A chronic progressive subcutaneous infection caused by species of fungi (eumycetoma), or actinomycetes (actinomycetoma). It is characterized by tumefaction, abscesses, and tumor-like granules representing microcolonies of pathogens, such as MADURELLA fungi and bacteria ACTINOMYCETES, with different grain colors.
A mitosporic fungal genus that causes MYCETOMA in humans. Madurella grisea and M. mycetomatis are the etiological agents.
Infections with bacteria of the genus NOCARDIA.
Skin diseases of the foot, general or unspecified.
A species of bacterium of the family NOCARDIACEAE, producing pulmonary infections in man.
Infections with bacteria of the order ACTINOMYCETALES.
A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.
Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.
A country in northeastern Africa. The capital is Khartoum.

Immune response to Nocardia brasiliensis antigens in an experimental model of actinomycetoma in BALB/c mice. (1/156)

Nine- to twelve-week-old BALB/c mice were injected in footpads with 10(7) CFU of a Nocardia brasiliensis cell suspension. Typical actinomycetoma lesions, characterized by severe local inflammation with abscess and fistula formation, were fully established by day 28 after infection. These changes presented for 90 days, and then tissue repair with scar formation slowly appeared, with complete healing after 150 days of infection. Some animals developed bone destruction in the affected area. Histopathology showed an intense inflammatory response, with polymorphonuclear cells and hyaloid material around the colonies of the bacteria, some of which were discharged from draining abscesses. Sera from experimental animals were analyzed by Western blotting, and immunodominant antigens P61 and P24 were found as major targets for antibody response. Anti-P24 immunoglobulin M (IgM) isotype antibodies were present as early as 7 days, IgG peaking 45 days after infection. Lymphocyte proliferation with spleen and popliteal lymph node cells demonstrated thymidine incorporation at 7 days after infection, the stimulation index decreasing by day 60. Levels of interleukin-1 (IL-1), IL-2, IL-4, IL-6, tumor necrosis factor alpha, and gamma interferon (IFN-gamma) were determined by enzyme-linked immunosorbent assay in the sera of infected animals. The circulating levels of IFN-gamma increased more than 10 times the basal levels; levels of IL-4, IL-6 and IL-10 also increased during the first 4 days of infection.  (+info)

Peritonitis by scedosporium apiospermum in a patient undergoing continuous ambulatory peritoneal dialysis. (2/156)

A case of peritonitis due to Scedosporium apiospermum in a boy undergoing continuous ambulatory peritoneal dialysis is reported. The finding of suggestive tissual form of the fungus in the effluent hastened the diagnosis of the infection.  (+info)

Cutaneous Scedosporium apiospermum infection in an immunocompromised patient. (3/156)

Scedosporium apiospermum infection occurred in the left forearm of a patient who was taking oral prednisolone for pulmonary fibrosis. The infection appeared to follow a scratch from a blackcurrant bush. This is the first reported case in the United Kingdom of a cutaneous infection from Scedosporium apiospermum in an immunocompromised patient.  (+info)

Mycetoma in an HIV-infected patient. (4/156)

Although opportunistic fungal infections occur commonly in immunocompromised hosts, mycetoma has never been reported in association with HIV infection. The authors present a case that to their knowledge is the first reported case of mycetoma associated with HIV infection. Diagnosis was confirmed by direct examination of grains and histologic examination. Precise identification of the agent, an actinomycete, was not possible. The unusual site of infection may probably be related to the use of contaminated needless and syringes for HIV drug injection.  (+info)

Meningitis caused by Pseudallescheria boydii treated with voriconazole. (5/156)

Meningitis caused by Pseudallescheria boydii is an uncommon infection of the CNS that usually has a poor prognosis and a difficult treatment. We describe a case of chronic meningitis caused by P. boydii in an immunocompetent host that was successfully treated with voriconazole, a new antifungal agent.  (+info)

Medical management of mycetoma. (6/156)

A number of drugs and drug combinations were tested both in vitro and in vivo against pathogens causing actinomycetoma and maduromycetoma. Of 144 patients with actinomycetoma treated, 63.2% were cured, 21.5% showed great improvement in their condition, and 11.1% showed some improvement. Treatment was successful even when there was advanced bone involvement. The most effective treatments involved dapsone plus streptomycin sulfate or sulfamethoxazole-trimethoprim plus streptomycin. Sulfadoxine-pyrimethamine plus streptomycin or rifampicin plus streptomycin also gave good results. Griseofulvin plus penicillin showed some promise in the management of maduromycetoma caused by Madurella mycetomi but at the present time this should be used only as an adjunct to surgery. All mycetoma patients undergoing drug therapy should be carefully monitored and treatment should be temporarily suspended if anaemia or leucopenia develop.  (+info)

Molecular variability of Pseudallescheria boydii, a neurotropic opportunist. (7/156)

The sequences of the internal transcribed spacer (ITS) ribosomal DNA (rDNA) domain data obtained by restriction fragment length polymorphism analysis with 18S rDNA and fingerprinting (M13) for clinical and environmental strains of Pseudallescheria boydii (anamorph, Scedosporium apiospermum) were compared to those for related species of Pseudallescheria, Petriella, and Scedosporium. The infraspecific variability of P. boydii was considerable. There were five different lengths in the 18S rDNAs within P. boydii due to the occurrence of introns. In several cases, strains isolated from a single pond or ditch proved to be genetically very different. Nevertheless, some lineages had a regional distribution. The variability found is unlikely to be explained by meiotic recombination alone. Pseudallescheria fusoidea, Pseudallescheria ellipsoidea, and Pseudallescheria angusta were found to be synonyms for P. boydii. Scedosporium prolificans was found amid Petriella species in the ITS tree and showed no infraspecific variability. The type strain of Rhinocladium lesnei proved to be identical to Graphium putredinis. Acladium castellanii, which is morphologically reminiscent of S. apiospermum, was also found to be a separate species, but with an unknown affiliation.  (+info)

White grain mycetoma caused by a Cylindrocarpon sp. in India. (8/156)

We describe a case of white grain eumycetoma of the foot of an Indian male caused by a slow-growing, poorly sporulating fungus that does not match any known agent of this infection. Histologic examination of a biopsy tissue specimen showed oval, lobular, white granules composed of hyaline, septate hyphae, and thick-walled chlamydospores. Culture of granules from a draining sinus yielded compact, very-slow-growing, poorly sporulating colonies producing a strong reddish brown pigment that diffused into the medium. The fungus was identified as a Cylindrocarpon sp. based on the development of rare cylindrical conidia borne from solitary phialides lacking collarettes, in addition to chlamydospores formed singly or in short chains.  (+info)

Mycetoma is a chronic granulomatous infection of the skin and subcutaneous tissues, often characterized by tumefaction, sinus formation, and grains. It's typically caused by certain species of fungi (eumycetoma) or bacteria (actinomycetoma). The infection usually enters the body through traumatic inoculation of the organism into the skin or underlying tissue, often in the foot or hand. The disease is most commonly found in tropical and subtropical regions, particularly in Africa, Latin America, and Asia.

"Madurella" is not a medical term itself, but it is the name of a genus of fungi that can cause certain types of infections in humans. This genus is part of the family "Bipolarisaceae" and order "Chaetothyriales." The most common species that affects humans is "Madurella mycetomatis," which is known to cause a chronic subcutaneous infection called mycetoma. Mycetoma is a slowly progressive, granulomatous disease characterized by the formation of multiple sinuses and grains in the affected tissues. It primarily affects the feet but can also involve other parts of the body. The fungus enters the body through traumatic implantation, usually from contaminated soil or thorn pricks.

In summary, "Madurella" is a genus of fungi that includes species capable of causing mycetoma, a chronic subcutaneous infection in humans.

Nocardia infections are caused by Nocardia species, a type of gram-positive, aerobic, filamentous bacteria that can be found in soil, dust, and decaying vegetation. These infections primarily affect the lungs (pulmonary nocardiosis) when the bacteria are inhaled but can also spread to other parts of the body, causing disseminated nocardiosis. People with weakened immune systems, such as those with HIV/AIDS, organ transplants, or long-term steroid use, are at a higher risk of developing Nocardia infections. Symptoms vary depending on the site of infection and may include cough, chest pain, shortness of breath, skin abscesses, brain abscesses, or joint inflammation. Diagnosis typically involves microbiological culture and identification of the bacteria from clinical samples, while treatment usually consists of long-term antibiotic therapy, often involving multiple drugs.

Foot dermatoses refer to various skin conditions that affect the feet. These can include inflammatory conditions like eczema and psoriasis, infectious diseases such as athlete's foot (tinea pedis), fungal infections, bacterial infections, viral infections (like plantar warts caused by HPV), and autoimmune blistering disorders. Additionally, contact dermatitis from irritants or allergens can also affect the feet. Proper diagnosis is essential to determine the best course of treatment for each specific condition.

"Nocardia asteroides" is a species of aerobic, gram-positive bacteria that can be found in soil and water. It is a type of actinomycete that can cause various infectious diseases in humans and animals, known as nocardiosis. The bacterium has the ability to form branching filaments, which can resemble fungal hyphae, and it often forms hard, rough colonies on culture media. Nocardia asteroides is known for its resistance to various antibiotics and can cause a range of clinical manifestations, including pulmonary, cutaneous, and disseminated infections. It is typically treated with drugs such as sulfonamides, trimethoprim-sulfamethoxazole, or imipenem.

Actinomycetales are a group of gram-positive bacteria that can cause various types of infections in humans. The term "Actinomycetales infections" is used to describe a range of diseases caused by these organisms, which are characterized by the formation of characteristic granules or "actinomycetes" composed of bacterial cells and inflammatory tissue.

Some common examples of Actinomycetales infections include:

1. Actinomycosis: A chronic infection that typically affects the face, neck, and mouth, but can also occur in other parts of the body such as the lungs or abdomen. It is caused by various species of Actinomyces, which are normal inhabitants of the mouth and gastrointestinal tract.
2. Nocardiosis: A rare but serious infection that can affect the lungs, brain, or skin. It is caused by the bacterium Nocardia, which is found in soil and water.
3. Mycetoma: A chronic infection that affects the skin and underlying tissues, causing the formation of nodules and sinuses that discharge pus containing grains composed of fungal or bacterial elements. It is caused by various species of Actinomyces, Nocardia, and other related bacteria.
4. Streptomyces infections: While Streptomyces species are best known for their role in producing antibiotics, they can also cause infections in humans, particularly in immunocompromised individuals. These infections can affect various organs, including the lungs, skin, and soft tissues.

Treatment of Actinomycetales infections typically involves the use of antibiotics, often for prolonged periods of time. The specific antibiotic regimen will depend on the type of infection and the susceptibility of the causative organism to various antimicrobial agents. Surgical intervention may also be necessary in some cases to drain abscesses or remove infected tissue.

Mitosporic fungi, also known as asexual fungi or anamorphic fungi, are a group of fungi that produce mitospores (also called conidia) during their asexual reproduction. Mitospores are produced from the tip of specialized hyphae called conidiophores and are used for dispersal and survival of the fungi in various environments. These fungi do not have a sexual reproductive stage or it has not been observed, making their taxonomic classification challenging. They are commonly found in soil, decaying organic matter, and water, and some of them can cause diseases in humans, animals, and plants. Examples of mitosporic fungi include Aspergillus, Penicillium, and Fusarium species.

Acquired foot deformities refer to structural abnormalities of the foot that develop after birth, as opposed to congenital foot deformities which are present at birth. These deformities can result from various factors such as trauma, injury, infection, neurological conditions, or complications from a medical condition like diabetes or arthritis.

Examples of acquired foot deformities include:

1. Hammertoe - A deformity where the toe bends downward at the middle joint, resembling a hammer.
2. Claw toe - A more severe form of hammertoe where the toe also curls under, forming a claw-like shape.
3. Mallet toe - A condition where the end joint of a toe is bent downward, causing it to resemble a mallet.
4. Bunions - A bony bump that forms on the inside of the foot at the big toe joint, often causing pain and difficulty wearing shoes.
5. Tailor's bunion (bunionette) - A similar condition to a bunion, but it occurs on the outside of the foot near the little toe joint.
6. Charcot foot - A severe deformity that can occur in people with diabetes or other neurological conditions, characterized by the collapse and dislocation of joints in the foot.
7. Cavus foot - A condition where the arch of the foot is excessively high, causing instability and increasing the risk of ankle injuries.
8. Flatfoot (pes planus) - A deformity where the arch of the foot collapses, leading to pain and difficulty walking.
9. Pronation deformities - Abnormal rotation or tilting of the foot, often causing instability and increasing the risk of injury.

Treatment for acquired foot deformities varies depending on the severity and underlying cause but may include orthotics, physical therapy, medication, or surgery.

I'm sorry for any confusion, but "Sudan" is not a medical term. It is a country located in Northeast Africa, known as the Sudan or Sudan proper, and the southern region that seceded to become South Sudan in 2011. If you have any medical terms you would like me to define, please let me know!

"Orphanet: Mycetoma". www.orpha.net. Retrieved 2018-04-17. Verma, P.; Jha, A. (March 2019). "Mycetoma: reviewing a neglected ... There are currently no rapid diagnostic tools for mycetoma. Mycetoma is diagnosed through microscopic examination of the grains ... People who develop mycetoma likely have a weakened immune system. It can take between 3 months to 50 years from time of ... Mycetoma is caused by common saprotrophs found in the soil and on thorny shrubs in semi-desert climates. Some common causative ...
... "mycetoma belt." Fungal mycetoma (eumycetoma) is the most common type in Africa, while bacterial mycetoma (actinomycetoma) ... Mycetoma does not spread between people. Diagnosis. A doctor can diagnose mycetoma by taking a small sample (biopsy) of the ... If mycetoma is not treated or if treatment fails, it can spread to other areas of the body. Long-term mycetoma can eventually ... Mycetoma affects people of all ages and is more common in men. Many people with mycetoma work in agricultural jobs, such as ...
Mycetoma is a chronic subcutaneous infection caused by actinomycetes or fungi. This infection results in a granulomatous ... Mycetoma infection can be caused by fungi or bacteria. When caused by fungi, it is referred to as mycotic mycetoma or ... Mycetoma has no apparent racial predilection. Mycetoma is more common in men than in women, with male-to-female ratios ranging ... Mycetoma causes disfigurement but is rarely fatal in the absence of skull involvement. Although mycetoma carries a low risk of ...
... photos and unpublished archives about Mycetoma, many of them with free online access. ... On mycetoma, or, The fungus disease of India / by H. Vandyke Carter.. , Date: 1874 ... Mycetoma / El Sheikh Mahgoub, Ian G. Murray.. Mahgoub, El Sheikh. , Date: [1973] ...
Worlds first clinical trial for devastating fungal disease mycetoma shows efficacy of new, promising treatment. ...
"Madurella mycetoma: a neglected tropical disease", Clinical Microbiology and Infection, 2021 ... along with irregular eosinophilic grains surrounding a mass of fungal hyphae and yeast forms suggestive of eumycotic mycetoma ...
Mycetoma is classified as actinomycetoma (bacterial mycetoma) or eumycetoma (fungal mycetoma) based on its causative agent. ... What is mycetoma?. Mycetoma is a chronic, granulomatous, progressively destructive infectious disease of the subcutaneous ... The Sixth International Conference on Mycetoma was preceded by the First International Training Workshop on Mycetoma from 10 to ... The way mycetoma is transmitted has not been fully elucidated. Treatment is long and costly and outcomes are often ...
... ✅ Paper Type: Free Essay. ✅ Subject: Medical. ... "Dot in Circle" sign - a unique attribute of mycetoma foot on MRI: a report of two cases Aggarwal A, Gupta M, Patel B N, Patel S ... This is a unique appearance and is easily recognisable in mycetoma. [1] This sign was proposed by Sarris et al. in 2003 on T2- ... Mycetoma revisited. Incidence of various radiographic signs. Abd El-Bagi ME, Fahal AH Saudi Med J. 2009 Apr; 30(4):529-33. ...
2020 JCAD , The Journal of Clinical and Aesthetic Dermatology. All rights reserved ...
A combination of trimethoprim/sulfamethoxazole with linezolid is useful for actinomycotic mycetoma: A summary of the existing ... In actinomycotic mycetoma, when the correct species is not identified, it makes logical sense to combine two classes of drugs. ... A combination of trimethoprim/sulfamethoxazole with linezolid is useful for actinomycotic mycetoma: A summary of the existing ... A novel treatment option for the treatment of a non-responsive case of actinomycotic mycetoma. Indian J Dermatol Venereol ...
... mycetoma is prevalent. The difference is very important for therapy. All causative agents of fungal mycetoma are exosaprophytes ... Mycetoma of shoulder and back. Pathogens. Mycetomas are caused by 2 totally different groups of organisms: the first are moulds ... Mycetoma. Mycetomas are chronic, inflammatory swellings with numerous sinuses, caused by moulds or bacteria. The causative ... In 75% of cases, a mycetoma is localised on the foot (Madura foot). In addition to involvement of soft tissue; bone tissue is ...
Mycetoma under the microscope with GMS ...
Neglected Tropical Disease Mycetoma Research Gains Momentum. Patients outside the Mycetoma Research Center in Sudan. Credit: ...
Mycetoma is a devastating, chronic infectious disease of the skin and subcutaneous tissue that can be either bacterial in ... Mycetoma is a devastating, chronic infectious disease of the skin and subcutaneous tissue that can be either bacterial in ... The incidence and prevalence of the disease has not been well known (mycetoma is not a notifiable disease and there are no ... Our ISNTD Disease Brief on mycetoma introduces the disease, and gives an overview of both current treatments as well as those ...
The aim of this article is to describe briefly about mycetoma infection and its Homoeopathic management ... Mycetoma infection and homoeopathic management. Mycetoma infection and homoeopathic management. February 13, 2023 admin ... KEYWORDS- Skin, Mycetoma, Homoeopathy. INTRODUCTION. MYCETOMA- Is a chronic subcutaneous infection caused by actinomycetes or ... Mycetoma can affect all age groups, but it occurs more commonly in young men aged between 20 and 40 years, with male to female ...
Mycetoma Research Center, Sudan, University of Khartoum ,Soba University Hospital ... Mycetoma is a serious global health issue affecting mostly young adults in developing countries, particularly those of low ... The First Clinical Trial in Mycetoma. Drugs for Neglected Diseases initiative and Eisai Co., Ltd. to Test Drug Candidate for ... There are major knowledge gaps about mycetoma in general, including about its transmission, prevalence, route of infection, and ...
Mycetoma - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional ... Mycetoma occurs in equatorial regions of Africa, Latin America, and Asia known as the "mycetoma belt." Fungal mycetoma (also ... Mycetoma Research Center (World Health Organization Collaborating Center on Mycetoma): Mycetoma management guidelines ... Symptoms and Signs of Mycetoma The initial lesion of mycetoma may be a papule, a fixed subcutaneous nodule, a vesicle with an ...
The outlook for mycetoma is not wholly grim, however. In fact, there are several glimmers of hope in the pipeline of mycetoma ... has launched the first clinical trial of a drug to treat mycetoma. The study is occurring at the Mycetoma Research Center in ... Mycetoma and Neglected Tropical Diseases A Medical, Scientific, and Moral Duty to Care Article Sidebar. ... Dias, M. (2016). Mycetoma and Neglected Tropical Diseases: A Medical, Scientific, and Moral Duty to Care. Voices in Bioethics, ...
Neglected Tropical Disease Mycetoma Research Gains Momentum By Geoffrey Kamadi. The disease burden and distribution of mycetoma ...
Neglected Tropical Disease Mycetoma Research Gains Momentum By Geoffrey Kamadi. The disease burden and distribution of mycetoma ...
Mycetoma-presentation of a case is an article from MOJ Biology and Medicine for MedCrave Group. The clinical case of a 45-year- ... Mycetoma-presentation of a case. MOJ Biology and Medicine Annia Moraga Rodríguez,,sup,1,/sup, Alina Moraga Rodríguez,,sup,1,/ ...
... in Tambaram, Chennai - View Doctors, Book an Appointment Online / Find Address - Jithya ...
Nearly 20,000 cases and patients with mycetoma are now described in the literature going back to 1876. In a new paper from ... Overall, mycetoma has been described in 102 countries, with the largest number from Mexico, India and Sudan. The relative ... Nearly 20,000 cases and patients with mycetoma are now described in the literature going back to 1876. In a new paper from ...
Key immune system molecules are detected in mycetoma, a chronic, destructive inflammatory disease. ... Mycetoma of the foot. Mycetoma Research Center, University of Khartoum Two molecules that accumulate in the microenvironment of ... Monitoring immune molecules in mycetoma. Published online 15 July 2019 Key immune system molecules are detected in mycetoma, a ... Siddig, E. E. et al. Interleukin-17 and matrix metalloprotease-9 expression in the mycetoma granuloma. PLOS Negl. Trop. Dis. 13 ...
Eumycotic mycetoma Caused by pigmented/black fungi due to melanin -Numerous species found in soil -2% of cases of mycetoma - ... Actinomycotic Mycetoma There are two types of Mycetoma: 1. Actinomycotic - caused by higher bacteria species 2. Eumycotic - ... Mycetoma • First observed in India and known as Madura Foot or Maduromycosis • Found in the hot temperate parts of the world • ... Subcutaneous Fungal Infections Most common will be described • Mycetoma [2 types] • Actinomycotic - caused by higher bacteria ...
... mycetoma; research and development; access to medicines; and integrated health services…" (5/28). ...
Mycetoma Information documents EB137/INF./1. Statement by the representative of the WHO staff associations ...
mycetoma, fungal infection, usually localized in the foot but occurring occasionally elsewhere on the body, apparently ... mycetoma, fungal infection, usually localized in the foot but occurring occasionally elsewhere on the body, apparently ...
Early diagnosis, treatment and epidemiology of mycetoma. Mycetoma in the Sudan: an update from the Mycetoma Research Centre, ... What is mycetoma?. The World health Organization describes mycetoma as, "… a chronic, progressively destructive morbid ... According to the DNDi, mycetoma is endemic in tropical and subtropical areas within the Mycetoma belt-this endemic area is ... mycetoma reached the discussion floor. At the risk of sounding naïve, Im going to tell you that I had never heard of mycetoma ...

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