A common, benign, usually self-limited viral infection of the skin and occasionally the conjunctivae by a poxvirus (MOLLUSCUM CONTAGIOSUM VIRUS). (Dorland, 27th ed)
A species of MOLLUSCIPOXVIRUS causing skin lesions in humans. It is transmitted by direct contact or from non-living reservoirs (fomites), such as books or clothing.
A CC-type chemokine with specificity for CCR10 RECEPTORS. It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION.
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.
A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects.
Benign epidermal proliferations or tumors; some are viral in origin.
Inorganic compounds that contain potassium as an integral part of the molecule.
Virus diseases caused by the POXVIRIDAE.
A scraping, usually of the interior of a cavity or tract, for removal of new growth or other abnormal tissue, or to obtain material for tissue diagnosis. It is performed with a curet (curette), a spoon-shaped instrument designed for that purpose. (From Stedman, 25th ed & Dorland, 27th ed)

Interferon alpha treatment of molluscum contagiosum in immunodeficiency. (1/55)

A sister (aged 6 years) and brother (aged 8 years) presented four months apart with severe molluscum contagiosum. Both children demonstrated clinical and laboratory evidence of combined immunodeficiency. The extent of skin involvement by molluscum contagiosum precluded conventional treatment as well as intralesional interferon alpha (IFN alpha). Both subjects responded well to subcutaneous IFN alpha.  (+info)

Molluscum contagiosum and warts. (2/55)

Molluscum contagiosum and warts are benign epidermal eruptions resulting from viral infections of the skin. Molluscum contagiosum eruptions are usually self-limited and without sequelae, although they can be more extensive in immunocompromised persons. Spontaneous disappearance of lesions is the norm, but treatment by local destruction (curettage, cryotherapy, or trichloroacetic acid) or immunologic modulation can shorten the disease course, possibly reducing autoinoculation and transmission. Warts result from a hyperkeratotic reaction to human papillomavirus infection; nongenital warts are classified as common, periungual, flat, filiform, or plantar, based on location and shape. Warts are treated by local destruction (acids, cryotherapy, electrodesiccation-curettage), chemotherapy, or immunotherapy. The choice of treatment varies with the age and wishes of the patient, the potential side effects of the treatment, and the location of the lesions.  (+info)

Clinical profile of molluscum contagiosum in children versus adults. (3/55)

Molluscum contagiosum mainly affects children, but in adults the advent of HIV has modified its clinical spectrum. Our study is designed to ascertain the clinical profile of molluscum contagiosum in children and adults and to discover the effects of underlying HIV infection. During the study period of September 2000 to June 2002, 150 cases of molluscum contagiosum are screened and recruited at the Department of Dermatology and STD, JIPMER, Pondicherry. These include 137 children (85 male, 52 female) and 13 adults (10 male, 3 female). In children molluscum contagiosum is most commonly seen in the 5-10-year age group (58 cases), followed by the 1-5-year age group (53 cases), the 10-14-year age group (23 cases), and the younger-than-1-year age group (3 cases). In adults molluscum contagiosum is most commonly seen in the 14-20-year age group, followed by 2 cases each in the age groups 20-26 years, 26-34 years, and 34-40 years. The male-to-female sex ratio was 1.6:1 in children and 3.3:1 in adults. In both children and adults the most common sites affected are the head and neck, followed by trunk, upper extremity, genitalia, and lower extremity. It appears that the distribution of molluscum in our patients is significantly affected by the high proportion of HIV-positive adults in our sample. Seropositivity for HIV by ELISA is found in 1 of 137 children and 8 of 13 adults. In these HIV-positive patients, 2 cases of giant molluscum and one furuncle-like presentation are seen.  (+info)

The incidence of molluscum contagiosum, scabies and lichen planus. (4/55)

We aimed to describe the incidence of new episodes of molluscum contagiosum, scabies and lichen planus presenting to general practitioners in England and Wales. We examined data collected in a sentinel practice network (the Weekly Returns Service of the Royal College of General Practitioners) in which about half a million persons were observed each year over the period 1994-2003. The incidence of molluscum contagiosum in males was 243/100,000 person-years and in females 231; of scabies, males 351, females 437; of lichen planus, males 32, females 37. Incidence varied by year and age. Ninety per cent of molluscum contagiosum episodes were reported in children aged 0-14 years, where incidence in 2000 (midpoint of a 6-year period of stable incidence) was 1265/100,000 (95% CI 1240-1290). Scabies affected all ages and annual incidence ranged between 233 (95% CI 220-246) in 2003 and 470 (95% CI 452-488) in 2000. Lichen planus occurred chiefly in persons aged over 45 years: incidence (all ages) ranged between 27 (95% CI 23-31) in 2003 and 43 (95% CI 37-49) in 1998. The relative risk of female to male incidence (all ages) of molluscum contagiosum was 0.95 (95% CI 0.91-0.99); of scabies 1.25 (95% CI 1.21-1.28); and of lichen planus 1.19 (95% CI 1.08-1.13).  (+info)

Specimens from a vesicular lesion caused by molluscum contagiosum virus produced a cytopathic effect in cell culture that mimicked that produced by herpes simplex virus. (5/55)

Infection with molluscum contagiosum virus, a poxvirus, normally has a typical clinical presentation; therefore, laboratory confirmation is infrequently sought and the virus is rarely isolated in culture. As reported herein, viral culture of specimens from atypical lesions may produce an abortive infection in limited cell lines and a cytopathic effect suggestive of herpes simplex virus.  (+info)

Interferon-alpha treatment of molluscum contagiosum in a patient with hyperimmunoglobulin E syndrome. (6/55)

We report widely disseminated molluscum contagiosum that occurred in a 9-year-old boy secondary to hyperimmunoglobulin E syndrome, a primary immunodeficiency disorder. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes. They were distributed throughout the perineal and gluteal areas and bilaterally over his lower limbs. A biopsy specimen from his skin lesion demonstrated lobulated epidermal growth that consisted of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Many treatments for his skin lesions were ineffective, including physical destruction or manual extrusion of the lesions; cryotherapy; curettage; and topical therapies with phenol, trichloroacetic acid, and imiquimod. The patient was treated successfully with subcutaneous interferon-alpha for 6 months without any adverse effect.  (+info)

TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. (7/55)

Langerhans cells (LC) are a unique subset of dendritic cells (DC), present in the epidermis and serving as the first line of defense against pathogens invading the skin. To investigate the role of human LCs in innate immune responses, we examined TLR expression and function of LC-like DCs derived from CD34+ progenitor cells and compared them to DCs derived from peripheral blood monocytes (monocyte-derived DC; Mo-DC). LC-like DCs and Mo-DCs expressed TLR1-10 mRNAs at comparable levels. Although many of the TLR-induced cytokine patterns were similar between the two cell types, stimulation with the TLR3 agonist poly(I:C) triggered significantly higher amounts of the IFN-inducible chemokines CXCL9 (monokine induced by IFN-gamma) and CXCL11 (IFN-gamma-inducible T cell alpha chemoattractant) in LC-like DCs as compared with Mo-DCs. Supernatants from TLR3-activated LC-like DCs reduced intracellular replication of vesicular stomatitis virus in a type I IFN-dependent manner. Finally, CXCL9 colocalized with LCs in skin biopsy specimens from viral infections. Together, our data suggest that LCs exhibit a direct antiviral activity that is dependent on type I IFN as part of the innate immune system.  (+info)

T-cell memory: the importance of chemokine-mediated cell attraction. (8/55)

A recent study demonstrates the involvement of certain chemokines in immune response initiation and CD8+ T-cell memory formation. These seminal findings broaden our understanding of the role of chemokines in adaptive immune processes.  (+info)

Molluscum contagiosum is a viral skin infection that results in small, round, painless, and pearly or flesh-colored bumps on the skin. These bumps have a dimple in the center and can appear anywhere on the body but are most commonly found in warm, moist areas such as the armpits, behind the knees, and in the groin area. The virus that causes molluscum contagiosum is called the Molluscum contagiosum virus (MCV) and is part of the poxvirus family.

The infection spreads through direct contact with an infected person or through contact with contaminated objects such as towels, clothing, or toys. It can also be transmitted through sexual contact, making it a common sexually transmitted infection (STI) in adults. The incubation period for molluscum contagiosum ranges from two weeks to six months, and the bumps typically appear 2-7 weeks after exposure.

Molluscum contagiosum is generally a self-limiting condition that resolves on its own within 6-12 months without scarring. However, treatment may be recommended for cosmetic reasons or to prevent the spread of infection. Treatment options include cryotherapy (freezing the bumps with liquid nitrogen), curettage (scrapping off the bumps), topical medications, and laser therapy.

Preventive measures such as good hygiene practices, avoiding sharing personal items, covering lesions, and practicing safe sex can help prevent the spread of molluscum contagiosum.

Molluscum contagiosum (MCV) is a DNA poxvirus that causes a common, benign, and generally self-limited skin infection known as molluscum contagiosum. This viral infection results in small, raised, pearly or flesh-colored bumps or papules on the skin. The lesions typically have a dimple or pit in the center and can appear anywhere on the body, but they are most commonly found in warm, moist areas such as the armpits, behind the knees, and in the groin area.

MCV is highly contagious and can spread through direct skin-to-skin contact, including sexual contact, or through contact with contaminated objects like towels or clothing. It is more common in children than adults, but in sexually active individuals, it often presents as a genital infection. The incubation period for MCV ranges from two weeks to several months, and the infection usually resolves on its own within 6-12 months, although treatment may be considered to expedite clearance or reduce transmission risk.

Chemokine CCL27, also known as CTACK (Cutaneous T-cell attracting chemokine) or Exodus-3, is a small signaling protein that belongs to the CC chemokine family. Chemokines are a group of cytokines, or cell signaling molecules, that play an important role in immune function and inflammation by recruiting immune cells to sites of infection or tissue injury.

Chemokine CCL27 is primarily produced by keratinocytes, the major cell type in the epidermis, and it plays a crucial role in skin immunity by attracting specific subsets of T cells to the skin. It binds to and activates the CCR10 receptor on the surface of these T cells, leading to their migration towards the site of chemokine production.

In addition to its role in skin immunity, Chemokine CCL27 has also been implicated in several diseases, including psoriasis, atopic dermatitis, and certain types of cancer.

"Pharmaceutical solutions" is a term that refers to medications or drugs that are formulated in a liquid state, as opposed to solid forms like tablets or capsules. These solutions are typically created by dissolving the active pharmaceutical ingredient (API) in a solvent, such as water or ethanol, along with other excipients that help stabilize and preserve the solution.

Pharmaceutical solutions can be administered to patients through various routes, including oral, intravenous, subcutaneous, or intramuscular injection, depending on the desired site of action and the specific properties of the drug. Some examples of pharmaceutical solutions include antibiotic infusions, pain medications, and electrolyte replacement drinks.

It's important to note that the term "pharmaceutical solutions" can also refer more broadly to the process of developing and manufacturing drugs, as well as to the industry as a whole. However, in a medical context, it most commonly refers to liquid medications.

Poxviridae is a family of large, complex, double-stranded DNA viruses that includes many significant pathogens affecting humans and animals. The most well-known member of this family is the Variola virus, which causes smallpox in humans, a highly contagious and deadly disease that has been eradicated through global vaccination efforts. Other important human pathogens in this family include the Monkeypox virus, which can cause a smallpox-like illness, and the Molluscum contagiosum virus, which causes benign skin tumors.

Poxviruses have a unique ability to replicate in the cytoplasm of host cells, rather than in the nucleus like many other DNA viruses. They also have a complex structure, with a large, brick-shaped virion that contains a lateral body, a core, and an outer envelope. The genome of poxviruses is relatively large, ranging from 130 to 375 kilobases in length, and encodes many genes involved in viral replication, host immune evasion, and modulation of host cell processes.

Poxviridae is further divided into two subfamilies: Chordopoxvirinae, which includes viruses that infect vertebrates, and Entomopoxvirinae, which includes viruses that infect insects. The Chordopoxvirinae subfamily is divided into several genera, including Orthopoxvirus (which includes Variola, Monkeypox, and Vaccinia viruses), Parapoxvirus (which includes Orf virus and Bovine papular stomatitis virus), and Yatapoxvirus (which includes Yaba monkey tumor virus and Tanapox virus).

Overall, Poxviridae is a diverse family of viruses that pose significant public health and agricultural threats, and continue to be the subject of ongoing research and development efforts aimed at understanding their biology and developing new vaccines and therapies.

Warts are small, rough growths on the skin or mucous membranes caused by one of several types of human papillomavirus (HPV). They can appear anywhere on the body but most often occur on the hands, fingers, and feet. Warts are benign, non-cancerous growths, but they can be unsightly, uncomfortable, or painful, depending on their location and size.

Warts are caused by HPV infecting the top layer of skin, usually through a small cut or scratch. The virus triggers an overproduction of keratin, a protein in the skin, leading to the formation of a hard, rough growth. Warts can vary in appearance depending on their location and type, but they are generally round or irregularly shaped, with a rough surface that may be flat or slightly raised. They may also contain small black dots, which are actually tiny blood vessels that have clotted.

Warts are contagious and can spread from person to person through direct skin-to-skin contact or by sharing personal items such as towels or razors. They can also be spread by touching a wart and then touching another part of the body. Warts may take several months to develop after exposure to HPV, so it may not always be clear when or how they were contracted.

There are several types of warts, including common warts, plantar warts (which occur on the soles of the feet), flat warts (which are smaller and smoother than other types of warts), and genital warts (which are sexually transmitted). While most warts are harmless and will eventually go away on their own, some may require medical treatment if they are causing discomfort or are unsightly. Treatment options for warts include topical medications, cryotherapy (freezing the wart with liquid nitrogen), and surgical removal.

Potassium compounds refer to substances that contain the element potassium (chemical symbol: K) combined with one or more other elements. Potassium is an alkali metal that has the atomic number 19 and is highly reactive, so it is never found in its free form in nature. Instead, it is always found combined with other elements in the form of potassium compounds.

Potassium compounds can be ionic or covalent, depending on the properties of the other element(s) with which it is combined. In general, potassium forms ionic compounds with nonmetals and covalent compounds with other metals. Ionic potassium compounds are formed when potassium donates one electron to a nonmetal, forming a positively charged potassium ion (K+) and a negatively charged nonmetal ion.

Potassium compounds have many important uses in medicine, industry, and agriculture. For example, potassium chloride is used as a salt substitute and to treat or prevent low potassium levels in the blood. Potassium citrate is used to treat kidney stones and to alkalinize urine. Potassium iodide is used to treat thyroid disorders and to protect the thyroid gland from radioactive iodine during medical imaging procedures.

It's important to note that some potassium compounds can be toxic or even fatal if ingested in large quantities, so they should only be used under the supervision of a healthcare professional.

Poxviridae infections refer to diseases caused by the Poxviridae family of viruses, which are large, complex viruses with a double-stranded DNA genome. This family includes several pathogens that can infect humans, such as Variola virus (which causes smallpox), Vaccinia virus (used in the smallpox vaccine and can rarely cause infection), Monkeypox virus, and Cowpox virus.

These viruses typically cause skin lesions or pocks, hence the name "Poxviridae." The severity of the disease can vary depending on the specific virus and the immune status of the host. Smallpox, once a major global health threat, was declared eradicated by the World Health Organization in 1980 thanks to a successful vaccination campaign. However, other Poxviridae infections continue to pose public health concerns, particularly in regions with lower vaccination rates and where animal reservoirs exist.

Curettage is a medical procedure that involves scraping or removing tissue from the lining of an organ or body cavity, typically performed using a curette, which is a long, thin surgical instrument with a looped or sharp end. In gynecology, curettage is often used to remove tissue from the uterus during a procedure called dilation and curettage (D&C) to diagnose or treat abnormal uterine bleeding, or to remove residual placental or fetal tissue following a miscarriage or abortion. Curettage may also be used in other medical specialties to remove damaged or diseased tissue from areas such as the nose, throat, or skin.

No FAQ available that match "molluscum contagiosum"

No images available that match "molluscum contagiosum"