A syndrome characterized by lesions occurring on the face, scalp, or neck which consist of congenital hypoplastic malformations of cutaneous structures and which over time undergo verrucous hyperplasia. Additionally it is associated with neurological symptoms and skeletal, ophthalmological, urogenital, and cardiovascular abnormalities.
A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.
A macular lesion on the side of the FACE, involving the CONJUNCTIVA and EYELIDS, as well as the adjacent facial skin, SCLERA; OCULOMOTOR MUSCLES; and PERIOSTEUM. Histological features vary from those of a MONGOLIAN SPOT to those of a BLUE NEVUS.
Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)

Clinicopathologic analysis of 21 cases of nevus sebaceus: a retrospective study. (1/20)

BACKGROUND: Nevus sebaceus (NS), otherwise designated as 'organoid nevus', involves proliferative changes of the sebaceous glands, sweat glands, and the hair follicles. It displays a range of appearances, depending on the lesion's age. AIMS: To study the histopathological features of NS and correlate these with clinical findings. METHODS: All skin biopsy specimens over a 12-year period from 1995 to 2007 which had a diagnosis of NS were included. Clinical data with follow-up notes and histopathology were reviewed. RESULTS: Half of the cases had a verrucous clinical appearance, while the rest presented as papules, plaques, or patches. All the cases showed immature hair follicles, and 24% of cases showed immature sebaceous glands. Normal terminal hair follicles were characteristically absent in the lesion. Nineteen percent of the cases showed dilated apocrine glands, and 14% showed hyperplasia of eccrine glands. Epidermal changes in the form of acanthosis, papillomatosis, and hyperkeratosis were seen in 86% of cases. Dilated keratin-filled infundibula were observed in 24% of cases. One case was associated with a squamous cell carcinoma. CONCLUSIONS: Nevus sebaceus is a cutaneous hamartoma, consisting of various elements indigenous to the organ. Normal terminal hair follicles are characteristically absent in the lesion although the same may be seen in rest of the epidermis, a feature of diagnostic importance, not usually highlighted in literature. The divergent differentiation observed in NS is consistent with the common embryologic origin of the folliculosebaceous-apocrine unit and should not mislead the pathologist.  (+info)

Epidermal nevus syndrome associated with hypophosphatemic rickets. (2/20)

Epidermal Nevus Syndrome (ENS) is characterized by epidermal nevi associated with abnormalities involving the nervous, skeletal, and other systems. Rarely, hypophosphatemic rickets has been observed in association with epidermal nevi. A patient with ENS with right-sided serpiginous skin lesions, generalized weakness, and diffuse osteopenia associated with hypophosphatemic rickets is described. Medical management was enough to correct the clinical picture. The pathogenic mechanism involved in the onset of hypophosphatemic rickets in ENS is not fully clarified. Different studies suggest that phosphaturia, caused by circulating factor(s), called "phosphatonin(s)," may be secreted by an epidermal nevus. The nature of the phosphaturic factor(s) is not well understood, but elevated levels of circulating FGF-23 were recently reported in one patient with hypophosphatemic rickets. The authors suggest that serum FGF-23 measurement be included in the workup of this kind of rickets because there is growing evidence that in these situations the epidermal nevi produce a phosphaturic factor.  (+info)

A case of juvenile dermatomyositis manifesting inflammatory epidermal nevus-like skin lesions: unrecognized cutaneous manifestation of blaschkitis? (3/20)

 (+info)

Epidermal nevus. (4/20)

A healthy 25-year-old man presented with a widespread, non-organoid, non-epidermolytic epidermal nevus. In addition to extensive hyperpigented patches and thin plaques following Blaschko lines, there were superimposed psoriasiform plaques on the elbows and warty plaques on the upper trunk. Striate palmar keraoderma also was evident. We review the clinical morphologies, sites of involvement, histopathologic findings (presence or absence of epidermolytic hyperkeratosis), and syndromal associations of non-organoid EN with underlying mutations in different genes.  (+info)

Bilateral renal artery stenosis and epidermal nevus syndrome in a child. (5/20)

 (+info)

Dermoscopic aspects of syringocystadenoma papilliferum associated with nevus sebaceus. (6/20)

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Letter: Transient peripheral facial nerve paralysis after local anesthetic procedure. (7/20)

Complications may arise after laser therapy of the face. The most common ones are bleeding and infections; facial nerve paresis or paralysis is rarely reported. We describe a case of a transient peripheral facial nerve paralysis after laser therapy of an epidermal verrucous nevus localized at the left preauricular area.  (+info)

Extensive cerebriform nevus sebaceus: an unusual presentation. (8/20)

Nevus sebaceus is an epidermal nevi composed of sebaceous glands, which usually presents as single yellowish plaque over the head and neck. A rare morphological variant, namely cerebriform nevus sebaceus was first reported in 1998. As with other nevi, the occurrence of nevus sebaceous is related to genetic mosaicism and the shape and distribution of the nevus is determined by the stage at which mosaicism has arisen. We report a patient with cerebriform nevus sebaceus having an unusually widespread distribution over the head, face, and trunk, but without any other organ system involvement.  (+info)

A nevus sebaceous of Jadassohn is a type of congenital benign skin tumor or birthmark that is composed of epidermal, hair follicle, and sebaceous gland components. It typically appears as a yellowish, greasy, or warty plaque on the scalp or face during infancy or early childhood. The lesion tends to enlarge slowly and may undergo various changes in appearance over time.

In adolescence or adulthood, there is a risk of secondary tumor development within the nevus sebaceous, such as basal cell carcinoma, squamous cell carcinoma, or sebaceous carcinoma. Therefore, regular monitoring and possible surgical removal of the lesion may be recommended, especially in cases where the nevus is large, symptomatic, or shows signs of malignant transformation.

A nevus, also known as a mole, is a benign growth or mark on the skin that is usually brown or black. It can be raised or flat and can appear anywhere on the body. Nevi are made up of cells called melanocytes, which produce the pigment melanin. Most nevi develop in childhood or adolescence, but they can also appear later in life. Some people have many nevi, while others have few or none.

There are several types of nevi, including:

* Common nevi: These are the most common type of mole and are usually small, round, and brown or black. They can be flat or raised and can appear anywhere on the body.
* Atypical nevi: These moles are larger than common nevi and have irregular borders and color. They may be flat or raised and can appear anywhere on the body, but are most commonly found on the trunk and extremities. Atypical nevi are more likely to develop into melanoma, a type of skin cancer, than common nevi.
* Congenital nevi: These moles are present at birth and can vary in size from small to large. They are more likely to develop into melanoma than moles that develop later in life.
* Spitz nevi: These are rare, benign growths that typically appear in children and adolescents. They are usually pink or red and dome-shaped.

It is important to monitor nevi for changes in size, shape, color, and texture, as these can be signs of melanoma. If you notice any changes in a mole, or if you have a new mole that is unusual or bleeding, it is important to see a healthcare provider for further evaluation.

A Nevus of Ota, also known as an oculodermal melanocytosis, is a benign birthmark characterized by the presence of darkly pigmented (melanin-containing) cells called melanocytes in the skin and mucous membranes around the eye. These pigmented cells can also extend to the sclera (the white part of the eye), dura mater (the outer covering of the brain), and leptomeninges (the middle layer of the meninges, which cover the brain and spinal cord).

The Nevus of Ota typically presents as a unilateral (occurring on one side) bluish-gray or brown patch that follows the distribution of the ophthalmic and maxillary divisions of the trigeminal nerve. It usually affects the eye, forehead, temple, and cheek, but it can also involve other areas of the face, scalp, and neck.

While Nevi of Ota are generally harmless, they may be associated with an increased risk of developing melanoma (a type of skin cancer) in the affected area. Therefore, regular monitoring and evaluation by a healthcare professional is recommended.

Dysplastic Nevus Syndrome, also known as atypical mole syndrome, is a condition characterized by the presence of numerous dysplastic nevi (abnormal moles) that may appear irregular in shape, color, and size. These moles are typically larger than normal moles (greater than 5 mm in diameter) and have an asymmetrical shape, uneven borders, and varied colors.

Individuals with Dysplastic Nevus Syndrome have a higher risk of developing melanoma, a type of skin cancer that can be life-threatening if not detected and treated early. The syndrome is usually inherited in an autosomal dominant manner, meaning that a child has a 50% chance of inheriting the gene from an affected parent.

It's important to note that having dysplastic nevi does not necessarily mean that a person will develop melanoma, but it does increase their risk. Regular skin examinations by a dermatologist and self-examinations are recommended for early detection of any changes in moles or the development of new suspicious lesions.

... "nevus sebaceus of Jadassohn": 773 ) is a congenital, hairless plaque that typically occurs on the face or scalp. Such nevi are ... Nevus sebaceus or sebaceous nevus (the first term is its Latin name, the second term is its name in English; also known as an " ... Rarely, sebaceous nevi can give rise to sebaceous carcinoma. However, the rate of such malignancies is now known to be less ... The condition is named for an overgrowth of sebaceous glands, a relatively uncommon hamartoma, in the area of the nevus. NSJ is ...
Nevus sebaceous was first identified in 1895 by Jadassohn. Sebaceous nevi occur in 1 to 3 of 1000 births, with equal incidence ... "sebaceous nevus syndrome", "Solomon syndrome", and "Jadassohn's nevus phakomatosis". "Nevus" is sometimes spelled "naevus" and ... There is no test to determine whether an individual born with a sebaceous nevus will go on to develop further symptoms of ... Lovejoy FH Jr, Boyle WE Jr (1973). "nevus sebaceous syndrome: Report of two cases and a review of the literature". Pediatrics. ...
... comedo nevus) Nevus comedonicus syndrome Nevus sebaceous (nevus sebaceous of Jadassohn, organoid nevus) Nevus unius lateris ... Blue nevus (blue neuronevus, dermal melanocytoma, nevus bleu) Blue nevus of Jadassohn-Tièche (common blue nevus, nevus ceruleus ... sebaceous epithelioma) Sebaceous adenoma Sebaceous carcinoma Sebaceous hyperplasia Sebaceous nevus syndrome Seboacanthoma ... atypical nevus, B-K mole, Clark's nevus, dysplastic melanocytic nevus, nevus with architectural disorder) Dysplastic nevus ...
Nevus Sebaceous of Jadassohn: yellow-orange flat plaque, occurring most commonly on the scalp (60%) or face (30%), usually ... Tièche-Jadassohn naevus: A hard, dark blue, benign melanocytic tumor. Jadassohn-Lewandowsky syndrome: An ectodermal dysplasia ... Dermatologie, (1938). Jadassohn-Lewandowsky syndrome Josef Jadassohn @ Who Named It Textbook of contact dermatitis by Richard J ... Joseph (Josef) Jadassohn (10 September 1863, Liegnitz - 24 March 1936, Zurich) was a German dermatologist. He was an assistant ...
... type B M8780/0 Blue nevus, NOS Jadassohn blue nevus M8780/3 blue nevus, malignant M8790/0 Cellular blue nevus M8800/0 Soft ... M8410/0 Sebaceous adenoma (C44._) M8410/3 Sebaceous adenocarcinoma (C44._) Sebaceous carcinoma M8413/3 Eccrine adenocarcinoma ( ... M8750/0 Intradermal nevus Dermal nevus M8760/0 compound nevus Dermal and epidermal nevus M8761/0 Small congenital nevus M8761/1 ... nevus M8770/0 Epithelioid and spindle cell nevus Juvenile nevus Juvenile melanoma Spitz nevus Pigmented spindle cell nevus of ...
Hidradenoma is a relatively rare benign tumor of sweat gland origin that can rarely arise within a nevus sebaceous. We present ... The predisposition to epithelial neoplasms in nevus sebaceous is well established; most tumors occur in adults and are benign. ... an interesting case of a hidradenoma and sebaceoma arising within a nevus sebaceous and present a literature review of the 2 ... Hidradenoma is a relatively rare benign tumor of sweat gland origin that can rarely arise within a nevus sebaceous. We present ...
... the component may be sebaceous, apocrine, eccrine, follicular, or keratinocytic. An estimated one third of individuals with ... Epidermal nevi (EN) are congenital hamartomas of embryonal ectodermal origin classified on the basis of their main component; ... epidermal nevi have involvement of other organ systems; hence, this condition is considered to... ... Linear sebaceous nevus (Jadassohn nevus phacomatosis). In 84% of patients with linear sebaceous nevus, skin lesions are on the ...
... the component may be sebaceous, apocrine, eccrine, follicular, or keratinocytic. An estimated one third of individuals with ... Epidermal nevi (EN) are congenital hamartomas of embryonal ectodermal origin classified on the basis of their main component; ... epidermal nevi have involvement of other organ systems; hence, this condition is considered to... ... Linear sebaceous nevus (Jadassohn nevus phacomatosis). In 84% of patients with linear sebaceous nevus, skin lesions are on the ...
... "nevus sebaceus of Jadassohn": 773 ) is a congenital, hairless plaque that typically occurs on the face or scalp. Such nevi are ... Nevus sebaceus or sebaceous nevus (the first term is its Latin name, the second term is its name in English; also known as an " ... Rarely, sebaceous nevi can give rise to sebaceous carcinoma. However, the rate of such malignancies is now known to be less ... The condition is named for an overgrowth of sebaceous glands, a relatively uncommon hamartoma, in the area of the nevus. NSJ is ...
Nevus Sebaceous of Jadassohn in the Newborn].. Meireles A; Pereira M; Costa MJ. Acta Med Port; 2020 Apr; 33(4):288. PubMed ID: ... 6. [SEBACEOUS NEVUS OF JADASSOHN].. DUY TN. Sem Hop; 1965 Jan; 41():95-9. PubMed ID: 14304538. [No Abstract] [Full Text] [ ... Nevus sebaceous of Jadassohn.. Baker BB; Imber RJ; Templer JW. Arch Otolaryngol; 1975 Aug; 101(8):515-6. PubMed ID: 1156245. [ ... 9. Sebaceous nevus of Jadassohn: review and clinical-surgical approach.. Neto MPDS; Assis BR; Andrade GR. An Bras Dermatol; ...
Nevus, Sebaceous of Jadassohn* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Beckers nevus onset in an adult man on the temporo-parietal-occipital region. Hua SR, Wen PF, Wang L. Hua SR, et al. Ital J ... Beckers nevus Krishna Prasanth Baalann et al. Pan Afr Med J. 2022. . ... Bilaterally Asymmetrical Beckers Nevus. Zainab Z, Malik NA, Obaid S, Mumtaz M, Aftab K, Malik S, Pervaiz A, Syed Z. Zainab Z, ...
This tumor is thought to arise from sebaceous glands in the skin and, thus, may arise anywhere on the body where these glands ... Sebaceous gland carcinoma is an aggressive, uncommon, cutaneous tumor first well-described by Allaire in 1891. ... Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol. 2007 ... Arshad AR, Azman WS, Kreetharan A. Solitary sebaceous nevus of Jadassohn complicated by squamous cell carcinoma and basal cell ...
Los nevus congénitos y adquiridos en los niños que pueden tener distintos tamaños y localizaciones. Deben controlarse y evaluar ... Sebaceous or Jadassohn nevus It is generally orange or yellowish in color and can be verrucous or with excrescences. It can ... Epidermal Nevus Epidermal nevi can present in the context of a syndrome, so they require multidisciplinary evaluation, with a ... Congenital melanocytic nevi They are birthmarks that can have different sizes and shapes. This nevus are associated with ...
Nevus Sebaceous of Jadassohn. Nevus, Sebaceous of Jadassohn. Pagets Disease, Extramammary. Paget Disease Extramammary. ...
206 Sebaceous tumors Shawl sign, 409 liposarcoma, 178, 207 nevus sebaceus of Jadassohn, 201, 201f Shingles (zoster), 70, 70f, ... Histologically, iris nevus appears as a followed with meticulous medical documentation. Online theres uncertainty over the use ... See additionally 315f Sebaceous trichofolliculoma, 199 Tuberous sclerosis leiomyosarcoma, ... 290f sebaceous carcinoma, 201-202 Side effects, drug, 324t-329t. GranuFoam Silver y la superfcie de la herida; sin embargo, ...
Jadassohn Nevus Phakomatosis Linear Sebaceous Nevus Syndrome Linear Verrucous Epidermal Nevus Nevus Sebaceus of Jadassohn Nevus ... Sebaceous Nevus Syndrome, Linear Sebaceous Nevus of Jadassohn Verrucous Epidermal Nevus Verrucous Nevus Previous Indexing. ... Nevus or specifics (1967-2007). Public MeSH Note. 2010; see NEVUS SEBACEOUS OF JADASSOHN 2008-2009. History Note. 2010 (2008). ... Nevus, Sebaceous of Jadassohn Preferred Term Term UI T723726. Date08/08/2008. LexicalTag EPO. ThesaurusID NLM (2010). ...
Jadassohn Nevus Phakomatosis Linear Sebaceous Nevus Syndrome Linear Verrucous Epidermal Nevus Nevus Sebaceus of Jadassohn Nevus ... Sebaceous Nevus Syndrome, Linear Sebaceous Nevus of Jadassohn Verrucous Epidermal Nevus Verrucous Nevus Previous Indexing. ... Nevus or specifics (1967-2007). Public MeSH Note. 2010; see NEVUS SEBACEOUS OF JADASSOHN 2008-2009. History Note. 2010 (2008). ... Nevus, Sebaceous of Jadassohn Preferred Term Term UI T723726. Date08/08/2008. LexicalTag EPO. ThesaurusID NLM (2010). ...
Nevus Sebaceous of Jadassohn. Nevus, Sebaceous of Jadassohn. Pagets Disease, Extramammary. Paget Disease Extramammary. ...
Nevus Sebaceous of Jadassohn. Nevus, Sebaceous of Jadassohn. Pagets Disease, Extramammary. Paget Disease Extramammary. ...
Nevus Sebaceous of Jadassohn. Nevus, Sebaceous of Jadassohn. Pagets Disease, Extramammary. Paget Disease Extramammary. ...
The upper dermis showed underdeveloped hair follicles with sebaceous glands, consistent with sebaceous nevus. There were no ... Following a diagnosis of cerebriform nevus sebaceous, complete excision was performed with excellent aesthetic results. ... Da Cunha Filho, R. R., Fezer, A. P., & Lorencette, N. A. (2015). Nevus sebáceo cerebriforme: Uma rara apresentação. Anais ...
MCs mimicking sebaceous nevus of Jadassohn, ecthyma, and giant condylomata acuminata have been reported. ... Itin PH, Gilli L. Molluscum contagiosum mimicking sebaceous nevus of Jadassohn, ecthyma and giant condylomata acuminata in HIV- ...
Tumours of sebaceous gland were 7 (13.5); they comprised mainly Nevus sebaceous of Jadassohn (6); composed of immature ... sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma. Tumours of hair follicle were 4 (7.7) ...
Basal cell carcinoma associated with nevus sebaceous of Jadassohn. *Basosquamous carcinoma is a rare aggressive epithelial ...
Nevus, Sebaceous of Jadassohn. *Oculocerebrorenal Syndrome. *Orofaciodigital Syndromes. *Pallister-Hall Syndrome. *Pentalogy of ...
MCs mimicking sebaceous nevus of Jadassohn, ecthyma, and giant condylomata acuminata have been reported. ... Itin PH, Gilli L. Molluscum contagiosum mimicking sebaceous nevus of Jadassohn, ecthyma and giant condylomata acuminata in HIV- ...
... the component may be sebaceous, apocrine, eccrine, follicular, or keratinocytic. An estimated one third of individuals with ... Epidermal nevi (EN) are congenital hamartomas of embryonal ectodermal origin classified on the basis of their main component; ... epidermal nevi have involvement of other organ systems; hence, this condition is considered to... ... epidermal nevus syndrome, Solomon syndrome, linear sebaceous nevus (LSN) syndrome, organoid nevus phacomatosis, or Jadassohn ...
Organoid Nevus Phakomatosis use Nevus, Sebaceous of Jadassohn Organoids Organomercury Compounds Organometallic Compounds ...
Sebaceous nevus Current Synonym true false 3028752014 Nevus sebaceous of Jadassohn Current Synonym true false ... Sebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid, pigmented nevus syndrome ( ... Nevus sebaceous (disorder) {707136009 , SNOMED-CT } Parent/Child (Relationship Type) Didymosis aplasticosebacea (disorder) { ... Organoid nevus Current Synonym true false 3028702017 Naevus sebaceous of Jadassohn Current Synonym true false ...
Usually it is presented at birth or in early childhood as an isolated lesion associated with nevus sebaceous of Jadassohn. ... In 5 patients, an SCAP was developed from a sebaceous nevus and in 6 it developed de novo. The total sample developed SCAP ... The main differential diagnoses were the nevo sebaceous, warty nevus and wart. Conclusions: This study is the first SCAP case ... Both the patients with solitary SCAP, and those associated with nevo sebaceous, presented similar clinical signs with an ...
Blue Nevus, Epithelioid and Spindle Cell Nevus, Halo Nevus, Intradermal Nevus, Pigmented Nevus, Sebaceous of Jadassohn Nevus, ... Neutrophil Activation Neutrophil Infiltration Neutrophils Nevada Nevi and Melanomas Nevirapine Nevus Nevus of Ota Nevus, ... Seasonal Affective Disorder Seasons Seat Belts Seawater Seaweed Sebaceous Gland Diseases Sebaceous Gland Neoplasms Sebaceous ... Sebaceous Adenofibroma Adenoidectomy Adenoids Adenolymphoma Adenoma Adenoma, Acidophil Adenoma, Basophil Adenoma, Bile Duct ...
... linear sebaceous nevus sequence, sebaceous nevus syndrome and Jadassohn sebaceous nevus syndrome. ... This type of ENS is characterized by the presence of a sebaceous nevus and a condition known as speckled lentiginous nevus of ... For a description of sebaceous nevus see Schimmelpenning syndrome above.) Speckled lentiginous nevus is characterized by large ... While sebaceous nevus is present at birth, the characteristic Papules of speckled lentiginous nevus may not develop until later ...
Nevus Sebaceous of Jadassohn. Nevo Sebáceo de Jadassohn. Nevo Sebáceo de Jadassohn. ...
Nevus, Pigmented. *Nevus, Sebaceous of Jadassohn. Below are MeSH descriptors whose meaning is more specific than "Nevus, Halo". ... "Nevus, Halo" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Nevus, Halo" by people in this website by year, and whether " ... Below are the most recent publications written about "Nevus, Halo" by people in Profiles. ...
  • Usually, no symptoms of the nevi are present, with the exception of inflammatory linear verrucous epidermal nevus. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is a linear, persistent, pruritic plaque, usually first noted on a limb in early childhood. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus, unlike the other types of epidermal nevi, demonstrates erythema and sometimes pruritus. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus is characterized by tiny, discrete, erythematous, slightly warty papules, which tend to coalesce in a linear formation. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus may occur with musculoskeletal abnormalities in a few children, prompting the classification of inflammatory linear verrucous epidermal nevus as part of epidermal nevus syndrome. (medscape.com)
  • One infant had inflammatory linear verrucous epidermal nevus with congenital dislocation of the ipsilateral hip and Fallot tetralogy of the heart. (medscape.com)
  • Another infant had congenital inflammatory linear verrucous epidermal nevus with congenital bony anomalies of the ipsilateral extremities. (medscape.com)
  • Nevus depigmentosus and inflammatory linear verrucous epidermal nevus may occur together, as may inflammatory linear verrucous epidermal nevus and melanodontia. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus (ILVEN) on the trunk. (mhmedical.com)
  • These include linear sebaceous nevus, linear nevus comedonicus (NC), linear epidermal nevus (LEN), and inflammatory linear verrucous epidermal nevus (ILVEN). (medscape.com)
  • [ 3 ] delineated inflammatory linear verrucous epidermal nevus as a distinct entity in 25 patients. (medscape.com)
  • They coined the name inflammatory linear verrucous epidermal nevus, labeling it a clinical and histopathologic type of linear verrucous nevus that is often inflammatory or psoriasiform. (medscape.com)
  • Inflammatory linear verrucous epidermal nevus accounts for approximately 5% of patients with epidermal nevi and has been described in a mother and daughter. (medscape.com)
  • hence, this condition is considered to be an epidermal nevus syndrome (ENS). (medscape.com)
  • Solomon defines epidermal nevus syndrome as a sporadic neurocutaneous linkage of congenital ectodermal defects in the skin, brain, eyes, and/or skeleton. (medscape.com)
  • Epidermal nevus syndrome is often termed the Solomon syndrome. (medscape.com)
  • 1,2) Larger lesions in a Blaschkoid distribution are observed in the epidermal nevus syndrome known as the Schimmelpenning-Feuerstein-Mims syndrome (SFM), associated with extracutaneous abnormalities of the eyes (strabismus, colobomas, lipodermoids), central nervous system (structural brain abnormalities, seizures), and skeleton (craniofacial, limb deformities). (aad.org)
  • Figure 145-3 ) can be part of an epidermal nevus syndrome but some affected persons only have the cutaneous EN. (mhmedical.com)
  • A clinical entity called epidermal nevus syndrome should be more precisely defined and distinguished by clinical, histopathologic, and genetic criteria. (medscape.com)
  • Linear epidermal nevus syndrome is a congenital neurocutaneous disorder characterized by linear epidermal nevus with significant involvement of the nervous, ophthalmologic, and/or skeletal systems. (medscape.com)
  • The condition is named for an overgrowth of sebaceous glands, a relatively uncommon hamartoma, in the area of the nevus. (wikipedia.org)
  • In 1895, Jadassohn first described nevus sebaceus (see the image below), a circumscribed hamartomatous lesion predominantly composed of sebaceous glands. (medscape.com)
  • It is a benign congenital hamartoma related to abnormalities of the epidermis, sebaceous glands, sweat glands, and hair follicles. (aad.org)
  • The upper dermis showed underdeveloped hair follicles with sebaceous glands, consistent with sebaceous nevus. (mendeley.com)
  • Nevus sebaceous (NS) is a hamartoma of the epidermis, hair follicles, and sebaceous and apocrine glands. (mhmedical.com)
  • They are present at birth, devoid of normal hair follicles and can change at puberty, becoming thicker and greasy, when the sebaceous glands begin to proliferate. (lahairmd.com)
  • Microscopy showed dilated, keratin filled infundibulum surrounded by numerous mature and immature sebaceous glands. (ijcrr.com)
  • It is defined by hyperplasia of the epidermis, hair follicles, sebaceous and apocrine glands. (ijcrr.com)
  • Sebaceous nevi and verrucous epidermal nevi are closely related, and many authors regard them as variants. (medscape.com)
  • NS become more prominent during puberty, reflecting sebaceous growth, often becoming verrucous. (aad.org)
  • In another review of 131 cases of EN, most (60%) had noninflammatory EN, 1/3 had NS, and 6 percent had inflammatory linear verrucous EN. (mhmedical.com)
  • Congenital sebaceous nevus, also called, nevus sebaceous of Jadassohn is a congenital sebaceous gland hamartoma. (lahairmd.com)
  • Nevus sebaceous is a benign, congenital hamartoma of the skin, with a predilection for the scalp and less commonly occurs on the face, around the ears, neck or on the trunk. (ijcrr.com)
  • DISCUSSION Nevus sebaceous is a congenital hamartoma of the skin, first described by Jadassohn. (ijcrr.com)
  • Rarely, malignant eccrine poromas, sebaceous carcinomas, and apocrine carcinomas have been reported to result in widespread metastases and death. (medscape.com)
  • Epidermal nevi (EN) are congenital hamartomas of ectodermal origin classified on the basis of their main component: sebaceous, apocrine, eccrine, follicular, or keratinocytic. (mhmedical.com)
  • 4] Syringocystadenoma papilliferum, formerly known as nevus syringocystadenomatous papilliferus, is a proliferating tumor with mostly apocrine differentiation but eccrine differentiation can also be seen. (ijcrr.com)
  • Skin growths such as benign tumors and basal cell carcinoma can arise in sebaceous nevi, usually after puberty. (wikipedia.org)
  • Rarely, sebaceous nevi can give rise to sebaceous carcinoma. (wikipedia.org)
  • Deletions of the patched gene have been identified in nevus sebaceus and may be responsible for the predisposition to the development of basal cell carcinoma and other tumors in this lesion. (medscape.com)
  • Other benign and malignant tumors include apocrine cystadenoma , leiomyoma and sebaceous cell carcinoma. (medscape.com)
  • Rarely, other malignancies such as sebaceous carcinoma, microcystic adnexal carcinoma, and melanoma may complicate NS. (aad.org)
  • Sebaceous carcinoma is an outright malignant neoplasm with prominent cellular pleomorphism and anaplasia. (medscape.com)
  • Well-differentiated sebocytes in small nests, deeply infiltrating the subcutaneous tissue, thus consistent with sebaceous carcinoma. (medscape.com)
  • Sebaceous carcinomas are common on the eyelid and tend to present with pagetoid extension of atypical sebaceous cells in the conjunctiva or in the epidermis. (medscape.com)
  • also known as an "organoid nevus": 661 and "nevus sebaceus of Jadassohn": 773 ) is a congenital, hairless plaque that typically occurs on the face or scalp. (wikipedia.org)
  • Nevus sebaceous is a rare benign tumor in children that usually presents with warty patches of hair loss on the scalp. (medscape.com)
  • In 84% of patients with linear sebaceous nevus, skin lesions are on the face, and in approximately 50%, lesions are on the scalp, the neck, and the forehead. (medscape.com)
  • Nevus sebaceous on the scalp of a 14-year-old boy. (mhmedical.com)
  • These sebaceous nevi can involve the scalp and face. (lahairmd.com)
  • In some children, seizures are drug resistant and may result in progressive mental retardation, which is noted in approximately 70% of patients with Jadassohn nevus phacomatosis. (medscape.com)
  • Phacomatosis pigmentokeratotica is characterized by the presence of multiple organoid nevi with sebaceous differentiation, a speckled lentiginous nevus, and skeletal and neurologic abnormalities. (medscape.com)
  • NSJ is first described by Josef Jadassohn in 1895. (wikipedia.org)
  • First described by Jadassohn in 1895, nevus sebaceus (NS) is a common lesion, affecting 0.3% of newborns. (aad.org)
  • The term organoid nevus may be used to emphasize the admixture of epidermal cells often evident in individual lesions of epidermal nevi. (medscape.com)
  • Dermoscopy and confocal microscopy may be helpful in the clinical diagnosis of sebaceous lesions. (medscape.com)
  • Immunohistochemistry may be helpful in the differential diagnosis between benign and malignant sebaceous lesions. (medscape.com)
  • In most patients, the lesions appear on 1 side of the body (nevus unius lateralis), as shown in the images below. (medscape.com)
  • Nevi (moles) and other melanocytic lesions are dealt with in the article melanocytic lesions . (librepathology.org)
  • [ 1 ] In 1957, he described a case of sebaceous nevus involving the head, with ipsilateral ocular lesions including coloboma of the upper lid, increased density of cranial bones, epileptic seizures, and mental retardation. (medscape.com)
  • Should nevus sebaceus of Jadassohn in children be excised? (wikipedia.org)
  • Nevus sebaceus manifesting as a bald patch in a child. (medscape.com)
  • In nevus sebaceus, postzygotic somatic mutations may result in various clinical expressions of mosaicism. (medscape.com)
  • Nevus sebaceus appears to respond to hormonal influences, as the lesion can be raised at birth, become flattened in childhood, and become raised again during puberty. (medscape.com)
  • Nevus sebaceus occurs with equal frequency in males and females of all races. (medscape.com)
  • Of newborns, 0.3% are affected by nevus sebaceus. (medscape.com)
  • Males and females are equally affected by nevus sebaceus. (medscape.com)
  • Nevus sebaceus is usually noted as a solitary lesion at birth or in early childhood, whereas the characteristic features may not develop until puberty. (medscape.com)
  • The medical importance of a solitary nevus sebaceus relates to the description of both benign change and, in some cases, malignant neoplastic change. (medscape.com)
  • The most frequent benign tumors are trichoblastomas and syringocystadenoma papilliferum, occurring in less than 5% of nevus sebaceus. (medscape.com)
  • The development of secondary malignant neoplasms within the nevus sebaceus is rare and occurs almost exclusively in adults. (medscape.com)
  • The aphorism in medical education that half of what you learn in medical school will prove to be wrong could use the nevus sebaceus (sebaceous) of Jadassohn as its poster child. (aad.org)
  • The authors concluded: "Our study confirms that most of the secondary neoplasms arising in association with nevus sebaceus are benign. (aad.org)
  • It has also been called Schimmelpenning-Feuerstein-Mims syndrome and Jadassohn nevus phakomatosis. (medscape.com)
  • Post-zygotic mutations in FGFR2 have also been identified in mosaic forms of acne, keratinocytic epidermal nevi, nevoid acanthosis nigricans/rounded and velvety epidermal nevus (RAVEN). (aad.org)
  • Sebaceous epithelioma (also known as sebaceoma) differs from sebaceous adenoma mainly in regards to the degree of differentiation. (medscape.com)
  • Adipophilin and periplipin are two such antigens associated with sebaceous differentiation. (medscape.com)
  • Nevus comedonicus syndrome has ocular, skeletal, and central nervous system anomalies. (medscape.com)
  • There is a major problem with the latter method in that mutations are seen in sebaceous tumors in patients without the syndrome. (medscape.com)
  • EN syndrome is also called Solomon syndrome and is a neurocutaneous disorder characterized by EN and an assortment of neurologic and visceral manifestations. (mhmedical.com)
  • Linear sebaceous nevus, also known as organoid nevus syndrome, often has the term linear deleted because almost all syndromic sebaceous nevi are linear. (medscape.com)
  • Schimmelpenning syndrome, as noted above, links a sebaceous nevus with cerebral anomalies, coloboma, and lipodermoid of the conjunctiva. (medscape.com)
  • Cataracts may be a prominent feature of nevus comedonicus syndrome. (medscape.com)
  • Nevus sebaceous syndrome (NSS) is a rare, multisystem neurocutaneous disorder, characterized by a congenital nevus, and may include brain malformations such as hemimegalencephaly or focal cortical dysplasia, ocular, and skeletal features. (bvsalud.org)
  • Nevus comedonicus is evident clinically as confluent clusters of dilated follicular orifices plugged with keratin, giving the appearance of aggregated open comedones. (medscape.com)
  • Characteristic epidermal nevus in the axillary fossa of a child with Jadassohn nevus phakomatosis. (medscape.com)
  • A case of syringocystadenoma papilliferum associated with nevus sebaceous in a 26 year old female patient in the nipple areolar region. (ijcrr.com)
  • A rare site of occurance of syringocystadenoma papilliferum arising in nevus sebaceous is described. (ijcrr.com)
  • Syringocystadenoma papilliferum is a benign adnexal tumor of the skin,[2] which can occur either de novo or on some organoid nevus such as nevus sebaceous. (ijcrr.com)
  • These classical histological features favored a diagnosis of Syringocystadenoma Papilliferum associated with Nevus Sebaceous. (ijcrr.com)
  • Nevus sebaceous often presents at birth, is quiescent in childhood and grows during puberty, probably due to increased levels of serum androgens present in neonatal period and at puberty. (ijcrr.com)
  • Sebaceous nevi are sporadic and occur with equal frequency in males and females of all races. (medscape.com)
  • EN are uncommon (approximately 1 to 3 percent of newborns and children), sporadic, and usually present at birth, although they can appear in early childhood. (mhmedical.com)
  • The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi. (sdsu.edu)
  • The clinical presentation of nevus sebaceous and syringocystadenoma papilleferum varies widely but the histological appearance is uniform and characteristic, forming the basis of diagnosis. (ijcrr.com)
  • [ 32 ] Also helpful may be demonstration of lipid contents in the vacuoles of the sebaceous cells in less differentiated carcinomas. (medscape.com)
  • Following a diagnosis of cerebriform nevus sebaceous, complete excision was performed with excellent aesthetic results. (mendeley.com)
  • Lobules contain basaloid cells at the periphery and mature sebaceous cells, with characteristic cytoplasmic vacuoles toward the center. (medscape.com)
  • Histologic section of sebaceous adenoma showing a predominance of sebaceous cells with prominent cytoplasmic vacuoles. (medscape.com)
  • INTRODUCTION Nevus sebaceous is a congenital skin lesion commonly seen by pediatricians, dermatologists, and plastic surgeons. (ijcrr.com)
  • Confocal microscopy revealed sebaceous lobules composed by clusters of ovoid cells with dark nuclei and bright, highly refractile glistening cytoplasm. (medscape.com)
  • Seizures are reported in 75% of patients with linear sebaceous nevus, mostly appearing in the first 6 months of life. (medscape.com)
  • As with other epidermal nevi, the most common sites are the face, the trunk, and proximal extremities. (medscape.com)
  • Such nevi are classified as epidermal nevi and can be present at birth, or early childhood, and affect males and females of all races equally. (wikipedia.org)
  • thus if any change is seen within the nevus sebaceous, the patients should seek medical advice. (medscape.com)
  • Likewise, a high proportion of sebaceous adenomas demonstrate loss of MSH-2 or MLH-1 , but very few of these patients will have MTS. (medscape.com)
  • in one study, 7.9 percent of patients with EN had one of the nine syndromes-an estimated one per 11,928 pediatric patients. (mhmedical.com)
  • Sebaceous epithelioma lacks the lobular architecture and sebaceous maturation of sebaceous adenoma, and contains an obvious preponderance of undifferentiated cells. (medscape.com)
  • Histologic section of sebaceous epithelioma showing a predominance of basaloid cells. (medscape.com)