Neoplasms, Fibroepithelial
Polyps
Phyllodes Tumor
Ureteral Neoplasms
Fibroadenoma
Tonsillar lymphangiomatous polyps: a clinicopathologic series of 26 cases. (1/15)
BACKGROUND: Lymphangiomatous polyps are uncommon benign tumors of the tonsils. METHODS: Twenty-six cases of lymphangiomatous polyps diagnosed between 1980 and 1999 were retrieved from the files of the Otorhinolaryngic-Head and Neck Tumor Registry of the Armed Forces Institute of Pathology. Hematoxylin and eosin-stained slides were reviewed to characterize the histologic features of these tumors. Immunohistochemical stains were performed on 15 cases. Clinical follow-up data were obtained. RESULTS: The patients included 13 males and 13 females, ages 3 to 63 years (mean, 25.2 years). Patients experienced dysphagia, sore throat, and the sensation of a mass in the throat. Symptoms were present from a few weeks to years. The tonsillar masses were unilateral in all cases. Clinically, the lesions were frequently mistaken for a neoplasm (n = 18 patients). Grossly, all of the lesions were polypoid and measured 0.5 to 3.8 cm (mean, 1.6 cm). Histologically, the polyps were covered by squamous epithelium showing variable epithelial hyperplasia, dyskeratosis, and lymphocytic epitheliotropism. The masses showed a characteristic submucosal proliferation of small to medium-sized, endothelial-lined, lymph-vascular channels lacking features of malignancy. Collagen, smooth muscle, and adipose tissue were present in the stroma. Intravascular proteinaceous fluid and lymphocytes were noted. Immunohistochemical findings confirmed the endothelial origin of the vascular proliferation and a mixed lymphoid population. The differential diagnosis included fibroepithelial polyp, lymphangioma, juvenile angiofibroma, and squamous papilloma. In all patients with follow-up, complete surgical excision was curative (mean follow-up, 5.4 years; range, 1 mo to 14 years). CONCLUSIONS: We detail the clinical and pathologic features of tonsillar lymphangiomatous polyps. These tumors are uncommon and may clinically be mistaken for a malignant neoplasm. The characteristic histologic features should allow for its correct diagnosis and differentiation from similar appearing tonsillar lesions. (+info)Aggressive giant fibroepithelial lesion with unusual vascular stroma--a case report. (2/15)
The stroma of fibroadenoma and phyllodes tumor usually consists of fibroblastic proliferation. Rarely the stroma contains bundles of smooth muscle. Pseudoangiomatous hyperplasia of the mammary stroma has been described in fibroadenomas. However, true benign vascular stroma has not been reported. We report a case of a 34-year-old Chinese woman who presented with a large mass occupying the entire left breast. Left mastectomy was performed and showed a large, well-circumscribed, lobulated, rubbery-firm tumor measuring 13 x 10 x 6 cm. Microscopic examination revealed a fibroepithelial tumor formed by an organoid pattern of ductal structures with a very striking stromal appearance composed of extensive vascular proliferation and that demonstrated strong immunoreactivity for CD31, CD34, and Factor VIII. Ultrastructural examination revealed intercellular junctions, basal lamina, pinocytotic vesicles, and Weibel-Palade bodies in the cells lining the vascular spaces, confirming their endothelial nature. These findings rule out the diagnosis of pseudoangiomatous hyperplasia. The patient developed local recurrence a year later, and the resection showed malignant phyllodes tumor with ductal carcinoma in situ. The extensive vascular stroma noted in the primary tumor may have played a role in the malignant transformation of the epithelial and stromal components in this tumor. (+info)Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast. (3/15)
INTRODUCTION: Hypoxia-inducible factor 1 (HIF-1) alpha and its downstream targets carbonic anhydrase IX (CAIX) and vascular endothelial growth factor (VEGF) are key factors in the survival of proliferating tumor cells in a hypoxic microenvironment. We studied the expression and prognostic relevance of HIF-1alpha and its downstream targets in phyllodes tumors and fibroadenomas of the breast. METHODS: The expression of HIF-1alpha, CAIX, VEGF and p53 was investigated by immunohistochemistry in a group of 37 primary phyllodes tumors and 30 fibroadenomas with known clinical follow-up. The tumor microvasculature was visualized by immunohistochemistry for CD31. Proliferation was assessed by Ki67 immunostaining and mitotic counts. Being biphasic tumors, immunoquantification was performed in the stroma and epithelium. RESULTS: Only two fibroadenomas displayed low-level stromal HIF-1alpha reactivity in the absence of CAIX expression. Stromal HIF-1alpha expression was positively correlated with phyllodes tumor grade (P = 0.001), with proliferation as measured by Ki67 expression (P < 0.001) and number of mitoses (P < 0.001), with p53 accumulation (P = 0.003), and with global (P = 0.015) and hot-spot (P = 0.031) microvessel counts, but not with CAIX expression. Interestingly, concerted CAIX and HIF-1alpha expression was frequently found in morphologically normal epithelium of phyllodes tumors. The distance from the epithelium to the nearest microvessels was higher in phyllodes tumors as compared with in fibroadenomas. Microvessel counts as such did not differ between fibroadenomas and phyllodes tumors, however. High expression of VEGF was regularly found in both tumors, with only a positive relation between stromal VEGF and grade in phyllodes tumors (P = 0.016). Stromal HIF-1alpha overexpression in phyllodes tumors was predictive of disease-free survival (P = 0.032). CONCLUSION: These results indicate that HIF-1alpha expression is associated with diminished disease-free survival and may play an important role in stromal progression of breast phyllodes tumors. In view of the absence of stromal CAIX expression in phyllodes tumors, stromal upregulation of HIF-1alpha most probably arises from hypoxia-independent pathways, with p53 inactivation as one possible cause. In contrast, coexpression of HIF-1alpha and CAIX in the epithelium in phyllodes tumors points to epithelial hypoxia, most probably caused by relatively distant blood vessels. On the other hand, HIF-1alpha and CAIX seem to be of minor relevance in breast fibroadenomas. (+info)Ureteral fibroepithelial polyp in an owl monkey (Aotus nancymae). (4/15)
Ureteral fibroepithelial polyps are benign mesodermal tumors in humans that occur predominantly in the proximal ureter. During a routine necropsy of a wild-caught, research naive, adult, male, Aotus nancymae, the left ureter just distal to the renal pelvis contained a pedunculated, lobulated neoplasm with a narrow stalk at the base projecting into the lumen. The left renal pelvis was found to be mildly dilated. The histologic characteristics of the ureteral mass were consistent with a fibroepithelial polyp. To our knowledge, this is the first report describing a ureteral fibroepithelial polyp in a nonhuman primate. (+info)Fibroepithelial hamartoma in a domestic pig. (5/15)
This case report is the first description of a fibroepithelial hamartoma in a pig. The dysplasia, which covered half of the face of the newborn piglet, did not increase in relative size until the animal was euthanatized at 6 months of age. Histologic examination revealed a moderate orthokeratotic hyperkeratosis with variable degrees of epithelial proliferation. The main body of the dysplasia consisted of collagenous fibers. In addition, some proliferating small blood vessels as well as focally gathered dilated apocrine glands were evident. Given morphologic and clinical features, the diagnosis of a hamartoma seemed to be justified. (+info)Fibroepithelioma of Pinkus with pleomorphic epithelial giant cells. (6/15)
Fibroepithelioma of Pinkus is a rare, indolent variant of basal cell carcinoma (BCC). The presence of pleomorphic giant cells in such a tumor is extremely rare and to our knowledge, only one such case has been previously reported in the literature. We report another case occurring as a pedunculated, gluteal lesion in an 82-year-old man. The nodule was lightly pigmented, polypoid, and measured 1.0 cm in greatest dimension. Immunohistochemical staining confirmed that the giant cells were of epithelial origin and that the proliferative rate of these cells was low. (+info)Lymphedematous fibroepithelial polyps of the penis associated with long-term condom catheter use: case report and review of the literature. (7/15)
(+info)Obstructive ileus due to a giant fibroepithelial polyp of the anus. (8/15)
Fibroepithelial polyps or hypertrophied anal papillae are essentially skin tags that project up from the dentate line and the junction between the skin and the epithelial lining of the anus. They are usually small in size, but sometimes they become enlarged, causing unexpected medical conditions. An extremely rare case of a giant hypertrophied anal papilla complicated by obstructive ileus is reported. Fibroepithelial anal polyp, despite its size, should be included in the differential diagnosis of a smooth mass located near the anal verge, especially in a patient with a history of chronic anal irritation or infection. (+info)Fibroepithelial neoplasms are benign (non-cancerous) growths that consist of both fibrous and epithelial tissue. These types of neoplasms can occur in various parts of the body, but they are most commonly found in the skin and mucous membranes. A well-known example of a fibroepithelial neoplasm is a skin tag (acrochordon). Other examples include fibroma, papilloma, and neurofibroma.
Fibroepithelial neoplasms are typically slow-growing and cause little to no discomfort or symptoms. However, they may be removed for cosmetic reasons or if they become irritated, inflamed, or start to bleed. In rare cases, a fibroepithelial neoplasm can undergo malignant transformation and develop into cancer. It is essential to have any new or changing growths evaluated by a healthcare professional to determine the appropriate course of action.
A polyp is a general term for a small growth that protrudes from a mucous membrane, such as the lining of the nose or the digestive tract. Polyps can vary in size and shape, but they are usually cherry-sized or smaller and have a stalk or a broad base. They are often benign (noncancerous), but some types of polyps, especially those in the colon, can become cancerous over time.
In the digestive tract, polyps can form in the colon, rectum, stomach, or small intestine. Colorectal polyps are the most common type and are usually found during routine colonoscopies. There are several types of colorectal polyps, including:
* Adenomatous polyps (adenomas): These polyps can become cancerous over time and are the most likely to turn into cancer.
* Hyperplastic polyps: These polyps are usually small and benign, but some types may have a higher risk of becoming cancerous.
* Inflammatory polyps: These polyps are caused by chronic inflammation in the digestive tract, such as from inflammatory bowel disease (IBD).
Polyps can also form in other parts of the body, including the nose, sinuses, ears, and uterus. In most cases, polyps are benign and do not cause any symptoms. However, if they become large enough, they may cause problems such as bleeding, obstruction, or discomfort. Treatment typically involves removing the polyp through a surgical procedure.
A Phyllodes tumor is a rare type of breast tumor that originates from the connective tissue (stroma) that supports the breast lobules and ducts. These tumors can be benign, borderline, or malignant, depending on their level of invasiveness and cellular atypia.
Phyllodes tumors are typically large, firm, and well-circumscribed masses with a leaf-like (phyllode) internal architecture. They can grow quickly and may cause symptoms such as pain, swelling, or a palpable lump in the breast. Surgical excision is the primary treatment for Phyllodes tumors, and the extent of surgery depends on the tumor's size, grade, and margins. Regular follow-up is necessary to monitor for recurrence.
Ureteral neoplasms refer to abnormal growths or tumors in the ureters, which are the tubes that carry urine from the kidneys to the bladder. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Benign ureteral neoplasms are rare and usually do not pose a significant health risk, although they may need to be removed if they cause obstructions or other complications.
Malignant ureteral neoplasms, on the other hand, are more serious and can spread to other parts of the body. The most common type of malignant ureteral neoplasm is transitional cell carcinoma (TCC), which arises from the cells that line the inside of the ureters. Other types of malignant ureteral neoplasms include squamous cell carcinoma, adenocarcinoma, and sarcoma.
Symptoms of ureteral neoplasms may include hematuria (blood in the urine), flank pain, weight loss, and fatigue. Diagnosis typically involves imaging tests such as CT scans or MRIs, as well as urine cytology and biopsy to confirm the presence of cancer cells. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
A fibroadenoma is a benign (noncancerous) breast tumor that is most commonly found in women between the ages of 15 and 35, although it can occur at any age. It is composed of glandular and connective tissue. The tumor typically feels firm, smooth, and rubbery, and its size may vary from quite small to over 2 inches in diameter.
Fibroadenomas are usually mobile within the breast tissue, which means they can be moved around easily when touched. They can occur as a single lump or multiple lumps (known as fibroadenomatosis). The exact cause of fibroadenomas is not known, but hormonal factors may play a role in their development.
Fibroadenomas are generally not painful, although some women may experience discomfort or tenderness, especially before their menstrual period. In most cases, fibroadenomas do not require treatment and can be monitored with regular breast exams and imaging studies such as mammography or ultrasound. However, if a fibroadenoma grows larger or becomes uncomfortable, it may be removed through a surgical procedure.
Vaginal neoplasms refer to abnormal growths or tumors in the vagina. These growths can be benign (non-cancerous) or malignant (cancerous). The two main types of vaginal neoplasms are:
1. Vaginal intraepithelial neoplasia (VAIN): This is a condition where the cells on the inner lining of the vagina become abnormal but have not invaded deeper tissues. VAIN can be low-grade or high-grade, depending on the severity of the cell changes.
2. Vaginal cancer: This is a malignant tumor that arises from the cells in the vagina. The two main types of vaginal cancer are squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma is the most common type, accounting for about 85% of all cases.
Risk factors for vaginal neoplasms include human papillomavirus (HPV) infection, smoking, older age, history of cervical cancer or precancerous changes, and exposure to diethylstilbestrol (DES) in utero. Treatment options depend on the type, stage, and location of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
Bronchial neoplasms refer to abnormal growths or tumors in the bronchi, which are the large airways that lead into the lungs. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Malignant bronchial neoplasms are often referred to as lung cancer and can be further classified into small cell lung cancer and non-small cell lung cancer, depending on the type of cells involved.
Benign bronchial neoplasms are less common than malignant ones and may include growths such as papillomas, hamartomas, or chondromas. While benign neoplasms are not cancerous, they can still cause symptoms and complications if they grow large enough to obstruct the airways or if they become infected.
Treatment for bronchial neoplasms depends on several factors, including the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.
Fibroepithelial neoplasm
Fibrous tissue neoplasm
Oral mucosa
Phyllodes tumor
List of MeSH codes (C04)
Oral medicine
List of vaginal tumors
Breast disease
List of skin conditions
Fibroadenoma
Vulvar tumors
Skin tag
International Classification of Diseases for Oncology
Fibroepithelial neoplasm - Wikipedia
Premalignant Fibroepithelial Tumor (Pinkus Tumor): Background, Pathophysiology, Etiology
Research | Discipline of Laboratory Medicine | Memorial University of Newfoundland
出版物 - Saba Yasir, M.B.B.S. - 妙佑医疗国际
Rosen's Diagnosis of Breast Pathology by Needle Core Biopsy PDF Free Download
Bio2Vec
Pesquisa | Biblioteca Virtual em Saúde - BRASIL
Cancers of the Nervous System | Oncology Classifications
Oral pathology - Libre Pathology
BVS Paraguay
Imaging of the oesophagus: beyond cancer | Insights into Imaging | Full Text
Article|International Journal of Current Research and Review
Bio2Vec
Sunidhi Chauhan - Texter till Aaja nachle + översättning till
View source for Breast biopsy or excision - patholines.org
Connective tissue neoplasm
Malignant neoplasm of skin (Concept Id: C0007114) - MedGen - NCBI
SurgPath4U Case Viewer
Merkel Cell Carcinoma and Rare Appendageal Tumors: Overview, Tumors of the Epidermis, Tumorlike Lesions of Fibrous or Elastic...
Importance Cerebral white matter (WM) damage has been reported in child - The Role of Mitochondria in Apoptosis
Registro Tumori Veneto - Statistiche
Contemporary Issues in Breast Pathology | USCAP eLearning
Acne Vulgaris | Hope Merz | Dermatology in Cincinnati
Oncology Articles (Diagnosis, Staging, Treatment, Prognosis, Follow-up) - Medscape Reference
Fibropapilomatosis en tortugas marinas:: una visión de conjunto | Revista de Investigaciones Marinas
Neoplasm staging. Medical search. Definitions
Breast Cancer
Indian Journal of Dermatology: Table of Contents
SciELO - Brazil - Mammary fibroadenomatoid hyperplasia in a heifer Mammary fibroadenomatoid hyperplasia in a heifer
American Journal of Case Reports | Giant Fibroepithelial Polyps of the Vulva in a Woman with Uterine Myoma and Primary...
Lesions5
- Ongoing - Erivwo P , Salama S, Gai L. Mrkonjic M. Armstrong S. Turashvili G. Point-Based Weighted Diagnostic Scale for Histopathologic Assessment of Mammary Cellular Fibroepithelial Lesions. (mun.ca)
- The most common types of skin lesions include Nevi (raised and flat moles), Seborrheic Keratoses, Cherry Angiomas, Fibroepithelial Polyps (skin tags), Sebaceous Hyperplasias, and Milia. (351face.com)
- Phyllodes tumours are rare fibroepithelial lesions. (hindawi.com)
- Neoplasms of nonepithelial origin, although uncommon, are lesions that a busy gastrointestinal (GI) endoscopist can expect to encounter with some regularity. (clinicalgate.com)
- Ductal Carcinoma In Situ: Risk Factor or Cancer -- Diagnostic Management of Papillomas, Radial Scars, and Flat Epithelial Atypia: Core Biopsy Alone Versus Core Biopsy Plus Excision -- Diagnostic Management of Fibroepithelial Lesions: When Is Excision Indicated? (nshealth.ca)
Rare fibroepithelial2
- These neoplasms are a group of rare fibroepithelial tumors of the breast, accounting for 0.3-1.0% of breast tumors. (bvsalud.org)
- Phyllodes tumors are a group of rare fibroepithelial tumors of the breast, accounting for 0.3-1.0% of all breast tumors (5, 6). (bvsalud.org)
Polyps2
- Fibroepithelial stromal polyps are polypoid with a circumscribed border. (surgpath4u.com)
- Fibroepithelial Polyps are more commonly known as skin tags. (351face.com)
Benign4
- Phyllodes tumor which derives from the greek word "phullon" or leaf are group of biphasic fibroepithelial tumors of breast of varying malignant potential ranging from benign tumor to fully malignant sarcomas. (ijcrr.com)
- These other benign entities include fibroepithelial stromal polyp, angiomyofibroblastoma and cellular angiofibroma. (surgpath4u.com)
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
- The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
Tumors of the breast1
- Phyllodes tumors of the breast are unusual fibroepithelial tumors that exhibit a wide range of clinical behavior. (jnccn.org)
Polyp1
- Laparoscopic dismembered pyeloplasty revealed a left ureteropelvic junction obstruction secondary to a large fibroepithelial polyp in the proximal ureter with a concomitant anterior crossing vein. (mcmaster.ca)
Squamous cell1
- Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. (nih.gov)
Basal1
- Constitutive activation of this pathway in human keratinocytes has been shown to produce a neoplasm identical to basal cell carcinoma. (medscape.com)
Premalignant Fibroepithelial Tumor1
- The fibroepithelioma of Pinkus is an unusual neoplasm that was first described by Hermann Pinkus in 1953 as a premalignant fibroepithelial tumor. (medscape.com)
Tumor4
- A fibroepithelial neoplasm (or tumor) is a biphasic tumor. (wikipedia.org)
- La edad promedio fue de 45.9 años, el diagnóstico se realizó por biopsia con aguja gruesa, donde el informe anatomopatológico reveló tumor filoides en el 72% de los casos, la excéresis tumoral fue el tratamiento, sin complicaciones. (bvsalud.org)
- connective tissue tumor is a neoplasm arising from the tissues of the connective tissue . (ipfs.io)
- The term phyllodes tumor represents a broad range of fibroepithelial diseases and presence of an epithelial component with stromal components differentiates the phyllodes tumor from other stromal sarcomas. (hindawi.com)
Metastatic3
- A primary or metastatic malignant neoplasm involving the skin. (nih.gov)
- Metastatic malignant neoplasms to the skin include carcinomas and lymphomas. (nih.gov)
- Metastatic nodules of the umbilicus from malignant neoplasms are known as Sister Mary Joseph's nodule and they represent an advanced malignancy. (irispublishers.com)
Primary1
- Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Tumours2
- EN":"Top five tumours most diagnosed in Veneto and proportion with the total number of tumours by sex"},"freq_title_inc_asl":{"IT":"Primi cinque tumori pi\u00f9 frequentemente diagnosticati nella ASLX e proporzione sul totale dei tumori per sesso. (registrotumoriveneto.it)
- EN":"Exclusions: DCO, lost to follow-up, incompatible morfology or topografy according to 2016 AIRTUM monography 'La sopravvivenza dei pazienti oncologici in Italia', multiple tumours cases on the same site. (registrotumoriveneto.it)
Breast1
- They were first fully characterized by Johannes Muller in 1838 1 and constitute 0.3% to 1% of all breast neoplasm. (ijcrr.com)
Tissue4
- Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
- Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
- The concept does not refer to neoplasms located in tissue composed of squamous elements. (nih.gov)
- Neoplasms composed of tissue of the mesothelium, the layer of flat cells, derived from the mesoderm, which lines the body cavity of the embryo. (bvsalud.org)
Spindle2
- Aggressive (deep) angiomyxoma is a paucicellular neoplasm consisting of spindle-shaped cells with delicate cytoplasmic processes embedded in a loose myxoid stroma. (surgpath4u.com)
- Superficial angiomyxoma is also a mxyoid neoplasm with bland spindle cells. (surgpath4u.com)
Acanthoma1
- In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)
Disease1
- EN":"Only municipalities with at least 25000 residents have been included in the comparison"},"consulta_monografie":{"IT":"Consulta le monografie","EN":"View ULSS reports"},"dato_non_disponibile":{"IT":"Dato non disponibile","EN":"Not available data"},"disease_comparison":{"IT":"Confronto per sede tumorale. (registrotumoriveneto.it)
20192
- Anni 2017-2019","EN":"Tumour site comparison. (registrotumoriveneto.it)
- Anni 2017-2019","EN":"Rate per 100,000 population. (registrotumoriveneto.it)
Stromal1
- HMGA2 positivity is also aberrantly expressed in occasional vulvovaginal smooth muscle neoplasms -- it has emerged as a helpful stain in distinguishing aggressive angiomyxomas from other stromal neoplasms and in some cases, assessing resection margins (Oliva, McCluggage 2009). (surgpath4u.com)
Organs2
- The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
- The concept does not refer to neoplasms located in these organs. (bvsalud.org)
Skin1
- The advantage to your specimen being read by a dermatopathologist is that they specialize in skin and skin-related neoplasms only, qualifying them to be absolute experts in this area. (351face.com)
Terms1
- Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
Cases2
- n. 196 , 30 June 2003 and further modifications"},"button_esporta_tabella":{"IT":"Esporta tabella","EN":"Export table"},"casi":{"IT":"casi","EN":"cases"},"casi_per_anno_label":{"IT":"casi per anno","EN":"new cases per year"},"comuni_descr":{"IT":"Sono stati inclusi nel confronto i comuni con pi\u00f9 di 25000 abitanti. (registrotumoriveneto.it)
- Infrequent cases of mammary neoplasms have been reported in cattle ( POVEY & OSBORNE, 1969 POVEY, R.C. (scielo.br)