An abnormal hardening or increased density of bone tissue.
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)
A scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Excision of one or more of the parathyroid glands.
Tumors or cancer of the PARATHYROID GLANDS.

Erdheim-Chester disease: a case report. (1/101)

A 42-year-old man with Erdheim-Chester disease (EC) is presented. This is the first case of this disease reported in Korea. The patient complained of knee pain and plain roentgenogram of the bilateral legs revealed diffusely increased density, coarsened trabecular pattern, and cortical thickening in the diaphysis, and metaphysis as well as epiphysis. Magnetic resonance imaging revealed that the lesions showed low signal intensity on T1-weighted images and heterogeneously low and high signal intensity on T2-weighted images. Histological examination of the biopsy specimen showed a xanthogranulomatous lesion consisting aggregations of foamy histiocytes and Touton-type giant cells. Immunohistochemical staining showed positive reaction to anti-S-100 and lysozyme in the cytoplasm of the giant cells.  (+info)

Onset and dynamics of osteosclerosis in mice induced by Reilly-Finkel-Biskis (RFB) murine leukemia virus. Increase in bone mass precedes lymphomagenesis. (2/101)

Newborn NMRI strain mice were infected with Reilly-Finkel-Biskis (RFB) murine leukemia virus (MuLV), a murine leukemia virus that has been shown to induce lymphomas, osteosclerosis, and osteomas in susceptible strains of mice. Bone histomorphometry of the distal femoral metaphyses at 3-month intervals showed osteosclerosis 3 (100%), 6 (100%), and 9 (93%) months after infection. This was represented by significantly augmented cancellous bone mass and accompanied by distinct changes in bone architecture. High numbers of provirus copies were detected at 2-4 weeks in femora, humeri, and calvaria, and viral protein was highly expressed in trabecular and cortical bone cells, particularly in osteocytes. Infected mice showed enhanced bone formation and smaller numbers of osteoclasts relative to sex- and age-matched controls. Osteoclastic differentiation was significantly reduced in cocultures of spleen or bone marrow cells with RFB MuLV-infected osteoclastogenic, osteoblast-like cells. However, RFB MuLV did not impair the activity of mature osteoclasts. In infected mice lymphomas were only observed at 6 (22%) and 9 months (40%) of age. At 3 months, IgG gene and TCR-beta gene rearrangements were not detectable, and new proviruses showed a heterogeneous integration pattern, indicating the absence of lymphoma in early osteosclerotic mice. In contrast, lymphomas, which developed in 8- to 9-month-old infected mice, showed IgG rearrangements indicating development of B-cell lymphomas, together with mono- or oligoclonal expansion of distinct patterns of proviral integrations. These results indicate that RFB MuLV-induced osteosclerosis develops within 3 months after infection and precedes lymphomagenesis. It may therefore be considered an independent skeletal lesion in MuLV-infected mice.  (+info)

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. (3/101)

Osteoclasts express the alphavbeta3 integrin, an adhesion receptor that has been implicated in bone resorption and that is therefore a potential therapeutic target. To assess the role of this heterodimer in skeletal development in vivo, we engineered mice in which the gene for the beta3 integrin subunit was deleted. Bone marrow macrophages derived from these mutants differentiate in vitro into numerous osteoclasts, thus establishing that alphavbeta3 is not necessary for osteoclast recruitment. Furthermore, the closely related integrin, alphavbeta5, does not substitute for alphavbeta3 during cytokine stimulation or authentic osteoclastogenesis. beta3 knockout mice, but not their heterozygous littermates, develop histologically and radiographically evident osteosclerosis with age. Despite their increased bone mass, beta3-null mice contain 3.5-fold more osteoclasts than do heterozygotes. These mutant osteoclasts are, however, dysfunctional, as evidenced by their reduced ability to resorb whale dentin in vitro and the significant hypocalcemia seen in the knockout mice. The resorptive defect in beta3-deficient osteoclasts may reflect absence of matrix-derived intracellular signals, since their cytoskeleton is distinctly abnormal and they fail to spread in vitro, to form actin rings ex vivo, or to form normal ruffled membranes in vivo. Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function.  (+info)

Terminal phalageal osteosclerosis. (4/101)

Osteosclerosis of the terminal finger phalanges was assessed by means of a grading score in two age-matched groups of 96 females, each suffering from rheumatoid arthritis (RA) and osteoarthrosis (OA), respectively, and in a sample of 894 males and females, above the age of 44 years, from Dutch small town populations. Cortical thickness of the therminal phalanges decreases markedly with age. Whereas in the age group 45-54 years, terminal phalangeal osteosclerosis is more pronounced in females, at higher ages the difference between the sexes disappears. The diameter of the terminal cortex increases gradually from the second to the fifth finger. No differences were found between the RA and the OA groups, nor were these groups different from the population survey except for a lower incidence of terminal phalangeal osteosclerosis in female osteoarthrotics between 45 and 55 years of age, compared to females of the same age group from the population sample.  (+info)

MR imaging of medullary streaks in osteosclerosis: a case report. (5/101)

We present a case of medullary sclerosis of the appendicular skeleton in a patient with chronic renal insufficiency for whom MR imaging findings were characteristic. T1- and T2-weighted MR images showed multiple vertical lines (medullary streaks) of low signal intensity in the metaphyses and diaphyses of the distal femur and proximal tibia.  (+info)

Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. (6/101)

The TGF-betas are multifunctional proteins whose activities are believed to be controlled by interaction with the latent TGF-beta binding proteins (LTBPs). In spite of substantial effort, the precise in vivo significance of this interaction remains unknown. To examine the role of the Ltbp-3, we made an Ltbp-3-null mutation in the mouse by gene targeting. Homozygous mutant animals develop cranio-facial malformations by day 10. At 2 mo, there is a pronounced rounding of the cranial vault, extension of the mandible beyond the maxilla, and kyphosis. Histological examination of the skulls from null animals revealed ossification of the synchondroses within 2 wk of birth, in contrast to the wild-type synchondroses, which never ossify. Between 6 and 9 mo of age, mutant animals also develop osteosclerosis and osteoarthritis. The pathological changes of the Ltbp-3-null mice are consistent with perturbed TGF-beta signaling in the skull and long bones. These observations give support to the notion that LTBP-3 is important for the control of TGF-beta action. Moreover, the results provide the first in vivo indication for a role of LTBP in modulating TGF-beta bioavailability.  (+info)

Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO. (7/101)

Myelofibrosis and osteosclerosis are prominent features arising in mice overexpressing thrombopoietin (TPO). The pivotal role of transforming growth factor beta 1 (TGF-beta 1) in the pathogenesis of myelofibrosis has been documented, but the mechanisms mediating osteosclerosis remain unclear. Here, we used mice deficient in osteoprotegerin (OPG), a secreted inhibitor of bone resorption, to determine whether osteosclerosis occurs through a deregulation of osteoclastogenesis. Marrow cells from opg-deficient mice (opg(-/-)) or wild-type (WT) littermates were infected with a retrovirus encoding TPO and engrafted into an opg(-/-) or WT background for long-term reconstitution. The 4 combinations of graft/host (WT/WT, opg(-/-)/opg(-/-), opg(-/-)/WT, and WT/opg(-/-)) were studied. Elevation of TPO and TGF-beta 1 levels in plasma was similar in the 4 experimental groups and all the mice developed a similar myeloproliferative syndrome associated with severe myelofibrosis. Osteosclerosis developed in WT hosts engrafted with WT or opg(-/-) hematopoietic cells and was associated with increased OPG levels in plasma and decreased osteoclastogenesis. In contrast, opg(-/-) hosts exhibited an osteoporotic phenotype and a growth of bone trabeculae was rarely seen. These findings suggest that osteosclerosis in mice with TPO overexpression occurs predominantly via an up-regulation of OPG in host stromal cells leading to disruption of osteoclastogenesis.  (+info)

Decrease of osteosclerosis in subchondral bone of medial compartmental osteoarthritic knee seven to nineteen years after high tibial valgus osteotomy. (8/101)

Osteosclerosis of the subchondral bone was measured by densitometer on plain radiographs in 55 medial compartmental osteoarthritic knees of 40 patients who were treated with high tibial valgus osteotomy for correction of varus deformity. The ratio of the osteosclerosis value of the medial side of the knee to that of the lateral side (Medial/Lateral ratio) was calculated and used as a parameter. The Medial/Lateral ratio of osteosclerosis decreased rapidly within three years after osteotomy at the reference points of the femur and the tibia. Even 7 to 19 years after osteotomy, a decrease of the ratio was noted in 16 knees with a standing femorotibial angle (FTA) less than 168 degrees (12 degrees of anatomical valgus angulation). This was interpreted to mean that osteosclerosis of the medial condyle decreased compared with that of the lateral condyle after overcorrection of varus deformity. In the cases of more than 7 years after high tibial osteotomy, a positive straight regression line was drawn by calculation between Medial/Lateral ratio and postoperative limb alignment expressed by standing femorotibial angle, with coefficient of correlation (gamma) of 0.295 (p < 0.01).  (+info)

Osteosclerosis is a medical term that refers to an abnormal thickening and increased density of bone tissue. This condition can occur as a result of various diseases or conditions, such as certain types of bone cancer, Paget's disease of bone, fluoride poisoning, or chronic infection of the bone. Osteosclerosis can also be seen in some benign conditions, such as osteopetrosis, which is a rare genetic disorder characterized by an excessively hard and dense skeleton.

In some cases, osteosclerosis may not cause any symptoms and may only be discovered on X-rays or other imaging studies. However, in other cases, it can lead to complications such as bone pain, fractures, or deformities. Treatment for osteosclerosis depends on the underlying cause of the condition and may include medications, surgery, or other therapies.

Osteopetrosis, also known as Albers-Schönberg disease or marble bone disease, is a group of rare genetic disorders characterized by increased bone density due to impaired bone resorption by osteoclasts. This results in brittle bones that are more susceptible to fractures and can also lead to various complications such as anemia, hearing loss, and vision problems. There are several types of osteopetrosis, which vary in severity and age of onset.

The medical definition of osteopetrosis is:

A genetic disorder characterized by defective bone resorption due to impaired osteoclast function, resulting in increased bone density, susceptibility to fractures, and potential complications such as anemia, hearing loss, and vision problems.

Primary myelofibrosis (PMF) is a rare, chronic bone marrow disorder characterized by the replacement of normal bone marrow tissue with fibrous scar tissue, leading to impaired production of blood cells. This results in cytopenias (anemia, leukopenia, thrombocytopenia), which can cause fatigue, infection susceptibility, and bleeding tendencies. Additionally, PMF is often accompanied by the proliferation of abnormal megakaryocytes (large, atypical bone marrow cells that produce platelets) and extramedullary hematopoiesis (blood cell formation outside the bone marrow, typically in the spleen and liver).

PMF is a type of myeloproliferative neoplasm (MPN), which is a group of clonal stem cell disorders characterized by excessive proliferation of one or more types of blood cells. PMF can present with various symptoms such as fatigue, weight loss, night sweats, abdominal discomfort due to splenomegaly (enlarged spleen), and bone pain. In some cases, PMF may progress to acute myeloid leukemia (AML).

The exact cause of PMF remains unclear; however, genetic mutations are known to play a significant role in its development. The Janus kinase 2 (JAK2), calreticulin (CALR), and MPL genes have been identified as commonly mutated in PMF patients. These genetic alterations contribute to the dysregulated production of blood cells and the activation of signaling pathways that promote fibrosis.

Diagnosis of PMF typically involves a combination of clinical evaluation, complete blood count (CBC), bone marrow aspiration and biopsy, cytogenetic analysis, and molecular testing to identify genetic mutations. Treatment options depend on the individual patient's symptoms, risk stratification, and disease progression. They may include observation, supportive care, medications to manage symptoms and control the disease (such as JAK inhibitors), and stem cell transplantation for eligible patients.

Congenital cortical hyperostosis is a rare, inherited bone disorder that is characterized by abnormal thickening of the outer layer of bones (cortical hyperostosis). This condition primarily affects the skull and long bones of the arms and legs. The exact cause of congenital cortical hyperostosis is not fully understood, but it is believed to be related to mutations in certain genes that regulate bone growth and development.

The symptoms of congenital cortical hyperostosis can vary widely from person to person, depending on the severity and location of the bone abnormalities. Some common features of this condition include:

* A thickened skull, which may cause a prominent forehead or a misshapen head
* Abnormally thick and dense long bones in the arms and legs, which can make them heavy and difficult to move
* Delayed growth and development
* Increased risk of fractures
* Pain and stiffness in the affected bones

Congenital cortical hyperostosis is typically diagnosed based on a combination of clinical symptoms, imaging studies (such as X-rays or CT scans), and genetic testing. There is no cure for this condition, but treatment may involve pain management, physical therapy, and surgery to correct any bone deformities. In some cases, the symptoms of congenital cortical hyperostosis may improve over time, but in others, they may persist throughout life.

Reticulin is a type of protein fiber that forms part of the extracellular matrix in various connective tissues in the body. It is composed of collagenous and non-collagenous proteins, and it has a reticular or network-like structure when viewed under a microscope. In histology (the study of the microscopic structure of tissues), reticulin fibers are often stained to help identify certain types of cells or structures.

In particular, reticulin fibers are often found in close association with certain types of cells, such as hematopoietic stem cells and neurons. They provide structural support and help regulate the function of these cells. In addition, reticulin fibers play a role in the immune response, wound healing, and tissue repair.

Abnormal accumulations of reticulin fibers can be seen in various disease states, such as fibrosis (excessive scarring) and certain types of cancer. For example, increased reticulin fibers are often found in the liver in patients with cirrhosis, a condition characterized by extensive scarring and damage to the liver. Similarly, abnormal reticulin fiber deposition is seen in some forms of lymphoma, a type of cancer that affects the lymphatic system.

"Bone" is the hard, dense connective tissue that makes up the skeleton of vertebrate animals. It provides support and protection for the body's internal organs, and serves as a attachment site for muscles, tendons, and ligaments. Bone is composed of cells called osteoblasts and osteoclasts, which are responsible for bone formation and resorption, respectively, and an extracellular matrix made up of collagen fibers and mineral crystals.

Bones can be classified into two main types: compact bone and spongy bone. Compact bone is dense and hard, and makes up the outer layer of all bones and the shafts of long bones. Spongy bone is less dense and contains large spaces, and makes up the ends of long bones and the interior of flat and irregular bones.

The human body has 206 bones in total. They can be further classified into five categories based on their shape: long bones, short bones, flat bones, irregular bones, and sesamoid bones.

Thrombopoietin (TPO) is a glycoprotein hormone that plays a crucial role in the regulation of platelet production, also known as thrombopoiesis. It is primarily produced by the liver and to some extent by megakaryocytes, which are the cells responsible for producing platelets.

TPO binds to its receptor, c-Mpl, on the surface of megakaryocytes and their precursor cells, stimulating their proliferation, differentiation, and maturation into platelets. By regulating the number of platelets in circulation, TPO helps maintain hemostasis, the process that prevents excessive bleeding after injury.

In addition to its role in thrombopoiesis, TPO has been shown to have potential effects on other cell types, including hematopoietic stem cells and certain immune cells. However, its primary function remains the regulation of platelet production.

Secondary hyperparathyroidism is a condition characterized by an overproduction of parathyroid hormone (PTH) from the parathyroid glands due to hypocalcemia (low levels of calcium in the blood). This condition is usually a result of chronic kidney disease, where the kidneys fail to convert vitamin D into its active form, leading to decreased absorption of calcium in the intestines. The body responds by increasing PTH production to maintain normal calcium levels, but over time, this results in high PTH levels and associated complications such as bone disease, kidney stones, and cardiovascular calcification.

The parathyroid glands are four small endocrine glands located in the neck, usually near or behind the thyroid gland. They secrete parathyroid hormone (PTH), which plays a critical role in regulating calcium and phosphate levels in the blood and bones. PTH helps maintain the balance of these minerals by increasing the absorption of calcium from food in the intestines, promoting reabsorption of calcium in the kidneys, and stimulating the release of calcium from bones when needed. Additionally, PTH decreases the excretion of calcium through urine and reduces phosphate reabsorption in the kidneys, leading to increased phosphate excretion. Disorders of the parathyroid glands can result in conditions such as hyperparathyroidism (overactive glands) or hypoparathyroidism (underactive glands), which can have significant impacts on calcium and phosphate homeostasis and overall health.

Hyperparathyroidism is a condition in which the parathyroid glands produce excessive amounts of parathyroid hormone (PTH). There are four small parathyroid glands located in the neck, near or within the thyroid gland. They release PTH into the bloodstream to help regulate the levels of calcium and phosphorus in the body.

In hyperparathyroidism, overproduction of PTH can lead to an imbalance in these minerals, causing high blood calcium levels (hypercalcemia) and low phosphate levels (hypophosphatemia). This can result in various symptoms such as fatigue, weakness, bone pain, kidney stones, and cognitive issues.

There are two types of hyperparathyroidism: primary and secondary. Primary hyperparathyroidism occurs when there is a problem with one or more of the parathyroid glands, causing them to become overactive and produce too much PTH. Secondary hyperparathyroidism develops as a response to low calcium levels in the body due to conditions like vitamin D deficiency, chronic kidney disease, or malabsorption syndromes.

Treatment for hyperparathyroidism depends on the underlying cause and severity of symptoms. In primary hyperparathyroidism, surgery to remove the overactive parathyroid gland(s) is often recommended. For secondary hyperparathyroidism, treating the underlying condition and managing calcium levels with medications or dietary changes may be sufficient.

Parathyroid hormone (PTH) is a polypeptide hormone that plays a crucial role in the regulation of calcium and phosphate levels in the body. It is produced and secreted by the parathyroid glands, which are four small endocrine glands located on the back surface of the thyroid gland.

The primary function of PTH is to maintain normal calcium levels in the blood by increasing calcium absorption from the gut, mobilizing calcium from bones, and decreasing calcium excretion by the kidneys. PTH also increases phosphate excretion by the kidneys, which helps to lower serum phosphate levels.

In addition to its role in calcium and phosphate homeostasis, PTH has been shown to have anabolic effects on bone tissue, stimulating bone formation and preventing bone loss. However, chronic elevations in PTH levels can lead to excessive bone resorption and osteoporosis.

Overall, Parathyroid Hormone is a critical hormone that helps maintain mineral homeostasis and supports healthy bone metabolism.

Primary hyperparathyroidism is a medical condition characterized by excessive secretion of parathyroid hormone (PTH) from one or more of the parathyroid glands in the neck. These glands are normally responsible for regulating calcium levels in the body by releasing PTH, which helps to maintain an appropriate balance of calcium and phosphate in the bloodstream.

In primary hyperparathyroidism, the parathyroid gland(s) become overactive and produce too much PTH, leading to elevated calcium levels (hypercalcemia) in the blood. This can result in a variety of symptoms, such as fatigue, weakness, bone pain, kidney stones, and cognitive impairment, although some individuals may not experience any symptoms at all.

The most common cause of primary hyperparathyroidism is a benign tumor called an adenoma that develops in one or more of the parathyroid glands. In rare cases, primary hyperparathyroidism can be caused by cancer of the parathyroid gland(s) or by enlargement of all four glands (four-gland hyperplasia). Treatment typically involves surgical removal of the affected parathyroid gland(s), which is usually curative.

Parathyroidectomy is a surgical procedure for the removal of one or more of the parathyroid glands. These glands are located in the neck and are responsible for producing parathyroid hormone (PTH), which helps regulate the levels of calcium and phosphorus in the body.

Parathyroidectomy is typically performed to treat conditions such as hyperparathyroidism, where one or more of the parathyroid glands become overactive and produce too much PTH. This can lead to high levels of calcium in the blood, which can cause symptoms such as weakness, fatigue, bone pain, kidney stones, and mental confusion.

There are different types of parathyroidectomy procedures, including:

* Partial parathyroidectomy: removal of one or more, but not all, of the parathyroid glands.
* Total parathyroidectomy: removal of all four parathyroid glands.
* Subtotal parathyroidectomy: removal of three and a half of the four parathyroid glands, leaving a small portion of one gland to prevent hypoparathyroidism (a condition where the body produces too little PTH).

The choice of procedure depends on the underlying condition and its severity. After the surgery, patients may need to have their calcium levels monitored and may require calcium and vitamin D supplements to maintain normal calcium levels in the blood.

Parathyroid neoplasms refer to abnormal growths in the parathyroid glands, which are small endocrine glands located in the neck, near or within the thyroid gland. These neoplasms can be benign (non-cancerous) or malignant (cancerous).

Benign parathyroid neoplasms are typically called parathyroid adenomas and are the most common type of parathyroid disorder. They result in overproduction of parathyroid hormone (PTH), leading to a condition known as primary hyperparathyroidism. Symptoms may include kidney stones, osteoporosis, fatigue, depression, and abdominal pain.

Malignant parathyroid neoplasms are called parathyroid carcinomas. They are rare but more aggressive than adenomas, with a higher risk of recurrence and metastasis. Symptoms are similar to those of benign neoplasms but may also include hoarseness, difficulty swallowing, and enlarged lymph nodes in the neck.

It is important to note that parathyroid neoplasms can only be definitively diagnosed through biopsy or surgical removal and subsequent histopathological examination.

It can manifest in localized or generalized osteosclerosis. Localized osteosclerosis can be caused by Legg-Calvé-Perthes ... Osteosclerosis is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density. It may ... Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary. Osteogenic bone ... Fiore CE, Riccobene S, Mangiafico R, Santoro F, Pennisi P (2005). "Hepatitis C-associated osteosclerosis (HCAO): report of a ...
... , also known as enostosis or dense bone island, is a condition which may be found around the roots of ... These features help differentiate idiopathic osteosclerosis from similar entities such as condensing osteitis, cemento-osseous ... Condensing osteitis may resemble idiopathic osteosclerosis, however, associated teeth are always nonvital in condensing ...
CHEK2 Osteosclerosis; 144750; LRP5 Otofaciocervical syndrome; 166780; EYA1 Otopalatodigital syndrome, type I; 311300; FLNA ...
Idiopathic osteosclerosis • Implantology • Implant-supported bridge • Impression • Incisor • Inferior alveolar nerve • ...
Osteosclerosis, an elevation in bone density, is normally detected on an X-ray as an area of whiteness and is where the bone ... "Medcyclopaedia - Osteosclerosis". Retrieved 2007-12-23. Marks, Dawn B.; Swanson, Todd; Sandra I Kim; Marc Glucksman (2007). ...
1- Idiopathic osteosclerosis. 2- cementoblastoma. NOTE: An abnormal result with pulp testing strongly suggests condensing ... which is termed osteosclerosis or bone scar. Silva, Brunno Santos Freitas; Bueno, Mike Reis; Yamamoto-Silva, Fernanda P.; Gomez ... osteitis and tends to rule out osteosclerosis and cementoblastoma. The process is usually asymptomatic and benign, in most ...
Osteosclerosis Pachyosteosclerosis Domning, D. P.; Debuffrenil, V. (1991). "Hydrostasis in the Sirenia - Quantitative Data and ... It often occurs together with bone densification (osteosclerosis), reducing inner cavities. This joint occurrence is called ...
CT shows focal areas of osteosclerosis. Brown tumors in the pelvis and a hip fracture. Subchondral resorption in the sacroiliac ...
"Osteosclerosis - Stanescu type (Concept Id: C0432263) - MedGen - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-07-05. " ... "Osteosclerosis-developmental delay-craniosynostosis syndrome (Concept Id: C4302818)". www.ncbi.nlm.nih.gov. Retrieved 2023-07- ...
"Autosomal dominant osteosclerosis type Stanescu: the third family". American Journal of Medical Genetics. 57 (4): 605-609. doi: ...
It is not affected by local osteosclerosis and proliferation. Therefore, it can be used as a means of large-area bone mineral ...
The skeleton of sirenians displays both pachyostosis and osteosclerosis... Takahashi, S.; Domning, D. P.; Saito, T. (1986). " ...
Pachyostosis Osteosclerosis Domning, D. P. and V. Debuffrenil (1991). Hydrostasis in the Sirenia - Quantitative Data and ... Pachyosteosclerosis is a combination of thickening (pachyostosis) and densification (osteosclerosis) of bones. It makes bones ...
It is one of the hereditary causes of osteosclerosis. It is considered to be the prototype of osteosclerosing dysplasias. The ... The differential diagnosis of osteopetrosis includes other disorders that produce osteosclerosis. They constitute a wide array ... Besides, the differential diagnosis includes acquired conditions that induce osteosclerosis such as osteosclerotic metastasis ... 2011). "Sclerosing bone dysplasias: Review and differentiation from other causes of osteosclerosis". RadioGraphics. 31 (7): ...
Lehman RAW, Stears JC, Wesenberg RL, Nusbaum ED (1977) Familial osteosclerosis with abnormalities of the nervous system and ... "Familial osteosclerosis with abnormalities of the nervous system and meninges". The Journal of Pediatrics. 90 (1): 49-54. doi: ...
The bones show osteosclerosis, increasing their density to reduce buoyancy. The sea otter presents an insight into the ...
... osteosclerosis). Additionally, individuals also have an abnormally large head circumference (macrocephaly) with a prominent ...
Their bones show osteosclerosis, increasing their density to reduce buoyancy. This otter differs from the North American river ...
Review and Differentiation from Other Causes of Osteosclerosis". RadioGraphics. 31 (7): 1865-1882. doi:10.1148/rg.317115093. ...
Review and Differentiation from Other Causes of Osteosclerosis". RadioGraphics. 31 (7): 1865-1882. doi:10.1148/rg.317115093. ...
2011). "Sclerosing bone dysplasias: Review and differentiation from other causes of osteosclerosis". RadioGraphics. 31:7, 1865- ... appearance in the pelvis and long bones of extremities where areas of osteosclerosis intermingle with areas of relatively ... diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. They are ...
It also shows a degree of osteosclerosis, a condition shared with Polarornis. This different degrees of osteosclerosis could be ...
That is, unlike many other aquatic mammals, the ribs did not exhibit osteosclerosis. They did exhibit pachyostosis, and were ...
Osteosclerosis occurs at a margin where new bone is placed over dead trabeculae. When the trabeculae experience stress leading ...
... 's leg bones had osteosclerosis (high bone density), allowing for better buoyancy control. Multiple functions have ...
It is also associated with a benign inner ear dysplasia known as osteosclerosis. The disorder is progressive, with the ultimate ...
The four main presentations include spondylodiscitis, osteosclerosis, paravertebral ossifications, and sacroiliac joint ...
Bone abnormalities can be seen on radiological imaging (often increased density or osteosclerosis) or biopsy. There are two ...
In PMF, the bony aspects of bone marrow are remodeled in a process called osteosclerosis; in addition, fibroblast secrete ... "osteosclerosis" in 1907. It was characterised as a myeloproliferative condition in 1951 by William Dameshek. The disease was ...
... and osteosclerosis. Journal of medical genetics,26(12), 786-788. Simpson, M. A., Hsu, R., Keir, L. S., Hao, J., Sivapalan, G., ... osteosclerosis, a cleft palate, gum hyperplasia, a hypoplastic nose, and eye proptosis. It is considered to be a lethal disease ... and osteosclerosis". J. Med. Genet. 26 (12): 786-788. doi:10.1136/jmg.26.12.786. PMC 1015765. PMID 2614802. FAMILY WITH ...
It can manifest in localized or generalized osteosclerosis. Localized osteosclerosis can be caused by Legg-Calvé-Perthes ... Osteosclerosis is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density. It may ... Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary. Osteogenic bone ... Fiore CE, Riccobene S, Mangiafico R, Santoro F, Pennisi P (2005). "Hepatitis C-associated osteosclerosis (HCAO): report of a ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
The ultimate reference tool for primary care medicine.
Osteosclerosis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional ... Osteosclerosis is a type of osteopetrosis Overview of Osteopetroses Osteopetroses are familial disorders characterized by ... It is less severe than osteopetrosis with precocious manifestations Osteopetrosis with precocious manifestations Osteosclerosis ...
Osteosclerosis refers to an abnormal hardening of bone tissue ... Learn and reinforce your understanding of Osteosclerosis. Check ... Osteosclerosis refers to an abnormal hardening of bone tissue, which is due to decreased bone resorption, and increased bone ...
Osteosclerosis secondary to metastatic oligodendroglioma. / Maloney, Patrick Ryan; Yamaki, Vitor Nagai; Kumar, Ravi et al. In: ... Osteosclerosis secondary to metastatic oligodendroglioma. Rare Tumors. 2017 Mar 31;9(1):23-25. 6837. doi: 10.4081/rt.2017.6837 ... Osteosclerosis secondary to metastatic oligodendroglioma. Patrick Ryan Maloney, Vitor Nagai Yamaki, Ravi Kumar, Derek Johnson, ... Osteosclerosis secondary to metastatic oligodendroglioma. In: Rare Tumors. 2017 ; Vol. 9, No. 1. pp. 23-25. ...
Idiopathic osteosclerosis was observed as a bone radiopacity increase located inside the bone, measuring 3 mm or more, with no ... Four cases of osteosclerosis were observed in EG and 4 cases CG (7.41%). No significant correlation was found between ... Idiopathic osteosclerosis is a bone tissue structural change whose etiologic factor remains unknown. It is also known as ... Although idiopathic osteosclerosis is not a rare entity, little importance has been given by orthodontists to its occurrence, ...
The Osteosclerosis is also called as the marble bone disease. The Osteosclerosis is a type of disease that is chronic in nature ... A patient having Osteosclerosis can feel little dizzy all the time.. Osteosclerosis causes As far as the causes are concerned, ... Osteosclerosis Symptoms The problem of Osteosclerosis can be identified with the help of symptoms. These symptoms can make the ... The Localized Osteosclerosis is a problem that can be related to family issues like the heredity. In Osteosclerosis there is a ...
Resolution of osteosclerosis after alloHCT in systemic mastocytosis, Blood, Volume 127, Issue 14, 7 April 2016, Pages ... Resolution of osteosclerosis after alloHCT in systemic mastocytosis Celalettin Ustun, Celalettin Ustun ... Diffuse or focal osteosclerosis, common in systemic mastocytosis, was seen in this patient (panels A-B; hematoxylin and eosin [ ... Diffuse or focal osteosclerosis, common in systemic mastocytosis, was seen in this patient (panels A-B; hematoxylin and eosin [ ...
Worth Type Autosomal Dominant Osteosclerosis): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and ... Prognosis - Osteosclerosis autosomal dominant Worth type Not supplied. Treatment - Osteosclerosis autosomal dominant Worth type ... How can Autosomal Dominant Osteosclerosis, Worth type be Prevented? Currently, Autosomal Dominant Osteosclerosis, Worth type ... Resources - Osteosclerosis autosomal dominant Worth type Not supplied. [checkorphan.org] Further studies of the long term ...
Diaphyseal osteosclerosis. *Engelmann disease. *PDD. *Progressive diaphyseal dysplasia. Additional Information & Resources. ...
Osteosclerosis / pathology* ...
Idiopathic osteosclerosis of the jaws on panoramic radiograpic analysis in Indonesian Sub-Population * Irfan Sugianto , ... Objective: To determine prevalence of Idiopathic osteosclerosis (IO) by radiographic evaluation and to investigate the ... Idiopathic Osteosclerosis can defined as developmental variation that can occur in any age range, no predilection of sex. The ... Idiopathic osteosclerosis of the jaws on panoramic radiograpic analysis in Indonesian Sub-Population . Journal of ...
Osteosclerosis / diagnosis * Osteosclerosis / diagnostic imaging * Pain / diagnosis * Pain / diagnostic imaging * Radiography * ...
Plural Publishing Launches New Title: Osteosclerosis: Diagnosis, Evaluation, Pathology, Surgical Techniques, and Outcomes. ...
Plural Publishing Launches New Title: Osteosclerosis: Diagnosis, Evaluation, Pathology, Surgical Techniques, and Outcomes. ...
Note the osteosclerosis and a brown tumor in the region of the intertrochanteric line of the left femur. ... Osteosclerosis may affect the epiphyses, metaphyses, pelvis, and ribs. Frequently, a classic rugger-jersey spine is observed; ...
... osteosclerosis, plantar fasciitis, rheumatoid arthritis, tendon rupture. ...
Combined focal osteolytic lesions with nearby osteosclerosis. *Bone deformity or enlargement. *Cortical thickening ...
... osteosclerosis, plantar fasciitis, rheumatoid arthritis, tendon rupture.. Nervous system-Frequent: trismus, vertigo; Infrequent ...
Bone changes observed in human skeletal fluorosis are structural and functional, with a combination of osteosclerosis, ...
"At high dosages (1 mg F/day) osteosclerosis is seen within a year; later, resorption cavities occur. At more moderate dosages ( ... 0.3 mg F/day) no osteosclerosis is seen but resorption cavities sometimes occur, however… The resorption cavities which occur ...
The characteristic radiographical finding is bilateral, symmetric osteosclerosis of the long bones. Osteolytic lesions are ...
Background Osteopetrosis is a rare, inherited, bone disorder, characterized by osteosclerosis, obliteration of the medullary ...
Caliskan MK, Turkun M, Oztop F. Histological evaluation of a tooth with hyperplastic pulpitis and periapical osteosclerosis. ...
It is usually identifiable with plain radiograph with osteosclerosis and "bone-within-bone" appearance on skeletal survey. ...
Advanced MF is not only typified by BMF, but also by osteosclerosis with an increase and thickening of the bone trabeculae. ... Quantification of fibrosis and osteosclerosis in myeloproliferative neoplasms: a computer-assisted image study. Leuk Res. 2010 ... Additionally, osteosclerosis was seen only in mice engrafted with wild-type cells.15 ... None of the patients had improvement in BMF or osteosclerosis. Additionally, there were no significant clinical benefits seen ...
The major radiological finding was osteosclerosis in 70% of patients. Mean serum concentration of aluminum was 25.4 ± 17.7 µg/L ...
  • The aim of the present study was to investigate whether an increased prevalence of idiopathic osteosclerosis exists in patients with palatally impacted maxillary canines. (bvsalud.org)
  • Objective: To determine prevalence of Idiopathic osteosclerosis (IO) by radiographic evaluation and to investigate the relationship between the finding in relation with age, gender and location in Indonesia Sub-Population. (jdmfs.org)
  • Differential diagnosis and treatment of autosomal dominant osteosclerosis of the mandible. (bvsalud.org)
  • Findings of spinal involvement on conventional radiographic imaging have been reported to include vertebral body osteosclerosis, paravertebral ligament ossification, hyperostosis, and discovertebral junction lesions. (ajnr.org)
  • Other tables give estimated total fluoride emissions from major industrial sources in the United States in 1968, presence of osteosclerosis, radiographic changes and years of exposure, and comparison of fluoride effects in man and animals. (cdc.gov)
  • Idiopathic osteosclerosis is an asymptomatic, non-expansive and localized increase of bone radiopacity caused by an increase in the width of the bone trabeculae at the expense of medullary space. (bvsalud.org)
  • Background Osteopetrosis is a rare, inherited, bone disorder, characterized by osteosclerosis, obliteration of the medullary cavity and calcified cartilage. (medscape.com)
  • Rare bone diseases such as osteopetrosis and hereditary osteoscleroses are also caused by mutations in genes that affect bone cell function. (biomedcentral.com)
  • Osteosclerosis is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density. (wikipedia.org)
  • Osteosclerosis is an increased bone density as defined radiologically. (gpnotebook.com)
  • In Osteosclerosis, the patients have the high bone density. (healthcaretip.com)
  • This paper reviews a case of metastatic 1p/19q codeleted oligodendrioglioma causing diffuse osteosclerosis and pain. (elsevierpure.com)
  • Osteosclerosis is the name of disorder that is primarily concerned with the ear bones. (healthcaretip.com)
  • In those animal groups, osteosclerosis often occurs together with bone thickening (pachyostosis). (wikipedia.org)
  • Osteosclerosis occurs because of mutations in genes that increase osteoblast activity, including SOST, transforming growth factor beta and LRP5. (biomedcentral.com)
  • The patient achieved a partial reduction in MC burden at 6 months posttransplantation (serum tryptase decreased from 1660 ng/mL to 843 ng/mL), but osteosclerosis persisted. (ashpublications.org)
  • Osteosclerosis refers to an abnormal hardening of bone tissue , which is due to decreased bone resorption, and increased bone formation. (osmosis.org)
  • The abnormal hardening of the bones and the bones density is said to be the Osteosclerosis. (healthcaretip.com)
  • The problem of Osteosclerosis can be identified with the help of symptoms. (healthcaretip.com)
  • Bone changes observed in human skeletal fluorosis are structural and functional, with a combination of osteosclerosis, osteomalacia, osteoporosis and exostosis formation, and secondary hyperparathyroidism in a proportion of patients. (poisonfluoride.com)
  • Localized osteosclerosis can be caused by Legg-Calvé-Perthes disease, sickle-cell disease and osteoarthritis among others. (wikipedia.org)
  • The Osteosclerosis is also called as the marble bone disease . (healthcaretip.com)
  • The Osteosclerosis is a type of disease that is chronic in nature and it can affect the structure of the bones in the inner ear. (healthcaretip.com)
  • As Osteosclerosis is a problem that is related to bones, the patient suffering from the Osteosclerosis can have hearing issues aswell. (healthcaretip.com)
  • To investigate the association between palatally impacted maxillary canines (PIC) and idiopathic osteosclerosis. (bvsalud.org)
  • In some rare cases, the Osteosclerosis can cause the bone of the ear to have a fracture as well. (healthcaretip.com)
  • Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system" (PDF). (wikipedia.org)
  • Four patients from each group had idiopathic osteosclerosis (7.41%), a rate that falls in the prevalence range reported in the literature. (bvsalud.org)
  • citation needed] In the animal kingdom, there also exists a non-pathological form of osteosclerosis, resulting in unusually solid bone structure with little to no marrow. (wikipedia.org)
  • In Osteosclerosis there is a sponge-like structure developed inside the bone of the middle ear. (healthcaretip.com)
  • Early on there is osteolysis and, later, affected areas of bone demonstrate osteosclerosis and hyperostosis. (logicalimages.com)
  • Findings of spinal involvement on conventional radiographic imaging have been reported to include vertebral body osteosclerosis, paravertebral ligament ossification, hyperostosis, and discovertebral junction lesions. (ajnr.org)
  • citation needed] In the animal kingdom, there also exists a non-pathological form of osteosclerosis, resulting in unusually solid bone structure with little to no marrow. (wikipedia.org)
  • Appearance of bone tissue shown in the picture is determined by the current form of osteosclerosis. (kakprosto.ru)
  • subchondral osteosclerosis and cystic changes. (czkealor.com)
  • Take timely prevention and treatment arise during the course of osteosclerosis complications (anemia changes in blood composition, various skeletal deformities, etc. (kakprosto.ru)
  • Osteosclerosis in the skeletal fluorosis patients was very serious. (nih.gov)
  • The tremendous bone mass of Perucetus is caused by two types of modifications of the skeleton, the addition of extra bone on the outer surface of the skeletal elements (giving them a bloated appearance, called pachyostosis) and the filling of inner cavities with compact bone (called osteosclerosis), adding even more weight to the skeleton. (naturalsciences.be)
  • Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system" (PDF). (wikipedia.org)
  • The teeth are mottled, and there is osteosclerosis and osteomalacia. (espimetals.com)
  • Bony abnormalities, including osteosclerosis, are reported. (medscape.com)
  • Our asymptomatic patient showed radiographic changes consistent with osteopoikilosis, osteopathia striata, and melorheostosis and had widespread osteosclerosis of the axial skeleton. (wustl.edu)
  • Adam Savage suffers from osteosclerosis which is a genetic disorder. (starzuncut.com)
  • Osteosclerosis is a pathological compaction of bone tissue, formed as a result of violations of blood flow in them, as well as chronic infections or the presence of tumor growths. (kakprosto.ru)
  • The daughter had generalized osteosclerosis, flattening of the angles of the mandibles, high-arched palate, mandibular and facial bone hypoplasia, a large sella turcica, and spacious foramen magnum, platybasia, basilar impression, widened spinal cord with enlarged intervertebral foramina, and scalloping of the posterior surfaces of the vertebral bodies. (nih.gov)