thyroiditis. ... October 2012). "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". ...
... etoposide and cisplatin for either three or four 21-day treatment cycles depending on the location of any metastatic disease. ... The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. In addition to ... Mediastinitis Mediastinal fibrosis Mediastinum Alan Sandler (1997). "Mediastinal Germ Cell Tumors". Semin Respir Crit Care Med ... However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with ...
... iatrogenic disease MeSH C23.550.291.906 - rare diseases MeSH C23.550.291.937 - recurrence MeSH C23.550.325.250 - mediastinal ... disease progression MeSH C23.550.291.687 - disease susceptibility MeSH C23.550.291.687.500 - genetic predisposition to disease ... acute disease MeSH C23.550.291.250 - catastrophic illness MeSH C23.550.291.500 - chronic disease MeSH C23.550.291.562 - ... MeSH C23.550.291.687.500.500 - anticipation, genetic MeSH C23.550.291.750 - diseases in twins MeSH C23.550.291.781 - ...
The onset of his disease was somewhat hidden and slowly progressed, he self-diagnosed himself with "mediastinal lymphoma" and ... In the medical series, 109 are classified under internal diseases and treatment, 62 are pharmacodynamics, and 36 are the ...
... cleft lip corpus callosum lipoma skin polyps Median nodule of the upper lip Mediastinal endodermal sinus tumors Mediastinal ... This is a list of diseases starting with the letter "M". Diseases Alphabetical list 0-9 A B C D E F G H I J K L M N O P Q R S T ... Mitochondrial diseases of nuclear origin Mitochondrial diseases, clinically undefinite Mitochondrial disease Mitochondrial ... disease Marchiafava-Micheli disease Marcus Gunn phenomenon Marden-Walker-like syndrome Marden-Walker syndrome Marek disease ...
CT scans may show characteristic findings such as ground-glass opacities in centrilobular distribution, and mediastinal ... PVOD may occur in patients with associated diseases such as HIV, bone marrow transplantation, and connective tissue diseases. ... Chloe Temtchine, American singer-songwriter with PVOD "Pulmonary venoocclusive disease , Genetic and Rare Diseases Information ... The disease is progressive and fatal, with median survival of about 2 years from the time of diagnosis to death. The definitive ...
pulmonary over-inflation syndrome Pulmonary barotrauma of ascent related diseases. Lung over-pressure injury which may manifest ... as arterial gas embolism, pneumothorax, tension pneumothorax, mediastinal emphysema, subcutaneous emphysema or occasionally ... Centers for Disease Control and Prevention. 64 (19): 518-521. PMC 4584570. PMID 25996093. Retrieved 26 January 2017. "How it ...
... diffuse M9678/3 Primary effusion lymphoma M9679/3 Mediastinal large B-cell lymphoma (C38.3) Mediastinal (thymic) large cell ... M9762/3 Heavy chain disease, NOS Alpha heavy chain disease Mu heavy chain disease Gamma heavy chain disease Franklin disease ... Paget disease of breast M8541/3 Paget disease and infiltrating duct carcinoma of breast (C50._) M8542/3 Paget disease, ... M9768/1 T-gamma lymphoproliferative disease M9769/1 Immunoglobulin deposition disease Systemic light chain disease Primary ...
"Mediastinal Diseases" by people in Harvard Catalyst Profiles by year, and whether "Mediastinal Diseases" was a major or minor ... "Mediastinal Diseases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Mediastinal Diseases" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Mediastinal Diseases". ...
Find symptoms and other information about Mediastinal endodermal sinus tumors. ... About Mediastinal endodermal sinus tumors. Many rare diseases have limited information. Currently GARD aims to provide the ... People with a disease may participate to receive the newest possible treatment and additional care from clinical study staff as ... People with a disease may participate to receive the newest possible treatment and additional care from clinical study staff as ...
Diagnostic accuracy of chest radiography in detecting mediastinal lymphadenopathy in suspected pulmonary tuberculosis ... Diagnostic accuracy of chest radiography in detecting mediastinal lymphadenopathy in suspected pulmonary tuberculosis ... Diagnostic accuracy of chest radiography in detecting mediastinal lymphadenopathy in suspected pulmonary tuberculosis ...
It is typically employed when there is a suspicion of certain diseases or conditions, such as lung cancer, lymphoma, infections ... This enables direct visualization of the mediastinal structures and allows us to obtain tissue samples from the lymph nodes and ... Schmetterer is known for treating Venous Disease, including varicose veins. Additionally specializing in Thoracic, Arterial, ...
Health management and winning practice articles, value-based healthcare, healthcare events, company and product directory, I-I-I videos and I-I-I blog interviews.
The unusual finding of extensive mediastinal disease raised the possibility that the patient had inhalational melioidosis. The ... Emerging Infectious Diseases. 2015;21(11):2052-2054. doi:10.3201/eid2111.141802.. APA. Currie, B. J., Price, E. P., Mayo, M., ... Use of Whole-Genome Sequencing to Link Burkholderia pseudomallei from Air Sampling to Mediastinal Melioidosis, Australia On ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
Surgical resection of mediastinal ectopic thyroid tissue: a case series ...
Heart diseases. *Mediastinal diseases, which are tumors, inflammation, and other problems with the structures in the ... ClinicalTrials.gov: Mediastinal Diseases (National Institutes of Health) * ClinicalTrials.gov: Rib Fractures (National ... ClinicalTrials.gov: Thoracic Diseases (National Institutes of Health) * ClinicalTrials.gov: Thoracic Injuries (National ... Tests for Lung Disease (National Heart, Lung, and Blood Institute) Also in Spanish ...
As such, vascular lesions of the mediastinum can be mistaken for, or misinterpreted as, one of these more common mediastinal ... Most mediastinal masses seen on thoracic imaging are of solid tumor origin. ... Mediastinal Diseases / diagnosis* * Mediastinum / blood supply* * Pulmonary Artery / abnormalities * Pulmonary Veins / ... Most mediastinal masses seen on thoracic imaging are of solid tumor origin. As such, vascular lesions of the mediastinum can be ...
Mediastinal Diseases: thymic tumors, myasthenia gravis • Mesothelioma: cancer within the lining around the lung related to ... People with lung, esophagus or chest disease who entrust their care to Virtua receive expert treatment from board-certified and ... Giant Bullous Disease: large air pockets in the surface of the lung ...
Locoregional disease: Surgical resection including mediastinal lymphadenectomy. * Metastatic or unresectable disease: Options ... Asymptomatic unresectable disease: For select patients with low tumor burden and stable disease, consider observation with ... NCCN treatment recommendations for metastatic disease are as follows:. * Observation for clinically indolent disease with ... For nonresectable tumors, locally advanced or metastatic disease, the key recommendations include the following [21, 22] :. * ...
Intracellular bacteria in Hodgkin s disease and sclerosing mediastinal B-cell lymphoma: sign of a bacterial etiology? * ...
Mediastinal lymphadenopathy is usually a sign of serious underlying disease. More than 95% of mediastinal masses are caused by ... Infectious Diseases Society of America, Infectious Diseases Society of New York, International Society for Infectious Diseases ... In children older than 6 years, Hodgkin disease and non-Hodgkin lymphoma both predominate. Children with Hodgkin disease ... Generalized lymphadenopathy is an important manifestation of the lipid storage diseases. In Niemann-Pick disease, sphingomyelin ...
Once it crosses the mediastinal midline, it denotes more advanced, surgically unresectable disease. Lung cancer can also spread ... For example, if clinical staging reveals stage IIIB or IV disease, surgery is not helpful and no pathological staging ... and the options largely depend on the stage of the disease. The underlying purpose is to describe the extent or severity of an ... mediastinal pleura, or pericardium; T3centr: Primary tumor is ... which constitutes the most advanced stage of the disease called ...
Metastatic Bone Disease. Multiple Endocrine Neoplasia Type 2 (MEN 2). Multiple Myeloma ...
Surgery for lung diseases. *Surgery for mediastinal diseases. *Minimally invasive thoracic surgery ...
THAKKAR MS, KOEGELENBERG CFN, BEZUIDENHOUT J, IRUSEN E. Mediastinal mass and hydatid disease. QJM-An International Journal of ... Journal of Infectious Diseases 2013; 207(S2): S49-S56.. *JACOBS P, WOOD L, ARMITAGE J. Molecular advances come of age (part II ... The Journal of Infectious Diseases 2013; 207(2): S101 - S106.. *HECKMAN MG, SOTO-ORTOLAZA AI, AASLY JO, ABAHUNI N, ANNESI G, ... BLANCKENBERG J, BARDIEN S, GLANZMANN B, OKUBADEJO NU, CARR J. The prevalence and genetics of Parkinsons disease in sub-Saharan ...
Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, ... Disease-induced changes in plant microbiome assembly and functional adaptation. Gao M, Xiong C, Gao C, Tsui CKM, Wang MM, Zhou ... Elevated Serum Small Dense Low-Density Lipoprotein Cholesterol May Increase the Risk and Severity of Coronary Heart Disease and ...
Ceron L, Michieletto L, Pagan V, Zamperlin A: Transbronchial needle aspiration in patients with mediastinal and hilar disease. ... Type of Disease. Out of eight studies that evaluated the type of disease as the predictor, seven reported higher sensitivity ... aPulmonary Diseases Unit, Department of Immunoallergic and Respiratory Diseases, Azienda Ospedaliero Universitaria Ospedali ... aPulmonary Diseases Unit, Department of Immunoallergic and Respiratory Diseases, Azienda Ospedaliero Universitaria Ospedali ...
Locoregional disease: Surgical resection including mediastinal lymphadenectomy. * Metastatic or unresectable disease: Options ... Asymptomatic unresectable disease: For select patients with low tumor burden and stable disease, consider observation with ... NCCN treatment recommendations for metastatic disease are as follows:. * Observation for clinically indolent disease with ... For nonresectable tumors, locally advanced or metastatic disease, the key recommendations include the following [21, 22] :. * ...
Newer therapeutic options are still needed for the disease, to minimize complications and to improve the treatment of patients ... what prognostic factors provide information that can affect treatment choices in patients with advanced disease, and what we ... addressing such issues as which patients with early-stage disease may require radiotherapy, ... physicians continue to face dilemmas in therapy for the disease, and many cured patients live with complications of treatment. ...
Thoracic positron emission tomography using 18F-fluorodeoxyglucose for the evaluation of residual mediastinal Hodgkin disease. ... or nonsecretory disease, both high-risk entities for poorly differentiated, aggressive disease. As with malignant lymphoma, ... Myeloma and bone disease: "the dangerous tango." Clin Adv Hematol Oncol. 2006;4:300-306. ... Advanced MRI, 18F-FDG PET/CT, and 99mTc-sestimibi imaging of patients with MM and related diseases are useful and reliable ...
Treatment of advanced-stage massive mediastinal Hodgkins disease: the case for combined modality treatment.Longo D, Russo A, ... Hodgkins disease in childhood.Young R, DeVita V, Johnson R. Hodgkins disease in childhood. Blood 1973, 42: 163-74. PMID: ... Hodgkins DiseaseWood A, DeVita V, Hubbard S. Hodgkins Disease. New England Journal Of Medicine 1993, 328: 560-565. PMID: ... The cure of Hodgkins disease with drugs.DeVita V, Hubbard S, Moxley J. The cure of Hodgkins disease with drugs. Advances In ...
After partial resection of the tumor the histology indicated Hodgkin's disease-mixed cellularity. The boy received ... s disease with atypical clinical presentation, laboratory data and imaging studies as well as an increased radiosensitivity. ... "Cardiac injury as late toxicity of mediastinal radiation therapy for Hodgkins disease patients," Hematologica, vol. 81, no. 2 ... Hodgkins Disease with Atypical Clinical Presentation, Associated with Ataxia-Telangiectasia. M. I. Spasova. ,1I. S. Ivanov. ,1 ...
Pleural diseases , Lung malignancies , Lung Cancer Screening , Pulmonary infections , Mediastinal diseases , Aortic diseases , ... Outpatient imaging for acute or chronic diseases , Diffuse lung diseases , Airway diseases: Bronchiectasis and Small airway ... Coronary artery disease , Coronary artery bypass graft patency , Heart failure , Myocardial disease; infiltrative diseases, ... Magnetic Resonance Imaging (MRI) is occasionally used for more advanced problem solving and mediastinal diseases or in younger ...
Indications may include pleural effusion, pericardial effusion, mediastinal disease, abnormal radiographic findings, biopsies ... Improve your diagnosis of ear disease: treat the cause, not the symptoms. *Increases client satisfaction and compliance while ... New dimensions for minimally invasive diagnosis of joint diseases at minimal risk. *Facilitates diagnostic arthroscopy with ...
830-page book.) * McReynolds 1976 (Richard A. et al), "Coronary Heart Disease after Mediastinal Irradiation for Hodgkins ... disease (coronary artery disease) in the USA. * From these conclusions plus the fact that x-ray harm is approximately ... making death from an age-related disease (cancer or heart disease) more likely" (Arvid Zuber, Ph.D., April 15, 2000, in a ... ischemic heart disease), appendicitis, strokes, chronic nephritis, diabetes mellitus, hypertensive disease, influenza and ...
The researchers enrolled patients with completely resected disease and mediastinal N2 involvement (Abstract LBA3). ... Mansoor Raza Mirza, MD, on Endometrial Cancer: Palbociclib Plus Letrozole in ER-Positive Disease Mansoor Raza Mirza, MD, of ... Erika P. Hamilton, MD, on Breast Cancer: Abemaciclib With or Without Tamoxifen in HR-Positive, HER2-Negative Metastatic Disease ...
Discover a novel method for managing compromised airway in mediastinal masses. Learn about the success of subcutaneous ... "Respiratory Obstruction Associated with Induction of General Anesthesia in a Patient with Mediastinal Hodgkins Disease," ... Clinical features: A 42 year- old, 62 Kg man was presented for an open biopsy of a middle mediastinal mass. The patient had a ... M. H. Goh, X. Y. Liu and Y. S. Goh, "Anterior Mediastinal Masses: An Anesthetic Challenge," Anesthesia, Vol. 54, No. 7, 1999, ...
Follow within 3 weeks with ISRT 36 Gy in patients with stage 1-2 bulky mediastinal disease or bulky disease ,10 cm; for ... Stages I-II unfavorable, nonbulky disease [1, 4, 6] : * ABVD regimen for two cycles (initially with staging and additional ABVD ... Stage IA-IIA disease can be treated with the ABVD regimen for up to six cycles, or with the Stanford regimen for two cycles (ie ... 17, 18] : 1.8 mg/kg IV infused over 30 min q3wk; continue treatment, not to exceed 16 cycles, or until disease progression or ...
  • When Do Symptoms of Mediastinal endodermal sinus tumors Begin? (nih.gov)
  • D. C. Strollo, M. L. Rosado-de-Christenson, and J. R. Jett, "Primary mediastinal tumors-part II: tumors of the middle and posterior mediastinum," Chest , vol. 112, no. 5, pp. 1344-1357, 1997. (hindawi.com)
  • Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
  • Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
  • To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
  • Data were gathered from a PubMed search of peer-reviewed literature on mediastinal tumors. (allenpress.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • Available at: https://www.ctsnet.org/article/surgical-management-primary-mediastinal-germ-cell-tumors. (epnet.com)
  • Available at: https://www.brighamandwomens.org/lung-center/diseases-and-conditions/germ-cell-tumors. (epnet.com)
  • This enables direct visualization of the mediastinal structures and allows us to obtain tissue samples from the lymph nodes and other areas within the mediastinum. (schmetterermd.com)
  • A computed tomography scan ( Figure 1 , panel B) confirmed the mass to be a 7-cm × 6-cm loculated fluid collection in the anterior mediastinum contiguous with patchy bilateral pneumonia and associated with multiple enlarged mediastinal lymph nodes and a pericardial effusion. (cdc.gov)
  • Cervical mediastinoscopy is the "gold standard" for mediastinal staging but is invasive and limited in assessing the posterior subcarinal, lower mediastinal, and hilar lymph nodes. (medpagetoday.com)
  • Without my even asking, he gave me a preliminary diagnosis of sarcoid (inflammatory disease) or small cell lung cancer, due to the fact my lymph nodes were not like this on my June scan. (cancer.org)
  • Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment. (bvsalud.org)
  • Approximately one third of patients have enlarged hilar or mediastinal lymph nodes. (cdc.gov)
  • Among other findings, following inhalation exposure to Indium-tin Oxide (ITO) animal studies have revealed hyperplasia of mediastinal lymph nodes and granulomas of mediastinal nodes and bronchus-associated lymphoid tissue. (cdc.gov)
  • This study aims to introduce an optimized method named "non-grasping en bloc mediastinal lymph node dissection (MLND)" through video-assisted thoracoscopic surgery (VATS). (medscape.com)
  • The staging of these patients starts with radiographic imaging -- typically with integrated PET/CT -- and in most cases, in the absence of distant metastatic disease, mediastinal staging is often critical for determining surgical candidacy. (medpagetoday.com)
  • Metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. (drugs.com)
  • This could be due to primary lung neoplasm, inflammatory process such as sarcoidosis, lymphoma, or metastatic disease. (cancer.org)
  • Metastatic disease occurs in 16% of all RMS cases and has a poor prognosis. (bvsalud.org)
  • Invited Commentary: New Paradigm for Imaging Evaluation of Pediatric Mediastinal Masses-ITMIG Classification System. (harvard.edu)
  • Mediastinal Masses (Merck & Co., Inc. (medlineplus.gov)
  • Most mediastinal masses seen on thoracic imaging are of solid tumor origin. (nih.gov)
  • As such, vascular lesions of the mediastinum can be mistaken for, or misinterpreted as, one of these more common mediastinal masses. (nih.gov)
  • This article stresses the importance of considering vascular entities in the differential diagnosis of mediastinal masses. (nih.gov)
  • Transbronchial needle aspiration (TBNA) is a safe and useful sampling technique for the diagnosis of mediastinal adenopathies/masses, but its accuracy seems to be influenced by selected clinical and procedural aspects. (karger.com)
  • The role of transbronchial needle aspiration (TBNA) for the diagnosis of mediastinal adenopathies/masses, as well as for lung cancer staging, is well established. (karger.com)
  • Purpose: Anesthesia and airway management for mediastinal masses are challenging and are accompanied by mortality and morbidity. (scirp.org)
  • Avoiding the loss of airway muscular tone in mediastinal masses has been confirmed necessary to avoid airway collapse. (scirp.org)
  • Conclusion: Owing to the characteristics of the "subcutaneous dissociative conscious sedation" this method is suggested as an appropriate substitute to general anesthesia for Endobronchial Double Lumen Intubation in mediastinal masses and compromised airway. (scirp.org)
  • M. Javid, M. Rahim and S. Rafiian, "Subcutaneous Dissociative Conscious Sedation (sDCS) a New Approach to Compromised Airway in Mediastinal Masses," Open Journal of Anesthesiology , Vol. 2 No. 4, 2012, pp. 166-169. (scirp.org)
  • The lymphoblasts infiltrate nodal structures or extranodal structures and is commonly associated with large mediastinal masses with a high predilection for disseminating to bone marrow and the central nervous system (CNS). (medscape.com)
  • The radiologist's impression reads "interval development of extensive hyper metabolic and pathologically enlarged hilar/mediastinal adenopathy. (cancer.org)
  • Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial. (nih.gov)
  • Extramedullary disease is typically an aggressive, poorly differentiated form of MM that confers inferior outcome, with median survival of less than 1 y if present at diagnosis. (snmjournals.org)
  • He suffered recurrent pulmonary infections and succumbed to severe pneumonia with respiratory failure and pulmonary hypertension five years after the diagnosis of malignant lymphoma without evidence of recurrence of Hodgkin's disease. (hindawi.com)
  • Utilizing the latest in minimally invasive surgical techniques, sometimes known as "camera" surgery, our integrated teams include doctors trained in diagnosis, surgery, pathology (disease) and oncology (cancer). (swedish.org)
  • 9-14 However, the reports to date have not always provided clear clinical evidence supporting the diagnosis of sarcoidosis nor have they excluded patients with prior tuberculous disease or infection. (bmj.com)
  • Because the early signs are non-specific, it is important to consider the diagnosis early in any patient with known TB exposure, infection, or disease, including past TB, and in all persons with compatible symptoms from high TB-burden locations. (msdmanuals.com)
  • identify other tests that can assist with diagnosis of beryllium-related diseases. (cdc.gov)
  • Overview of Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked. (merckmanuals.com)
  • Idiopathic interstitial pneumonia should be suspected in any patient with unexplained interstitial lung disease. (merckmanuals.com)
  • Rarely, there has also been evidence of interstitial lung disease, such as sarcoidosis, pulmonary fibrosis, and bronchiolitis obliterans. (cdc.gov)
  • A 31-Year-Old Man With Fever, Atypical Chest Pain, and Mediastinal Mass. Chest. (harvard.edu)
  • People with lung, esophagus or chest disease who entrust their care to Virtua receive expert treatment from board-certified and fellowship-trained thoracic surgeons who specialize in minimally invasive procedures. (virtua.org)
  • This includes radiation to the chest or thorax (including mantle, mediastinal and/or axillary treatments fileds), abdomen, spine or total body irradiation (TBI). (medscape.com)
  • The chest radiograph is usually normal in early disease. (cdc.gov)
  • Chest X-ray showed mediastinal lymphadenitis and consolidation on the right lung. (who.int)
  • It provides assessment of the potential etiology, extent, and distribution of disease and is more likely to detect underlying or coexisting disease (eg, occult mediastinal adenopathy, cancer, emphysema). (merckmanuals.com)
  • Pulmonary disease including pulmonary fibrosis, emphysema and pulmonary alveolar proteinosis has been observed in workers in the indium industry. (cdc.gov)
  • It is typically employed when there is a suspicion of certain diseases or conditions, such as lung cancer, lymphoma, infections, or inflammatory disorders, affecting the structures in this region. (schmetterermd.com)
  • Intracellular bacteria in Hodgkin s disease and sclerosing mediastinal B-cell lymphoma: sign of a bacterial etiology? (smw.ch)
  • Despite significant improvements in the treatment of Hodgkin's lymphoma over the past 2 decades, physicians continue to face dilemmas in therapy for the disease, and many cured patients live with complications of treatment. (cancernetwork.com)
  • This review considers the treatment of Hodgkin's lymphoma in younger patients, addressing such issues as which patients with early-stage disease may require radiotherapy, what prognostic factors provide information that can affect treatment choices in patients with advanced disease, and what we have learned about treatment complications in this setting. (cancernetwork.com)
  • Hodgkin's lymphoma (HL) is a rare, curable malignancy, and investigators have made remarkable improvements in treatment of the disease over the past 20 years. (cancernetwork.com)
  • Treatment protocols for classical Hodgkin lymphoma (HL) are provided below, including treatment for early-stage, advanced-stage, and relapsed/refractory disease. (medscape.com)
  • however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
  • Lymphoblastic lymphoma is aggressive and progresses rapidly, presenting as stage IV disease in more than 70% of patients (see Staging). (medscape.com)
  • These include differences in anatomy, physiology, pharmacokinetics, disease incidence and morbidity with certain infectious diseases. (ivis.org)
  • A 9-month-old girl was admitted to our department of paediatric infectious diseases in Samsun, Turkey with complaints of swelling on the right side of her neck and a draining lesion on her right forearm over the previous 2 months. (who.int)
  • Case 16-2022: A 55-Year-Old Man with Fevers, Night Sweats, and a Mediastinal Mass. N Engl J Med. (harvard.edu)
  • TAFRO Syndrome with an Anterior Mediastinal Mass and Lethal Autoantibody-Mediated Thrombocytopenia: An Autopsy Case Report. (harvard.edu)
  • In this report, a successful double lumen endobronchial intubation using "subcutaneous dissociative conscious sedation" as a novel method in the management of compromised airway (a case of a mediastinal mass) is presented. (scirp.org)
  • Clinical features: A 42 year- old, 62 Kg man was presented for an open biopsy of a middle mediastinal mass. (scirp.org)
  • S. Viswanathan, C. E. Campbell and R. C. Cork, "Asymptomatic Undetected Mediastinal Mass: A Death during Ambulatory Anesthesia," Journal of Clinical Anesthesiology, 1995, 7: 151-155. (scirp.org)
  • R. K. Sharma, L. Swain and N. Dave, "Anesthetic Management of a Patient with Malignant Mediastinal Mass," Indian Journal of Anaesthesia, Vol. 47, 2003, pp. 205207. (scirp.org)
  • P. Slinger and C. Karsli, "Management of the Patient with a Large Anterior Mediastinal Mass: Recurring Myths," Current Opinion in Anesthesiology, Vol. 20, No. 1, 2007, pp. 1-3. (scirp.org)
  • Clinical studies are part of clinical research and at the heart of all medical advances, including rare diseases. (nih.gov)
  • Clinical trials determine if a new test or treatment for a disease is effective and safe by comparing groups receiving different tests/treatments. (nih.gov)
  • People with a disease may participate to receive the newest possible treatment and additional care from clinical study staff as well as to help others living with the same or similar disease. (nih.gov)
  • For example, if clinical staging reveals stage IIIB or IV disease, surgery is not helpful and no pathological staging information will be obtained (appropriately). (wikipedia.org)
  • In this review, we consider the treatment of HL in younger patients, first evaluating recent clinical trials for early-stage disease, with a special focus on which patients may still need radiotherapy (RT). (cancernetwork.com)
  • Clinical imaging of MM and related diseases with PET/CT uses 18 F-labeled FDG, with other PET radiopharmaceuticals still investigational. (snmjournals.org)
  • The authors report a 4-year-old male with Hodgkin's disease with atypical clinical presentation, laboratory data and imaging studies as well as an increased radiosensitivity. (hindawi.com)
  • General reference Idiopathic interstitial pneumonias (IIPs) are interstitial lung diseases of unknown etiology that share similar clinical and radiologic features and are distinguished primarily by the histopathologic. (merckmanuals.com)
  • Suspected chronic beryllium disease (CBD) is a clinical indication for bronchoscopy. (cdc.gov)
  • Between February 2009 and July 2013, 402 patients with clinical stage I non-small cell lung cancer (NSCLC) underwent "non-grasping en bloc MLND" conducted by one surgical team. (medscape.com)
  • We perform detailed anatomic, functional, and physiologic imaging of the coronary arteries, myocardium, cardiac chambers, valves, aorta, pulmonary arteries, and pericardium using cardiac magnetic resonance imaging (MRI) and computed tomography (CT) in adults and pediatric patients suffering from a broad range of congenital and acquired cardiac diseases. (ohsu.edu)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION disease was confirmed in two patients, had two thoracenteses that produced se- view indicated mediastinal widening. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Our focus is on thorough evaluation and tailored surgical treatment in the areas of airway diagnostics, pleural disease, foregut oncology, GERD and swallowing, lung cancer, minimally invasive thoracic surgery, thoracic oncology, mediastinal diseases and hyperhidrosis. (swedish.org)
  • Our surgeons perform over 800 diagnostic procedures and 1,000 major surgeries each year encompassing a comprehensive range of airway, thoracic, esophageal and gastric diseases. (swedish.org)
  • D. Bitter, "Respiratory Obstruction Associated with Induction of General Anesthesia in a Patient with Mediastinal Hodgkin's Disease," Anesthesia & Analgesia, Vol. 54, No. 3, 1975, pp. 399-403. (scirp.org)
  • METHODS Fresh tissue samples (node or lung biopsy) taken from 23 patients with newly diagnosed sarcoidosis, 10 with other respiratory disease, and four patients with culture positive tuberculosis were analysed using PCR to amplify a 123 bp fragment of IS6110, the insertion element present in MTb, and nested PCR to further amplify an 85 bp sequence within the 123 bp product. (bmj.com)
  • RESULTS MTb DNA was not detected in any of the tissue samples from patients with sarcoidosis or other respiratory disease but was found in all four patients with tuberculosis. (bmj.com)
  • Ten patients with other respiratory disease undergoing lung biopsy or mediastinoscopy acted as negative controls, and four patients with tuberculosis and culture positive nodes acted as positive controls. (bmj.com)
  • However, there are a number of significant features peculiar to the donkey that practitioners should be aware of when attempting to investigate and treat respiratory disease. (ivis.org)
  • The WTC Cough Syndrome (a chronic cough syndrome, thought to be a consequence of upper and lower respiratory disease typically including chronic asthmatic bronchitis, chronic rhinosinusitis, chronic gastroesophageal reflux, or any combination of the three) has been reported by a large percentage of the exposed. (cdc.gov)
  • 33 Occurrences of WTC respiratory disease in rescue workers/volunteers whose first exposure was more than 48 hours post-collapse could be explained either by "high-level" exposures generated by activities that disturbed dust in place, while entering enclosed, poorly ventilated areas, or by the accumulation of repeated "low-level" exposures over time. (cdc.gov)
  • Histoplasmosis is one of the most common endemic mycosis in the United States and encompasses a spectrum of disease ranging from self-limited respiratory illness to disseminated infection (1-2). (cdc.gov)
  • Sudish Murthy, MD, PhD is the Section Head of Thoracic Surgery, the Daniel and Karen Lee Endowed Chair in Thoracic Surgery, Surgical Director of the Center of Major Airway Disease, and a Staff Thoracic Surgeon in the Department of Thoracic and Cardiovascular Surgery at The Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic. (clevelandclinic.org)
  • Recent studies have demonstrated that combination endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) and endoscopic ultrasound (EUS)-FNA is less invasive, offers near complete mediastinal staging (as well as the ability to diagnose M1 disease), and may afford superior diagnostic sensitivity in comparison with the standard surgical approach. (medpagetoday.com)
  • We offer a complete range of thoracic surgical procedures with an emphasis on thoracic oncology and benign diseases of the esophagus. (swedish.org)
  • A triathlete, and colon and rectal surgeon with Dignity Health Cancer Institute at St. Joseph's, Dr. Anathea Powell's medical expertise includes surgical treatment of all colon, rectal and anal conditions, including cancer, inflammatory bowel disease, hemorrhoids, and other anal problems. (dignityhealth.org)
  • Persons with a history of pulmonary disease can develop chronic pulmonary histoplasmosis. (cdc.gov)
  • 1 , 9 In persons who develop progressive, chronic, or disseminated disease, symptoms may persist for months or longer. (cdc.gov)
  • Non-grasping en bloc MLND enables en bloc dissection of mediastinal LNs with comparable morbidity and oncological efficacy while saving troubles of excessive interference of instruments and potential damage to the target LN. (medscape.com)
  • Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. (cdc.gov)
  • D. R. Northrip, B. K. Bohman and K. Tsueda, "Total Airway Occlusion and Superior Vena Cava Syndrome in a Child with Anterior Mediastinal Tumour," Anesthesia & Analgesia, Vol. 65, No. 10, 1986, pp. 1079-1082. (scirp.org)
  • This often poses diagnostic challenges because of the complexity of the mediastinal anatomic structures. (allenpress.com)
  • MM has 3 components: diffuse marrow infiltration, focal bone lesions, and soft-tissue (extramedullary) disease. (snmjournals.org)
  • Tissue biopsy of metastatic sites (including supraclavicular and mediastinal nodes and pleura) helps to assess disease extent. (family-health-information.com)
  • The aim of this study was to collect prospectively tissue from a carefully characterised cohort of patients with newly diagnosed sarcoidosis in whom tuberculous infection or prior disease had been excluded and to use PCR to search for DNA sequences specific for MTb. (bmj.com)
  • A mediastinal tumor resection removes abnormal tissue in this area. (epnet.com)
  • Fine-needle aspiration cytology plays a vital role in evaluation of mediastinal lesions. (allenpress.com)
  • Although the lungs are the initial site of infection, disease can spread to many organs. (msdmanuals.com)
  • If you are ill from any disease or notice medical symptoms, you should consult your doctor. (family-health-information.com)
  • Acute pulmonary histoplasmosis is the most common form of disease, and symptoms typically include fever, headache, malaise, and cough. (cdc.gov)
  • Distinct repeat infections have also been reported, typically involving acute pulmonary disease in endemic areas. (cdc.gov)
  • A Prospective Trial of Radiation Alone vs Combination Chemotherapy Alone for Early-Stage Hodgkin's Disease: Implications of 25-Year Follow-Up to Current Combined Modality Therapy. (yale.edu)
  • Longo D, Glatstein E, Duffey P, Young R, Fiem S, Jaffe E, Camphausen K, Wilson W, DeVita V . A Prospective Trial of Radiation Alone vs Combination Chemotherapy Alone for Early-Stage Hodgkin's Disease: Implications of 25-Year Follow-Up to Current Combined Modality Therapy. (yale.edu)
  • After partial resection of the tumor the histology indicated Hodgkin's disease-mixed cellularity. (hindawi.com)
  • C. Sandoval and M. Swift, "Hodgkin's disease in ataxia-telangiectasia patients with poor outcomes," Medical and Pediatric Oncology , vol. 40, no. 3, pp. 162-166, 2003. (hindawi.com)
  • R. Y. J. Tamminga, W. V. Dolsma, J. A. Leeuw, and H. H. Kampinga, "Chemo- and radiosensitivity testing in a patient with ataxia telangiectasia and Hodgkin's disease," Pediatric Hematology and Oncology , vol. 19, no. 3, pp. 163-171, 2002. (hindawi.com)
  • The concept of the GPOH-HD 2003 therapy study for pediatric Hodgkin's disease: evolution in the tradition of the DAL/GPOH studies," Klinische Pädiatrie , vol. 216, no. 3, pp. 150-156, 2004. (hindawi.com)
  • Immunodeficiency and Hodgkin's disease: treatment and outcome in the DAL HD78-90 and GPOH HD95 studies," Klinische Pädiatrie , vol. 215, no. 6, pp. 315-320, 2003. (hindawi.com)
  • Elevated Serum Small Dense Low-Density Lipoprotein Cholesterol May Increase the Risk and Severity of Coronary Heart Disease and Predict Cardiovascular Events in Patients with Type 2 Diabetes Mellitus. (nih.gov)
  • Ectopic Anterior Mediastinal Pancreas: An Unusual Case of New Onset Hemoptysis. (harvard.edu)
  • Hypercalcemia is a common paraneoplastic syndrome noted in the anterior mediastinal form. (dvm360.com)
  • For advanced disease, prognostic factors may provide information for those wishing to use treatment other than the ABVD regimen (Table 1) or other standard chemotherapy regimens. (cancernetwork.com)
  • Regimens that combine chemotherapy and radiation therapy (RT) have replaced RT alone for treatment of early-stage, favorable disease. (medscape.com)
  • In some cases where a patient with limited stage disease has only one small tumor, the tumor will be surgically removed, followed by chemotherapy. (family-health-information.com)
  • Fine-needle aspiration cytology (FNAC) was first introduced by Martin and Ellis 4 and has been used as an easy and safe procedure for diagnosing primary and metastatic mediastinal diseases. (allenpress.com)
  • The unusual finding of extensive mediastinal disease raised the possibility that the patient had inhalational melioidosis. (cdc.gov)
  • Tuberculosis (TB) properly refers only to disease caused by Mycobacterium tuberculosis (for which humans are the main reservoir). (msdmanuals.com)
  • It is a disease caused by strains of Mycobacterium tuberculosis that are resistant to at least isoniazid and rifampicin, the 2 most powerful first-line anti-tuberculosis drugs (1-3). (who.int)
  • Severe pulmonary disease can involve a wide range of complications (3). (cdc.gov)
  • The young patient with HL treated in the past had a greater chance of dying of some malignancy other than HL, and at an earlier age than someone who has not had the disease. (cancernetwork.com)
  • Relapse therapy can cure approximately 50% of patients, depending on patient- and disease-related features, and failure of initial therapy, once considered an ominous sign, may not be such a poor feature any longer. (cancernetwork.com)
  • Newer therapy options are needed for the disease-not only novel initial therapy designed to treat the patient with minimal complications, but also therapy for those in relapse. (cancernetwork.com)
  • Further laboratory evaluation for a patient with a positive initial workup for CBD is performed to determine disease progression. (cdc.gov)
  • Newer therapeutic options are still needed for the disease, to minimize complications and to improve the treatment of patients in relapse. (cancernetwork.com)
  • Still, physicians face dilemmas in therapy for the disease, and many cured patients live with complications of treatment. (cancernetwork.com)
  • Recent trials suggest that ABVD or variants of this combination with or without RT may still be the best therapy for early-stage HL, regardless of the type of disease presentation, and the potential for complications of therapy may ultimately direct choices of treatment. (cancernetwork.com)