Neoplastic Processes
Precancerous Conditions
Cell Transformation, Neoplastic
Neoplasms
Gene Expression Regulation, Neoplastic
Peutz-Jeghers Syndrome
Dental Amalgam
Pigmentation Disorders
Death Certificates
p53 mutations in tumor and non-tumor tissues of thorotrast recipients: a model for cellular selection during radiation carcinogenesis in the liver. (1/52)
Concerns over cancer development from exposure to environmental sources of densely ionizing, high linear energy transfer (LET) radiation, such as alpha-particles from radon, is a current public health issue. The study of tumors attributable to high LET irradiation would greatly augment our insights into the biological mechanisms of carcinogenesis. Chronic low-dose-rate internal exposure to alpha-radiation from thorium dioxide deposits following intravascular administration of the radiographic contrast agent Thorotrast is known to markedly increase the risk of cancer development, especially that of hepatic angiosarcomas and cholangiocarcinomas. Although the mechanism is hypothesized to be via cellular damage, DNA being a major target, wrought by the high LET alpha-particles, the specific genes and the actual sequence of events involved in the process of transforming a normal cell into a malignant one are largely unknown. To shed some light on the molecular mechanisms of cancer development during a lifetime exposure to alpha-radiation, we analyzed the most commonly affected tumor suppressor gene in humans, p53, in 20 Thorotrast recipients who developed cancer, mostly of hepatic bile duct and blood vessel origin. Of the 20 cases, 19 were found to harbor p53 point mutations. Moreover, the accompanying non-tumor tissues from these patients also had p53 mutations, albeit at lower frequency. The distribution pattern of the point mutations was significantly different between the non-tumor and tumor tissues, with most mutations in malignant tissues located in the highly conserved domains of the p53 gene. Our results support the idea that p53 mutations are important in the genesis of Thorotrast-induced tumors but that these point mutations are a secondary outcome of genomic instability induced by the irradiation. Additionally, non-tumor cells harboring p53 mutations may gain some survival advantage in situ but mutations in the domains responsible for the formation of structural elements critical in binding DNA may be necessary for a cell to reach full malignancy. (+info)A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. (2/52)
High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled clinical trial. A total of 48 women with biopsy-proven breast cancer (T(1-2), N(0-2), M0) were randomised to the control group in which modified radical mastectomy was performed, and the HIFU group in which an extracorporeal HIFU ablation of breast cancer was followed by modified radical mastectomy. Short-term follow-up, pathologic and immunohistochemical stains were performed to assess the therapeutic effects on tumour and complications of HIFU. The results showed that no severe side effect was observed in the HIFU-treated patients. Pathologic findings revealed that HIFU-treated tumour cells underwent complete coagulative necrosis, and tumour vascular vessels were severely damaged. Immunohistochemical staining showed that no expression of PCNA, MMP-9, and CD44v6 was detected within the treated tumour cells in the HIFU group, indicating that the treated tumour cells lost the abilities of proliferation, invasion, and metastasis. It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the extracorporeal treatment of localised breast cancer. (+info)Natural history of multifocal solitary fibrous tumors of the pleura: a 25-year follow-up report. (3/52)
We report this case with "multifocal solitary fibrous tumors of the pleura," which recurred at different sites in the left pleura at different time intervals over a span of 25 years, finally exhibiting features of malignant transformation. This patient was first seen in 1978, when she was 58 years of age, for episodic attacks of hypoglycemia and a mass occupying the entire left hemithorax. The operative findings and histologic appearance were that of a solitary fibrous tumor. (+info)Respiration under control of uncoupling proteins: Clinical perspective. (4/52)
The term 'uncoupling protein' was originally used for the mitochondrial membrane protein UCP1, which is uniquely present in mitochondria of brown adipocytes, thermogenic cells that regulate body temperature in small rodents, hibernators and mammalian newborns. In these cells, UCP1 acts as a proton carrier activated by free fatty acids and creates a shunt between complexes of the respiratory chain and ATP-synthase resulting in a futile proton cycling and dissipation of oxidation energy as heat. Recent identification of new homologues to UCP1 expressed in brown and white adipose tissue, muscle, brain and other tissues together with the hypothesis that these novel uncoupling proteins (UCPs) may regulate thermogenesis and/or fatty acid metabolism and furthermore may protect against free radical oxygen species production have generated considerable optimism for rapid advances in the identification of new targets for pharmacological management of complex pathological syndromes such as obesity, type 2 diabetes or chronic inflammatory diseases. However, since the physiological and biochemical roles of the novel UCPs are not yet clear, the main challenge today consists first of all in providing mechanistic explanation for their functions in cellular physiology. This lively awaited information may be the basis for potential pharmacological targeting of the UCPs in future. (+info)Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis. (5/52)
Thy-1 (CD90) is a 25-37 kDa glycosylphosphatidylinositol (GPI) -anchored glycoprotein expressed on many cell types, including T cells, thymocytes, neurons, endothelial cells, and fibroblasts. Activation of Thy-1 can promote T cell activation, and this role of Thy-1 is reviewed elsewhere. Thy-1 also affects numerous nonimmunologic biological processes, including cellular adhesion, neurite outgrowth, tumor growth, migration, and cell death. In reviewing the nonimmunologic functions of Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the role of the GPI anchor in Thy-1 localization to lipid rafts and signaling, and regulation of Thy-1 expression. Thy-1 is an important regulator of cell-cell and cell-matrix interactions, with important roles in nerve regeneration, metastasis, inflammation, and fibrosis. (+info)Heavy smoking and liver. (6/52)
Smoking causes a variety of adverse effects on organs that have no direct contact with the smoke itself such as the liver. It induces three major adverse effects on the liver: direct or indirect toxic effects, immunological effects and oncogenic effects. Smoking yields chemical substances with cytotoxic potential which increase necro-inflammation and fibrosis. In addition, smoking increases the production of pro-inflammatory cytokines (IL-1, IL-6 and TNF- alpha) that would be involved in liver cell injury. It contributes to the development of secondary polycythemia and in turn to increased red cell mass and turnover which might be a contributing factor to secondary iron overload disease promoting oxidative stress of hepatocytes. Increased red cell mass and turnover are associated with increased purine catabolism which promotes excessive production of uric acid. Smoking affects both cell-mediated and humoral immune responses by blocking lymphocyte proliferation and inducing apoptosis of lymphocytes. Smoking also increases serum and hepatic iron which induce oxidative stress and lipid peroxidation that lead to activation of stellate cells and development of fibrosis. Smoking yields chemicals with oncogenic potential that increase the risk of hepatocellular carcinoma (HCC) in patients with viral hepatitis and are independent of viral infection as well. Tobacco smoking has been associated with suppression of p53 (tumour suppressor gene). In addition, smoking causes suppression of T-cell responses and is associated with decreased surveillance for tumour cells. Moreover, it has been reported that heavy smoking affects the sustained virological response to interferon (IFN) therapy in hepatitis C patients which can be improved by repeated phlebotomy. Smoker's syndrome is a clinico-pathological condition where patients complain of episodes of facial flushing, warmth of the palms and soles of feet, throbbing headache, fullness in the head, dizziness, lethargy, prickling sensation, pruritus and arthralgia. (+info)The cancer stem cell hypothesis: a work in progress. (7/52)
There is a growing body of evidence that supports the idea that malignant tumors are initiated and maintained by a population of tumor cells that share similar biologic properties to normal adult stem cells. This model, the cancer stem cell (CSC) hypothesis, is based on the observation that tumors, like adult tissues, arise from cells that exhibit the ability to self-renew as well as give rise to differentiated tissue cells. Although the concept of the CSC is not entirely new, advances made over the past two decades in our understanding of normal stem cell biology in conjunction with the recent application of these concepts to experimentally define CSCs have resulted in the identification of CSCs in several human malignancies. (+info)Do we need to redefine a cancer metastasis and staging definitions? (8/52)
Metastasis is the most lethal attribute of cancer cells and clinical decisions regarding treatment are based largely upon the likelihood of developing metastases. However, improvements in detection as well as recent experimental data have raised questions about the most appropriate definition of a metastasis, especially whether the mere presence of cells at secondary sites constitute a metastatic lesion. After reviewing the experimental basis of metastasis, a definition of metastasis is proffered along with a proposal to consider regarding modification of staging parameters. (+info)Neoplastic processes refer to the abnormal and uncontrolled growth and division of cells, leading to the formation of tumors or malignancies, which can be benign or cancerous, and may invade local tissues or spread to distant sites via metastasis.
Neoplastic processes refer to the abnormal and uncontrolled growth and division of cells, leading to the formation of tumors or neoplasms. These processes can be benign or malignant, depending on the characteristics of the cells and the degree of invasion and spread to surrounding tissues.
Benign neoplasms are localized and do not invade nearby tissues or spread to other parts of the body. They are usually slow-growing and may cause symptoms due to their size or location, but they are rarely life-threatening.
Malignant neoplasms, on the other hand, are cancerous and have the ability to invade surrounding tissues and spread to distant sites through a process called metastasis. They are characterized by uncontrolled cell growth, genetic mutations, and abnormal cell division, leading to the formation of malignant tumors that can be life-threatening if not treated promptly and effectively.
Neoplastic processes can occur in any part of the body and can have various causes, including genetic factors, exposure to environmental carcinogens, viral infections, and chronic inflammation. Early detection and treatment of neoplastic processes are crucial for improving outcomes and preventing complications.
'Precancerous conditions', also known as dysplasia, refer to abnormal cell changes that have a higher-than-normal chance of developing into cancer, although not all precancerous conditions will necessarily become malignant.
A precancerous condition, also known as a premalignant condition, is a state of abnormal cellular growth and development that has a higher-than-normal potential to progress into cancer. These conditions are characterized by the presence of certain anomalies in the cells, such as dysplasia (abnormal changes in cell shape or size), which can indicate an increased risk for malignant transformation.
It is important to note that not all precancerous conditions will eventually develop into cancer, and some may even regress on their own. However, individuals with precancerous conditions are often at a higher risk of developing cancer compared to the general population. Regular monitoring and appropriate medical interventions, if necessary, can help manage this risk and potentially prevent or detect cancer at an early stage when it is more treatable.
Examples of precancerous conditions include:
1. Dysplasia in the cervix (cervical intraepithelial neoplasia or CIN)
2. Atypical ductal hyperplasia or lobular hyperplasia in the breast
3. Actinic keratosis on the skin
4. Leukoplakia in the mouth
5. Barrett's esophagus in the digestive tract
Regular medical check-ups, screenings, and lifestyle modifications are crucial for individuals with precancerous conditions to monitor their health and reduce the risk of cancer development.
'Cell Transformation, Neoplastic' is the irreversible and unregulated process by which normal cells acquire the ability to proliferate and grow in an autonomous manner, leading to the formation of a neoplasm or tumor.
Neoplastic cell transformation is a process in which a normal cell undergoes genetic alterations that cause it to become cancerous or malignant. This process involves changes in the cell's DNA that result in uncontrolled cell growth and division, loss of contact inhibition, and the ability to invade surrounding tissues and metastasize (spread) to other parts of the body.
Neoplastic transformation can occur as a result of various factors, including genetic mutations, exposure to carcinogens, viral infections, chronic inflammation, and aging. These changes can lead to the activation of oncogenes or the inactivation of tumor suppressor genes, which regulate cell growth and division.
The transformation of normal cells into cancerous cells is a complex and multi-step process that involves multiple genetic and epigenetic alterations. It is characterized by several hallmarks, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, enabling replicative immortality, induction of angiogenesis, activation of invasion and metastasis, reprogramming of energy metabolism, and evading immune destruction.
Neoplastic cell transformation is a fundamental concept in cancer biology and is critical for understanding the molecular mechanisms underlying cancer development and progression. It also has important implications for cancer diagnosis, prognosis, and treatment, as identifying the specific genetic alterations that underlie neoplastic transformation can help guide targeted therapies and personalized medicine approaches.
Neoplasms are abnormal growths of cells or tissues that form tumors, which can be benign (noncancerous) or malignant (cancerous), and have the potential to invade local tissues and spread to distant sites in the body.
Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.
Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.
Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.
Neoplastic gene expression regulation refers to the control of genetic information flow and protein synthesis in neoplasms (abnormal tissue growths), which can involve various molecular mechanisms leading to altered gene expression profiles that contribute to cancerous phenotypes and progression.
Neoplastic gene expression regulation refers to the processes that control the production of proteins and other molecules from genes in neoplastic cells, or cells that are part of a tumor or cancer. In a normal cell, gene expression is tightly regulated to ensure that the right genes are turned on or off at the right time. However, in cancer cells, this regulation can be disrupted, leading to the overexpression or underexpression of certain genes.
Neoplastic gene expression regulation can be affected by a variety of factors, including genetic mutations, epigenetic changes, and signals from the tumor microenvironment. These changes can lead to the activation of oncogenes (genes that promote cancer growth and development) or the inactivation of tumor suppressor genes (genes that prevent cancer).
Understanding neoplastic gene expression regulation is important for developing new therapies for cancer, as targeting specific genes or pathways involved in this process can help to inhibit cancer growth and progression.
Peutz-Jeghers Syndrome is a rare genetic disorder characterized by the development of multiple benign hamartomatous polyps in the gastrointestinal tract and pigmented macules on the skin and mucous membranes, which predisposes affected individuals to an increased risk of gastrointestinal cancer and other associated malignancies.
Peutz-Jeghers Syndrome (PJS) is a rare genetic disorder characterized by the development of benign tumors called hamartomas in the gastrointestinal tract and pigmented macules on the skin and mucous membranes. The syndrome is caused by mutations in the STK11/LKB1 gene, which is involved in regulating cell growth and division.
Individuals with PJS have an increased risk of developing various types of cancer, including gastrointestinal tract cancers, breast cancer, ovarian cancer, lung cancer, and cervical cancer. The diagnosis of PJS is typically made based on the presence of characteristic clinical features, such as multiple pigmented macules on the skin and mucous membranes, and a history of benign gastrointestinal tumors or family history of PJS.
Management of PJS involves regular surveillance for gastrointestinal tumors and cancer screening, as well as genetic counseling and testing for family members who may be at risk. Treatment options depend on the location and size of the tumors and may include endoscopic removal or surgery.
Dental amalgam is a restorative material used in dentistry, typically consisting of a mixture of mercury with silver, tin, copper and other metals to form a hard-wearing, safe and durable filling, suited for posterior teeth restoration where biting forces are high.
Dental amalgam is a commonly used dental filling material that consists of a mixture of metals, including silver, tin, copper, and mercury. The mercury binds the other metals together to form a strong, durable, and stable restoration that is resistant to wear and tear. Dental amalgam has been used for over 150 years to fill cavities and repair damaged teeth, and it remains a popular choice among dentists due to its strength, durability, and affordability.
However, there has been some controversy surrounding the use of dental amalgam due to concerns about the potential health effects of mercury exposure. While the majority of scientific evidence suggests that dental amalgam is safe for most people, some individuals may be more sensitive to mercury and may experience adverse reactions. As a result, some dentists may recommend alternative filling materials, such as composite resin or gold, for certain patients.
Overall, dental amalgam is a safe and effective option for filling cavities and restoring damaged teeth, but it is important to discuss any concerns or questions with a qualified dental professional.
'Pigmentation' medically refers to the coloration of skin, hair, or eyes resulting from the presence of melanin or other pigments produced by cells called melanocytes.
Pigmentation, in a medical context, refers to the coloring of the skin, hair, or eyes due to the presence of pigment-producing cells called melanocytes. These cells produce a pigment called melanin, which determines the color of our skin, hair, and eyes.
There are two main types of melanin: eumelanin and pheomelanin. Eumelanin is responsible for brown or black coloration, while pheomelanin produces a red or yellow hue. The amount and type of melanin produced by melanocytes can vary from person to person, leading to differences in skin color and hair color.
Changes in pigmentation can occur due to various factors such as genetics, exposure to sunlight, hormonal changes, inflammation, or certain medical conditions. For example, hyperpigmentation refers to an excess production of melanin that results in darkened patches on the skin, while hypopigmentation is a condition where there is a decreased production of melanin leading to lighter or white patches on the skin.
'Skin pigmentation' is the process or result of melanin production and deposition in the skin, determining its color intensity and distribution.
Skin pigmentation is the coloration of the skin that is primarily determined by two types of melanin pigments, eumelanin and pheomelanin. These pigments are produced by melanocytes, which are specialized cells located in the epidermis. Eumelanin is responsible for brown or black coloration, while pheomelanin produces a red or yellow hue.
The amount and distribution of melanin in the skin can vary depending on genetic factors, age, sun exposure, and various other influences. Increased production of melanin in response to UV radiation from the sun helps protect the skin from damage, leading to darkening or tanning of the skin. However, excessive sun exposure can also cause irregular pigmentation, such as sunspots or freckles.
Abnormalities in skin pigmentation can result from various medical conditions, including albinism (lack of melanin production), vitiligo (loss of melanocytes leading to white patches), and melasma (excessive pigmentation often caused by hormonal changes). These conditions may require medical treatment to manage or improve the pigmentation issues.
Pigmentation disorders are conditions that affect the production or distribution of melanin, the pigment responsible for skin, hair, and eye color, leading to changes in the color of these bodily features.
Pigmentation disorders are conditions that affect the production or distribution of melanin, the pigment responsible for the color of skin, hair, and eyes. These disorders can cause changes in the color of the skin, resulting in areas that are darker (hyperpigmentation) or lighter (hypopigmentation) than normal. Examples of pigmentation disorders include melasma, age spots, albinism, and vitiligo. The causes, symptoms, and treatments for these conditions can vary widely, so it is important to consult a healthcare provider for an accurate diagnosis and treatment plan.
A death certificate is an official document issued by a medical practitioner or coroner, which declares and provides details of the time, place, cause, and circumstances of a deceased individual's death, serving legal purposes for estate settlement, insurance claims, and public health statistics.
A death certificate is a formal legal document that records the date, location, and cause of a person's death. It is typically issued by a medical professional, such as a physician or medical examiner, and is used to establish the fact of death for legal purposes. The information on a death certificate may be used for a variety of purposes, including settling the deceased person's estate, assisting with insurance claims, and supporting public health surveillance and research.
In order to complete a death certificate, the medical professional must determine the cause of death and any significant contributing conditions. This may involve reviewing the deceased person's medical history, conducting a physical examination, and ordering laboratory tests or autopsy. The cause of death is typically described using standardized codes from the International Classification of Diseases (ICD).
It is important to note that the information on a death certificate is considered confidential and is protected by law. Only authorized individuals, such as the deceased person's next of kin or legal representative, are permitted to access the document.
A hamartoma is a benign tumor-like growth, consisting of an overgrowth of mature cells and tissues that are native to the part of the body where the growth occurs, typically showing disorganized arrangement but normal differentiation.
A hamartoma is a benign tumor-like growth that is composed of an unusual mixture of cells and tissues that are normally found in the affected area. These growths can occur anywhere in the body, but they are most commonly found in the skin, lungs, and brain. Hamartomas are typically slow growing and do not spread to other parts of the body (metastasize). They are usually harmless, but in some cases, they may cause symptoms or complications depending on their size and location. In general, hamartomas do not require treatment unless they are causing problems.
SOX18
Olbromski M, Podhorska-Okołów M, Dzięgiel P. (2018). "Role of the SOX18 protein in neoplastic processes". Oncology Letters. 16 ...
Dysplasia
... is often indicative of an early neoplastic process. The term dysplasia is typically used when the cellular ...
Inguinal lymphadenopathy
It can be a symptom of infective or neoplastic processes. Infective aetiologies include Tuberculosis, HIV, non-specific or ... Neoplastic aetiologies include lymphoma, leukaemia and metastatic disease from primary tumours in the lower limb, external ...
Progastrin
"Post-translational processing of gastrin in neoplastic human colonic tissues". Biochemical and Biophysical Research ... Singh, P.; Xu, Z.; Dai, B.; Rajaraman, S. (1994-03-01). "Incomplete processing of progastrin expressed by human colon cancer ... Both sulfation and phosphorylation play a role in the maturation process: they increase the maturation of progastrin. While ... Caplin, M.; Savage, K.; Khan, K.; Brett, B. (2000-08-01). "Expression and processing of gastrin in pancreatic adenocarcinoma: ...
HPG80
Post-translational processing of gastrin in neoplastic human colonic tissues. Elsevier. OCLC 894059948.{{cite book}}: CS1 maint ... This process is called neo-angiogenesis. In 2015, hPG80 was shown to be a pro-angiogenic factor. Indeed, hPG80 stimulates ... Caplin, M.; Savage, K.; Khan, K.; Brett, B.; Rode, J.; Varro, A.; Dhillon, A. (2000-08-01). "Expression and processing of ... van Solinge, W. W.; Odum, L.; Rehfeld, J. F. (1993-04-15). "Ovarian cancers express and process progastrin". Cancer Research. ...
Failed back syndrome
A variety of causes exist, including infectious, inflammatory, and neoplastic processes. Infectious causes include bacterial, ... Noninfectious inflammatory processes include surgery, intrathecal hemorrhage, and the administration of intrathecal (inside the ... and NSAIDs have limited value to intervene in TNF-mediated processes. An alternative often employed is the injection of ...
Temple Fay
He noted satisfactory responses for both infectious and neoplastic disease processes. ... He also experimented with whole-head ...
Arachnoiditis
... and neoplastic processes. Infectious causes include bacterial, viral, fungal, and parasitic agents. Prior spinal surgery has ... Other noninfectious inflammatory processes include surgery, intrathecal hemorrhage, and the administration of anesthetics (e.g ...
Computed tomography of the thyroid
They can be symptomatic, asymptomatic, diffuse, focal, neoplastic, or non-neoplastic processes. Neck ultrasound (US), with the ... Therefore, moderate thyroid enhancement in a case of thyroiditis suggests a diffuse inflammatory process. It is essential to ... which favour a benign process such as colloid cysts (Figs. 1 and 2). In a retrospective review of preoperative CT scan, 35% ( ...
Disseminated disease
... refers to a diffuse disease-process, generally either infectious or neoplastic. The term may sometimes ... a process known as metastasis). Disseminated disease is often contrasted with localized disease. Summerbell, R.C.; Richardson, ...
Secreted frizzled-related protein 1
... can contribute to the neoplastic process. This led Fukuhara et al. to investigate whether SFRP1 is associated with the ... The angiogenic process is complex and involves endothelial cell (EC) movement and proliferation. SFRP1 has been shown to have a ... This process is catalyzed by DNA methyltransferase. In numerous cancers, the CpG islands of selected genes are aberrantly ... Neoplastic epithelial cells were treated with lithium chloride, which inhibits GSK3B and thus stabilizes B-catenin. Lithium ...
Somatic evolution in cancer
Neoplastic progression - the somatic evolutionary process by which normal tissue changes into malignant (cancerous) tissue. ... and so may account for many of the changes during neoplastic progression (the process by which normal tissue becomes cancerous ... The evolutionary processes do not cease when a population of cancer stem cells arises in a tumor. Cancer treatment drugs pose a ... In the process of the treatment, cancer cells are most likely to evolve some form of resistance to the bacterial treatment. ...
Mir-216 microRNA precursor family
"MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma". ...
Luigi Mangiagalli
His studies focused on the relationship between heart disease, pregnancy and surgery in neoplastic processes. He promoted many ...
Hyperplasia
Atypical endometrial hyperplasia may represent an early neoplastic process which can lead to endometrial adenocarcinoma. The ... That being said, the effects caused by pathologic hyperplasia can provide a suitable foundation from which neoplastic cells may ... This differs from neoplasia (the process underlying cancer and benign tumors), in which genetically abnormal cells manage to ...
Leukostasis
... is different from leukemic infiltration, which is a neoplastic process where leukemic cells invade organs. ... Serum potassium levels may also be artificially elevated by a release from leukemic blasts during in vitro clotting process, ...
X-inactivation
July 2014). "The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process". Virchows ... During the inactivation process, the future Xa ceases to express Xist, whereas the future Xi dramatically increases Xist RNA ... The timing of each process depends on the species, and in many cases the precise time is actively debated. [The whole part of ... X-inactivation (also called Lyonization, after English geneticist Mary Lyon) is a process by which one of the copies of the X ...
Langerhans cell histiocytosis
While clonality is an important attribute of cancer, its presence does not prove that a proliferative process is neoplastic. ... There are ongoing investigations to determine whether LCH is a reactive (non-cancerous) or neoplastic (cancerous) process. ... treatment of subset of disseminated disease using chemotherapeutic regimens are all consistent with a neoplastic process. In ... of LCH as a monoclonal proliferation provided additional support for the neoplastic origin of this disease. ...
Buccal exostosis
This bone will then be sent for histopathological examination to differentiate from benign to malignant neoplastic processes. ...
Osteonecrosis of the jaw
... and metabolic and neoplastic processes. The limitations apply to all imaging modalities, including plain radiography, ... This process is commonly called remodelling. However, osteoporosis is essentially the result of a lack of new bone formation in ... Bone infarcts as well as damage to the deeper portion of the cancellous bone is an insidious process. It is certainly not ... When practitioners have an up-to-date understanding of the disease process and a good medical history is combined with detailed ...
Parotitis
These nodes may be involved with any process that affects lymph nodes, including bacterial, fungal, viral, and neoplastic ... processes. Rarely, drugs such as iodides, phenylbutazone, thiouracil, isoproterenol, heavy metals, sulfisoxazole, and ...
Slipping rib syndrome
... or neoplastic processes. A condition referred to as twelfth rib syndrome is similar to slipping rib syndrome; however, it ...
FEDOR
... ability of the cerebral cortex to spontaneously and modulated reorganization of neuronal networks due to neoplastic processes. ... As a result, the patient imagines the sensation of movement, and the exoskeleton produces it, the process of the brain's ...
Stafne defect
No treatment is required, but neoplastic processes (metastatic malignancy to the submandibular lymph nodes and/or salivary ...
Spurling's test
... and those with other neoplastic or infectious processes. Cervical instability is also a reason to avoid performing this medical ...
Neoplasm
Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is referred to as a neoplastic process. The ... If the general process by which sporadic colon cancers arise is the formation of a pre-neoplastic clone that spreads by natural ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ... Neoplastic tumors are often heterogeneous and contain more than one type of cell, but their initiation and continued growth is ...
Amelanotic melanoma
Often, amelanotic melanomas are mistaken for benign lesions, including dermatitis, benign neoplastic processes, or a different ...
Hyaluronan synthase
The loss of this regulatory site in rodent models drives neoplastic processes, increased pro-remodeling phenotypes, and the ... Following this process, the displaced UDP dissociates from the other active site domain. The process of monomer binding and ... During the processes of intravasation or extravasation, the interaction of HAS produced HA with receptors such as CD44 or RHAMM ... HA's interaction with CD44 activates focal adhesion kinase (FAK), an important molecule in the process of cell motility by ...
Ground-glass opacity
... or a neoplastic process. When a substance other than air fills an area of the lung it increases that area's density. On both x- ... It is important to note that while some disease processes present as only one pattern, many can present with a mixture of GGO ... Lee HY, Choi YL, Lee KS, Han J, Zo JI, Shim YM, Moon JW (March 2014). "Pure ground-glass opacity neoplastic lung nodules: ...
Cancer Epidemiology, Biomarkers & Prevention
... the use of biomarkers to study the neoplastic and preneoplastic processes in humans, chemoprevention and other types of ...
Neoplastic Processes (medical concept explorer)
Disorders of Oral Pigmentation: Background, Pathophysiology, Etiology
... and neoplastic processes (eg, melanoma). ... This process shows a strong predilection for Black patients (82 ... Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa. Head Neck Pathol. 2019 Mar. 13 (1):47-55. [QxMD MEDLINE Link] ... 3] It is not clear if the melanotic macule represents a physiologic or reactive process, and a genetic predisposition has been ... 19] It is not clear if these lesions represent a physiologic or reactive process, and a genetic predisposition has also been ...
CO2: Immunopathologies, Inflammatory Rheumatic Diseases and Biomarkers in Neoplastic Processes - INiBICA
CO2: Immunopathologies, Inflammatory Rheumatic Diseases and Biomarkers in Neoplastic Processes. Our group arises from the close ... The maturation process from B lymphocytes to CPs goes through a series of phases in which the physiological and phenotypic ... The proteins that make up the cellular secretory machinery are involved in any cellular secretion process, including everything ... key in this cell differentiation process. The expression of alternative isoforms to PRDM1 has been over-expressed in multiple ...
SUPR-3D: Simple Unplanned Palliative Radiotherapy Versus 3D Conformal Radiotherapy for Patients With Bone Metastases | Clinical...
Pathologic Processes , SUPR-3D: Simple Unplanned Palliative Radiotherapy Versus 3D Conformal Radiotherapy for Patients With ... Clinical trial for Neoplastic Processes , Neoplasms , Neoplasm Metastasis , ... Neoplasm Metastasis, Neoplastic Processes, Neoplasms, Pathologic Processes Treatment. VMAT, SUPR Clinical Study Identifier. ... By sending a message, I agree that my data will be sent to a representative for the selected site and processed in accordance ...
SOX18 - Wikipedia
The trafficking of neoplastic cells represents a key process that contributes to progression of hematologic malignancies - The...
The trafficking of neoplastic cells represents a key process that contributes to progression of hematologic malignancies. * ... The trafficking of neoplastic cells represents a key process that contributes to progression of hematologic malignancies. at ... In this review, we provide a view of the molecular players that regulate the trafficking of neoplastic cells during development ... Integrin activation is a dynamic process that can be achieved by several stimuli from outside (outside-in) or inside (inside- ...
Disorders of Oral Pigmentation: Background, Pathophysiology, Etiology
... and neoplastic processes (eg, melanoma). ... This process shows a strong predilection for Black patients (82 ... Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa. Head Neck Pathol. 2019 Mar. 13 (1):47-55. [QxMD MEDLINE Link] ... 3] It is not clear if the melanotic macule represents a physiologic or reactive process, and a genetic predisposition has been ... 19] It is not clear if these lesions represent a physiologic or reactive process, and a genetic predisposition has also been ...
Uveitis Classification: Classification Systems, Classification Parameters, Patient Demographics
Infiltrative - Referring to invasive neoplastic processes. *. Injurious - Trauma commonly seen in general offices ... A useful technique to classify an inflammatory process, or any process within the eye for that matter, uses the 7 "I" system. ... Localization of the Inflammatory Process. The anatomical location of the inflammatory process is one of the most important ... Meshing is the process of matching up the findings in the case in question with the clinical characteristics of known uveitic ...
Difference between revisions of "BioPortal REST services" - NCBO Wiki
Neoplastic Process,/string, ,/list, ,/entry, ,entry, ,string,SubClass,/string, ,list, ,classBean, ,id,Non-Cutaneous_Melanoma,/ ... NOTE: To see which ontology versions have been processed for use with the Hierarchy services, see http://rest.bioontology.org/ ... neoplastic melanocytes.,/string, ,/definitions, ,relations, ,entry, ,string,UMLS_CUI,/string, ,list, ,string,C0025202,/string ... NOTE: To see which ontology versions have been processed for use with the Hierarchy services, see http://rest.bioontology.org/ ...
BioPortal REST services - NCBO Wiki
Neoplastic Process,/string, ,/list, ,/entry, ,entry, ,string,SubClass,/string, ,list, ,classBean, ,id,Non-Cutaneous_Melanoma,/ ... NOTE: To see which ontology versions have been processed for use with the Hierarchy services, see http://rest.bioontology.org/ ... neoplastic melanocytes.,/string, ,/definitions, ,relations, ,entry, ,string,UMLS_CUI,/string, ,list, ,string,C0025202,/string ... NOTE: To see which ontology versions have been processed for use with the Hierarchy services, see http://rest.bioontology.org/ ...
Benign Lesions of the Ovaries: Dysfunctional Ovarian Cysts, Benign Epithelial Neoplastic Ovarian Cysts, Benign Solid Ovarian...
These cysts arise from temporary pathologic variations of a normal physiologic process and are not neoplastic. ... These cysts arise from temporary pathologic variations of a normal physiologic process and are not neoplastic. The tumors ... Benign Epithelial Neoplastic Ovarian Cysts. Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. One ... Ultrasonographic characteristics of PID vary and are related to the stage of the disease process. A pyosalpinx (pus-filled ...
Multivariate regression analyses of data from a randomised, double-blind, placebo-controlled study confirm quality of life...
Inflammation - Ontology Browser - Rat Genome Database
Neoplastic Processes + nephrotoxicity Nerve Degeneration + ochronosis + Orofacial Granulomatosis Pathological Protein ... A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical ... Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes ...
Shock - Ontology Browser - Rat Genome Database
Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer | Nature Communications
IHC indicates low expression of cystatin-B in neoplastic islands from the ITF as an independent marker for local recurrence. ... Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) ... Cellular metabolic processes primarily represented the neoplastic island proteins, whereas cellular adhesion processes and ... among other overrepresented processes, metabolic processes for proteins upregulated in neoplastic islands ...
Advanced Search Results - Public Health Image Library(PHIL)
Gordonia bronchialis-Associated Endophthalmitis, Oregon, USA - Volume 25, Number 5-May 2019 - Emerging Infectious Diseases...
For State, Local, Territorial, and Tribal Health Departments | Electronic Cigarettes | Smoking & Tobacco Use | CDC
Basic Principles for the Interpretation of Cytological Preparations - WSAVA2009 - VIN
Neoplastic Processes For differentiation between malignant tumors and benign tumors or hyperplasia, both general criteria and ... But it can also be a secondary inflammation in a neoplastic process. It is thus important even in the presence of inflammatory ... The inflammatory process can further be characterized by the presence or absence of degenerative changes in the inflammatory ... If this pyknotic nucleus disintegrates, the process is called karyorrhexis. In a granulomatous inflammation there are fewer ...
Erythrocytes: Overview, Morphology, Quantity | IVIS
This anemia can be associated with infections, neoplastic processes, and immune disorders. ... May be caused by both neoplastic and non-neoplastic diseases.. *The most common neoplastic causes are the hematopoietic and ... The principal non-neoplastic cause is myelofibrosis, the replacement of marrow spaces by connective tissue (Fig. 4-44). ...
Acquired Cystic Disease-Associated Renal Cell Carcinoma - CISMeF
Pathology in Practice in: Journal of the American Veterinary Medical Association Volume 244 Issue 12 ()
Very few neoplastic processes in owls (particularly screech owls) have been documented. For great horned owls (Bubo virginianus ... Chapter 15: neoplastic diseases. In: Diseases of poultry. 11th ed. Ames, Iowa: Iowa State Press, 2003; 465-489. ... Chapter 15: neoplastic diseases. In: Diseases of poultry. 11th ed. Ames, Iowa: Iowa State Press, 2003; 465-489. ... Chapter 15: neoplastic diseases. In: Diseases of poultry. 11th ed. Ames, Iowa: Iowa State Press, 2003; 465-489. ...
Time for evidence-based cytology - CytoJournal
The first essential stage in evidence-seeking process is formulating or focusing our question/s. This will help us to use our ... So we can say that a cytologic test may improve the overall diagnostic process, therapeutic strategy, and economic benefit. In ... and the outcome of the cytologic test is part of the decision making process that lead to an improved outcome in clinical ... and ANN for discriminating benign from malignant nuclei and lesions of the lower urinary tract on images of routinely processed ...
Diseases Affecting the Equine Vertebral Column - The Horse
Neoplastic processes impacting the vertebral column included primary vertebral body sarcoma, metastatic lymphosarcoma, and ... Articular process joint lesions were the most frequent cause of spinal cord compression (n=71) followed by subluxation of the ... A variety of disease processes can impact the equine vertebral column. Pathologic evaluation of the equine vertebral column in ... Articular process lesions were largely due to osteoarthritis, followed by osteochondrosis. ...
Canine Spirocercosis and Associated Neoplasia - WSAVA2007 - VIN
During this process, chronically inflamed tissue undergoes a neoplastic transformation. Local esophageal neoplasia with ... Neoplastic transformation of S. lupi granulomas to fibrosarcoma or osteosarcoma is a frequent finding associated with ... Neoplastic transformation occurs in the granulomatous tissue of some infected dogs which develop a Spirocerca-associated ... However, neoplastic masses in the esophagus commonly look irregular and ulcerated whereas granulomas tend to have smooth ...
![CARTPT CART prepropeptide [Homo sapiens (human)] - Gene - NCBI](data:image/png;base64,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)
CARTPT CART prepropeptide [Homo sapiens (human)] - Gene - NCBI
... and Amphetamine-Regulated Transcript-Containing Neural Structures in the Human Colon Affected by the Neoplastic Process. ... Process. Evidence Code. Pubs. involved_in G protein-coupled receptor signaling pathway ISS Inferred from Sequence or Structural ... This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These ...
Cancers | Free Full-Text | Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine...
... in biliary BAs in these patients could be related to mechanisms more specifically associated with the neoplastic process. For ... All the process was performed in less than 2 h. Serum samples from all patients were also obtained at the time of ERCP and ... Article Processing Charges Pay an Invoice Open Access Policy Contact MDPI Jobs at MDPI ... Data were pre-processed using the TargetLynx application manager for MassLynx 4.1 software (Waters Corp., Milford, CT, USA). ...
Histiocytoses
LCH of the lung is a heterogenous group of lesions thought to be a reactive rather than neoplastic process. The histogenesis of ... Whether Langerhans cell histiocytosis is a neoplastic disorder or a reactive process remains controversial. The true nature of ... This might suggest that LCH is a neoplastic rather than a reactive process. ... All neoplastic histiocytosis X cells were positive for S-100 protein and peanut agglutinin but were negative for Mac-387. ...
Key concepts in glioblastoma therapy | Journal of Neurology, Neurosurgery & Psychiatry
Interestingly, glioblastomas capacity to suppress immune response appears intimately associated with the process of neoplastic ... In terms of the non-neoplastic cell types shown to facilitate neoplastic information, they can generally be divided into three ... Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 2010; ... These changes result in the release of growth factors that further enable and sustain neoplastic transformation57 or lead to ...
Goats diagnosed with neoplasia display variability in clinical presentations, treatments, and outcomes in: Journal of the...
... for goats diagnosed with neoplasia and highlighted the challenges associated with the wide variety of neoplastic processes ... ANIMALS 46 goats with a definitive diagnosis of ≥ 1 neoplastic process admitted over a 15-year period. PROCEDURES Medical ... Summary of goats presented to a veterinary teaching hospital with a confirmed neoplastic process based on location of the tumor ... 46 goats with a definitive diagnosis of ≥ 1 neoplastic process admitted over a 15-year period. ...
MalignantMelanomaTumorsPhysiologicTransformationHyperplasticLesionsMammaryInfectiousTumorMetastasisProgressionClinicalCytologyHomogeneousCellularDifferentialTissueInfectionsScanBenignCellsDisease processesMechanismsChemicalClassificationCellResultIntracellularCancerCommonSolidComplexImageDevelopmentLargeGenerally
Malignant8
- In this review, we provide a view of the molecular players that regulate the trafficking of neoplastic cells during development and progression of MM, CLL, and ALL, together with current therapies that target the malignant cells. (globaltechbiz.com)
- The first is determining the tissue of origin, the second is differentiating among inflammation, hyperplasia/benign tumor and malignant tumor, and the third is classifying the inflammatory process or the tumor. (vin.com)
- This necessary in order to rule out the chance of a malignant process. (wdxcyber.com)
- As long as there are not excrescences with areas of irregular solid mixed with cystic, this is still unlikely to be a malignant process. (wdxcyber.com)
- Neoplastic meningitis can be an elusive diagnosis, so clinician awareness is important so that this malignant manifestation is recognized in a timely manner. (medscape.com)
- Neoplastic meningitis is characterized by the diffuse involvement of the leptomeninges (pia and arachnoid), the subarachnoid space, and the cerebrospinal fluid (CSF) by malignant cells, and it occurs through the hematogenous invasion of the subarachnoid space and ventricles or through direct extension from bone and brain lesions, or, in some cases, with local spread through the dura along perineural and perivascular spaces. (medscape.com)
- [ 3 ] The most frequent primary solid tumors associated with neoplastic meningitis are breast cancer, non-small-cell lung cancer, and malignant melanoma. (medscape.com)
- We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)
Melanoma3
- The four major mechanisms leading to increased oral pigmentation are discussed in detail: physiologic pigmentation, systemic diseases (eg, Peutz-Jeghers syndrome [PJS]), oral mucosal insults (eg, amalgam tattoo), and neoplastic processes (eg, melanoma). (medscape.com)
- The process of metastasis is the consequence of migration of melanoma cells from the primary lesion, to locoregional and distant body sites via the lymphatic circulation and the bloodstream. (hindawi.com)
- Four different types of oral pigmentation are described in detail to illustrate the 4 major mechanisms leading to increased oral pigmentation: oral pigmentation due to intrinsic processes (eg, Peutz-Jeghers syndrome), oral pigmentation due to extrinsic processes (eg, amalgam tattoo), oral pigmentation due to hyperplastic or neoplastic processes (eg, melanoma), and iatrogenic oral pigmentation (eg, smoker melanosis). (medscape.com)
Tumors2
- The tumors result from either failure of a dominant mature follicle to rupture or failure of an immature follicle to undergo the normal process of atresia. (medscape.com)
- The presence of neoplastic islands, classified as large or small according to the number of cells in the ITF, has been described as the most aggressive pattern compared to tumors with a more uniform growth pattern, as tumor invasion occurs in a more widespread manner as cellular islands or single cells 4 . (nature.com)
Physiologic5
- These cysts arise from temporary pathologic variations of a normal physiologic process and are not neoplastic. (medscape.com)
- This normal physiologic process however can appear abnormal and thus this is a frequently occurring set up problems. (wdxcyber.com)
- Regression would indicate that the cyst was due to a physiologic process that may well resolve on its own. (wdxcyber.com)
- The presence of solid components increases the likelihood of a neoplastic process rather than a physiologic process of the ovary. (wdxcyber.com)
- These still may represent physiologic processes of the ovary or even the bowel with stool contents. (wdxcyber.com)
Transformation5
- Neoplastic transformation occurs in the granulomatous tissue of some infected dogs which develop a Spirocerca -associated sarcoma. (vin.com)
- Cancer is a multi-factorial process involving genetic and epigenetic events which result in neoplastic transformation. (oregonstate.edu)
- Some evidence suggests that dissolution of IONP following endocytosis into cells may disrupt iron homeostasis, resulting in genotoxicity and neoplastic-like cellular transformation. (cdc.gov)
- Human bronchial epithelial cells (Beas2B) were continuously exposed to nFe2O3 or nano-SiO2 coated nFe2O3 (SiO2-nFe2O3) for up to 6.5 months at an occupationally relevant low dose (0.6 microg/cm2 or 2.88 microg/mL) and evaluated over time for indications of neoplastic-like transformation and its underlying mechanism. (cdc.gov)
- Our results showed that beginning at four months, nFe2O3-exposed Beas2B underwent neoplastic-like transformation, as indicated by increased cell proliferation and attachment-independent colony formation. (cdc.gov)
Hyperplastic1
- [ 5 ] The investigators found "an arbitrary continuum of morphologic structure links normal [TDLUs] and/or lobules to the entire group of dysplastic, metaplastic, hyperplastic, anaplastic, and neoplastic human mammary lesions, with the exception of intraductal papillomas and rarely occurring hyperplasias of larger ducts. (medscape.com)
Lesions3
- Non neoplastic proliferative processes (NNPP) are lesions frequently found in the oral cavity and in general, they are characterized by inflammatory processes causing tissue proliferation 1 . (bvsalud.org)
- Knowledge of non neoplastic proliferative processes is of the utmost importance because their causes, which may be prevented by clinical procedures, are present in day to day clinical practice of dentists, thus promoting the appearance of these lesions. (bvsalud.org)
- Among the non neoplastic proliferative processes, fibrous hyperplasia, pyogenic granuloma, and peripheral giant cell lesions should be emphasized because they are frequently found in the oral soft tissues. (bvsalud.org)
Mammary1
- Experimental studies have demonstrated that mammary cancer is a hormone-dependent multistep process that can be induced by a variety of compounds and mechanisms, that is, hormones, chemicals, radiation, and viruses, in addition to or in combination with genetic factors. (eurekamag.com)
Infectious2
- Evaluation for common infectious etiologies when also suspected should be pursued and less common infections, and rheumatologic or neoplastic processes considered, as clinically indicated. (cdc.gov)
- While inguinal hernia is common in the primary care office, the differential diagnosis is extensive and includes infectious, inflammatory and neoplastic processes. (harvard.edu)
Tumor4
- Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. (nature.com)
- left) the default state of the cell is quiescence, and a genetic event in the cell triggers a unidirectional, irreversible and deterministic process that leads to tumor expansion and dissemination. (elifesciences.org)
- They may interact with tumor cells to influence growth and NEOPLASTIC PROCESSES. (bvsalud.org)
- [ 5 ] However, neoplastic meningitis is expected to occur more frequently in the future because longer cancer survival times allow tumor cells the time needed to penetrate so-called central nervous system (CNS) sanctuary sites. (medscape.com)
Metastasis1
- The process of metastasis involves the spread of neoplastic cells to locoregional or distant body sites via lymphatic vessels and/or bloodstream. (hindawi.com)
Progression1
- This reversed proton gradient is driven by a series of proton export mechanisms that underlie the initiation and progression of the neoplastic process. (benthamscience.com)
Clinical6
- The naming process creates a profile or template of the clinical case. (medscape.com)
- Cytology is a useful clinical tool for investigation of disease processes, and the techniques and their interpretation have developed into an entire discipline. (merckvetmanual.com)
- The aetiology, pathogenesis and clinical presentation of all reactive, infective and neoplastic processes involving the head and neck and specifically the oral cavity are studied. (up.ac.za)
- A literature review was conducted to summarize the clinical presentation, differential diagnosis, laboratory values, and imaging findings of neoplastic meningitis. (medscape.com)
- Neoplastic meningitis is an event in the course of cancer with a variable clinical presentation and a wide differential diagnosis. (medscape.com)
- However, both modalities do not always confirm the diagnosis of neoplastic meningitis despite a typical clinical picture. (medscape.com)
Cytology1
- Results of cytology analysis and flow cytometry were negative for neoplastic processes. (cdc.gov)
Homogeneous2
- The mass was homogeneous and well delimited, suggesting a neoplastic process. (ufrgs.br)
- Other diagnostic possibilities include astrocytoma, although this or other neoplastic processes would not likely have such a homogeneous appearance. (appliedradiology.com)
Cellular2
- The proteins that make up the cellular secretory machinery are involved in any cellular secretion process, including everything from exosomes to interleukins. (inibica.es)
- The application testosterone into your system the up-regulation or inhibition an associated cellular process. (mdtmag.com)
Differential1
- Thus, a specifically tailored, cost-effective uveitis evaluation may be obtained to further process the differential for a given constellation of parameters. (medscape.com)
Tissue1
- An epidemiological survey of oral soft tissue proliferative processes diagnosed at the center of Pathological Anatomy of Oral ASCES Faculty. (bvsalud.org)
Infections1
- It may be caused by infections, inflammatory, anatomic or neoplastic processes. (bvsalud.org)
Scan2
- Mammogram doubts neoplastic process, scan shows well lobulated solid mass,wider than taller,family history of 2 sis of breast cancer. (healthtap.com)
- A CT scan taken a few days later showed that a neoplastic process is a likely consideration. (svmic.com)
Benign1
- While it is possible that this represents a ovarian mass with mostly solid components, it is much more commonly a benign process involving the bowel, tube or adhesive disease around the ovary. (wdxcyber.com)
Cells4
- Integrins are the main adhesion receptors facilitating the trafficking of neoplastic cells. (globaltechbiz.com)
- Integrin activation is a dynamic process that can be achieved by several stimuli from outside (outside-in) or inside (inside-out) the cell, a property that highlights the integrin role as main BACE1-IN-1 connectors between the BACE1-IN-1 cancer cells and their environment (24). (globaltechbiz.com)
- Although their derivation was long debated, neoplastic cells characteristically express cytoplasmic immunoglobulin and may produce primary amyloid, leaving little doubt as to their lymphoplasmacytic origin. (merckvetmanual.com)
- Treated cells undergo a remarkable shift in structure, acquiring an astrocyte-like morphology with star-shaped bodies and radial branched processes. (lu.se)
Disease processes1
- Anatomical Pathology includes the study of the microscopic, macroscopic, biochemical and immunological disease processes of the organs and tissues. (up.ac.za)
Mechanisms1
- This goal, however, cannot be accomplished until the specific agent(s) or mechanisms that initiate the neoplastic process are identified. (eurekamag.com)
Chemical1
- A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. (mcw.edu)
Classification1
- Les complications orbitaires sont traitées par des antibiotiques visant les bactéries en cause avec des indications chirurgicales selon la classification scannographique de Chandler. (ajol.info)
Cell1
- We live and we develop throughout those dynamics, in which interact in a permanent way organization processes, promoting life, and disorganization ones, which lead to death, for example in cell proliferation and apoptosis, in neoplastic processes of indifference, in the complexity of the psychic functions and the dissolution of thought and desire, among many others. (bvsalud.org)
Result1
- These genetic alterations result in either activation or inactivation of specific gene functions that contribute to the process of carcinogenesis. (bmj.com)
Intracellular2
- Evidences suggest that Ca 2+ channels TRP and Orai participate in the intracellular Ca 2+ signaling involved the physiological angiogenesis processes [17]. (researchgate.net)
- These outcomes correlated with nFe2O3 dissolution, increased intracellular iron, and genotoxicity, as well as significant changes in pathways related to DNA damage repair and autophagic processes. (cdc.gov)
Cancer2
- cancer is an evolving process, with different factors having different roles at different stages. (elifesciences.org)
- Clinicians treating patients with cancer should be aware of the possibility of neoplastic meningitis, especially when multilevel neurological symptoms are present. (medscape.com)
Common1
- Non neoplastic proliferative processes processes are found in the general population, more common in females, affecting wide age-range, predominantly in individuals in the fifth and sixth decades of life, and fibrous hyperplasia was the most frequently found lesion. (bvsalud.org)
Solid1
- Neoplastic meningitis is a complication of solid and hematological malignancies. (medscape.com)
Complex1
- The disadvantages of VMAT include more complex planning and quality assurance processes compared with SUPR. (centerwatch.com)
Image3
- Inset-Higher-magnification image of neoplastic myelocytes with abundant cytoplasm filled with eosinophilic granules. (avma.org)
- In this image, a neoplastic myelocyte with heterogeneous granules of variable size (maximum dimension, 0.25 to 1.9 μm) is visible. (avma.org)
- A changing image over that time period can confirm that the process is unlikely to be neoplastic. (wdxcyber.com)
Development1
- From the first moments of conception, during the intrauterine life, throughout the development and even in the death process, these dynamics fake the existence of each one, shaping the body and the subjectivity. (bvsalud.org)
Large1
- Men have always vitamins to remain in good very large and easily confused with a neoplastic process. (mdtmag.com)
Generally2
- [ 6 ] Molecular therapeutic agents, particularly monoclonal antibodies, generally do not penetrate the CNS, and their use could lead to increasing rates of neoplastic meningitis in patients receiving such agents. (medscape.com)
- A diagnosis of neoplastic meningitis is generally suggestive of advanced disease, and the overall prognosis is affected by controlling leptomeningeal disease. (medscape.com)